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A multistep synthesis was established for the preparation of a new vanillic acid-1, 2, 4-1triazole-3-thiol conjugate (4). Finally, several aromatized aldehydes reacted with compound (4) to produce Schiff bases derivatives (5–11). The purpose of this research is to prepare new vanillic acid derivatives with 1, 2, 4-triazole-3-thiol heterocyclic ring structures and to evaluate their antimicrobial activity in a preliminary assessment. Fourier-transform infrared (FT-IR) and proton nuclear magnetic resonance spectroscopy (1H-NMR) were used to verify the structures of the newly synthesized compounds. all the final synthesized compounds (5–11) were tested for antimicrobial activity. The findings of this study demonstrate the viability of synthesizing vanillic acid combined with a 1, 2, 4-triazole-3-thiol ring derivative, which then reacted with various aldehydes to yield several new Schiff bases derivatives. Finally, the presence of an electron-withdrawing group at the fourth position (p- chloro group) of the aromatic ring improves the antibacterial activity of the derivative of the vanillic acid-triazole conjugate. Compound 8 with para chloro substituted Schiff base derivative showed potent activity when compared to other final derivatives but of no activity toward K. pneumonia.

The current study aimed to assess the association of Single nucleotide Polymorphism, (rs11886868) in BcL11A gene with Fetal hemoglobin (HbF) level in β-thalassemia major patients in Babylon Province (Iraq), by enrolling individual of Arab ancestry. A total of 70 β-thalassemia major patients and 30 normal individual were enrolled Family history and HbF assay. All patients were transfusion depend with age mean (15.6 ± 1.20 years). On the other hand the selected control do not have history of family for thalassemia and doesn't have any disease with mean age (14.1 ± 0.7 years). For genotyping a ( PCR - RFLP) method was employed. Concerning BCL11A, rs11886868, there werenon significantly differences in allele frequencies andgenotypic between β- thalassemia major and control groups and was in agree with HARDY-WEINBERG equilibrium distribution. A significant (p <0.05) difference was observed in the mean level of Fetal hemoglobinamong the genotypes. Fetal hemoglobin percentage was found to be high in CC (74.70±5.55) genotype carriers individual followed by TT (65.14 ±9.38) and CT (56.53±5.91). [ABSTRACT FROM AUTHOR]