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Enhanced expression of protein phosphatase 2A associated with hyper-phosphorylation of histone H1 in Alzheimer's disease brain

Authors :
Satoshi, Mori
Yongping, Cao
Kenichi, Sogawa
Kazuya, Kondo
Tohru, Sakai
Norifumi, Hino
Hisakazu, Yamashiro
Masanao, Okada
Kazuo, Miyamoto
Yoji, Kawaguchi
Tasuku, Mashiba
Hiromichi, Norimatsu
Source :
Research communications in molecular pathology and pharmacology.
Publication Year :
2005

Abstract

In this study, we analyzed high expression of protein phosphatase (PP) 2A in Alzheimer's disease brain compared to that of the control brain, which result from hyperphosphorylation of histone H1. PP1alpha and PP1gamma1 were slightly expressed in all cases, but there was no relation to the levels of the phosphate in histone H1.

Subjects

Subjects :
Histones
Alzheimer Disease
Case-Control Studies
Phosphotransferases
Phosphoprotein Phosphatases
Humans
Protein Phosphatase 2
Phosphorylation

Details

ISSN :
10780297
Database :
OpenAIRE
Journal :
Research communications in molecular pathology and pharmacology
Accession number :
edsair.pmid..........ab7ba6baebc678fd30bed7f8a83a6e64

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