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Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
- Source :
- eLife, 6:e21231. eLife Sciences Publications, eLife, Hockman, D, Burns, A J, g, S, KP, G, B, J, A, M, Fisher, S, G, U, EW, K, CW, K, C, M, Zon, L I, JJ, L, PD, D, Lickert, H, Tucker, A S & Baker, C V H 2017, ' Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes ', eLife, vol. 6, 21231 . https://doi.org/10.7554/eLife.21231, ELife, eLife, Vol 6 (2017), eLife 6:e21231 (2017)
- Publication Year :
- 2017
-
Abstract
- The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive ‘neuroepithelial cells’ (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.
- Subjects :
- 0301 basic medicine
Technology
Mouse
Xenopus
Glomus cell
2400 General Immunology and Microbiology
CAROTID-BODY
Biomedicine - Other Topics
Biology (General)
PULMONARY NEUROENDOCRINE CELLS
Chicken
Developmental Biology
Stem Cells
Zebrafish
Science &
Catecholaminergic
General Neuroscience
Neural crest
2800 General Neuroscience
Lampreys
NEURAL CREST CONTRIBUTIONS
General Medicine
Anatomy
Biological Evolution
carotid body
10124 Institute of Molecular Life Sciences
Cell Hypoxia
Cell biology
Neuroepithelial cell
medicine.anatomical_structure
ZEBRAFISH CORNEA
GILL NEUROEPITHELIAL CELLS
embryonic structures
Medicine
Carotid body
sea lamprey (Petromyzon marinus)
Stem cell
Anura
Insight
neural crest
animal structures
QH301-705.5
Science
Biology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
developmental biology
Neuroendocrine Cells
stem cells
1300 General Biochemistry, Genetics and Molecular Biology
medicine
XENOPUS-LAEVIS
Animals
Cell Lineage
endoderm
General Immunology and Microbiology
Evolutionary Developmental Biology
neuroepithelial cells
Life Sciences &
biology.organism_classification
mammalian carotid-body
Biomedicine
030104 developmental biology
Developmental Biology and Stem Cells
PROGENITOR CELLS
CATECHOLAMINE RESPONSE
OXYGEN CHEMORECEPTORS
570 Life sciences
biology
ARTERIAL CHEMORECEPTORS
Other
fate-mapping
Pharyngeal arch
Subjects
Details
- ISSN :
- 2050084X
- Database :
- OpenAIRE
- Journal :
- eLife, 6:e21231. eLife Sciences Publications, eLife, Hockman, D, Burns, A J, g, S, KP, G, B, J, A, M, Fisher, S, G, U, EW, K, CW, K, C, M, Zon, L I, JJ, L, PD, D, Lickert, H, Tucker, A S & Baker, C V H 2017, ' Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes ', eLife, vol. 6, 21231 . https://doi.org/10.7554/eLife.21231, ELife, eLife, Vol 6 (2017), eLife 6:e21231 (2017)
- Accession number :
- edsair.doi.dedup.....9b40e0a9a9114b25e6469c5d1bb9e5a4
- Full Text :
- https://doi.org/10.7554/eLife.21231