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症例は61歳男性で呼吸困難を主訴として来院し, 両側の胸水および心嚢水が認められ入院した.胸水と心嚢水の細胞診により腺癌の心嚢腔への転移を疑ったが, 原発巣を特定できないまま呼吸不全で死亡し, 剖検により心膜原発の中皮腫と診断した.心嚢水の塗抹標本に, Papanicolaou, Giemsa, PAS染色を行った.腫瘍細胞はまりも状あるいは乳頭状に集塊し, ライトグリーンに淡染した細胞質には粘液空胞や細胞辺縁にブリスター様突起を有するものを認めた.また, 核内には明瞭な1～3個の核小体が認められた.PAS染色では, 細胞質辺縁に滴状の陽性反応を示した.

We previously reported that PP1gamma1 is highly expressed in osteosarcoma and chondrosarcoma, and suggested that this protein plays a role in malignancy of osteogenic tumors. In this study, we investigated the correlation of the expression of PP1gamma1 with telomerase activity. PP2A protein was not positive in any of the 5 cases of Ewing's sarcoma, but PP1gamma1 protein was strongly positive in all cases. Furthermore, malignant cells had high telomerase activity. We investigated the correlation of the expression of PP1gamma1 with telomerase activity, and showed that telomerase activity is regulated by protein phosphorylation in Ewing's sarcoma cells.

In this study, we analyzed high expression of protein phosphatase (PP) 2A in Alzheimer's disease brain compared to that of the control brain, which result from hyperphosphorylation of histone H1. PP1alpha and PP1gamma1 were slightly expressed in all cases, but there was no relation to the levels of the phosphate in histone H1.