48 results on '"Nijhawan, Deepak"'
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2. Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3
3. Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
4. Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production
5. An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
6. Discovery and Optimization of N-Arylated Tetracyclic Dicarboximides That Target Primary Glioma Stem-like Cells
7. Biomarkers for RBM39 degradation in acute myeloid leukemia
8. MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth
9. Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15
10. Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820
11. Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers.
12. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
13. Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3
14. Exome Sequencing of Drug-Resistant Clones for Target Identification
15. Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
16. Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
17. P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage
18. β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
19. Cancer Vulnerabilities Unveiled by Genomic Loss
20. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models
21. Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase
22. A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins
23. Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers
24. Cytochrome c and dATP-dependent formation of Apaf-1/caspase 9 complex initiates an apoptotic protease cascade
25. Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I
26. Structural basis of recruitment of RBM39 to DCAF15 by a sulfonamide molecular glue E7820
27. Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification
28. Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase
29. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
30. Elimination of Mcl-1 is reguired for the initiation of apoptosis following ultraviolet irradiation
31. Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I.
32. β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
33. Selective targeting of mutant adenomatous polyposis coli ( APC ) in colorectal cancer
34. Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives
35. The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α
36. Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase
37. Abstract IA21: Developing a new functional classification of lung cancer based on tumor acquired vulnerabilities.
38. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.
39. RMRP Is a Non-Coding RNA Essential for Early Murine Development
40. Regulating TERT: Location, location, location
41. Mitochondrial activation of apoptosis
42. Apoptosis in Neural Development and Disease
43. Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs
44. Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade.
45. Molecular genetic basis of familial ALS.
46. Complementation Cloning of S2P, a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs
47. Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity.
48. Exome Sequencing of Drug-Resistant Clones for Target Identification.
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