135 results on '"Noriaki, Suzuki"'
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2. Coordinated Bank and Cache Coloring for Temporal Protection of Memory Accesses.
- Author
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Noriaki Suzuki, Hyoseung Kim 0001, Dionisio de Niz, Björn Andersson, Lutz Wrage, Mark H. Klein 0001, and Ragunathan Rajkumar
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- 2013
- Full Text
- View/download PDF
3. Temporal changes in the nutrient status of Matsushima Bay after a wastewater plant was destroyed by a tsunami on 11 March 2011
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Motoyuki Hara, Shigeho Kakehi, Yutaka Okumura, Noriaki Suzuki, and Yoshio Masuda
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Hydrology ,Treated water ,Coastal environment ,Nutrients ,Aquatic Science ,Wastewater plant ,Nutrient ,Wastewater ,Streamflow ,Environmental science ,Seawater ,Eutrophication ,Time trend ,Effluent ,Bay ,Tsunami effect - Abstract
We investigated how the nutrient status of Matsushima Bay was affected when a wastewater plant was destroyed by a tsunami in March 2011. The nutrient concentrations in the seawater and the treated water from the wastewater plant increased just after the tsunami, but decreased again to pre-tsunami levels after 2013. The amount of untreated water that passed through the wastewater plant decreased just after the tsunami. It was estimated that approximately 40.7 × 103 m3/day of the treated water from the wastewater plant was discharged to Matsushima Bay; therefore, the quantity of effluent from the wastewater plant was less than one percent of the water inflow from Takagi River and Sendai Bay (which are outside Matsushima Bay) to Matsushima Bay. The nutrient concentrations of seawater in Sendai Bay were lower than those in Matsushima Bay. The results suggest that nutrient concentrations in Matsushima Bay after the tsunami did not increase because any untreated or poorly treated effluent was easily diluted by the river flow and the inflow of seawater. Many people were concerned about eutrophication, therefore, because of the decreased functioning of the wastewater plant in Matsushima Bay. Marked eutrophication in the bay was not observed after August 2011.
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- 2021
4. Implementation of active direction-pass filter on dynamically reconfigurable processor.
- Author
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Shunsuke Kurotaki, Noriaki Suzuki, Kazuhiro Nakadai, Hiroshi G. Okuno, and Hideharu Amano
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- 2005
- Full Text
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5. Performance Evaluation of Instruction Set Architecture of MBP-Light: A Distributed Memory Controller for a Large Scale Multiprocessor.
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Noriaki Suzuki and Hideharu Amano
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- 2003
6. Analysis of microvascular density in early gastric carcinoma using magnifying endoscopy with narrow-band imaging
- Author
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Masashi Kawamura, Hiroshi Naganuma, Rie Shibuya, Tatsuya Kikuchi, Yoshitaka Sakai, Futoshi Nagasaki, Eiki Nomura, Noriaki Suzuki, and Eri Saito
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and study aims: Intramucosal vascular density differs between differentiated and undifferentiated type gastric carcinomas. This study aimed to evaluate the microvascular density characteristics of these two types of carcinoma using magnifying endoscopy with narrow-band imaging (ME-NBI). Patients and methods: In total, 42 differentiated and 10 undifferentiated types were evaluated. The microvessels observed using ME-NBI were extracted from stored still images and the microvascular density in the two carcinoma types was analyzed. Histological vascular density in resected specimens was also evaluated using CD34 immunostaining. Results: There were significant differences between the microvascular density in the differentiated and undifferentiated types of carcinoma (10.02 ± 4.72 % vs 4.02 ± 0.40 %; P
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- 2016
- Full Text
- View/download PDF
7. Clinical practice of acute pancreatitis in Japan: An analysis of nationwide epidemiological survey in 2016
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Atsushi Masamune, Kazuhiro Kikuta, Shin Hamada, Ichiro Tsuji, Yoshifumi Takeyama, Tooru Shimosegawa, Kazuichi Okazaki, Ryotaro Matsumoto, Kiyoshi Kume, Shin Miura, Tetsuya Takikawa, Seiji Hongo, Yu Tanaka, Toshitaka Sakai, Masayuki Ueno, Jun Unno, Masao Toki, Mamoru Nishimura, Katsuya Kitamura, Kasen Kobashigawa, Kiyoshi Ashida, Kuniyuki Takahashi, Takashi Watanabe, Yuichirou Sato, Akihiko Satoh, Naoki Yoshida, Kei Tanaka, Hiromu Kondo, Noriaki Suzuki, Hiroko Sato, Akira Mitoro, Kazuhiro Minami, Eisuke Iwasaki, Kosuke Okuwaki, Tsuyoshi Mukai, Yasushi Kudo, Shunjiro Azuma, Yasuhito Takeda, Morimichi Setsuda, Kohei Tsuchida, Atsushi Irisawa, Daisuke Motoya, Nakao Shirahata, Keisuke Iwata, Noriko Oza, Yasunori Kawaguchi, Atsumi Hoshino, Atsuyuki Hirano, Ichiro Sakakihara, Noriko Watanabe, Hiroyuki Funayama, Yuji Nakamura, Tatuo Yamamoto, H.Hiroshi Uchida, Yusuke Iizawa, Mahiro Imamura, Masanari Sekine, Kazuo Inui, Satoshi Yamamoto, Syuichi Sato, Shuji Ishii, Takayuki Yakushijin, Katsutoshi Yamamoto, Tomohiro Masaka, Motoyuki Yoshida, Toshihiko Arizumi, Manabu Goto, Mamoru Takenaka, Hiroyuki Miyakawa, Yuichiro Otsuka, Masaaki Nishi, Kanetoshi Suwa, Junichi Sakagami, Masahiro Satoh, Hideaki Koga, Tadayuki Takagi, Masatsugu Nagahama, Katsuko Hatayama, Naoya Kaneko, Masafumi Mori, Yousuke Nakai, Yuji Iwashita, Kunio Iwatsuka, Kazunao Hayashi, Shuji Terai, Hiroyuki Kaneto, Takao Nishikawa, Midori Uchi, Mitsuyoshi Honjo, Tomofumi Takagi, Kazuhiro Mizukami, Tetsuo Tamura, Toshifumi Gushima, Ai Sato, Kyoko Shimizu, Yukio Aruga, Kouji Nonogaki, Miyuki Kaino, Takuji Iwashita, Mio Tsuruoka, Masato Miura, Hirofumi Hasegawa, Tetsunari Takai, Hiroyuki Yokota, Toshio Fujisawa, Kota Uetsuki, Takashi Kobayashi, Naohisa yamaji, Takao Itoi, Takashi Muraki, Takayuki Watanabe, Osamu Inatomi, Tomoyuki Ushijima, Yusuke Takehara, Hiroshi Kawamura, Mitsuharu Fukasawa, Hideki Hagiwara, Hiroyuki Tamura, Takashi Moriya, Masaki Kuwatani, Yuki Kawaji, Terumi Kamisawa, Makoto Abue, Masanori Fukunishi, Hirohiko Onoyama, Satoshi Mochizuki, Kimi Sumimoto, Masanori Koyabu, Akiyoshi Nishio, Masayuki Sakao, Yoshiki Imamura, Hajime Ohta, Naruo Nishimura, Masahiro Shiihara, Hideaki Anan, Masayo Motoya, Mitsuru Chiba, Tomohiro Deguchi, Yasuhide Kofunato, Naoya Sawada, Kazuhiro Katada, Shimpei Matsumoto, Syunichi Higashide, Hiroyuki Okano, Masaharu Ishida, Masato Yamazaki, Naoshi Tamura, Takeshi Muraoka, Norimitsu Uza, Yuzo Kodama, Shinichiro Muro, Nao Fujimori, Takaaki Ikeda, Naoto Shimokawahara, Naoya Otsu, Yoichi Yano, Shuichiro Sugawara, Kenta Takaura, Yasuhiro Ogura, Takayuki Furuuchi, Masayuki Shibasaki, and Masanobu Kishimoto
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Adult ,Male ,medicine.medical_specialty ,Carbapenem ,Endocrinology, Diabetes and Metabolism ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Internal medicine ,Epidemiology ,medicine ,Humans ,Aged ,Aged, 80 and over ,Hepatology ,business.industry ,Incidence ,Incidence (epidemiology) ,Gastroenterology ,Gallstones ,Middle Aged ,medicine.disease ,Clinical Practice ,Parenteral nutrition ,Pancreatitis ,030220 oncology & carcinogenesis ,Etiology ,Acute pancreatitis ,Female ,030211 gastroenterology & hepatology ,business ,medicine.drug - Abstract
Background To provide updates on clinical practice of acute pancreatitis (AP) in Japan, we conducted a nationwide epidemiological survey. Methods This study consisted of a two-staged survey; the number of AP patients was estimated by the first-stage survey and their clinical features were examined by the second-stage survey. We surveyed AP patients who had visited hospitals in 2016. Results The estimated number of AP patients in 2016 was 78,450, with an overall incidence of 61.8 per 100,000 persons. We obtained detailed clinical information of 2994 AP patients, including 706 (23.6%) severe cases classified according to the Japanese severity criteria. The male-to-female sex ratio was 2.0, and the mean age at onset was 59.9 years in males and 66.5 years in females. Alcohol was the most common etiology (42.8%) in males and gallstones in females (37.7%). The AP-associated mortality was 6.1% in severe AP cases, which was decreased by 40% compared to the 2011 survey. Antibiotics were administered to most cases, with carbapenem being frequently used. Enteral nutrition was given in 31.8% of severe cases, but majority cases received after 48 h. Among the 107 patients who received intervention for walled-off necrosis, five patients received surgery-first approach, 66 received endoscopic ultrasound-guided transluminal drainage, and 19 underwent step-up approach. Conclusions We clarified the current status of AP in Japan including the significant reduction of mortality in severe cases, shift to endoscopic approaches for walled-off necrosis, and poor compliance of the recommendations in the guidelines including management of enteral nutrition and antibiotic administration.
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- 2020
8. Interpolation Polynomials of Entire Functions for Erdös-Type Weights
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Gou Nakamura, Ryozi Sakai, and Noriaki Suzuki
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Mathematics ,QA1-939 - Published
- 2013
- Full Text
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9. Implementing and Evaluating Stream Applications on the Dynamically Reconfigurable Processor.
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Noriaki Suzuki, Shunsuke Kurotaki, Masayasu Suzuki, Naoto Kaneko, Yutaka Yamada, Katsuaki Deguchi, Yohei Hasegawa, Hideharu Amano, Kenichiro Anjo, Masato Motomura, Kazutoshi Wakabayashi, Takeo Toi, and Toru Awashima
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- 2004
- Full Text
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10. Uniform convergence of orthogonal polynomial expansions for exponential weights
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Ryozi Sakai, Noriaki Suzuki, and Kentaro Itoh
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41A17 ,General Mathematics ,Uniform convergence ,Function (mathematics) ,Interval (mathematics) ,Nonnegative function ,weighted polynomial approximation ,Erdős type weight ,Nikolskii-type inequality ,Exponential function ,Combinatorics ,Orthogonal polynomials ,Bounded variation ,41A10 ,uniformly convergence of Fourier series ,Fourier series ,de la Vallée Poussin mean ,Mathematics - Abstract
We consider an exponential weight $w(x) = \exp(-Q(x))$ on ${\mathbb R} = (-\infty,\infty)$, where $Q$ is an even and nonnegative function on ${\mathbb R}$. We always assume that $w$ belongs to a relevant class $\mathcal{F}(C^2+)$. Let $\{p_n\}$ be orthogonal polynomials for a weight $w$. For a function $f$ on ${\mathbb R}$, $s_n(f)$ denote the $(n-1)$-th partial sum of Fourier series. In this paper, we discuss uniformly convergence of $s_n(f)$ under the conditions that $f$ is continuous and has a bounded variation on any compact interval of ${\mathbb R}$. In the proof of main theorem, Nikolskii-type inequality and boundedness of the de la Vall{\'{e}}e Poussin mean of $f$ play important roles.
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- 2019
11. $L^p$-boundedness of Bergman projections for $\alpha$-parabolic operators
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Katsunori Shimomura, Masaharu Nishio, and Noriaki Suzuki
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Mathematics::Functional Analysis ,Pure mathematics ,Mathematics::Complex Variables ,reproducing kernel ,Alpha (ethology) ,Huygens property ,parabolic operator of fractional order ,31B10 ,35K05 ,Bergman space ,Bergman projection ,46E15 ,Mathematics - Abstract
We consider the $\alpha$-parabolic Bergman spaces on strip domains. The Bergman kernel is given by a series of derivatives of the fundamental solution. We prove the $L^p$-boundedness of the projection defined by the Bergman kernel and obtain the duality theorem for $1 \lt p \lt \infty$. At the same time, we give a new proof of the Huygens property, which enable us to verify all the results in [3] also for $n = 1$.
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- 2019
12. Exponentially weighted Polynomial approximation for absolutely continuous functions
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Ryozi Sakai, Noriaki Suzuki, and Kentaro Itoh
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Combinatorics ,Polynomial (hyperelastic model) ,Section (fiber bundle) ,Erdös type weight ,41A17 ,General Mathematics ,41A10 ,Absolute continuity ,absolutely continuous function ,de la Vallée Poussin mean ,weighted polynomial approximation ,Mathematics - Abstract
We discuss a polynomial approximation on $\mathbb{R}$ with a weight $w$ in $\mathcal{F}(C^{2} +)$ (see Section 2). The de la Vallee Poussin mean $v_n(f)$ of an absolutely continuous function $f$ is not only a good approximation polynomial of $f$, but also its derivatives give an approximation for the derivative $f'$. More precisely, for $1 \leq p \leq \infty$, we have $\lim_{n \rightarrow \infty}\|(f - v_{n}(f))w\|_{L^{p}(\mathbb{R})} =0$ and $\lim_{n \rightarrow \infty}\|(f' - v_{n}(f)')w\|_{L^{p}(\mathbb{R})} =0$ whenever $f''w \in L^{p}(\mathbb{R})$.
- Published
- 2018
13. Carleson inequalities on parabolic Hardy spaces
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Noriaki Suzuki and Hayato Nakagawa
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Mathematics::Functional Analysis ,parabolic operator ,Mathematics::Complex Variables ,General Mathematics ,Mathematical analysis ,Mathematics::Classical Analysis and ODEs ,Hardy space ,31B25 ,Carleson measure ,symbols.namesake ,35J05 ,symbols ,Carleson inequality ,Mathematics - Abstract
We study Carleson inequalities in a framework of parabolic Hardy spaces. Similar results for parabolic Bergman spaces are discussed in [NSY1] (see also [NSY2]), where $\tau$-Carleson measures play an important roll. In the present case, $T_{\tau}$-Carleson measures are useful. We give an relation between these measures.
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- 2017
14. A Parabolic Approach to Martin Boundaries for Elliptic Equations in Skew Product Form
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Minoru Murata and Noriaki Suzuki
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Mathematics::Logic ,Elliptic curve ,Class (set theory) ,Integral representation ,Elliptic partial differential equation ,Product (mathematics) ,Mathematical analysis ,Skew ,Parabolic partial differential equation ,Analysis ,Potential theory ,Mathematics - Abstract
We consider positive solutions of elliptic partial differential equations on non-compact domains of Riemannian manifolds. We explicitly determine Martin compactifications and Martin kernels for a wide class of elliptic equations in skew product form by exploiting parabolic Martin kernels for associated parabolic equations.
- Published
- 2013
15. Connexins Regulate Cell Functions in Pancreatic Stellate Cells
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Shin Hamada, Tooru Shimosegawa, Tetsuya Takikawa, Noriaki Suzuki, Kiyoshi Kume, Atsushi Kanno, Shintaro Hayashi, Morihisa Hirota, Kazuhiro Kikuta, Michiaki Unno, Shinichi Egawa, Hiroyuki Ariga, and Atsushi Masamune
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Male ,Pathology ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Blotting, Western ,Cell ,Becaplermin ,Fluorescent Antibody Technique ,Biology ,Real-Time Polymerase Chain Reaction ,Collagen Type I ,Connexins ,Endocrinology ,Cell Movement ,Pancreatitis, Chronic ,Pancreatic cancer ,Internal Medicine ,medicine ,Animals ,Humans ,RNA, Messenger ,RNA, Small Interfering ,Rats, Wistar ,Myofibroblasts ,Cells, Cultured ,Cell Proliferation ,Dose-Response Relationship, Drug ,Hepatology ,Reverse Transcriptase Polymerase Chain Reaction ,Cell growth ,Pancreatic Stellate Cells ,Gap junction ,Proto-Oncogene Proteins c-sis ,medicine.disease ,Fibrosis ,Rats ,Cell biology ,Pancreatic Neoplasms ,medicine.anatomical_structure ,Connexin 43 ,Carbenoxolone ,Hepatic stellate cell ,Pancreatitis ,RNA Interference ,Myofibroblast ,Intracellular - Abstract
Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis associated with chronic pancreatitis and pancreatic cancer. Connexins (Cxs) allow direct intercellular communications as components of gap junction but also play important roles in the regulation of cell proliferation, cell differentiation, and tissue development. We here examined the expression of Cxs and Cx-mediated regulation of cell functions in PSCs.Human PSCs were isolated from patients undergoing operation for chronic pancreatitis or pancreatic cancer. The expression of Cxs was examined by reverse transcription polymerase chain reaction, Western blotting, and immunofluorescent staining. The roles of Cxs in PSC functions were examined by using carbenoxolone, a broad-spectrum Cx inhibitor, and small interfering RNA for Cx43.Human activated PSCs expressed a variety of Cxs including Cx43 both in vitro and in vivo. Carbenoxolone inhibited platelet-derived growth factor-BB-induced proliferation and migration, and type I collagen expression in PSCs. In addition, carbenoxolone inhibited the activation of quiescent PSCs to a myofibroblastlike phenotype. Decreased Cx43 expression by small interfering RNA resulted in decreased proliferation and type I collagen expression.Pancreatic stellate cells expressed a variety of Cxs. Connexins, especially Cx43, might regulate the cell functions and activation of PSCs.
- Published
- 2013
16. Analysis of microvascular density in early gastric carcinoma using magnifying endoscopy with narrow-band imaging
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Futoshi Nagasaki, Rie Shibuya, Masashi Kawamura, Eiki Nomura, Yoshitaka Sakai, Tatsuya Kikuchi, Eri Saito, Noriaki Suzuki, and Hiroshi Naganuma
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Pathology ,medicine.medical_specialty ,Original article ,Narrow-band imaging ,business.industry ,Magnifying endoscopy ,CD34 ,Microvascular Density ,Gastric carcinoma ,Anatomy ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Close relationship ,030220 oncology & carcinogenesis ,Carcinoma ,Medicine ,030211 gastroenterology & hepatology ,Pharmacology (medical) ,lcsh:Diseases of the digestive system. Gastroenterology ,lcsh:RC799-869 ,business ,Immunostaining - Abstract
Background and study aims: Intramucosal vascular density differs between differentiated and undifferentiated type gastric carcinomas. This study aimed to evaluate the microvascular density characteristics of these two types of carcinoma using magnifying endoscopy with narrow-band imaging (ME-NBI). Patients and methods: In total, 42 differentiated and 10 undifferentiated types were evaluated. The microvessels observed using ME-NBI were extracted from stored still images and the microvascular density in the two carcinoma types was analyzed. Histological vascular density in resected specimens was also evaluated using CD34 immunostaining. Results: There were significant differences between the microvascular density in the differentiated and undifferentiated types of carcinoma (10.02 ± 4.72 % vs 4.02 ± 0.40 %; P
- Published
- 2016
17. Convergence and Divergence of Higher-Order Hermite or Hermite-Fejér Interpolation Polynomials with Exponential-Type Weights
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Gou Nakamura, Hee Sun Jung, Ryozi Sakai, and Noriaki Suzuki
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Combinatorics ,Classical orthogonal polynomials ,Mathematical optimization ,Hermite spline ,Hermite polynomials ,Article Subject ,Difference polynomials ,Hermite interpolation ,Discrete orthogonal polynomials ,Orthogonal polynomials ,Birkhoff interpolation ,Mathematics - Abstract
Let ℝ = ( − ∞ , ∞ ) , and let 𝑤 𝜌 ( 𝑥 ) = | 𝑥 | 𝜌 𝑒 − 𝑄 ( 𝑥 ) , where 𝜌 > − 1 / 2 and 𝑄 ∈ 𝐶 1 ( ℝ ) ∶ ℝ → ℝ + = [ 0 , ∞ ) is an even function. Then we can construct the orthonormal polynomials 𝑝 𝑛 ( 𝑤 2 𝜌 ; 𝑥 ) of degree 𝑛 for 𝑤 2 𝜌 ( 𝑥 ) . In this paper for an even integer 𝜈 ≥ 2 we investigate the convergence theorems with respect to the higher-order Hermite and Hermite-Fejér interpolation polynomials and related approximation process based at the zeros { 𝑥 𝑘 , 𝑛 , 𝜌 } 𝑛 𝑘 = 1 of 𝑝 𝑛 ( 𝑤 2 𝜌 ; 𝑥 ) . Moreover, for an odd integer 𝜈 ≥ 1 , we give a certain divergence theorem with respect to the higher-order Hermite-Fejér interpolation polynomials based at the zeros { 𝑥 𝑘 , 𝑛 , 𝜌 } 𝑛 𝑘 = 1 of 𝑝 𝑛 ( 𝑤 2 𝜌 ; 𝑥 ) .
- Published
- 2012
18. Do genetic variants in the SPINK1 gene affect the level of serum PSTI?
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Noriaki Suzuki, Shintaro Hayashi, Kazuhiro Kikuta, Morihisa Hirota, Atsushi Masamune, Kiyoshi Kume, Tooru Shimosegawa, Hiroyuki Ariga, Shin Miura, Tetsuya Takikawa, Shin Hamada, and Atsushi Kanno
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Adult ,Male ,Adolescent ,Radioimmunoassay ,medicine.disease_cause ,Sensitivity and Specificity ,Young Adult ,PstI ,Recurrence ,Polymorphism (computer science) ,Pancreatitis, Chronic ,medicine ,Humans ,Missense mutation ,Child ,Pancreatic Secretory Trypsin Inhibitor ,Aged ,Serine protease ,Mutation ,biology ,business.industry ,Gastroenterology ,Genetic Variation ,Middle Aged ,medicine.disease ,Molecular biology ,Pancreatitis ,Trypsin Inhibitor, Kazal Pancreatic ,Case-Control Studies ,Child, Preschool ,Acute Disease ,biology.protein ,Female ,Carrier Proteins ,business - Abstract
The serine protease inhibitor Kazal type 1 (SPINK1), also known as pancreatic secretory trypsin inhibitor (PSTI), is a peptide secreted by pancreatic acinar cells. Genetic studies have shown an association between SPINK1 gene variants and chronic pancreatitis or recurrent acute pancreatitis. The aim of this study was to clarify whether the SPINK1 variants affect the level of serum PSTI.One hundred sixty-three patients with chronic pancreatitis or recurrent acute pancreatitis and 73 healthy controls were recruited. Serum PSTI concentrations were determined with a commercial radioimmunoassay kit.Ten patients with the p.N34S variant, 7 with the IVS3+2TC variant, two with both the p.N34S and the IVS3+2TC variants, and one with the novel missense p.P45S variant in the SPINK1 gene were identified. The serum PSTI level in patients with no SPINK1 variants was 14.3 ± 9.6 ng/ml (mean ± SD), and that in healthy controls was 10.7 ± 2.2 ng/ml. The PSTI level in patients carrying the IVS3+2TC variant (5.1 ± 3.4 ng/ml), but not in those with the p.N34S variant (8.9 ± 3.5 ng/ml), was significantly lower than that in the patients without the SPINK1 variants and the healthy controls. The serum PSTI level in the patient with the p.P45S variant was 4.9 ng/ml. Low levels of serum PSTI (6.0 ng/ml) showed sensitivity of 80 %, specificity of 97 %, and accuracy of 96 % in the differentiation of IVS3+2TC and p.P45S carriers from non-carriers.Serum PSTI levels were decreased in patients with the IVS3+2TC and p.P45S variants of the SPINK1 gene.
- Published
- 2012
19. On the Favard-Type Theorem and the Jackson-Type Theorem (II)
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Ryozi Sakai, Noriaki Suzuki, and Hee Sun Jung
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Pure mathematics ,Article Subject ,Modulus of smoothness ,Computer Science::Information Retrieval ,Even and odd functions ,Type (model theory) ,Minkowski inequality ,Equivalence (measure theory) ,Mathematics ,Exponential function - Abstract
Let R = ( − ∞ , ∞ ) , and let 𝑄 ∈ ℂ 1 ∶ ℝ → [ 0 , ∞ ) be an even function. We consider the exponential weights 𝑤 ( 𝑥 ) = 𝑒 − 𝑄 ( 𝑥 ) , 𝑥 ∈ ℝ . In this paper we investigate the relations between the Favard-type inequality and the Jackson-type inequality. We also discuss the equivalence of two K-functionals and the modulus of smoothness.
- Published
- 2011
20. Carleson inequalities on parabolic Bergman spaces
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Masaharu, Nishio, Noriaki, Suzuki, and Masahiro, Yamada
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Mathematics::Functional Analysis ,Mathematics::Complex Variables ,Mathematics::Classical Analysis and ODEs - Abstract
We study Carleson inequalities on parabolic Bergman spaces on the upper half space of the Euclidean space. We say that a positive Borel measure satisfies a $(p,q)$-Carleson inequality if the Carleson inclusion mapping is bounded, that is, $q$-th order parabolic Bergman space is embedded in $p$-th order Lebesgue space with respect to the measure under considering. In a recent paper [6], we estimated the operator norm of the Carleson inclusion mapping for the case $q$ is greater than or equal to $p$. In this paper we deal with the opposite case. When $p$ is greater than $q$, then a measure satisfies a $(p,q)$-Carleson inequality if and only if its averaging function is $\sigma$-th integrable, where $\sigma$ is the exponent conjugate to $p/q$. An application to Toeplitz operators is also included.
- Published
- 2010
21. Effects of Ethanol and Its Metabolites on Human Pancreatic Stellate Cells
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Kennichi Satoh, Atsushi Masamune, Masahiro Satoh, Noriaki Suzuki, Akihiko Satoh, Takashi Watanabe, Tooru Shimosegawa, and Kazuhiro Kikuta
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medicine.medical_specialty ,Physiology ,Palmitates ,Acetaldehyde ,Palmitic acid ,chemistry.chemical_compound ,Internal medicine ,medicine ,Humans ,Lipase ,Protein kinase A ,Pancreas ,Cells, Cultured ,Cell Proliferation ,Mitogen-Activated Protein Kinase Kinases ,chemistry.chemical_classification ,Triglyceride lipase ,Ethanol ,biology ,Interleukin-8 ,NF-kappa B ,Gastroenterology ,Fatty acid ,Peptide Fragments ,Transcription Factor AP-1 ,Endocrinology ,chemistry ,Biochemistry ,biology.protein ,Hepatic stellate cell ,Collagen ,Procollagen - Abstract
Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic inflammation and fibrosis. In the pancreas, in addition to oxidative metabolism, ethanol can be metabolized by esterification with fatty acids to form fatty acid ethyl esters such as palmitic acid ethyl ester (PAEE). We here examined the effects of ethanol (at 20 or 50 mM), acetaldehyde (at 200 microM), or PAEE (at 100 microM), on PSCs functions. PSCs did not express mRNAs for pancreatic triglyceride lipase and carboxyl ester lipase. Ethanol and acetaldehyde, but not PAEE, induced production of procollagen type I C-peptide. Ethanol, but not acetaldehyde or PAEE, induced interleukin-8 production. PAEE activated activator protein-1, but not nuclear factor kappaB. In addition, PAEE activated extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. Specific activation of signal transduction pathways and cell functions by ethanol and its metabolites may play a role in alcohol-induced pancreatic injury.
- Published
- 2009
22. Adsorption of genetically engineered proteins studied by time-of-flight secondary ion mass spectrometry (TOF-SIMS). Part A: data acquisition and principal component analysis (PCA)
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Noriaki Suzuki, Lara J. Gamble, Mehmet Sarikaya, Fumio S. Ohuchi, Candan Tamerler, and David G. Castner
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chemistry.chemical_classification ,Chemistry ,Binding protein ,Analytical chemistry ,Combinatorial biology ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Combinatorial chemistry ,Surfaces, Coatings and Films ,Amino acid ,Secondary ion mass spectrometry ,Adsorption ,Principal component analysis ,Materials Chemistry ,Binding site ,Binding selectivity - Abstract
Recent progress in the adaptation of combinatorial biology selection protocols to materials science has created a new class of polypeptides with specific affinity to inorganics. Here, we use one of the genetically engineered proteins, a gold binding protein (GBP-1), to assess quantitatively its binding specificity to Au, Ag and Pd surfaces by using time-of-flight secondary ion mass spectroscopy (TOF-SIMS). The GBP-1, originally selected using cell-surface display techniques, consisting of 14 amino acids with a sequence of MHGKTQATSGTIQS, was used in this study. Three-repeat and single-repeat forms of GBP-1 were prepared. In earlier studies, GBP-1 was shown to bind to Au particles and self-assemble on flat Au surfaces. Through the fingerprint analysis of these specific peptides, their role in binding can be investigated in terms of their contribution to surface interaction possibly forming the right molecular architecture for binding. To achieve this purpose, a large-sized data matrix produced by TOF-SIMS must be properly treated for analysis. In Part A, we use principal component analysis (PCA) to visualize the spectral variations for a variety of adsorption conditions and suggest possible contribution of the specific types of amino acids (binding site) to the interactions. Copyright © 2007 John Wiley & Sons, Ltd.
- Published
- 2007
23. Adsorption of genetically engineered proteins studied by time-of-flight secondary ion mass spectrometry (TOF-SIMS). Part B: hierarchical cluster analysis (HCA)
- Author
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Mehmet Sarikaya, Fumio S. Ohuchi, and Noriaki Suzuki
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Chemistry ,Genetically engineered ,Analytical chemistry ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Hierarchical clustering ,Secondary ion mass spectrometry ,Time of flight ,Adsorption ,Similarity (network science) ,Principal component analysis ,Materials Chemistry ,Multivariate statistical - Abstract
In Part A, we adopted principal component analysis (PCA) for the analysis of TOF-SIMS data to assess the binding specificity of GBP-1 to metallic Au, Ag and Pd. Within a given set of data, PCA aids in the interpretation of the TOF-SIMS spectra by capitalizing on the differences from one spectrum to another. In Part B, we introduce another multivariate statistical method called ‘hierarchical cluster analysis (HCA)’, where visualization of the similarity and difference in data is readily observed, from which a variety of adsorption conditions of GBP-1 were characterized. Copyright © 2007 John Wiley & Sons, Ltd.
- Published
- 2007
24. [Two cases of squamoid cyst of the pancreatic ducts]
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Takayoshi, Meguro, Sayaka, Hasekura, Shiho, Kondo, Yoshifumi, Matsumura, Noriaki, Suzuki, Kyoko, Utsunomiya, Makoto, Yonechi, Takeshi, Yamamoto, Ryuji, Nakamura, and Kazuhiro, Murakami
- Subjects
Male ,CA-19-9 Antigen ,Pancreatic Ducts ,Middle Aged ,Magnetic Resonance Imaging ,Multimodal Imaging ,Carcinoembryonic Antigen ,Diagnosis, Differential ,Pancreatic Neoplasms ,Pancreatectomy ,Positron-Emission Tomography ,Humans ,Female ,Pancreatic Cyst ,Tomography, X-Ray Computed ,Aged - Abstract
Two patients were referred to our hospital with cystic lesion (diameter 5 cm) of the pancreas and elevated serum CEA and CA19-9. We diagnosed them with malignant cystic neoplasms of the pancreas and performed distal pancreatectomy. Histologically, in both cases the cysts were lined with flat, transitional, squamoid cells without keratinization. Immunohistochemical staining confirmed two rare cases of squamoid cyst of the pancreatic ducts.
- Published
- 2015
25. The de la Vallée Poussin Mean and Polynomial Approximation for Exponential Weight
- Author
-
Noriaki Suzuki, Kentaro Itoh, and R. Sakai
- Subjects
Combinatorics ,Polynomial ,Article Subject ,Mathematics - Classical Analysis and ODEs ,lcsh:Mathematics ,Classical Analysis and ODEs (math.CA) ,FOS: Mathematics ,41A17(Primary), 41A10(Secondary) ,lcsh:QA1-939 ,Exponential function ,Mathematics - Abstract
We study Lp boundedness of the de la Vallée Poussin means vn(f) for exponential weight w(x)=exp(-Q(x)) on R. Our main result is vn(f)(w/T1/4)Lp(R)≤C∥fw∥Lp(R), for every n∈N and every 1≤p≤∞, where T(x)=xQ′(x)/Q(x). As an application, we obtain limn→∞(f-vn(f))w/T1/4Lp(R)=0 for fw∈Lp(R).
- Published
- 2015
26. Curcumin blocks activation of pancreatic stellate cells
- Author
-
Noriaki Suzuki, Masahiro Satoh, Kazuhiro Kikuta, Kennichi Satoh, Atsushi Masamune, and Tooru Shimosegawa
- Subjects
Male ,MAPK/ERK pathway ,Curcumin ,Cell Survival ,p38 mitogen-activated protein kinases ,Biochemistry ,chemistry.chemical_compound ,Animals ,Rats, Wistar ,Extracellular Signal-Regulated MAP Kinases ,Pancreas ,Molecular Biology ,Cells, Cultured ,Chemokine CCL2 ,Cell Proliferation ,Platelet-Derived Growth Factor ,Dose-Response Relationship, Drug ,Ethanol ,biology ,Kinase ,NF-kappa B ,Cell Differentiation ,Cell Biology ,Actins ,Rats ,Cell biology ,Transcription Factor AP-1 ,chemistry ,Mitogen-activated protein kinase ,biology.protein ,Hepatic stellate cell ,Collagen ,Signal transduction ,Platelet-derived growth factor receptor ,Signal Transduction - Abstract
Activated pancreatic stellate cells (PSCs) play a pivotal role in the pathogenesis of pancreatic fibrosis and inflammation. Inhibition of activation and cell functions of PSCs is a potential target for the treatment of pancreatic fibrosis and inflammation. The polyphenol compound curcumin is the yellow pigment in curry, and has anti-inflammatory and anti-fibrotic properties. We here evaluated the effects of curcumin on the activation and cell functions of PSCs. PSCs were isolated from rat pancreas tissue and used in their culture-activated, myofibroblast-like phenotype unless otherwise stated. The effects of curcumin on proliferation, alpha-smooth muscle actin gene expression, monocyte chemoattractant protein (MCP)-1 production, and collagen expression were examined. The effect of curcumin on the activation of freshly isolated cells in culture was also assessed. Curcumin inhibited platelet-derived growth factor (PDGF)-induced proliferation, alpha-smooth muscle actin gene expression, interleukin-1beta- and tumor necrosis factor (TNF)-alpha-induced MCP-1 production, type I collagen production, and expression of type I and type III collagen genes. Curcumin inhibited PDGF-BB-induced cyclin D1 expression and activation of extracellular signal-regulated kinase (ERK). Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB). In addition, curcumin inhibited transformation of freshly isolated cells to myofibroblast-like phenotype. In conclusion, curcumin inhibited key cell functions and activation of PSCs.
- Published
- 2006
27. Ellagic acid blocks activation of pancreatic stellate cells
- Author
-
Atsushi Masamune, Kennichi Satoh, Noriaki Suzuki, Tooru Shimosegawa, Kazuhiro Kikuta, and Masahiro Satoh
- Subjects
Male ,Blotting, Western ,Becaplermin ,Electrophoretic Mobility Shift Assay ,Biology ,Polymerase Chain Reaction ,Biochemistry ,chemistry.chemical_compound ,Ellagic Acid ,Cell Movement ,Animals ,Phosphorylation ,Rats, Wistar ,Protein kinase A ,Pancreas ,Protein kinase B ,Cells, Cultured ,Chemokine CCL2 ,Cell Proliferation ,DNA Primers ,Platelet-Derived Growth Factor ,Pharmacology ,Base Sequence ,Kinase ,Tyrosine phosphorylation ,Proto-Oncogene Proteins c-sis ,Rats ,Cell biology ,chemistry ,biology.protein ,Hepatic stellate cell ,Signal transduction ,Platelet-derived growth factor receptor ,Ellagic acid - Abstract
Activated pancreatic stellate cells (PSCs) play a pivotal role in the pathogenesis of pancreatic fibrosis and inflammation. Ellagic acid is a plant-derived polyphenol found in fruits and nuts, and has anti-oxidant and anti-inflammatory properties. But, little is known about the effects of ellagic acid on PSCs as well as on the activation of signal transduction pathways. We here evaluated the effects of ellagic acid on the activation and cell functions of PSCs. PSCs were isolated from rat pancreas tissue and used in their culture-activated, myofibroblast-like phenotype unless otherwise stated. Ellagic acid inhibited platelet-derived growth factor (PDGF)-BB-induced proliferation and migration, interleukin (IL)-1beta- and tumor necrosis factor (TNF)-alpha-induced monocyte chemoattractant protein-1 production, and expression of alpha-smooth muscle actin and collagen genes. Ellagic acid inhibited PDGF-BB-induced tyrosine phosphorylation of PDGF beta-receptor and the downstream activation of extracellular signal-regulated kinase and Akt. Ellagic acid inhibited IL-1beta- and TNF-alpha-induced activation of activator protein-1 and mitogen-activated protein kinases (extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38 mitogen-activated protein kinase), but not of nuclear factor-kappaB. In addition, ellagic acid inhibited transformation of freshly isolated cells to an activated, myofibroblast-like phenotype. In conclusion, ellagic acid inhibited key cell functions and activation of PSCs.
- Published
- 2005
28. High Sustained Virologic Response Rate after Interferon Monotherapy in Japanese Hepatitis C Patients with a Low HCV RNA Titer and/or HCV Genotype 2
- Author
-
Nobuaki Gotou, Akira Hayasaka, Yasuo Hirai, Tatsuo Kanda, Michio Kimura, Shosuke Iwama, Fumio Imazeki, Osamu Yokosuka, Kenichi Fukai, Motohide Takashi, Shinichi Hino, Katsuo Uchiumi, Hiromitsu Saisho, Shigenobu Kawai, and Noriaki Suzuki
- Subjects
business.industry ,Ribavirin ,Hepatitis C virus ,virus diseases ,RNA ,Hepatitis C ,medicine.disease ,medicine.disease_cause ,Virology ,digestive system diseases ,chemistry.chemical_compound ,Titer ,Infectious Diseases ,chemistry ,Interferon ,Genotype ,Medicine ,Prospective cohort study ,business ,medicine.drug - Abstract
Objective: Hepatitis C virus (HCV) RNA titer and HCV genotype are considered to be major determinants of the outcome of interferon monotherapy. To clarify whether interferon monotherapy is really effective in patients with the appropriate viral parameters, we prospectively examined these parameters and treated the patients with interferon monotherapy. Methods: Sixty-four patients with an HCV RNA titer 100 kIU/ml and genotype 1 were also enrolled as controls. All patients were treated with 10 megaunits of interferon-α2b every day for 2 weeks and then 3 times a week for 24 weeks. Results: Of the 64 patients with either HCV RNA 100 kIU/ml and genotype 1 were virologic sustained responders (p < 0.001). Conclusion: Our current study showed that the patients with HCV RNA
- Published
- 2004
29. Diagnostic Problems Caused by HBsAg Mutants – A Consensus Report of an Expert Meeting
- Author
-
Yoshiyuki Suzuki, Sumalee Jindadamrongwech, Lars O. Magnius, Helene Norder, Mohammad Mehaboob Hussain, Luisa Imberti, Shigenobu Kawai, Chetan Datta Poduri, Betty H. Robertson, Fumitaka Suzuki, Osamu Yokosuka, Efraín Garrido, Yasuo Hirai, Yasuji Arase, Vicente Soriano, Elba D. Carrillo, Shinichi Hino, Srinivasan Krishnan, Pierre Coursaget, Salvatore Casari, Mariko Kobayashi, Hiromitsu Saisho, Giampiero di Gennaro, Ettore Bidoli, Stephen Locarnini, Rosamaria Tedeschi, Michio Kimura, Nobuaki Gotou, Madhavi Chandra, Nafeesa Farees, M D'Andrea, Kenji Ikeda, Stefania Zanussi, Maria Teresa Bortolin, Giampiero Carosi, Fumio Imazeki, Hiromitsu Kumada, Hitomi Sezaki, Guntaka Venkata Ramareddy, Akira Hayasaka, Norio Akuta, Paolo De Paoli, Shosuke Iwama, Chiara Pratesi, Silvia Pirovano, Mohammad Nanne Khaja, Masahiro Kobayashi, Noriaki Suzuki, Kenichi Fukai, C M Habibullah, Tatsuo Kanda, Francesca Moretti, Patricio Gariglio, Darron R. Brown, Mohammad Aejaz Habeeb, Motohide Takashi, Eugenia Quiros-Roldan, José M. Echevarría, Carlo Torti, Katsuo Uchiumi, Elizabeth E. Lehr, Isa K. Mushahwar, Akihito Tsubota, Shou-Dong Lee, Anne-Marie Couroucé, Satoshi Saitoh, Takashi Someya, Calla R. Brown, Tetsuya Hosaka, and Duncan R. Smith
- Subjects
HBsAg ,Infectious Diseases ,business.industry ,Virology ,Mutant ,Medicine ,business - Published
- 2004
30. Retinal findings in systemic sclerosis: a comparison with nailfold capillaroscopic patterns
- Author
-
Osamu Ushiyama, Syuichi Koarada, Akihide Ohta, Kohei Nagasawa, Yoshifumi Tada, K Ushiyama, Noriaki Suzuki, and T Yamada
- Subjects
Male ,Systemic disease ,medicine.medical_specialty ,Pathology ,Eye disease ,Immunology ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Retinal Diseases ,Rheumatology ,Ophthalmology ,medicine ,Humans ,Immunology and Allergy ,Fluorescein Angiography ,skin and connective tissue diseases ,Scleroderma, Systemic ,integumentary system ,business.industry ,Retinal Vessels ,Retinal ,Middle Aged ,Macular degeneration ,medicine.disease ,Connective tissue disease ,Capillaries ,Extended Report ,Blood pressure ,Nails ,chemistry ,Female ,Complication ,business ,Retinopathy - Abstract
Objective: To determine the prevalence of retinal disease in systemic sclerosis (SSc) and to characterise the findings of retinopathy. Additionally, to analyse the association of retinal disease with other clinical/laboratory findings, particularly the findings of nailfold capillaries in patients with SSc. Methods: Photographs of the ocular fundi were taken and were evaluated by an ophthalmologist who was unaware of the SSc status of the patients. The nailfold capillaries were analysed with a dermatoscope. Patients were divided into two groups according to the presence (group A) or absence (group B) of retinal disease. Results: Retinal findings of the patients with SSc consisted of hard exudates, vascular tortuosity, microhaemorrhage, and macular degeneration. The prevalence of retinal disease among the patients with SSc was 34% (10/29), compared with 8%(3/38) among the controls (p=0.011). The mean systolic blood pressure and the age of the patients in group A were significantly higher than those in group B. However, there was no significant difference in the nailfold capillary damage between groups A and B. Conclusion: Retinal abnormalities are often seen in patients with SSc and they may reflect the vascular changes characteristic of SSc. However, retinal changes may differ in quality from the changes of nailfold capillaries.
- Published
- 2003
31. Mean value densities for temperatures
- Author
-
Noriaki Suzuki and Neil A. Watson
- Subjects
General Mathematics ,Bounded function ,Mean value ,Mathematical analysis ,Zero (complex analysis) ,Mathematics - Abstract
A positive measurable functionK on a domainD inR n+1 is called a mean value density for temperatures if u(0; 0) = D K(x;t)u(x;t)dxdt for all temperatures u on D. We construct such a density for some domains. The existence of a bounded density and a density which is bounded away from zero on D is also discussed.
- Published
- 2003
32. An estimate for derivative of the de la Vallee Poussin mean
- Author
-
Kentaro Itoh, Ryozi Sakai, and Noriaki Suzuki
- Subjects
Christoffel symbols ,Mathematics - Classical Analysis and ODEs ,Mathematics::Classical Analysis and ODEs ,Classical Analysis and ODEs (math.CA) ,FOS: Mathematics ,Applied mathematics ,Function (mathematics) ,Derivative ,41A17(Primary), 41A10(Primary) ,Real line ,Exponential function ,Mathematics - Abstract
In this paper, we discuss derivative of the de la Vallee Poussin mean for exponential weights on real line. When we lead an inequality, an estimate for the Christoffel function plays an important role., Comment: 18 pages
- Published
- 2014
- Full Text
- View/download PDF
33. Collagen-Induced Arthritis in TNF Receptor-1-Deficient Mice: TNF Receptor-2 Can Modulate Arthritis in the Absence of TNF Receptor-1
- Author
-
Fumitaka Morito, Osamu Ushiyama, Tak W. Mak, Syuichi Koarada, Akihide Ohta, Yoshifumi Tada, Noriaki Suzuki, Alexandra Ho, Kohei Nagasawa, and Yuji Kikuchi
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,medicine.medical_treatment ,Immunology ,Arthritis ,macromolecular substances ,Receptors, Tumor Necrosis Factor ,Proinflammatory cytokine ,Mice ,Antigens, CD ,Internal medicine ,medicine ,Animals ,Receptors, Tumor Necrosis Factor, Type II ,Immunology and Allergy ,Receptor ,Interleukin 6 ,biology ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,business.industry ,respiratory system ,medicine.disease ,Cytokine ,Endocrinology ,Mice, Inbred DBA ,Receptors, Tumor Necrosis Factor, Type I ,Immunoglobulin G ,Rheumatoid arthritis ,biology.protein ,Tumor necrosis factor alpha ,Collagen ,Tumor necrosis factor receptor 2 ,business ,Interleukin-1 - Abstract
TNF is a potent proinflammatory cytokine important for the development of arthritis in human and animals. We have investigated the roles of TNF receptor-1 (TNFR1) and TNF receptor-2 (TNFR2) in collagen-induced arthritis (CIA) by inducing CIA in mice genetically deficient in TNFR1. TNFR1-/- mice developed arthritis with similar incidence and severity as TNFR1+/- littermates, indicating that TNFR1 is redundant for the development of CIA. Anti-type II collagen (CII) antibody levels and T cell responses to CII did not differ between TNFR1-/- mice and controls. Neutralization of TNF with soluble TNF binding protein suppressed the development of arthritis in TNFR1+/- mice but not in TNFR1-/- mice, indicating that TNFR2 cannot substitute for TNFR1 for the proinflammatory function. To further investigate the functions of TNFR2, TNFR1-/- mice were injected with murine TNF-alpha at different stages during the course of CIA. Repeated TNF-alpha injection during the early induction phase enhanced the development of arthritis, but inhibited arthritis when administered during the late progression phase. These results show that the engagement of TNFR2 by TNF is involved in the development of CIA in the absence of TNFR1 and that opposing signals can be transduced by TNFR2.
- Published
- 2001
34. A characterization of heat balls by a mean value property for temperatures
- Author
-
Noriaki Suzuki and Neil A. Watson
- Subjects
Identity (mathematics) ,Property (philosophy) ,Volume (thermodynamics) ,Applied Mathematics ,General Mathematics ,Mathematical analysis ,Mean value ,Inverse ,Heat equation ,Characterization (mathematics) ,Mathematics - Abstract
We discuss an inverse mean value property of solutions of the heat equation. We show that, under certain conditions, a volume mean value identity characterizes heat balls.
- Published
- 2001
35. Coordinated Bank and Cache Coloring for Temporal Protection of Memory Accesses
- Author
-
Mark Klein, Ragunathan Rajkumar, Noriaki Suzuki, Dionisio de Niz, Lutz Wrage, Hyoseung Kim, and Björn Andersson
- Subjects
CPU cache ,Cache coloring ,Computer science ,Pipeline burst cache ,Parallel computing ,Cache pollution ,Cache-oblivious algorithm ,Non-uniform memory access ,Write-once ,Cache invalidation ,Cache algorithms ,Snoopy cache ,Hardware_MEMORYSTRUCTURES ,Memory hierarchy ,MESI protocol ,Cache-only memory architecture ,MESIF protocol ,Smart Cache ,Memory bank ,Shared memory ,Bus sniffing ,Virtual memory ,Page cache ,Cache ,Least frequently used ,Dram memory - Abstract
In commercial-off-the-shelf (COTS) multi-core systems, the execution times of tasks become hard to predict because of contention on shared resources in the memory hierarchy. In particular, a task running in one processor core can delay the execution of another task running in another processor core. This is due to the fact that tasks can access data in the same cache set shared among processor cores or in the same memory bank in the DRAM memory (or both). Such cache and bank interference effects have motivated the need to create isolation mechanisms for resources accessed by more than one task. One popular isolation mechanism is cache coloring that divides the cache into multiple partitions. With cache coloring, each task can be assigned exclusive cache partitions, thereby preventing cache interference from other tasks. Similarly, bank coloring allows assigning exclusive bank partitions to tasks. While cache coloring and some bank coloring mechanisms have been studied separately, interactions between the two schemes have not been studied. Specifically, while memory accesses to two different bank colors do not interfere with each other at the bank level, they may interact at the cache level. Similarly, two different cache colors avoid cache interference but may not prevent bank interference. Therefore it is necessary to coordinate cache and bank coloring approaches. In this paper, we present a coordinated cache and bank coloring scheme that is designed to prevent cache and bank interference simultaneously. We also developed color allocation algorithms for configuring a virtual memory system to support our scheme which has been implemented in the Linux kernel. In our experiments, we observed that the execution time can increase by 60% due to inter-task interference when we use only cache coloring. Our coordinated approach can reduce this figure down to 12% (an 80% reduction).
- Published
- 2013
36. Rapid detection of Nocardia amarae in the activated sludge process using enzyme-linked immunosorbent assay (ELISA)
- Author
-
Sachiko Morisada, Noriaki Suzuki, Keisuke Iwahori, and Naoyuki Miyata
- Subjects
Colony-forming unit ,Chromatography ,biology ,Bioengineering ,biology.organism_classification ,Applied Microbiology and Biotechnology ,Nocardiaceae ,Microbiology ,Activated sludge ,Wastewater ,biology.protein ,Sewage treatment ,Actinomycetales ,Antibody ,Bacteria ,Biotechnology - Abstract
Nocardia amarae, a mycolic acid-containing bacterium, has often been reported to cause foaming of activated sludge in wastewater treatment plants. In this study, the number of N. amarae cells in the activated sludge process was estimated by enzyme-linked immunosorbent assay (ELISA) with anti-N. amarae polyclonal antibody. Use of the antibody enabled N. amarae to be detected at levels of 10(4) to 10(7) colony forming units. On the other hand, the antibody reacted with only a small portion of activated sludge, in which no N. amarae cells were detected by the plate count method. Competitive ELISA was employed to estimate the N. amarae cells in samples taken from a municipal wastewater treatment plant, including raw wastewater and activated sludge foam. The cell numbers estimated by competitive ELISA corresponded well with those obtained by plate counts. Hence, the antibody produced in this study was shown to be effective for the rapid monitoring of N. amarae in the activated sludge process.
- Published
- 2000
37. Role of the Costimulatory Molecule CD28 in the Development of Lupus in MRL/lprMice
- Author
-
Yoshifumi Tada, Kohei Nagasawa, Alexandra Ho, Fumitaka Morito, Syuichi Koarada, Osamu Ushiyama, Noriaki Suzuki, Akihide Ohta, and Tak W. Mak
- Subjects
Immunology ,Immunology and Allergy - Abstract
MRL/Mpj-lpr/lpr (MRL/lpr) mice develop autoimmune disorders, including lymphoproliferation, glomerulonephritis, autoantibody production, and hypergammaglobulinemia. To investigate the role of the costimulatory molecule CD28 in the development of these disorders, MRL/lpr mice lacking CD28 were generated by gene targeting. Compared with CD28+/+ MRL/lpr mice, CD28−/− MRL/lpr mice showed decreased lymphadenopathy but increased splenomegaly associated with the expansion of abnormal B220+ TCRαβ+ T cells. Although levels of IgM Abs were unchanged in CD28−/− MRL/lpr mice, the production of anti-DNA IgG Abs and IgG rheumatoid factors were suppressed. IgG deposition in the glomeruli was markedly decreased, and the development of glomerulonephritis was significantly retarded. Furthermore, renal vasculitis and arthritis were absent in CD28−/− MRL/lpr mice. These results indicate that, although CD28 is not required for the generation of the abnormal T cell population in MRL/lpr mice, it does play an important role in the development of autoimmune disease in these animals.
- Published
- 1999
38. An Analysis of Fever of Unknown Origin Defined by Newly Proposed Practical Criteria
- Author
-
Hiroshi Kohno, Akihide Ohta, Seiji Yamashiro, Tsuguya Fukui, Nobuhiro Ikeda, Masaya Yamaguchi, Kohhei Nagasawa, Noriaki Suzuki, Shunzo Koizumi, Osamu Ushiyama, and Yoshifumi Tada
- Subjects
Pediatrics ,medicine.medical_specialty ,Tuberculosis ,Diagnostic methods ,business.industry ,General Medicine ,Malignancy ,medicine.disease ,Polymyalgia rheumatica ,Collagen disorder ,medicine ,Fever of unknown origin ,Prospective cohort study ,business ,Illness behavior - Abstract
The criteria proposed by Petersdorf has been in use internationally to define the fever of unknown origin (FUO) since 1961 and the research of FUO has progressed with this criteria. Mean-while, new diagnostic methods have been developed and illness behavior of febrile patients has changed considerablly. Accordingly, the definition by Petersdorf is becoming less matched to current clinical situation. Therefore, we have developed a new practical criteria of FUO; i.e., out-patients who are febrile more than 2 weeks, documented temperature higher than 37.5 degrees C at least on one occasion and undetermined diagnosis and in-patients who are febrile more than 1 week with documented temperature higher than 37.5 degrees C, and undetermined diagnosis. Between October 1, 1993, and October 31, 1996, we prospectively collected a series of febrile patients who fulfilled our new criteria. We identified 56 patients by our criteria (23 male and 33 female, age: 49.7 +/- 20.6. range 15 to 88). Of this 56 patients, 19 (32%) were found to have infections, 18 (31%) had collagen disorders, 5 (9%) had malignancy and 6 (10%) had died. Of 56 patients, 38 (68%) were in the newly added group. Of these 38 patients, 4 patients had subacute necrotizing lymphoadenitis, 4 cytomegalovirus infection, 3 polymyalgia rheumatica, 3 tuberculosis. Four patients (10%) died. With our criteria, febrile patients who previously had not been included were found to have as poor a prognosis as with the Petersdorf group.
- Published
- 1999
39. Polyangiitis Overlap Syndrome with Eosinophilia Associated with an Elevated Serum Level of Major Basic Protein
- Author
-
Satomi Aihara, Syuichi Koarada, Osamu Ushiyama, Yoshifumi Tada, Kohei Nagasawa, Noriaki Suzuki, and Akihide Ohta
- Subjects
Pathology ,medicine.medical_specialty ,medicine.drug_class ,Pleural effusion ,Biopsy ,Polyangiitis overlap syndrome ,Elevated serum ,Leukocyte Count ,Ribonucleases ,Eosinophilia ,Internal Medicine ,medicine ,Humans ,Glucocorticoids ,Aged ,Skin ,biology ,medicine.diagnostic_test ,business.industry ,Angiography, Digital Subtraction ,Blood Proteins ,Syndrome ,General Medicine ,Eosinophil Granule Proteins ,respiratory system ,medicine.disease ,Thrombosis ,Polyarteritis Nodosa ,Eosinophils ,Thermography ,Skin biopsy ,Major basic protein ,biology.protein ,Corticosteroid ,Female ,Radiography, Thoracic ,medicine.symptom ,business - Abstract
Polyangiitis overlap syndrome is a new disease entity and the reported cases in the literature are still limited. We describe a female patient presenting with finger ulcers, skin eruptions, pleural effusion, interstitial pneumonia and eosinophilia. Skin biopsy showed systemic small-sized angiitis and thrombosis. She was diagnosed as having polyangiitis overlap syndrome and was successfully then treated with corticosteroid. It is also of interest that the disease activity was correlated with the number of eosinophils in peripheral blood. The measurement of the serum level of major basic protein released from eosinophils functioning as a coagulant indicated the possible association of eosinophilia with thrombosis and polyangiitis.
- Published
- 1999
40. Comparison of the refractive error with conventional refractometer and that with portable refractometer
- Author
-
Hidetoshi Hanazaki, Naomi Ishikawa, and Noriaki Suzuki
- Subjects
Refractive error ,Materials science ,Optics ,Refractometer ,business.industry ,medicine ,medicine.disease ,business ,Remote sensing - Published
- 1999
41. A Mean Value Property of Poly-Temperatures on a Strip Domain
- Author
-
Katsunori Shimomura, Noriaki Suzuki, and Masaharu Nishio
- Subjects
Property (philosophy) ,General Mathematics ,Mean value ,Mathematical analysis ,Geometry ,Domain (software engineering) ,Mathematics - Published
- 1998
42. A case-control study on risk factors for scleroderma
- Author
-
Osamu Ushiyama, Sumiko Kanegae, Seiji Yamashiro, Hiroshi Kohno, Akihide Ohta, Kohei Nagasawa, Mitsuru Mori, Noriaki Suzuki, Shunzo Koizumi, Yoshiyuki Ohno, and Kojiro Yoshihara
- Subjects
medicine.medical_specialty ,integumentary system ,business.industry ,Case-control study ,Medical school ,medicine.disease ,Rheumatology ,Scleroderma ,Internal medicine ,Orthopedic surgery ,Epidemiology ,Physical therapy ,medicine ,business - Abstract
We conducted a case-control study to evaluate the contribution of some risk factors to the development of scleroderma. Fifty-seven patients with scleroderma (seven males and 50 females) were interviewed with a structured questionnaire at Saga Medical School Hospital from 1993 to 1995. Fifty-seven controls, who were individually sex and age matched with each case, were also interviewed with the same questionnaire during the same period. Eight individuals of parents or siblings of the scleroderma patients had Raynaud’s phenomenon, as compared to none of the controls (P
- Published
- 1998
43. End-Stage Renal Failure due to Crescentic Glomerulonephritis in a Patient with Behçet’s Syndrome
- Author
-
Kohei Nagasawa, Noriaki Suzuki, Takanobu Sakemi, Yuji Ikeda, and Tomiyoshi Yoshiyuki
- Subjects
medicine.medical_specialty ,Systemic disease ,Crescentic glomerulonephritis ,business.industry ,Vascular disease ,Eye disease ,Glomerulonephritis ,urologic and male genital diseases ,medicine.disease ,Dermatology ,Surgery ,Nephrology ,medicine ,business ,Complication ,Uveitis ,Kidney disease - Abstract
We report a rare case of a patient with Behçet’s syndrome who developed end-stage renal failure due to crescentic glomerulonephritis (GN). A 20-year-old male patient had suffered from uveitis, aphthous mouth ulcers and genital ulceration for the past 7 years. His renal function rapidly deteriorated and renal biopsy specimens obtained when his serum creatinine level was 3 mg/dl showed diffuse proliferative GN with fibrous crescent formation in 75% of glomeruli excluding totally sclerotic glomeruli. Immune complexes were identified by demonstration of complement and immunoglobulins in the glomeruli. He developed end-stage renal failure during a 1-year course and received maintenance hemodialysis. We reviewed the literature on severe forms of GN in patients with Behçet’s syndrome.
- Published
- 1998
44. A local Hopf lemma for solutions of the one dimensional heat equation
- Author
-
Noriaki Suzuki
- Subjects
Laplace's equation ,Partial differential equation ,010308 nuclear & particles physics ,Differential equation ,General Mathematics ,010102 general mathematics ,Mathematical analysis ,Zero (complex analysis) ,Boundary (topology) ,01 natural sciences ,0103 physical sciences ,Order (group theory) ,Hopf lemma ,Heat equation ,0101 mathematics ,Mathematics - Abstract
The boundary behavior of solutions of the heat equation (temperature functions) is investigated. It is proved that a temperature function is identically equal to zero if it vanishes of finite order at some lateral boundary point where it attains a local minimum.
- Published
- 1997
45. A Case of Wegener's Granulomatosis Assoicated with Refractory Bowel Granulomatous U 1 cers
- Author
-
Takefumi Narikiyo, Akihide Ohta, Osamu Ushiyama, Noriaki Suzuki, Kohei Nagasawa, Yoshifumi Tada, and Yoshinori Nagai
- Subjects
Wegener s ,medicine.medical_specialty ,Refractory ,business.industry ,Immunology ,medicine ,Immunology and Allergy ,Digestive tract ,General Medicine ,Vasculitis ,medicine.disease ,business ,Dermatology - Abstract
経過中,大腸の肉芽腫性壊死性血管炎によると思われる横行結腸穿孔をきたし,その後も治療抵抗性に大腸潰瘍が遷延しているウエゲナー肉芽腫症(WG)の1例を経験した.症例は58歳女性.著明な咽頭潰瘍を主訴に1994年12月当院に入院し,抗生物質抵抗性の肺浸潤影,腎障害, C-ANCA陽性などからWGと診断した.ステロイドパルス後,横行結腸穿孔をきたし,緊急開腹にて腸管・腸間膜の血管炎様肉眼所見を認めた.人工肛門を造設し,局所安静とステロイド+シクロフォスファミドで加療し咽頭・肺・腎所見は軽快したが,壊死性肉芽腫性血管炎に伴う大腸潰瘍が術後10カ月以上遷延している.統計上,消化管病変は, WGの初発および経過中の症状としてはほとんどみられないが,死因の約12%を占めており,治療ならびに経過観察においては充分注意する必要があると考えられた.
- Published
- 1997
46. An interleave block delineation method in asynchronous transfer mode transport systems
- Author
-
Tokuhiro Kitami and Noriaki Suzuki
- Subjects
Interleaving ,Computer Networks and Communications ,business.industry ,Computer science ,Block (telecommunications) ,Asynchronous Transfer Mode ,Electronic engineering ,Electrical and Electronic Engineering ,business ,Computer hardware - Published
- 1997
47. Positive Toeplitz operators of finite rank on the parabolic Bergman spaces
- Author
-
Masaharu Nishio, Masahiro Yamada, and Noriaki Suzuki
- Subjects
Pure mathematics ,Mathematics::Functional Analysis ,Rank (linear algebra) ,Bergman space ,Mathematics::Operator Algebras ,Mathematics::Complex Variables ,General Mathematics ,Finite-rank operator ,Bilinear form ,Toeplitz matrix ,Mathematics ,Bergman kernel ,Toeplitz operator - Abstract
We define the Toeplitz operators on the parabolic Bergman spaces by using a positive bilinear form. In this setting we characterize finite rank Toeplitz operators. A relation with the Carleson inclusion is also discussed.
- Published
- 2013
48. Interpolation Polynomials of Entire Functions for Erdös-Type Weights
- Author
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Ryozi Sakai, Noriaki Suzuki, and Gou Nakamura
- Subjects
Discrete mathematics ,Article Subject ,General Mathematics ,Entire function ,Discrete orthogonal polynomials ,lcsh:Mathematics ,lcsh:QA1-939 ,Polynomial interpolation ,Classical orthogonal polynomials ,symbols.namesake ,Difference polynomials ,Orthogonal polynomials ,symbols ,Gaussian quadrature ,Trigonometric interpolation ,Mathematics - Abstract
Letℝ=(−∞,∞), and letQ∈C1(ℝ):ℝ→[0,∞)be an even function. In this paper, we consider some Lagrange interpolation polynomials and the Gauss-Jacobi quadrature formula of entire functions associated with Erdös-type weightsw(x)=e−Q(x),x∈ℝ, and we will estimate the error terms.
- Published
- 2013
49. A case of POEMS syndrome with various complications
- Author
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Kanako Tsuchiya, Akihide Ohta, Osamu Ushiyama, Noriaki Suzuki, Nobuhisa Yonemitsu, and Kohei Nagasawa
- Subjects
Male ,medicine.medical_specialty ,Hyperkalemia ,Immunology ,Myocardial Ischemia ,Paraproteinemias ,Brain tumor ,Disease ,Scleroderma ,Pathogenesis ,Glomerulonephritis ,medicine ,Humans ,Immunology and Allergy ,Aged ,POEMS syndrome ,Scleroderma, Systemic ,integumentary system ,Brain Neoplasms ,business.industry ,General Medicine ,medicine.disease ,Dermatology ,Colonic Neoplasms ,POEMS Syndrome ,medicine.symptom ,business ,Polyneuropathy - Abstract
A 65-year old man presented with complaints of sclerosis of skin and numbness in the extremities. During last 10 year, he had developed monoclonal gammopathy, Raynaud's phenomenon, ischemic heart disease, sigmoid colon cancer, hyperkalemia, polyneuropathy and scleroderma-like skin changes. Laboratory examinations revealed a monoclonal protein (IgA-lambda) and an elevated serum level of IL-6. Subsequently a diagnosis of POEMS syndrome was made based on the clinical features and laboratory findings which were characteristic of this syndrome. Further examinations showed the presence of glomerulonephritis and brain tumor. These various complications are of great interest in understanding the pathogenesis of POEMS syndrome.
- Published
- 1996
50. The effect of beraprost sodium on the Raynaud's phenomenon
- Author
-
Akihide Ohta, Osamu Ushiyama, Masaya Yamaguchi, Noriaki Suzuki, Megumi Hiida, and Kohei Nagasawa
- Subjects
Adult ,Male ,medicine.medical_specialty ,Vasodilator Agents ,Immunology ,Prostaglandin ,urologic and male genital diseases ,Tissue plasminogen activator ,Fingers ,chemistry.chemical_compound ,Mixed connective tissue disease ,Internal medicine ,von Willebrand Factor ,medicine ,Humans ,Immunology and Allergy ,Aged ,integumentary system ,business.industry ,Endothelins ,Raynaud Disease ,Beraprost sodium ,General Medicine ,Plasma levels ,Middle Aged ,medicine.disease ,Epoprostenol ,Beraprost ,Peripheral ,body regions ,chemistry ,Tissue Plasminogen Activator ,Cardiology ,Female ,Skin Temperature ,Endothelin receptor ,business ,Biomarkers ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
We investigated the effect of beraprost sodium (BPS) on the Raynaud's phenomenon on 15 patients with systemic sclerosis, 3 with mixed connective tissue disease and 1 with Raynaud's disease, respectively. After 12 weeks of administration of 60 micrograms/d BPS, the duration and the incidence of the Raynaud's symptom were significantly reduced and the dermal temperature on the fingers was found to be elevated. Of the parameters which are known to reflect vascular endothelial damages such as tissue plasminogen activator (t-PA), von Willebrand's factor (vWF) and endothelin, the plasma level of t-PA was significantly reduced by BPS. Furthermore, the capillary loop in the nail bed of the fingers seemed to increase in one patient by the treatment with BPS. These results suggest that BPS has a capacity to repair peripheral vascular damages resulting in the improvement of Raynaud's phenomenon.
- Published
- 1996
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