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Androgen receptor CAG polymorphism and sporadic and early-onset prostate cancer among Mexican men.
- Source :
-
Journal of human genetics [J Hum Genet] 2016 Sep; Vol. 61 (9), pp. 781-6. Date of Electronic Publication: 2016 May 19. - Publication Year :
- 2016
-
Abstract
- A short CAG repeat length in the gene encoding for the androgen receptor (AR) has been associated with prostate cancer (PC) risk and aggressiveness. In Latino men, information on this association is scarce. Hence, the aim of this study was to evaluate this association in Mexican males. Using fragment analysis by capillary electrophoresis, we determined the number of CAG repeats-(CAG)n-in AR gene from 158 incident PC cases and 326 age-matched healthy controls (±5 years), residing in Mexico City, Mexico. According to Gleason scale and age at diagnosis, cases were classified as high (⩾7) and low grade (<7), as well as early onset (<60 years) or late onset PC (⩾60 years). At diagnosis, 78% of cases were classified as high-grade and 26.6% as early onset. Men with sporadic (no family history of PC) and early-onset PC presented shorter CAG repeat length than controls (18.6±2.2 vs 19.5±2.5; P=0.02). Lower number of CAG repeats (CAG)⩽19 were associated with a greater risk for early-onset PC (odds ratio: 2.31; 95% confidence interval: 1.14-4.69). CAG repeat length could increase the risk for sporadic and early-onset PC. The best cutoff point for identifying at-risk subjects was (CAG)19. However, further studies are necessary to replicate our findings in subjects with a family history of PC and also to evaluate the association between CAG repeats length and disease progression.
- Subjects :
- Adult
Age of Onset
Aged
Aged, 80 and over
Alleles
Case-Control Studies
Gene Frequency
Genotype
Humans
Male
Mexico epidemiology
Middle Aged
Neoplasm Grading
Odds Ratio
Population Surveillance
Prostatic Neoplasms pathology
Risk
Trinucleotide Repeat Expansion
Polymorphism, Genetic
Prostatic Neoplasms epidemiology
Prostatic Neoplasms genetics
Receptors, Androgen genetics
Trinucleotide Repeats
Subjects
Details
- Language :
- English
- ISSN :
- 1435-232X
- Volume :
- 61
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of human genetics
- Publication Type :
- Academic Journal
- Accession number :
- 27193223
- Full Text :
- https://doi.org/10.1038/jhg.2016.49