Search

Background: Children with Down syndrome have speech and language difficulties that are disproportionate to their overall intellectual ability and relative strengths in the use of gesture. Shared book reading between parents and their children provides an effective context in which language development can be facilitated. However, children with Down syndrome often take a passive role in shared book reading and the use of key word signing (KWS) as a shared book reading technique has never been investigated. Aims: This study aimed to compare children with Down syndrome's participation and use of KWS across two methods of shared book reading -- one in which a book had key-word sign prompts embedded (signed condition) and the other in which a book was read as normal (unsigned condition). Measures of child and parent communicative behaviour were taken in each condition to establish if differences emerged. Methods & Procedures: A total of 36 children with Down syndrome (aged between 18 and 61 months) and their mothers took part in the study. Parent-child dyads were videoed at home reading two books, one in a signed and one in an unsigned condition. Child measures included total number of signs produced in each condition and levels of attention and initiation as measured by the Pivotal Behaviour Rating Scale. Parent measures included total number of utterances, mean length of utterance (MLU) in morphemes and vocabulary diversity (VOCD). Parental measures were transcribed using the Codes for Human Analysis Transcripts (CHAT) software and analysed by the Computerised Language Analysis software (CLAN). Contrasts in outcomes between the signed and unsigned conditions were estimated using Poisson and linear mixed-effects models, determined by the type of data. Outcomes & Results: Results showed that children attempted to sign significantly more in the signed than unsigned condition, as well as showing significant increases in their levels of attention and initiation. There was also a significant increase in the total number of utterances used by parents in the signed versus unsigned condition and a decrease in MLU. VOCD was similar in both conditions. Conclusions & Implications: This study shows that the simple act of embedding key word signs into commercially available books, during shared book reading between parents and young children with Down syndrome, positively affects children's participation (initiation and attention) and use of KWS. The use of KWS as a core shared book reading technique may therefore be a fruitful avenue to facilitate growth in the language abilities of young children with Down syndrome.

Purpose: Parent-child interaction therapy refers to a number of interventions mediated by trained parents to treat developmental difficulties, including speech, language, and communication. Understanding the experiences of parents who take part in parent-child interaction therapy is a key aspect of determining how this intervention can be implemented successfully. However, to date, there has been limited work on synthesizing parental views of this intervention. Method: We used qualitative evidence synthesis that involved searching the literature for qualitative studies addressing the experiences and perceptions of parent-child interaction therapy for parents of preschool children with communication difficulties. We identified 27 studies (from 32 publications) and synthesized the data using thematic synthesis. We appraised the quality of included studies using Critical Appraisal Skills Programme (CASP) and assessed our confidence in the review findings using GRADE Confidence in the Evidence from Reviews of Qualitative research (CERQual). Results: At the beginning of this intervention, parents may have competing demands and varied expectations about the intervention. Their engagement is facilitated when the intervention is tailored to their individual family, their preferences for learning, and when they have a trusting relationship with the clinician. At the end of the intervention, although most parents perceive an improvement in their child's communication and feel empowered to facilitate this, they have concerns about their child's future needs. Conclusions: It is important that clinicians explore parents' readiness for this intervention by discussing their needs and preferences openly, and that they facilitate their engagement through a supportive relationship. They also need to consider how parents will transition out of the intervention and continue to support their child's language development.

Background: Speech intelligibility is a global indicator of the severity of a speech problem. It is a measure that has been used frequently in research and clinical assessment of speech. Previous studies have shown that factors, such as measurement method and listener experience, can influence speech intelligibility scores. However, these factors of speech intelligibility assessment have not yet been investigated in people with Down syndrome (DS). Aims: To compare the speech intelligibility scores in speakers with DS measured using two methods--orthographic transcription and visual analogue scale (VAS), by two groups of listeners, experienced listeners and naïve listeners. Also, to examine the relationship across the four sets of speech intelligibility scores by means of correlational analysis. Methods & Procedures: A total of 30 adolescents and adults with DS read or repeated 12 sentences from a standardized test of intelligibility for adults with dysarthria. Each sentence was saved as a separate sound file and the 360 sentences were divided to form eight sets of stimuli. A total of 32 adults (16 experienced and 16 naïve) served as listeners of speech intelligibility. Each listener heard a single set of sentences and independently estimated the level of intelligibility for each sentence using a VAS in one task and wrote down the words perceived (i.e., orthographic transcription) in another task. The order of the two tasks was counterbalanced across listeners and the tasks were completed at least 1 week apart. Outcomes & Results: Repeated-measures analysis of variance (ANOVA), confirmed by mixed-methods analysis, showed that the scores obtained using orthographic transcription were significantly higher than those obtained using VAS; and the experienced listeners' scores were significantly higher than the naïve listeners' scores. Spearman rank correlation analysis showed that the four sets of scores across all conditions were strongly positively correlated with each other. Conclusions & Implications: Listeners, both experienced and naïve, may judge speech in DS differently when using orthographic transcription versus VAS as the method of measurement. In addition, experienced listeners can judge speech intelligibility differently compared with listeners who are less exposed to unclear speech, which may not represent 'real-world' functional communicative ability. Speech and language therapists should be aware of the effect of these factors when measuring intelligibility scores and direct comparison of scores obtained using different procedures and by different groups of listeners is not recommended.

Assessing vocabulary knowledge is an important part of establishing language proficiency in bilingual children. The crosslinguistic lexical tasks (CLTs) provide a framework for testing vocabulary development in three-to-six year-olds using a standard procedure and comparable items for multiple languages. This study describes the development of the Irish CLTs to test receptive and expressive vocabulary for nouns and verbs. The test was then used in a pilot study to measure the vocabulary development in both Irish and English of 41 bilingual children attending Irish-immersion education in an Irish-speaking region of Ireland. The results showed that, as expected, children found lexical comprehension to be easier than production, and nouns easier than verbs. As a group, those from Irish dominant homes performed similarly on both the Irish and English versions of the CLTs, but those from bilingual and English-dominant homes performed significantly better on the English version. The amount of home-language exposure to Irish and English showed advantages on production tasks in each language. However, all groups performed relatively poorly on the production and comprehension of Irish verbs. We explore the findings in relation to the importance of language exposure in a minority language context. [ABSTRACT FROM AUTHOR]

Background: Few studies have explored the feasibility of online language interventions for young children with Down syndrome. Additionally, none have manipulated dose frequency or reported on the use of music as a medium through which language and sign can be learned. Purpose: The purpose of this study was to (a) examine the feasibility and acceptability of an online language through music intervention for young children (1-3;6 years) with Down syndrome and (b) compare effectiveness at two intervention dose frequencies. Method: The study was carried out in two phases using a mixed-methods design. Phase 1: Qualitative data were gathered from parents to examine feasibility when implementing a video-based language intervention. Phase 2: Seventy-six families participated in an online language intervention at home. Effectiveness was examined comparing two groups, randomly assigned to a high and low dose frequency. The Down Syndrome Education (DSE) checklists (combined) were the primary outcome measure. Process data were gathered to determine intervention acceptability in practice and to identify factors that would improve successful future implementation. Acceptability data were analyzed with reference to the theoretical framework of acceptability (Version 2). Results: Forty-three parents completed the Phase 1 scoping questionnaire, five of whom took part in focus groups. Once weekly morning sessions were indicated as the preferred scheduling choice. Phase 2 quantitative data were analyzed using beta regression adjusted for baseline scores and indicated no additional benefit to receiving the higher dose. However, exploratory interaction models suggested that the efficacy of the high-dose intervention was higher (than low-dose intervention) in participants with higher baseline DSE performance. Parents perceived the intervention to be effective and positive for the family. Conclusion: The results add to our knowledge of real-world effective online interventions and suggest that a critical minimum language level is required for children with Down syndrome to benefit optimally from a higher intervention dose frequency. [ABSTRACT FROM AUTHOR]

Purpose: Parent-child interaction therapy refers to a number of interventions mediated by trained parents to treat developmental difficulties, including speech, language, and communication. Understanding the experiences of parents who take part in parent-child interaction therapy is a key aspect of determining how this intervention can be implemented successfully. However, to date, there has been limited work on synthesizing parental views of this intervention. Method: We used qualitative evidence synthesis that involved searching the literature for qualitative studies addressing the experiences and perceptions of parent-child interaction therapy for parents of preschool children with communication difficulties. We identified 27 studies (from 32 publications) and synthesized the data using thematic synthesis. We appraised the quality of included studies using Critical Appraisal Skills Programme (CASP) and assessed our confidence in the review findings using GRADE Confidence in the Evidence from Reviews of Qualitative research (CERQual). Results: At the beginning of this intervention, parents may have competing demands and varied expectations about the intervention. Their engagement is facilitated when the intervention is tailored to their individual family, their preferences for learning, and when they have a trusting relationship with the clinician. At the end of the intervention, although most parents perceive an improvement in their child's communication and feel empowered to facilitate this, they have concerns about their child's future needs. Conclusions: It is important that clinicians explore parents' readiness for this intervention by discussing their needs and preferences openly, and that they facilitate their engagement through a supportive relationship. They also need to consider how parents will transition out of the intervention and continue to support their child's language development. Supplemental Material: https://doi.org/10.23641/asha. 14978454, Parents are integral to a child's early language development. We have known for many years that the amount of caregiver speech directed to young children is associated with better language [...]

Purpose: This study examines the expressive language and speech of twins, relative to singletons, at 3 and 5 years, with the aim of determining if a twinning effect occurs during this developmental period. The possibility of twins outgrowing a twinning effect was investigated. Method: A weighted population-based sample of 185 twins and 1,309 closely spaced singletons who participated in the Growing Up in Ireland study was analyzed. Their development was compared using a standardized expressive vocabulary assessment and parent interview at 3 and 5 years as well as teacher reports at 5 years. Causal steps mediation analyses were subsequently conducted to determine if gestation and birth weight mediated twin-singleton differences in expressive vocabulary development. Results: Twins' expressive vocabulary scores were slightly lower than those of singletons at 3 years, but there was no significant difference at 5 years. More parents of twins reported "a little" concern about their child's expressive language and speech skills at 3 years, although there was no significant twin--singleton difference 2 years later. Teachers' ratings of twins' and singletons' expressive language and speech skills at 5 years were comparable. Shorter gestations and lower birth weights mediated twins' lower expressive vocabulary scores at 3 years. Conclusions: A very small twinning effect on expressive vocabulary development exists at 3 years and is outgrown by 5 years. Twins born after shorter gestations or at a lower birth weight are at an increased risk of having less developed expressive vocabulary skills at 3 years.

This study investigated the role of language exposure in vocabulary acquisition in Irish, a threatened minority language in Ireland which is usually acquired with English in a bilingual context. Using a bilingual Irish-English adaptation of the MacArthur-Bates Communicative Development Inventories) [Fenson, L., V. A. Marchman, D. J. Thal, P. S. Dale, J. S. Reznick, and E. Bates. 2007. "The MacArthur-Bates Communicative Development Inventories." 2nd ed. Baltimore: Brookes], longitudinal parent report data were collected from 34 children (19 girls and 15 boys) at 4-monthly intervals, resulting in 61 data points between the ages of 17-36 months. Language exposure estimates indicated that while the caregivers "always" spoke Irish to the children, both languages were used in most households, with/among siblings and extended family. The children's vocabulary indicated that they were Irish-dominant in this age range, with more Irish words than English for all vocabulary categories. The analysis also showed no difference in Irish vocabulary scores between children who were "usually" exposed to Irish compared to those with lower exposure rates to Irish. However, there was a significant effect for caregivers' reported use of English on children's English scores. The results are discussed in terms of the language input needed to maintain an endangered language and factors to take into account for establishing good estimates of language exposure in a minority language context.

This paper compared the vocabulary size of a group of 250 bilinguals aged 24-36 months acquiring six different language pairs using an analogous tool, and attempted to identify factors that influence vocabulary sizes and ultimately place children at risk for language delay. Each research group used adaptations of the MacArthur-Bates Communicative Development Inventories: Words and Sentences and a specially designed developmental and language background questionnaire to gather information on risk factors for language impairment, demographic and language exposure variables. The results showed a wide range in vocabulary development which could be somewhat attributed to mothers' education status, parental concerns about language development and amount of exposure to the second language. We looked at those children performing below the 10th and above the 90th percentile to determine what factors were related to their vocabulary size. Features of the entire group of lower performing children were fewer than 50 words and the absence of two-word combinations by 24 months, lower levels of parental education and parental concerns about language development. The implications for identifying bilingual children at risk for language impairment as well as the language enrichment that might be needed for young bilinguals are outlined.

The expressive lexical skills of 53 Polish bilinguals aged 24-36 months living in the UK and Ireland were assessed using Polish and British English adaptations of the MacArthur-Bates Communicative Development Inventories. Polish vocabulary scores were compared to those of 53 Polish monolinguals matched for age, gender and parental education. The bilinguals were born to two Polish parents and mostly lived outside Poland since birth. Results showed substantial differences in Total Conceptual Vocabulary and single-language vocabulary scores between the groups. However, the groups did not differ on Total Vocabulary measures. In the bilingual sample, there were significant correlations between children's frequency of language use and their vocabulary scores in the same language. A negative correlation between children's frequency of English use and their Polish vocabulary scores was found. A complex pattern of factors relating to children's low performance in Polish emerged. Hierarchical multiple regression analyses showed that low birth weight, parental concern about language, maternal educational level as well as maternal frequency of Polish and English use contributed to explaining children's Polish vocabulary scores. Overall, results indicated the need for early additional support of the first language (L1) if long-term balanced bilingualism is to be attained.

Purpose: This study examines the expressive language and speech of twins, relative to singletons, at 3 and 5 years, with the aim of determining if a twinning effect occurs during this developmental period. The possibility of twins outgrowing a twinning effect was investigated. Method: A weighted population-based sample of 185 twins and 1,309 closely spaced singletons who participated in the Growing Up in Ireland study was analyzed. Their development was compared using a standardized expressive vocabulary assessment and parent interview at 3 and 5 years as well as teacher reports at 5 years. Causal steps mediation analyses were subsequently conducted to determine if gestation and birth weight mediated twin-singleton differences in expressive vocabulary development. Results: Twins' expressive vocabulary scores were slightly lower than those of singletons at 3 years, but there was no significant difference at 5 years. More parents of twins reported 'a little' concern about their child's expressive language and speech skills at 3 years, although there was no significant twin-singleton difference 2 years later. Teachers' ratings of twins' and singletons' expressive language and speech skills at 5 years were comparable. Shorter gestations and lower birth weights mediated twins' lower expressive vocabulary scores at 3 years. Conclusions: A very small twinning effect on expressive vocabulary development exists at 3 years and is outgrown by 5 years. Twins born after shorter gestations or at a lower birth weight are at an increased risk of having less developed expressive vocabulary skills at 3 years., Recent international growth of the twin population renews clinical interest in twin development and sharpens our need for contemporary twin research. Twin birth rates have almost doubled in America, Australia, [...]

Background: Children with Down syndrome have speech and language difficulties that are disproportionate to their overall intellectual ability and relative strengths in the use of gesture. Shared book reading between parents and their children provides an effective context in which language development can be facilitated. However, children with Down syndrome often take a passive role in shared book reading and the use of key word signing (KWS) as a shared book reading technique has never been investigated. Aims: This study aimed to compare children with Down syndrome's participation and use of KWS across two methods of shared book reading – one in which a book had key‐word sign prompts embedded (signed condition) and the other in which a book was read as normal (unsigned condition). Measures of child and parent communicative behaviour were taken in each condition to establish if differences emerged. Methods & Procedures: A total of 36 children with Down syndrome (aged between 18 and 61 months) and their mothers took part in the study. Parent–child dyads were videoed at home reading two books, one in a signed and one in an unsigned condition. Child measures included total number of signs produced in each condition and levels of attention and initiation as measured by the Pivotal Behaviour Rating Scale. Parent measures included total number of utterances, mean length of utterance (MLU) in morphemes and vocabulary diversity (VOCD). Parental measures were transcribed using the Codes for Human Analysis Transcripts (CHAT) software and analysed by the Computerised Language Analysis software (CLAN). Contrasts in outcomes between the signed and unsigned conditions were estimated using Poisson and linear mixed‐effects models, determined by the type of data. Outcomes & Results: Results showed that children attempted to sign significantly more in the signed than unsigned condition, as well as showing significant increases in their levels of attention and initiation. There was also a significant increase in the total number of utterances used by parents in the signed versus unsigned condition and a decrease in MLU. VOCD was similar in both conditions. Conclusions & Implications: This study shows that the simple act of embedding key word signs into commercially available books, during shared book reading between parents and young children with Down syndrome, positively affects children's participation (initiation and attention) and use of KWS. The use of KWS as a core shared book reading technique may therefore be a fruitful avenue to facilitate growth in the language abilities of young children with Down syndrome. What this paper adds: What is already known on this subject: Most children with Down syndrome have significant speech and language difficulties, with relative strengths in the use of gesture. Shared book reading is an activity reported to positively affect language. However, children with Down syndrome are reported to take a passive role in shared book reading and are therefore more dependent on their parents to use techniques that facilitate their levels of participation, in order to maximise potential benefits. To the best of our knowledge, the communicative effects of embedding key word signing (KWS) in shared book reading have never been examined with children with Down syndrome. What this paper adds to existing knowledge: This is the first study to investigate the communicative impact of parents embedding KWS in a shared book reading activity with their young children with Down syndrome. Our findings show that this relatively simple manipulation resulted in Increase in children's sign attempts.Increase in children's overall participation in shared book reading (indicated by levels of attention and initiation).Increase in the number of utterances produced by parents (primarily as a result of repetitions).Decrease in parental mean length of utterance. These findings suggest that embedding KWS in shared book reading is likely to facilitate increased language abilities in this cohort. What are the potential or actual clinical implications of this work?: Shared book reading is part of the daily routine for many parents and their children with Down syndrome. Integrating KWS is a relatively simple adaptation to this activity which is likely to enhance children's language skills. Therapists can encourage parents to do this at home to support work carried out at school and in a clinical setting. [ABSTRACT FROM AUTHOR]

Diagnosing specific language impairment (SLI) in monolingual children is a complex task, with some controversy regarding criteria. Diagnosis of SLI in bilinguals is made more complex by the lack of standardized assessments and poor understanding of clinical markers in languages other than English. There is an added complexity when one of the languages being acquired is an endangered one, where the domains of use and input are restricted, and where input is affected by convergence with the majority language. This article explores the challenge facing speech and language therapists and psychologists in diagnosing SLI in bilingual children acquiring Irish and English. Six speech and language therapists and four psychologists took part in semi-structured interviews exploring the impact of the bilingual environment, the nature of bilingual language impairment, current practices and the needs of these children. Thematic analysis was carried out and here three of the main themes emerging in the areas of assessment, the bilingual environment and characteristics of language impairment in this population are discussed. For assessment, an overriding theme was the requirement of standardized testing to secure additional educational and therapy resources for these children. However, because there are no standardized tests available in Irish, both professions end up translating existing English-based language and psychological assessments, using the norms provided to achieve standard scores. Both professions expressed strong dissatisfaction with this practice but saw little choice, given the Department of Education's approach to allocation of supports. Language impairment in Irish was characterized by lexical difficulties, particularly with verbs and prepositions, tense errors, and significant borrowing and code-switching with English. Other themes that emerged were the growing influence of English as the children became older, which affected both attitudes to the minority Irish language as well as the content and structure of the language itself. The implications for service provision for bilingual populations in general are outlined. (Contains 3 figures.)

Investigations into early vocabulary development, including the timing of the acquisition of nouns, verbs and closed-class words, have produced conflicting results, both within and across languages. Studying vocabulary development in Irish can contribute to this area, as it has potentially informative features such as a VSO word order, and semantically rich prepositions. This study used a parent report adapted for Irish, to measure vocabulary development longitudinally for children aged between 1 ; 04 and 3 ; 04. The findings indicated that the children learned closed-class words at relatively smaller vocabulary sizes compared to children acquiring other languages, and had a strong preference for nouns. (Contains 1 footnote.)

This study examined the impact of a training programme which aimed to support language-, literacy- and social-communication-promoting strategies for professionals working with children with language delay. Sixteen teachers, special needs assistants and therapists based in services for children with mild to severe learning difficulties attended workshops and took part in six video-feedback sessions from the Hanen "Learning Language and Loving It" Programme (Weitzman, 1992). Video analysis found that participants' language and social interaction skills significantly improved on most of the targeted skills. However, the majority of skills needed further development as indicated by a rating scale. There was also a significant improvement in how participants rated their skills in working with children with speech and language difficulties and in their attitudes towards their role in remediating speech and language difficulties. There was no significant change in their opinions towards collaborative working practices. The findings suggest that with appropriate training, allied education and health professionals can produce measurable changes in behaviour and attitudes towards implementing speech- and language-promoting strategies. (Contains 4 tables and 1 figure.)

Background: Understanding the relationship between preverbal skills and language development has important implications for identifying communication delay/disorders and for early childhood intervention. In the case of children with Down syndrome, it is well established that symbolic play is associated with the emergence of language. However, the exact nature of this relationship remains unclear, as many previous studies have addressed functional play and not actual symbolic play, which is felt to have stronger links to language development. The design of studies has also meant that adults may have inadvertently modeled the targeted behaviors, in which case it is unclear whether the children truly comprehend the symbolic acts that they produce. Aims: This study set out to investigate further symbolic functioning and language in children with Down syndrome by exploring truly symbolic play as opposed to functional play, as well as the understanding of a graded set of novel symbols. The aim was to find out whether the symbolic behaviors would be associated with each other and with language development or non-verbal cognition. It was hypothesized that symbolic functioning on a test of symbolic play and symbolic comprehension would be significantly correlated with each other and with language abilities as they all measure underlying skills in symbolic representation. It was hypothesized that symbolic skills and language would be less closely correlated with non-verbal abilities. Another goal was to study understanding of three types of symbols: gestures, miniatures and abstract symbols. It was hypothesized that gestures would be significantly easier to understand than miniatures or abstract symbols. Methods & Procedures: Twenty-one children with Down syndrome aged between 32 and 95 months were assessed on the Test of Pretend Play and a novel symbolic comprehension task as well as on standardized language and non-verbal tests. Correlational analysis was carried out to determine the relationship between the various tests, and the children were divided into three age categories to examine how the relationship changed with development. Analysis was also carried out on the children's performance across the gesture, miniature and symbolic subtests of the symbolic comprehension task. Outcomes & Results: When effects of chronological age were partialled out, symbolic play and symbolic comprehension were significantly correlated with each other and with expressive and receptive language, but not with non-verbal ability. The association between language and symbolic functioning was significantly stronger in the younger children, but these measures started to dissociate with increasing age and language development. The data support the proposition that language becomes more domain specific as a result of experience and development. The results from the symbolic comprehension experiment revealed that the children found gestures significantly easier to understand than miniatures or substitute objects used as abstract symbols to represent other objects. Conclusions: The findings indicate that tests of symbolic functioning offer valuable contributions to assessment with implications for intervention in children with Down syndrome and to the understanding of disorders of language and communication. (Contains 4 tables and 1 graph.)

Aims and objectives: The aim of this study was to develop and pilot a test of receptive vocabulary for bilingual Irish-English-speaking children, based on a model from Welsh. Design/Methodology/Approach: 310 typically developing children aged five, six and seven years took part. The children were all attending Irish-medium education in Irish-dominant Gaeltacht regions and in immersion education schools outside of these regions. Data and Analysis: Participants were identified as being from either bilingual Irish- and English-speaking homes or English-dominant homes. A mixed-factorial analysis of variance found a significant main effect of age and language background, but no interaction. Post hoc comparisons revealed that those from Bilingual-speaking homes had significantly higher Irish receptive vocabulary scores than those from English-dominant homes. Linear regression models showed that the receptive vocabulary scores of children in immersion schools grew by an average of 21 words per year between the ages of five and seven, compared to almost 12 words per year in Gaeltacht schools. Findings/Conclusions: The findings demonstrate the advantages of immersion education and the need for vocabulary enrichment of children in the Gaeltacht. However, the complexities of developing assessments for first language speakers of a minority language that is in conflict with a second language variety of that language and the majority English language are also highlighted. Significance/Implications: The implications of this study are that immersion schooling is advantageous to the Irish vocabulary of children, but that children from Gaeltacht schools may require vocabulary enrichment that is sufficiently complex to address their needs. Limitations: Limitations to this study include the uneven number of children from each language background/school location and incomplete background details from the children, such as socio-economic status and language use amongst peers. [ABSTRACT FROM AUTHOR]

People with Down syndrome (DS) can experience difficulties with speech production that can impact on speech intelligibility. In previous research, both perceptual and acoustic analysis has shown that people with DS can have difficulties with speech production in the areas of respiration, phonation, articulation, resonance and prosody. However, these studies have investigated various aspects of speech production separately. No study has examined all components of speech production in one single study and considered how these components, if impaired, may impact on speech intelligibility in DS. This paper presents the data of three male speakers with DS and three age- and gender-matched controls as a case series. The participants' speech samples were analysed using a number of perceptual and acoustic parameters, across the major components of speech production – respiration, phonation, articulation, resonance, and prosody. Results showed that different areas of speech production were affected in each participant, to different extents. The main perceptual difficulties included poor voice quality, monopitch, and monoloudness. Acoustic findings showed a higher mean F0, lower harmonics-to-noise ratio and longer voice onset times. These preliminary findings show that people with DS can present with mixed profiles of speech production that can affect speech intelligibility. When assessing speech production in DS, clinicians need to evaluate all components of speech production and consider how they may be impacting intelligibility. [ABSTRACT FROM AUTHOR]