1. Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
- Author
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Alan J. Burns, Charles K. Kaufman, Clare V. H. Baker, Abigail S. Tucker, Ela W. Knapik, Heiko Lickert, Benjamin Jevans, Keith P. Gates, Christian Mosimann, Gokhan Unlu, Shannon Fisher, Joseph J. Lancman, Leonard I. Zon, Dorit Hockman, Alessandro Mongera, Gerhard Schlosser, P Duc S Dong, Clinical Genetics, University of Zurich, Baker, Clare V H, Department of Molecular and Cell Biology, Faculty of Science, Baker, Clare [0000-0002-4434-3107], and Apollo - University of Cambridge Repository
- Subjects
0301 basic medicine ,Technology ,Mouse ,Xenopus ,Glomus cell ,2400 General Immunology and Microbiology ,CAROTID-BODY ,Biomedicine - Other Topics ,Biology (General) ,PULMONARY NEUROENDOCRINE CELLS ,Chicken ,Developmental Biology ,Stem Cells ,Zebrafish ,Science & ,Catecholaminergic ,General Neuroscience ,Neural crest ,2800 General Neuroscience ,Lampreys ,NEURAL CREST CONTRIBUTIONS ,General Medicine ,Anatomy ,Biological Evolution ,carotid body ,10124 Institute of Molecular Life Sciences ,Cell Hypoxia ,Cell biology ,Neuroepithelial cell ,medicine.anatomical_structure ,ZEBRAFISH CORNEA ,GILL NEUROEPITHELIAL CELLS ,embryonic structures ,Medicine ,Carotid body ,sea lamprey (Petromyzon marinus) ,Stem cell ,Anura ,Insight ,neural crest ,animal structures ,QH301-705.5 ,Science ,Biology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,developmental biology ,Neuroendocrine Cells ,stem cells ,1300 General Biochemistry, Genetics and Molecular Biology ,medicine ,XENOPUS-LAEVIS ,Animals ,Cell Lineage ,endoderm ,General Immunology and Microbiology ,Evolutionary Developmental Biology ,neuroepithelial cells ,Life Sciences & ,biology.organism_classification ,mammalian carotid-body ,Biomedicine ,030104 developmental biology ,Developmental Biology and Stem Cells ,PROGENITOR CELLS ,CATECHOLAMINE RESPONSE ,OXYGEN CHEMORECEPTORS ,570 Life sciences ,biology ,ARTERIAL CHEMORECEPTORS ,Other ,fate-mapping ,Pharyngeal arch - Abstract
The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive ‘neuroepithelial cells’ (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.
- Published
- 2017
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