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Enhanced wound healing by topical application of ointment containing a low concentration of povidone-iodine
- Source :
- Journal of Wound Care. 25:521-529
- Publication Year :
- 2016
- Publisher :
- Mark Allen Group, 2016.
-
Abstract
- Objective: To investigate the effect of a novel topical wound-healing agent, low-concentration povidone-iodine ointment (LPIO) with a hydrophobic white petrolatum-rich base on skin-wound models in rats and rabbits. Method: The therapeutic efficacy of topically applied LPIO was compared to that of standard-concentration povidone-iodine ointment (SPIO) and non-treatment control, using a full-thickness skin-wound model in 24 hairless rats and a full-thickness skin-defect model in rabbit earlobes. The animals were kept under standardised conditions at the Central Research Laboratory of Maruishi Pharmaceutical Co. Ltd. (Osaka, Japan). Therapeutic efficacy was evaluated based on macroscopic wound-size reduction, as well as histopathological and immuno-histochemical examinations. Results: LPIO enhanced wound healing in rat full-thickness skin ulcers, reducing wound size and inflammation, when compared with that in SPIO and non-treatment control. LPIO also markedly improved wound healing in rabbit earlobe ulcers by significantly improving re-epithelialisation, compared with that in SPIO. Conclusion: The results of this study suggest that LPIO is a useful topical therapy for ulcerative lesions.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Nursing (miscellaneous)
Petrolatum
Wound size
chemistry.chemical_element
Pharmacology
Iodine
Ointments
03 medical and health sciences
0302 clinical medicine
Skin Ulcer
Animals
Medicine
Povidone-Iodine
White petrolatum
Volume concentration
Earlobe
Wound Healing
integumentary system
business.industry
Dermatology
Rats
Hairless
Disease Models, Animal
medicine.drug_formulation_ingredient
030104 developmental biology
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Anti-Infective Agents, Local
Fundamentals and skills
Rabbits
business
Wound healing
Subjects
Details
- ISSN :
- 20522916 and 09690700
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of Wound Care
- Accession number :
- edsair.doi.dedup.....1e245bcf1ebef2493349658f9058062d