363 results on '"Nikola, T"'
Search Results
2. CCAT-prime Collaboration: Science Goals and Forecasts with Prime-Cam on the Fred Young Submillimeter Telescope
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collaboration, CCAT-Prime, Aravena, M., Austermann, J. E., Basu, K., Battaglia, N., Beringue, B., Bertoldi, F., Bigiel, F., Bond, J. R., Breysse, P. C., Broughton, C., Bustos, R., Chapman, S. C., Charmetant, M., Choi, S. K., Chung, D. T., Clark, S. E., Cothard, N. F., Crites, A. T., Dev, A., Douglas, K., Duell, C. J., Dunner, R., Ebina, H., Erler, J., Fich, M., Fissel, L. M., Foreman, S., Gallardo, P. A., Gao, J., García, Pablo, Giovanelli, R., Golec, J. E., Groppi, C. E., Haynes, M. P., Henke, D., Hensley, B., Herter, T., Higgins, R., Hlozek, R., Huber, A., Huber, Z., Hubmayr, J., Jackson, R., Johnstone, D., Karoumpis, C., Keating, L. C., Komatsu, E., Li, Y., Magnelli, B., Matthews, B. C., Mauskopf, P., McMahon, J. J., Meerburg, P. D., Meyers, J., Muralidhara, V., Murray, N. W., Niemack, M. D., Nikola, T., Okada, Y., Puddu, R., Riechers, D. A., Rosolowsky, E., Rossi, K., Rotermund, K., Roy, A., Sadavoy, S. I., Schaaf, R., Schilke, P., Scott, D., Simon, R., Sinclair, Adrian K., Sivakoff, G. R., Stacey, G. J., Stutz, Amelia M., Stutzki, J., Tahani, M., Thanjavur, K., Timmermann, R. A., Ullom, J. N., van Engelen, A., Vavagiakis, E. M., Vissers, M. R., Wheeler, J. D., White, S. D. M., Zhu, Y., and Zou, B.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present a detailed overview of the science goals and predictions for the Prime-Cam direct detection camera/spectrometer being constructed by the CCAT-prime collaboration for dedicated use on the Fred Young Submillimeter Telescope (FYST). The FYST is a wide-field, 6-m aperture submillimeter telescope being built (first light in mid-2024) by an international consortium of institutions led by Cornell University and sited at more than 5600 meters on Cerro Chajnantor in northern Chile. Prime-Cam is one of two instruments planned for FYST and will provide unprecedented spectroscopic and broadband measurement capabilities to address important astrophysical questions ranging from Big Bang cosmology through reionization and the formation of the first galaxies to star formation within our own Milky Way galaxy. Prime-Cam on the FYST will have a mapping speed that is over ten times greater than existing and near-term facilities for high-redshift science and broadband polarimetric imaging at frequencies above 300 GHz. We describe details of the science program enabled by this system and our preliminary survey strategies., Comment: 61 pages, 16 figures. Resubmitted to ApJSS July 11, 2022
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- 2021
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3. Learning attentional templates for value-based decision-making
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Jahn, Caroline I., Markov, Nikola T., Morea, Britney, Daw, Nathaniel D., Ebitz, R. Becket, and Buschman, Timothy J.
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- 2024
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4. CCAT-Prime: Characterization of the First 280 GHz MKID Array for Prime-Cam
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Choi, S. K., Duell, C. J., Austermann, J., Cothard, N. F., Gao, J., Freundt, R. G., Groppi, C., Herter, T., Hubmayr, J., Huber, Z. B., Keller, B., Li, Y., Mauskopf, P., Niemack, M. D., Nikola, T., Rossi, K., Sinclair, A., Stacey, G. J., Vavagiakis, E. M., Vissers, M., Tucker, C., Weeks, E., and Wheeler, J.
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- 2022
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5. CO and Fine-Structure Lines Reveal Low Metallicity in a Stellar-Mass-Rich Galaxy at z ~ 1?
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Lamarche, C., Stacey, G. J., Vishwas, A., Brisbin, D., Ferkinhoff, C., Nikola, T., Higdon, S. J. U., and Higdon, J.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present detections of the CO(4-3) and [C I] 609 $\mu$m spectral lines, as well as the dust continuum at 480.5 GHz (rest-frame), in 3C 368, a Fanaroff-Riley class II (FR-II) galaxy at redshift (z) 1.131. 3C 368 has a large stellar mass, ~ 3.6 x 10$^{11}$ M$_\odot$, and is undergoing an episode of vigorous star formation, at a rate of ~ 350 M$_\odot$/yr, and active galactic nucleus (AGN) activity, with radio-emitting lobes extended over ~ 73 kpc. Our observations allow us to inventory the molecular-gas reservoirs in 3C 368 by applying three independent methods: (1) using the CO(4-3)-line luminosity, excitation state of the gas, and an $\alpha_{CO}$ conversion factor, (2) scaling from the [C I]-line luminosity, and (3) adopting a gas-to-dust conversion factor. We also present gas-phase metallicity estimates in this source, both using far-infrared (FIR) fine-structure lines together with radio free-free continuum emission and independently employing the optical [O III] 5007 A and [O II] 3727 A lines (R$_{23}$ method). Both methods agree on a sub-solar gas-phase metallicity of ~ 0.3 Z$_\odot$. Intriguingly, comparing the molecular-gas mass estimated using this sub-solar metallicity, M$_{gas}$ ~ 6.4 x 10$^{10}$ M$_\odot$, to dust-mass estimates from multi-component spectral energy distribution (SED) modeling, M$_{dust}$ ~ 1.4 x 10$^8$ M$_\odot$, yields a gas-to-dust ratio within ~ 15% of the accepted value for a metallicity of 0.3 Z$_\odot$. The derived gas-mass puts 3C 368 on par with other galaxies at z ~ 1 in terms of specific star-formation rate and gas fraction. However, it does not explain how a galaxy can amass such a large stellar population while maintaining such a low gas-phase metallicity. Perhaps 3C 368 has recently undergone a merger, accreting pristine molecular gas from an external source., Comment: 10 pages, 5 figures, 2 tables, accepted for publication in the Astrophysical Journal
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- 2019
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6. [CII] luminosity models and large-scale image cubes based on COSMOS 2020 and ALPINE-ALMA [CII] data back to the epoch of reionisation
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Clarke, J., primary, Karoumpis, C., additional, Riechers, D., additional, Magnelli, B., additional, Okada, Y., additional, Dev, A., additional, Nikola, T., additional, and Bertoldi, F., additional
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- 2024
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7. Resolving Star Formation on Sub-Kiloparsec Scales in the High-Redshift Galaxy SDP.11 Using Gravitational Lensing
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Lamarche, C., Verma, A., Vishwas, A., Stacey, G. J., Brisbin, D., Ferkinhoff, C., Nikola, T., Higdon, S. J. U., Higdon, J., and Tecza, M.
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Astrophysics - Astrophysics of Galaxies - Abstract
We investigate the properties of the interstellar medium, star formation, and the current-day stellar population in the strongly-lensed star-forming galaxy H-ATLAS J091043.1-000321 (SDP.11), at z = 1.7830, using new Herschel and ALMA observations of far-infrared fine-structure lines of carbon, oxygen and nitrogen. We report detections of the [O III] 52 um, [N III] 57 um, and [O I] 63 um lines from Herschel/PACS, and present high-resolution imaging of the [C II] 158 um line, and underlying continuum, using ALMA. We resolve the [C II] line emission into two spatially-offset Einstein rings, tracing the red- and blue-velocity components of the line, in the ALMA/Band-9 observations at 0.2" resolution. The values seen in the [C II]/FIR ratio map, as low as ~ 0.02% at the peak of the dust continuum, are similar to those of local ULIRGs, suggesting an intense starburst in this source. This is consistent with the high intrinsic FIR luminosity (~ 3 x 10^12 Lo), ~ 16 Myr gas depletion timescale, and < 8 Myr timescale since the last starburst episode, estimated from the hardness of the UV radiation field. By applying gravitational lensing models to the visibilities in the uv-plane, we find that the lensing magnification factor varies by a factor of two across SDP.11, affecting the observed line profiles. After correcting for the effects of differential lensing, a symmetric line profile is recovered, suggesting that the starburst present here may not be the result of a major merger, as is the case for local ULIRGs, but instead could be powered by star-formation activity spread across a 3-5 kpc rotating disk., Comment: 17 pages, 8 figures, 3 tables, accepted for publication in the Astrophysical Journal
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- 2018
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8. CCAT-prime: Science with an Ultra-widefield Submillimeter Observatory at Cerro Chajnantor
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Stacey, G. J., Aravena, M., Basu, K., Battaglia, N., Beringue, B., Bertoldi, F., Bond, J. R., Breysse, P., Bustos, R., Chapman, S., Chung, D. T., Cothard, N., Erler, J., Fich, M., Foreman, S., Gallardo, P., Giovanelli, R., Graf, U. U., Haynes, M. P., Herrera-Camus, R., Herter, T. L., Hložek, R., Johnstone, D., Keating, L., Magnelli, B., Meerburg, D., Meyers, J., Murray, N., Niemack, M., Nikola, T., Nolta, M., Parshley, S. C., Riechers, D., Schilke, P., Scott, D., Stein, G., Stevens, J., Stutzki, J., Vavagiakis, E. M., and Viero, M. P.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the detailed science case, and brief descriptions of the telescope design, site, and first light instrument plans for a new ultra-wide field submillimeter observatory, CCAT-prime, that we are constructing at a 5600 m elevation site on Cerro Chajnantor in northern Chile. Our science goals are to study star and galaxy formation from the epoch of reionization to the present, investigate the growth of structure in the Universe, improve the precision of B-mode CMB measurements, and investigate the interstellar medium and star formation in the Galaxy and nearby galaxies through spectroscopic, polarimetric, and broadband surveys at wavelengths from 200 um to 2 mm. These goals are realized with our two first light instruments, a large field-of-view (FoV) bolometer-based imager called Prime-Cam (that has both camera and an imaging spectrometer modules), and a multi-beam submillimeter heterodyne spectrometer, CHAI. CCAT-prime will have very high surface accuracy and very low system emissivity, so that combined with its wide FoV at the unsurpassed CCAT site our telescope/instrumentation combination is ideally suited to pursue this science. The CCAT-prime telescope is being designed and built by Vertex Antennentechnik GmbH. We expect to achieve first light in the spring of 2021., Comment: Presented at SPIE Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy IX, June 14th, 2018
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- 2018
9. CO-Dark Star Formation and Black Hole Activity in 3C 368 at z = 1.131: Coeval Growth of Stellar and Supermassive Black Hole Masses
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Lamarche, C., Stacey, G., Brisbin, D., Ferkinhoff, C., Hailey-Dunsheath, S., Nikola, T., Riechers, D., Sharon, C. E., Spoon, H., and Vishwas, A.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the detection of four far-infrared fine-structure oxygen lines, as well as strong upper limits for the CO(2-1) and [N II] 205 um lines, in 3C 368, a well-studied radio-loud galaxy at z = 1.131. These new oxygen lines, taken in conjunction with previously observed neon and carbon fine-structure lines, suggest a powerful active galactic nucleus (AGN), accompanied by vigorous and extended star formation. A starburst dominated by O8 stars, with an age of ~6.5 Myr, provides a good fit to the fine-structure line data. This estimated age of the starburst makes it nearly concurrent with the latest episode of AGN activity, suggesting a link between the growth of the supermassive black hole and stellar population in this source. We do not detect the CO(2-1) line, down to a level twelve times lower than the expected value for star forming galaxies. This lack of CO line emission is consistent with recent star formation activity if the star-forming molecular gas has low metallicity, is highly fractionated (such that CO is photodissociated through much of the clouds), or is chemically very young (such that CO has not yet had time to form). It is also possible, though we argue unlikely, that the ensemble of fine structure lines are emitted from the region heated by the AGN., Comment: 10 pages, 4 figures, 2 tables, accepted for publication in the Astrophysical Journal
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- 2017
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10. Velocity resolved [CII] spectroscopy of the center and the BCLMP302 region of M33 (HerM33es)
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Mookerjea, B., Israel, F., Kramer, C., Nikola, T., Braine, J., Ossenkopf, V., Roellig, M., Henkel, C., van der Werf, P., van der Tak, F., and Wiedner, M. C.
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Astrophysics - Astrophysics of Galaxies - Abstract
We aim to understand the contribution of the ionized, atomic and molecular phases of the ISM to the [CII] emission from clouds near the dynamical center and the BCLMP302 HII region in the north of the nearby galaxy M33 at a spatial resolution of 50pc. We combine high resolution [CII] spectra taken with the HIFI spectrometer onboard the Herschel satellite with [CII] Herschel-PACS maps and ground-based observations of CO(2-1) and HI. All data are at a common spatial resolution of 50pc. Typically, the [CII] lines have widths intermediate between the narrower CO(2-1) and broader HI line profiles. We decomposed the [CII] spectra in terms of contribution from molecular and atomic gas detected in CO(2-1) and HI, respectively. We find that the relative contribution of molecular and atomic gas traced by CO(2-1) and HI varies depends mostly on the local physical conditions and geometry. We estimate that 11-60% and 5-34% of the [CII] intensities in the center and in BCLMP302, respectively, arise at velocities showing no CO(2-1) or HI emission and could arise in CO-dark molecular gas. The deduced strong variation in the [CII] emission not associated with CO and HI cannot be explained in terms of differences in A_v, far-ultraviolet radiation field, and metallicity between the two studied regions. Hence the relative amounts of diffuse (CO-dark) and dense molecular gas possibly vary on spatial scales smaller than 50pc. Based on the emission measure observed at radio wavelengths we estimate the contribution of ionized gas at a few positions to lie between 10-25%. The correlations between the intensities of tracers corresponding to the same velocity range as [CII], differ from the correlation derived from PACS data. The results in this paper emphasize the need for velocity-resolved observations to discern the contribution of different components of the ISM to [CII] emission. (abridged), Comment: Accepted for publication in A&A
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- 2015
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11. Analysis of optimization possibilities of slat conveyor drives
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Živanić Dragan Đ. and Ilanković Nikola T.
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slat conveyor ,drive optimization ,drive chain ,drive unit ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The paper presents an analysis of the possibility of optimizing the drive of slat conveyors, which primarily refers to the choice of the drive chain and the number of drive units. The basic characteristics of slat conveyors, as a mean of continuous transport, procedures for calculating the basic parameters and the choice of basic elements of the conveyor are presented. Cases with one angular and combinations with several line drive units are considered. In order to observe influential parameters, variants with different route lengths and line weight of transported material were considered. At the end of the paper, the obtained results were analyzed and appropriate conclusions were made.
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- 2021
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12. Building compositional tasks with shared neural subspaces
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Tafazoli, Sina, primary, Bouchacourt, Flora, additional, Ardalan, Adel, additional, Markov, Nikola T, additional, Uchimura, Motoaki, additional, Gomes Mattar, Marcelo Gomes, additional, Daw, Nathaniel Douglass, additional, and Buschman, Timothy J, additional
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- 2024
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13. High-J CO SLEDs in nearby infrared bright galaxies observed by Herschel-PACS
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Mashian, N., Sturm, E., Sternberg, A., Janssen, A., Hailey-Dunsheath, S., Fischer, J., Contursi, A., Gonzalez-Alfonso, E., Gracia-Carpio, J., Poglitsch, A., Veilleux, S., Davies, R., Genzel, R., Lutz, D., Tacconi, L., Verma, A., Weiß, A., Polisensky, E., and Nikola, T.
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Astrophysics - Astrophysics of Galaxies - Abstract
We report the detection of far-infrared (FIR) CO rotational emission from nearby active galactic nuclei (AGN) and starburst galaxies, as well as several merging systems and Ultra-Luminous Infrared Galaxies (ULIRGs). Using Herschel-PACS, we have detected transitions in the J$_{upp}$ = 14 - 20 range ($\lambda \sim$ 130 - 185 $\mu$m, $\nu \sim$ 1612 - 2300 GHz) with upper limits on (and in two cases, detections of) CO line fluxes up to J$_{upp}$ = 30. The PACS CO data obtained here provide the first well-sampled FIR extragalactic CO SLEDs for this range, and will be an essential reference for future high redshift studies. We find a large range in the overall SLED shape, even amongst galaxies of similar type, demonstrating the uncertainties in relying solely on high-J CO diagnostics to characterize the excitation source of a galaxy. Combining our data with low-J line intensities taken from the literature, we present a CO ratio-ratio diagram and discuss its potential diagnostic value in distinguishing excitation sources and physical properties of the molecular gas. The position of a galaxy on such a diagram is less a signature of its excitation mechanism, than an indicator of the presence (or absence) of warm, dense molecular gas. We then quantitatively analyze the CO emission from a subset of the detected sources with Large Velocity Gradient (LVG) radiative transfer models to fit the CO SLEDs. Using both single-component and two-component LVG models to fit the kinetic temperature, velocity gradient, number density and column density of the gas, we derive the molecular gas mass and the corresponding CO-to-H$_2$ conversion factor, $\alpha_{CO}$, for each respective source. For the ULIRGs we find $\alpha$ values in the canonical range 0.4 - 5 M$_\odot$/(K kms$^{-1}$pc$^2$), while for the other objects, $\alpha$ varies between 0.2 and 14.} Finally, we compare our best-fit LVG model .., Comment: 39 pages, 3 figures; Accepted to ApJ
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- 2014
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14. Cultural antinomies of the contemporary Serbian society: Premodern mentality vs. Postmodern identity
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Božilović Nikola T.
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culture ,identity ,postmodernism ,premodern state of society ,serbia ,Education ,Literature (General) ,PN1-6790 - Abstract
Globalization has permeated all aspects of social life (economic, political, cultural) and affected the daily life of people. Postindustrial society and postmodern culture have made a significant impact on the transformation of identities, which have truly become liquid - multidimensional, discontinuous, decentralized, fragmented, unstable and inconstant. Parallel with this, new tendencies in culture have almost completely narrowed the boundary between high and popular creativity, thus challenging the status of the established, until then recognized values. These changes have also become evident in the contemporary Serbian society, which is obsessed by preserving the tradition and long-developed identities. By chance, that society has had one foot in the postmodern information world, with the other stuck in the quagmire of old habits and misconceptions inherited from the period of premodern social awareness. By analysing crucial value aspects (traditionalism, conformism, authoritarianism and nationalism), the author of this paper attempts to provide an explanation (which is the basic precondition for the resolution) of the ambivalent and, seemingly, inescapable situation in which the culture of Serbian society finds itself.
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- 2020
15. Novel Tetrahydroisoquinoline-Based Heterocyclic Compounds Efficiently Inhibit SARS-CoV-2 Infection In Vitro
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Xi Wang, Nikola T. Burdzhiev, Hengrui Hu, Yufeng Li, Jiang Li, Vesela V. Lozanova, Meglena I. Kandinska, and Manli Wang
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SARS-CoV-2 ,antivirals ,1,2,3,4-tetrahydroisoquinoline ,indole ,chloroquine ,Microbiology ,QR1-502 - Abstract
The ongoing COVID-19 pandemic has caused over six million deaths and huge economic burdens worldwide. Antivirals against its causative agent, SARS-CoV-2, are in urgent demand. Previously, we reported that heterocylic compounds, i.e., chloroquine (CQ) and hydroxychloroquine (HCQ), are potent in inhibiting SARS-CoV-2 replication in vitro. In this study, we discussed the syntheses of two novel heterocylic compounds: tert-butyl rel-4-(((3R,4S)-3-(1H-indol-3-yl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinolin-4-yl)methyl)piperazine-1-carboxylate (trans-1) and rel-(3R,4S)-3-(1H-indol-3-yl)-4-(piperazin-1-ylmethyl)-2-propyl-3,4-dihydroisoquinolin-1(2H)-one (trans-2), which effectively suppressed authentic SARS-CoV-2 replication in Vero E6 cells. Compound trans-1 showed higher anti-SARS-CoV-2 activity than trans-2, with a half maximal effective concentration (EC50) of 3.15 μM and a selective index (SI) exceeding 63.49, which demonstrated comparable potency to CQ or HCQ. Additional anti-SARS-CoV-2 tests on Calu-3 human lung cells showed that trans-1 efficiently inhibited viral replication (EC50 = 2.78 μM; SI: > 71.94) and performed better than CQ (EC50 = 44.90 μM; SI = 2.94). The time of an addition assay showed that the action mechanism of trans-1 differed from that of CQ, as it mainly inhibited the post-entry viral replication in both Vero E6 and Calu-3 cells. In addition, the differences between the antiviral mechanisms of these novel compounds and CQ were discussed.
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- 2023
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16. Synthesis of Novel 1-Oxo-2,3,4-trisubstituted Tetrahydroisoquinoline Derivatives, Bearing Other Heterocyclic Moieties and Comparative Preliminary Study of Anti-Coronavirus Activity of Selected Compounds
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Meglena I. Kandinska, Nikola T. Burdzhiev, Diana V. Cheshmedzhieva, Sonia V. Ilieva, Peter P. Grozdanov, Neli Vilhelmova-Ilieva, Nadya Nikolova, Vesela V. Lozanova, and Ivanka Nikolova
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tetrahydroisoquinolines ,homophthalic anhydride ,imines ,anti-coronavirus activity ,HCoV-OC43 ,HCoV-229E ,Organic chemistry ,QD241-441 - Abstract
A series of novel 1-oxo-2,3,4-trisubstituted tetrahydroisoquinoline (THIQ) derivatives bearing other heterocyclic moieties in their structure were synthesized based on the reaction between homophthalic anhydride and imines. Initial studies were carried out to establish the anti-coronavirus activity of some of the newly obtained THIQ-derivatives against two strains of human coronavirus-229E and OC-43. Their antiviral activity was compared with that of their close analogues, piperidinones and thiomorpholinones, previously synthesized in our group, with aim to expand the range of the tested representative sample and to obtain valuable preliminary information about biological properties of a wider variety of compounds.
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- 2023
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17. The Design of the CCAT-prime Epoch of Reionization Spectrometer Instrument
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Cothard, N. F., Choi, S. K., Duell, C. J., Herter, T., Hubmayr, J., McMahon, J., Niemack, M. D., Nikola, T., Sierra, C., Stacey, G. J., Vavagiakis, E. M., Wollack, E. J., and Zou, B.
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- 2020
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18. Sensitivity of the Prime-Cam Instrument on the CCAT-Prime Telescope
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Choi, S. K., Austermann, J., Basu, K., Battaglia, N., Bertoldi, F., Chung, D. T., Cothard, N. F., Duff, S., Duell, C. J., Gallardo, P. A., Gao, J., Herter, T., Hubmayr, J., Niemack, M. D., Nikola, T., Riechers, D., Rossi, K., Stacey, G. J., Stevens, J. R., Vavagiakis, E. M., Vissers, M., and Walker, S.
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- 2020
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19. Gas and dust cooling along the major axis of M33 (HerM33es): ISO/LWS CII observations
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Kramer, C., Abreu-Vicente, J., Garcia-Burillo, S., Relano, M., Aalto, S., Boquien, M., Braine, J., Buchbender, C., Gratier, P., Israel, F. P., Nikola, T., Roellig, M., Verley, S., van der Werf, P., and Xilouris, E. M.
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Astrophysics - Astrophysics of Galaxies - Abstract
We aim to better understand the heating of the gas by observing the prominent gas cooling line [CII] at 158um in the low-metallicity environment of the Local Group spiral galaxy M33 at scales of 280pc. In particular, we aim at describing the variation of the photoelectric heating efficiency with galactic environment. In this unbiased study, we used ISO/LWS [CII] observations along the major axis of M33, in combination with Herschel PACS and SPIRE continuum maps, IRAM 30m CO 2-1 and VLA HI data to study the variation of velocity integrated intensities. The ratio of [CII] emission over the far-infrared continuum is used as a proxy for the heating efficiency, and models of photon-dominated regions are used to study the local physical densities, FUV radiation fields, and average column densities of the molecular clouds. The heating efficiency stays constant at 0.8% in the inner 4.5kpc radius of the galaxy where it starts to increase to reach values of ~3% in the outskirts at about 6kpc radial distance. The rise of efficiency is explained in the framework of PDR models by lowered volume densities and FUV fields, for optical extinctions of only a few magnitudes at constant metallicity. In view of the significant fraction of HI emission stemming from PDRs, and for typical pressures found in the Galactic cold neutral medium (CNM) traced by HI emission, the CNM contributes ~15% to the observed [CII] emission in the inner 2kpc radius of M33. The CNM contribution remains largely undetermined in the south, while positions between 2 and 7.3kpc radial distance in the north of M33 show a contribution of ~40%+-20%., Comment: (16 pages, a version with higher resolution figures may be downloaded from http://www.iram.es/IRAMES/hermesWiki/HermesPublications)
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- 2013
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20. Beyond Traditional Use of Alchemilla vulgaris: Genoprotective and Antitumor Activity In Vitro
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Sanja Jelača, Zora Dajić-Stevanović, Nenad Vuković, Stefan Kolašinac, Antoaneta Trendafilova, Paraskev Nedialkov, Miroslava Stanković, Nasta Tanić, Nikola T. Tanić, Aleksandar Acović, Sanja Mijatović, and Danijela Maksimović-Ivanić
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Alchemilla vulgaris L. ,antitumor action ,antioxidative activity ,genoprotective effect ,Organic chemistry ,QD241-441 - Abstract
Alchemilla vulgaris L. (lady’s mantle) was used for centuries in Europe and Balkan countries for treatments of numerous conditions and diseases of the reproductive system, yet some of the biological activities of lady’s mantle have been poorly studied and neglected. The present study aimed to estimate the potential of A. vulgaris ethanolic extract from Southeast Serbia to prevent and suppress tumor development in vitro, validated by antioxidant, genoprotective, and cytotoxic properties. A total of 45 compounds were detected by UHPLC–HRMS analysis in A. vulgaris ethanolic extract. Measurement of antioxidant activity revealed the significant potential of the tested extract to scavenge free radicals. In addition, the analysis of micronuclei showed an in vitro protective effect on chromosome aberrations in peripheral human lymphocytes. A. vulgaris extract strongly suppressed the growth of human cell lines derived from different types of tumors (MCF-7, A375, A549, and HCT116). The observed antitumor effect is realized through the blockade of cell division, caspase-dependent apoptosis, and autophagic cell death. Our study has shown that Alchemilla vulgaris L. is a valuable source of bioactive compounds able to protect the subcellular structure from damage, thus preventing tumorigenesis as well as suppressing tumor cell growth.
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- 2022
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21. Mid-IR FORCAST/SOFIA Observations of M82
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Nikola, T., Herter, T. L., Vacca, W. D., Adams, J. D., De Buizer, J. M., Gull, G. E., Henderson, C. P., Keller, L. D., Morris, M. R., Schoenwald, J., Stacey, G., and Tielens, A.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present 75"x75" size maps of M82 at 6.4 micron, 6.6 micron, 7.7 micron, 31.5 micron, and 37.1 micron with a resolution of ~4" that we have obtained with the mid-IR camera FORCAST on SOFIA. We find strong emission from the inner 60" (~1kpc) along the major axis, with the main peak 5" west-southwest of the nucleus and a secondary peak 4" east-northeast of the nucleus. The detailed morphology of the emission differs among the bands, which is likely due to different dust components dominating the continuum emission at short mid-IR wavelengths and long mid-IR wavelengths. We include Spitzer-IRS and Herschel/PACS 70 micron data to fit spectral energy distribution templates at both emission peaks. The best fitting templates have extinctions of A_V = 18 and A_V = 9 toward the main and secondary emission peak and we estimated a color temperature of 68 K at both peaks from the 31 micron and 37 micron measurement. At the emission peaks the estimated dust masses are on the order of 10^{4} M_sun., Comment: ApJL in press (ApJ, 749, L19), article also available at at http://stacks.iop.org/2041-8205/749/L19
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- 2012
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22. First Science Observations with SOFIA/FORCAST: The FORCAST Mid-infrared Camera
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Herter, T. L., Adams, J. D., De Buizer, J. M., Gull, G. E., Schoenwald, J., Henderson, C. P., Keller, L. D., Nikola, T., Stacey, G., and Vacca, W. D.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Stratospheric Observatory for Infrared Astronomy (SOFIA) completed its first light flight in May of 2010 using the facility mid-infrared instrument FORCAST. Since then, FORCAST has successfully completed thirteen science flights on SOFIA. In this paper we describe the design, operation and performance of FORCAST as it relates to the initial three Short Science flights. FORCAST was able to achieve near diffraction-limited images for lambda > 30 microns allowing unique science results from the start with SOFIA. We also describe ongoing and future modifications that will improve overall capabilities and performance of FORCAST., Comment: 13 pages, 3 figures, Accepted by ApJ Letters
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- 2012
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23. Mid-J CO Emission From NGC 891: Microturbulent Molecular Shocks in Normal Star Forming Galaxies
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Nikola, T., Stacey, G. J., Brisbin, D., Ferkinhoff, C., Hailey-Dunsheath, S., Parshley, S., and Tucker, C.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We have detected the CO(6-5), CO(7-6), and [CI] 370 micron lines from the nuclear region of NGC 891 with our submillimeter grating spectrometer ZEUS on the CSO. These lines provide constraints on photodissociation region (PDR) and shock models that have been invoked to explain the H_2 S(0), S(1), and S(2) lines observed with Spitzer. We analyze our data together with the H_2 lines, CO(3-2), and IR continuum from the literature using a combined PDR/shock model. We find that the mid-J CO originates almost entirely from shock-excited warm molecular gas; contributions from PDRs are negligible. Also, almost all the H_2 S(2) and half of the S(1) line is predicted to emerge from shocks. Shocks with a pre-shock density of 2x10^4 cm^-3 and velocities of 10 km/s and 20 km/s for C-shocks and J-shocks, respectively, provide the best fit. In contrast, the [CI] line emission arises exclusively from the PDR component, which is best parameterized by a density of 3.2x10^3 cm^-3 and a FUV field of G_o = 100 for both PDR/shock-type combinations. Our mid-J CO observations show that turbulence is a very important heating source in molecular clouds, even in normal quiescent galaxies. The most likely energy sources for the shocks are supernovae or outflows from YSOs. The energetics of these shock sources favor C-shock excitation of the lines., Comment: 18 pages, 2 figures, 6 tables, accepted by ApJ
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- 2011
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24. The Herschel M33 extended survey (HerM33es): PACS spectroscopy of the star forming region BCLMP 302
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Mookerjea, B., Kramer, C., Buchbender, C., Boquien, M., Verley, S., Relano, M., Quintana-Lacaci, G., Aalto, S., Braine, J., Calzetti, D., Combes, F., Garcia-Burillo, S., Gratier, P., Henkel, C., Israel, F., Lord, S., Nikola, T., Roellig, M., Stacey, G., Tabatabaei, F. S., van der Tak, F., and van der Werf, P.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Context: The emission line of [CII] at 158 micron is one of the strongest cooling lines of the interstellar medium (ISM) in galaxies. Aims: Disentangling the relative contributions of the different ISM phases to [CII] emission, is a major topic of the HerM33es program, a Herschel key project to study the ISM in the nearby spiral galaxy M33. Methods: Using PACS, we have mapped the emission of [CII] 158 micron, [OI] 63 micron, and other FIR lines in a 2'x2' region of the northern spiral arm of M33, centered on the HII region BCLMP302. At the peak of H-alpha emission, we have observed in addition a velocity resolved [CII] spectrum using HIFI. We use scatterplots to compare these data with PACS 160 micron continuum maps, and with maps of CO and HI data, at a common resolution of 12 arcsec or 50 pc. Maps of H-alpha and 24 micron emission observed with Spitzer are used to estimate the SFR. We have created maps of the [CII] and [OI] 63 micron emission and detected [NII] 122 micron and NIII 57 micron at individual positions. Results: The [CII] line observed with HIFI is significantly broader than that of CO, and slightly blue-shifted. In addition, there is little spatial correlation between [CII] observed with PACS and CO over the mapped region. There is even less spatial correlation between [CII] and the atomic gas traced by HI. Detailed comparison of the observed intensities towards the HII region with models of photo ionization and photon dominated regions, confirms that a significant fraction, 20--30%, of the observed [CII] emission stems from the ionized gas and not from the molecular cloud. The gas heating efficiency, using the ratio between [CII] and the TIR as a proxy, varies between 0.07 and 1.5%, with the largest variations found outside the HII region., Comment: Accepted for publication in A&A. 12 pages, 12 figures
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- 2011
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25. A 158 Micron [CII] Line Survey of Galaxies at z ~ 1 to 2: An Indicator of Star Formation in the Early Universe
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Stacey, G. J., Hailey-Dunsheath, S., Ferkinhoff, C., Nikola, T., Parshley, S. C., Benford, D. J., Staguhn, J. G., and Fiolet, N.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We have detected the 158 {\mu}m [CII] line from 12 galaxies at z~1-2. This is the first survey of this important starformation tracer at redshifts covering the epoch of maximum star-formation in the Universe and quadruples the number of reported high z [CII] detections. The line is very luminous, between <0.024-0.65% of the far-infrared continuum luminosity of our sources, and arises from PDRs on molecular cloud surfaces. An exception is PKS 0215+015, where half of the [CII] emission could arise from XDRs near the central AGN. The L[CII] /LFIR ratio in our star-formation-dominated systems is ~8 times larger than that of our AGN-dominated systems. Therefore this ratio selects for star-formation-dominated systems. Furthermore, the L[CII]/LFIR and L[CII]/L(CO(1-0)) ratios in our starforming galaxies and nearby starburst galaxies are the same, so that luminous starforming galaxies at earlier epochs (z~1-2) appear to be scaled up versions of local starbursts entailing kilo-parsec-scale starbursts. Most of the FIR and [CII] radiation from our AGN-dominated sample (excepting PKS 0215+015) also arises from kpc scale starformation, but with far-UV radiation fields ~8 times more intense than in our star-formation-dominated sample. We speculate that the onset of AGN activity stimulates large-scale star-formation activity within AGN-dominated systems. This idea is supported by the relatively strong [OIII] line emission, indicating very young stars, that was recently observed in high z composite AGN/starburst systems. Our results confirm the utility of the [CII] line, and in particular, the L[CII]/L(FIR) and L[CII]/LCO(1-0) ratios as a tracers of star-formation in galaxies at high redshifts., Comment: 33 pages, 5 figures
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- 2010
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26. The Energetics of Molecular Gas in NGC 891 from H2 and FIR Spectroscopy
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Stacey, G. J., Charmandaris, V., Boulanger, F., Wu, Yanling, Combes, F., Higdon, S. J. U., Smith, J. D. T., and Nikola, T.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We have studied the molecular hydrogen energetics of the edge-on spiral galaxy NGC\,891, using a 34-position map in the lowest three pure rotational H$_2$ lines observed with the Spitzer Infrared Spectrograph. The S(0), S(1), and S(2) lines are bright with an extinction corrected total luminosity of $\sim2.8 \times 10^{7}$ L$_{\odot}$, or 0.09\% of the total-infrared luminosity of NGC\,891. The H$_2$ line ratios are nearly constant along the plane of the galaxy -- we do not observe the previously reported strong drop-off in the S(1)/S(0) line intensity ratio in the outer regions of the galaxy, so we find no evidence for the very massive cold CO-free molecular clouds invoked to explain the past observations. The H$_2$ level excitation temperatures increase monotonically indicating more than one component to the emitting gas. More than 99\% of the mass is in the lowest excitation (T$_{ex}$ $\sim$125 K) ``warm'' component. In the inner galaxy, the warm H$_2$ emitting gas is $\sim$15\% of the CO(1-0)-traced cool molecular gas, while in the outer regions the fraction is twice as high. This large mass of warm gas is heated by a combination of the far-UV photons from stars in photo-dissociation regions (PDRs) and the dissipation of turbulent kinetic energy. Including the observed far-infrared [OI] and [CII] fine-structure line emission and far-infrared continuum emission in a self-consistent manner to constrain the PDR models, we find essentially all of the S(0) and most (70\%) of the S(1) line arises from low excitation PDRs, while most (80\%) of the S(2) and the remainder of the S(1) line emission arises from low velocity microturbulent dissipation., Comment: Accepted for publication in The Astrophysical Journal. Figure 10 available at http://www.physics.uoc.gr/~vassilis/papers/ngc891.pdf
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- 2010
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27. First Detection of the [OIII] 88 micron Line at High Redshifts: Characterizing the Starburst and Narrow Line Regions in Extreme Luminosity Systems
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Ferkinhoff, C., Hailey-Dunsheath, S., Nikola, T., Parshley, S. C., Stacey, G. J., Benford, D. J., and Staguhn, J. G.
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Astrophysics - Cosmology and Extragalactic Astrophysics ,Astrophysics - Galaxy Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We have made the first detections of the 88 micron [OIII] line from galaxies in the early Universe, detecting the line from the lensed AGN/starburst composite systems APM 08279+5255 at z = 3.911 and SMM J02399-0136 at z = 2.8076. The line is exceptionally bright from both systems, with apparent (lensed) luminosities ~10^11 L_solar. For APM 08279, the [OIII] line flux can be modeled in a star formation paradigm, with the stellar radiation field dominated by stars with effective temperatures, Teff >36,000 K, similar to the starburst found in M82. The model implies ~35% of the total far-IR luminosity of the system is generated by the starburst, with the remainder arising from dust heated by the AGN. The 88 micron line can also be generated in the narrow line region of the AGN if gas densities are around a few 1000 cm-3. For SMM J02399 the [OIII] line likely arises from HII regions formed by hot (Teff >40,000 K) young stars in a massive starburst that dominates the far-IR luminosity of the system. The present work demonstrates the utility of the [OIII] line for characterizing starbursts and AGN within galaxies in the early Universe. These are the first detections of this astrophysically important line from galaxies beyond a redshift of 0.05., Comment: Accepted for publication in ApJ Letters, 17 pages, 2 figures
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- 2010
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28. Detection of the 158 micron [CII] Transition at z=1.3: Evidence for a Galaxy-Wide Starburst
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Hailey-Dunsheath, S., Nikola, T., Stacey, G. J., Oberst, T. E., Parshley, S. C., Benford, D. J., Staguhn, J. G., and Tucker, C. E.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We report the detection of 158 micron [CII] fine-structure line emission from MIPS J142824.0+352619, a hyperluminous (L_IR ~ 10^13 L_sun) starburst galaxy at z=1.3. The line is bright, and corresponds to a fraction L_[CII]/L_FIR = 2 x 10^-3 of the far-IR (FIR) continuum. The [CII], CO, and FIR continuum emission may be modeled as arising from photodissociation regions (PDRs) that have a characteristic gas density of n ~ 10^4.2 cm^-3, and that are illuminated by a far-UV radiation field ~10^3.2 times more intense than the local interstellar radiation field. The mass in these PDRs accounts for approximately half of the molecular gas mass in this galaxy. The L_[CII]/L_FIR ratio is higher than observed in local ULIRGs or in the few high-redshift QSOs detected in [CII], but the L_[CII]/L_FIR and L_CO/L_FIR ratios are similar to the values seen in nearby starburst galaxies. This suggests that MIPS J142824.0+352619 is a scaled-up version of a starburst nucleus, with the burst extended over several kiloparsecs., Comment: 6 pages, 3 figures, accepted by ApJ Letters
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- 2010
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29. Detection of the 13CO(J=6-5) Transition in the Starburst Galaxy NGC 253
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Hailey-Dunsheath, S., Nikola, T., Stacey, G. J., Oberst, T. E., Parshley, S. C., Bradford, C. M., Ade, P. A. R., and Tucker, C. E.
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Astrophysics - Abstract
We report the detection of 13CO(J=6-5) emission from the nucleus of the starburst galaxy NGC 253 with the redshift (z) and Early Universe Spectrometer (ZEUS), a new submillimeter grating spectrometer. This is the first extragalactic detection of the 13CO(J=6-5) transition, which traces warm, dense molecular gas. We employ a multi-line LVG analysis and find ~ 35% - 60% of the molecular ISM is both warm (T ~ 110 K) and dense (n(H2) ~ 10^4 cm^-3). We analyze the potential heat sources, and conclude that UV and X-ray photons are unlikely to be energetically important. Instead, the molecular gas is most likely heated by an elevated density of cosmic rays or by the decay of supersonic turbulence through shocks. If the cosmic rays and turbulence are created by stellar feedback within the starburst, then our analysis suggests the starburst may be self-limiting., Comment: 4 pages, 2 figures, accepted by ApJ Letters
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- 2008
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30. Anticipation of postmodern artistic practices in popular culture: The Beatles
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Božilović Nikola T. and Tasić Miloš B.
- Subjects
popular culture ,postmodernism ,pop-rock music ,the beatles ,intertwining of music styles ,Sociology (General) ,HM401-1281 - Abstract
The paper points to the disappearance of the division of art into 'high' and 'popular', with a particular emphasis on popular music, which under given circumstances adopts certain aesthetic standards of classical music forms. The authors also analyse the reverse process: the popularisation of classical music, in the composing-arranging and the performing sense. Particular attention is paid to the role, status and reach of popular culture/art in contemporary postmodern ventures. In this context, the Beatles represent a paradigmatic example, due to the fact that they used a plethora of postmodern creative procedures. The authors conduct an analysis of two characteristic Beatles' albums (Sgt. Pepper's Lonely Hearts Club Band and The Beatles, known as 'The White Album') that incorporate the key principles of postmodern aesthetics.
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- 2019
31. Detection of the 205 um [NII] Line from the Carina Nebula
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Oberst, T. E., Parshley, S. C., Stacey, G. J., Nikola, T., Loehr, A., Harnett, J. I., Tothill, N. F. H., Lane, A. P., Stark, A. A., and Tucker, C. E.
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Astrophysics - Abstract
We report the first detection of the 205 um 3P1 - 3P0 [NII] line from a ground-based observatory using a direct detection spectrometer. The line was detected from the Carina star formation region using the South Pole Imaging Fabry-Perot Interferometer (SPIFI) on the Antarctic Submillimeter Telescope and Remote Observatory (AST/RO) at South Pole. The [NII] 205 um line strength indicates a low-density (n ~ 32 cm^-3 ionized medium, similar to the low-density ionized halo reported previously in its [OIII] 52 and 88 um line emission. When compared with the ISO [CII] observations of this region, we find that ~27% of the [CII] line emission arises from this low-density ionized gas, but the large majority ~ 73% of the observed [CII] line emission arises from the neutral interstellar medium. This result supports and underpins prior conclusions that most of the observed [CII] 158 um line emission from Galactic and extragalactic sources arises from the warm, dense photodissociated surfaces of molecular clouds. The detection of the [NII] line demonstrates the utility of Antarctic sites for THz spectroscopy., Comment: 8 pages, 2 figures. To appear in the Astrophysical Journal Letters
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- 2006
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32. Warm Molecular Gas Traced with CO J=7->6 in the Galaxy's Central 2 Parsecs: Dynamical Heating of the Circumnuclear Disk
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Bradford, C. M., Stacey, G. J., Nikola, T., Bolatto, A. D., Jackson, J. M., Savage, M. L., and Davidson, J. A.
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Astrophysics - Abstract
We present an 11 arcsec resolution map of the central two parsecs of the Galaxy in the CO J =7->6 rotational transition. The CO emission shows rotation about Sgr A*, but also evidence for non-circular turbulent motion and a clumpy morphology. We combine our dataset with available CO measurements to model the physical conditions in the disk. We find that the molecular gas in the region is both warm and dense, with T~200-300 K, n_H2~50,000-70,000 cm^-3. The mass of warm molecular gas we measure in the central two parsecs is at least 2000 M_solar, about 20 times the UV-excited atomic gas mass, ruling out an UV heating scenario for the molecular material. We compare the available spectral tracers with theoretical models and conclude that molecular gas is heated with magneto-hydrodynamic shocks with v~10-20 kms and B~0.3-0.5 mG. Using the conditions derived with the CO analysis, we include the other important coolants--neutral oxygen and molecular hydrogen--to estimate the total cooling budget of the molecular material. We derive a mass to luminosity ratio of 2-3 M_solar/ L_solar, which is consistent with the total power dissipated via turbulent decay in 0.1 pc cells with v_rms~15 kms. These size and velocity scales are comparable to the observed clumping scale and the velocity dispersion. At this rate, the material near Sgr A* its dissipating its orbital energy on an orbital timescale, and cannot last for more than a few orbits. Our conclusions support a scenario in which the features near Sgr A* such as the CND and northern arm are generated by infalling clouds with low specific angular momentum., Comment: 31 pages, including 5 figures, accepted for publication in ApJ
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- 2005
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33. Synthesis of novel trans-4-(phthalimidomethyl)- and 4-(imidazol-1-ylmethyl)-3-indolyl-tetrahydroisoquinolinones as possible aromatase inhibitors
- Author
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Burdzhiev, Nikola T., Baramov, Todor I., Stanoeva, Elena R., Yanev, Stanislav G., Stoyanova, Tsveta D., Dimitrova, Diana H., and Kostadinova, Kristina A.
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- 2019
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34. Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics
- Author
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Boeszoermenyi, Andras, Chhabra, Sandeep, Dubey, Abhinav, Radeva, Denitsa L., Burdzhiev, Nikola T., Chanev, Christo D., Petrov, Ognyan I., Gelev, Vladimir M., Zhang, Meng, Anklin, Clemens, Kovacs, Helena, Wagner, Gerhard, Kuprov, Ilya, Takeuchi, Koh, and Arthanari, Haribabu
- Published
- 2019
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35. CO (J=7->6) Observations of NGC 253: Cosmic Ray Heated Warm Molecular Gas
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Bradford, C. M., Nikola, T., Stacey, G. J., Bolatto, A. D., Jackson, J. M., Savage, M. L., Davidson, J. A., and Higdon, S. J.
- Subjects
Astrophysics - Abstract
We report observations of the CO J=7->6 transition toward the starburst nucleus of NGC 253. This is the highest-excitation CO measurement in this source to date, and allows an estimate of the molecular gas excitation conditions. Comparison of the CO line intensities with a large velocity gradient, escape probability model indicates that the bulk of the 2-5 x 10^7 solar masses of molecular gas in the central 180 pc is highly excited. A model with T ~ 120 K, n_H_2 ~ 4.5 x 10^4 cm^-3 is consistent with the observed CO intensities as well as the rotational H2 lines observed with ISO. The inferred mass of warm, dense molecular gas is 10--30 times the atomic gas mass as traced through its [CII] and [OI] line emission. This large mass ratio is inconsistent with photodissociation region models where the gas is heated by far-UV starlight. It is also not likely that the gas is heated by shocks in outflows or cloud-cloud collisions. We conclude that the best mechanism for heating the gas is cosmic rays, which provide a natural means of uniformly heating the full volume of molecular clouds. With the tremendous supernova rate in the nucleus of NGC 253, the CR heating rate is at least ~800 times greater than in the Galaxy, more than sufficient to match the cooling observed in the CO lines., Comment: 12+ pages, 4 figures, to appear in The Astrophysical Journal (now includes tables)
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- 2002
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36. SPIFI: a direct-detection imaging spectrometer for submillimeter wavelengths
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Bradford, C. M., Stacey, G. J., Swain, M. R., Nikola, T., Bolatto, A. D., Jackson, J. M., Savage, M. L., Davidson, J. A., and Ade, P.
- Subjects
Astrophysics - Abstract
The South Pole Imaging Fabry-Perot Interferometer (SPIFI) is the first instrument of its kind -- a direct-detection imaging spectrometer for astronomy in the submillimeter band. SPIFI's focal plane is a square array of 25 silicon bolometers cooled to 60 mK; the spectrometer consists of two cryogenic, scanning Fabry-Perot interferometers in series with a 60 mK bandpass filter. The instrument operates in the short submillimeter windows (350 microns, 450 microns) available from the ground, with spectral resolving power selectable between 500 and 10000. At present, SPIFI's sensitivity is within a factor 1.5-3 of the photon background limit, comparable to the best heterodyne spectrometers. The instrument's large bandwidth and mapping capability provide substantial advantages for specific astrophysical projects, including deep extragalactic observations. In this article we present the motivation for and design of SPIFI and its operational characteristics on the telescope., Comment: 36 pages with 10 figures
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- 2002
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37. Star Formation in M51 Triggered by Galaxy Interaction
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Nikola, T., Geis, N., Herrmann, F., Madden, S. C., Poglitsch, A., Stacey, G. J., and Townes, C. H.
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Astrophysics - Abstract
We have mapped the inner 360'' regions of M51 in the 158micron [CII] line at 55'' spatial resolution using the Far-infrared Imaging Fabry-Perot Interferometer (FIFI) on the Kuiper Airborne Observatory (KAO). The emission is peaked at the nucleus, but is detectable over the entire region mapped, which covers much of the optical disk of the galaxy. There are also two strong secondary peaks at ~43% to 70% of the nuclear value located roughly 120'' to the north-east, and south-west of the nucleus. These secondary peaks are at the same distance from the nucleus as the corotation radius of the density wave pattern. The density wave also terminates at this location, and the outlying spiral structure is attributed to material clumping due to the interaction between M51 and NGC5195. This orbit crowding results in cloud-cloud collisions, stimulating star formation, that we see as enhanced [CII] line emission. The [CII] emission at the peaks originates mainly from photodissociation regions (PDRs) formed on the surfaces of molecular clouds that are exposed to OB starlight, so that these [CII] peaks trace star formation peaks in M51. The total mass of [CII] emitting photodissociated gas is ~2.6x10^{8} M_{sun}, or about 2% of the molecular gas as estimated from its CO(1-0) line emission. At the peak [CII] positions, the PDR gas mass to total gas mass fraction is somewhat higher, 3-17%, and at the secondary peaks the mass fraction of the [CII] emitting photodissociated gas can be as high as 72% of the molecular mass.... (continued), Comment: 14 pages, 6 figures, Accepted in ApJ (for higher resolution figures contact the author)
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- 2001
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38. CII Emission From NGC 4038/39 (The Antennae)
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Nikola, T., Genzel, R., Herrmann, F., Madden, S. C., Poglitsch, A., Geis, N., Townes, C. H., and Stacey, G. J.
- Subjects
Astrophysics - Abstract
We present observations of NGC 4038/39 in the [CII] 158 micron fine structure line taken with the MPE/UCB Far-infrared Imaging Fabry-Perot Interferometer (FIFI) on the KAO with 55" resolution. The total [CII] luminosity of the Antennae is 3.7x10^8 L(sun), which is about 1% of the FIR luminosity. The main part of the [CII] emission probably arises from photodissociation regions (PDRs). Up to 1/3 of the observed [CII] emission may originate from the CNM for higher temperatures and densities. From PDR models we derive densities and FUV intensities for the nuclei and the interaction zone. The minimum masses in the [CII] emitting regions in the interaction zone and the nuclei are a few x 10^(7) M(sun). We find that the [CII] to CO intensity ratio at the interaction zone is a factor of 2.6 lower than usually observed in starburst galaxies, but still a factor of about 1.3 to 1.4 higher than at the nuclei of NGC 4038/39, indicating no global starburst is taking place in the Antennae. [CII] emission arising partly from confined starburst regions and partly from surrounding quiescent clouds could explain the observed [CII] radiation at the interaction zone and the nuclei. There are small confined regions with high star formation activity in the interaction zone and with a lower star formation activity in the nuclei. This supports the high density and high FUV intensity for the PDRs in the interaction zone and the nuclei., Comment: Latex File 22 pages with 7 figures. Accepted by ApJ
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- 1998
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39. Occupational stress in emergency medical services
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Budimski Mihaela V., Momirović-Stojković Milena Z., Gavrilović Nikola T., and Jakšić-Horvat Kornelija I.
- Subjects
occupational stress emergency medical services ,burnout syndrome ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
INTRODUCTION: Occupational stress is connected with own profession. Commonly follows usually or unexpectedly pressures or responsibilities. AIM: Presenting ways in which working conditions can affect quality of life, and reflection on means of channeling occupational stress. METHOD: The results of a survey concerning occupational stress, conducted in April 2013. were analyzed. 200 physicians from 15 Emergency Medicine Services were meant to participate, but only ~50% of them (103 physicians from 12 centers) answered our questionnaire. Statistical analysis was performed with program spss 11 for windows. RESULTS: 54 (53%) of the total number of participants were females and 49 (47%) were males. The age structure showed the highest percentage of those between 31 and 40 years of age. The respondents declared themselves mainly as non-smokers - 87 (84%) and moderate alcohol consumers - 43 (42%). 9 (8,7%) of them admitted they need to take tranquilizers. Reviewing the health condition of the participants, we found that 31 of them (30%) had one or more chronic diseases. Low wages and public exposure had a great impact on physicians' attitude about their profession. Physicians without any stress related symptoms were present in the highest number - 31 (30%), while a minor group reported frequent fatigue and weariness - 23 (22%). For 39 people (38%), the best way for channeling occupational stress was an active use of free time, for 24 of them (23%) it was conversation with colleagues, and for 21 (20%) the solution was simply keeping to themselves. 64 (62%) respondents said that they take their professional problems home after work, and 25 (24%) said they forget about them when the shift ends. CONCLUSION: Working conditions do not have a significant impact on employees in Emergency Medicine Services. Occupational stress related symptoms are present in young doctors as well as in those older than 56 years. The most common ways for stress channeling are free activities and conversations with colleagues.
- Published
- 2017
40. Novel Tetrahydroisoquinoline-Based Heterocyclic Compounds Efficiently Inhibit SARS-CoV-2 Infection In Vitro
- Author
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Wang, Xi, primary, Burdzhiev, Nikola T., additional, Hu, Hengrui, additional, Li, Yufeng, additional, Li, Jiang, additional, Lozanova, Vesela V., additional, Kandinska, Meglena I., additional, and Wang, Manli, additional
- Published
- 2023
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41. Synthesis of Novel 1-Oxo-2,3,4-trisubstituted Tetrahydroisoquinoline Derivatives, Bearing Other Heterocyclic Moieties and Comparative Preliminary Study of Anti-Coronavirus Activity of Selected Compounds
- Author
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Kandinska, Meglena I., primary, Burdzhiev, Nikola T., additional, Cheshmedzhieva, Diana V., additional, Ilieva, Sonia V., additional, Grozdanov, Peter P., additional, Vilhelmova-Ilieva, Neli, additional, Nikolova, Nadya, additional, Lozanova, Vesela V., additional, and Nikolova, Ivanka, additional
- Published
- 2023
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42. Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors
- Author
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Markov, Nikola T., primary, Lindbergh, Cutter A., additional, Staffaroni, Adam M., additional, Perez, Kevin, additional, Stevens, Michael, additional, Nguyen, Khiem, additional, Murad, Natalia F., additional, Fonseca, Corrina, additional, Campisi, Judith, additional, Kramer, Joel, additional, and Furman, David, additional
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- 2022
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43. Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors
- Author
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Nikola T. Markov, Cutter A. Lindbergh, Adam M. Staffaroni, Kevin Perez, Michael Stevens, Khiem Nguyen, Natalia F. Murad, Corrina Fonseca, Judith Campisi, Joel Kramer, and David Furman
- Subjects
Adult ,Vascular Endothelial Growth Factor A ,Aging ,Multidisciplinary ,Humans ,Brain ,Cytokines ,Atrophy ,Research Personnel - Abstract
Aging is characterized by a progressive loss of brain volume at an estimated rate of 5% per decade after age 40. While these morphometric changes, especially those affecting gray matter and atrophy of the temporal lobe, are predictors of cognitive performance, the strong association with aging obscures the potential parallel, but more specific role, of individual subject physiology. Here, we studied a cohort of 554 human subjects who were monitored using structural MRI scans and blood immune protein concentrations. Using machine learning, we derived a cytokine clock (CyClo), which predicted age with good accuracy (Mean Absolute Error = 6 y) based on the expression of a subset of immune proteins. These proteins included, among others, Placenta Growth Factor (PLGF) and Vascular Endothelial Growth Factor (VEGF), both involved in angiogenesis, the chemoattractant vascular cell adhesion molecule 1 (VCAM-1), the canonical inflammatory proteins interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα), the chemoattractant IP-10 (CXCL10), and eotaxin-1 (CCL11), previously involved in brain disorders. Age, sex, and the CyClo were independently associated with different functionally defined cortical networks in the brain. While age was mostly correlated with changes in the somatomotor system, sex was associated with variability in the frontoparietal, ventral attention, and visual networks. Significant canonical correlation was observed for the CyClo and the default mode, limbic, and dorsal attention networks, indicating that immune circulating proteins preferentially affect brain processes such as focused attention, emotion, memory, response to social stress, internal evaluation, and access to consciousness. Thus, we identified immune biomarkers of brain aging which could be potential therapeutic targets for the prevention of age-related cognitive decline.
- Published
- 2022
44. RADFET as a sensor and dosimeter of gamma-ray irradiation.
- Author
-
Milic M. Pejovic, Momcilo M. Pejovic, and Nikola T. Nesic
- Published
- 2012
45. Investigation of memory effect by measurement of time delay of electrical breakdown in commercial gas-filled surge arresters.
- Author
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Momcilo M. Pejovic, Nikola T. Nesic, Milic M. Pejovic, and Natasa J. Bogdanovic
- Published
- 2012
46. INTER–ORGANIZATIONAL COLLABORATIVE CAPACITY OF PUBLIC SECTOR INSTITUTIONS’CONTROL ENTITIES IN EMERGENCY SITUATIONS
- Author
-
Nikola T. STOYANOV
- Subjects
collaboration ,collaborative capacity ,means ,Surface Measurement Overall Performance ,Military Science - Abstract
Environmental challenges and natural disasters demand new tools to support the performance of public institutions in emergency situations. This paper contributes to one of the fundamental objectives – inter–organizational collaboration, namely to the objective to share experience from the implementation of methods and tools and latest research results in support of management in the new security environment. In addition, it focuses on the cognitive and human aspects of collaboration. The goal of the paper is to investigate the impact of different factors and tools for understanding, explaining, and measuring collaborative capacity of public sector institutions’ control organism in emergency situations. The paper will present intermediate results from the research on “Inter–organizational collaborative capacity of public sector institutions’ control entities in emergency situations”. Based on a theoretical model, a draft instrument was developed (i.e., a questionnaire) for data collection that can be used to 1) investigate the impact of different factors, 2) localize inefficiencies in public sector institutions’ control organs, and 3) determine measures to achieve better organizational effectiveness of public sector institutions’ control entities in emergency situations.
- Published
- 2015
47. Beyond Traditional Use of Alchemilla vulgaris: Genoprotective and Antitumor Activity In Vitro
- Author
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Jelača, Sanja, primary, Dajić-Stevanović, Zora, additional, Vuković, Nenad, additional, Kolašinac, Stefan, additional, Trendafilova, Antoaneta, additional, Nedialkov, Paraskev, additional, Stanković, Miroslava, additional, Tanić, Nasta, additional, Tanić, Nikola T., additional, Acović, Aleksandar, additional, Mijatović, Sanja, additional, and Maksimović-Ivanić, Danijela, additional
- Published
- 2022
- Full Text
- View/download PDF
48. The impact of TP53 and RAS mutations on cerebellar glioblastomas
- Author
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Milinkovic, Vedrana P., Skender Gazibara, Milica K., Manojlovic Gacic, Emilija M., Gazibara, Tatjana M., and Tanic, Nikola T.
- Published
- 2014
- Full Text
- View/download PDF
49. SPIFI Imaging of the Galactic Center
- Author
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Stacey, G. J., Nikola, T., Bradford, C. M., Hall, L., Bolatto, A. D., Jackson, J. M., Savage, M. L., Davidson, J. A., Pfalzner, Susanne, editor, Kramer, Carsten, editor, Straubmeier, Christian, editor, and Heithausen, Andreas, editor
- Published
- 2004
- Full Text
- View/download PDF
50. CO (J = 7 → 6) Observations of NGC 253: Exited Molecular Gas in the Nucleus
- Author
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Bradford, C. M., Stacey, G. J., Nikola, T., Bolatto, A. D., Jackson, J. M., Pfalzner, Susanne, editor, Kramer, Carsten, editor, Straubmeier, Christian, editor, and Heithausen, Andreas, editor
- Published
- 2004
- Full Text
- View/download PDF
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