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1. Exploring participant’s experiences in a multifamily therapy group on schizophrenia : a qualitative approach

Author

O. Amiot, C. Genis, L. Champlon, S. Said, and L. Baziret

Subjects
Psychiatry, RC435-571
Abstract

Introduction Prevention of relapse in schizophrenia is a major public health issue. A recent network meta-analysis investigating interventions for relapse prevention in schizophrenia found that the efficacity of family psychoeducation and systemic integrated interventions were superior to treatment as usual at 12 months (Bighelli I, Leucht S et al. Lancet Psychiatry 2021). Other studies also found that multi-family therapies (MFT) were superior to treatment as usual and family psychoeducation in preventing relapses at 2 and 4 years (McFarlane WR, Lukens EP et al. Archives of General Psychiatry.1995). Considering this, we developped in our community center an MFT program based on systemic approach and psychoeducation. Objectives Investigate the subjective experience of participants of an MFT group focusing on schizophrenia. Methods A qualitative study was designed to explore personal experience of participants using the Interpretative Phenomenological Analysis (IPA) method in order to analyse participant’s feedback during semi-directive interviews. By using IPA, participants are experts of their experience. Eight participants took part in this study: 4 patients and 4 parents. Results Within all participant’s feedback around 10 different themes emerged. We identified three major themes which we have described as: “Affiliation to the group”, “Framework of Discovery”, “Benefits of MFT”. According to “Affiliation to the group”, all participants report movements of adhesion or rejection towards the group. This theme has been subdivided into two sub-themes: “Temporality”, and “Identification/differentiation”. These sub-themes revealed inter-individuals’ differences. According to “Framework of discovery”, the MFT group has been identified as a secure place allowing self and other’s discovery place. This theme has been divided into two sub-themes: “discovering skills” and “improving oneself and relatives’ understanding”. Participants experience taking a step back and decentering oneself from usual personnal position. According to “Benefits of MFT”, participants report the feeling of belonging to a group, the impact on self-esteem, on mentalization skills, and on the reflexion on family members’ experience of the disease. Conclusions This study is, to our knowledge, the first qualitative study examining the subjective experience of members who participated in a psychoeducational and systemic MFT group focusing on schizophrenia. It provides insight into the families’ experience, both from the patient’s and from each family member’s perspective. Results highlight that participants seized the MFT group as a learning space at several levels: personal, intra-family and inter-family. These data could enlighten professionals working with families on the potential apprehensions of participants, their representations of the group and what process MFT could initiate. Disclosure of Interest None Declared

Published
2024
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2. Who benefits from multifamily psychoeducation groups ? Descriptive anaysis of participants

Author

O. Amiot, C. Genis, L. Baziret, L. Champlon, and S. Saïd

Subjects
Psychiatry, RC435-571
Abstract

Introduction Guidelines for relapse prevention in schizophrenia recommend psychoeducation for patients and caregivers (Bighelli I, Leucht S et al. Lancet Psychiatry 2021). Considering that, in 2021, we implemented in our Psychiatric community center a multifamily therapy (MFT). The program is based on systemic approach and psychoeducation, focusing on schizophrenia. Objectives Describe participants of MFT groups focusing on schizophrenia. * Patients’ characteristics : age, gender, duration of psychiatric follow-up, history of hospitalization * Caregivers’ characterics: status, age. Methods We carried out a descriptive study of the different profile of MFT groups participants in our community center from 2021 to today. Results Since 2021, 4 MFT groups took place including 50 participants: 18 patients suffering from schizophrenia and 32 relatives. Image 1 illustrates the different participants of each group. Each group was different. Some patients came with both their parents, even if divorced, some came only with their mother. Some came with a sibling. Nevertheless, the numbers of fathers and siblings did not always allow us to work in sub-groups. Considering patients: 18 patients benefited from our program. 8 female and 10 male patients (55.6%) were admitted and distributed in each group as described in image 2. The mean age of patients was 31.9 years old [20.1 – 57.5]. Each group was made up of patients with psychiatric follow-up ranging from 1 year to more than 20 years, and having experienced between 1 to more than 5 psychiatric hospitalizations. It appears that Group 4 was noticeably younger than the other groups with a mean age of 22.4 years old [20.4 – 26.7] and a shorter history in psychiatry with less hospitalisations (image 3). Considering relatives: 15 mothers, 9 fathers, 5 siblings, 1 spouse, 1 aunt and 1 uncle benefited from psychoeducation to caregivers. The relatives were from 47 to 81 years old for the parents, and from 17 to 50,7 for the siblings. Unlike parents, siblings generally attended a limited number of sessions. Image: Image 2: Image 3: Conclusions This descriptive study reflects the work carried out with 18 patients and their relatives in an MFT group providing psychoeducation to patients suffering from schizophrenia and their caregivers. 50 persons benefited from psychoeducation in 2 years. We learned from these results to improve the constitution of our groups and the benefits of our psychoeducation program. We were careful to include families with siblings as we know they are affected by the mental illness in the family and are often left aside of all care/support proposals. We questioned ourselves on the advantages of homogeneous or heterogeneous groups, considering age, history of follow up. How could it impact affiliation to the group or differentiation movements ? How useful or harmful it is for sharing experiences between the families. A proper study would be necessary to answer these questions. Disclosure of Interest None Declared

Published
2024
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4. Pandémie de grippe A H1N1 2009 et grossesse : épidémiologie, diagnostic et prise en charge

Author

V. Martinez, Christelle Vauloup-Fellous, Hervé Fernandez, C. Dupont-Bernabe, Olivier Picone, René Frydman, O. Ami, M. Guillet, C. Trichot, A.-C. Donnadieu, and M. V. Senat

Subjects
Maternity and Midwifery
Abstract

Resume La grippe A (H1N1) 2009 est une maladie benigne chez l’adulte sain. Du fait de la pandemie actuelle, l’Organisation mondiale de la sante (OMS) craint qu’une personne sur trois ne soit infectee dans le monde avant la fin du mois de janvier 2010. Le diagnostic de grippe A (H1N1) 2009 est suspecte devant l’association de signes cliniques d’atteinte des voies aeriennes tels que maux de gorge, toux ou dyspnee, avec des signes generaux tels que de la fievre, ou des myalgies, ou une asthenie. Le diagnostic est confirme par un prelevement nasopharynge et la recherche du virus H1N1 par biologie moleculaire. Cette grippe peut avoir des consequences graves pour la femme enceinte et pour le fœtus. Pour cette raison, il est recommande de traiter systematiquement les femmes enceintes par un antiviral tel que le Tamiflu® (oseltamivir) a doses curatives, et meme de traiter de facon preventive en cas de contage avere avec une personne infectee par l’oseltamivir Tamiflu® ou le zanamivir Relenza®. Un traitement antibiotique doit egalement etre discute en fonction des situations cliniques. Bien que la gestion des femmes enceintes face a l’infection de grippe A (H1N1) 2009 repose sur les medecins generalistes et les gynecologues de ville, tous les praticiens amenes a les prendre en charge doivent maintenir regulierement leurs connaissances a jour en fonction de l’evolution de la pandemie.

Published
2010

5. First-trimester nuchal abnormalities secondary to dehydrated hereditary stomatocytosis

Author

O. Ami, M. V. Senat, L. Garçon, Olivier Picone, Jean Delaunay, C. Castel, René Frydman, and C. Guitton

Subjects
Pathology, medicine.medical_specialty, business.industry, Obstetrics and Gynecology, Cystic hygroma, medicine.disease, Infant newborn, First trimester, Nuchal translucency, Nuchal Translucency Measurement, Dehydrated hereditary stomatocytosis, Medicine, Congenital disease, business, Genetics (clinical), Stomatocytosis
Published
2009

6. Deprexis® Acceptability study in REal life (DARE): study design

Author

O. Amiot, A. H. Clair, P. Courtet, E. Fakra, V. Narboni, F. Gheysen, E. Haffen, D. Drapier, and L. Lecardeur

Subjects
Psychiatry, RC435-571
Abstract

Introduction Depression is a leading cause of disability, worldwide. Recently, WHO highlighted the negative impact of recent crises (COVID-19 pandemic, war in Ukraine, economic crisis). Although most international guidelines recommend psychotherapies as first-line treatment of depression, access remains scarce in France due to limited availability of trained clinicians (notably those with CBT certification), high cost for patient in a context of non-reimbursement and fear of stigmatization (Coldefy M. HCAA, 2022/04,19). Therefore, online blended psychological treatment such as deprexis® could increase access to care for people with depression. It presents several advantages such as easy access, scalability, and a proven efficacy (Twomey et al. PLoS One. 2020;15(1):e022810). Objectives This study aims to test real-life acceptability of deprexis® for people with depression in France outside a reimbursement pathway. Primary objective of this cross-sectional study is to measure acceptability of deprexis® a new digital therapy in France. Questionnaire includes acceptability of deprexis® assessed with patient willingness to complete deprexis® course, reasons of refusal, when needed, demographics and depression characteristics. The secondary objectives are to study 1/ acceptability according to type of center (Hospital based, Community Based or private practice) and type of practitioners (psychiatrists or psychologists), 2/ differences in acceptability according to severity’s level (evaluated with PHQ 9), 3/ differences in acceptability according to administration or not of a treatment (including psychotherapy), 4/ differences in acceptability according to prescriber’s profile (age, sex, place and type of practice), 5/ identification of reasons for refusal , and 6/ analyze refusal rate over time. Methods DARE is as a cross-sectional study in which deprexis® is suggested to any patient meeting the inclusion criteria over the fixed inclusion period June-December 2022 Inclusion criteria are: 1/ depression, 2/ age between 18 and 65 years, 3/ speak French sufficiently, 4/ access to Internet with a device to connect to deprexis® platform. Exclusion criteria are diagnosis of bipolar disorder, psychotic symptoms and/or suicidal thoughts during the current episode. All investigators received a video-based training on deprexis® before inclusion to make sure they all have same level of information and understanding on the program. Results The study is currently recruiting. Data will be available for EPA congress. Conclusions It is a first time a digital therapy is completing the current therapeutic options for the treatment of depression in France. Acceptability of this innovation by both patients and Healthcare providers is a first step. DARE may allow to have a better understanding of the acceptability of a digital therapy in the treatment of depression in France and identify the different factors influencing it in a natural setting. Disclosure of Interest O. Amiot Consultant of: Ethypharm Digital Therapy, A. H. Clair Consultant of: Ethypharm Digital Therapy, P. Courtet Consultant of: Ethypharm Digital Therapy, E. Fakra Consultant of: Ethypharm Digital Therapy, V. Narboni Employee of: Ethypharm Digital Therapy, F. Gheysen Consultant of: Ethypharm Digital Therapy, E. Haffen Consultant of: Ethypharm Digital Therapy, D. Drapier Consultant of: Ethypharm Digital Therapy, L. Lecardeur Consultant of: Ethypharm Digital Therapy

Published
2023
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7. Sudden cardiac death prevention in the era of novel heart failure medications

Author

I. Koev, M. Yarkoni, D. Luria, O. Amir, and Y. Biton

Subjects
Sudden cardiac death, Heart failure with reduced ejection fraction, ICD, Therapy, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Sudden cardiac death (SCD) occurs unexpectedly and is usually a result of ventricular arrhythmia in patients with structural heart disease. The implantable cardioverter-defibrillator (ICD), with or without biventricular pacing, has been proven to be protective for heart failure patients with reduced ejection fraction of

Published
2023
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8. La modelisation tridimensionnelle en morphologie

Author

Plaisant O, O. Ami, Jean-François Uhl, and Delmas

Subjects
Clinical Practice, Tomography x ray computed, Interactivity, business.industry, Human–computer interaction, Computer science, Computation, 3D reconstruction, Anatomy, 3D modeling, business, Field (computer science)
Abstract

The aim of this paper is to show the major role played by the new computerized imaging tools available today in the fields of morphology and anatomy. For anatomical studies or educational purpose, they enhance the classical techniques. The 3D reconstruction, already used in daily clinical practice, will be the basis for computation of validated volumetric protocols enhancing our diagnosis and prognosis means. It is also a fantastic educational tool: the interactivity makes it simple, efficient, attractive and easily accessible and diffusable. For the research, mathematical modeling of embryogenesis and morphogenesis using finite elements method will open new ways for biomecanics and a dynamic quantification approach.

Published
2006

9. Animation vectorielle tridimensionnelle d’un fœtus à partir d’imagerie par résonance magnétique pour simulation d’accouchement

Author

O. Ami, Louis Boyer, D. Rocas, Gérard Mage, B. Rabischong, Pascal Chabrot, and Vincent Delmas

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging
Abstract

a reconstruction tridimensionnelle (3D) a partir d’imagerie par resonance magnetique nucleaire (IRM) (1) d’echographie (2) ou de scanner (3) peut etre obtenue par technique en nuage de points, encore appelee « volume rendering » par les anglo-saxons, ou bien par une technique dite vectorielle qui necessite l’elaboration d’un maillage polygonal de type « fil de fer » moulant la surface des structures (4, 5). Cette derniere technique permet d’effectuer des evaluations volumiques precises, de realiser des comparaisons dynamiques, d’appliquer des deformations et d’animer les objets tridimensionnels. Un certain nombre de proprietes physiques et mecaniques peuvent egalement etre conferees a ces objets 3D, en vue d’une simulation en realite virtuelle a partir des donnees reelles des patients. Les techniques d’animation sont bien connues du monde informatique, et peuvent desormais servir a des applications medicales concretes. Nous presentons une technique d’animation fœtale a partir de reconstruction 3D vectorielle de patientes reelles, qui pourrait servir a la mise au point d’une serie d’outils de simulation d’accouchement pour la detection en routine des dystocies mecaniques.

Published
2010

10. Cytomégalovirus et grossesse

Author

O. Ami, C. Vauloup-Fellous, A.-E. Mas, J. de Laveau-Coupet, L. Grangeot-Keros, and O. Picone

Published
2011

11. Détection des disproportions fœtopelviennes par réalité virtuelle : étude de faisabilité à propos de trois cas

Author

O. Ami, Gérard Mage, D. Rocas, Vincent Delmas, K. Jardon, Pascal Chabrot, Louis Boyer, Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), CHU Clermont-Ferrand, Air Normand, and SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
0303 health sciences, 030219 obstetrics & reproductive medicine, Radiological and Ultrasound Technology, business.industry, Vaginal delivery, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030301 anatomy & morphology, Pelvimetry, Macrosomic fetus, Computer software, Medicine, Radiology, Nuclear Medicine and imaging, Fetal head, Narrow pelvis, Fetus size, business, Nuclear medicine, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Pelvis, ComputingMilieux_MISCELLANEOUS
Abstract

Routine daily practice shows that successful vaginal delivery for women with suspected narrow pelvis or large fetus remains possible. We present a computer software for the detection of fetopelvic disproportion based on 3D vectorial reconstructions of the fetal head and maternal pelvis with simulation of head passage through the pelvis for collision detection. Three delivery simulations were generated from MR pelvimetry data in two patients, one with narrow pelvis and the other with macrosomic fetus. Based on the simulation, fetus size in both cases was appropriate for the pelvic size, but delivery simulation for the macrosomic fetus concluded that vaginal delivery was mechanically impossible. Further evaluation of this promising software on a larger patient population is necessary.

Published
2011

13. [Tridimensional vector animation from fetal MRI as a simulation of delivery]

Author

O, Ami, P, Chabrot, B, Rabischong, D, Rocas, V, Delmas, L, Boyer, G, Mage, Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand, Air Normand, and SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)

Subjects
Models, Anatomic, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Imaging, Three-Dimensional, MESH: Models, Anatomic, Labor Presentation, MESH: Magnetic Resonance Imaging, User-Computer Interface, Fetus, Imaging, Three-Dimensional, MESH: Pregnancy, MESH: Computer Simulation, Pregnancy, Computer Graphics, Image Processing, Computer-Assisted, Humans, Computer Simulation, Pelvic Bones, ComputingMilieux_MISCELLANEOUS, MESH: User-Computer Interface, MESH: Humans, MESH: Pelvic Bones, MESH: Fetus, Delivery, Obstetric, Magnetic Resonance Imaging, MESH: Image Processing, Computer-Assisted, MESH: Labor Presentation, Female, MESH: Delivery, Obstetric, MESH: Computer Graphics, MESH: Female, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience

Published
2010

14. The ATLAS Inner Detector commissioning and calibration

Author

The ATLAS Collaboration Aad, G. Abbott, B. Abdallah, J. Abdelalim, A.A. Abdesselam, A. Abdinov, O. Abi, B. Abolins, M. Abramowicz, H. Abreu, H. Acharya, B.S. Adams, D.L. Addy, T.N. Adelman, J. Adorisio, C. Adragna, P. Adye, T. Aefsky, S. Aguilar-Saavedra, J.A. Aharrouche, M. Ahlen, S.P. Ahles, F. Ahmad, A. Ahsan, M. Aielli, G. Akdogan, T. Åkesson, T.P.A. Akimoto, G. Akimov, A.V. Aktas, A. Alam, M.S. Alam, M.A. Albrand, S. Aleksa, M. Aleksandrov, I.N. Alexa, C. Alexander, G. Alexandre, G. Alexopoulos, T. Alhroob, M. Aliev, M. Alimonti, G. Alison, J. Aliyev, M. Allport, P.P. Allwood-Spiers, S.E. Almond, J. Aloisio, A. Alon, R. Alonso, A. Alviggi, M.G. Amako, K. Amelung, C. Amorim, A. Amorós, G. Amram, N. Anastopoulos, C. Andeen, T. Anders, C.F. Anderson, K.J. Andreazza, A. Andrei, V. Anduaga, X.S. Angerami, A. Anghinolfi, F. Anjos, N. Annovi, A. Antonaki, A. Antonelli, M. Antonelli, S. Antos, J. Antunovic, B. Anulli, F. Aoun, S. Arabidze, G. Aracena, I. Arai, Y. Arce, A.T.H. Archambault, J.P. Arfaoui, S. Arguin, J.-F. Argyropoulos, T. Arik, M. Armbruster, A.J. Arnaez, O. Arnault, C. Artamonov, A. Arutinov, D. Asai, M. Asai, S. Asfandiyarov, R. Ask, S. Åsman, B. Asner, D. Asquith, L. Assamagan, K. Astvatsatourov, A. Atoian, G. Auerbach, B. Augsten, K. Aurousseau, M. Austin, N. Avolio, G. Avramidou, R. Ay, C. Azuelos, G. Azuma, Y. Baak, M.A. Bach, A.M. Bachacou, H. Bachas, K. Backes, M. Badescu, E. Bagnaia, P. Bai, Y. Bain, T. Baines, J.T. Baker, O.K. Baker, M.D. Baker, S. Dos Pedrosa, F.B.S. Banas, E. Banerjee, P. Banerjee, S. Banfi, D. Bangert, A. Bansal, V. Baranov, S.P. Barashkou, A. Barber, T. Barberio, E.L. Barberis, D. Barbero, M. Bardin, D.Y. Barillari, T. Barisonzi, M. Barklow, T. Barlow, N. Barnett, B.M. Barnett, R.M. Baroncelli, A. Barr, A.J. Barreiro, F. Guimarães da Costa, J.B. Barrillon, P. Bartoldus, R. Bartsch, D. Bates, R.L. Batkova, L. Batley, J.R. Battaglia, A. Battistin, M. Bauer, F. Bawa, H.S. Bazalova, M. Beare, B. Beau, T. Beauchemin, P.H. Beccherle, R. Bechtle, P. Beck, G.A. Beck, H.P. Beckingham, M. Becks, K.H. Beddall, A.J. Beddall, A. Bednyakov, V.A. Bee, C. Begel, M. Harpaz, S.B. Behera, P.K. Beimforde, M. Belanger-Champagne, C. Bell, P.J. Bell, W.H. Bella, G. Bellagamba, L. Bellina, F. Bellomo, M. Belloni, A. Belotskiy, K. Beltramello, O. Ami, S.B. Benary, O. Benchekroun, D. Bendel, M. Benedict, B.H. Benekos, N. Benhammou, Y. Benjamin, D.P. Benoit, M. Bensinger, J.R. Benslama, K. Bentvelsen, S. Beretta, M. Berge, D. Kuutmann, E.B. Berger, N. Berghaus, F. Berglund, E. Beringer, J. Bernabéu, J. Bernat, P. Bernhard, R. Bernius, C. Berry, T. Bertin, A. Besana, M.I. Besson, N. Bethke, S. Bianchi, R.M. Bianco, M. Biebel, O. Biesiada, J. Biglietti, M. Bilokon, H. Bindi, M. Bingul, A. Bini, C. Biscarat, C. Bitenc, U. Black, K.M. Blair, R.E. Blanchard, J.-B. Blanchot, G. Blocker, C. Blondel, A. Blum, W. Blumenschein, U. Bobbink, G.J. Bocci, A. Boehler, M. Boek, J. Boelaert, N. Böser, S. Bogaerts, J.A. Bogouch, A. Bohm, C. Bohm, J. Boisvert, V. Bold, T. Boldea, V. Bondarenko, V.G. Bondioli, M. Boonekamp, M. Bordoni, S. Borer, C. Borisov, A. Borissov, G. Borjanovic, I. Borroni, S. Bos, K. Boscherini, D. Bosman, M. Boterenbrood, H. Bouchami, J. Boudreau, J. Bouhova-Thacker, E.V. Boulahouache, C. Bourdarios, C. Boveia, A. Boyd, J. Boyko, I.R. Bozovic-Jelisavcic, I. Bracinik, J. Braem, A. Branchini, P. Brandt, A. Brandt, G. Brandt, O. Bratzler, U. Brau, B. Brau, J.E. Braun, H.M. Brelier, B. Bremer, J. Brenner, R. Bressler, S. Britton, D. Brochu, F.M. Brock, I. Brock, R. Brodet, E. Bromberg, C. Brooijmans, G. Brooks, W.K. Brown, G. Bruckman de Renstrom, P.A. Bruncko, D. Bruneliere, R. Brunet, S. Bruni, A. Bruni, G. Bruschi, M. Bucci, F. Buchanan, J. Buchholz, P. Buckley, A.G. Budagov, I.A. Budick, B. Büscher, V. Bugge, L. Bulekov, O. Bunse, M. Buran, T. Burckhart, H. Burdin, S. Burgess, T. Burke, S. Busato, E. Bussey, P. Buszello, C.P. Butin, F. Butler, B. Butler, J.M. Buttar, C.M. Butterworth, J.M. Byatt, T. Caballero, J. Cabrera Urbán, S. Caforio, D. Cakir, O. Calafiura, P. Calderini, G. Calfayan, P. Calkins, R. Caloba, L.P. Calvet, D. Camarri, P. Cameron, D. Campana, S. Campanelli, M. Canale, V. Canelli, F. Canepa, A. Cantero, J. Capasso, L. Garrido, M.D.M.C. Caprini, I. Caprini, M. Capua, M. Caputo, R. Caramarcu, C. Cardarelli, R. Carli, T. Carlino, G. Carminati, L. Caron, B. Caron, S. Montoya, G.D.C. Montero, S.C. Carter, A.A. Carter, J.R. Carvalho, J. Casadei, D. Casado, M.P. Cascella, M. Castaneda Hernandez, A.M. Castaneda-Miranda, E. Gimenez, V.C. Castro, N.F. Cataldi, G. Catinaccio, A. Catmore, J.R. Cattai, A. Cattani, G. Caughron, S. Cavalleri, P. Cavalli, D. Cavalli-Sforza, M. Cavasinni, V. Ceradini, F. Cerqueira, A.S. Cerri, A. Cerrito, L. Cerutti, F. Cetin, S.A. Chafaq, A. Chakraborty, D. Chan, K. Chapman, J.D. Chapman, J.W. Chareyre, E. Charlton, D.G. Chavda, V. Cheatham, S. Chekanov, S. Chekulaev, S.V. Chelkov, G.A. Chen, H. Chen, S. Chen, X. Cheplakov, A. Chepurnov, V.F. Cherkaoui El Moursli, R. Tcherniatine, V. Chesneanu, D. Cheu, E. Cheung, S.L. Chevalier, L. Chevallier, F. Chiefari, G. Chikovani, L. Childers, J.T. Chilingarov, A. Chiodini, G. Chizhov, V. Choudalakis, G. Chouridou, S. Christidi, I.A. Christov, A. Chromek-Burckhart, D. Chu, M.L. Chudoba, J. Ciapetti, G. Ciftci, A.K. Ciftci, R. Cinca, D. Cindro, V. Ciobotaru, M.D. Ciocca, C. Ciocio, A. Cirilli, M. Clark, A. Clark, P.J. Cleland, W. Clemens, J.C. Clement, B. Clement, C. Coadou, Y. Cobal, M. Coccaro, A. Cochran, J. Coggeshall, J. Cogneras, E. Colijn, A.P. Collard, C. Collins, N.J. Collins-Tooth, C. Collot, J. Colon, G. Conde Muiño, P. Coniavitis, E. Conidi, M.C. Consonni, M. Constantinescu, S. Conta, C. Conventi, F. Cooke, M. Cooper, B.D. Cooper-Sarkar, A.M. Cooper-Smith, N.J. Copic, K. Cornelissen, T. Corradi, M. Corriveau, F. Corso-Radu, A. Cortes-Gonzalez, A. Cortiana, G. Costa, G. Costa, M.J. Costanzo, D. Costin, T. Côté, D. Torres, R.C. Courneyea, L. 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Mount, R. Mountricha, E. Mouraviev, S.V. Moyse, E.J.W. Mudrinic, M. Mueller, F. Mueller, J. Mueller, K. Müller, T.A. Muenstermann, D. Muir, A. Munwes, Y. Garcia, R.M. Murray, W.J. Mussche, I. Musto, E. Myagkov, A.G. Myska, M. Nadal, J. Nagai, K. Nagano, K. Nagasaka, Y. Nairz, A.M. Nakamura, K. Nakano, I. Nakatsuka, H. Nanava, G. Napier, A. Nash, M. Nation, N.R. Nattermann, T. Naumann, T. Navarro, G. Nderitu, S.K. Neal, H.A. Nebot, E. Nechaeva, P. Negri, A. Negri, G. Nelson, A. Nelson, T.K. Nemecek, S. Nemethy, P. Nepomuceno, A.A. Nessi, M. Neubauer, M.S. Neusiedl, A. Neves, R.M. Nevski, P. Newcomer, F.M. Nickerson, R.B. Nicolaidou, R. Nicolas, L. Nicoletti, G. Nicquevert, B. Niedercorn, F. Nielsen, J. Nikiforov, A. Nikolaev, K. Nikolic-Audit, I. Nikolopoulos, K. Nilsen, H. Nilsson, P. Nisati, A. Nishiyama, T. Nisius, R. Nodulman, L. Nomachi, M. Nomidis, I. Nordberg, M. Nordkvist, B. Notz, D. Novakova, J. Nozaki, M. Nožička, M. Nugent, I.M. Nuncio-Quiroz, A.-E. Hanninger, G.N. Nunnemann, T. Nurse, E. O'Neil, D.C. O'Shea, V. Oakham, F.G. Oberlack, H. Ochi, A. Oda, S. Odaka, S. Odier, J. Ogren, H. Oh, A. Oh, S.H. Ohm, C.C. Ohshima, T. Ohshita, H. Ohsugi, T. Okada, S. Okawa, H. Okumura, Y. Okuyama, T. Olchevski, A.G. Oliveira, M. Damazio, D.O. Garcia, E.O. Olivito, D. Olszewski, A. Olszowska, J. Omachi, C. Onofre, A. Onyisi, P.U.E. Oram, C.J. Oreglia, M.J. Oren, Y. Orestano, D. Orlov, I. Barrera, C.O. Orr, R.S. Ortega, E.O. Osculati, B. Ospanov, R. Osuna, C. Ottersbach, J.P. Ould-Saada, F. Ouraou, A. Ouyang, Q. Owen, M. Owen, S. Oyarzun, A. Ozcan, V.E. Ozone, K. Ozturk, N. Pages, A.P. Aranda, C.P. Paganis, E. Pahl, C. Paige, F. Pajchel, K. Palestini, S. Pallin, D. Palma, A. Palmer, J.D. Pan, Y.B. Panagiotopoulou, E. Panes, B. Panikashvili, N. Panitkin, S. Pantea, D. Panuskova, M. Paolone, V. Papadopoulou, T.D. Park, S.J. Park, W. Parker, M.A. Parodi, F. Parsons, J.A. Parzefall, U. Pasqualucci, E. Passeri, A. Pastore, F. Pastore, F. Pásztor, G. Pataraia, S. 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Robinson, M. Robson, A. Rocha de Lima, J.G. Roda, C. Dos Santos, D.R. Rodriguez, D. Garcia, Y.R. Roe, S. Røhne, O. Rojo, V. Rolli, S. Romaniouk, A. Romanov, V.M. Romeo, G. Maltrana, D.R. Roos, L. Ros, E. Rosati, S. Rosenbaum, G.A. Rosselet, L. Rossetti, V. Rossi, L.P. Rotaru, M. Rothberg, J. Rousseau, D. Royon, C.R. Rozanov, A. Rozen, Y. Ruan, X. Ruckert, B. Ruckstuhl, N. Rud, V.I. Rudolph, G. Rühr, F. Ruggieri, F. Ruiz-Martinez, A. Rumyantsev, L. Rurikova, Z. Rusakovich, N.A. Rutherfoord, J.P. Ruwiedel, C. Ruzicka, P. Ryabov, Y.F. Ryan, P. Rybkin, G. Rzaeva, S. Saavedra, A.F. Sadrozinski, H.F.-W. Sadykov, R. Tehrani, F.S. Sakamoto, H. Salamanna, G. Salamon, A. Saleem, M.S. Salihagic, D. Salnikov, A. Salt, J. Ferrando, B.M.S. Salvatore, D. Salvatore, F. Salvucci, A. Salzburger, A. Sampsonidis, D. Samset, B.H. Sandaker, H. Sander, H.G. Sanders, M.P. Sandhoff, M. Sandhu, P. Sandstroem, R. Sandvoss, S. Sankey, D.P.C. Sanny, B. Sansoni, A. Rios, C.S. Santoni, C. Santonico, R. Saraiva, J.G. Sarangi, T. Sarkisyan-Grinbaum, E. Sarri, F. Sasaki, O. Sasao, N. Satsounkevitch, I. Sauvage, G. Savard, P. Savine, A.Y. Savinov, V. Sawyer, L. Saxon, D.H. Says, L.P. Sbarra, C. Sbrizzi, A. Scannicchio, D.A. Schaarschmidt, J. Schacht, P. Schäfer, U. Schaetzel, S. Schaffer, A.C. Schaile, D. Schamberger, R.D. Schamov, A.G. Scharf, V. Schegelsky, V.A. Scheirich, D. Schernau, M. Scherzer, M.I. Schiavi, C. Schieck, J. Schioppa, M. Schlenker, S. Schmidt, E. Schmieden, K. Schmitt, C. Schmitz, M. Schönig, A. Schott, M. Schouten, D. Schovancova, J. Schram, M. Schreiner, A. Schroeder, C. Schroer, N. Schroers, M. Schultes, J. Schultz-Coulon, H.-C. Schumacher, J.W. Schumacher, M. Schumm, B.A. Schune, P. Schwanenberger, C. Schwartzman, A. Schwemling, P. Schwienhorst, R. Schwierz, R. Schwindling, J. Scott, W.G. Searcy, J. Sedykh, E. Segura, E. Seidel, S.C. Seiden, A. Seifert, F. Seixas, J.M. Sekhniaidze, G. Seliverstov, D.M. Sellden, B. Semprini-Cesari, N. Serfon, C. Serin, L. Seuster, R. Severini, H. Sevior, M.E. Sfyrla, A. Shabalina, E. Shamim, M. Shan, L.Y. Shank, J.T. Shao, Q.T. Shapiro, M. Shatalov, P.B. Shaw, K. Sherman, D. Sherwood, P. Shibata, A. Shimojima, M. Shin, T. Shmeleva, A. Shochet, M.J. Shupe, M.A. Sicho, P. Sidoti, A. Siegert, F. Siegrist, J. Sijacki, D. Silbert, O. Silva, J. Silver, Y. Silverstein, D. Silverstein, S.B. Simak, V. Simic, L. Simion, S. Simmons, B. Simonyan, M. Sinervo, P. Sinev, N.B. Sipica, V. Siragusa, G. Sisakyan, A.N. Sivoklokov, S.Y. Sjoelin, J. Sjursen, T.B. Skovpen, K. Skubic, P. Slater, M. Slavicek, T. Sliwa, K. Sloper, J. Smakhtin, V. Smirnov, S.Y. Smirnov, Y. Smirnova, L.N. Smirnova, O. Smith, B.C. Smith, D. Smith, K.M. Smizanska, M. Smolek, K. Snesarev, A.A. Snow, S.W. Snow, J. Snuverink, J. Snyder, S. Soares, M. Sobie, R. Sodomka, J. Soffer, A. Solans, C.A. Solar, M. Solc, J. Camillocci, E.S. Solodkov, A.A. Solovyanov, O.V. Sondericker, J. Sopko, V. Sopko, B. Sosebee, M. Soukharev, A. Spagnolo, S. Spanò, F. Spighi, R. Spigo, G. Spila, F. Spiwoks, R. Spousta, M. Spreitzer, T. Spurlock, B. Denis, R.D.S. Stahl, T. Stahlman, J. Stamen, R. Stancu, S.N. Stanecka, E. Stanek, R.W. Stanescu, C. Stapnes, S. Starchenko, E.A. Stark, J. Staroba, P. Starovoitov, P. Stastny, J. Stavina, P. Steele, G. Steinbach, P. Steinberg, P. Stekl, I. Stelzer, B. Stelzer, H.J. Stelzer-Chilton, O. Stenzel, H. Stevenson, K. Stewart, G.A. Stockton, M.C. Stoerig, K. Stoicea, G. Stonjek, S. Strachota, P. Stradling, A.R. Straessner, A. Strandberg, J. Strandberg, S. Strandlie, A. Strauss, M. Strizenec, P. Ströhmer, R. Strom, D.M. Stroynowski, R. Strube, J. Stugu, B. Sturm, P. Soh, D.A. Su, D. Sugaya, Y. Sugimoto, T. Suhr, C. Suk, M. Sulin, V.V. Sultansoy, S. Sumida, T. Sun, X.H. Sundermann, J.E. Suruliz, K. Sushkov, S. Susinno, G. Sutton, M.R. Suzuki, T. Suzuki, Y. Sykora, I. Sykora, T. Szymocha, T. Sánchez, J. Ta, D. Tackmann, K. Taffard, A. Tafirout, R. Taga, A. Takahashi, Y. Takai, H. Takashima, R. Takeda, H. Takeshita, T. Talby, M. Talyshev, A. Tamsett, M.C. Tanaka, J. Tanaka, R. Tanaka, S. Tanaka, S. Tapprogge, S. Tardif, D. Tarem, S. Tarrade, F. Tartarelli, G.F. Tas, P. Tasevsky, M. Tassi, E. Tatarkhanov, M. Taylor, C. Taylor, F.E. Taylor, G.N. Taylor, R.P. Taylor, W. Teixeira-Dias, P. Kate, H.T. Teng, P.K. Tennenbaum-Katan, Y.D. Terada, S. Terashi, K. Terron, J. Terwort, M. Testa, M. Teuscher, R.J. Therhaag, J. Thioye, M. Thoma, S. Thomas, J.P. Thompson, E.N. Thompson, P.D. Thompson, P.D. Thompson, R.J. Thompson, A.S. Thomson, E. Thun, R.P. Tic, T. Tikhomirov, V.O. Tikhonov, Y.A. Tipton, P. Aires Viegas, F.J.T. Tisserant, S. Toczek, B. Todorov, T. Todorova-Nova, S. Toggerson, B. Tojo, J. Tokár, S. Tokushuku, K. Tollefson, K. Tomasek, L. Tomasek, M. Tomoto, M. Tompkins, L. Toms, K. Tonoyan, A. Topfel, C. Topilin, N.D. Torchiani, I. Torrence, E. Pastor, E.T. Toth, J. Touchard, F. Tovey, D.R. Trefzger, T. Tremblet, L. Tricoli, A. Trigger, I.M. Trincaz-Duvoid, S. Trinh, T.N. Tripiana, M.F. Triplett, N. Trischuk, W. Trivedi, A. Trocmé, B. Troncon, C. Trzupek, A. Tsarouchas, C. Tseng, J.C.-L. Tsiakiris, M. Tsiareshka, P.V. Tsionou, D. Tsipolitis, G. Tsiskaridze, V. Tskhadadze, E.G. Tsukerman, I.I. Tsulaia, V. Tsung, J.-W. Tsuno, S. Tsybychev, D. Tuggle, J.M. Turecek, D. Cakir, I.T. Turlay, E. Tuts, P.M. Twomey, M.S. Tylmad, M. Tyndel, M. Uchida, K. Ueda, I. Ueno, R. Ugland, M. Uhlenbrock, M. Uhrmacher, M. Ukegawa, F. Unal, G. Undrus, A. Unel, G. Unno, Y. Urbaniec, D. Urkovsky, E. Urquijo, P. Urrejola, P. Usai, G. Uslenghi, M. Vacavant, L. Vacek, V. Vachon, B. Vahsen, S. Valente, P. Valentinetti, S. Valkar, S. Gallego, E.V. Vallecorsa, S. Ferrer, J.A.V. van Berg, R. van der Graaf, H. van der Kraaij, E. van der Poel, E. van der Ster, D. van Eldik, N. van Gemmeren, P. van Kesteren, Z. van Vulpen, I. Vandelli, W. Vaniachine, A. Vankov, P. Vannucci, F. Vari, R. Varnes, E.W. Varouchas, D. Vartapetian, A. Varvell, K.E. Vasilyeva, L. Vassilakopoulos, V.I. Vazeille, F. Vellidis, C. Veloso, F. Veneziano, S. Ventura, A. Ventura, D. Venturi, M. Venturi, N. Vercesi, V. Verducci, M. Verkerke, W. Vermeulen, J.C. Vetterli, M.C. Vichou, I. Vickey, T. Viehhauser, G.H.A. Villa, M. Villani, E.G. Perez, M.V. Vilucchi, E. Vincter, M.G. Vinek, E. Vinogradov, V.B. Viret, S. Virzi, J. Vitale, A. Vitells, O. Vivarelli, I. Vaque, F.V. Vlachos, S. Vlasak, M. Vlasov, N. Vogel, A. Vokac, P. Volpi, M. von der Schmitt, H. von Loeben, J. von Radziewski, H. von Toerne, E. Vorobel, V. Vorwerk, V. Vos, M. Voss, R. Voss, T.T. Vossebeld, J.H. Vranjes, N. Milosavljevic, M.V. Vrba, V. Vreeswijk, M. Anh, T.V. Vudragovic, D. Vuillermet, R. Vukotic, I. Wagner, P. Walbersloh, J. Walder, J. Walker, R. Walkowiak, W. Wall, R. Wang, C. Wang, H. Wang, J. Wang, S.M. Warburton, A. Ward, C.P. Warsinsky, M. Wastie, R. Watkins, P.M. Watson, A.T. Watson, M.F. Watts, G. Watts, S. Waugh, A.T. Waugh, B.M. Weber, M.D. Weber, M. Weber, M.S. Weber, P. Weidberg, A.R. Weingarten, J. Weiser, C. Wellenstein, H. Wells, P.S. Wenaus, T. Wendler, S. Wengler, T. Wenig, S. Wermes, N. Werner, M. Werner, P. Werth, M. Werthenbach, U. Wessels, M. Whalen, K. White, A. White, M.J. White, S. Whitehead, S.R. Whiteson, D. Whittington, D. Wicek, F. Wicke, D. Wickens, F.J. Wiedenmann, W. Wielers, M. Wienemann, P. Wiglesworth, C. Wiik, L.A.M. Wildauer, A. Wildt, M.A. Wilkens, H.G. Williams, E. Williams, H.H. Willocq, S. Wilson, J.A. Wilson, M.G. Wilson, A. Wingerter-Seez, I. Winklmeier, F. Wittgen, M. Wolter, M.W. Wolters, H. Wosiek, B.K. Wotschack, J. Woudstra, M.J. Wraight, K. Wright, C. Wright, D. Wrona, B. Wu, S.L. Wu, X. Wulf, E. Wynne, B.M. Xaplanteris, L. Xella, S. Xie, S. Xu, D. Xu, N. Yamada, M. Yamamoto, A. Yamamoto, K. Yamamoto, S. Yamamura, T. Yamaoka, J. Yamazaki, T. Yamazaki, Y. Yan, Z. Yang, H. Yang, U.K. Yang, Z. Yao, W.-M. Yao, Y. Yasu, Y. Ye, J. Ye, S. Yilmaz, M. Yoosoofmiya, R. Yorita, K. Yoshida, R. Young, C. Youssef, S.P. Yu, D. Yu, J. Yuan, L. Yurkewicz, A. Zaidan, R. Zaitsev, A.M. Zajacova, Z. Zambrano, V. Zanello, L. Zaytsev, A. Zeitnitz, C. Zeller, M. Zemla, A. Zendler, C. Zenin, O. Zenis, T. Zenonos, Z. Zenz, S. Zerwas, D. della Porta, G.Z. Zhan, Z. Zhang, H. Zhang, J. Zhang, Q. Zhang, X. Zhao, L. Zhao, T. Zhao, Z. Zhemchugov, A. Zhong, J. Zhou, B. Zhou, N. Zhou, Y. Zhu, C.G. Zhu, H. Zhu, Y. Zhuang, X. Zhuravlov, V. Zimmermann, R. Zimmermann, S. Zimmermann, S. Ziolkowski, M. Živković, L. Zobernig, G. Zoccoli, A. zur Nedden, M. Zutshi, V.

Subjects
Physics::Instrumentation and Detectors
Abstract

The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7. 6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22. 1±0. 9 μm and a relative momentum resolution σp/p=(4. 83±0. 16)×10-4 GeV-1×pT have been measured for high momentum tracks. © 2010 CERN for the benefit of the ATLAS collaboration.

Published
2010

15. [Pandemic influenza A H1N1 2009 flu during pregnancy: Epidemiology, diagnosis and management]

Author

O, Picone, O, Ami, C, Vauloup-Fellous, V, Martinez, M, Guillet, C, Dupont-Bernabé, A-C, Donnadieu, C, Trichot, M-V, Senat, H, Fernandez, and R, Frydman

Subjects
Influenza A Virus, H1N1 Subtype, Oseltamivir, Pregnancy, Nasopharynx, Influenza, Human, Humans, Female, Zanamivir, France, Pregnancy Complications, Infectious, Antiviral Agents, Disease Outbreaks
Abstract

Pandemic influenza A H1N1 2009 is a benign disease when infecting healthy adults, but it can lead to severe consequences in pregnant woman, for the fetus or its mother. The incidence of the disease is increasing strongly, and health authorities estimate that one third of the world population might be infected before the end of the winter. Diagnosis of infection with influenza virus H1N1 is suspected when a patient presents with the association of symptoms of the respiratory tract like sore throat, cough, or dyspnea, with general signs like fever, myalgias, or exhaustion. Diagnosis confirmation is obtained with nasopharyngeal swab and virus detection with molecular biology. This flu can lead to severe consequences for the pregnant woman and fetus. For this reason, it is advisable to treat pregnant women systematically by oseltamivir or zanamivir, and to treat preventively the pregnant woman in case of close contact with a suspected or confirmed infected person. Even if the management of influenza A H1N1 2009 infection during pregnancy relies on family physicians and gynecologists, every physician having in charge such cases should regularly update his knowledge regarding the evolution of the recommendations for the pandemic.

Published
2009

16. [Detection of cephalopelvic disproportion using a virtual reality model: a feasibility study of three cases]

Author

O, Ami, P, Chabrot, K, Jardon, D, Rocas, V, Delmas, L, Boyer, and G, Mage

Subjects
Adult, Imaging, Three-Dimensional, Pregnancy, Prenatal Diagnosis, Feasibility Studies, Humans, Cephalopelvic Disproportion, Computer Simulation, Female, Pelvimetry, Magnetic Resonance Imaging, Software
Abstract

Routine daily practice shows that successful vaginal delivery for women with suspected narrow pelvis or large fetus remains possible. We present a computer software for the detection of fetopelvic disproportion based on 3D vectorial reconstructions of the fetal head and maternal pelvis with simulation of head passage through the pelvis for collision detection. Three delivery simulations were generated from MR pelvimetry data in two patients, one with narrow pelvis and the other with macrosomic fetus. Based on the simulation, fetus size in both cases was appropriate for the pelvic size, but delivery simulation for the macrosomic fetus concluded that vaginal delivery was mechanically impossible. Further evaluation of this promising software on a larger patient population is necessary.

Published
2009

17. [3D modeling in the field of morphology: methods, interest and results]

Author

J F, Uhl, O, Plaisant, O, Ami, and V, Delmas

Subjects
Models, Anatomic, Leg, Image Processing, Computer-Assisted, Morphogenesis, Embryonic Development, Humans, Computer Simulation, Tomography, X-Ray Computed
Abstract

The aim of this paper is to show the major role played by the new computerized imaging tools available today in the fields of morphology and anatomy. For anatomical studies or educational purpose, they enhance the classical techniques. The 3D reconstruction, already used in daily clinical practice, will be the basis for computation of validated volumetric protocols enhancing our diagnosis and prognosis means. It is also a fantastic educational tool: the interactivity makes it simple, efficient, attractive and easily accessible and diffusable. For the research, mathematical modeling of embryogenesis and morphogenesis using finite elements method will open new ways for biomecanics and a dynamic quantification approach.

Published
2006

19. L’elastographie statique : principes, developpements et applications

Author

O. Ami and C. Bricout

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging
Abstract

Objectifs Connaitre le principe technique de l’elastosonographie statique HI-RTE. Connaitre les principaux developpements de l’imagerie par elastoso-nographie statique et ses applications. Savoir realiser une elastosonographie par voie endovaginale et connaitre ses indications. Savoir juger la qualite de realisation d’une elastosonographie statique HI-RTE par voie endovaginale. Messages a retenir Le mode HI-RTE est un mode d’imagerie non invasif. L’elastosonographie est un complement diagnostique utile dans de multiples indications en gynecologie. L’elastosonographie permet une bonne differenciation des myomes uterins par rapport au myometre sain. Le degre de maturation cervicale peut etre apprecie en elastosonographie statique HI-RTE avant l’accouchement. Resume L’elastosonographie en temps reel (HI-RTE, Hitachi MS) est la premiere technique echographique qui montre en temps reel l’elasticite relative des tissus, grâce a un codage couleur. La mise au point de processeurs ultrarapides et d’une methode d’auto correlation combinee permet la detection temporelle des deplacements 2D des tissus, ainsi que l’analyse de l’amplitude et de la phase des signaux ultrasonores. Cette technique ne necessitant que des cycles de legeres pressions et decompressions des tissus lors de l’examen, autorise l’utilisation de l’elastographie (HI-RTE) sur de nombreuses sondes differentes (endocavitaires, lineaires, convexes, laparoscopiques ou echo-endoscopiques), permettant d’etudier les proprietes elastiques des tissus. De multiples indications d’utilisation de l’elastosonogra-phie endovaginale apparaissent deja dans le domaine de la gynecologie obstetrique (myomes uterins dont le module d’elasticite est tres superieur a celui du myometre sain, modifications cervicales au cours de la grossesse…).

Published
2009

20. OP30.13: Transvaginal real time elastosonography for uterine fibroids diagnosis and mapping

Author

M. Mabille, J. M. Levaillant, Olivier Picone, Xavier Deffieux, René Frydman, O. Ami, D. Musset, and F. Lamazou

Subjects
medicine.medical_specialty, Reproductive Medicine, Radiological and Ultrasound Technology, business.industry, Uterine fibroids, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Radiology, business, medicine.disease
Published
2009

21. Beckwith-Wiedemann syndrome in association with posterior hypoplasia of the cerebellar vermis

Author

J. M. Levaillant, O. Ami, I. Netchine, C. Bui, A.E. Mas, M. V. Senat, René Frydman, and Olivier Picone

Subjects
Pathology, medicine.medical_specialty, Omphalocele, medicine.diagnostic_test, business.industry, Beckwith–Wiedemann syndrome, Obstetrics and Gynecology, Prenatal diagnosis, medicine.disease, Cisterna magna, Hypoplasia, Macroglossia, medicine, Amniocentesis, Cerebellar vermis, medicine.symptom, business, Genetics (clinical)
Abstract

We present the case of a 28-year-old woman with an unremarkable medical and obstetrical history. Both parents are Caucasian; the couple is not consanguineous and have already had a healthy child after a normal pregnancy. The first ultrasound scan at 13 weeks was considered normal. Second trimester serum markers suggested a chromosomal abnormality risk of 1/108, leading to another diagnostic ultrasound at 18 weeks, which identified an omphalocele. Karyotype analysis of the fluid sampled by amniocentesis was normal, 46, XX. The 22-week ultrasound confirmed the omphalocele. The latter contained only the small bowel, and its collar measured 20 mm. The liver was in a normal position. In addition, the fourth ventricle was open, communicating with the cisterna magna through a large canal, with hypoplasia of the posterior vermis (Figure 1). No facial anomaly was noticed. A multidisciplinary group of staff explained the poor prognosis of these morphological abnormalities to the couple, whose request that the pregnancy be terminated was approved in accordance with French law. At 25 weeks, a 1040-g female fetus (95th percentile for term) was delivered. The subsequent pathology examination confirmed the features we had observed and also showed craniofacial dysmorphy involving macroglossia, large ears with indentation of the left lobe, and a marked under-eye crease, together with organomegaly. The placenta was hypertrophic and dysmature, with heterogeneous villi. Microscopic analysis highlighted cytomegaly of the extravillous placental trophoblast cells and the fetal adrenal cortex. The association of these anomalies led to a diagnosis of Beckwith–Wiedemann syndrome (BWS). Subsequent

Published
2009

22. Intérêt de la reconstruction 3D et de la modélisation en anatomie

Author

V. Delmas, Odile Plaisant, O. Ami, C. Gillot, and J.G. Uhl

Subjects
Anatomy
Abstract

Objectifs Montrer l’interet et les nombreuses applications de la reconstruction 3D en anatomie utilisant les fonctions de la realite virtuelle. Resultats Ces progres interessent principalement trois grands domaines en anatomie. 1. L’anatomie « clinique » c’est a dire les investigations radiologiques des patients 2. L’enseignement de l’anatomie : l’interactivite associee au realisme des reconstructions 3D et a la possibilite de vision en relief en font un outil pedagogique hors pair, attractif et evolutif, autorisant de plus le tele-enseignement sur internet. 3. La recherche en anatomie : la reconstruction 3D permet en effet une analyse quantitative dans l’espace tridimensionnel des donnees anatomiques, c’est a dire des etudes morphometriques precises des organes et des structures anatomiques, grâce a une modelisation mathematique par elements finis Conclusion La modelisation 3D est un outil pedagogique inegalable en anatomie. De plus, elle ouvre de nouvelles voies de recherche permettant des etudes dynamiques quantifiees de l’embyogenese et de l’organogenese. Enfin, dans un futur proche elle va s’enrichir de l’imagerie fonctionnelle et de l’imagerie a l’echelle cellulaire.

Published
2005

23. Anatomie tridimensionnelle du muscle releveur de l’anus au repos

Author

E.A. Cabanis, O. Ami, Jean-François Uhl, M.T. Iba-Zizen, A. Benezit, R. Pessis, Vincent Delmas, and J. Lopater

Subjects
Anatomy
Abstract

But Le but de ce travail est d’analyser la forme et la disposition des deux faisceaux du muscle elevateur de l’anus au repos (faisceaux pubococcygien et iliococcygien), ainsi que les rapports anatomiques de ce muscle dans le pelvis. Materiel et methodes Les coupes IRM ont ete obtenues a partir de trois femmes en bonne sante, nulligestes, et sans antecedent de pathologie pelvienne (de 19 a 22 ans). - Les coupes retenues pour l’etude sont des coupes coronales du pelvis au repos, ponderees en T2. - Une reconstruction tridimensionnelle des muscles, visceres, et structures osseuses du pelvis a ete faite. Des calculs de distance, de surface et de volume ont ensuite ete menes a partir de cette reconstruction. Resultats 1) Le muscle elevateur de l’anus. Son faisceau pubococcygien est medial ; il est epais et etroit, dans un plan longitudinal. Son faisceau iliococcygien est lateral ; il est mince et large ; il est en dome. 2) Ses rapports anatomiques. Les rapports directs du pubococcygien sont constitues par la vessie et l’uretre, le vagin, et la jonction anorectale. Le muscle elevateur de l’anus constitue la limite inferieure du pelvis. Conclusion Ces donnees in vivo confirment les donnees obtenues sur sujets anatomiques. La reconstruction tridimensionnelle permet une meilleure visualisation du muscle releveur de l’anus et de ses rapports et une etude morphometrique. Elle fournit des donnees pour un eventuel travail de correlation entre la morphometrie de ce muscle et les pathologies d’incontinence et de prolapsus.

Published
2004

24. Imagerie 3D du système veineux : investigation des patients et outil de recherche

Author

Vincent Delmas, Odile Plaisant, C. Gillot, O. Ami, and Jean-François Uhl

Subjects
Anatomy
Abstract

Objectifs Realiser une dissection anatomique virtuelle du systeme veineux grâce a une reconstruction 3D a partir des donnees du phlebo-scanner. Materiel et methodes L’exploration par scanner helicoidal multi-barette avec injection permet de realiser une modelisation interactive apres reconstructions 3D. Des logiciels dedies de volume rendering (VRT) et de surface rendering (SSR) sont utilises. Resultats L’anatomie complexe des variations du systeme veineux est ainsi decrite avec precision. Conclusion Cette nouvelle application de la realite virtuelle est utile aussi bien pour le bilan pre-operatoire des patients variqueux complexes que comme outil pedagogique et de recherche en anatomie veineuse.

Published
2004

25. RP-WS-1 Apport de l’IRM de diffusion avec tracking de fibres pour l’exploration d’anomalies cerebrales in utero

Author

J. De Laveaucoupet, Sophie Prevot, M. V. Senat, O. Ami, M. Mabille, D. Musset, A.E. Mas, and R. Frydman

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging
Abstract

Objectifs Evaluer la faisabilite et l’interet du tracking de fibres par IRM de diffusion sur le cerveau fœtal in utero. Materiels et methodes Les cerveaux de deux fœtus presentant des malformations justifiant une interruption medicale de grossesse (malformation cardiaque complexe pour le premier et agenesie du corps calleux pour le second), ont ete etudies in utero en IRM sur un appareil Siemens Avanto de 1,5 Tesla. Aux sequences morphologiques habituelles (T2 HASTE et Tl GE) a ete ajoutee une sequence DTI permettant de realiser le tracking des fibres de la region calleuse. L’agencement des fibres des deux cerveaux a ensuite ete compare. Le diagnostic a ete confirme par anatomopathologie. Resultats Le cerveau du premier fœtus, avec un corps calleux intact, a montre de nombreux faisceaux de fibres connectant les deux hemispheres, et une disposition courbe des prolongements nerveux. Le cerveau du second fœtus, atteint d’agenesie complete du corps calleux, n’a montre aucune connexion entre les deux hemispheres et une reorganisation plus lineaire et plus angulaire des fibres. Conclusion La detection in utero de l’orientation des fibres cerebrales fœtales est possible et permet de preciser les modifications de l’architecture cerebrale d’origine malformative.

Published
2009

26. AGF-WS-11 Apport de l’elastographie temps reel au cours de l’echographie endovaginale pour myomes uterins

Author

O. Ami, D. Musset, J. M. Levaillant, F. Lamazou, M. Mabille, and René Frydman

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging
Abstract

Objectifs Le but de cette etude etait d’evaluer un nouvel outil de cartographie et de diagnostic des fibromes uterins par analyse du module d’elasticite tissulaire au cours d’une echographie endovaginale. Materiels et methodes L’elastographie temps reel par voie endovaginale a ete evaluee chez 10 patientes beneficiant d’une echographie preoperatoire pour fibrome uterin. L’appareil utilise etait un Hitachi EUB-8500HV equipe du logiciel d’elastographie Hi-RTE et d’une sonde endovaginale de 5,9 Mhz EUP-V53W. Les reglages utilises sont frequence en mode T-Elasto-H, rejection du bruit de valeur 5-6 et d’images de valeur 4, dynamique de base de valeur 3, lissage de valeur 3, persistance de valeur 6-7, cadence d’image en reglage M ou H. Un controle positif par anatomopathologie a confirme la nature myomateuse pure des lesions observees. Resultats Le module d’elasticite mesure pour les fibromes etait en moyenne de 11 fois plus rigide que celui du myometre sain (p = 0,017). Tous les myomes etaient bien reperes sur la cartographie en fausse couleurs, et leurs limites etaient plus precisement visibles qu’en mode B conventionnel. La distance entre les myomes et la cavite endometriale a pu etre precisee dans tous les cas. Conclusion L’elastographie en temps reel ameliore la visibilite des contours des myomes uterins.

Published
2009

27. P05.03: Antenatal neuronal fiber tracking with diffusion tensor MRI in humans

Author

Olivier Picone, René Frydman, M. Mabille, D. Musset, A.E. Mas, O. Ami, M. V. Senat, and Sophie Prevot

Subjects
Univariate analysis, Pregnancy, Radiological and Ultrasound Technology, business.industry, Cost effectiveness, Obstetrics and Gynecology, Gestational age, General Medicine, medicine.disease, Reproductive Medicine, medicine, Radiology, Nuclear Medicine and imaging, Ventricular zone, Nuclear medicine, business, Fetal medicine, Diffusion MRI, Tractography
Abstract

The primary aim of this study was to calculate, based on a mathematically modelled decision tree the cost effectiveness of the RM as an intervention for improving fetal medicine specialist’s decisions. Methods: 106 cases of fCNS were prospectively followed up until either termination of pregnancy (TOP) or postnatal follow up (PF). All of them underwent dedicated ultrasonographic (US) assessment and MR, at least once during prenatal evaluation. Neurological postnatal outcome and anatomo-pathology records were registered as gold standards. Positive and negative likelihood ratios (LR) were calculated for four specific regions: posterior fosa (PF), ventricular zone (VZ), cortex and subcortical region (CSC) and middle line (ML). After refinement of univariate analysis, a discriminative likelihood ratio (LR) was calculated for every region and technique, based on direct and indirect cost and calculated post-test probability a Markov’s chain was designed to modelate the real effectiveness of each test. Results: Table 1 summarizes LR results for region and technique, based on post test probabilities and costs, the probability of improving diagnosis with MR before 22 weeks is 15% for PF, 18,5% for VZ, 11% for CSC, 23% for ML, once modified the model for gestational age, the probability at 33 weeks increases to 53%, 78%, 65% and 42% respectively.

Published
2009

28. OP16.03: Virtual delivery with MRI

Author

Pascal Chabrot, D. Lemery, Louis Boyer, O. Ami, G. Mage, and B. Rabischong

Subjects
medicine.medical_specialty, Reproductive Medicine, Radiological and Ultrasound Technology, business.industry, medicine, Obstetrics and Gynecology, Radiology, Nuclear Medicine and imaging, Medical physics, General Medicine, business
Published
2009

29. P38.08: Dehydrated hereditary stomatocytosis showing variable expressivity: Report of two cases and review of the literature

Author

A. Nguyen, L. Garçon, O. Ami, M. V. Senat, René Frydman, and Olivier Picone

Subjects
medicine.medical_specialty, Polyhydramnios, Radiological and Ultrasound Technology, business.industry, medicine.medical_treatment, Obstetrics and Gynecology, General Medicine, medicine.disease, Pericardial effusion, Surgery, Benign tumor, Reproductive Medicine, Pericardiocentesis, medicine, Dehydrated hereditary stomatocytosis, Radiology, Nuclear Medicine and imaging, Immature teratoma, Teratoma, business, Venous return curve
Abstract

ensuing weeks the mass increased in size, causing compression of venous return with increase in pericardial effusion, development of cariomegaly with A-V valves regurgitation, polyhydramnios, and ascites. Pericardiocentesis was performed. By 34 wks the mass had grown to 43 × 44 mm with worsening cardiac failure; the baby was delivered by C/S followed by neonatal cardiac surgery (Fig 1b), but the baby died on the 5th day of life. Pathology analysis of tumor tissue showed invasive immature teratoma (Fig 1b-c). Discussion: Pericardial teratoma is generally a benign tumor, with good outcome after neonatal cardiac surgery. In this case the fastgrowing tumor proved to be a lethal invasive immature teratoma.

Published
2008

30. OP07.01: Fertility after uterine fibroid embolization: A series of 54 pregnancies in France

Author

O. Ami, J. H. Ravina, J. J. Merland, N. Ciraru, A. Aymard, and J. M. Bourret

Subjects
Gynecology, medicine.medical_specialty, Radiological and Ultrasound Technology, Obstetrics, business.industry, media_common.quotation_subject, Obstetrics and Gynecology, Fertility, General Medicine, Reproductive Medicine, Uterine fibroid embolization, medicine, Radiology, Nuclear Medicine and imaging, business, media_common
Published
2008

32. Evaluation des resultats morphologiques IRM apres embolisation arterielle uterine pour fibromes (EFU) : 27 patientes

Author

E. Lipiecka, E. Dumousset, S. Poujol, O. Ami, Jean-Marc Garcier, N. Mazet, Louis Boyer, S. Ughetto, and Anne Ravel

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging
Abstract

Objectifs Evaluer en IRM le retentissement morphologique apres embolisation a titre curatif des arteres uterines. Materiels et methodes Vingt-sept patientes (âge moyen : 42,75 ans, 51-23), affectees de fibromes symptomatiques (syndrome de masse et/ou saignements) ont ete explorees avant, puis 3 et 12 mois apres embolisation arterielle uterine, en utilisant la methode conventionnelle de l’ellipsoide et une methode de mesure volumique originale par maillage vectoriel apres contourage manuel de l’uterus et des fibromes. Une etude evolutive en fonction de la semiologie IRM initiale a ete effectuee. Resultats Toutes les patientes ont vu leur symptomatologie s’ameliorer, apres un suivi moyen de 5,5 mois (3-12 mois). Les resultats des deux methodes de mesure n’etaient pas significativement differents. Avant embolisation le volume moyen des fibromes dominants etait de 122,7 cm3 (380.8-6.6). La reduction moyenne du volume des fibromes etait : 40,2 % a 3 mois, 57,2 % a 1 an, et respectivement 21,3 % et 41,9 % pour le volume uterin. Nous observions une reduction de volume plus importante pour les fibromes en hypersignal T2, mais aucune correlation significative entre resultats IRM et amelioration clinique. Conclusion L’IRM, determinante pour les indications, objective la regression volumique apres embolisation sans donner de facteur morphologique predictif.

Published
2006

34. Imagerie 3D du système veineux des membres inférieurs : outil d’investigation et de recherche anatomique

Author

C. Gillot, Jean-François Uhl, O. Ami, and Odile Plaisant

Subjects
Anatomy
Abstract

Objectifs Realiser une visualisation 3D ainsi qu’une dissection anatomique virtuelle du systeme veineux grâce a une reconstruction 3D a partir des donnees du phlebo-scanner. Materiel et methodes l’exploration par scanner helicoidal multi-barette avec injection permet de realiser une modelisation interactive apres reconstructions 3D. Des logiciels dedies de volume rendering (VRT) et de surface rendering (SSR) sont utilises. Resultats L’anatomie complexe du systeme veineux est ainsi definie avec precision grâce aux modifications de transparence de la peau et des muscles. Ceci permet d’identifier les veines profondes, les veines musculaires et leurs connexions avec le systeme des perforantes. Cette analyse est particulierement utile dans le cas des malformations vasculaires congenitales et les recidives variqueuses post-operatoires, en particulier du creux poplite. Conclusion Cette nouvelle application de la realite virtuelle est utile aussi bien pour le bilan pre-operatoire des patients variqueux complexes que comme outil pedagogique et de recherche en anatomie veineuse.

Published
2005

35. Reconstruction 3D dynamique du muscle levator ani à partir de l’IRM : évaluation volumique

Author

A.E. Cabanis, V. Delmas, M.T. Iba-Zizen, O. Ami, J. Lopater, and Jean-François Uhl

Subjects
Anatomy
Abstract

Objectif Le but de ce travail est d’evaluer la dynamique des 2 faisceaux du muscle levator ani : iliococcygien et puborectal et de preciser leur anatomie fonctionnelle par une modelisation 3D. Material et methode Une acquisition IRM en coronal ponderee en T2 avec turbo spin echo a ete realisee chez 3 jeunes femmes nullipares en bonne sante (moyenne d’âge, 20,6 ans). Des coupes ont ete reealisees en decubitus en position de repos, retenue et poussee avec Valsalva. Des modeles 3D ont ete reconstruits par segmentation vectorielle en utilisant le logiciel Surfdriver version 3.5. en utilisant des reperes osseux fixes. Les volumes et la morphologie des muscles Iliococcygien, puborectal et sphincter externe de l’anus ont ete mesures dans les 3 positions. La volumetrie et des animations avec morphing ont ete calcules avec le logiciel 3D studiomax. Resultats Le volume moyen du muscle Iliococcygien a ete evalue a 14,4 cm3. Celui du pubo-rectal a 17,5 cm3. Les changements de volume de ces muscles dans les 3 postures n’ont pas montre de difference significative. Conclusion Les animations 3D avec morphing permettent une apprehension fine de l’anatomie fonctionnelle. Les calculs volumetriques sont simples et reproductibles.

Published
2005

36. Imagerie par resonance magnetique fonctionnelle fœtale : oxymetrie du fœtus a membranes fermees au cours de la souffrance fœtale aigue chez l’animal

Author

Jean-Yves Boire, P. Truong, X. Tran, G. Dumont, M. Canis, Pascal Chabrot, O. Ami, Jean-Marc Garcier, Louis Boyer, Gérard Mage, and A.L. Cherprenet

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging
Abstract

Objectifs Le manque de critere precoce et fiable de detection de la souffrance fœtale est responsable de l’augmentation necessaire mais non souhaitee du taux de cesariennes. Nous presentons une technique de surveillance de l’oxymetrie sanguine fœtale par IRM en T2* durant l’hypoxie aigue chez le porcelet et le fœtus de brebis. Materiels et methodes L’imagerie T2* hepatique du foie maternel et fœtal de 8 cochons et 3 brebis gravides a ete effectuee sous un champ magnetique de 1,5T avant et apres provocation artificielle d’hypoxie fœtale en utilisant une anesthesie generale et une substitution de gaz inhales ou une apnee. L’etude de l’oxymetrie a ete realisee en dehors du travail et a membranes intactes. Codage du signal sur 256 tons de gris hexadecimaux. Resultats L’analyse des sequences T2* a montre un changement significatif du signal, correle au degre de l’hypoxie de maniere hyperbolique sur les sequences natives (Signal moyen de 151 a 46,25 pour une saturation arterielle en oxygene de 100 % a 20 % chez la mere). Le traitement en pourcentage du pic de bolus (PBP, Percentage of Bolus Peak) permet d’obtenir une courbe de tendances en cas de desaturation brusque. Conclusion La modification du signal T2* est positivement correlee a l’hypoxie fœtale et reflete le taux de desoxy-hemoglobine du fœtus. La comparaison entre le signal hepatique maternel et fœtal permet de deduire le niveau d’oxymetrie du fœtus. Cette technique peut etre utile pour detecter precocement la souffrance fœtale et accroitre ainsi la securite obstetricale.

Published
2005

37. Morphologie dynamique du muscle levator ani en IRM par reconstruction vectorielle et animation paramétrique

Author

A. Benezit, J. Lopater, E.A. Cabanis, R. Pessis, Jean-François Uhl, Vincent Delmas, M.T. Iba-Zizen, and O. Ami

Subjects
Anatomy
Abstract

But Le but de cette etude etait d’analyser la contraction des differents faisceaux du muscle levator ani : iliococcygien et puborectal. Materiel et Methode Une IRM a ete realisee chez 3 femmes en bonne sante, continentes et nulligestes (âge, 20,6 ; de 19 a 23 ans). Des coupes coronales ponderees T2 du bassin ont ete effectuees en position couchee au repos, en retenue et en poussee (manœuvre de Valsalva). Les modeles vectoriels tridimensionnels ont ete obtenus par segmentation manuelle a partir des images sources, et ont ete cales sur des reperes anatomiques osseux. La dynamique des muscles (iliococcygien, puborectal, sphincter strie, obturateurs internes), des os (sacrum, coccyx, os iliaques) et des visceres (uterus, rectum et vessie) a ete etudiee a l’aide d’un logiciel d’animation parametrique. Resultats Les changements dynamiques de morphologie du muscle levator ani decrivent son anatomie fonctionnelle. Les changements dynamiques de morphologie des rapports de ce muscle au sein du petit bassin decrivent son influence dans la statique pelvienne. Conclusion L’animation des variations dynamiques de morphologie du muscle levator ani permet une meilleure comprehension de l’anatomie fonctionnelle.

Published
2004

38. Anatomie dynamique tridimensionnelle du muscle releveur de l’anus entre poussée et retenue

Author

R. Pessis, Vincent Delmas, J. Lopater, A. Benezit, E.A. Cabanis, O. Ami, M.T. Iba-Zizen, and Jean-François Uhl

Subjects
Anatomy
Abstract

Objectif Le but de cette etude est de decrire la dynamique des deux faisceaux iliococcygien et pubococcygien du muscle elevateur de l’anus entre poussee et retenue. Materiel et methodes L’etude a ete realisee sur trois femmes âgees entre 19 et 22 ans, nulligeste et sans antecedents de pathologie pelvienne. Des coupes IRM dans un plan perpendiculaire au detroit inferieur, ponderees en T2 ont ete acquises successivement au repos, en retenue puis en poussee. Chaque structure du pelvis a ete reconstruite apres contourage manuel avec un logiciel 3D, a savoir les os iliaques, les femurs, le sacrum et le coccyx pour les os ; l’uterus, la vessie et le rectum pour les visceres ; l’obturateur interne et les faisceaux pubococcygien et iliococcygien du muscle elevateur de l’anus pour les muscles. Une sequence dynamique du petit bassin en trois dimensions a ainsi ete obtenue. Resultats Le faisceau iliococcygien : En retenue : le faisceau iliococcygien a une morphologie en dome convexe vers le haut, accentuee en comparaison avec la position repos. En poussee : la convexite s’attenue, le faisceau devient presque horizontal. Cette description contraste avec celle habituellement presentee a partir de dissections qui montre un faisceau iliococcygien en entonnoir a concavite dirigee vers le haut. Le faisceau pubococcygien : Entre la poussee et la retenue, le faisceau s’epaissit et retrecie la fente urogenitale. Les changements anatomiques du muscle releveur de l’anus entre poussee et retenue montrent l’influence de ce muscle dans la statique pelvienne. Conclusion L’etude dynamique de ce muscle permet de comprendre son anatomie fonctionnelle et de dissocier la fonction de chacun des faisceaux. Ceci doit trouver son application dans la comprehension du prolapsus et de l’incontinence.

Published
2004

39. Modélisation 3D des variantes du canal et de l’artère cystique

Author

Vincent Delmas, O. Ami, and Jean-François Uhl

Subjects
Anatomy
Abstract

Objectif Modelisation 3D des variantes du canal et de l’artere cystique, dont les variations anatomiques representent autant de pieges pour le chirurgien digestif. Materiel et methodes Logiciel de modelisation vectorielle 3D, textures issues d’images coelioscopiques, moteur de rendu 3D temps reel en « bump mapping ». Resultats L’anatomie complexe de cette region peut etre presentee de maniere demonstrative par les modeles 3D a partir d’observations chez l’humain : 6 variantes du canal cystique et 9 variantes de l’artere cystique sont decrites parmi les plus frequentes. Les moteurs de rendus temps reel permettent de projeter et de manipuler des organes virtuels instantanement (zoom, translation, rotation, animation). Conclusion La modelisation 3D vectorielle des variantes anatomiques de l’artere et du canal cystique permet une presentation optimale de l’anatomie et offre des perspectives interessantes pour la realite augmentee en chirurgie. Les modeles ainsi crees peuvent egalement servir en simulation chirurgicale.

Published
2004

40. Anatomie 3D vectorielle du canal et de l’artère cystique : enjeux de la cholecystectomie coelioscopique

Author

Vincent Delmas, Jean-François Uhl, and O. Ami

Subjects
Anatomy
Abstract

Objectifs Modelisation des variantes du canal et de l’artere cystique, dont les variations anatomiques representent autant de pieges pour le chirurgien digestif. Materiel et methodes Logiciel de modelisation vectorielle 3D Studio Max, textures issues d’images cœlioscopiques, moteur de rendu 3D temps reel en bump mapping. Resultats L’anatomie complexe de cette region est decrite de maniere precise et demonstrative par les modeles 3D a partir d’observations chez l’homme : 6 variantes du canal cystique, et 9 variantes de l’artere cystique parmi les plus frequentes. Conclusion La modelisation 3D vectorielle des variantes anatomiques de l’artere et du canal cystique permet d’optimiser l’apprentissage de l’anatomie, prelude indispensable a la realisation d’actes moins invasifs mais comportant des risques propres. Les modeles ainsi crees pourront servir en chirurgie virtuelle pour simuler une situation clinique et participer a l’optimisation d’algorithmes de reconstruction vectoriels a partir d’imagerie par resonance magnetique nucleaire.

Published
2004

42. MUSCULOSKELETAL DISORDERS AMONG MUNICIPAL SOLID WASTE WORKERS

Author

R. Mehrdad, M. Majlessi-Nasr, O. Aminian, and S. A. Sharifian F. Malekahmadi

Subjects
Solid waste workers, Medicine (General), R5-920
Abstract

Waste collection is a necessary activity all around the world and the removal of municipal solid waste is a job associated with a variety of biological, chemical, mechanical, physical, and psychosocial hazards. In our country, like many developing countries, municipal solid waste is collected manually and collection of household waste is also a job which requires repeated heavy physical activity such as lifting, carrying, pulling, and pushing. We performed this study to evaluate musculoskeletal disorders among municipal solid waste workers. We designed a cross sectional study. Our survey instrument for measurement of musculoskeletal symptoms was adapted from the Standardized Nordic Questionnaire that translated into Farsi language. A total of 65% (n=142) of participants reported that they had been troubled with musculoskeletal symptoms in one or more of the 9 defined body regions during the last 12 months. Prevalence of symptoms in low back, knees, shoulders, upper back and neck were 45, 29, 24, 23 and 22% respectively. Foreign workers reported more musculoskeletal symptoms in all body parts than Iranian workers. The differences between prevalence of symptoms between two groups were significant in all parts of body except knees. The study found that solid waste workers have more musculoskeletal disorders than general population. Meanwhile these symptoms were more common among foreign workers. The risk of disease was increased with the increasing years of working as solid waste worker and smoking. We didn't find relationship between musculoskeletal disorders and education or marriage status of workers.

Published
2008

43. Covariant second variation for first order Lagrangians on fibered manifolds II: generalized curvature and Bianchi identities

Author

O. AMICI, B. CASCIARO, and M. FRANCAVIGLIA

Subjects
second variation, generalized curvature tensorfields, bianchi identities, Mathematics, QA1-939
Abstract

The notion of generalized curvature structures ensuing from the second variation of a (first–order) Lagrangian is extensively discussed. It is shown that generalized curvature structures satisfy appropriate (generalized) Bianchi identities. Formulae applicable to curvature Lagrangians are developed in great detail. Examples are taken from the theory of generalized harmonic Lagrangians.

Published
1996

44. Childbirth simulation to assess cephalopelvic disproportion and chances for failed labor in a French population.

Author

Ami O, Maran JC, Cohen A, Hendler I, Zabukovek E, and Boyer L

Subjects
Pregnancy, Humans, Female, Retrospective Studies, Delivery, Obstetric methods, Parturition, Cesarean Section, Cephalopelvic Disproportion epidemiology
Abstract

Reducing failed labor and emergency cesarean section (CS) rates is an important goal. A childbirth simulation tool (PREDIBIRTH software and SIM37 platform) that evaluates a 5-min magnetic resonance imaging (MRI) assessment performed at 37 weeks of gestation was developed to enhance the consulting obstetrician's ability to predict the optimal delivery mode. We aimed to determine the potential value of this childbirth simulation tool in facilitating the selection of an optimal delivery mode for both mother and infant. A retrospective cohort study was performed on all patients referred by their obstetricians to our level 2 maternity radiology department between December 15, 2015 and November 15, 2016, to undergo MRI pelvimetry at approximately 37 weeks of gestation. The childbirth simulation software was employed to predict the optimal delivery mode based on the assessment of cephalopelvic disproportion. The prediction was compared with the actual outcome for each case. Including childbirth simulations in the decision-making process had the potential to reduce emergency CSs, inappropriately scheduled CSs, and instrumental vaginal deliveries by up to 30.1%, 20.7%, and 20.0%, respectively. Although the use of the simulation tool might not have affected the overall CS rate, consideration of predicted birthing outcomes has the potential to improve the allocation between scheduled CS and trial of labor. The routine use of childbirth simulation software as a clinical support tool when choosing the optimal delivery mode for singleton pregnancies with a cephalic presentation could reduce the number of emergency CSs, insufficiently justified CSs, and instrumental deliveries., (© 2023. The Author(s).)

Published
2023
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45. Using Magnetic Resonance Imaging During Childbirth to Demonstrate Fetal Head Moldability and Brain Compression: Prospective Cohort Study.

Author

Ami O, Maran JC, Musset D, Dubray C, Mage G, and Boyer L

Abstract

Background: Childbirth is a physiological process with significant medical risk, given that neurological impairment due to the birthing process can occur at any time. Improvements in risk assessment and anticipatory interventions are constantly needed; however, the birthing process is difficult to assess using simple imaging technology because the maternal bony pelvis and fetal skeleton interfere with visualizing the soft tissues. Magnetic resonance imaging (MRI) is a noninvasive technique with no ionizing radiation that can monitor the biomechanics of the birthing process. However, the effective use of this modality requires teamwork and the implementation of the appropriate safeguards to achieve appropriate safety levels., Objective: This study describes a clinically effective and safe method to perform real-time MRI during the birthing process. We reported the experience of our team as part of the IMAGINAITRE study protocol (France), which aimed to better understand the biomechanics of childbirth., Methods: A total of 27 pregnant women were examined with 3D MRI sequences before going into labor using a 1-Tesla open-field MRI. Of these 27 patients, 7 (26%) subsequently had another set of 3D MRI sequences during the second stage of labor. Volumes of 2D images were transformed into finite element 3D reconstructions. Polygonal meshes for each part of the fetal body were used to study fetal head moldability and brain compression., Results: All 7 observed babies showed a sugarloaf skull deformity and brain compression at the middle strait. The fetus showing the greatest degree of molding and brain shape deformation weighed 4525 g and was born spontaneously but also presented with a low Apgar score. In this case, observable brain shape deformation demonstrated that brain compression had occurred, and it was not necessarily well tolerated by the fetus. Depending on fetal head moldability, these observations suggest that cephalopelvic disproportion can result in either obstructed labor or major fetal head molding with brain compression., Conclusions: This study suggests the presence of skull moldability as a confounding factor explaining why MRI, even with the best precision to measure radiological landmarks, fails to accurately predict the modality of childbirth. This introduces the fetal head compliance criterion as a way to better understand cephalopelvic disproportion mechanisms in obstetrics. MRI might be the best imaging technology by which to explore all combined aspects of cephalopelvic disproportion and achieve a better understanding of the underlying mechanisms of fetal head molding and moldability., (©Olivier Ami, Jean-Christophe Maran, Dominique Musset, Claude Dubray, Gérard Mage, Louis Boyer. Originally published in JMIR Formative Research (https://formative.jmir.org), 30.11.2022.)

Published
2022
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46. Double-layered purse string uterine suture compared with single-layer continuous uterine suture: A randomized Controlled trial.

Author

Dimassi K, Ami O, Merai R, Velemir L, Simon B, Fauck D, and Triki A

Subjects
Adult, Female, Humans, Operative Time, Pregnancy, Prospective Studies, Cesarean Section methods, Cicatrix prevention & control, Suture Techniques instrumentation, Uterus surgery
Abstract

Background: With the aim of preventing cesarean scar defects, we introduced a new technique involving a purse string uterine suture. To date, this uterine suture technique has not been formally evaluated. The objective of the study was to test the hypothesis that compared to single layer continuous uterine suture (SLCUS), a double layered purse string uterine suture (PSUS) significantly reduces cesarean scar defect (CSD) rates, without increasing the perioperative maternal morbidity., Methods: A prospective randomized study. Primary outcome was the rate of CSD. 100 patients were enrolled in 2 groups according to the uterine suture technique. A hysterosonography was performed by the same senior obstetrician blinded to the uterine suture technique 6 months after surgery .Operative time and calculated blood loss (CBL) were used for the short time analysis. Uterine and CSD measurements were used for the mid time analysis., Results: Despite a longer operative time with PSUS (7.17 ± 2.31 min Vs. 6.31 ± 3.04 min, p = 0.028; p <10‾³); there was no significant difference in terms of CBL (520 ± 58 with PSUS vs. 536 ± 50 ml, p = 0.724). There was a significant decrease in the rate of CSD with PSUS: 6.66% Vs.40% with SLUCS; p<0.001. Moreover, SLUCS was the leading risk factor for CSD: adjusted OR=6; 95% CI [0-1], p<10‾³)., Conclusion: Compared to single layer continuous suture, double layered purse stringuterine suture significantly reduces cesarean scar defect rates, without increasing the perioperative maternal morbidity., Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests, (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)

Published
2022
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47. The extraperitoneal French AmbUlatory cesarean section technique leads to improved pain scores and a faster maternal autonomy compared with the intraperitoneal Misgav Ladach technique: A prospective randomized controlled trial.

Author

Dimassi K, Halouani A, Kammoun A, Ami O, Simon B, Velemir L, Fauck D, and Triki A

Subjects
Adult, Female, Humans, Pregnancy, Prospective Studies, Cesarean Section, Pain, Postoperative prevention & control, Postoperative Period
Abstract

Objective: To determine whether the French AmbUlatory Cesarean Section (FAUCS) technique reduces postoperative pain and promotes maternal autonomy compared with the Misgav Ladach cesarean section (MLCS) technique in elective conditions., Study Design: One hundred pregnant women were randomly, but in a non-blinded manner, assigned to undergo FAUCS or MLCS. The primary outcome was a postoperative mean pain score (PMPS), and secondary outcomes were a combined pain/medication score, time to regain autonomy, surgical duration, calculated blood loss, surgical complications, and neonatal outcome., Results: Women in the FAUCS group experienced less pain than those in the MLCS group (PMPS = 1.87 [1.04-2.41] vs. 2.93 [2.46-3.75], respectively; p < 0.001). Six hours after surgery, the combined pain/medication score for FAUCS patients was 33% lower than that for MLCS patients (p < 0.001). FAUCS patients more rapidly regained autonomy, with 94% reaching autonomy within 12 h vs. 4% of MLCS patients (p < 0.001). There were no differences in maternal surgical or neonatal complications between groups., Conclusions: Our results indicate that FAUCS can reduce postoperative pain and accelerate recovery, suggesting that this technique might be superior to MLCS and should be more widely used. One potentially key difference between FAUCS and MLCS is that MLCS includes 100 mcg spinal morphine anesthesia in addition to the same anesthesia used by FAUCS. Any interpretation of apparent differences must take the presence/absence of morphine into account., Competing Interests: The authors have read the journal's policy, and the authors of this study have the following competing interests to share: OA, BS, and DF work for Ramsay Health Care. However, none of the authors receive a salary for their work, nor did they receive any funding for this research. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.

Published
2021
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48. French ambulatory cesarean: Mother and newborn safety.

Author

Dimassi K, Ami O, Fauck D, Simon B, Velemir L, and Triki A

Subjects
Adult, Blood Loss, Surgical statistics & numerical data, Cesarean Section statistics & numerical data, Female, Humans, Infant, Newborn, Operative Time, Pain, Postoperative etiology, Pregnancy, Prospective Studies, Tunisia, Cesarean Section methods
Abstract

Objective: To evaluate mother and newborn child safety after French ambulatory cesarean (FAUCS)., Methods: Prospective comparative cohort study in Tunisia (January-June 2018). Pregnant women indicated for primary or repeat cesarean at term underwent FAUCS or Misgav Ladach cesarean (MLC). Surgical outcomes, overall morbidity, and maternal autonomy during recovery were compared., Results: Among 112 deliveries, 60 were performed by FAUCS and 52 by MLC. FAUCS was feasible in all cases; surgeons achieved a completely extraperitoneal approach in 39 (65.0%) cases. The main difficulty experienced was fetal extraction. Longer operative procedures were recorded in the FAUCS group; however, women in the FAUCS group reported lower pain scores (3 [2-5] vs 4 [3.7-5], P<0.001) and were more likely to decline analgesics (10 [17.0%] vs 0 [0%], P<0.001). They experienced greater autonomy during recovery (median [interquartile range] time to standing, 2 [1.0-2.5] vs 12.8 [8.9-17.9] hours, P<0.001; time to full meal, 4 [3-6[ vs 26.5 [21-31] hours, P<0.001; effective time to hospital discharge, 1 [1, 2] vs 2 [2, 3] days; P<0.001)., Conclusion: Implementation of the FAUCS technique was safe and successful, and improved maternal condition after cesarean. These short-term results need long-term validation by randomized trials., (© 2019 International Federation of Gynecology and Obstetrics.)

Published
2020
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49. Three-dimensional magnetic resonance imaging of fetal head molding and brain shape changes during the second stage of labor.

Author

Ami O, Maran JC, Gabor P, Whitacre EB, Musset D, Dubray C, Mage G, and Boyer L

Subjects
Adult, Brain anatomy & histology, Brain diagnostic imaging, Female, Humans, Organ Size, Pregnancy, Young Adult, Fetus anatomy & histology, Fetus diagnostic imaging, Head anatomy & histology, Head diagnostic imaging, Imaging, Three-Dimensional, Labor Stage, Second, Magnetic Resonance Imaging
Abstract

To demonstrate and describe fetal head molding and brain shape changes during delivery, we used three-dimensional (3D) magnetic resonance imaging (MRI) and 3D finite element mesh reconstructions to compare the fetal head between prelabor and the second stage of labor. A total of 27 pregnant women were examined with 3D MRI sequences before going into labor using a 1 Tesla open field MRI. Seven of these patients subsequently had another set of 3D MRI sequences during the second stage of labor. Volumes of 2D images were transformed into finite element 3D reconstructions. Polygonal meshes for each part of the fetal body were used to study fetal head molding and brain shape changes. Varying degrees of fetal head molding were present in the infants of all seven patients studied during the second phase of labor compared with the images acquired before birth. The cranial deformation, however, was no longer observed after birth in five out of the seven newborns, whose post-natal cranial parameters were identical to those measured before delivery. The changing shape of the fetal brain following the molding process and constraints on the brain tissue were observed in all the fetuses. Of the three fetuses presenting the greatest molding of the skull bones and brain shape deformation, two were delivered by cesarean-section (one after a forceps failure and one for engagement default), while the fetus presenting with the greatest skull molding and brain shape deformation was born physiologically. This study demonstrates the value of 3D MRI study with 3D finite element mesh reconstruction during the second stage of labor to reveal how the fetal brain is impacted by the molding of the cranial bones. Fetal head molding was systematically observed when the fetal head was engaged between the superior pelvic strait and the middle brim., Competing Interests: The authors have declared that no competing interests exist.

Published
2019
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