1. Enhanced wound healing by topical application of ointment containing a low concentration of povidone-iodine
- Author
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O Mitani, Hitoshi Mizutani, I Kurokawa, M Ikeda, Esteban C. Gabazza, and A Nishikawa
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Nursing (miscellaneous) ,Petrolatum ,Wound size ,chemistry.chemical_element ,Pharmacology ,Iodine ,Ointments ,03 medical and health sciences ,0302 clinical medicine ,Skin Ulcer ,Animals ,Medicine ,Povidone-Iodine ,White petrolatum ,Volume concentration ,Earlobe ,Wound Healing ,integumentary system ,business.industry ,Dermatology ,Rats ,Hairless ,Disease Models, Animal ,medicine.drug_formulation_ingredient ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,030220 oncology & carcinogenesis ,Anti-Infective Agents, Local ,Fundamentals and skills ,Rabbits ,business ,Wound healing - Abstract
Objective: To investigate the effect of a novel topical wound-healing agent, low-concentration povidone-iodine ointment (LPIO) with a hydrophobic white petrolatum-rich base on skin-wound models in rats and rabbits. Method: The therapeutic efficacy of topically applied LPIO was compared to that of standard-concentration povidone-iodine ointment (SPIO) and non-treatment control, using a full-thickness skin-wound model in 24 hairless rats and a full-thickness skin-defect model in rabbit earlobes. The animals were kept under standardised conditions at the Central Research Laboratory of Maruishi Pharmaceutical Co. Ltd. (Osaka, Japan). Therapeutic efficacy was evaluated based on macroscopic wound-size reduction, as well as histopathological and immuno-histochemical examinations. Results: LPIO enhanced wound healing in rat full-thickness skin ulcers, reducing wound size and inflammation, when compared with that in SPIO and non-treatment control. LPIO also markedly improved wound healing in rabbit earlobe ulcers by significantly improving re-epithelialisation, compared with that in SPIO. Conclusion: The results of this study suggest that LPIO is a useful topical therapy for ulcerative lesions.
- Published
- 2016