27 results on '"Noris, G"'
Search Results
2. A Cross-Sectional Analysis of Self-Reported Needs and Health Service Utilization Among Transgender Women in Lima, Perú
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Carosella, Elizabeth A., primary, Huerta, Leyla, additional, Galea, Jerome T., additional, Lecca, Leonid, additional, Ramos, Karen, additional, Hernández, Noris G., additional, Franke, Molly F., additional, and Peinado, Jesús, additional
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- 2023
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3. A Cross-Sectional Analysis of Self-Reported Needs and Health Service Utilization Among Transgender Women in Lima, Perú
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Elizabeth A. Carosella, Leyla Huerta, Jerome T. Galea, Leonid Lecca, Karen Ramos, Noris G. Hernández, Molly F. Franke, and Jesús Peinado
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Psychiatry and Mental health ,Urology ,Public Health, Environmental and Occupational Health ,Obstetrics and Gynecology ,Dermatology - Abstract
PurposeGlobally, transgender women (TGW) experience wide-ranging barriers to health and care, with disproportionately high risks of infectious and chronic diseases. Despite these vulnerabilities, research on access to care for transgender populations in low- and middle-income countries is extremely limited. Furthermore, existing studies have primarily focused on human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS), with less emphasis on TGW’s broader health needs. This study analyzed patterns of morbidity and health service uptake among TGW in Lima, Peru. The purpose was to better understand health outreach and service needs to inform targeting and design of future community-level interventions.MethodsThis cross-sectional study surveyed a convenience sample of 301 TGW in metropolitan Lima, Peru. Data was collected between September – October 2020. This paper provides descriptive statistics and results of bivariate and multivariable regression models.ResultsHealth coverage and access to care were suboptimal. Less education and older age were positively associated with illness and HIV and tuberculosis (TB) testing. Gender identity sub-group (i.e., woman, trans or transgender, transsexual, “transformista,” “travesti,” and other) was associated with HIV testing and pre-exposure prophylaxis (PrEP) usage. Both awareness of and interest in PrEP were low, as was usage among those who were interested in taking PrEP.ConclusionFuture public health efforts should be tailored to meet the diverse needs of TGW, expand TB testing, bridge the gap between PrEP interest and use, and increase insurance coverage and access to trans-friendly services to promote improved health outcomes.
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- 2023
4. Effects of Manidipine and Delapril in Hypertensive Patients With Type 2 Diabetes Mellitus
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Ruggenenti, P, Lauria, G, Iliev, IP, Fassi, A, Ilieva, AP, Rota, S, Chiurchiu, C, Barlovic, DP, Sghirlanzoni, A, Lombardi, R, Penza, P, CAVALETTI, GUIDO ANGELO, Piatti, ML, Frigeni, B, Filipponi, M, Rubis, N, Noris, G, Motterlini, N, Ene Iordache, B, Gaspari, F, Perna, A, Zaletel, J, Bossi, A, Dodesini, AR, TREVISAN, ROBERTO, Remuzzi, G, DEMAND Study Investigators, Parvanova, IA, Petrov, II, Yakymchuk, S, Arnoldi, F, Prandini, S, Kocijancic, A, Pongrac, D, Prezelj, J, Gala, T, Kersnik, M, Trevisan, G, Lepore, G, Mondo, E, Inversi, F, Mangili, R, Bruno, S, Brusegan, V, Lecchi, V, Belviso, A, Genovese, S, Pareyson, D, Camozzi, F, Cavaletti, G, Marzorati, L, MARMIROLI, PAOLA LORENA, Mattavelli, L, Tadini, S, Gherardi, G, Calini, W, Diadei, O, Rossoni, D, Villa, D, Carminati, S, Agus, E, Remuzzi, A, Giuliano, GA, Ganeva, M, Cannata, AN, Carrara, F, Cella, C, Centemeri, E, Ferrari, S, Petrò, C, Savoldelli, E, Stucchi, N, Boccardo, P, Perico, N, Peracchi, S, Gelmi, S, Mecca, G, Imbimbo, B, Alberici, M, Gardini, F, Lauria, G., Ruggenenti, P, Lauria, G, Iliev, I, Fassi, A, Ilieva, A, Rota, S, Chiurchiu, C, Barlovic, D, Sghirlanzoni, A, Lombardi, R, Penza, P, Cavaletti, G, Piatti, M, Frigeni, B, Filipponi, M, Rubis, N, Noris, G, Motterlini, N, Ene Iordache, B, Gaspari, F, Perna, A, Zaletel, J, Bossi, A, Dodesini, A, Trevisan, R, Remuzzi, G, DEMAND Study, I, Parvanova, I, Petrov, I, Yakymchuk, S, Arnoldi, F, Prandini, S, Kocijancic, A, Pongrac, D, Prezelj, J, Gala, T, Kersnik, M, Trevisan, G, Lepore, G, Mondo, E, Inversi, F, Mangili, R, Bruno, S, Brusegan, V, Lecchi, V, Belviso, A, Genovese, S, Pareyson, D, Camozzi, F, Marzorati, L, Marmiroli, P, Mattavelli, L, Tadini, S, Gherardi, G, Calini, W, Diadei, O, Rossoni, D, Villa, D, Carminati, S, Agus, E, Remuzzi, A, Giuliano, G, Ganeva, M, Cannata, A, Carrara, F, Cella, C, Centemeri, E, Ferrari, S, Petrò, C, Savoldelli, E, Stucchi, N, Boccardo, P, Perico, N, Peracchi, S, Gelmi, S, Mecca, G, Imbimbo, B, Alberici, M, and Gardini, F
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Adult ,Blood Glucose ,Male ,Dihydropyridines ,medicine.medical_specialty ,Diabetic neuropathy ,Urology ,Renal function ,Delapril ,Angiotensin-Converting Enzyme Inhibitors ,Kidney Function Tests ,Placebo ,Risk Assessment ,Severity of Illness Index ,Drug Administration Schedule ,Piperazines ,Body Mass Index ,Manidipine ,Double-Blind Method ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Diabetic Nephropathies ,Nitrobenzenes ,Aged ,Dose-Response Relationship, Drug ,diabetes ,business.industry ,Hazard ratio ,Middle Aged ,Calcium Channel Blockers ,Prognosis ,medicine.disease ,Survival Rate ,Treatment Outcome ,Endocrinology ,Diabetes Mellitus, Type 2 ,Hypertension ,Indans ,Albuminuria ,Drug Therapy, Combination ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
To assess whether angiotensin-converting enzyme inhibitors and third-generation dihydropyridine calcium channel blockers ameliorate diabetic complications, we compared glomerular filtration rate (GFR; primary outcome), cardiovascular events, retinopathy, and neuropathy in 380 hypertensive type 2 diabetics with albuminuria 2 (IQR: 0.16–0.50 mL/min per 1.73 m 2 ) on combined therapy, 0.36 mL/min per 1.73 m 2 (IQR: 0.18–0.53 mL/min per 1.73 m 2 ) on delapril, and 0.30 mL/min per 1.73 m 2 (IQR: 0.12–0.50 mL/min per 1.73 m 2 ) on placebo ( P =0.87 and P =0.53 versus combined therapy or delapril, respectively). Similar findings were observed when baseline GFR values were not considered for slope analyses. Albuminuria was stable in the 3 treatment groups. The hazard ratio (95% CI) for major cardiovascular events between combined therapy and placebo was 0.17 (0.04–0.78; P =0.023). Among 192 subjects without retinopathy at inclusion, the hazard ratio for developing retinopathy between combined therapy and placebo was 0.27 (0.07–0.99; P =0.048). Among 200 subjects with centralized neurological evaluation, the odds ratios for peripheral neuropathy at 3 years between combined therapy or delapril and placebo were 0.45 (0.24–0.87; P =0.017) and 0.52 (0.27–0.99; P =0.048), respectively. Glucose disposal rate decreased from 5.8±2.4 to 5.3±1.9 mg/kg per min on placebo ( P =0.03) but did not change on combined or delapril therapy. Treatment was well tolerated. In hypertensive type 2 diabetic patients, combined manidipine and delapril therapy failed to slow GFR decline but safely ameliorated cardiovascular disease, retinopathy, and neuropathy and stabilized insulin sensitivity.
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- 2011
5. Genetic variants in the Lipoprotein (a) gene in Mestizo and Amerindian populations from Mexico
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López, L., primary, Hernández-Tobías, E.A., additional, Noris, G., additional, Santana, C., additional, and Gómez, R., additional
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- 2016
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6. Interethnic variation of the MMP-9 microsatellite in Amerindian and Mexican Mestizo populations: considerations for genetic association studies
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Camacho-Mejorado, R., primary, Noris, G., additional, Santana, C., additional, Magaña, J.J., additional, Majluf-Cruz, A., additional, Arellano-Galindo, J., additional, De la Peña, A., additional, Hernández-Juárez, J., additional, Calderón-Aranda, E.S., additional, Meraz-Ríos, M.A., additional, and Gómez, R., additional
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- 2015
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7. High versus standard dose methylprednisolone in the acute phase of idiopathic thrombotic thrombocytopenic purpura: a randomized study. Ann Hematol
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Gugliotta, L, Luppi, M, Laurenti, Luca, Balduini, Cl, Klersy, C, Pieresca, C, Quintini, G, Iuliano, F, Re, R, Spedini, P, Bianelli, N, Zaccaria, A, Pogliani, Em, Musso, R, Bobbio Pallavicini, E, Quarta, G, Galieni, P, Fragasso, A, Casella, G, Noris, G, and Ascari, E.
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Settore MED/15 - MALATTIE DEL SANGUE ,cll - Published
- 2010
8. Effects of Manidipine and Delapril in Hypertensive Patients With Type 2 Diabetes Mellitus: The Delapril and Manidipine for Nephroprotection in Diabetes (DEMAND) Randomized Clinical Trial
- Author
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Ruggenenti, P, Lauria, G, Iliev, I, Fassi, A, Ilieva, A, Rota, S, Chiurchiu, C, Barlovic, D, Sghirlanzoni, A, Lombardi, R, Penza, P, Cavaletti, G, Piatti, M, Frigeni, B, Filipponi, M, Rubis, N, Noris, G, Motterlini, N, Ene Iordache, B, Gaspari, F, Perna, A, Zaletel, J, Bossi, A, Dodesini, A, Trevisan, R, Remuzzi, G, DEMAND Study, I, Parvanova, I, Petrov, I, Yakymchuk, S, Arnoldi, F, Prandini, S, Kocijancic, A, Pongrac, D, Prezelj, J, Gala, T, Kersnik, M, Trevisan, G, Lepore, G, Mondo, E, Inversi, F, Mangili, R, Bruno, S, Brusegan, V, Lecchi, V, Belviso, A, Genovese, S, Pareyson, D, Camozzi, F, Marzorati, L, Marmiroli, P, Mattavelli, L, Tadini, S, Gherardi, G, Calini, W, Diadei, O, Rossoni, D, Villa, D, Carminati, S, Agus, E, Remuzzi, A, Giuliano, G, Ganeva, M, Cannata, A, Carrara, F, Cella, C, Centemeri, E, Ferrari, S, Petrò, C, Savoldelli, E, Stucchi, N, Boccardo, P, Perico, N, Peracchi, S, Gelmi, S, Mecca, G, Imbimbo, B, Alberici, M, Gardini, F, Iliev, IP, Ilieva, AP, Barlovic, DP, CAVALETTI, GUIDO ANGELO, Piatti, ML, Dodesini, AR, TREVISAN, ROBERTO, DEMAND Study Investigators, Parvanova, IA, Petrov, II, MARMIROLI, PAOLA LORENA, Giuliano, GA, Cannata, AN, Lauria, G., Ruggenenti, P, Lauria, G, Iliev, I, Fassi, A, Ilieva, A, Rota, S, Chiurchiu, C, Barlovic, D, Sghirlanzoni, A, Lombardi, R, Penza, P, Cavaletti, G, Piatti, M, Frigeni, B, Filipponi, M, Rubis, N, Noris, G, Motterlini, N, Ene Iordache, B, Gaspari, F, Perna, A, Zaletel, J, Bossi, A, Dodesini, A, Trevisan, R, Remuzzi, G, DEMAND Study, I, Parvanova, I, Petrov, I, Yakymchuk, S, Arnoldi, F, Prandini, S, Kocijancic, A, Pongrac, D, Prezelj, J, Gala, T, Kersnik, M, Trevisan, G, Lepore, G, Mondo, E, Inversi, F, Mangili, R, Bruno, S, Brusegan, V, Lecchi, V, Belviso, A, Genovese, S, Pareyson, D, Camozzi, F, Marzorati, L, Marmiroli, P, Mattavelli, L, Tadini, S, Gherardi, G, Calini, W, Diadei, O, Rossoni, D, Villa, D, Carminati, S, Agus, E, Remuzzi, A, Giuliano, G, Ganeva, M, Cannata, A, Carrara, F, Cella, C, Centemeri, E, Ferrari, S, Petrò, C, Savoldelli, E, Stucchi, N, Boccardo, P, Perico, N, Peracchi, S, Gelmi, S, Mecca, G, Imbimbo, B, Alberici, M, Gardini, F, Iliev, IP, Ilieva, AP, Barlovic, DP, CAVALETTI, GUIDO ANGELO, Piatti, ML, Dodesini, AR, TREVISAN, ROBERTO, DEMAND Study Investigators, Parvanova, IA, Petrov, II, MARMIROLI, PAOLA LORENA, Giuliano, GA, Cannata, AN, and Lauria, G.
- Abstract
To assess whether angiotensin-converting enzyme inhibitors and third-generation dihydropyridine calcium channel blockers ameliorate diabetic complications, we compared glomerular filtration rate (GFR; primary outcome), cardiovascular events, retinopathy, and neuropathy in 380 hypertensive type 2 diabetics with albuminuria <200 mg/min included in a multicenter, double-blind, placebo-controlled trial (DEMAND [Delapril and Manidipine for Nephroprotection in Diabetes]) and randomized to 3-year treatment with manidipine/delapril combination (10/30 mg/d; n=126), delapril (30 mg/d; n=127), or placebo (n=127). GFR was centrally measured by iohexol plasma clearance. Median monthly GFR decline (interquartile range [IQR]) was 0.32 mL/min per 1.73 m(2) (IQR: 0.16-0.50 mL/min per 1.73 m(2)) on combined therapy, 0.36 mL/min per 1.73 m(2) (IQR: 0.18-0.53 mL/min per 1.73 m(2)) on delapril, and 0.30 mL/min per 1.73 m(2) (IQR: 0.12-0.50 mL/min per 1.73 m(2)) on placebo (P=0.87 and P=0.53 versus combined therapy or delapril, respectively). Similar findings were observed when baseline GFR values were not considered for slope analyses. Albuminuria was stable in the 3 treatment groups. The hazard ratio (95% CI) for major cardiovascular events between combined therapy and placebo was 0.17 (0.04-0.78; P=0.023). Among 192 subjects without retinopathy at inclusion, the hazard ratio for developing retinopathy between combined therapy and placebo was 0.27 (0.07-0.99; P=0.048). Among 200 subjects with centralized neurological evaluation, the odds ratios for peripheral neuropathy at 3 years between combined therapy or delapril and placebo were 0.45 (0.24-0.87; P=0.017) and 0.52 (0.27-0.99; P=0.048), respectively. Glucose disposal rate decreased from 5.8±2.4 to 5.3±1.9 mg/kg per min on placebo (P=0.03) but did not change on combined or delapril therapy. Treatment was well tolerated. In hypertensive type 2 diabetic patients, combined manidipine and delapril therapy failed to slow GFR decline bu
- Published
- 2011
9. Smart Scribbles for Sketch Segmentation
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Noris, G., primary, Sýkora, D., additional, Shamir, A., additional, Coros, S., additional, Whited, B., additional, Simmons, M., additional, Hornung, A., additional, Gross, M., additional, and Sumner, R., additional
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- 2012
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10. Temporal noise control for sketchy animation
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Noris, G., primary, Sýkora, D., additional, Coros, S., additional, Whited, B., additional, Simmons, M., additional, Hornung, A., additional, Gross, M., additional, and Sumner, R. W., additional
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- 2011
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11. Human umbilical vein endothelial cells express multiple prolactin isoforms
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Corbacho, AM, primary, Macotela, Y, additional, Nava, G, additional, Torner, L, additional, Duenas, Z, additional, Noris, G, additional, Morales, MA, additional, Martinez De La Escalera, G, additional, and Clapp, C, additional
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- 2000
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12. Expression of prolactin mRNA and of prolactin-like proteins in endothelial cells: evidence for autocrine effects
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Clapp, C, primary, Lopez-Gomez, FJ, additional, Nava, G, additional, Corbacho, A, additional, Torner, L, additional, Macotela, Y, additional, Duenas, Z, additional, Ochoa, A, additional, Noris, G, additional, Acosta, E, additional, Garay, E, additional, and Martinez de la Escalera, G, additional
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- 1998
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13. Histamine directly stimulates gonadotropin-releasing hormone secretion from GT1-1 cells via H1 receptors coupled to phosphoinositide hydrolysis.
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Noris, G, primary, Hol, D, additional, Clapp, C, additional, and Martínez de la Escalera, G, additional
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- 1995
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14. Genetic Analysis of 17 Y-STRs in a Mestizo Population from the Central Valley of Mexico
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Santana, Carla, Noris, Gino, Meraz-Ríos, Marco Antonio, Magaña, Jonathan J., Calderon-Aranda, Emma S., Muñoz, Maria de Lourdes, and Gómez, Rocío
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- 2015
15. Proteolytic cleavage confers nitric oxide synthase inducing activity upon prolactin.
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Corbacho, A M, Nava, G, Eiserich, J P, Noris, G, Macotela, Y, Struman, I, Martinez De La Escalera, G, Freeman, B A, and Clapp, C
- Abstract
Prolactin (PRL), originally associated with milk secretion, is now known to possess a wide variety of biological actions and diverse sites of production beyond the pituitary. Proteolytic cleavage is a common post-translational modification that can either activate precursor proteins or confer upon the peptide fragment unique biological actions not exerted by the parent molecule. Recent studies have demonstrated that the 16-kDa N-terminal proteolytic cleavage product of PRL (16K-PRL) acts as a potent inhibitor of angiogenesis. Despite previous demonstrations of 16K-PRL production in vivo, biological functions beyond its antiangiogenic actions remain unknown. Here we show that 16K-PRL, but not full-length PRL, acts to promote the expression of the inducible isoform of nitric oxide synthase (iNOS) and nitric oxide (*NO) production by pulmonary fibroblasts and alveolar type II cells with potency comparable with the proinflammatory cytokines interleukin-1beta, interferon gamma, and tumor necrosis factor alpha. The differential effect of 16K-PRL versus PRL occurs through a receptor distinct from known PRL receptors. Additionally, pulmonary fibroblasts express the PRL gene and endogenously produce 16K-PRL, suggesting that this pathway may serve both autocrine and paracrine roles in the regulation of *NO production. These results reveal that proteolytic cleavage of PRL confers upon this classical hormone potent iNOS inducing activity, suggesting its role in inflammatory/immune processes.
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- 2000
16. Correction to ' ALOX5, LPA, MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans'.
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Camacho-Mejorado R, Gómez R, Torres-Sánchez LE, Alhelí Hernández-Tobías E, Noris G, Santana C, Magaña JJ, Orozco L, de la Peña-Díaz A, de la Luz Arenas-Sordo M, Antonio Meraz-Ríos M, and Majluf-Cruz A
- Abstract
[This corrects the article DOI: 10.1098/rsos.190775.]., (© 2020 The Authors.)
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- 2020
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17. ALOX5 , LPA , MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans.
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Camacho-Mejorado R, Gómez R, Torres-Sánchez LE, Alhelí Hernández-Tobías E, Noris G, Santana C, Magaña JJ, Orozco L, de la Peña-Díaz A, de la Luz Arenas-Sordo M, Meraz-Ríos MA, and Majluf-Cruz A
- Abstract
Atherothrombosis is the cornerstone of cardiovascular diseases and the primary cause of death worldwide. Genetic contribution to disturbances in lipid metabolism, coagulation, inflammation and oxidative stress increase the susceptibility to its development and progression. Given its multifactorial nature, the multiloci studies have been proposed as potential predictors of susceptibility. A cross-sectional study was conducted to explore the contribution of nine genes involved in oxidative stress, inflammatory and thrombotic processes in 204 subjects with atherothrombosis matched by age and gender with a healthy group ( n = 204). To evaluate the possibility of spurious associations owing to the Mexican population genetic heterogeneity as well as its ancestral origins, 300 unrelated mestizo individuals and 329 Native Americans were also included. ALOX5 , LPA , MMP9 and TPO gene polymorphisms, as well as their multiallelic combinations, were twice to four times more frequent in those individuals with clinical manifestations of atherothrombosis than in the healthy group. Once adjusting for population stratification was done, these differences remained. Our results add further evidence on the contribution of ALOX5 , LPA , MMP9 and TPO polymorphisms to atherothrombosis development in the middle-aged group, emphasizing the multiethnic studies in search of gene risk polymorphisms., Competing Interests: The authors declare no competing interests and no financial relationship with the organization that sponsored the present research., (© 2020 The Authors.)
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- 2020
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18. Evidence of a Prototheca Zopfii Genotype 2 Disseminated Infection in a Dog with Cutaneous Lesions.
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Carfora V, Noris G, Caprioli A, Iurescia M, Stravino F, and Franco A
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- Animals, Dogs, Infections diagnosis, Infections pathology, Male, Prototheca genetics, Dog Diseases diagnosis, Dog Diseases pathology, Genotype, Infections veterinary, Prototheca classification, Prototheca isolation & purification
- Abstract
Protothecosis is a disease caused by saprophyte aerobic unicellular algae belonging to the genus Prototheca. In dogs, it mainly occurs as a disseminated form, with initial clinical manifestations often referable to the gastrointestinal tract, followed by typical ocular and neurological signs. So far, Prototheca zopfii genotype 2 infection has been reported in severe forms of disseminated protothecosis, while in dogs has never been associated with cutaneous forms. In this study, we describe a case of Prototheca zopfii genotype 2 infection in a dog characterized by nodular and ulcerative dermatitis and with evidence of dissemination. In December 2015, a 5-year-old unneutered male English Setter dog was presented with a 4-month history of footpads ulcerations and multifocal nodular lesions (3-5 cm diameter) on both front limbs. Cytological examination of the aspirated fluid collected from all nodules revealed the presence of sporangic forms compatible with Prototheca spp. organisms. Suspected Prototheca spp. colonies were isolated from the aspirated fluid and identified as Prototheca zopfii genotype 2 by molecular methods. Few days after the visit, the patient developed serious neurological and ocular signs, and the owners elected humane euthanasia. To the authors' knowledge, this case could represent the first report of a disseminated Prototheca zopfii genotype 2 infection associated with cutaneous lesions in a dog. This study underlines the importance of considering Prototheca zopfii genotype 2 infection in the differential etiological diagnosis of nodular and ulcerative dermatitis in dogs.
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- 2017
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19. Forensic-paternity effectiveness and genetics population analysis of six non-CODIS mini-STR loci (D1S1656, D2S441, D6S1043, D10S1248, D12S391, D22S1045) and SE33 in Mestizo and Amerindian populations from Mexico.
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Burguete-Argueta N, Martínez De la Cruz B, Camacho-Mejorado R, Santana C, Noris G, López-Bayghen E, Arellano-Galindo J, Majluf-Cruz A, Antonio Meraz-Ríos M, and Gómez R
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- Female, Humans, Male, Mexico, Polymerase Chain Reaction, Principal Component Analysis, Statistics as Topic, Ethnicity genetics, Forensic Genetics, Genetic Loci, Genetics, Population, Indians, South American genetics, Microsatellite Repeats genetics, Paternity
- Abstract
Background: STRs are powerful tools intensively used in forensic and kinship studies., Aim: In order to assess the effectiveness of non-CODIS genetic markers in forensic and paternity tests, the genetic composition of six mini short tandem repeats-mini-STRs-(D1S1656, D2S441, D6S1043, D10S1248, D12S391, D22S1045) and the microsatellite SE33 in Mestizo and Amerindian populations from Mexico were studied., Subjects and Methods: Using multiplex polymerase chain reactions and capillary electrophoresis, this study genotyped all loci from 870 chromosomes and evaluated the statistical genetic parameters., Results: All mini-STRs studied were in agreement with HW and linkage equilibrium; however, an important HW departure for SE33 was found in the Mestizo population (p ≤ 0.0001). Regarding paternity and forensic statistical parameters, high values of combined power discrimination and mean power of exclusion were found using these seven markers. The principal co-ordinate analysis based on allele frequencies of three mini-STRs showed the complex genetic architecture of the Mestizo population., Conclusion: The results indicate that this set of loci is suitable to genetically identify individuals in the Mexican population, supporting its effectiveness in human identification casework. In addition, these findings add new statistical values and emphasise the importance of the use of non-CODIS markers in complex populations in order to avoid erroneous assumptions.
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- 2016
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20. PPARG-LYPLAL1 Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females.
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Hernández-Tobías EA, Torres-Sánchez L, Noris G, Santana C, Samano MR, Arellano-Galindo J, Arenas-Sordo ML, Brooks D, Rodríguez-Ventura AL, Meraz-Ríos MA, and Gómez R
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- Adolescent, Alleles, Body Mass Index, Female, Genotype, Humans, Male, Mexico, Obesity genetics, Overweight genetics, Polymorphism, Single Nucleotide, Waist Circumference, Lysophospholipase genetics, Mexican Americans genetics, Obesity ethnology, Overweight ethnology, PPAR gamma genetics
- Abstract
Objective: We studied multi-loci variants to identify the contribution of six candidate genes ( ADIPOQ, CDH13, LYPLAL1, MC4R, PPARG and PGC1A ) in the development of obesity and overweight., Design: We genotyped 404 chromosomes with eleven SNPs in Mexican female adolescents, who were subdivided into two groups (obesity-overweight and normal-weight) using the World Health Organization parameters. Genomic (800 chromosomes) and ancestral (208 chromosomes) controls were included to reduce the population bias. Anthropometric measurements, biochemical parameters, and caloric intake were obtained only in the groups of Mexican female adolescents., Results: A positive genotype-phenotype association was found that involves the multi-allelic combination of three risk alleles (one in PPARG and two in LYPLAL1 ) with obesity and overweight (OR=3.1, P=.010). This combination also exhibited a significant association with waist circumference (P=.030) and triglycerides levels (P=.030). These associations were supported by a logistic regression analysis adjusted for several confounding variables., Conclusions: Our data suggest the joint participation of PPARG - LYPLAL1 genes in metabolic disorders development. Hence, these genes could act as potential biomarkers in obesity and overweight. Our findings underscore the complexity of metabolic disorders and provide evidence about the importance of multi-loci analysis to study complex diseases., Competing Interests: Conflicts of Interest: None declared.
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- 2016
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21. Androgen receptor CAG polymorphism and sporadic and early-onset prostate cancer among Mexican men.
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Gómez R, Torres-Sánchez L, Camacho-Mejorado R, Burguete-García AI, Vázquez-Salas RA, Martínez-Nava GA, Santana C, and Noris G
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- Adult, Age of Onset, Aged, Aged, 80 and over, Alleles, Case-Control Studies, Gene Frequency, Genotype, Humans, Male, Mexico epidemiology, Middle Aged, Neoplasm Grading, Odds Ratio, Population Surveillance, Prostatic Neoplasms pathology, Risk, Trinucleotide Repeat Expansion, Polymorphism, Genetic, Prostatic Neoplasms epidemiology, Prostatic Neoplasms genetics, Receptors, Androgen genetics, Trinucleotide Repeats
- Abstract
A short CAG repeat length in the gene encoding for the androgen receptor (AR) has been associated with prostate cancer (PC) risk and aggressiveness. In Latino men, information on this association is scarce. Hence, the aim of this study was to evaluate this association in Mexican males. Using fragment analysis by capillary electrophoresis, we determined the number of CAG repeats-(CAG)n-in AR gene from 158 incident PC cases and 326 age-matched healthy controls (±5 years), residing in Mexico City, Mexico. According to Gleason scale and age at diagnosis, cases were classified as high (⩾7) and low grade (<7), as well as early onset (<60 years) or late onset PC (⩾60 years). At diagnosis, 78% of cases were classified as high-grade and 26.6% as early onset. Men with sporadic (no family history of PC) and early-onset PC presented shorter CAG repeat length than controls (18.6±2.2 vs 19.5±2.5; P=0.02). Lower number of CAG repeats (CAG)⩽19 were associated with a greater risk for early-onset PC (odds ratio: 2.31; 95% confidence interval: 1.14-4.69). CAG repeat length could increase the risk for sporadic and early-onset PC. The best cutoff point for identifying at-risk subjects was (CAG)19. However, further studies are necessary to replicate our findings in subjects with a family history of PC and also to evaluate the association between CAG repeats length and disease progression.
- Published
- 2016
- Full Text
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22. Live texturing of augmented reality characters from colored drawings.
- Author
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Magnenat S, Ngo DT, Zünd F, Ryffel M, Noris G, Rothlin G, Marra A, Nitti M, Fua P, Gross M, and Sumner RW
- Abstract
Coloring books capture the imagination of children and provide them with one of their earliest opportunities for creative expression. However, given the proliferation and popularity of digital devices, real-world activities like coloring can seem unexciting, and children become less engaged in them. Augmented reality holds unique potential to impact this situation by providing a bridge between real-world activities and digital enhancements. In this paper, we present an augmented reality coloring book App in which children color characters in a printed coloring book and inspect their work using a mobile device. The drawing is detected and tracked, and the video stream is augmented with an animated 3-D version of the character that is textured according to the child's coloring. This is possible thanks to several novel technical contributions. We present a texturing process that applies the captured texture from a 2-D colored drawing to both the visible and occluded regions of a 3-D character in real time. We develop a deformable surface tracking method designed for colored drawings that uses a new outlier rejection algorithm for real-time tracking and surface deformation recovery. We present a content creation pipeline to efficiently create the 2-D and 3-D content. And, finally, we validate our work with two user studies that examine the quality of our texturing algorithm and the overall App experience.
- Published
- 2015
- Full Text
- View/download PDF
23. Genetic analysis of 17 Y-STRs in a Mestizo population from the Central Valley of Mexico.
- Author
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Santana C, Noris G, Meraz-Ríos MA, Magaña JJ, Calderon-Aranda ES, Muñoz Mde L, and Gómez R
- Subjects
- Black People, Gene Frequency, Genetic Variation genetics, Genetics, Population, Haplotypes genetics, Humans, Mexico epidemiology, White People, Chromosomes, Human, Y genetics, Indians, North American genetics, Phylogeny
- Abstract
This study aims to portray the complex diversity of the Mexican Mestizo population, which represents 98.8% of the entire population of Mexico. We compiled extended haplotype data of the Y chromosome from populations in the Central Valley of Mexico (CVM), which we compared with other Mestizo and parental (Amerindian, European, and African) populations. A complex ancestral relationship was found in the CVM population, suggesting cosmopolitan origins. Nevertheless, the most preeminent lineages point toward a European ancestry, where the R1b lineage was most frequent. In addition, important frequencies of Amerindian lineages were also found in the Mestizo sample studied. Interestingly, the Amerindian ancestry showed a remarkable substructure, which was represented by the two main founding lineages: QL54 (× M3) and M3. However, even within each lineage a high diversity was found despite the small number of sample bearers of these lineages. Further, we detected important genetic differences between the CVM populations and the Mexican Mestizo populations from the north and south. This result points to the fact that Mestizo populations present different ancestral proportions, which are related to the demographic events that gave origin to each population. Finally, we provide additional forensic statistical parameters that are useful in the interpretation of genetic analysis where autosomal loci are limited. Our findings illustrate the complex genetic background of the Mexican Mestizo population and reinforce the need to encompass more geographic regions to generate more robust data for forensic applications.
- Published
- 2014
- Full Text
- View/download PDF
24. Association of vWA and TPOX polymorphisms with venous thrombosis in Mexican mestizos.
- Author
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Meraz-Ríos MA, Majluf-Cruz A, Santana C, Noris G, Camacho-Mejorado R, Acosta-Saavedra LC, Calderón-Aranda ES, Hernández-Juárez J, Magaña JJ, and Gómez R
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Genetic Markers genetics, Humans, Male, Mexico epidemiology, Microsatellite Repeats genetics, Middle Aged, Prevalence, Risk Factors, Young Adult, Genetic Predisposition to Disease ethnology, Genetic Predisposition to Disease genetics, Iodide Peroxidase genetics, Polymorphism, Single Nucleotide genetics, Venous Thrombosis ethnology, Venous Thrombosis genetics, von Willebrand Factor genetics
- Abstract
Objective: Venous thromboembolism (VTE) is a multifactorial disorder and, worldwide, the most important cause of morbidity and mortality. Genetic factors play a critical role in its aetiology. Microsatellites are the most important source of human genetic variation having more phenotypic effect than many single nucleotide polymorphisms. Hence, we evaluate a possible relationship between VTE and the genetic variants in von Willebrand factor, human alpha fibrinogen, and human thyroid peroxidase microsatellites to identify possible diagnostic markers., Methods: Genotypes were obtained from 177 patients with VTE and 531 nonrelated individuals using validated genotyping methods. The allelic frequencies were compared; Bayesian methods were used to correct population stratification to avoid spurious associations., Results: The vWA-18, TPOX-9, and TPOX-12 alleles were significantly associated with VTE. Moreover, subjects bearing the combination vWA-18/TPOX-12 loci exhibited doubled risk for VTE (95% CI = 1.02-3.64), whereas the combination vWA-18/TPOX-9 showed an OR = 10 (95% CI = 4.93-21.49)., Conclusions: The vWA and TPOX microsatellites are good candidate biomarkers in venous thromboembolism diseases and could help to elucidate their origins. Additionally, these polymorphisms could become useful markers for genetic studies of VTE in the Mexican population; however, further studies should be done owing that this data only show preliminary evidence.
- Published
- 2014
- Full Text
- View/download PDF
25. Mexican mestizo population sub-structure: effects on genetic and forensic statistical parameters.
- Author
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Noris G, Santana C, Meraz-Ríos MA, de Lourdes Munoz M, Majluf-Cruz A, Magaña JJ, Granados J, Quezada R, Revilla MC, Martínez-Salas S, Xihuitl S, Martínez de la Escalera G, Díaz-Badillo A, Calderon-Aranda ES, and Gómez R
- Subjects
- Forensic Genetics, Gene Frequency, Genetic Loci, Genetic Testing, Genotype, Humans, Linkage Disequilibrium, Mexico, Models, Genetic, Models, Statistical, Paternity, Black People genetics, Indians, North American genetics, Microsatellite Repeats, White People genetics
- Abstract
Since Mexican mestizos are an admixed population, it is necessary to determine the effects that the substructure of the population has on genetic and forensic parameters. With this aim, a study was performed with 15 STR loci (CODIS plus D2S1338 and D19S433) on 1,640 unrelated Mexican mestizos. We determine allele and genotypic frequencies observing departure from Hardy-Weinberg expectation (12 out of 15 loci, with an excess of homozygotes, Fis > 0), as well as pairs of loci in an apparent linkage disequilibrium (13 of 92 loci). We conducted a test for genetic population stratification, the results show that the Mexican mestizo population is substructured into three subgroups, which are in HW and linkage equilibrium. The combination of the 15 loci in the whole population has high forensic efficiency with the capacity to genetically discriminate one individual in one quintillion (1/10(18)). Our data potentially validates the use of these 15 STR loci to establish forensic identity and parentage testing for legal purposes, and offers a powerful tool for genetic variation analysis. However, given that the population is stratified, we highly recommend applying a correction with the inbreeding coefficient in calculations of paternity and forensic studies to avoid erroneous assumptions.
- Published
- 2012
- Full Text
- View/download PDF
26. GABA inhibition of immortalized gonadotropin-releasing hormone neuronal excitability involves GABA(A) receptors negatively coupled to cyclic adenosine monophosphate formation.
- Author
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Beltrán-Parrazal L, Noris G, Clapp C, and Martínez de la Escalera G
- Subjects
- 8-Bromo Cyclic Adenosine Monophosphate pharmacology, Baclofen pharmacology, Bicuculline pharmacology, Calcium metabolism, Calcium Channels drug effects, Calcium Channels physiology, Cell Line, Transformed, Cell Membrane physiology, Colforsin pharmacology, Kinetics, Muscimol pharmacology, Potassium pharmacology, Cyclic AMP metabolism, Gonadotropin-Releasing Hormone metabolism, Neurons drug effects, Neurons physiology, Receptors, GABA-A physiology, gamma-Aminobutyric Acid pharmacology
- Abstract
Gamma-aminobutyric acid (GABA) has been implicated in the regulation of reproduction, particularly in the developmental modulation of gonadotropin-releasing hormone (GnRH) secretion. GnRH neurons are innervated by GABA-containing processes, and the administration of GABA stimulates and inhibits GnRH secretion in vivo and in vitro. We have previously shown that GABA can exert both of these actions in sequence, by acting directly on immortalized GnRH neurons. While the stimulation is the result of a GABA(A) receptor-mediated depolarization of the plasma membrane, the mechanism involved in the delayed inhibition is the subject of the present investigation. GABA (1 nM-10 microM) decreased the intracellular concentration of cyclic adenosine monophosphate (cAMP) in a dose- and time-dependent fashion. This effect was blocked by bicuculline and mimicked by muscimol but not by baclofen. To analyze the effect of GABA on cellular excitability, we used fura-2 loaded GT1-7 cells. Activation of voltage-sensitive calcium channels by high K+-induced depolarization (35 mM) increased [Ca2+]i. GABA (10 microM) and muscimol (10 microM) reduced the amplitude of K+-induced [Ca2+]i transients. This inhibition was blocked by forskolin (20 microM) or 8-Br-cAMP (1 mM). Altogether, these results show that GABA(A) receptors mediate a sustained inhibitory effect of GABA on GnRH neurons, and suggest the involvement of the cAMP pathway decreasing cellular excitability.
- Published
- 2001
- Full Text
- View/download PDF
27. Protein tyrosine phosphorylation in leukocyte activation through receptors for IgG.
- Author
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Santana C, Noris G, Espinoza B, and Ortega E
- Subjects
- Amino Acid Sequence, Humans, Membrane Glycoproteins metabolism, Phosphoproteins metabolism, Phosphorylation, Phosphotyrosine metabolism, Signal Transduction, Structure-Activity Relationship, Receptors, IgG physiology
- Abstract
Membrane receptors for the Fc portion of immunoglobulin G (IgG) antibodies (Fc(gamma)Rs) are expressed on almost every type of hematopoietic cells, where they mediate a wide variety of effector functions. A high degree of structural heterogeneity exists among Fc(gamma)Rs. The biological significance of such heterogeneity is unknown, since the structural diversity does not appear to be reflected in the binding specificity nor in the effector functions that each distinct receptor is able to mediate. Recent work has emphasized the essential role of protein tyrosine phosphorylation in the initiation of transmembrane signaling by these receptors. In this article we review the role of protein tyrosine phosphorylation in signal transduction by the different types of Fc(gamma)Rs in order to assess to what extent the structural heterogeneity of this receptor family is related to different activation pathways utilized by each of its members.
- Published
- 1996
- Full Text
- View/download PDF
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