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Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children
- Publication Year :
- 2019
-
Abstract
- PubMedID: 31005273 Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6–17 years with baseline estimated glomerular filtration rate (eGFR) of 10–60 ml/min/1.73 m2. uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for
- Subjects :
- Male
0301 basic medicine
Chronic kidney failure
Physiology
Protein function
Medizin
030232 urology & nephrology
Comorbidity
Urine
urologic and male genital diseases
Gastroenterology
0302 clinical medicine
Pathology
Urology & nephrology
Estimated glomerular filtration rate
Disease course
pediatric CKD
Child
Priority journal
Kidney
female genital diseases and pregnancy complications
CKD progression
chronic kidney disease
epidermal growth factor
3. Good health
Risk-factors
Proteinuria
medicine.anatomical_structure
Nephrology
Systolic blood pressure
Glomerulus filtration rate
Biomarker (medicine)
Female
Glomerular filtration rate
Cohort analysis
Age factors
Human
medicine.medical_specialty
Adolescent
Urinary system
Excretion
Predictive value
Renal function
Follow-up studies
Major clinical study
Urinalysis
Pathophysiology
Article
Roles
03 medical and health sciences
Age
Internal medicine
Post-hoc analysis
medicine
Humans
Predictive value of tests
Post hoc analysis
Renal insufficiency, chronic
Prospective study
Disease exacerbation
Egf
Disease progression
Renal replacement therapy
business.industry
Follow up
medicine.disease
Glomerulopathy
Chronic Kidney Failure
Kidney Diseases
Young-adults
Biological marker
030104 developmental biology
Risk factors
Risk factor
Prediction
business
Prospective studies
Controlled study
Biomarkers
Kidney disease
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....68140d31ec5ecf1a2a98e8a6421a89ec