86 results on '"Ocal, R"'
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2. Cross-sectional, hospital-based analysis of headache types using ICHD-3 criteria in the Middle East, Asia, and Africa: the Head-MENAA study
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Yifru, Y M, Genc, H, Baykan, B, Bolay, HAYRUNNİSA BOLAY, Sanli, Z S, Azizova, I, Bayır, Brh, Tepe, N, Okluoglu, T, Nasergivehchi, S, Demir, T G, Velioglu, S K, Badr, M Y, Vuralli, D, Jafari, E, Gumanovna, V K, Kabay, S C, Nowar, A G, Moustafa, R R, Polat, B, Ermis, A, Khanmammadov, E, Yolcu, O, Kul, B, Kirbasoglu, O, Sakadi, F, Ulutas, S, Akturk, T, Ketema, M T, Lala, S, Cedric, Apsa, Uluduz, D, Unal-Cevik, I, Kissani, N, Luvsannorov, O, Togha, M, Ozdemir, A A, Ozge, A, Cakan, M, Ak, A K, Celik, F, Orun, M O, Seker, D, Kucuk, A, Ozkan, S, Kiraz, M, Alemayehu, B, Melka, D, Orhan, E K, Sirin, T C, Ocal, R, Ekizoglu, E, Hakyemez, H A, Yener, M O, Serim, V A, Cinar, N, Unal, E D, Domac, F M, Ates, M F, Turkoglu, B G, Gursoy, G, Cekic, S, Aslan, S K, Agircan, D, Oktar, A C, Demirel, E A, Gelener, P, Kizek, O, Ibrahim, Eaa, Evlice, A, and Gorken, G
- Subjects
Anesthesiology and Pain Medicine ,Neurology (clinical) ,General Medicine - Abstract
Background Headaches are frequent neurological disorders that are yet to be unveiled and treated comprehensively worldwide. Bearing in mind that the distribution of headache subtypes in neurology clinics (NC) is essential for planning appropriate diagnostic and therapeutic approaches, the primary goals of this multi-centric study are to carry out inter-regional comparisons by using current diagnostic criteria with evaluations of neurologists to delineate headache burden. Methods A cross-sectional study between April 1 and May 16, 2022 was conducted with the participation of 13 countries from the Middle East, Asia, and Africa. Patients were included in the study on a specific day each week during five consecutive weeks. All volunteers over the age of 18 and whose primary cause for admission was headache were examined. The patients admitted to NC or referred from emergency services/other services were evaluated by neurologists by means of the International Classification of Headache Disorders (ICHD-3) criteria. Results Among the 13,794 patients encountered in NC, headache was the primary complaint in 30.04%. The headache patients’ mean age was 42.85 ± 14.89 (18–95 years), and 74.3% were female. According to the ICHD-3 criteria, 86.7% of the main group had primary headache disorders, 33.5% had secondary headaches, 4% had painful cranial neuropathies along with other facial and headaches, and 5.2% had headaches included in the appendix part showing some overlapping conditions. While the most common primary headache was migraine without aura (36.8%), the most common secondary headache was medication-overuse headache (MOH) (9.8%). Headaches attributed to COVID-19, its secondary complications, or vaccines continue to occur at rates of 1.2%-3.5% in current neurology practice. Pain severity was significantly lower in Ivory Coast and Sudan than in Türkiye, Turkish Republic of Northern Cyprus, Iran, Egypt, Senegal, Tatarstan, and Azerbaijan (p Conclusions The study showed that migraine is still the most common motive for admissions to NC in different regions. Furthermore, MOH, an avoidable disorder, is the most common secondary headache type and appears to be a significant problem in all regions. Remarkably, pain perception differs between regions, and pain intensity is lower in Africa than in other regions.
- Published
- 2023
3. The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database
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Vincent, J, Ferguson, A, Pickkers, P, Jakob, S, Jaschinski, U, Almekhlafi, G, Leone, M, Mokhtari, M, Fontes, L, Bauer, P, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Lee, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Nishida, O, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Marshall, J, Herridge, M, Fernandez-Medero, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Nanchal, R, Wunderink, R, Jimenez, E, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Hawkins, D, Kilminster, M, Sturgess, D, Ziegenfuss, M, O' Connor, S, Lipman, J, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, D'Agostino Dias, M, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Villalba Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Juan Francisco, L, Namendys-Silva, S, Moya, R, Hernandez, M, Rodriguez Cadena, D, Islas, I, Ballesteros Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Mareque Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, G, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Spapen, H, Van Collie, O, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Lepoivre, T, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Martin-Loeches, I, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, Martos, C, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Haller, A, Matthew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Norton, A, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Alexander, P, Henderson, S, Hargreaves, C, Black, H, Gowda, K, Vincent J. -L., Ferguson A., Pickkers P., Jakob S. M., Jaschinski U., Almekhlafi G. A., Leone M., Mokhtari M., Fontes L. E., Bauer P. R., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M. N., Nica A., Stoica R., Tomescu D. R., Constantinescu D. L., Valcoreanu Zbaganu G. M., Slavcovici A., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X. Z., Zhao X., Li C. H., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T. H., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Li C., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W. L., Sin K. K. C., Lee K. L., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T. T., Hata N., Kobe Y., Nishida O., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. A. N., Tai L. L., Tony B., Bigornia R. R., Palo J. E., Chatterjee S., Tan B. H., Kong A., Goh S., Lee C. -C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Nowruzinia S., Lotfi A. H., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A. Y., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H. K., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Marshall J. C., Herridge M., Fernandez-Medero R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R. G., Jimenez E., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Hawkins D. J., Kilminster M., Sturgess D., Ziegenfuss M., O' Connor S., Lipman J., Campbell L., McAllister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M. M., D'Agostino Dias M., Lunardi M. C., Youssef N. C., Lobo S., Silva R., Sales J. A., Melo L. M. C., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A. P., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Filho R. C., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro Castro L. F., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Villalba Gaviria M. C., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Juan Francisco L. L., Namendys-Silva S. A., Moya R. G., Hernandez M., Rodriguez Cadena D. M., Islas I. L., Ballesteros Zarzavilla C. M., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Mareque Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal G., Lahkar B., Mandal A. K., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe K., Patel M., Bhavsar A., Samaddar D. P., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K. -H., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Gadisseux P., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J. J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Spapen H., Van Collie O., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V. -P., Saarinen K., Durocher A., Moulront S., Lepape A., Losser M. -R., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Lefrant J. -Y., Beilouny B., Forceville X., Misset B., Jacobs F., Floccard B., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Lepoivre T., Moussa M. D., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C. -J., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R. A., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S. O., Barry J., O'Leary R. A., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M. F., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J. J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Martin-Loeches I., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M. A., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Perez Granda M. J., Moreno S., Llubia C., Martos C. D. L. F., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Quindos B., Quintano A., Tebar M. T., Cardinal P., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J. A., Pedregosa A. 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B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Norton A., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Alexander P., Henderson S., Hargreaves C., Black H., Gowda K, Citerio G, Vincent, J, Ferguson, A, Pickkers, P, Jakob, S, Jaschinski, U, Almekhlafi, G, Leone, M, Mokhtari, M, Fontes, L, Bauer, P, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, 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Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Alexander, P, Henderson, S, Hargreaves, C, Black, H, Gowda, K, Vincent J. -L., Ferguson A., Pickkers P., Jakob S. M., Jaschinski U., Almekhlafi G. A., Leone M., Mokhtari M., Fontes L. E., Bauer P. R., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M. N., Nica A., Stoica R., Tomescu D. R., Constantinescu D. L., Valcoreanu Zbaganu G. M., Slavcovici A., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X. Z., Zhao X., Li C. H., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T. H., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Li C., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W. L., Sin K. K. C., Lee K. L., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T. T., Hata N., Kobe Y., Nishida O., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. A. N., Tai L. L., Tony B., Bigornia R. R., Palo J. E., Chatterjee S., Tan B. H., Kong A., Goh S., Lee C. -C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Nowruzinia S., Lotfi A. H., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A. Y., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H. K., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Marshall J. C., Herridge M., Fernandez-Medero R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R. 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K., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe K., Patel M., Bhavsar A., Samaddar D. P., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K. -H., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Gadisseux P., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J. J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Spapen H., Van Collie O., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V. -P., Saarinen K., Durocher A., Moulront S., Lepape A., Losser M. -R., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Lefrant J. -Y., Beilouny B., Forceville X., Misset B., Jacobs F., Floccard B., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Lepoivre T., Moussa M. D., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C. -J., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R. A., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S. O., Barry J., O'Leary R. A., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M. F., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J. J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Martin-Loeches I., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M. A., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Perez Granda M. J., Moreno S., Llubia C., Martos C. D. L. F., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Quindos B., Quintano A., Tebar M. T., Cardinal P., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J. A., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Matthew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Norton A., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Alexander P., Henderson S., Hargreaves C., Black H., Gowda K, and Citerio G
- Abstract
Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.
- Published
- 2020
4. Oxidative stress status and plasma trace elements in patients with asthma or allergic rhinitis
- Author
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Sagdic, A., Sener, O., Bulucu, F., Karadurmus, N., Özel, H.E., Yamanel, L., Tasci, C., Naharci, I., Ocal, R., and Aydin, A.
- Published
- 2011
- Full Text
- View/download PDF
5. Oxidative stress status in patients with chronic idiopathic urticaria
- Author
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Sagdic, A., Sener, O., Bulucu, F., Karadurmus, N., Yamanel, L., Tasci, C., Naharci, I., Ocal, R., and Aydin, A.
- Published
- 2011
- Full Text
- View/download PDF
6. The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database
- Author
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Vincent J. -L., Ferguson A., Pickkers P., Jakob S. M., Jaschinski U., Almekhlafi G. A., Leone M., Mokhtari M., Fontes L. E., Bauer P. R., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M. N., Nica A., Stoica R., Tomescu D. R., Constantinescu D. L., Valcoreanu Zbaganu G. M., Slavcovici A., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X. Z., Zhao X., Li C. H., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T. H., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Li C., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W. L., Sin K. K. C., Lee K. L., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T. T., Hata N., Kobe Y., Nishida O., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. A. N., Tai L. L., Tony B., Bigornia R. R., Palo J. E., Chatterjee S., Tan B. H., Kong A., Goh S., Lee C. -C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Nowruzinia S., Lotfi A. H., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A. Y., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H. K., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Marshall J. C., Herridge M., Fernandez-Medero R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R. G., Jimenez E., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Hawkins D. J., Kilminster M., Sturgess D., Ziegenfuss M., O' Connor S., Lipman J., Campbell L., McAllister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M. M., D'Agostino Dias M., Lunardi M. C., Youssef N. C., Lobo S., Silva R., Sales J. A., Melo L. M. C., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A. P., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Filho R. C., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro Castro L. F., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Villalba Gaviria M. C., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Juan Francisco L. L., Namendys-Silva S. A., Moya R. G., Hernandez M., Rodriguez Cadena D. M., Islas I. L., Ballesteros Zarzavilla C. M., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Mareque Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal G., Lahkar B., Mandal A. K., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe K., Patel M., Bhavsar A., Samaddar D. P., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K. -H., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Gadisseux P., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J. J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Spapen H., Van Collie O., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V. -P., Saarinen K., Durocher A., Moulront S., Lepape A., Losser M. -R., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Lefrant J. -Y., Beilouny B., Forceville X., Misset B., Jacobs F., Floccard B., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Lepoivre T., Moussa M. D., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C. -J., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R. A., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S. O., Barry J., O'Leary R. A., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M. F., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J. J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Martin-Loeches I., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M. A., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Perez Granda M. J., Moreno S., Llubia C., Martos C. D. L. F., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Quindos B., Quintano A., Tebar M. T., Cardinal P., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J. A., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Matthew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Norton A., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Alexander P., Henderson S., Hargreaves C., Black H., Gowda K, Citerio G, Université libre de Bruxelles (ULB), Belfast City Hospital, Department Intensive Care Medicine, Center of Infectious Diseases, Radboudumc, Nijmegen, The Netherlands., University of Bern [Bern, Switzerland] (University Hospital Bern ), Universität Augsburg [Augsburg], Prince Sultan university (saudi Arabia), Riyadh, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Assistance Publique - Hôpitaux de Marseille (APHM), Mayo Clinic, Jena University Hospital [Jena], Supporting clinical sciences, Intensive Care, Internal Medicine Specializations, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, UCL - (SLuc) Service de soins intensifs, Vincent, J. -L., Ferguson, A., Pickkers, P., Jakob, S. M., Jaschinski, U., Almekhlafi, G. A., Leone, M., Mokhtari, M., Fontes, L. E., Bauer, P. R., Sakr, Y., Tomas, E., Bibonge, E. A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M. N., Nica, A., Stoica, R., Tomescu, D. R., Constantinescu, D. L., Valcoreanu Zbaganu, G. M., Slavcovici, A., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X. Z., Zhao, X., Li, C. H., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T. H., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Li, C., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W. L., Sin, K. K. C., Lee, K. L., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T. T., Hata, N., Kobe, Y., Nishida, O., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. A. N., Tai, L. L., Tony, B., Bigornia, R. R., Palo, J. E., Chatterjee, S., Tan, B. H., Kong, A., Goh, S., Lee, C. -C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. N., Hosny, H., Ashraf, A., Nowruzinia, S., Lotfi, A. H., Zand, F., Nikandish, R., Moghaddam, O. M., Cohen, J., Sold, O., Sfeir, T., Hasan, A. Y., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H. K., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Marshall, J. C., Herridge, M., Fernandez-Medero, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R. G., Jimenez, E., Ryan, A., Prince, D., Edington, J., Van Haren, F., Bersten, A., Hawkins, D. J., Kilminster, M., Sturgess, D., Ziegenfuss, M., O' Connor, S., Lipman, J., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M. M., D'Agostino Dias, M., Lunardi, M. C., Youssef, N. C., Lobo, S., Silva, R., Sales, J. A., Melo, L. M. C., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A. P., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. S., Filho, R. C., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, G. C., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro Castro, L. F., Duque, G. L., Diaz-Guio, D., Benitez, F., Urrego, A. G., Buitrago, R., Ortiz, G., Villalba Gaviria, M. C., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. C., Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., De La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. M., Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. R., Arrazola, F., Juan Francisco, L. L., Namendys-Silva, S. A., Moya, R. G., Hernandez, M., Rodriguez Cadena, D. M., Islas, I. L., Ballesteros Zarzavilla, C. M., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Q., Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Mareque Gianoni, S. M., Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Von Der Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, G., Lahkar, B., Mandal, A. K., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Zirpe, K., Patel, M., Bhavsar, A., Samaddar, D. P., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K. -H., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Gadisseux, P., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., De Waele, J. J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Wittebole, X., Spapen, H., Van Collie, O., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V. -P., Saarinen, K., Durocher, A., Moulront, S., Lepape, A., Losser, M. -R., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J. -Y., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Floccard, B., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Lepoivre, T., Moussa, M. D., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C. -J., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R. A., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, M. G., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S. O., Barry, J., O'Leary, R. A., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., De Oliveira, A. V., Gomes, J., Gaspar, I., Pereira, M. F., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J. J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. K., Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, J. P., Marina, L., Vidal-Cortes, P., Posada, P., Martin-Loeches, I., Guillen, N. M., Palomar, M., Sole-Violan, J., Torres, A., Gonzalez Gallego, M. A., Aguilar, G., Allue, R. M., Argueso, M., Parejo, M., Navarro, M. P., Jose, A., Nin, N., Lerma, F. A., Martinez, O., Lozano, E. T., Lopez, S. A., Perez Granda, M. J., Moreno, S., Llubia, C., Martos, C. D. L. F., Gonzalez-Arenas, P., Fernandez, N. L., Rueda, B. G., Pons, I. E., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, L. I., Quindos, B., Quintano, A., Tebar, M. T., Cardinal, P., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. G., Yus, S., Maseda, E., Berezo, J. A., Pedregosa, A. T., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Matthew, S., Downes, R., Groba, C. B., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Norton, A., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Welters, I., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Alexander, P., Henderson, S., Hargreaves, C., Black, H., Gowda, K., Vincent, J, Ferguson, A, Pickkers, P, Jakob, S, Jaschinski, U, Almekhlafi, G, Leone, M, Mokhtari, M, Fontes, L, Bauer, P, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Lee, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Nishida, O, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Marshall, J, Herridge, M, Fernandez-Medero, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Nanchal, R, Wunderink, R, Jimenez, E, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Hawkins, D, Kilminster, M, Sturgess, D, Ziegenfuss, M, O' Connor, S, Lipman, J, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, D'Agostino Dias, M, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Villalba Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Juan Francisco, L, Namendys-Silva, S, Moya, R, Hernandez, M, Rodriguez Cadena, D, Islas, I, Ballesteros Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Mareque Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, G, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Spapen, H, Van Collie, O, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Lepoivre, T, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Martin-Loeches, I, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, Martos, C, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Haller, A, Matthew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Norton, A, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Alexander, P, Henderson, S, Hargreaves, C, Black, H, and Gowda, K
- Subjects
Male ,umrljivost ,medicine.medical_treatment ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,udc:616.1/.4 ,Critical Care and Intensive Care Medicine ,urologic and male genital diseases ,akutna ledvična odpoved ,renal insufficiency ,law.invention ,0302 clinical medicine ,law ,Oliguria ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,030212 general & internal medicine ,Prospective Studies ,ComputingMilieux_MISCELLANEOUS ,Aged, 80 and over ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,oligurija ,nadomestno zdravljenje ledvične odpovedi ,Acute Kidney Injury ,Middle Aged ,kidney diseases ,Intensive care unit ,urine ,3. Good health ,urine output ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Mortality, Renal replacement therapy, Urine output ,Female ,oliguria ,medicine.symptom ,renal replacement therapy ,Adult ,kidney ,medicine.medical_specialty ,oskrba kritično bolnih ,urin ,Critical Illness ,610 Medicine & health ,Statistics, Nonparametric ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,acute kidney failure ,medicine ,critical illness ,Humans ,Clinical significance ,In patient ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,ddc:610 ,Renal replacement therapy ,izločanje urina ,Mortality ,Urine output ,Aged ,Observational database ,Analysis of Variance ,Critically ill ,business.industry ,Research ,renalna insuficienca ,Médecine pathologie humaine ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,mortality ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,critical care ,bolezni ledvic ,Emergency medicine ,kritično stanje ,ledvica ,business - Abstract
BackgroundUrine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis.ResultsOf the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient—oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged—oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent—oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19–1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97–1.34], p = 0.103).ConclusionsOliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome., 0, info:eu-repo/semantics/published
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- 2019
7. A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit
- Author
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Kotfis, K., Wittebole, X., Jaschinski, U., Sole-Violan, J., Kashyap, R., Leone, M., Nanchal, R., Fontes, Le, Sakr, Y., Vincent, Jl, Tomas, E., Bibonge, Ea, Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, A., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Zbaganu, Gv, Slavcovici, A., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, U., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X., Zhao, X., Li, C., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W., Sin, K., Lee, K., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T., Hata, N., Kobe, Y., Nishida, O., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, Nn, Tai, L., Tony, B., Bigornia, R., Palo, J., Chatterjee, S., Tan, B., Kong, A., Goh, S., Lee, C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Dsicu, Hamdy, An, Hosny, H., Ashraf, A., Mokhtari, M., Nowruzinia, S., Lotfi, A., Zand, F., Nikandish, R., Moghaddam, Om, Cohen, J., Sold, O., Sfeir, T., Hasan, A., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Marshall, J., Herridge, M., Fernandez-Medero, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Bauer, P., Wunderink, R., Jimenez, E., Ryan, A., Prince, D., Edington, J., Haren, F., Bersten, A., Hawkins, Dj, Kilminster, M., Sturgess, D., Ziegenfuss, M., O Connor, S., Lipman, J., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M., Dias, Md, Fontes, L., Lunardi, M., Youssef, N., Lobo, S., Silva, R., Sales, J., Melo, Lmc, Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, Vs, Filho, Rc, Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Gomez, J., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, Gc, Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro, Lc, Duque, Gl, Diaz-Guio, D., Benitez, F., Urrego, Ag, Buitrago, R., Ortiz, G., Gaviria, Mv, Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, Mc, Carlos E. Orellana-Jimenez, Garrido, L., Diaz, O., Resiere, D., Osorio, C., La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, Rm, Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, Dr, Arrazola, F., Francisco, Lj, Liamendys-Silva, Sa, Hernandez, M., Cadena, Dr, Islas, Il, Zarzavilla, Cb, Matos, A., Oyanguren, I., Cerna, J., Sierra, Rq, Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Gianoni, Sm, Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, D., Lahkar, B., Mandal, A., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Gurav, Kz, Patel, M., Bhaysar, A., Samaddar, D., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, U., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Gadisseux, P., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., Waele, J., Rimachi, R., Gusu, D., Decker, K., Mandianga, K., Heytens, L., Spapen, H., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, Jy, Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Floccard, B., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, I., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, Mg, Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S., Barry, J., O Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Penis, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Cate, Jt, Bormans, L., Husada, S., Buise, M., Hoven, B., Reidinga, A., Kuiper, M., Pickkers, P., Kluge, G., Den Boer, S., Kesecioglu, J., Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., Oliveira, Av, Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, A., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, Mk, Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, Ap, Marina, L., Vidal-Cortes, P., Posada, I., Martin-Loeches, Ai, Guillen, Nm, Palomar, M., Sole-Violan, U., Torres, A., Gallego, Mg, Aguilar, G., Allue, Rm, Argueso, M., Parejo, M., Navarro, Mp, Jose, A., Nin, N., Lerma, Fa, Martinez, O., Lozano, Et, Lopez, Sa, Granda, Mp, Moreno, S., Llubia, C., Martos, Cd, Gonzalez-Arenas, P., Fernandez, Nl, Rueda, Bg, Pons, Ie, Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, Li, Quindos, B., Quintano, A., Tebar, M., Cardinal, I., Reyes, A., Rodriguez, A., Abella, A., Del Valle, Sg, Yus, S., Maseda, E., Berezo, U., Pedregosa, At, Laplaza, C., Ferrer, R., Rico-Feijoo, U., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Mathew, S., Downes, R., Groba, Cb, Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, U., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Welters, I., Pearse, R., Hollands, R., Kirk-Bayley, U., Fletcher, N., Bray, B., Brealey, D., Intensive Care, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, UCL - (MGD) Services des soins intensifs, Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], and University of Wisconsin School of Medicine and Public Health
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Adult ,Male ,medicine.medical_specialty ,Critical Illness ,Medizin ,Audit ,Critical Care and Intensive Care Medicine ,Sepsis ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Internal medicine ,Epidemiology ,medicine ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,In patient ,Hospital Mortality ,Prospective Studies ,Mortality ,ComputingMilieux_MISCELLANEOUS ,Outcome ,Aged ,computer.programming_language ,Aged, 80 and over ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,business.industry ,Critically ill ,ICU ,030208 emergency & critical care medicine ,Middle Aged ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,3. Good health ,Hospitalization ,Intensive Care Units ,Increased risk ,030228 respiratory system ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Female ,Observational study ,Icon ,business ,computer - Abstract
Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world., Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ( >16 years ) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - 80 years. Sepsis was defined as infection plus at least one organ failure., Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients 70 years was independently associated with increased risk of dying., Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years. (C) 2019 Elsevier Inc. 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Amisi] Clin Univ Kinshasa, Kinshasa, DEM REP CONGO., [Charra, B.] Chu Ibn Rochd Casablanca, Casablanca, Morocco., [Faroudy, M.] Ibn Sina Hosp, Rabat, Morocco., [Doedens, L.] Chris Hani Baragwanath Acad Hosp, Soweto, South Africa., [Farina, Z.] Grays Hosp, Pietermaritzburg, South Africa., [Adler, D.] Sandton Medi Clin, Sandton, South Africa., [Balkema, C.] Tygerberg Hosp, Cape Town, South Africa., [Kok, A.] Union Hosp Alberton, Alberton, South Africa., [Alaya, S.] Bizerte Hosp, Bizerte, Tunisia., [Gharsallah, H.] Mil Hosp Tunis, Tunis, Tunisia., [Muzha, D.] Natl Trauma Ctr & Mil Hosp, Tirana, Albania., [Temelkov, A.] Alexandrovska Univ Hosp, Sofia, Bulgaria., [Georgiev, G.] Emergency Univ Hosp Pirogov, Sofia, Bulgaria., [Simeonov, G.] Tokuda Hosp Sofia, Sofia, Bulgaria., [Tsaryanski, G.] Uh St Ekaterina Sofia, Sofia, Bulgaria., [Georgiev, S.] Univ Hosp Obstet & Gynaecol, Sofia, Bulgaria., [Seliman, A.] Univ Hosp Sveta Marina Varna, Varna, Bulgaria., [Vrankovic, S.] Gen Hosp Siben, Shibenik, Croatia., [Vucicevic, Z.] Univ Hosp Ctr Sestre Milosrdnice, Zagreb, Croatia., [Gornik, I] Univ Hosp Ctr Zagreb, Zagreb, Croatia., [Barsic, B.] Univ Hosp Infect Dis, Zagreb, Croatia., [Husedzinovic, I] Univ Hosp Dubrava, Zagreb, Croatia., [Pavlik, P.] Ctr Cardiovasc & Transplant Surg, Prague, Czech Republic., [Manak, J.] Charles Univ Hosp, Prague, Czech Republic., [Kieslichova, E.] IKEM, Prague, Czech Republic., [Turek, R.] KNTB Zlin AS, Prague, Czech Republic., [Fischer, M.] Krajska Nemocnice Liberec, Prague, Czech Republic., [Valkova, R.] Masarykova Nemocnice V Usti Labem, Labem, Czech Republic., [Dadak, L.] St Annes Univ Hosp Brno, Brno, Czech Republic., [Dostal, P.] Univ Hosp Haradec Kralove, Haradec Kralove, Czech Republic., [Malaska, J.] Univ Hosp Brno, Brno, Czech Republic., [Hajek, R.] Univ Hosp Olomouc, Olomouc, Czech Republic., [Zidkova, A.] Univ Hosp Plzen, Plzen, Czech Republic., [Lavicka, P.] Charles Univ Hosp Plzen, Plzen, Czech Republic., [Starkopf, J.] Tartu Univ Hosp, Tartu, Estonia., [Kheladze, Z.] Crit Care Med Inst, Gainesville, Georgia., [Chkhaidze, M.] Jo Ann Med Ctr, Tbilisi, Georgia., [Kaloiani, V] Kipshidze Cent Univ Hosp, Tbilisi, Georgia., [Medve, L.] Dr Kenessey Albert Hosp, Balassagyarmat, Hungary., [Sarkany, A.] Fejer Cty St George Teaching Hosp, Szekesfehervar, Hungary., [Kremer, I] Flor Ferenc Cty Hosp, Budapest, Hungary., [Marjanek, Z.] Javorszky Odon Hosp, Vac, Hungary., [Tamasi, P.] Peterfy Hosp Budapest, Budapest, Hungary., [Krupnova, I] Infectol Ctr Latvia, Riga, Latvia., [Vanags, I] Paul Stradins Clin Univ Hosp, Riga, Latvia., [Liguts, V] Riga East Clin Univ Hosp, Riga, Latvia., [Pilvinis, V] Hosp Lithuanian Univ Hlth Sci Kauno Klinikos, Kaunas, Lithuania., [Vosylius, S.] Vilnius Univ Hosp, Vilnius, Lithuania., [Kekstas, G.] HSICU, Vilnius Univ Hosp Santariskiu Clin, Vilnius, Lithuania., [Balciunas, M.] CICU, Vilnius Univ Hosp Santariskiu Clin, Vilnius, Lithuania., [Kolbusz, A.] Csk Mswia, Warsaw, Poland., [Kubler, A.] Med Univ, Wroclaw, Poland., [Mielczarek, B.] Med Univ Wroclaw, Wroclaw, Poland., [Mikaszewska-Sokolewicz, M.] Med Univ Warsaw, Warsaw, Poland., [Kotfis, K.] Pomeranian Med Univ, Szczecin, Poland., [Tamowicz, B.] Reg Hosp Poznan, Poznan, Poland., [Sulkowski, W.] Szpital Powiatowy W Ostrowi Mazowieckiej, Ostrow Mazowiecka, Poland., [Smuszkiewicz, P.] Univ Hosp, Poznan, Poland., [Pihowicz, A.] Wojewodzki Szpital Zakazny, Torun, Poland., [Trejnowska, E.] Wojewodzkie Ctr Med, Warsaw, Poland., [Hagau, N.] Emergency Cty Hosp Cluj, Cluj Napoca, Romania., [Filipescu, D.] Emergency Inst Cardiovasc Dis, Bucharest, Romania., [Droc, G.] Fundeni Clin Inst, Bucharest, Romania., [Lupu, M.] Galati Hosp, Bucharest, Romania., [Nica, A.] Lnbi Prof Dr Matei Bals, Bucharest, Romania., [Stoica, R.] Inst Pulmonol Marius Nasta, Bucharest, Romania., [Tomescu, D.] Inst Clin Fundeni, Bucharest, Romania., [Constantinescu, D.] Sfantul Pantelimon Hosp, Bucharest, Romania., [Zbaganu, G. Valcoreanu] Spitalul Cf 2 Bucuresti, Bucharest, Romania., [Slavcovici, A.] Iuliu Hatieganu Univ Med & Pharm, Teaching Hosp Infect Dis, Cluj Napoca, Romania., [Bagin, V] City Clin Hosp 40, St Petersburg, Russia., [Belsky, D.] City Hosp 40, St Petersburg, Russia., [Palyutin, S.] Clin Hosp NVNV Solovyev, Yaroslavl, Russia., [Shlyapnikov, S.] Emergency Res Inst NA Djanelidze, St Petersburg, Russia., [Bikkulova, D.] Fed Res Ctr Paediat Haematol Oncol & Immunol, Moscow, Russia., [Gritsan, A.] Krasnoyarsk State Med Univ, Krasnoyarsk Reg Hosp, Krasnoyarsk, Russia., [Natalia, G.] Med Assoc Novaya Bolnitsa, Ekaterinburg, Russia., [Makarenko, E.] Mil Med Acad, Ekaterinburg, Russia., [Kokhno, V] Novosibirsk Med Univ, Novosibirsk, Russia., [Tolkach, A.] Omsk Reg Clin Hosp, Omsk, Russia., [Kokarev, E.] Railway Hosp Khabarovsk, Khabarovsk, Russia., [Belotserkovskiy, B.] St Alexy Hosp, St Louis, France., [Zolotukhin, K.] State Dist Hosp, Moscow, Russia., [Kulabukhov, V] Vishnevsky Inst Surg, Moscow, Russia., [Soskic, L.] Clin Ctr Serbia, Clin Cardiac Surg, Belgrade, Serbia., [Palibrk, I] Clin Ctr Serbia, Clin Digest Surg, Belgrade, Serbia., [Jankovic, R.; Jovanovic, B.] Clin Ctr Nis, Clin Vasc Surg, Nish, Serbia., [Pandurovic, M.] Clin Ctr Serbia, Emergency Ctr, Belgrade, Serbia., [Bumbasirevic, V] Clin Ctr Belgrade, Emergency Ctr, Belgrade, Serbia., [Uljarevic, B.] Gen Univ Hosp, Belgrade, Serbia., [Surbatovic, M.] Mil Med Acad, Belgrade, Serbia., [Ladjevic, N.] Urol Hosp, Belgrade, Serbia., [Slobodianiuk, G.] Dist Hosp, Bratislava, Slovakia., [Sobona, V] Fac Hosp, Bratislava, Slovakia., [Cikova, A.] Univ Hosp Bratislava, Hosp Ruzinov ICU, Bratislava, Slovakia., [Gebhardtova, A.] Univ Hosp Ruzinov Bratislava, Bratislava, Slovakia., [Jun, C.] Qingdao Univ, Tertiary Hosp, Qingdao, Shandong, Peoples R China., [Yunbo, S.] Qingdao Univ, Affiliated Hosp, Med Coll, Qingdao, Shandong, Peoples R China., [Dong, U.] Beijing Canc Hosp, Beijing Inst Canc Res, Beijing, Peoples R China., [Feng, S.] Beijing Chaoyang Hosp, Beijing, Peoples R China., [Duan, M.] Beijing Friendship Hosp, Beijing, Peoples R China., [Xu, Y.] Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China., [Xue, X.] Beijing Univ Peoples Hosp, Beijing, Peoples R China., [Gao, T.] Beijing Luhe Hosp, Beijing, Peoples R China., [Xing, X.] Chinese Acad Med Sci, Canc Hosp, Beijing, Peoples R China., [Zhao, X.] China Acad Chinese Med Sci, Guang An Men Hosp, Beijing, Peoples R China., [Li, C.] Peoples Hosp, Chuxiong, Yunnan, Peoples R China., [Gengxihua, G.] Donge Cty Peoples Hosp Shandong Prov, Liaocheng, Shandong, Peoples R China., [Tan, H.] Chinese Acad Med Sci, Fu Wai Hosp, Beijing, Peoples R China., [Xu, J.] Fujian Prov Hosp, Fuzhou, Fujian, Peoples R China., [Jiang, L.] Capital Med Univ, Fuxing Hosp, Beijing, Peoples R China., [Tiehe, Q.] Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China., [Bingyu, Q.] Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China., [Shi, Q.] Xi An Jiao Tong Univ, Coll Med, Xian, Shaanxi, Peoples R China., [Lv, Z.] Kunming Third Peoples Hosp, Kunming, Yunnan, Peoples R China., [Zhang, L.] Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China., [Jingtao, L.] 309th Hosp, Beijing, Peoples R China., [Zhen, Z.] China Med Univ, Hosp 1, Beijing, Peoples R China., [Wang, Z.] Peking Univ, Shougang Hosp, Beijing, Peoples R China., [Wang, T.] Peking Univ, Hosp 3, Beijing, Peoples R China., [Yuhong, L.] Pla Navy Gen Hosp, Beijing, Peoples R China., [Zhai, Q.] Shandong Univ, Qilu Hosp, Jinan, Shandong, Peoples R China., [Chen, Y.] Jiaotong Univ, Affiliated Med Sch, Ruijin Hosp, Shanghai, Peoples R China., [Wang, C.] Shandong Prov Hosp, Jinan, Shandong, Peoples R China., [Jiang, W.] Shanghai 10th Peoples Hosp, Shanghai, Peoples R China., [Ruilan, W.] Shanghai First Peoples Hosp, Shanghai, Peoples R China., [Chen, Y.; Xiaobo, H.] Sichuan Prov Peoples Hosp, Chengdu, Sichuan, Peoples R China., [Ge, H.] Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China., [Yan, T.] Affiliated Guiyang Med Coll, Guiyang, Guizhou, Peoples R China., [Yuhui, C.] Fudan Univ, Peoples Hosp Shanghai 5, Shanghai, Peoples R China., [Zhang, J.] Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China., [Jian-Hong, F.] Suzhou Univ, Affiliated Hosp 1, Suzhou, Peoples R China., [Zhu, H.] Xinjiang Med Univ, Affiliated Hosp 1, Urumqi, Peoples R China., [Huo, F.; Wang, Y.] Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China., [Li, C.] First Peoples Hosp Kunming, Kunming, Yunnan, Peoples R China., [Zhuang, M.] Gen Hosp Shenyang Mil Reg, Shenyang, Liaoning, Peoples R China., [Ma, Z.] Peoples Hosp Cangzhou, Cangzhou, Peoples R China., [Sun, J.] Jilin Univ, Hosp 2, Changchun, Jilin, Peoples R China., [Liuqingyue, L.] Second Peoples Hosp Liaocheng City Shandong Prov, Liaocheng, Shandong, Peoples R China., [Yang, M.] Third Xiangya Hosp, Changsha, Hunan, Peoples R China., [Meng, J.] Tongde Hosp Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China., [Ma, S.] Tongji Univ, Shanghai East Hosp, Shanghai, Peoples R China., [Kang, Y.] West China Hosp, Scu, Peoples R China., [Yu, L.] Wuhan Ctr Hosp, Wuhan, Hubei, Peoples R China., [Peng, Q.] Xiangya Hosp, Changsha, Hunan, Peoples R China., [Wei, Y.] Yantai Yuhuangding Hosp, Yantai, Peoples R China., [Zhang, W.] Yantaishan Hosp, Yantai, Shandong, Peoples R China., [Sun, R.] Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China., [Yeung, A.] Pamela Youde Nethersole Eastern Hosp, Hong Kong, Peoples R China., [Wan, W.] Princess Margaret Hosp, Hong Kong, Peoples R China., [Sin, K.] Queen Elizabeth Hosp, Hong Kong, Peoples R China., [Lee, K.] United Christian Hosp Hong Kong SAR, Hong Kong, Peoples R China., [Wijanti, M.] Anestesi, Yogyakarta, Indonesia., [Widodo, U.] Pku Muhammadiyah Bantu, Yogyakarta, Indonesia., [Samsirun, H.] Rd Mattaher Hosp Jambi, Jambi City, Indonesia., [Sugiman, T.] Rumah Sakit Pantai Lndah Kapuk, North Jakarta, Indonesia., [Wisudarti, C.] Sardjito Hosp, Yogyakarta, Indonesia., [Maskoen, T.] Sch Med Unpad, Hasan Sadikin Hosp, Bandung, Indonesia., [Hata, N.] Nippon Med Sch, Chiba Hokusoh Hosp, Inzai, Japan., [Kobe, Y.] Chiba Univ Hosp, Chiba, Japan., [Nishida, O.] Fujita Hlth Univ, Sch Med, Toyoake, Aichi, Japan., [Miyazaki, D.] Japanese Red Cross Maebashi Hosp, Maebashi, Gumma, Japan., [Nunomiya, S.] Jichi Med Univ Hosp, Shimotsuke, Japan., [Uchino, S.] Jikei Univ, Sch Med, Tokyo, Japan., [Kitamura, N.] Kimitsu Chuo Hosp, Kisarazu, Japan., [Yamashita, K.] Kochi Med Sch, Nankoku, Kochi, Japan., [Hashimoto, S.] Kyoto Prefectural Univ Med, Kyoto, Japan., [Fukushima, H.] Nara Med Univ Hosp, Kashihara, Nara, Japan., [Adib, N. Nik] Hosp Sultanah Nur Zahirah, Kuala Terengganu, Terengganu, Malaysia., [Tai, L.] Kuala Lumpur Hosp, Kuala Lumpur, Malaysia., [Tony, B.] Queen Elizabeth Hosp 2, Kota Kinabalu, Malaysia., [Bigornia, R.] Cebu Velez Gen Hosp, Cebu, Philippines., [Bigornia, R.] Perpetual Succour Hosp, Cebu, Philippines., [Palo, J.] Med City, Pasig, Philippines., [Chatterjee, S.] Alexandra Hosp, Singapore, Singapore., [Tan, B.] Natl Univ Hlth Syst, Singapore, Singapore., [Kong, A.] Singapore Gen Hosp, Singapore, Singapore., [Goh, S.] Tan Tock Seng Hosp, Singapore, Singapore., [Lee, C.] Natl Taiwan Univ Hosp, Taipei, Taiwan., [Pothirat, C.] Chiaingmai Univ, Maharaj Nakorn Chiangmai Hosp, Chiang Mai, Thailand., [Khwannimit, B.] Prince Songkla Univ, Hat Yai, Thailand., [Theerawit, P.] Ramathibodi Hosp, Bangkok, Thailand., [Pornsuriyasak, P.] Ramathibodi Hosp, Somdech Phra Debaratana Med Ctr, Bangkok, Thailand., [Piriyapatsom, A.] Mahidol Univ, Siriraj Hosp, Bangkok, Thailand., [Mukhtar, A.] Cairo Univ, Giza, Egypt., [Dsicu] Demerdash Surg Intens Care Unit, Cairo, Egypt., [Hamdy, A. Nabil] Ain Shams Fac Med, Cairo, Egypt., [Hosny, H.] Zaitoun Specialized Hosp, Cairo, Egypt., [Ashraf, A.] Gums, Tehran, Iran., [Mokhtari, M.] Sbums, Imam Hossein Hosp, Tehran, Iran., [Nowruzinia, S.] Imamreza Hosp, Mashhad, Razavi Khorasan, Iran., [Lotfi, A.] Laleh Hosp, Tehran, Iran., [Zand, F.] Shiraz Anesthesiol & Crit Care Res Ctr, Shiraz, Iran., [Nikandish, R.] Shiraz Univ Med Sci, Shiraz, Iran., [Moghaddam, O. Moradi] Tehran Med Sci Univ, Tehran, Iran., [Cohen, J.] Rabin Med Ctr, Petah Tiqwa, Israel., [Sold, O.] Sourasky Tel Aviv Med Ctr, Tel Aviv, Israel., [Sfeir, T.] Ctr Hosp Nord, Ettelbruck, Luxembourg., [Hasan, A.] Sohar Hosp, Sohar, Oman., [Abugaber, D.] Specialized Arab Hosp, Nablus, Palestine., [Ahmad, H.] Almana Gen Hosp, Khobar, Saudi Arabia., [Tantawy, T.] KFSHRC, Riyadh, Saudi Arabia., [Baharoom, S.] King Abdulaziz Med City Riyadh, Riyadh, Saudi Arabia., [Algethamy, H.] King Abdulaziz Univ, Jeddah, Saudi Arabia., [Amr, A.] King Saud Med City, Riyadh, Saudi Arabia., [Almekhlafi, G.] Riyadh Mil Hosp, Riyadh, Saudi Arabia., [Coskun, R.] Erciyes Univ, Med Fac, Kayseri, Turkey., [Sungur, M.] Erciyes Univ, Med Sch, Kayseri, Turkey., [Cosar, A.] Gulhane Mil Med Acad, Ankara, Turkey., [Gucyetmez, B.] Int Hosp, Istanbul, Turkey., [Demirkiran, O.] Istanbul Univ, Cerrahpasa Med Sch Hosp, Istanbul, Turkey., [Senturk, E.] Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey., [Ulusoy, H.] Karadeniz Tech Univ, Med Fac, Trabzon, Turkey., [Atalan, H.] Mem Atasehir Hosp, Istanbul, Turkey., [Serin, S.] Pamukkale Univ, Denizli, Turkey., [Kati, I] Yuzuncu Yil Univ, Med Fac, Van, Turkey., [Alnassrawi, Z.] Dubai Hosp, Dubai, U Arab Emirates., [Almemari, A.] Mafraq Hosp, Abu Dhabi, U Arab Emirates., [Krishnareddy, K.] Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates., [Kashef, S.] Tawam Hosp, Al Ain, U Arab Emirates., [Alsabbah, A.] City Hosp, Dubai, U Arab Emirates., [Poirier, G.] Hop Charles Lemoyne, Longueuil, PQ, Canada., [Marshall, J.] St Michaels Hosp, Toronto, ON, Canada., [Herridge, M.] Toronto Gen Hosp, Toronto, ON, Canada., [Herridge, M.] Toronto Western Hosp, Toronto, ON, Canada., [Fernandez-Medero, R.] San Juan Hosp, San Juan, PR USA., [Fulda, G.] Christiana Care Hlth Syst, Newark, DE USA., [Banschbach, S.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA., [Quintero, J.] El Camino Hosp, Mountain View, CA USA., [Schroeder, E.] George Washington Hosp, Washington, DC USA., [Sicoutris, C.] Hosp Univ Penn, Philadelphia, PA 19104 USA., [Gueret, R.] John H Stroger Hosp Cook Cty, Chicago, IL USA., [Kashyap, R.] Mayo Clin, CCM, Rochester, MN USA., [Bauer, P.] Mayo Clin, PCC, Rochester, MN USA., [Nanchal, R.] Med Coll Wisconsin, Milwaukee, WI 53226 USA., [Wunderink, R.] Northwestern Mem Hosp, Chicago, IL 60611 USA., [Jimenez, E.] Orlando Reg Med Ctr Inc, Orlando, FL USA., [Ryan, A.] Washington Hosp Ctr, Washington, DC 20010 USA., [Ryan, A.] Washington Hosp Ctr, 2H, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, 2G, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, 3H, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, 3G, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, 4H, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, CVRR, Washington, DC USA., [Prince, D.] Armadale Hlth Serv, Mount Nasura, WA, Australia., [Edington, J.] Bendigo Hosp, Bendigo, Vic, Australia., [Van Haren, F.] Canberra Hosp, Canberra, ACT, Australia., [Bersten, A.] Flinders Med Ctr, Bedford Pk, SA, Australia., [Hawkins, D. J.] Joondalup Hlth Campus, Joondalup, WA, Australia., [Kilminster, M.] Lismore Base Hosp, Lismore, NSW, Australia., [Sturgess, D.] Mater Adult Hosp, South Brisbane, Qld, Australia., [Ziegenfuss, M.] Prince Charles Hosp, Brisbane, Qld, Australia., [O'Connor, S.] Royal Adelaide Hosp, Adelaide, SA, Australia., [Lipman, J.] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia., [Campbell, L.] Royal Darwin Hosp, Tiwi, NT, Australia., [Mcallister, R.] Royal Hobart Hosp, Hobart, Tas, Australia., [Roberts, B.] Sir Charles Gairdner Hosp, Nedlands, WA, Australia., [Williams, P.] Queen Elizabeth Hosp, Woodville, SA, Australia., [Parke, R.] Auckland Dist Hlth Board, Auckland, New Zealand., [Seigne, P.] Christchurch Hosp, Christchurch, New Zealand., [Freebairn, R.] Hawkes Bay Hosp, Hastings, New Zealand., [Nistor, D.] Palmerston North Hosp, Midcent Hlth, Palmerston North, New Zealand., [Oxley, C.] Middlemore Hosp, Auckland, New Zealand., [Young, P.] Wellington Hosp, Wellington, New Zealand., [Valentini, R.] Cemic, Buenos Aires, DF, Argentina., [Wainsztein, N.] Fleni, Buenos Aires, DF, Argentina., [Comignani, P.] Hosp Aleman, Buenos Aires, DF, Argentina., [Casaretto, M.] Hosp Cent San Isidro, Buenos Aires, DF, Argentina., [Sutton, G.] Hosp Fernandez, Buenos Aires, DF, Argentina., [Villegas, P.] Hosp Francisco Lopez Lima Area Programa Gen Roca, Gen Roca, Argentina., [Galletti, C.] Sanatorio Allende, Cordoba, Argentina., [Neira, J.] Sanatorio Trinidad Palermo, Buenos Aires, DF, Argentina., [Rovira, D.] Sanatorio Julio Corzo Rosario, Rosario, Santa Fe, Argentina., [Hidalgo, J.] Karl Heusner Mem Hosp, Belize City, Belize., [Hidalgo, J.] Belize Healthcare Partner, Belize City, Belize., [Sandi, F.] Hosp Obrero 1, La Paz, Bolivia., [Caser, E.] Cias Unimed Vitoria, Vitoria, ES, Brazil., [Thompson, M.] Evangelical Hosp Cachoeiro De Itapemirim, Cachoeiro De Itapemirim, Brazil., [D'agostino Dias, M.] Hosp 9 Julho, Sao Paulo, Brazil., [Fontes, L.] Hosp Alcides Carneiro, Petropolis, Brazil., [Lunardi, M.] Hosp Clin Luzia De Pinho Melo, Mogi Das Cruzes, Brazil., [Youssef, N.] Hosp Nacoes Curitiba, Curitiba, Parana, Brazil., [Lobo, S.] Hosp Base Famerp, Sao Jose Do Rio Preto, Brazil., [Silva, R.] Hosp Clin Niteroi, Niteroi, RJ, Brazil., [Sales Jr, J.] Hosp Clin Padre Miguel, Rio De Janeiro, Brazil., [Madeira Campos Melo, L.] Hosp Terapia Intens, Sao Paulo, Brazil., [Oliveira, M.] Hosp Trabalhador, Curitiba, Parana, Brazil., [Fonte, M.] Hosp Esperanza, Olinda, PE, Brazil., [Grion, C.] Hosp Evangel Londrina, Londrina, Brazil., [Feijo, C.] Hosp Geral Fortaleza, Fortaleza, Ceara, Brazil., [Rezende, V] Hosp Geral Roraima, Boa Vista, Brazil., [Assuncao, M.] Hosp Israelita Albert Einstein, Sao Paulo, Brazil., [Neves, A.] Hosp Mater Dei, Belo Horizonte, MG, Brazil., [Gusman, P.; Dalcomune, D.] Hosp Meridional, Cariacica, ES, Brazil., [Teixeira, C.] Hosp Moinhos Vento, Porto Alegre, RS, Brazil., [Kaefer, K.] Hosp Municipal Ruth Cardoso, Balneario, Brazil., [Maia, I] Hosp Nereu Ramos, Florianopolis, SC, Brazil., [Souza Dantas, V] Hosp Pasteur, Rio De Janeiro, Brazil., [Costa Filho, R.] Hosp Pro Cardiaco, Rio De Janeiro, Brazil., [Amorim, F.] Hosp Reg Samambaia, Brasilia, DF, Brazil., [Assef, M.] Hosp Reg Hans Dieter Schmidt, Joinville, Brazil., [Schiavetto, P.] Hosp Santa Casa Campo Mourao, Campo Mourao, PR, Brazil., [Houly, J.] Hosp Santa Paula, Sao Paulo, SP, Brazil., [Houly, J.] Hosp Santapaula, Sao Paulo, Brazil., [Bianchi, F.] Hosp Sao Jose Avai, Itaperuna, RJ, Brazil., [Dias, F.] Hosp Sao Lucas Pucrs, Porto Alegre, RS, Brazil., [Avila, C.] Hosp Sao Vicente Paula, Rio De Janeiro, RJ, Brazil., [Gomez, J.] Hosp Sao Vicente Paulo, Rio De Janeiro, Brazil., [Rego, L.] Hosp Saude Mulher, Belem, Para, Brazil., [Castro, P.] Hosp Tacchini, Bento Goncalves, RS, Brazil., [Passos, J.] Hosp Unimed Costa Do Sol Macae Rj, Macae, RJ, Brazil., [Mendes, C.] Hosp Univ Ufpb Joao Pessoa, Joao Pessoa, Paraiba, Brazil., [Grion, C.] Hosp Univ Londrina, Londrina, Brazil., [Colozza Mecatti, G.] Hosp Univ Sao Francisco, Braganca Paulista, SP, Brazil., [Ferrreira, M.] Santa Casa Caridade Diamantina, Diamantina, MG, Brazil., [Irineu, V] Santa Casa Misericordia Tatui, Tatui, Brazil., [Guerreiro, M.] Sao Francisco de Paula Hosp, Sao Francisco De Paula, RS, Brazil., [Ugarte, S.] Clin Indisa, Providencia, Chile., [Tomicic, V] Clin Las Lilas, Providencia, Chile., [Godoy, C.] Hosp Carlos Van Buren, Valparaiso, Chile., [Samaniego, W.] Hosp Trabajador Santiago, Santiago, Chile., [Escamilla, I] Hosp El Pino, San Bernardo, Chile., [Escamilla, I] Hosp Mutual De Seguridad, Santiago, Chile., [Castro Castro, L.] Ctr Med Imbanaco, Valle Del Cauca, Colombia., [Libreros Duque, G.] Clin Colombia Cali, Cali, Colombia., [Diaz-Guio, D.] Clin Del Cafe, Armenia, Colombia., [Benitez, F.] Clin La Estancia SA, Popayan, Colombia., [Guerra Urrego, A.] Clin Medellin, Medellin, Colombia., [Buitrago, R.] Fdn Clin Shaio, Bogota, Colombia., [Ortiz, G.] Hosp Santa Clara, Bogota, Colombia., [Villalba Gaviria, M.] Hosp Univ Fdn Santa Fe De Bogota, Bogota, Colombia., [Salas, D.] Calderon Guardia Hosp, San Jose, Costa Rica., [Ramirez-Arce, J.] Hosp Dr Rafael Angel Varlderon Guardia Ccss, San Jose, Costa Rica., [Salgado, E.] Clin La Merced, Quito, Ecuador., [Morocho, D.] Hosp Eugenio Espejo, Quito, Ecuador., [Vergara, J.] Hosp Luis Vernaza, Quito, Ecuador., [Chung Sang, M.] Shdug Sistema Hosp Docente De La Univ Guayaquil, Quito, Ecuador., [Orellana-Jimenez, C.] Gen Hosp, San Salvador, El Salvador., [Garrido, L.] Hosp Ctr Med, Guatemala City, Guatemala., [Diaz, O.] Inst Hondureno Seguro Social, La Ceiba, Honduras., [Resiere, D.] Ctr Hosp Univ Ft De France, Fort De France, Martinique, France., [Osorio, C.] Ctr Estatal Cuidados Crit, Salamanca, Mexico., [De La Vega, A.] Ctr Med Nacl 20 Noviembre Issste, Mexico City, DF, Mexico., [Carrillo, R.] Fdn Clin Med Sur, Mexico City, DF, Mexico., [Sanchez, V] Hosp San Jose TEC Monterrey, Monterrey, Mexico., [Villagomez, A.] Hosp 1 Octubre, Issste, Mexico., [Martinez Zubieta, R.] Hosp Espanol Mexico, Mexico City, DF, Mexico., [Sandia, M.] Hosp Gen Ajusco Medio, Mexico City, DF, Mexico., [Zalatiel, M.] Hosp Gen Guadalupe Victoria, Texcoco, Mexico., [Poblano, M.] Hosp Juarez Mexico, Mexico City, DF, Mexico., [Rodriguez Gonzalez, D.] Hosp Civil Guadalajara, Hspitaljuan I Menchaca, Guadalajara, Jalisco, Mexico., [Arrazola, F.; Juan Francisco, L.] Inst Mexicano Seguro Social, Mexico City, DF, Mexico., [Liamendys-Silva, S. A.] Inst Nacl Cancerol, Mexico City, DF, Mexico., [Hernandez, M.] ISSSTE Guerra Moya, Mexico City, DF, Mexico., [Hernandez, M.] Med Ctr ISSEMYM Toluca, Mexico City, DF, Mexico., [Rodriguez Cadena, D.] Mixta, Mexico City, DF, Mexico., [Lopez Islas, I.] Secretaria Salud Dist Fed, Mexico City, DF, Mexico., [Ballesteros Zarzavilla, C.] Hosp Santo Comas, Panama City, Panama., [Matos, A.] Social Secur Hosp, La Chorrera, Panama., [Oyanguren, I] Clin Anglo Amer, Lima, Peru., [Cerna, J.] Essalud, Lima, Peru., [Quispe Sierra, R.] Hosp Nacl Dos De Mayo, Lima, Peru., [Jimenez, R.] Hosp Rebagliati, Lince Dist, Peru., [Castillo, L.] Inst Nacl Enfermedades Neoplas, Surquillo, Peru., [Ocal, R.] Gulhane Med Fac, Istanbul, Turkey., [Sencan, A.] Izmir Ataturk Educ & Res Hosp, Izmir, Turkey., [Gianoni, S. Mareque] CAMS, Montevideo, Uruguay., [Deicas, A.] CASMU, Montevideo, Uruguay., [Hurtado, J.] Hosp Espanol Asse, Montevideo, Uruguay., [Burghi, G.] Hosp Maciel, Montevideo, Uruguay., [Martinelli, A.] Ctr Med Caracas, Caracas, Venezuela., [Von der Osten, I] Hosp Miguel Perez Carreno, Caracas, Venezuela., [Du Maine, C.] MSF Trauma Hosp Kunduz, Kunduz, Afghanistan., [Bhattacharyya, M.] Amri Hosp, Kolkata, India., [Bandyopadhyay, S.] Amri Hosp Salt Lake, Kolkata, W Bengal, India., [Yanamala, S.] Apollo Hosp, Hyderabad, India., [Gopal, P.] Apollo Hosp, Bangalore, Karnataka, India., [Sahu, S.] Apollo Hosp, Bhubaneswar, India., [Ibrahim, M.] Apollo Special Hosp, Chennai, Tamil Nadu, India., [Rathod, D.] Asian Heart Inst, Mumbai, Maharashtra, India., [Mukundan, N.] Baby Mem Hosp Ltd, Calicut, Kerala, India., [Dewan, A.] Batra Hosp & Mrc, New Delhi 110062, India., [Amin, P.] Bombay Hosp Inst Med Sci, Mumbai, Maharashtra, India., [Samavedam, S.] Care Hosp, Hyderabad, India., [Shah, B.] Cims Hosp, Ahmadabad, Gujarat, India., [Gurupal, D.] Columbiaasia Hosp, Mysore, Karnataka, India., [Lahkar, B.] Dispur Hosp, Gauhati, India., [Mandal, A.] Fortis Hosp, Bangalore, Karnataka, India., [Sircar, M.] Fortis Hosp, Noida, India., [Ghosh, S.] Fortis Escorts Hosp, Faridabad, India., [Balasubramani, V] Ganga Med Ctr & Hosp P Ltd, Coimbatore, Tamil Nadu, India., [Kapadia, F.] Hinduja Hosp, Mumbai, Maharashtra, India., [Vadi, S.] KDAH, Mumbai, Maharashtra, India., [Nair, K.] Kerala Inst Med Sci, RMCC, Thiruvananthapuram, Kerala, India., [Tripathy, S.] Kalinga Inst Med Sci, DTEM, Bhubaneswar, Odisha, India., [Nandakumar, S.] Kovai Med Ctr & Hosp, Coimbatore, Tamil Nadu, India., [Sharma, J.] Medanta Medic, Gurgaon, India., [Kar, A.] Med Superspecialty Hosp, Kolkata, W Bengal, India., [Jha, S.] Metro Heart Inst Multispecial, Faridabad, India., [Gurav, K. Zirpe] Ruby Hall Pune, Pune, Maharashtra, India., [Patel, M.] Saifee Hosp, Mumbai, Maharashtra, India., [Bhaysar, A.] Spandan Multispecial Hosp, Vadodara, India., [Samaddar, D.] Tata Main Hosp, Jamshedpur, Jharkhand, India., [Kulkarni, A.] Tata Mem Hosp, Mumbai, Maharashtra, India., [Hashmi, M.] Aga Khan Univ, Karachi, Pakistan., [Ali, W.] Hearts Int Hosp, Rawalpindi, Pakistan., [Nadeem, S.] Liaquat Natl Hosp, Karachi, Pakistan., [Indraratna, K.] Sri Jayewardenepura Gen Hosp, Sri Jayawardenepura Kott, Sri Lanka., [Margarit, A.] Hosp Nostra Senyora Meritxell, Les Escaldes, Andorra., [Urbanek, P.] Akh Wien, Vienna, Austria., [Schlieber, J.] Allgemeines & Orthopad Landeskrankenhaus Stolzalp, Stolzalpe, Austria., [Reisinger, J.] Barmherzige Schwestern Linz, Linz, Austria., [Auer, U.] Gen Hosp Braunau, Braunau, Austria., [Hartjes, A.] Krankenhaus D Barmherzigen Schwestern Ried II, Ried Im Innkreis, Austria., [Lerche, A.] Krankenhaus Floridsdorf, Vienna, Austria., [Janous, T.] LK Gmund Waidhofen Thaya Zwettl, Standort Zwettl, Austria., [Kink, E.] LKH Horgas Enzenbach, Gratwein, Austria., [Krahulec, W.] LKH West, Graz, Austria., [Smolle, K.] Univ Hosp, Graz, Austria., [Van der Schueren, M.] AZ Groeninge Kortrijk, Kortrijk, Belgium., [Thibo, P.] AZ Jan Palfijn Gent, Ghent, Belgium., [Vanhoof, M.] AZ Turnhout, Turnhout, Belgium., [Ahmet, I] Bracops Anderlecht, Anderlecht, Belgium., [Gadisseux, P.] Ctr Hosp Mouscron, Mouscron, Belgium., [Dufaye, P.] CH Peltzer La Tourelle, Verviers, Belgium., [Jacobs, O.] Chirec Edith Cavell, Auderghem, Belgium., [Fraipont, V] CHR Citadelle, Liege, Belgium., [Biston, P.] CHU Charleroi, Charleroi, Belgium., [Dive, A.] CHU Mt Godinne, Yvoir, Belgium., [Bouckaert, Y.] CHU Tivoli, La Louviere, Belgium., [Gilbert, E.] CHwapi, Tournai, Belgium., [Gressens, B.] Clin St Pierre Ottignies, Ottignies, Belgium., [Pinck, E.] Clin Maternite St Elisabeth, Namur, Belgium., [Collin, V] Clin Europe St Michel, Etterbeek, Belgium., [Vincent, J. L.] Erasme Univ Hosp, Anderlecht, Belgium., [De Waele, J.] Ghent Univ Hosp, Ghent, Belgium., [Rimachi, R.] Moliere Hosp, Forest, Belgium., [Gusu, D.] Notre Dame, Brussels, Belgium., [De Decker, K.] Onze Lieve Vrouw Hosp, Aalst, Belgium., [Mandianga, K.] Ixelles Hosp, Ixelles, Belgium., [Heytens, L.] Sint Augustinus, Antwerp, Belgium., [Wittebole, X.] St Luc Univ Hosp UCL, Brussels, Belgium., [Spapen, H.] UZ Brussel, Brussels, Belgium., [Olivier, V] Vivalia Site Libramt, Libramont, Belgium., [Vandenheede, W.] VZW Gezondheidszorg Oostkust Knokke Heist, Knokke Heist, Belgium., [Rogiers, P.] ZNA Middelheim, Antwerp, Belgium., [Kolodzeike, P.] Herning Hosp, Herning, Denmark., [Kruse, M.] Hjoerring Hosp, Hjorring, Denmark., [Andersen, T.] Vejle Hosp, Vejle, Denmark., [Harjola, V] Helsinki Univ Cent Hosp, Helsinki, Finland., [Saarinen, K.] Seinajoki Cent Hosp, Seinajoki, Finland., [Leone, M.] Aix Marseille Univ, Hop Nord, Marseille, France., [Durocher, A.] Calmette Hosp, Lille, France., [Moulront, S.] Ctr Hosp Dunkerque, Dunkerque, France., [Lepape, A.] Ctr Hosp Lyon Sud, Lyon, France., [Losser, M.] CHU Nancy Brabois, Nancy, France., [Cabaret, P.] CH St Philibert, GHICL, Lille, France., [Kalaitzis, E.] CHR Dax, Dax, France., [Zogheib, E.] CHU Amiens, Amiens, France., [Charve, P.] CHU Dijon, Dijon, France., [Francois, B.] CHU Dupuytren, Limoges, France., [Lefrant, J. Y.] CHU Nimes, Nimes, France., [Beilouny, B.] Ctr Hosp Troyes, Troyes, France., [Forceville, X.] Ctr Hosp Meaux, Grp Hosp Est Francilien, Meaux, France., [Misset, B.] Grp Hosp Paris St Joseph, Paris, France., [Jacobs, F.] Hop Antoine Beclere, Clamart, France., [Floccard, B.] Hop Edouard Herriot, Lyon, France., [Payen, D.] Hop Lariboisere, AP HP, Paris, France., [Wynckel, A.] Hop Maison Blanche, Reims, France., [Castelain, V] Hop Univ Strasbourg, Strasbourg, France., [Faure, A.] Hosp Civils Lyon, Lyon, France., [Lavagne, P.] CHU Grenoble, Grenoble, France., [Thierry, I] CHU Nantes, Nantes, France., [Moussa, M.] CHRU Lille, Reanimat Chirurg Cardiovasc, Lille, France., [Vieillard-Baron, A.] Univ Hosp Ambroise Pare, Boulogne, France., [Durand, M.] Univ Hosp Grenoble, La Tronche, France., [Gainnier, M.] Univ Hosp Marseille, Marseille, France., [Ichai, C.] Univ Nice, Nice, France., [Arens, S.] Alexianer Krefeld Gmbh, Krefeld, Germany., [Hoffmann, C.] Charite Hochschulmed Berlin, Berlin, Germany., [Kaffarnik, M.] Charite, Berlin, Germany., [Scharnofske, C.] Diakoniekrankenhaus Henriettenstiftung Gmbh, Hannover, Germany., [Voigt, I] Elisabeth Krankenhaus Essen, Essen, Germany., [Peckelsen, C.] Munich Municipal Hosp Grp, Harlaching Hosp, Munich, Germany., [Weber, M.] Helios St Johannes Klin, Duisburg, Germany., [Gille, J.] Hosp St Georg Leipzig, Leipzig, Germany., [Lange, A.] Klin Hennigsdorf Oberhavel Kliniken Gmbh, Hennigsdorf, Germany., [Schoser, G.] Klin Tettnang, Tettnang, Germany., [Sablotzki, A.] Klinikum St Georg Leipzig, Leipzig, Germany., [Jaschinski, U.; Bluethgen, A.] Klinikum Augsburg, Augsburg, Germany., [Vogel, F.] Klinikum Bremen Mitte, Bremen, Germany., [Tscheu, A.] Klinikum Bremen Ost, Bremen, Germany., [Fuchs, T.] Klinikum Heidenheim, Heidenheim, Germany., [Wattenberg, M.] Klinikum Links Weser Gmbh, Bremen, Germany., [Helmes, T.] Klinikum Luedenscheid, Luedenscheid, Germany., [Scieszka, S.] Krankenhaus Neuwerk, Monchengladbach, Germany., [Heintz, M.] Marienkrankenhaus Schwerte, Schwerte, Germany., [Sakka, S.] Med Ctr Cologne Merheim, Cologne, Germany., [Kohler, J.] Schwarzwald Baar Klinikum Villingen Schwenningen, Villingen Schwenningen, Germany., [Fiedler, F.] St Elisabeth Krankenhaus Koln Hohenlind, Cologne, Germany., [Danz, M.] St Martinus Hosp Olpe, Olpe, Germany., [Sakr, Y.] Uniklinikum Jena, Jena, Germany., [Riessen, R.] Univ Klinikum Tubingen, Tubingen, Germany., [Kerz, T.] Univ Med Mainz, Mainz, Germany., [Kersten, A.] Univ Hosp Aachen, CPACC, Aachen, Germany., [Tacke, F.] Univ Hosp Aachen, DMIII, Aachen, Germany., [Marx, G.] Univ Hosp Aachen, OIC, Aachen, Germany., [Volkert, T.] Univ Hosp Muenster, Munster, Germany., [Schmutz, A.] Univ Med Ctr Freiburg, Fr
- Published
- 2019
8. Frequency of buccopalpebral reflex in Parkinson’s disease: EP4137
- Author
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Eser, H., Kutlu, G., Ocal, R., and Inan, L. E.
- Published
- 2014
9. Clinical results of carotid artery stenting versus carotid endarterctomy; a single center experience: EP1122
- Author
-
Aknc, T., Derle, E., Kibaroglu, S., Ocal, R., Harman, A., Kural, F., Kilinç, M., Akay, H. T., Can, U., and Benli, U. S.
- Published
- 2014
10. A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit
- Author
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Kotfis, Katarzyna Wittebole, Xavier Jaschinski, Ulrich and Sole-Violan, Jordi Kashyap, Rahul Leone, Marc Nanchal, Rahul and Fontes, Luis E. Sakr, Yasser Vincent, Jean-Louis Tomas, E. Bibonge, E. Amisi Charra, B. Faroudy, M. Doedens, L. and Farina, Z. Adler, D. Balkema, C. Kok, A. Alaya, S. and Gharsallah, H. Muzha, D. Temelkov, A. Georgiev, G. and Simeonov, G. Tsaryanski, G. Georgiev, S. Seliman, A. and Vrankovic, S. Vucicevic, Z. Gornik, I Barsic, B. and Husedzinovic, I Pavlik, P. Manak, J. Kieslichova, E. and Turek, R. Fischer, M. Valkova, R. Dadak, L. Dostal, P. and Malaska, J. Hajek, R. Zidkova, A. Lavicka, P. and Starkopf, J. Kheladze, Z. Chkhaidze, M. Kaloiani, V and Medve, L. Sarkany, A. Kremer, I Marjanek, Z. Tamasi, P. and Krupnova, I Vanags, I Liguts, V Pilvinis, V and Vosylius, S. Kekstas, G. Balciunas, M. Kolbusz, A. and Kubler, A. Mielczarek, B. Mikaszewska-Sokolewicz, M. Kotfis, K. Tamowicz, B. Sulkowski, W. Smuszkiewicz, P. Pihowicz, A. Trejnowska, E. Hagau, N. Filipescu, D. Droc, G. and Lupu, M. Nica, A. Stoica, R. Tomescu, D. Constantinescu, D. Zbaganu, G. Valcoreanu Slavcovici, A. Bagin, V and Belsky, D. Palyutin, S. Shlyapnikov, S. Bikkulova, D. and Gritsan, A. Natalia, G. Makarenko, E. Kokhno, V Tolkach, A. Kokarev, E. Belotserkovskiy, B. Zolotukhin, K. and Kulabukhov, V Soskic, L. Palibrk, I Jankovic, R. and Jovanovic, B. Pandurovic, M. Bumbasirevic, V Uljarevic, B. and Surbatovic, M. Ladjevic, N. Slobodianiuk, G. Sobona, V and Cikova, A. Gebhardtova, A. Jun, C. Yunbo, S. Dong, U. Feng, S. Duan, M. Xu, Y. Xue, X. Gao, T. and Xing, X. Zhao, X. Li, C. Gengxihua, G. Tan, H. Xu, J. Jiang, L. Tiehe, Q. Bingyu, Q. Shi, Q. Lv, Z. and Zhang, L. Jingtao, L. Zhen, Z. Wang, Z. Wang, T. and Yuhong, L. Zhai, Q. Chen, Y. Wang, C. Jiang, W. and Ruilan, W. Chen, Y. Xiaobo, H. Ge, H. Yan, T. Yuhui, C. Zhang, J. Jian-Hong, F. Zhu, H. Huo, F. Wang, Y. and Li, C. Zhuang, M. Ma, Z. Sun, J. Liuqingyue, L. and Yang, M. Meng, J. Ma, S. Kang, Y. Yu, L. Peng, Q. and Wei, Y. Zhang, W. Sun, R. Yeung, A. Wan, W. Sin, K. Lee, K. Wijanti, M. Widodo, U. Samsirun, H. and Sugiman, T. Wisudarti, C. Maskoen, T. Hata, N. Kobe, Y. and Nishida, O. Miyazaki, D. Nunomiya, S. Uchino, S. and Kitamura, N. Yamashita, K. Hashimoto, S. Fukushima, H. and Adib, N. Nik Tai, L. Tony, B. Bigornia, R. Palo, J. and Chatterjee, S. Tan, B. Kong, A. Goh, S. Lee, C. and Pothirat, C. Khwannimit, B. Theerawit, P. Pornsuriyasak, P. and Piriyapatsom, A. Mukhtar, A. Dsicu Hamdy, A. Nabil and Hosny, H. Ashraf, A. Mokhtari, M. Nowruzinia, S. Lotfi, A. Zand, F. Nikandish, R. Moghaddam, O. Moradi Cohen, J. and Sold, O. Sfeir, T. Hasan, A. Abugaber, D. Ahmad, H. and Tantawy, T. Baharoom, S. Algethamy, H. Amr, A. and Almekhlafi, G. Coskun, R. Sungur, M. Cosar, A. and Gucyetmez, B. Demirkiran, O. Senturk, E. Ulusoy, H. and Atalan, H. Serin, S. Kati, I Alnassrawi, Z. Almemari, A. and Krishnareddy, K. Kashef, S. Alsabbah, A. Poirier, G. and Marshall, J. Herridge, M. Herridge, M. Fernandez-Medero, R. and Fulda, G. Banschbach, S. Quintero, J. Schroeder, E. and Sicoutris, C. Gueret, R. Kashyap, R. Bauer, P. Nanchal, R. Wunderink, R. Jimenez, E. Ryan, A. Prince, D. and Edington, J. Van Haren, F. Bersten, A. Hawkins, D. J. and Kilminster, M. Sturgess, D. Ziegenfuss, M. O'Connor, S. and Lipman, J. Campbell, L. Mcallister, R. Roberts, B. and Williams, P. Parke, R. Seigne, P. Freebairn, R. Nistor, D. Oxley, C. Young, P. Valentini, R. Wainsztein, N. and Comignani, P. Casaretto, M. Sutton, G. Villegas, P. and Galletti, C. Neira, J. Rovira, D. Hidalgo, J. Sandi, F. and Caser, E. Thompson, M. D'agostino Dias, M. Fontes, L. and Lunardi, M. Youssef, N. Lobo, S. Silva, R. Sales Jr, J. Madeira Campos Melo, L. Oliveira, M. Fonte, M. Grion, C. Feijo, C. Rezende, V Assuncao, M. Neves, A. and Gusman, P. Dalcomune, D. Teixeira, C. Kaefer, K. Maia, I and Souza Dantas, V Costa Filho, R. Amorim, F. Assef, M. and Schiavetto, P. Houly, J. Bianchi, F. Dias, F. Avila, C. and Gomez, J. Rego, L. Castro, P. Passos, J. Mendes, C. and Grion, C. Colozza Mecatti, G. Ferrreira, M. Irineu, V and Guerreiro, M. Ugarte, S. Tomicic, V Godoy, C. and Samaniego, W. Escamilla, I Castro Castro, L. Libreros Duque, G. Diaz-Guio, D. Benitez, F. Guerra Urrego, A. Buitrago, R. Ortiz, G. Villalba Gaviria, M. Salas, D. and Ramirez-Arce, J. Salgado, E. Morocho, D. Vergara, J. and Chung Sang, M. Orellana-Jimenez, C. Garrido, L. Diaz, O. and Resiere, D. Osorio, C. De La Vega, A. Carrillo, R. and Sanchez, V Villagomez, A. Martinez Zubieta, R. Sandia, M. and Zalatiel, M. Poblano, M. Rodriguez Gonzalez, D. and Arrazola, F. Juan Francisco, L. Liamendys-Silva, S. A. and Hernandez, M. Rodriguez Cadena, D. Lopez Islas, I. and Ballesteros Zarzavilla, C. Matos, A. Oyanguren, I Cerna, J. and Quispe Sierra, R. Jimenez, R. Castillo, L. Ocal, R. and Sencan, A. Gianoni, S. Mareque Deicas, A. Hurtado, J. and Burghi, G. Martinelli, A. Von der Osten, I Du Maine, C. and Bhattacharyya, M. Bandyopadhyay, S. Yanamala, S. Gopal, P. and Sahu, S. Ibrahim, M. Rathod, D. Mukundan, N. Dewan, A. Amin, P. Samavedam, S. Shah, B. Gurupal, D. and Lahkar, B. Mandal, A. Sircar, M. Ghosh, S. and Balasubramani, V Kapadia, F. Vadi, S. Nair, K. Tripathy, S. Nandakumar, S. Sharma, J. Kar, A. Jha, S. Gurav, K. Zirpe Patel, M. Bhaysar, A. Samaddar, D. Kulkarni, A. and Hashmi, M. Ali, W. Nadeem, S. Indraratna, K. and Margarit, A. Urbanek, P. Schlieber, J. Reisinger, J. and Auer, U. Hartjes, A. Lerche, A. Janous, T. Kink, E. and Krahulec, W. Smolle, K. Van der Schueren, M. Thibo, P. and Vanhoof, M. Ahmet, I Gadisseux, P. Dufaye, P. Jacobs, O. and Fraipont, V Biston, P. Dive, A. Bouckaert, Y. and Gilbert, E. Gressens, B. Pinck, E. Collin, V Vincent, J. L. De Waele, J. Rimachi, R. Gusu, D. De Decker, K. and Mandianga, K. Heytens, L. Wittebole, X. Spapen, H. and Olivier, V Vandenheede, W. Rogiers, P. Kolodzeike, P. and Kruse, M. Andersen, T. Harjola, V Saarinen, K. Leone, M. and Durocher, A. Moulront, S. Lepape, A. Losser, M. and Cabaret, P. Kalaitzis, E. Zogheib, E. Charve, P. and Francois, B. Lefrant, J. Y. Beilouny, B. Forceville, X. and Misset, B. Jacobs, F. Floccard, B. Payen, D. Wynckel, A. and Castelain, V Faure, A. Lavagne, P. Thierry, I and Moussa, M. Vieillard-Baron, A. Durand, M. Gainnier, M. and Ichai, C. Arens, S. Hoffmann, C. Kaffarnik, M. and Scharnofske, C. Voigt, I Peckelsen, C. Weber, M. Gille, J. Lange, A. Schoser, G. Sablotzki, A. Jaschinski, U. and Bluethgen, A. Vogel, F. Tscheu, A. Fuchs, T. and Wattenberg, M. Helmes, T. Scieszka, S. Heintz, M. Sakka, S. Kohler, J. Fiedler, F. Danz, M. Sakr, Y. Riessen, R. Kerz, T. Kersten, A. Tacke, F. Marx, G. Volkert, T. Schmutz, A. Nierhaus, A. Kluge, S. Abel, P. and Janosi, R. Utzolino, S. Bracht, H. Toussaint, S. and Peftoulidou, M. Giannakou Myrianthefs, P. Armaganidis, A. and Routsi, C. Xini, A. Mouloudi, E. Kokoris, I and Kyriazopoulos, G. Vlachos, S. Lavrentieva, A. Partala, P. and Nakos, G. Moller, A. Stefansson, S. Barry, J. and O'Leary, R. Motherway, C. Faheem, M. Dunne, E. Donnelly, M. Konrad, T. Bonora, E. Achilli, C. Rossi, S. and Castiglione, G. Penis, A. Albanese, D. Stocchetti, N. and Citerio, G. Mozzoni, L. Sisillo, E. De Negri, P. and Savioli, M. Vecchiarelli, P. Puflea, F. Stankovic, V and Minoja, G. Montibeller, S. Calligaro, P. Sorrentino, R. and Feri, M. Zambon, M. Colombaroli, E. Giarratano, A. and Pellis, T. Capra, C. Antonelli, M. Gullo, A. Chelazzi, C. De Capraris, A. Patroniti, N. Girardis, M. Franchi, F. Berlot, G. Buttigieg, M. Ponssen, H. Cate, J. Ten and Bormans, L. Husada, S. Buise, M. Van Der Hoven, B. and Reidinga, A. Kuiper, M. Pickkers, P. Kluge, G. Den Boer, S. Kesecioglu, J. Van Leeuwen, H. Flaatten, H. Mo, S. and Branco, V Rua, F. Lafuente, E. Sousa, M. Catorze, N. and Barros, M. Pereira, L. De Oliveira, A. Vintern Gomes, J. and Gaspar, I Pereira, M. Cymbron, M. Dias, A. Almeida, E. Beirao, S. Serra, I Ribeiro, R. Povoa, P. Faria, F. Costa-E-Silva, Z. Nobrega, A. Fernandes, F. Gabriel, J. Voga, G. Rupnik, E. Kosec, L. Povsic, M. Kerin and Osojnik, I Tomic, V Sinkovic, A. Gonzalez, J. Zavala, E. and Perez Valenzuela, A. Marina, L. Vidal-Cortes, P. Posada, I Ignacio Martin-Loeches, A. Munoz Guillen, N. Palomar, M. and Sole-Violan, U. Torres, A. Gonzalez Gallego, M. Aguilar, G. Montoiro Allue, R. Argueso, M. Parejo, M. Palomo Navarro, M. Jose, A. Nin, N. Alvarez Lerma, F. Martinez, O. Tenza Lozano, E. Arenal Lopez, S. Perez Granda, M. and Moreno, S. Llubia, C. De la Fuente Martos, C. and Gonzalez-Arenas, P. Llamas Fernandez, N. Gil Rueda, B. and Estruch Pons, I Cruza, N. Maroto, F. Estella, A. Ferrer, A. Iglesias Fraile, L. Quindos, B. Quintano, A. Tebar, M. Cardinal, I Reyes, A. Rodriguez, A. Abella, A. and Garcia Del Valle, S. Yus, S. Maseda, E. Berezo, U. and Tejero Pedregosa, A. Laplaza, C. Ferrer, R. Rico-Feijoo, U. and Rodriguez, M. Monedero, P. Eriksson, K. Lind, D. and Chabanel, D. Zender, H. Heer, K. Frankenberger, B. and Jakob, S. Mathew, S. Downes, R. Groba, C. Barrera and Johnston, A. Meacher, R. Keays, R. Haji-Michael, P. and Tyler, C. Ferguson, A. Jones, S. Tyl, D. Ball, A. and Vogel, U. Booth, M. Downie, P. Watters, M. Brett, S. and Garfield, M. Everett, L. Heenen, S. Dhir, S. Beardow, Z. and Mostert, M. Brosnan, S. Pinto, N. Harris, S. and Summors, A. Andrew, N. Rose, A. Appelboam, R. Davies, O. and Vickers, E. Agarwal, B. Szakmany, T. Wimbush, S. and Welters, I Pearse, R. Hollands, R. Kirk-Bayley, U. and Fletcher, N. Bray, B. Brealey, D. ICON Investigators
- Abstract
Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world. Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ( >16 years ) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - 80 years. Sepsis was defined as infection plus at least one organ failure. Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients 70 years was independently associated with increased risk of dying. Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved.
- Published
- 2019
11. age: Observational data from the ICON audit
- Author
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Kotfis, K, Wittebole, X, Jaschinski, U, Sole-Violan, J, Kashyap, R, Leone, M, Nanchal, R, Fontes, LE, Sakr, Y, Vincent, JL, Tomas, E, Bibonge, EA, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, A, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Zbaganu, GV, Slavcovici, A, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, U, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Lee, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Nishida, O, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, NN, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Dsicu, Hamdy, AN, Hosny, H, Ashraf, A, Mokhtari, M, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, OM, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Almekhlafi, G, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Marshall, J, Herridge, M, Fernandez-Medero, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Bauer, P, Wunderink, R, Jimenez, E, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Hawkins, DJ, Kilminster, M, Sturgess, D, Ziegenfuss, M, O'Connor, S, Lipman, J, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, Dias, MD, Fontes, L, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, LMC, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, VS, Filho, RC, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Gomez, J, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, GC, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro, LC, Duque, GL, Diaz-Guio, D, Benitez, F, Urrego, AG, Buitrago, R, Ortiz, G, Gaviria, MV, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, MC, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, RM, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, DR, Arrazola, F, Francisco, LJ, Liamendys-Silva, SA, Hernandez, M, Cadena, DR, Islas, IL, Zarzavilla, CB, Matos, A, Oyanguren, I, Cerna, J, Sierra, RQ, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Gianoni, SM, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, D, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Gurav, KZ, Patel, M, Bhaysar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, U, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Spapen, H, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, JY, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, I, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, 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H, Heer, K, Frankenberger, B, Jakob, S, Mathew, S, Downes, R, Groba, CB, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, U, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, U, Fletcher, N, Bray, B, and Brealey, D
- Abstract
Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world. Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ( >16 years ) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - 80 years. Sepsis was defined as infection plus at least one organ failure. Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients 70 years was independently associated with increased risk of dying. Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved. C1 [Kotfis, Katarzyna] Pomeranian Med Univ, Dept Anaesthesiol Intens Therapy & Acute Intoxica, Szczecin, Poland. [Wittebole, Xavier] UCL, Clin Univ St Luc, Dept Crit Care, Brussels, Belgium. [Jaschinski, Ulrich] Klinikum Augsburg, Klin Anasthesiol & Operat Intens Med, Augsburg, Germany. [Sole-Violan, Jordi] Hosp Univ Gran Canaria Dr Negrin, Dept Intens Care, Las Palmas Gran Canaria, Spain. [Kashyap, Rahul] Mayo Clin, Dept Anesthesia Ei Perioperat Med, Rochester, MN USA. [Leone, Marc] Aix Marseille Univ, Hop Nord, AP HM, Serv Anesthesie & Reanimat, Marseille, France. [Nanchal, Rahul] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA. [Fontes, Luis E.] Hosp Alcides Carneiro, Petropolis Med Sch, Dept Intens Care & Evidence Based Med, Petropolis, Brazil. [Sakr, Yasser] Uniklinikum Jena, Dept Anesthesiol & Intens Care, Jena, Germany. [Vincent, Jean-Louis] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Intens Care, Route Lenn 808, B-1070 Brussels, Belgium. [Tomas, E.] Clin Sagrada Esperanca, Luanda, Angola. [Bibonge, E. Amisi] Clin Univ Kinshasa, Kinshasa, DEM REP CONGO. [Charra, B.] Chu Ibn Rochd Casablanca, Casablanca, Morocco. [Faroudy, M.] Ibn Sina Hosp, Rabat, Morocco. [Doedens, L.] Chris Hani Baragwanath Acad Hosp, Soweto, South Africa. [Farina, Z.] Grays Hosp, Pietermaritzburg, South Africa. [Adler, D.] Sandton Medi Clin, Sandton, South Africa. [Balkema, C.] Tygerberg Hosp, Cape Town, South Africa. [Kok, A.] Union Hosp Alberton, Alberton, South Africa. [Alaya, S.] Bizerte Hosp, Bizerte, Tunisia. [Gharsallah, H.] Mil Hosp Tunis, Tunis, Tunisia. [Muzha, D.] Natl Trauma Ctr & Mil Hosp, Tirana, Albania. [Temelkov, A.] Alexandrovska Univ Hosp, Sofia, Bulgaria. [Georgiev, G.] Emergency Univ Hosp Pirogov, Sofia, Bulgaria. 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[Jiang, W.] Shanghai 10th Peoples Hosp, Shanghai, Peoples R China. [Ruilan, W.] Shanghai First Peoples Hosp, Shanghai, Peoples R China. [Chen, Y.; Xiaobo, H.] Sichuan Prov Peoples Hosp, Chengdu, Sichuan, Peoples R China. [Ge, H.] Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China. [Yan, T.] Affiliated Guiyang Med Coll, Guiyang, Guizhou, Peoples R China. [Yuhui, C.] Fudan Univ, Peoples Hosp Shanghai 5, Shanghai, Peoples R China. [Zhang, J.] Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China. [Jian-Hong, F.] Suzhou Univ, Affiliated Hosp 1, Suzhou, Peoples R China. [Zhu, H.] Xinjiang Med Univ, Affiliated Hosp 1, Urumqi, Peoples R China. [Huo, F.; Wang, Y.] Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China. [Li, C.] First Peoples Hosp Kunming, Kunming, Yunnan, Peoples R China. [Zhuang, M.] Gen Hosp Shenyang Mil Reg, Shenyang, Liaoning, Peoples R China. [Ma, Z.] Peoples Hosp Cangzhou, Cangzhou, Peoples R China. [Sun, J.] Jilin Univ, Hosp 2, Changchun, Jilin, Peoples R China. [Liuqingyue, L.] Second Peoples Hosp Liaocheng City Shandong Prov, Liaocheng, Shandong, Peoples R China. [Yang, M.] Third Xiangya Hosp, Changsha, Hunan, Peoples R China. [Meng, J.] Tongde Hosp Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China. [Ma, S.] Tongji Univ, Shanghai East Hosp, Shanghai, Peoples R China. [Kang, Y.] West China Hosp, Scu, Peoples R China. [Yu, L.] Wuhan Ctr Hosp, Wuhan, Hubei, Peoples R China. [Peng, Q.] Xiangya Hosp, Changsha, Hunan, Peoples R China. [Wei, Y.] Yantai Yuhuangding Hosp, Yantai, Peoples R China. [Zhang, W.] Yantaishan Hosp, Yantai, Shandong, Peoples R China. [Sun, R.] Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China. [Yeung, A.] Pamela Youde Nethersole Eastern Hosp, Hong Kong, Peoples R China. [Wan, W.] Princess Margaret Hosp, Hong Kong, Peoples R China. [Sin, K.] Queen Elizabeth Hosp, Hong Kong, Peoples R China. [Lee, K.] United Christian Hosp Hong Kong SAR, Hong Kong, Peoples R China. [Wijanti, M.] Anestesi, Yogyakarta, Indonesia. [Widodo, U.] Pku Muhammadiyah Bantu, Yogyakarta, Indonesia. [Samsirun, H.] Rd Mattaher Hosp Jambi, Jambi City, Indonesia. [Sugiman, T.] Rumah Sakit Pantai Lndah Kapuk, North Jakarta, Indonesia. [Wisudarti, C.] Sardjito Hosp, Yogyakarta, Indonesia. [Maskoen, T.] Sch Med Unpad, Hasan Sadikin Hosp, Bandung, Indonesia. [Hata, N.] Nippon Med Sch, Chiba Hokusoh Hosp, Inzai, Japan. [Kobe, Y.] Chiba Univ Hosp, Chiba, Japan. [Nishida, O.] Fujita Hlth Univ, Sch Med, Toyoake, Aichi, Japan. [Miyazaki, D.] Japanese Red Cross Maebashi Hosp, Maebashi, Gumma, Japan. [Nunomiya, S.] Jichi Med Univ Hosp, Shimotsuke, Japan. [Uchino, S.] Jikei Univ, Sch Med, Tokyo, Japan. [Kitamura, N.] Kimitsu Chuo Hosp, Kisarazu, Japan. [Yamashita, K.] Kochi Med Sch, Nankoku, Kochi, Japan. [Hashimoto, S.] Kyoto Prefectural Univ Med, Kyoto, Japan. [Fukushima, H.] Nara Med Univ Hosp, Kashihara, Nara, Japan. [Adib, N. Nik] Hosp Sultanah Nur Zahirah, Kuala Terengganu, Terengganu, Malaysia. [Tai, L.] Kuala Lumpur Hosp, Kuala Lumpur, Malaysia. [Tony, B.] Queen Elizabeth Hosp 2, Kota Kinabalu, Malaysia. [Bigornia, R.] Cebu Velez Gen Hosp, Cebu, Philippines. [Bigornia, R.] Perpetual Succour Hosp, Cebu, Philippines. [Palo, J.] Med City, Pasig, Philippines. [Chatterjee, S.] Alexandra Hosp, Singapore, Singapore. [Tan, B.] Natl Univ Hlth Syst, Singapore, Singapore. [Kong, A.] Singapore Gen Hosp, Singapore, Singapore. [Goh, S.] Tan Tock Seng Hosp, Singapore, Singapore. [Lee, C.] Natl Taiwan Univ Hosp, Taipei, Taiwan. [Pothirat, C.] Chiaingmai Univ, Maharaj Nakorn Chiangmai Hosp, Chiang Mai, Thailand. [Khwannimit, B.] Prince Songkla Univ, Hat Yai, Thailand. [Theerawit, P.] Ramathibodi Hosp, Bangkok, Thailand. [Pornsuriyasak, P.] Ramathibodi Hosp, Somdech Phra Debaratana Med Ctr, Bangkok, Thailand. [Piriyapatsom, A.] Mahidol Univ, Siriraj Hosp, Bangkok, Thailand. [Mukhtar, A.] Cairo Univ, Giza, Egypt. [Dsicu] Demerdash Surg Intens Care Unit, Cairo, Egypt. [Hamdy, A. Nabil] Ain Shams Fac Med, Cairo, Egypt. [Hosny, H.] Zaitoun Specialized Hosp, Cairo, Egypt. [Ashraf, A.] Gums, Tehran, Iran. [Mokhtari, M.] Sbums, Imam Hossein Hosp, Tehran, Iran. [Nowruzinia, S.] Imamreza Hosp, Mashhad, Razavi Khorasan, Iran. [Lotfi, A.] Laleh Hosp, Tehran, Iran. [Zand, F.] Shiraz Anesthesiol & Crit Care Res Ctr, Shiraz, Iran. [Nikandish, R.] Shiraz Univ Med Sci, Shiraz, Iran. [Moghaddam, O. Moradi] Tehran Med Sci Univ, Tehran, Iran. [Cohen, J.] Rabin Med Ctr, Petah Tiqwa, Israel. [Sold, O.] Sourasky Tel Aviv Med Ctr, Tel Aviv, Israel. [Sfeir, T.] Ctr Hosp Nord, Ettelbruck, Luxembourg. [Hasan, A.] Sohar Hosp, Sohar, Oman. [Abugaber, D.] Specialized Arab Hosp, Nablus, Palestine. [Ahmad, H.] Almana Gen Hosp, Khobar, Saudi Arabia. [Tantawy, T.] KFSHRC, Riyadh, Saudi Arabia. [Baharoom, S.] King Abdulaziz Med City Riyadh, Riyadh, Saudi Arabia. [Algethamy, H.] King Abdulaziz Univ, Jeddah, Saudi Arabia. [Amr, A.] King Saud Med City, Riyadh, Saudi Arabia. [Almekhlafi, G.] Riyadh Mil Hosp, Riyadh, Saudi Arabia. [Coskun, R.] Erciyes Univ, Med Fac, Kayseri, Turkey. [Sungur, M.] Erciyes Univ, Med Sch, Kayseri, Turkey. [Cosar, A.] Gulhane Mil Med Acad, Ankara, Turkey. [Gucyetmez, B.] Int Hosp, Istanbul, Turkey. [Demirkiran, O.] Istanbul Univ, Cerrahpasa Med Sch Hosp, Istanbul, Turkey. [Senturk, E.] Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey. [Ulusoy, H.] Karadeniz Tech Univ, Med Fac, Trabzon, Turkey. [Atalan, H.] Mem Atasehir Hosp, Istanbul, Turkey. [Serin, S.] Pamukkale Univ, Denizli, Turkey. [Kati, I] Yuzuncu Yil Univ, Med Fac, Van, Turkey. [Alnassrawi, Z.] Dubai Hosp, Dubai, U Arab Emirates. [Almemari, A.] Mafraq Hosp, Abu Dhabi, U Arab Emirates. [Krishnareddy, K.] Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates. [Kashef, S.] Tawam Hosp, Al Ain, U Arab Emirates. [Alsabbah, A.] City Hosp, Dubai, U Arab Emirates. [Poirier, G.] Hop Charles Lemoyne, Longueuil, PQ, Canada. [Marshall, J.] St Michaels Hosp, Toronto, ON, Canada. [Herridge, M.] Toronto Gen Hosp, Toronto, ON, Canada. [Herridge, M.] Toronto Western Hosp, Toronto, ON, Canada. [Fernandez-Medero, R.] San Juan Hosp, San Juan, PR USA. [Fulda, G.] Christiana Care Hlth Syst, Newark, DE USA. [Banschbach, S.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Quintero, J.] El Camino Hosp, Mountain View, CA USA. [Schroeder, E.] George Washington Hosp, Washington, DC USA. [Sicoutris, C.] Hosp Univ Penn, Philadelphia, PA 19104 USA. [Gueret, R.] John H Stroger Hosp Cook Cty, Chicago, IL USA. [Kashyap, R.] Mayo Clin, CCM, Rochester, MN USA. [Bauer, P.] Mayo Clin, PCC, Rochester, MN USA. [Nanchal, R.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Wunderink, R.] Northwestern Mem Hosp, Chicago, IL 60611 USA. [Jimenez, E.] Orlando Reg Med Ctr Inc, Orlando, FL USA. [Ryan, A.] Washington Hosp Ctr, Washington, DC 20010 USA. [Ryan, A.] Washington Hosp Ctr, 2H, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, 2G, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, 3H, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, 3G, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, 4H, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, CVRR, Washington, DC USA. [Prince, D.] Armadale Hlth Serv, Mount Nasura, WA, Australia. [Edington, J.] Bendigo Hosp, Bendigo, Vic, Australia. [Van Haren, F.] Canberra Hosp, Canberra, ACT, Australia. [Bersten, A.] Flinders Med Ctr, Bedford Pk, SA, Australia. [Hawkins, D. J.] Joondalup Hlth Campus, Joondalup, WA, Australia. [Kilminster, M.] Lismore Base Hosp, Lismore, NSW, Australia. [Sturgess, D.] Mater Adult Hosp, South Brisbane, Qld, Australia. [Ziegenfuss, M.] Prince Charles Hosp, Brisbane, Qld, Australia. [O'Connor, S.] Royal Adelaide Hosp, Adelaide, SA, Australia. [Lipman, J.] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia. [Campbell, L.] Royal Darwin Hosp, Tiwi, NT, Australia. [Mcallister, R.] Royal Hobart Hosp, Hobart, Tas, Australia. [Roberts, B.] Sir Charles Gairdner Hosp, Nedlands, WA, Australia. [Williams, P.] Queen Elizabeth Hosp, Woodville, SA, Australia. [Parke, R.] Auckland Dist Hlth Board, Auckland, New Zealand. [Seigne, P.] Christchurch Hosp, Christchurch, New Zealand. [Freebairn, R.] Hawkes Bay Hosp, Hastings, New Zealand. [Nistor, D.] Palmerston North Hosp, Midcent Hlth, Palmerston North, New Zealand. [Oxley, C.] Middlemore Hosp, Auckland, New Zealand. [Young, P.] Wellington Hosp, Wellington, New Zealand. [Valentini, R.] Cemic, Buenos Aires, DF, Argentina. [Wainsztein, N.] Fleni, Buenos Aires, DF, Argentina. [Comignani, P.] Hosp Aleman, Buenos Aires, DF, Argentina. [Casaretto, M.] Hosp Cent San Isidro, Buenos Aires, DF, Argentina. [Sutton, G.] Hosp Fernandez, Buenos Aires, DF, Argentina. [Villegas, P.] Hosp Francisco Lopez Lima Area Programa Gen Roca, Gen Roca, Argentina. [Galletti, C.] Sanatorio Allende, Cordoba, Argentina. [Neira, J.] Sanatorio Trinidad Palermo, Buenos Aires, DF, Argentina. [Rovira, D.] Sanatorio Julio Corzo Rosario, Rosario, Santa Fe, Argentina. [Hidalgo, J.] Karl Heusner Mem Hosp, Belize City, Belize. [Hidalgo, J.] Belize Healthcare Partner, Belize City, Belize. [Sandi, F.] Hosp Obrero 1, La Paz, Bolivia. [Caser, E.] Cias Unimed Vitoria, Vitoria, ES, Brazil. [Thompson, M.] Evangelical Hosp Cachoeiro De Itapemirim, Cachoeiro De Itapemirim, Brazil. [D'agostino Dias, M.] Hosp 9 Julho, Sao Paulo, Brazil. [Fontes, L.] Hosp Alcides Carneiro, Petropolis, Brazil. [Lunardi, M.] Hosp Clin Luzia De Pinho Melo, Mogi Das Cruzes, Brazil. [Youssef, N.] Hosp Nacoes Curitiba, Curitiba, Parana, Brazil. [Lobo, S.] Hosp Base Famerp, Sao Jose Do Rio Preto, Brazil. [Silva, R.] Hosp Clin Niteroi, Niteroi, RJ, Brazil. [Sales Jr, J.] Hosp Clin Padre Miguel, Rio De Janeiro, Brazil. [Madeira Campos Melo, L.] Hosp Terapia Intens, Sao Paulo, Brazil. [Oliveira, M.] Hosp Trabalhador, Curitiba, Parana, Brazil. [Fonte, M.] Hosp Esperanza, Olinda, PE, Brazil. [Grion, C.] Hosp Evangel Londrina, Londrina, Brazil. [Feijo, C.] Hosp Geral Fortaleza, Fortaleza, Ceara, Brazil. [Rezende, V] Hosp Geral Roraima, Boa Vista, Brazil. [Assuncao, M.] Hosp Israelita Albert Einstein, Sao Paulo, Brazil. [Neves, A.] Hosp Mater Dei, Belo Horizonte, MG, Brazil. [Gusman, P.; Dalcomune, D.] Hosp Meridional, Cariacica, ES, Brazil. [Teixeira, C.] Hosp Moinhos Vento, Porto Alegre, RS, Brazil. [Kaefer, K.] Hosp Municipal Ruth Cardoso, Balneario, Brazil. [Maia, I] Hosp Nereu Ramos, Florianopolis, SC, Brazil. [Souza Dantas, V] Hosp Pasteur, Rio De Janeiro, Brazil. [Costa Filho, R.] Hosp Pro Cardiaco, Rio De Janeiro, Brazil. [Amorim, F.] Hosp Reg Samambaia, Brasilia, DF, Brazil. [Assef, M.] Hosp Reg Hans Dieter Schmidt, Joinville, Brazil. [Schiavetto, P.] Hosp Santa Casa Campo Mourao, Campo Mourao, PR, Brazil. [Houly, J.] Hosp Santa Paula, Sao Paulo, SP, Brazil. [Houly, J.] Hosp Santapaula, Sao Paulo, Brazil. [Bianchi, F.] Hosp Sao Jose Avai, Itaperuna, RJ, Brazil. [Dias, F.] Hosp Sao Lucas Pucrs, Porto Alegre, RS, Brazil. [Avila, C.] Hosp Sao Vicente Paula, Rio De Janeiro, RJ, Brazil. [Gomez, J.] Hosp Sao Vicente Paulo, Rio De Janeiro, Brazil. [Rego, L.] Hosp Saude Mulher, Belem, Para, Brazil. [Castro, P.] Hosp Tacchini, Bento Goncalves, RS, Brazil. [Passos, J.] Hosp Unimed Costa Do Sol Macae Rj, Macae, RJ, Brazil. [Mendes, C.] Hosp Univ Ufpb Joao Pessoa, Joao Pessoa, Paraiba, Brazil. [Grion, C.] Hosp Univ Londrina, Londrina, Brazil. [Colozza Mecatti, G.] Hosp Univ Sao Francisco, Braganca Paulista, SP, Brazil. [Ferrreira, M.] Santa Casa Caridade Diamantina, Diamantina, MG, Brazil. [Irineu, V] Santa Casa Misericordia Tatui, Tatui, Brazil. [Guerreiro, M.] Sao Francisco de Paula Hosp, Sao Francisco De Paula, RS, Brazil. [Ugarte, S.] Clin Indisa, Providencia, Chile. [Tomicic, V] Clin Las Lilas, Providencia, Chile. [Godoy, C.] Hosp Carlos Van Buren, Valparaiso, Chile. [Samaniego, W.] Hosp Trabajador Santiago, Santiago, Chile. [Escamilla, I] Hosp El Pino, San Bernardo, Chile. [Escamilla, I] Hosp Mutual De Seguridad, Santiago, Chile. [Castro Castro, L.] Ctr Med Imbanaco, Valle Del Cauca, Colombia. [Libreros Duque, G.] Clin Colombia Cali, Cali, Colombia. [Diaz-Guio, D.] Clin Del Cafe, Armenia, Colombia. [Benitez, F.] Clin La Estancia SA, Popayan, Colombia. [Guerra Urrego, A.] Clin Medellin, Medellin, Colombia. [Buitrago, R.] Fdn Clin Shaio, Bogota, Colombia. [Ortiz, G.] Hosp Santa Clara, Bogota, Colombia. [Villalba Gaviria, M.] Hosp Univ Fdn Santa Fe De Bogota, Bogota, Colombia. [Salas, D.] Calderon Guardia Hosp, San Jose, Costa Rica. [Ramirez-Arce, J.] Hosp Dr Rafael Angel Varlderon Guardia Ccss, San Jose, Costa Rica. [Salgado, E.] Clin La Merced, Quito, Ecuador. [Morocho, D.] Hosp Eugenio Espejo, Quito, Ecuador. [Vergara, J.] Hosp Luis Vernaza, Quito, Ecuador. [Chung Sang, M.] Shdug Sistema Hosp Docente De La Univ Guayaquil, Quito, Ecuador. [Orellana-Jimenez, C.] Gen Hosp, San Salvador, El Salvador. [Garrido, L.] Hosp Ctr Med, Guatemala City, Guatemala. [Diaz, O.] Inst Hondureno Seguro Social, La Ceiba, Honduras. [Resiere, D.] Ctr Hosp Univ Ft De France, Fort De France, Martinique, France. [Osorio, C.] Ctr Estatal Cuidados Crit, Salamanca, Mexico. [De La Vega, A.] Ctr Med Nacl 20 Noviembre Issste, Mexico City, DF, Mexico. [Carrillo, R.] Fdn Clin Med Sur, Mexico City, DF, Mexico. [Sanchez, V] Hosp San Jose TEC Monterrey, Monterrey, Mexico. [Villagomez, A.] Hosp 1 Octubre, Issste, Mexico. [Martinez Zubieta, R.] Hosp Espanol Mexico, Mexico City, DF, Mexico. [Sandia, M.] Hosp Gen Ajusco Medio, Mexico City, DF, Mexico. [Zalatiel, M.] Hosp Gen Guadalupe Victoria, Texcoco, Mexico. [Poblano, M.] Hosp Juarez Mexico, Mexico City, DF, Mexico. [Rodriguez Gonzalez, D.] Hosp Civil Guadalajara, Hspitaljuan I Menchaca, Guadalajara, Jalisco, Mexico. [Arrazola, F.; Juan Francisco, L.] Inst Mexicano Seguro Social, Mexico City, DF, Mexico. [Liamendys-Silva, S. A.] Inst Nacl Cancerol, Mexico City, DF, Mexico. [Hernandez, M.] ISSSTE Guerra Moya, Mexico City, DF, Mexico. [Hernandez, M.] Med Ctr ISSEMYM Toluca, Mexico City, DF, Mexico. [Rodriguez Cadena, D.] Mixta, Mexico City, DF, Mexico. [Lopez Islas, I.] Secretaria Salud Dist Fed, Mexico City, DF, Mexico. [Ballesteros Zarzavilla, C.] Hosp Santo Comas, Panama City, Panama. [Matos, A.] Social Secur Hosp, La Chorrera, Panama. [Oyanguren, I] Clin Anglo Amer, Lima, Peru. [Cerna, J.] Essalud, Lima, Peru. [Quispe Sierra, R.] Hosp Nacl Dos De Mayo, Lima, Peru. [Jimenez, R.] Hosp Rebagliati, Lince Dist, Peru. [Castillo, L.] Inst Nacl Enfermedades Neoplas, Surquillo, Peru. [Ocal, R.] Gulhane Med Fac, Istanbul, Turkey. [Sencan, A.] Izmir Ataturk Educ & Res Hosp, Izmir, Turkey. [Gianoni, S. Mareque] CAMS, Montevideo, Uruguay. [Deicas, A.] CASMU, Montevideo, Uruguay. [Hurtado, J.] Hosp Espanol Asse, Montevideo, Uruguay. [Burghi, G.] Hosp Maciel, Montevideo, Uruguay. [Martinelli, A.] Ctr Med Caracas, Caracas, Venezuela. [Von der Osten, I] Hosp Miguel Perez Carreno, Caracas, Venezuela. [Du Maine, C.] MSF Trauma Hosp Kunduz, Kunduz, Afghanistan. [Bhattacharyya, M.] Amri Hosp, Kolkata, India. [Bandyopadhyay, S.] Amri Hosp Salt Lake, Kolkata, W Bengal, India. [Yanamala, S.] Apollo Hosp, Hyderabad, India. [Gopal, P.] Apollo Hosp, Bangalore, Karnataka, India. [Sahu, S.] Apollo Hosp, Bhubaneswar, India. [Ibrahim, M.] Apollo Special Hosp, Chennai, Tamil Nadu, India. [Rathod, D.] Asian Heart Inst, Mumbai, Maharashtra, India. [Mukundan, N.] Baby Mem Hosp Ltd, Calicut, Kerala, India. [Dewan, A.] Batra Hosp & Mrc, New Delhi 110062, India. [Amin, P.] Bombay Hosp Inst Med Sci, Mumbai, Maharashtra, India. [Samavedam, S.] Care Hosp, Hyderabad, India. [Shah, B.] Cims Hosp, Ahmadabad, Gujarat, India. [Gurupal, D.] Columbiaasia Hosp, Mysore, Karnataka, India. [Lahkar, B.] Dispur Hosp, Gauhati, India. [Mandal, A.] Fortis Hosp, Bangalore, Karnataka, India. [Sircar, M.] Fortis Hosp, Noida, India. [Ghosh, S.] Fortis Escorts Hosp, Faridabad, India. [Balasubramani, V] Ganga Med Ctr & Hosp P Ltd, Coimbatore, Tamil Nadu, India. [Kapadia, F.] Hinduja Hosp, Mumbai, Maharashtra, India. [Vadi, S.] KDAH, Mumbai, Maharashtra, India. [Nair, K.] Kerala Inst Med Sci, RMCC, Thiruvananthapuram, Kerala, India. [Tripathy, S.] Kalinga Inst Med Sci, DTEM, Bhubaneswar, Odisha, India. [Nandakumar, S.] Kovai Med Ctr & Hosp, Coimbatore, Tamil Nadu, India. [Sharma, J.] Medanta Medic, Gurgaon, India. [Kar, A.] Med Superspecialty Hosp, Kolkata, W Bengal, India. [Jha, S.] Metro Heart Inst Multispecial, Faridabad, India. [Gurav, K. Zirpe] Ruby Hall Pune, Pune, Maharashtra, India. [Patel, M.] Saifee Hosp, Mumbai, Maharashtra, India. [Bhaysar, A.] Spandan Multispecial Hosp, Vadodara, India. [Samaddar, D.] Tata Main Hosp, Jamshedpur, Jharkhand, India. [Kulkarni, A.] Tata Mem Hosp, Mumbai, Maharashtra, India. [Hashmi, M.] Aga Khan Univ, Karachi, Pakistan. [Ali, W.] Hearts Int Hosp, Rawalpindi, Pakistan. [Nadeem, S.] Liaquat Natl Hosp, Karachi, Pakistan. [Indraratna, K.] Sri Jayewardenepura Gen Hosp, Sri Jayawardenepura Kott, Sri Lanka. [Margarit, A.] Hosp Nostra Senyora Meritxell, Les Escaldes, Andorra. [Urbanek, P.] Akh Wien, Vienna, Austria. [Schlieber, J.] Allgemeines & Orthopad Landeskrankenhaus Stolzalp, Stolzalpe, Austria. [Reisinger, J.] Barmherzige Schwestern Linz, Linz, Austria. [Auer, U.] Gen Hosp Braunau, Braunau, Austria. [Hartjes, A.] Krankenhaus D Barmherzigen Schwestern Ried II, Ried Im Innkreis, Austria. [Lerche, A.] Krankenhaus Floridsdorf, Vienna, Austria. [Janous, T.] LK Gmund Waidhofen Thaya Zwettl, Standort Zwettl, Austria. [Kink, E.] LKH Horgas Enzenbach, Gratwein, Austria. [Krahulec, W.] LKH West, Graz, Austria. [Smolle, K.] Univ Hosp, Graz, Austria. [Van der Schueren, M.] AZ Groeninge Kortrijk, Kortrijk, Belgium. [Thibo, P.] AZ Jan Palfijn Gent, Ghent, Belgium. [Vanhoof, M.] AZ Turnhout, Turnhout, Belgium. [Ahmet, I] Bracops Anderlecht, Anderlecht, Belgium. [Gadisseux, P.] Ctr Hosp Mouscron, Mouscron, Belgium. [Dufaye, P.] CH Peltzer La Tourelle, Verviers, Belgium. [Jacobs, O.] Chirec Edith Cavell, Auderghem, Belgium. [Fraipont, V] CHR Citadelle, Liege, Belgium. [Biston, P.] CHU Charleroi, Charleroi, Belgium. [Dive, A.] CHU Mt Godinne, Yvoir, Belgium. [Bouckaert, Y.] CHU Tivoli, La Louviere, Belgium. [Gilbert, E.] CHwapi, Tournai, Belgium. [Gressens, B.] Clin St Pierre Ottignies, Ottignies, Belgium. [Pinck, E.] Clin Maternite St Elisabeth, Namur, Belgium. [Collin, V] Clin Europe St Michel, Etterbeek, Belgium. [Vincent, J. L.] Erasme Univ Hosp, Anderlecht, Belgium. [De Waele, J.] Ghent Univ Hosp, Ghent, Belgium. [Rimachi, R.] Moliere Hosp, Forest, Belgium. [Gusu, D.] Notre Dame, Brussels, Belgium. [De Decker, K.] Onze Lieve Vrouw Hosp, Aalst, Belgium. [Mandianga, K.] Ixelles Hosp, Ixelles, Belgium. [Heytens, L.] Sint Augustinus, Antwerp, Belgium. [Wittebole, X.] St Luc Univ Hosp UCL, Brussels, Belgium. [Spapen, H.] UZ Brussel, Brussels, Belgium. [Olivier, V] Vivalia Site Libramt, Libramont, Belgium. [Vandenheede, W.] VZW Gezondheidszorg Oostkust Knokke Heist, Knokke Heist, Belgium. [Rogiers, P.] ZNA Middelheim, Antwerp, Belgium. [Kolodzeike, P.] Herning Hosp, Herning, Denmark. [Kruse, M.] Hjoerring Hosp, Hjorring, Denmark. [Andersen, T.] Vejle Hosp, Vejle, Denmark. [Harjola, V] Helsinki Univ Cent Hosp, Helsinki, Finland. [Saarinen, K.] Seinajoki Cent Hosp, Seinajoki, Finland. [Leone, M.] Aix Marseille Univ, Hop Nord, Marseille, France. [Durocher, A.] Calmette Hosp, Lille, France. [Moulront, S.] Ctr Hosp Dunkerque, Dunkerque, France. [Lepape, A.] Ctr Hosp Lyon Sud, Lyon, France. [Losser, M.] CHU Nancy Brabois, Nancy, France. [Cabaret, P.] CH St Philibert, GHICL, Lille, France. [Kalaitzis, E.] CHR Dax, Dax, France. [Zogheib, E.] CHU Amiens, Amiens, France. [Charve, P.] CHU Dijon, Dijon, France. [Francois, B.] CHU Dupuytren, Limoges, France. [Lefrant, J. Y.] CHU Nimes, Nimes, France. [Beilouny, B.] Ctr Hosp Troyes, Troyes, France. [Forceville, X.] Ctr Hosp Meaux, Grp Hosp Est Francilien, Meaux, France. [Misset, B.] Grp Hosp Paris St Joseph, Paris, France. [Jacobs, F.] Hop Antoine Beclere, Clamart, France. [Floccard, B.] Hop Edouard Herriot, Lyon, France. [Payen, D.] Hop Lariboisere, AP HP, Paris, France. [Wynckel, A.] Hop Maison Blanche, Reims, France. [Castelain, V] Hop Univ Strasbourg, Strasbourg, France. [Faure, A.] Hosp Civils Lyon, Lyon, France. [Lavagne, P.] CHU Grenoble, Grenoble, France. [Thierry, I] CHU Nantes, Nantes, France. [Moussa, M.] CHRU Lille, Reanimat Chirurg Cardiovasc, Lille, France. [Vieillard-Baron, A.] Univ Hosp Ambroise Pare, Boulogne, France. [Durand, M.] Univ Hosp Grenoble, La Tronche, France. [Gainnier, M.] Univ Hosp Marseille, Marseille, France. [Ichai, C.] Univ Nice, Nice, France. [Arens, S.] Alexianer Krefeld Gmbh, Krefeld, Germany. [Hoffmann, C.] Charite Hochschulmed Berlin, Berlin, Germany. [Kaffarnik, M.] Charite, Berlin, Germany. [Scharnofske, C.] Diakoniekrankenhaus Henriettenstiftung Gmbh, Hannover, Germany. [Voigt, I] Elisabeth Krankenhaus Essen, Essen, Germany. [Peckelsen, C.] Munich Municipal Hosp Grp, Harlaching Hosp, Munich, Germany. [Weber, M.] Helios St Johannes Klin, Duisburg, Germany. [Gille, J.] Hosp St Georg Leipzig, Leipzig, Germany. [Lange, A.] Klin Hennigsdorf Oberhavel Kliniken Gmbh, Hennigsdorf, Germany. [Schoser, G.] Klin Tettnang, Tettnang, Germany. [Sablotzki, A.] Klinikum St Georg Leipzig, Leipzig, Germany. [Jaschinski, U.; Bluethgen, A.] Klinikum Augsburg, Augsburg, Germany. [Vogel, F.] Klinikum Bremen Mitte, Bremen, Germany. [Tscheu, A.] Klinikum Bremen Ost, Bremen, Germany. [Fuchs, T.] Klinikum Heidenheim, Heidenheim, Germany. [Wattenberg, M.] Klinikum Links Weser Gmbh, Bremen, Germany. [Helmes, T.] Klinikum Luedenscheid, Luedenscheid, Germany. [Scieszka, S.] Krankenhaus Neuwerk, Monchengladbach, Germany. [Heintz, M.] Marienkrankenhaus Schwerte, Schwerte, Germany. [Sakka, S.] Med Ctr Cologne Merheim, Cologne, Germany. [Kohler, J.] Schwarzwald Baar Klinikum Villingen Schwenningen, Villingen Schwenningen, Germany. [Fiedler, F.] St Elisabeth Krankenhaus Koln Hohenlind, Cologne, Germany. [Danz, M.] St Martinus Hosp Olpe, Olpe, Germany. [Sakr, Y.] Uniklinikum Jena, Jena, Germany. [Riessen, R.] Univ Klinikum Tubingen, Tubingen, Germany. [Kerz, T.] Univ Med Mainz, Mainz, Germany. [Kersten, A.] Univ Hosp Aachen, CPACC, Aachen, Germany. [Tacke, F.] Univ Hosp Aachen, DMIII, Aachen, Germany. [Marx, G.] Univ Hosp Aachen, OIC, Aachen, Germany. [Volkert, T.] Univ Hosp Muenster, Munster, Germany. [Schmutz, A.] Univ Med Ctr Freiburg, Freiburg, Germany. [Nierhaus, A.; Kluge, S.] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany. [Abel, P.] Univ Med Greifswald, Greifswald, Germany. [Janosi, R.] Univ Duisburg Essen, Essen, Germany. [Utzolino, S.] Univ Freiburg, Freiburg, Germany. [Bracht, H.] Univ Clin Ulm, Ulm, Germany. [Toussaint, S.] Vivantes Klinikum Neukoelln, Berlin, Germany. [Peftoulidou, M. Giannakou] Ahepa Univ Hosp, Thessaloniki, Greece. [Myrianthefs, P.] Univ Athens, Athens, Greece. [Armaganidis, A.] Univ Athens, Med Sch, Athens, Greece. [Routsi, C.] Evangelismos Med Ctr, Athens, Greece. [Xini, A.] Gen Hosp Chania, Iraklion, Greece. [Mouloudi, E.] Hippokrateion Hosp, Thessaloniki, Greece. [Kokoris, I] Gen Hosp Velos, Volos, Greece. [Kyriazopoulos, G.] Lamia Gen Hosp, Lamia, Greece. [Vlachos, S.] Naval & Vet Hosp, Athens, Greece. [Lavrentieva, A.] Apanikolaou Gen Hosp, Thessaloniki, Greece. [Partala, P.] Univ Hosp Alexandroupolis, Alexandroupolis, Greece. [Nakos, G.] Univ Ioannina, Ioannina, Greece. [Moller, A.] Landspitali Univ Hosp, Reykjavik, Iceland. [Stefansson, S.] Landspitali Univ Hosp Fossvogur, Reykjavik, Iceland. [Barry, J.] Cork Univ Hosp, Cork, Ireland. [O'Leary, R.] Mercy Univ Hosp, Cork, Ireland. [Motherway, C.] Mid Western Reg Hosp Complex, Limerick, Ireland. [Faheem, M.] Midland Reg Hosp Mullingar, Mullingar, Co Westmeath, Ireland. [Dunne, E.] St Vincents Univ Hosp, Dublin, Ireland. [Donnelly, M.] Tallaght Hosp, Dublin, Ireland. [Konrad, T.] Univ Hosp Galway, Galway, Ireland. [Bonora, E.] Anesthesiol & Intens Care, Milan, Italy. [Achilli, C.] AO Osped Niguarda Ca Granda, Milan, Italy. [Rossi, S.] Azienda Osped Padova, Padua, Italy. [Castiglione, G.] Azienda Ospedaliero Univ Policlin Vittorio Emanue, Catania, Italy. [Penis, A.] Careggi Teaching Hosp, Florence, Italy. [Albanese, D.] Clinicized Hosp Ss Annunziata Chieti, Chieti, Italy. [Stocchetti, N.] Fdn Irccs Ca Granda Osped Maggiore Policlin, Milan, Italy. [Stocchetti, N.] Univ Milan, Milan, Italy. [Citerio, G.] H San Gerardo Monza, Monza, Italy. [Mozzoni, L.] Icu Ceccarini Hosp Ricc, Rimini, Italy. [Sisillo, E.] Irccs Ctr Cardiol Monzino, Milan, Italy. [De Negri, P.] Irccs Ctr Riferimento Oncol Basilicata, Basilicata, Italy. [Savioli, M.] Irccs Fdn Ca Granda, Osped Maggiore Policlin, Milan, Italy. [Vecchiarelli, P.] Osped Belcolle Viterbo, Viterbo, Italy. [Puflea, F.; Stankovic, V] Osped Civile Maggiore AOUI Verona, Verona, Italy. [Minoja, G.] Osped Circolo E Fdn Macchi, Varese, Italy. [Montibeller, S.] Osped Trento, Azienda Prov I Servizi Sanitari Prov Autonoma Tre, Trento, Italy. [Calligaro, P.] Osped Orlandi, Bussolengo, Italy. [Sorrentino, R.] Osped Regionale U Parini Aosta, Aosta, Italy. [Feri, M.] Osped San Donato Arezzo, Arezzo, Italy. [Zambon, M.] Osped San Raffaele, Segrate, Italy. [Colombaroli, E.] Policlin GB Rossi AOUI Verona, Verona, Italy. [Giarratano, A.] Policlin Univ Palermo, Palermo, Italy. [Pellis, T.] Santa Maria Angeli Hosp, Rome, Italy. [Capra, C.] Saronno Hosp, Saronno, Italy. [Antonelli, M.] Univ Cattolica Sacro Cuore, Milan, Italy. [Gullo, A.] Univ Catania, Catania, Italy. [Chelazzi, C.] Univ Florence, Florence, Italy. [De Capraris, A.] Univ Foggia, Foggia, Italy. [Patroniti, N.] Univ Milano Bicocca, San Gerardo Hosp, Milan, Italy. [Girardis, M.] Univ Modena, Modena, Italy. [Franchi, F.] Univ Siena, Siena, Italy. [Berlot, G.] Univ Trieste, Trieste, Italy. [Buttigieg, M.] Mater Hosp, Msida, Malta. [Ponssen, H.] Albert Schweitzer Hosp, Dordrecht, Netherlands. [Cate, J. Ten] Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam, Netherlands. [Bormans, L.] Atrium Med Ctr Parkstad, Heerlen, Netherlands. [Husada, S.] Bovenij Hosp, Amsterdam, Netherlands. [Buise, M.] Catharina Hosp, Eindhoven, Netherlands. [Van Der Hoven, B.] Erasmus MC, Rotterdam, Netherlands. [Reidinga, A.] Martiniziekenhuis Groningen, Groningen, Netherlands. [Kuiper, M.] Med Ctr Leeuwarden, Leeuwarden, Netherlands. [Pickkers, P.] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands. [Kluge, G.] Slotervaart Ziekenhuis Amsterdam, Amsterdam, Netherlands. [Den Boer, S.] Spaarne Ziekenhuis, Hoofddrop, Netherlands. [Kesecioglu, J.] Univ Med Ctr Utrecht, Utrecht, Netherlands. [Van Leeuwen, H.] Ziekenhuis Rijnstate, Arnhem, Netherlands. [Flaatten, H.] Haukeland Hosp, Bergen, Norway. [Mo, S.] Trondheim Reg & Univ Hosp, St Olays Hosp, Trondheim, Norway. [Branco, V] Ctr Hosp Cova Da Beira, Covilha, Portugal. [Rua, F.] Ctr Hosp Porto, Porto, Portugal. [Lafuente, E.] Ctr Hosp Tamega E Sousa, Guilhufe, Portugal. [Sousa, M.] Ctr Hosp Gaia Espinho, Epe, Espinho, Portugal. [Catorze, N.] Ctr Hosp Medio Tejo, Lisbon, Portugal. [Barros, M.] Ctr Hosp Tondela Viseu, Viseu, Portugal. [Pereira, L.] Faro Hosp, Faro, Portugal. [De Oliveira, A. Vintern] Hosp Curry Cabral, Lisbon, Portugal. [Gomes, J.] Hosp Luz, Lisbon, Portugal. [Gaspar, I] Hosp Egas Moniz Chlo, Lisbon, Portugal. [Pereira, M.] Ctr Hosp Porto, Hosp Santo Antonio, Proto, Portugal. [Cymbron, M.] Hosp Divino Espirito Santo, Epe, Ponta Delgada, Portugal. [Dias, A.] Hosp Espirito Santo Evora Epe, Evora, Portugal. [Almeida, E.] Hosp Garcia Orta, Almada, Portugal. [Beirao, S.] Hosp Geral Ctr Hosp E Univ Coimbra, Coimbra, Portugal. [Serra, I] Hosp Prof Doutor Fernando Fonseca Epe, Amadora, Portugal. [Ribeiro, R.] Hosp Sao Bernardo, Setubal, Portugal. [Povoa, P.] Hosp Sao Francisco Xavier, Chlo, Lisbon, Portugal. [Faria, F.] Inst Portugues Oncol Francisco Gentil, Porto, Portugal. [Costa-E-Silva, Z.] Santa Maria Hosp, Lisbon, Portugal. [Nobrega, A.] Serv Saude Regiao Autonoma Madeira, Funchal, Portugal. [Fernandes, F.] UCIP, Lisbon, Portugal. [Gabriel, J.] ULS Castelo Branco, Castelo Branco, Portugal. [Voga, G.] Gen Hosp Celje, Celje, Slovenia. [Rupnik, E.] Gen Hosp Izola, Izola, Slovenia. [Kosec, L.] Gen Hosp Novo Mesto, Novo Mesto, Slovenia. [Povsic, M. Kerin] Oncol Inst, Ljubljana, Slovenia. [Osojnik, I] Ukc Maribor, Maribor, Slovenia. [Tomic, V] Univ Clin Resp & Allerg Dis, Golnik, Slovenia. [Sinkovic, A.] Univ Clin Ctr Maribor, Maribor, Slovenia. [Gonzalez, J.] CH Salamanca, Salamanca, Spain. [Zavala, E.] Clin Hosp, Barcelona, Spain. [Perez Valenzuela, A.] Complejo Hosp Jaen, Jaen, Spain. [Marina, L.] Complejo Hosp Toledo, Toledo, Spain. [Vidal-Cortes, P.] Complexo Hosp Univ Ourense, Orense, Spain. [Posada, I] Complexo Hosp Univ Vigo, Galicia, Spain. [Ignacio Martin-Loeches, A.] Corp Sanitaria Parc Tauli, Barcelona, Spain. [Munoz Guillen, N.] Cruz Roja Hosp, Seville, Spain. [Palomar, M.] H Vall Hebron, Barcelona, Spain. [Sole-Violan, U.] HGGC Dr Negrin, Madrid, Spain. [Torres, A.] Hosp Clin Barcelona, Barcelona, Spain. [Gonzalez Gallego, M.] Hosp Clin San Carlos, Madrid, Spain. [Aguilar, G.] Hosp Clin Univ Valencia, Valencia, Spain. [Montoiro Allue, R.] Hosp Clin Univ Lozano Blesa, Zaragoza, Spain. [Argueso, M.] Hosp Clin Valencia, Valencia, Spain. [Parejo, M.] Hosp La Ribera, Valencia, Spain. [Palomo Navarro, M.] Hosp Sagunto, Port De Sagunt, Spain. [Jose, A.] Hosp San Juan Alicante, Alicante, Spain. [Nin, N.] Hosp Torrejon de Ardoz, Madrid, Spain. [Alvarez Lerma, F.] Hosp Mar, Barcelona, Spain. [Martinez, O.] Hosp Tajo, Madrid, Spain. [Tenza Lozano, E.] Hosp Gen Univ Elche, Elche, Spain. [Arenal Lopez, S.; Perez Granda, M.] Hosp Gen Univ Gregorio Maranon, Madrid, Spain. [Moreno, S.] Hosp Gen Univ Santa Lucia, Murcia, Spain. [Llubia, C.] Hosp Badalona Germans Trias & Pujol, Barcelona, Spain. [De la Fuente Martos, C.] Hosp Infanta Margarita, Cabra, Spain. [Gonzalez-Arenas, P.] Hosp Infanta Sofia, Madrid, Spain. [Llamas Fernandez, N.; Gil Rueda, B.] Hosp JM Morales Meseguer, Murcia, Spain. [Estruch Pons, I] Hosp Marina Salu Denia Alicante, Alicante, Spain. [Cruza, N.] Hosp Nuestra Senora Prado, Toledo, Spain. [Maroto, F.] Hosp San Juan De Dios Aljarafe, Bormujos, Spain. [Estella, A.] Hosp Sas Jerez, Andalucia, Spain. [Ferrer, A.] Hosp Son Llatzer, Palma De Mallorca, Spain. [Iglesias Fraile, L.; Quindos, B.] Hosp Univ Cent Asturias, Oviedo, Spain. [Quintano, A.] Hosp Univ Alava, Santiago, Spain. [Tebar, M.] Hosp Univ Basurto, Bilbao, Spain. [Cardinal, I] Hosp Univ Getafe, Getafe, Spain. [Reyes, A.] Hosp Univ La Princesa, Madrid, Spain. [Rodriguez, A.] Hosp Univ Tarragona Joan Xxiii, Tarragona, Spain. [Abella, A.] Hosp Univ Henares, Coslada, Spain. [Garcia Del Valle, S.] Hosp Univ Fdn Alcorcon, Alcorcon, Spain. [Yus, S.; Maseda, E.] Hosp Univ La Paz, Madrid, Spain. [Berezo, U.] Hosp Univ Rio Hortega, Valladolid, Spain. [Tejero Pedregosa, A.] Hosp Univ San Cecilio, Granada, Spain. [Laplaza, C.] Hosp Virgen Del Camino, Pamplona, Spain. [Ferrer, R.] Mutua Terrassa Univ Hosp, Terrassa, Spain. [Rico-Feijoo, U.] Rao Hortega Univ Hosp, Valladolid, Spain. [Rodriguez, M.] Serv Andaluz Salud, Andalucia, Spain. [Monedero, P.] Univ Okalingaf Navarra, Navarra, Spain. [Eriksson, K.] Karolinska Univ Hosp, Solna, Sweden. [Eriksson, K.] Karolinska Inst, Solna, Sweden. [Lind, D.] Sunderby Hosp, Lulea, Sweden. [Chabanel, D.] Hop Intercantonal La Broye, Payerne, Switzerland. [Zender, H.] Hop Neuchatelois La Chaux De Fonds, La Chaux De Fonds, Switzerland. [Heer, K.] Lindenhofspital, Bern, Switzerland. [Frankenberger, B.] Regionalspital Surselva Ilanz, Ilanz, Switzerland. [Jakob, S.] Univ Hosp Bern, Bern, Switzerland. [Mathew, S.] Alexandra Hosp Redditch, Redditch, England. [Downes, R.] Blackpool Teaching Hosp, Blackpool, England. [Groba, C. Barrera] Brighton & Sussex Univ Hosp, Brighton, E Sussex, England. [Johnston, A.] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England. [Meacher, R.] Charing Cross Hosp, London, England. [Keays, R.] Chelsea & Westminster Hosp, London, England. [Haji-Michael, P.] Christie Fdn Trust, Manchester, Lancs, England. [Tyler, C.] Cty Hosp, Lincoln, England. [Ferguson, A.] Craigavon Area Hosp, Craigavon, North Ireland. [Jones, S.] Cumberland Infirm, Carlisle, England. [Tyl, D.] Darent Valley Hosp, Dartford, England. [Ball, A.] Dorset Cty Hosp, Dorchester, England. [Vogel, U.] Ealing Hosp NHS Trust, Southall, Middx, England. [Booth, M.] Glasgow Royal Infirm, Glasgow, Lanark, Scotland. [Downie, P.] Gloucester Royal Hosp, Gloucester, England. [Watters, M.] Great Western Hosp, Swindon, Wilts, England. [Brett, S.] Imperial Coll Healthcare NHS Trust, London, England. [Garfield, M.] Ipswich Hosp Nhs Trust, Ipswich, Suffolk, England. [Everett, L.] James Paget Univ Hosp NHS Fdn Trust, Great Yarmouth, Norfolk, England. [Heenen, S.] Kings Coll Hosp London, London, England. [Dhir, S.] Kings Mill Hosp, Sutton In Ashfield, England. [Beardow, Z.] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England. [Mostert, M.] Lewisham Healthcare NHS Trust, London, England. [Brosnan, S.] Luton & Dunstable Hosp NHS Trust, Luton, Beds, England. [Pinto, N.] Medway Maritime Hosp, Gillingham, England. [Harris, S.] Musgrove Pk Hosp, Taunton, Somerset, England. [Summors, A.] Nevill Hall Hosp, Abergavenny, Wales. [Andrew, N.] Pilgrim Hosp, Boston, England. [Rose, A.] Mid Yorkshire NHS Trust, Pinderfields Hosp, Wakefield, England. [Appelboam, R.] Plymouth Hosp Nhs Trust, Plymouth, Devon, England. [Davies, O.] Princess Royal Hosp Telford, Telford, Shrops, England. [Vickers, E.] Royal Bournemouth Hosp, Bournemouth, Dorset, England. [Agarwal, B.] Royal Free Hampstead NHS Fdn Trust, London, England. [Szakmany, T.] Royal Glamorgan Hosp, Llantrisant, Wales. [Wimbush, S.] Royal Hampshire Cty Hosp, Winchester, Hants, England. [Welters, I] Royal Liverpool Univ Hosp, Liverpool, Merseyside, England. [Pearse, R.] Barts Hlth NHS Trust, Royal London Hosp, London, England. [Hollands, R.] Royal Shrewsbury Hosp, Shrewsbury, Salop, England. [Kirk-Bayley, U.] Royal Surrey Cty Hosp, Guildford, Surrey, England. [Fletcher, N.] St Georges Healthcare, London, England. [Bray, B.] Surrey & Sussex Healthcare Trust, Redhill, Surrey, England. [Brealey, D.] Univ Coll Hosp, London, England.
- Published
- 2019
12. Noise-related hearing loss in workers of a thermal reactor
- Author
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Akinocal F.C., Ocal R., Adsiz G., Belgin E., Akinocal, F.C., Dept. of ENT, Gulhane Traınıng and Research Hospital, Ankara, Turkey, Ocal, R., Dept. of ENT, Ankara Traınıng and Research Hospital, Ankara, Turkey, Adsiz, G., Dept. of Audiology, Konya Traınıng and Research Hospital, Konya, Turkey, and Belgin, E., Dept. of Audiology, School of Medicine, Medipol University, Istanbul, Turkey
- Abstract
[No abstract available]
- Published
- 2017
13. The effect of intratympanic oxytocin treatment on rats exposed to acoustic trauma
- Author
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Akin Ocal, F C, primary, Kesici, G G, additional, Gurgen, S G, additional, Ocal, R, additional, and Erbek, S, additional
- Published
- 2019
- Full Text
- View/download PDF
14. Assessment of the worldwide burden of critical illness: The Intensive Care Over Nations (ICON) audit
- Author
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Vincent, J. -L., Marshall, J. C., Namendys-Silva, S. A., Francois, B., Martin-Loeches, I., Lipman, J., Reinhart, K., Antonelli, M., Pickkers, P., Njimi, H., Jimenez, E., Sakr, Y., Tomas, E., Bibonge, E. A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Zbaganu, G. V., Adriana, S., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X., Zhao, X., Li, C., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Lee, K., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W., Sin, K., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T., Hata, N., Kobe, Y., Shimomura, Y., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. N., Tai, L., Tony, B., Bigornia, R., Palo, J., Chatterjee, S., Tan, B., Kong, A., Goh, S., Lee, C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. N., Hosny, H., Ashraf, A., Mokhtari, M., Nowruzinia, S., Lotfi, A., Zand, F., Nikandish, R., Moghaddam, O. M., Cohen, J., Sold, O., Sfeir, T., Hasan, A., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Herridge, M., Fernandez, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R., Ryan, A., Prince, D., Edington, J., Van Haren, F., Bersten, A., Richards, B., Kilminster, M., Sturgess, D., Ziegenfuss, M., O'Connor, S., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M., Dias, M. D., Fontes, L., Lunardi, M., Youssef, N., Lobo, S., Silva, R., Sales, J., Melo, L. M., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. S., Costa Filho, R., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Gomez, J., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, G. C., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro, L. C., Duque, G. L., Diaz-Guio, D., Benitez, F., Urrego, A. G., Buitrago, R., Ortiz, G., Gaviria, M. V., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. C., Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., De La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. M., Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. R., Arrazola, F., Francisco, L. J., Hernandez, M., Cadena, D. R., Islas, I. L., Zarzavilla, C. B., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Q., Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Gianoni, S. M., Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Von Der Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, D., Lahkar, B., Mandal, A., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Zirpe Gurav, K., Patel, M., Bhavsar, A., Samaddar, D., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Philippe, G., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., De Waele, J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Wittebole, X., Herbert, S., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Leone, M., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Lefrant, J., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Bernard, F., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, L., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Jaschinski, U., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, M. G., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S., Barry, J., O'Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., De Oliveira, A. V., Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. K., Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, J. P., Marina, L., Vidal-Cortes, P., Posada, P., Guillen, N. M., Palomar, M., Sole-Violan, J., Torres, A., Gallego, M. G., Aguilar, G., Allue, R. M., Argueso, M., Parejo, M., Navarro, M. P., Jose, A., Nin, N., Lerma, F. A., Martinez, O., Lozano, E. T., Lopez, S. A., Granda, M. P., Moreno, S., Llubia, C., Martos Cde, L., Gonzalez-Arenas, P., Fernandez, N. L., Rueda, B. G., Pons, I. E., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, L. I., Brigida, Q., Quintano, A., Tebar, M., Frutos-Vivar, F., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. G., Yus, S., Maseda, E., Berezo, J., Pedregosa, A. T., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Mathew, S., Downes, R., Groba, C. B., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Williams, K., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Service de Réanimation Polyvalente [CHU Limoges], CHU Limoges, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Vincent, J. -L., Marshall, J. C., Namendys-Silva, S. A., Francois, B., Martin-Loeches, I., Lipman, J., Reinhart, K., Antonelli, M., Pickkers, P., Njimi, H., Jimenez, E., Sakr, Y., Tomas, E., Bibonge, E. A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Zbaganu, G. V., Adriana, S., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X., Zhao, X., Li, C., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Lee, K., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W., Sin, K., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T., Hata, N., Kobe, Y., Shimomura, Y., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. N., Tai, L., Tony, B., Bigornia, R., Palo, J., Chatterjee, S., Tan, B., Kong, A., Goh, S., Lee, C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. N., Hosny, H., Ashraf, A., Mokhtari, M., Nowruzinia, S., Lotfi, A., Zand, F., Nikandish, R., Moghaddam, O. M., Cohen, J., Sold, O., Sfeir, T., Hasan, A., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Herridge, M., Fernandez, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R., Ryan, A., Prince, D., Edington, J., Van Haren, F., Bersten, A., Richards, B., Kilminster, M., Sturgess, D., Ziegenfuss, M., O'Connor, S., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M., Dias, M. D., Fontes, L., Lunardi, M., Youssef, N., Lobo, S., Silva, R., Sales, J., Melo, L. M., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. S., Costa Filho, R., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Gomez, J., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, G. C., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro, L. C., Duque, G. L., Diaz-Guio, D., Benitez, F., Urrego, A. G., Buitrago, R., Ortiz, G., Gaviria, M. V., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. C., Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., De La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. M., Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. R., Arrazola, F., Francisco, L. J., Hernandez, M., Cadena, D. R., Islas, I. L., Zarzavilla, C. B., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Q., Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Gianoni, S. 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G., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S., Barry, J., O'Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., De Oliveira, A. V., Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. K., Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, J. P., Marina, L., Vidal-Cortes, P., Posada, P., Guillen, N. M., Palomar, M., Sole-Violan, J., Torres, A., Gallego, M. G., Aguilar, G., Allue, R. M., Argueso, M., Parejo, M., Navarro, M. P., Jose, A., Nin, N., Lerma, F. A., Martinez, O., Lozano, E. T., Lopez, S. A., Granda, M. P., Moreno, S., Llubia, C., Martos Cde, L., Gonzalez-Arenas, P., Fernandez, N. L., Rueda, B. G., Pons, I. E., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, L. I., Brigida, Q., Quintano, A., Tebar, M., Frutos-Vivar, F., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. G., Yus, S., Maseda, E., Berezo, J., Pedregosa, A. T., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Mathew, S., Downes, R., Groba, C. B., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Williams, K., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Vincent, J, Marshall, J, Ñamendys-Silva, S, François, B, Martin-Loeches, I, Lipman, J, Reinhart, K, Antonelli, M, Pickkers, P, Njimi, H, Jimenez, E, Sakr, Y, GIARRATANO, A, Namendys-Silva, S, Francois, B, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Zbaganu, G, Adriana, S, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Lee, K, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Shimomura, Y, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Mokhtari, M, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Almekhlafi, G, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Herridge, M, Fernandez, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Bauer, P, Nanchal, R, Wunderink, R, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Richards, B, Kilminster, M, Sturgess, D, Ziegenfuss, M, O'Connor, S, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, Dias, M, Fontes, L, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Costa Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Gomez, J, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Francisco, L, Hernandez, M, Cadena, D, Islas, I, Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, D, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe Gurav, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Granda, M, Moreno, S, Llubia, C, Martos Cde, L, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Brigida, Q, Quintano, A, Tebar, M, Frutos-Vivar, F, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Williams, K, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, and Brealey, D
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Critical Illness ,health care facilities, manpower, and services ,Population ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Critical care, european intensive care, icon study ,Comorbidity ,intensive care medicine ,Global Health ,MOF ,sepsis ,critically ill ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,ICON, Intensive Care ,Article ,Sepsis ,Cohort Studies ,Outcome Assessment (Health Care) ,Intensive care ,Outcome Assessment, Health Care ,Epidemiology ,Health care ,Settore MED/41 - ANESTESIOLOGIA ,medicine ,Global health ,critical illness, mortality ,Humans ,Hospital Mortality ,education ,Intensive care medicine ,education.field_of_study ,Medical Audit ,business.industry ,Intensive Care ,medicine.disease ,3. Good health ,Intensive Care Units ,ICON ,business ,Cohort study - Abstract
Item does not contain fulltext BACKGROUND: Global epidemiological data regarding outcomes for patients in intensive care units (ICUs) are scarce, but are important in understanding the worldwide burden of critical illness. We, therefore, did an international audit of ICU patients worldwide and assessed variations between hospitals and countries in terms of ICU mortality. METHODS: 730 participating centres in 84 countries prospectively collected data on all adult (>16 years) patients admitted to their ICU between May 8 and May 18, 2012, except those admitted for fewer than 24 h for routine postoperative monitoring. Participation was voluntary. Data were collected daily for a maximum of 28 days in the ICU and patients were followed up for outcome data until death or hospital discharge. In-hospital death was analysed using multilevel logistic regression with three levels: patient, hospital, and country. FINDINGS: 10,069 patients were included from ICUs in Europe (5445 patients; 54.1%), Asia (1928; 19.2%), the Americas (1723; 17.1%), Oceania (439; 4.4%), the Middle East (393; 3.9%), and Africa (141; 1.4%). Overall, 2973 patients (29.5%) had sepsis on admission or during the ICU stay. ICU mortality rates were 16.2% (95% CI 15.5-16.9) across the whole population and 25.8% (24.2-27.4) in patients with sepsis. Hospital mortality rates were 22.4% (21.6-23.2) in the whole population and 35.3% (33.5-37.1) in patients with sepsis. Using a multilevel analysis, the unconditional model suggested significant between-country variations (var=0.19, p=0.002) and between-hospital variations (var=0.43, p
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- 2014
15. Can McIsaac scores prevent the unnecessary use of antibiotics in tonsillitis?
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Ocal, F. C. Akin, Ocal, R., Kuscu, F., and Çukurova Üniversitesi
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stomatognathic system ,Acute ,diagnose ,tonsillitis ,culture - Abstract
WOS: 000414402300003 Objective: Acute tonsillitis is primarily caused by viral infection. Group A Streptococcus (GAS), however, is the only causative agent of acute tonsillitis for which there is a specific diagnosis and treatment. Nevertheless, antibiotics are commonly prescribed without a confirmed diagnosis. McIsaac criteria can be used to confirm GAS-associated acute tonsillitis. Herein, we aimed to study McIsaac criteria with throat cultures, procalcitonin (PCT) and C-reactive protein (CRP) levels, white blood cell counts (WBC), neutrophil counts and erythrocyte sedimentation values and to investigate utility of McIsaac criteria in the definitive diagnosis and treatment of acute tonsillitis. Methods: We assessed 97 patients diagnosed with acute tonsillitis. Medical files were scanned retrospectively, and WBC counts, neutrophil counts, erythrocyte sedimentation values, CRP and PCT measurements and patient throat cultures were compared with the McIsaac scores. Results: Patients were separated into two groups according to McIsaac criteria. Group one had McIsaac scores = 3. There were 29 patients in group one, and 68 patients in group two. Normal bacterial flora (NBF) were present in all group one patients, while NFB and GAS were respectively found in 52 and 16 group two patients. There was a statistically significant difference between McIsaac scores >= 3 and GAS presence in throat cultures (p < 0.05). CRP, WBC and total neutrophil counts were significantly higher in patients with throat cultures positive for GAS than in patients with GAS-negative throat cultures (p < 0.05). Conclusions: The McIsaac scoring system is useful and informative for clinicians and will reduce unnecessary antibiotic use to treat acute tonsillitis.
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- 2017
16. Assessment of the worldwide burden of critical illness: The Intensive Care Over Nations (ICON) audit
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Vincent, J, Marshall, J, Namendys-Silva, S, Francois, B, Martin-Loeches, I, Lipman, J, Reinhart, K, Antonelli, M, Pickkers, P, Njimi, H, Jimenez, E, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Zbaganu, G, Adriana, S, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Lee, K, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Shimomura, Y, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Mokhtari, M, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Almekhlafi, G, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Herridge, M, Fernandez, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Bauer, P, Nanchal, R, Wunderink, R, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Richards, B, Kilminster, M, Sturgess, D, Ziegenfuss, M, O'Connor, S, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, Dias, M, Fontes, L, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Costa Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Gomez, J, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Francisco, L, Hernandez, M, Cadena, D, Islas, I, Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, D, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe Gurav, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, 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S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Granda, M, 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C., Namendys-Silva S. A., Francois B., Martin-Loeches I., Lipman J., Reinhart K., Antonelli M., Pickkers P., Njimi H., Jimenez E., Sakr Y., Tomas E., Bibonge E. 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N., Tai L., Tony B., Bigornia R., Palo J., Chatterjee S., Tan B., Kong A., Goh S., Lee C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Mokhtari M., Nowruzinia S., Lotfi A., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Herridge M., Fernandez R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Richards B., Kilminster M., Sturgess D., Ziegenfuss M., O'Connor S., Campbell L., Mcallister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M., Dias M. D., Fontes L., Lunardi M., Youssef N., Lobo S., Silva R., Sales J., Melo L. M., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Costa Filho R., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Gomez J., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro L. C., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Gaviria M. V., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Francisco L. J., Hernandez M., Cadena D. R., Islas I. L., Zarzavilla C. B., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal D., Lahkar B., Mandal A., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe Gurav K., Patel M., Bhavsar A., Samaddar D., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Philippe G., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Herbert S., Olivier V., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V., Saarinen K., Leone M., Durocher A., Moulront S., Lepape A., Losser M., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Lefrant J., Beilouny B., Forceville X., Misset B., Jacobs F., Bernard F., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Thierry L., Moussa M., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Jaschinski U., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S., Barry J., O'Leary R., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gallego M. G., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Granda M. P., Moreno S., Llubia C., Martos Cde L., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Brigida Q., Quintano A., Tebar M., Frutos-Vivar F., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Mathew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Ferguson A., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Andrew N., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Williams K., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., and Brealey D.
- Abstract
Background: Global epidemiological data regarding outcomes for patients in intensive care units (ICUs) are scarce, but are important in understanding the worldwide burden of critical illness. We, therefore, did an international audit of ICU patients worldwide and assessed variations between hospitals and countries in terms of ICU mortality. Methods: 730 participating centres in 84 countries prospectively collected data on all adult (>16 years) patients admitted to their ICU between May 8 and May 18, 2012, except those admitted for fewer than 24 h for routine postoperative monitoring. Participation was voluntary. Data were collected daily for a maximum of 28 days in the ICU and patients were followed up for outcome data until death or hospital discharge. In-hospital death was analysed using multilevel logistic regression with three levels: patient, hospital, and country. Findings: 10 069 patients were included from ICUs in Europe (5445 patients; 54·1%), Asia (1928; 19·2%), the Americas (1723; 17·1%), Oceania (439; 4·4%), the Middle East (393; 3·9%), and Africa (141; 1·4%). Overall, 2973 patients (29·5%) had sepsis on admission or during the ICU stay. ICU mortality rates were 16·2% (95% CI 15·5-16·9) across the whole population and 25·8% (24·2-27·4) in patients with sepsis. Hospital mortality rates were 22·4% (21·6-23·2) in the whole population and 35·3% (33·5-37·1) in patients with sepsis. Using a multilevel analysis, the unconditional model suggested significant between-country variations (var=0·19, p=0·002) and between-hospital variations (var=0·43, p<0·0001) in the individual risk of in-hospital death. There was a stepwise increase in the adjusted risk of in-hospital death according to decrease in global national income. Interpretation: This large database highlights that sepsis remains a major health problem worldwide, associated with high mortality rates in all countries. Our findings also show a significant association between the risk of death and the gl
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- 2014
17. Effects of radiological extent on neutrophil/lymphocyte ratio in pulmonary sarcoidosis
- Author
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Taskin, G., Yildiz, B., Taskin, A., Tasci, C., Badem, S., Deniz, O., Turhan, U., Tozkoparan, E., Ocal, R., Dogan, D., Gumus, S., Ocal, N., and Ucar, E.
- Subjects
fungi - Abstract
OBJECTIVE: Determining the severity of sarcoidosis is based on the clinical and radiological findings of the disease and the changes in pulmonary function test results. On the other hand; studies are ongoing for objective and easy markers in this respect. Neutrophil/lymphocyte ratio (NLR) is shown as a good prognostic marker for inflammation due to tissue damage in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and radiological extent of sarcoidosis.
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- 2016
18. Inflammatory Markers In Obstructive Sleep Apnea Syndrome. May Neutrophil/lymphocyte Ratio Be A New Marker?
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Gumus, S., Ocal, N., Tozkoparan, E., Tasci, C., Ocal, R., Deniz, O., Yildiz, B., Dogan, D., Taskin, G., and Ucar, E.
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- 2016
19. Relation Of Neutrophil/lymphocyte Ratio With Radiological Extent In Pulmonary Sarcoidosis
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Deniz, O., Ocal, N., Gumus, S., Tasci, C., Taskin, A., Turhan, U., Dogan, D., Ocal, R., Tozkoparan, E., and Ucar, E.
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- 2016
20. Biopsy for the differential diagnosis of longitudinally extensive spinal cord lesions
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Tanoglu, C., primary, Kilinc Toprak, M., additional, and Ocal, R., additional
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- 2017
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21. The Clinico-Radiological Spectrum of Dyke-Davidoff-Masson Syndrome in adults
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Ayas, ZO, primary, Asil, K, additional, and Ocal, R, additional
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- 2017
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22. Appreciation of trimetazidine treatment in experimental sepsis rat model
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Tanoglu, A., primary, Yamanel, L., additional, Inal, V., additional, Ocal, R., additional, Comert, B., additional, and Bilgi, C., additional
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- 2015
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23. The association of intestinal iNOS expression and oxidative stress in experimental cirrhosis
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Ocal, R., Comert, B., Yilmaz, S., Isik, A. T., Mas, N., Uzunalimoglu, O., Savas, B., Ensari, A., and Mas, M. R.
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- 2008
24. Frequency of buccopalpebral reflex according to the stage of Parkinson disease
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Eser, H., primary, Kutlu, G., additional, Akın, U., additional, Ocal, R., additional, and Inan, L.E., additional
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- 2013
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25. Effects of radiological extent on neutrophil/ lymphocyte ratio in pulmonary sarcoidosis.
- Author
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OCAL, N., DOGAN, D., OCAL, R., TOZKOPARAN, E., DENIZ, O., UCAR, E., GUMUS, S., TASCI, C., YILDIZ, B., TASKIN, G., TASKIN, A., BADEM, S., and TURHAN, U.
- Abstract
OBJECTIVE: Determining the severity of sarcoidosis is based on the clinical and radiological findings of the disease and the changes in pulmonary function test results. On the other hand; studies are ongoing for objective and easy markers in this respect. Neutrophil/lymphocyte ratio (NLR) is shown as a good prognostic marker for inflammation due to tissue damage in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and radiological extent of sarcoidosis. PATIENTS AND METHODS: Data of 122 patients included in the study were evaluated retrospectively in terms of age, gender, complete blood count parameters, erythrocyte sedimentation rate (ESR) and radiological findings at the time of diagnosis. RESULTS: Mean NLR and ESR were significantly different between radiological stages according to chest radiography and also total HRCT score (THS) groups according to parenchymal involvement in thorax tomography (p <0.05). Mean NLR was found to be 1.28 in stage 0, 1.65 in stage 1, 2.88 in stage 2,5.47 in stage 3 and 8.48 in stage 4; 1.63 in THS group 1, 2.01 in group 2, 3.47 in group 3 and 5.46 in group 4. There were statistically significant positive correlations between NLR and WBC, NLR and THS, NLR and ESR, THS and ESR, ESR and platelet, WBC and #neutrophil, WBC and #lymphocyte. CONCLUSIONS: Our findings suggest that NLR might be used as a prognostic marker in pulmonary sarcoidosis. [ABSTRACT FROM AUTHOR]
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- 2016
26. GFP (+) MESENCHYMAL STEM CELL TRANSPLANTATION IN EXPERIMENTAL CHRONIC PANCREATITIS
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Mas, M. R., primary, Gurel, H., additional, Ural, A. U., additional, Ocal, R., additional, Tasci, I., additional, Avcu, F., additional, Yasar, M., additional, Deveci, S., additional, Comert, B., additional, Isik, A. T., additional, Mas, N., additional, and Uzunalimoglu, O., additional
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- 2008
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27. N-ACETYLCYSTEINE TREATMENT IN RAT CHRONIC PANCREATITIS
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Ocal, R., primary, Tasci, I., additional, Deveci, S., additional, Comert, B., additional, Isik, A. T., additional, Mas, N., additional, Gurel, H., additional, Uzunalimoglu, O., additional, and Mas, M. R., additional
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- 2008
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28. 254 THE ASSOCIATION OF INTESTINAL INOS EXPRESSION AND OXIDATIVE STRESS IN EXPERIMENTAL CIRRHOSIS
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Mas, M.R., primary, Savas, B., additional, Ocal, R., additional, Ensari, A., additional, Comert, B., additional, Yilmaz, S., additional, Isik, A.T., additional, Mas, N., additional, and Uzunalimoglu, O., additional
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- 2008
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29. Detrimental Effects of N-Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model
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Bulucu, F., primary, Oktenli, C., additional, Kenar, L., additional, Koc, B., additional, Ocal, R., additional, Karadurmus, N., additional, Inal, V., additional, Yamanel, L., additional, Sanisoglu, Y. S., additional, and Aydin, A., additional
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- 2007
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30. W08-P-031 Adiponectin, soluble CD40 ligand and HSCRP levels in young hypertensive males
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Sonmez, A., primary, Dogru, T., additional, Ocal, R., additional, Yilmaz, M.I., additional, Ozgurtas, T., additional, Eyileten, T., additional, Taslipinar, A., additional, Erbil, K., additional, and Kocar, I.H., additional
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- 2005
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31. Soluble CD40 Ligand Levels in Patients with Hypertension
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Sonmez, Alper, primary, Dogru, T., additional, Yilmaz, M. I., additional, Ocal, R., additional, Ozgurtas, T., additional, Kilic, S., additional, Eyileten, T., additional, Tasci, I., additional, Erbil, K., additional, and Kocar, I. H., additional
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- 2005
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32. The effect of radiologic imaging studies on the risk of secondary malignancy development in patients with hodgkin lymphoma.
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Beyan C, Kaptan K, Ifran A, Ocal R, Ulutin C, and Oztürk B
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- 2007
33. Deep cerebral venous thrombosis presenting with brain stem hemorrhage
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Ocal, R., Kavaklioglu, A., Iyigundogdu, I., Kibaroglu, S., Eda Derle, and Can, U.
34. The role of glycoprotein IIIa P1A1/A2 genotype in Turkish stroke patients
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Verdi, H., Derle, E., Yalcin, Y., Ocal, R., Kibaroglu, S., Celikkol, C., NILÜFER BAYRAKTAR, Can, U., and Atac, F. B.
35. Clinical results of carotid artery stenting versus carotid endarterctomy; a single center experience
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Akinci, T., Derle, E., Kibaroglu, S., Ocal, R., Harman, A., Kural, F., Kilinc, M., Akay, H. T., Can, U., and Ülkü Sibel Benli
36. Ischemic stroke rate in patients with the complaint of dizziness
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Guler, T., Kibaroglu, S., Eda Derle, Ocal, R., Tanoglu, C. Celikkol, and Can, U.
37. Collaborators in Acknowledgments in: Decision-Making on Withholding or Withdrawing Life Support in the ICU: A Worldwide Perspective (vol 152, pg 321, 2017)
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Tomas, E., Bibonge, E. Amisi, Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kuebler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Zbaganu, G. Valcoreanu, Adriana, S., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X., Zhao, X., Li, C., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Lee, K., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W., Sin, K., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T., Hata, N., Kobe, Y., Shimomura, Y., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. Nik, Tai, L., Tony, B., Bigornia, R., Palo, J., Chatterjee, S., Tan, B., Kong, A., Goh, S., Lee, C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. Nabil, Hosny, H., Ashraf, A., Mokhtari, M., Nowruzinia, S., Lotfi, A., Zand, F., Nikandish, R., Moghaddam, O. Moradi, Cohen, J., Sold, O., Sfeir, T., Hasan, A., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Marshall, J., Herridge, M., Fernandez, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R., Jimenez, E., Ryan, A., Prince, D., Edington, J., Haren, F., Bersten, A., Richards, B., Kilminster, M., Sturgess, D., Ziegenfuss, M., O Connor, S., Lipman, J., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M., Dias, M. D. Agostino, Fontes, L., Lunardi, M., Youssef, N., Lobo, S., Silva, R., Sales, J., Madeira Campos Melo, L., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. Souza, Costa Filho, R., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Gomez, J., Rego, L., Castro, P., Passos, J., Mendes, C., Colozza Mecatti, G., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro, L. Castro, Duque, G. Libreros, Diaz-Guio, D., Benitez, F., Urrego, A. Guerra, Buitrago, R., Ortiz, G., Villalba Gaviria, M., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. Chung, Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. Martinez, Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. Rodriguez, Arrazola, F., Juan, L., Francisco, L. Juan, Namendys-Silva, S. A., Hernandez, M., Rodriguez Cadena, D., Lopez Islas, I., Ballesteros Zarzavilla, C., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Quispe, Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Gianoni, S. Mareque, Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, D., Lahkar, B., Mandal, A., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Gurav, K. Zirpe, Patel, M., Bhavsar, A., Samaddar, D., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Philippe, G., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., Vincent, J. L., Waele, J., Rimachi, R., Gusu, D., Decker, K., Mandianga, K., Heytens, L., Wittebole, X., Herbert, S., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Leone, M., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Bernard, F., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, L., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Jaschinski, U., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Sakr, Y., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, M. Giannakou, Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S., Barry, J., O Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Hoven, B., Reidinga, A., Kuiper, M., Pickkers, P., Kluge, G., Den Boer, S., Kesecioglu, J., Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., Vintem Oliveira, A., Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. Kerin, Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Perez Valenzuela, J., Marina, L., Vidal-Cortes, P., Posada, P., Martin-Loeches, A. Ignacio, Munoz Guillen, N., Palomar, M., Sole-Violan, J., Torres, A., Gallego, M. Gonzalez, Aguilar, G., Allue, R. Montoiro, Argueso, M., Parejo, M., Palomo Navarro, M., Jose, A., Nin, N., Alvarez Lerma, F., Martinez, O., Lozano, E. Tenza, Arenal Lopez, S., Perez Granda, M., Moreno, S., Llubia, C., La Fuente Martos, C., Gonzalez-Arenas, P., Llamas Fernandez, N., Rueda, B. Gil, Pons, I. Estruch, Cruza, N., Maroto, F., Angel Estella, Ferrer, A., Fraile, L. Iglesias, Brigida, Q., Quintano, A., Tebar, M., Frutos-Vivar, F., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. Garcia, Yus, S., Maseda, E., Berezo, J., Tejero Pedregosa, A., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Mathew, S., Downes, R., Groba, C. Barrera, Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Williams, K., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., and Brealey, D.
38. HYPERBARIC OXYGEN THERAPY IN RENAL ISCHEMIA/REPERFUSION INJURY
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Ilhan, H., Yamanel, L., Comert, B., volkan inal, and Ocal, R.
39. Association of White Matter Hyperintensities With Serum Lipid Profile and Hematologic Parameters in Migraine Patients.
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Ucan Tokuc FE and Ocal R
- Abstract
Introduction Migraine is one of the most common neurological diseases. Comorbidities, especially stroke, may be observed. White matter hyperintensities are common in migraine patients. Although many factors have been associated with white matter hyperintensities, such as age, gender, migraine type, frequency, and presence of aura, the etiology of white matter hyperintensities remains unclear. We aimed to study the relationship between the development of white matter hyperintensities and serum lipid profiles and hematologic parameters in migraine patients. Methods Demographic data, comorbidities, migraine types, presence of aura, and frequency of attacks were reviewed. Cranial MRI scans, hematologic profiles, and lipid profiles were analyzed. Results The study included 51 patients with white matter hyperintensity on cranial MRI and 76 migraine patients with normal cranial MRI. High-density lipoprotein cholesterol (HDL-c) was statistically significantly higher in the patients with white matter hyperintensity in the cranial MRI (WMH+) group. A statistically significant cut-off value was found for the PLR parameter in differentiating white matter hyperintensity on cranial MRI in migraine patients. Conclusion In our study, we examined the factors contributing to the development of white matter hyperintensity in migraine patients and observed the correlation between disease duration and white matter hyperintensity. While no correlation was observed between low-density lipoprotein cholesterol (LDL-c) and white matter hyperintensity, HDL-c was dramatically elevated in patients with white matter hyperintensity. Furthermore, our study shows that PLR is a useful, easily accessible, and practical parameter for detecting the development of white matter hyperintensity in migraine patients. Larger-scale randomized studies are needed for a clearer interpretation of these findings., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Antalya Training and Research Hospital Ethics Committee issued approval 25/4/2024-5/11. The study was approved by the ethics committee of Antalya Training and Research Hospital (25/4/2024-5/11). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Ucan Tokuc et al.)
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- 2024
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40. Migraine and gasdermin D: a new perspective on the inflammatory basis of migraine.
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Ocal R, Buldukoglu OC, Hasoglan MG, Korucuk M, Cekin Y, and Ocal S
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- Humans, Male, Female, Adult, Prospective Studies, Middle Aged, Inflammation blood, Pore Forming Cytotoxic Proteins blood, Nausea etiology, Young Adult, Gasdermins, Migraine Disorders blood, Phosphate-Binding Proteins blood
- Abstract
Migraine is a common and disabling primary headache disorder and inflammation is a proposed factor in the complex ethiology of the disease. Gasdermin D (GSDMD) is a membrane pore-forming protein acting through the caspase system. End result is cell death caused by leakage of intracellular components to extracellular space which also results in inflammation. Stemming from this knowledge, the potential role of GSDMD in migraine was investigated in this prospective study. This prospective study was conducted between September 2022 to April 2023. 47 patients with migraine were designated as the patient group, whereas 47 healthy volunteers were designated as the control group. Serum GSDMD levels of both groups were compared, with an additional comparison between migraine patients during symptom-free and attack periods. Migraine related characteristics of the patients were also included in the study. Median GSDMD levels of the patient and control group did not reveal a significant difference. Nausea, vomiting and severity of headache were found to be correlated with GSDMD levels in migraine patients. Patients with nausea revealed a higher GSDMD level compared to patients without nausea during both symptom-free and attack periods (p = 0.021 and p = 0.01, respectively). Nausea was correlated to higher GSDMD levels in the patient population during symptom-free period (p = 0.030). The severity of pain was positively correlated with GSDMD levels during the attack period (p < 0.001). Gasdermin family and GSDMD in particular are promising prospects for therapy in a wide spectrum of disorders. Gasdermin proteins are candidates to be the focus for future studies both related to pathogenesis and drug therapy in migraine and varying inflammatory-driven clinical pictures., (© 2024. The Author(s) under exclusive licence to Belgian Neurological Society.)
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- 2024
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41. Eating attitudes of migraine patients in Turkey: a prospective multi-center study.
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Ocal R, Karakurum-Goksel B, Van M, Coskun O, Karaaslan C, Ucler S, Gokcay F, Celebisoy N, Sirin H, Kisabay Ak A, Saritas AS, Cerrahoglu Sirin T, Hasirci Bayir BR, Ekizoglu E, Orhan EK, Bayram D, Tanik N, Bicakci S, Ozturk V, Inan LE, Metin KM, Eren Y, Dora B, Oguz-Akarsu E, Karli N, Celik EU, Atalar AC, Gozubatik Celik RG, Mutluay B, Aydinlar EI, Yalinay Dikmen P, Semercioglu S, Emre U, Buldukoglu OC, Er B, Kilboz BB, Ibis S, Yagiz S, Koklu H, Kamaci I, Aliyeva G, Ates BE, Kara MM, Altunc FZ, Kaya I, and Sisman C
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- Humans, Turkey epidemiology, Female, Adult, Male, Prospective Studies, Case-Control Studies, Middle Aged, Young Adult, Anxiety epidemiology, Anxiety psychology, Migraine Disorders psychology, Migraine Disorders epidemiology, Feeding and Eating Disorders psychology, Feeding and Eating Disorders epidemiology, Feeding Behavior psychology, Feeding Behavior physiology
- Abstract
Background: Migraine is a disease characterized by headache attacks. The disease is multifactorial in etiology and genetic and environmental factors play role in pathogenesis. Migraine can also be accompanied by psychiatric disorders like neurotism and obsessive compulsive disorder. Stress, hormonal changes and certain food intake can trigger attacks in migraine. Previous studies showed that eating attitudes and disorders are prevalant in patients with migraine. Eating disorders are psychiatric disorders related to abnormal eating habits. Both migraine and eating disorders are common in young women and personality profiles of these patient groups are also similar. A possible relationship which shows that migraine and eating habits are related can lead to a better understanding of disease pathogenesis and subsequently new therapeutic options on both entities. Association of migraine in relation to severity, depression and anxiety and eating habits and disorders were aimed to be investigated in this study., Methods: The study was designed as a prospective, multi-center, case control study. Twenty-one centers from Turkey was involved in the study. The gathered data was collected and evaluated at a single designated center. From a pool of 1200 migraine patients and 958 healthy control group, two groups as patient group and study group was created with PS matching method in relation to age, body-mass index, marital status and employment status. Eating Attitudes Test-26 (EAT-26), Beck's Depression Inventory (BDI) and Beck's Anxiety Inventory (BAI) were applied to both study groups. The data gathered was compared between two groups., Results: EAT-26 scores and the requirement for referral to a psychiatrist due to symptoms related to eating disorder were both statistically significantly higher in patient group compared to control group (p = 0.034 and p = 0.0001 respectively). Patients with migraine had higher scores in both BDI and BAI compared to control group (p = 0.0001 and p = 0.0001 respectively). Severity of pain or frequency of attacks were not found to be related to eating attitudes (r:0.09, p = 0.055)., Conclusions: Migraine patients were found to have higher EAT-26, BDI and BAI scores along with a higher rate of referral to a psychiatrist due to symptoms. Results of the study showed that eating habits are altered in migraine patients with higher risk of eating disorders. Depression and anxiety are also found to be common amongst migraine patients., (© 2024. The Author(s).)
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- 2024
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42. Crohn's Disease and Herpes Zoster: Being Mindful of Vaccination.
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Buldukoglu OC, Ocal R, and Ocal S
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- Humans, Vaccination, Herpesvirus 3, Human immunology, Adult, Herpes Zoster Vaccine administration & dosage, Herpes Zoster Vaccine immunology, Male, Female, Crohn Disease, Herpes Zoster prevention & control
- Abstract
Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract. Immunosuppressive therapy is the main treatment modality in Crohn's disease. Herpes zoster (HZ), caused by Varicella-zoster virus, is a relatively common albeit burdensome clinical picture mainly affecting adult population with immunosuppressive status. In this paper, we aimed to report a Crohn's disease patient with HZ to raise awareness on vaccination. There are commercially available vaccines that are shown to be safe and effective against HZ reactivation. Crohn's disease patients should be evaluated and informed about preventive options against HZ to prevent unwanted HZ-related complications., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved.)
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- 2024
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43. Possible Neoplastic or Proliferative Effects of Intra-Tympanic Platelet-Rich Plasma on the MiddleEarMucosa: A Myth or a Fact to Consider?
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Arslan N, Kargin Kaytez S, Ocal R, Yumusak N, Şenes M, and Ibas M
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- Animals, Ear, Middle, Inflammation, Rats, Tympanic Membrane, Platelet-Rich Plasma, Saline Solution
- Abstract
Background: Platelet-rich plasma is a frequently used plasma-derived material; however, a possible neoplastic or proliferative effect is one of the limiting issues in its use. The aim of our experimental study was to investigate the long-term histological effects of platelet-rich plasma on the middle ear mucosa., Methods: The rats were divided into 2 groups randomly (groups 1 and 2). Group 1 represented the control group and 8 rats were included in this group. To the left ear, 0.3 mL of normal saline solution was administered intra-tympanically. No injections were done to the right ears. Group 2 represented the platelet-rich plasma group and 11 rats were included. To the left ears, 0.3 mL of platelet-rich plasma and to the right ears 0.3 mL of normal saline solution was administered intra-tympanically. The intra-tympanic platelet-rich plasma injections were done twice with an interval of 1 week. All animals were sacrificed in the third month. The degree of mucosal thickness, the presence of metaplasia, atypical cells, myofibroblastic infiltration, angiogenesis, and acute or chronic inflammation were evaluated histopathologically., Results: Histopathological findings in the right and left ears in each group were compared in itself. The degree of inflammation and mucosal thickness were significantly higher in the perforated and saline administered side, in group 1 (P < .001). In group 2, the degree of angiogenesis was significantly higher in the platelet-rich plasma administered side (P < .001). The degree of mucosal thickness was significantly higher in the saline administered side (P < .001)., Conclusion: Considering the anti-inflammatory and regenerative features and its safety, intra-tympanic-PRP may, in the future, be an alterna- tive to current intra-tympanic treatment modalities.
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- 2022
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44. The Effect of Oral Montelukast Administration in Cholesteatoma Development and Inflammation: An Experimental Animal Model.
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Ocal R, Kargin Kaytez S, Yumusak N, Akkoca O, Celik H, and Arslan N
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- Acetates, Animals, Cyclopropanes, Female, Inflammation drug therapy, Models, Animal, Quinolines, Rats, Rats, Wistar, Sulfides, Cholesteatoma, Middle Ear
- Abstract
Hypothesis: We hypothesized that oral montelukast treatment could inhibit cholesteatoma formation in an experimental animal model., Background: Inflammation and excessive proliferation have been described in the histopathology of cholesteatoma. The aim of this study was to determine the effect of oral montelukast on cholesteatoma development., Methods: Eighteen healthy female Wistar albino rats weighing 250 g were chosen for the study. The animals were divided into two groups: group 1 received montelukast and group 2 was the control group. Intratympanic propylene glycol injection was administered into the left ears and physiologic serum was instilled into the right ears of the animals on the first, eighth, and fifteenth days. The effects of montelukast administration were evaluated by histological examination of the tympanic membrane and middle ear., Results: Group 1 (montelukast group) showed significant differences in terms of cholesteatoma formation, granulation, epithelial invagination, and inflammation. Cholesteatoma formation in the left ear was observed in 2 (22%) and 8 (89%) rats in groups 1 and 2, respectively (p = 0.015)., Conclusion: Development of cholesteatoma and inflammation was significantly lower in the montelukast-administered group. Thus, oral montelukast was found effective in preventing cholesteatoma formation., Competing Interests: The authors disclose no conflicts of interest., (Copyright © 2021, Otology & Neurotology, Inc.)
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- 2021
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45. Evaluation of Neuroimaging Findings of Central Nervous System Complications in Heart Transplant Recipients.
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Turnaoglu H, Agildere AM, Kural Rahatli F, Yildirim Donmez F, Ocal R, Sezer T, Can U, Sezgin A, and Aslamaci S
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- Adolescent, Adult, Brain Abscess diagnostic imaging, Brain Abscess etiology, Central Nervous System Diseases etiology, Central Nervous System Fungal Infections diagnostic imaging, Central Nervous System Fungal Infections etiology, Child, Databases, Factual, Female, Hemorrhagic Stroke diagnostic imaging, Hemorrhagic Stroke etiology, Humans, Ischemic Stroke diagnostic imaging, Ischemic Stroke etiology, Male, Middle Aged, Posterior Leukoencephalopathy Syndrome diagnostic imaging, Posterior Leukoencephalopathy Syndrome etiology, Predictive Value of Tests, Retrospective Studies, Treatment Outcome, Turkey, Young Adult, Central Nervous System Diseases diagnostic imaging, Diffusion Magnetic Resonance Imaging, Heart Transplantation adverse effects, Neuroimaging, Tomography, X-Ray Computed
- Abstract
Objectives: In this study, we presented neuroradiologic findings and diagnoses of neurologic complications in a series of heart transplant recipients., Materials and Methods: A retrospective review was conducted at Başkent University Hospital. We searched the hospital and radiology databases and identified 109 heart transplant recipients. Thirty-one of these recipients had neuroradiologic evaluations secondary to presentation of neurologic symptoms after heart transplant, with 18 patients evaluated with computed tomography and 22 patients evaluated with magnetic resonance imaging (overlap of imaging-defined groups occurred in 9 recipients). Computed tomography and magnetic resonance imaging studies were retrieved from the Picture Archiving and Communication System, with each type of imaging retrospectively evaluated on consensus by 2 radiologists., Results: Radiopathologic findings related to symptoms were detected in 12 of the 31 study patients. The most common abnormality was posterior reversible leukoencephalopathy syndrome (5 patients, 4.6%). The other abnormalities were ischemic stroke (3 patients, 2.8%), hemorrhagic stroke (1 patient, 0.9%), intracranial abscess (2 patients, 1.8%), and intracranial dissemination of sinusoidal fungal infection and related hemorrhagic infarct (1 patient, 0.9%). The other 19 heart transplant recipients who underwent computed tomography and/or magnetic resonance imaging for neurologic complaints showed no neuroradiologic findings related to neurologic symptoms., Conclusions: Posterior reversible leukoencephalopathy syndrome and ischemic stroke were the most common neurologic complications in our heart transplant recipients. The other complications were hemorrhagic stroke, intracranial abscess, and intracranial dissemination of sinusoidal fungal infection. Neurologic complications are common in heart transplant recipients and should be identified promptly for early treatment. For the recognition of these complications, computed tomography should be performed for initial evaluation to rule out edema or hemorrhage. However, in the presence of serious neurologic symptoms that cannot be explained by computed tomography, magnetic resonance imaging should be indicated.
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- 2020
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46. Effect of probiotics in experimental otitis media with effusion.
- Author
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Kaytez SK, Ocal R, Yumusak N, Celik H, Arslan N, and Ibas M
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- Animals, Disease Models, Animal, Ear, Middle immunology, Histamine, Male, Neutrophils, Otitis Media with Effusion chemically induced, Otitis Media with Effusion immunology, Otitis Media with Effusion prevention & control, Rats, Rats, Wistar, Otitis Media with Effusion therapy, Probiotics therapeutic use
- Abstract
Objectives: The article's aim was to investigate the effects of probiotics in the experimental otitis media with effusion., Materials and Methods: Twenty-four male Wistar albino rats were used. They were divided into four groups. Experimental otitis media with effusion was created by intratympanic histamine injection. The effusion was confirmed by otomicroscopic examination 24 h after injection. Group 1; did not receive any treatment, group 2; received probiotics for 7 days after the detection of effusion, group 3; received probiotics for 7 days prior to injection of histamine, group 4; received probiotics for 7 days before injection of histamine and 7 days after detection of effusion. After detection of effusion, animals were sacrificed. Otomicroscopic evaluation was done to determine the effusion. In histopathological examination neutrophil leukocyte counts were determined in 25 areas of the sub-mucosa of the temporal bulla., Results: The otomicroscopic ear effusions' healing rate in group 1 was 10%, in group 2 was 25%, in group 3 was 50%, and in group 4 was 100% (p < 0,013). The mean counts of submucosal neutrophil leukocyte from 25 areas of the temporal bulla of group 1 was 86,8 ± 24, group 2 was 66,5 ± 21, group 3 was 66,2 ± 16, and group 4 was 26,3 ± 6,5 (p < 0,001)., Conclusion: Probiotics have a curative effect on the prevention and treatment of otitis media with effusion. This result may be related to their anti-inflammatory effects. Therefore, probiotics can be widely used in the age group at risk for otitis media with effusion as a complementary therapy by dietary supplements., Level of Evidence: NA., Competing Interests: Declaration of competing interest There is no conflict of interest in this study., (Copyright © 2020 Elsevier B.V. All rights reserved.)
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- 2020
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47. Effectiveness of bendamustine in relapsed or refractory lymphoma cases: a Turkish Oncology Group study.
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Karadurmus N, Paydas S, Esin E, Surmeli ZG, Yildiz B, Erturk I, Nayir E, Dogan M, Sumbul AT, Barista I, Gurkan E, Ocal R, Ferhanoglu B, Ozgur G, Karakas Y, Lacin S, Ozaydin S, Petekkaya HI, and Uskent N
- Abstract
Introduction: We aimed to investigate the efficacy and side effects of bendamustine in relapsed/refractory lymphoma patients in Turkey., Material and Methods: In this retrospective study, we included relapsed/refractory Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) patients who underwent multiple lines of chemotherapy. The primary endpoint was to determine the objective response and toxicity., Results: Ninety-nine patients with a median age of 59.8 years were included in the study. Eighty-one patients had NHL (follicular lymphoma: 10, diffuse large B-cell lymphoma: 27, mantle-cell lymphoma: 18, marginal zone lymphoma: 9, small lymphocytic lymphoma/chronic lymphocytic leukemia: 17) and 18 patients had HL. The patients had previously received a median of three lines of chemotherapy (range: 2-8) except autologous stem cell transplantation (ASCT); 19 patients (HL: 11, NHL: 8) had undergone ASCT. The objective response rate (ORR) was 74.3%, the complete response rate was 57% (= 53), and the partial response rate was 16.6% ( = 19). The overall survival (OS) rate at 1 year was 74.6%. The progression-free survival (PFS) rate at 1 year was 62.5%. The most common side effects were lymphopenia, anemia and neutropenia. Side effects which were observed as grade 3 and higher levels were lymphopenia (14.1%), neutropenia (10.1%) and fatigue (7.1%)., Conclusions: Objective response rate of bendamustine was found to be 74.3% in relapsed/refractory HL and NHL patients. It appears to be an effective option as a salvage treatment for patients who have previously received multiple lines of therapy., Competing Interests: The authors declare no conflict of interest., (Copyright: © 2019 Termedia & Banach.)
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- 2019
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48. Relationship between white matter hyperintensities and retinal nerve fiber layer, choroid, and ganglion cell layer thickness in migraine patients.
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Iyigundogdu I, Derle E, Asena L, Kural F, Kibaroglu S, Ocal R, Akkoyun I, and Can U
- Subjects
- Adult, Choroid physiopathology, Female, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Migraine Disorders physiopathology, Nerve Fibers pathology, Nerve Fibers physiology, Retina diagnostic imaging, Retina physiopathology, Retinal Ganglion Cells physiology, Retinal Neurons pathology, Retinal Neurons physiology, Tomography, Optical Coherence methods, White Matter physiopathology, Choroid diagnostic imaging, Migraine Disorders diagnostic imaging, Retinal Ganglion Cells pathology, White Matter diagnostic imaging
- Abstract
Aim To compare the relationship between white matter hyperintensities (WMH) on brain magnetic resonance imaging and retinal nerve fiber layer (RNFL), choroid, and ganglion cell layer (GCL) thicknesses in migraine patients and healthy subjects. We also assessed the role of cerebral hypoperfusion in the formation of these WMH lesions. Methods We enrolled 35 migraine patients without WMH, 37 migraine patients with WMH, and 37 healthy control subjects examined in the Neurology outpatient clinic of our tertiary center from May to December 2015. RFNL, choroid, and GCL thicknesses were measured by optic coherence tomography. Results There were no differences in the RFNL, choroid, or GCL thicknesses between migraine patients with and without WMH ( p > 0.05). Choroid layer thicknesses were significantly lower in migraine patients compared to control subjects ( p < 0.05), while there were no differences in RFNL and GCL thicknesses ( p > 0.05). Conclusions The 'only cerebral hypoperfusion' theory was insufficient to explain the pathophysiology of WMH lesions in migraine patients. In addition, the thinning of the choroid thicknesses in migraine patients suggests a potential causative role for cerebral hypoperfusion and decreased perfusion pressure of the choroid layer.
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- 2018
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49. Sphenoethmoid Cell: The Battle for Places Inside of the Nose Between a Posterior Ethmoid Cell and Sphenoid Sinus: 3D-Volumetric Quantification.
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Senturk M, Guler I, Azgin I, Sakarya EU, Ocal R, Agirgol B, Alatas N, Tolu I, and Kilinc M
- Abstract
Background: Sphenoethmoid cells may be above the sphenoid sinus with/ or without con-tact to optical nerve. Although sphenoethmoid cells are theoretically considered to possibly influence the sphenoid sinus volume, we could not find any study in the literature on this issue., Aims: The aim of our study was to detect sphenoethmoid cells and measure the sphenoid sinus vol-ume using multiplanar computerized tomography and also investigate the correlation between the presence of sphenoethmoid cells and the sphenoid sinus volume., Methods: Retrospectively 141 patients who had available paranasal computerized tomography images were included in this study. The sphenoid sinus volumes of each patient were calculated individually for each side, and the relationship between the presence of sphenoethmoid cell and sphenoid sinus volume was investigated., Results: Sphenoethmoid cells were detected at 106 (37.5%) of the total 282 sides in 141 patients. No gender difference was observed. The total sphenoid sinus volume was significantly lower in the group of patients who had bilateral sphenoethmoid cells than in the sphenoethmoid cell negative group. In patients with a unilateral sphenoethmoid cell, a significant decrease in the sphenoid sinus volume was observed only for the side where the sphenoethmoid cell was located., Conclusion: It was observed that the sphenoethmoid cells caused a significant reduction in the sphe-noid sinus volume on the side where they were located. In the case of low sphenoid sinus aeration, the sphenoethmoid cell should be kept in mind. Further studies with an extended patient series are required to explore this issue.
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- 2017
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50. Noise-related Hearing Loss in Workers of a Thermal Reactor.
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Akinocal FC, Ocal R, Adsiz G, and Belgin E
- Abstract
Competing Interests: Conflict of Interests The authors declare that there is no conflict of interests.
- Published
- 2017
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