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Your search keyword '"Nie, Yan-Hong"' showing total 8 results
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8 results on '"Nie, Yan-Hong"'

1. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2

Author

Liu, Zhen, Li, Xiao, Zhang, Jun-Tao, Cai, Yi-Jun, Cheng, Tian-Lin, Cheng, Cheng, Wang, Yan, Zhang, Chen-Chen, Nie, Yan-Hong, Chen, Zhi-Fang, Bian, Wen-Jie, Zhang, Ling, Xiao, Jianqiu, Lu, Bin, Zhang, Aue-fang, Zhang, Xiao-Di, Sang, Xiao, Wu, Jia-Jia, Xu, Xiu, Xiong, Zhi-Qi, Zhang, Feng, Yu, Xiang, Gong, Neng, Zhou, Wen-Hao, Sun, Qiang, and Qiu, Zilong

Subjects
Binding proteins -- Health aspects -- Genetic aspects, Genetic engineering -- Methods, Rett syndrome -- Genetic aspects -- Development and progression -- Models, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Methyl-CpG binding protein 2 (MeCP2) has crucial roles in transcriptional regulation and microRNA processing (1-4). Mutations in the MECP2 gene are found in 90% of patients with Rett syndrome, a [...]

Published
2016

4. One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs

Author

Zuo, Erwei, primary, Cai, Yi-Jun, additional, Li, Kui, additional, Wei, Yu, additional, Wang, Bang-An, additional, Sun, Yidi, additional, Liu, Zhen, additional, Liu, Jiwei, additional, Hu, Xinde, additional, Wei, Wei, additional, Huo, Xiaona, additional, Shi, Linyu, additional, Tang, Cheng, additional, Liang, Dan, additional, Wang, Yan, additional, Nie, Yan-Hong, additional, Zhang, Chen-Chen, additional, Yao, Xuan, additional, Wang, Xing, additional, Zhou, Changyang, additional, Ying, Wenqin, additional, Wang, Qifang, additional, Chen, Ren-Chao, additional, Shen, Qi, additional, Xu, Guo-Liang, additional, Li, Jinsong, additional, Sun, Qiang, additional, Xiong, Zhi-Qi, additional, and Yang, Hui, additional

Published
2017
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5. Homology-mediated end joining-based targeted integration using CRISPR/Cas9

Author

Yao, Xuan, primary, Wang, Xing, additional, Hu, Xinde, additional, Liu, Zhen, additional, Liu, Junlai, additional, Zhou, Haibo, additional, Shen, Xiaowen, additional, Wei, Yu, additional, Huang, Zijian, additional, Ying, Wenqin, additional, Wang, Yan, additional, Nie, Yan-Hong, additional, Zhang, Chen-Chen, additional, Li, Sanlan, additional, Cheng, Leping, additional, Wang, Qifang, additional, Wu, Yan, additional, Huang, Pengyu, additional, Sun, Qiang, additional, Shi, Linyu, additional, and Yang, Hui, additional

Published
2017
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8. Generation of mitochondrial replacement monkeys by female pronucleus transfer.

Author

Li CY, Liu XC, Li YZ, Wang Y, Nie YH, Xu YT, Zhang XT, Lu Y, and Sun Q

Subjects
Mice, Humans, Female, Animals, Haplorhini genetics, Mitochondria genetics, DNA, Mitochondrial genetics, Primates genetics, Mitochondrial Diseases genetics, Mitochondrial Diseases prevention & control, Mitochondrial Diseases veterinary, Rodent Diseases
Abstract

Mutations in mitochondrial DNA (mtDNA) are maternally inherited and have the potential to cause severe disorders. Mitochondrial replacement therapies, including spindle, polar body, and pronuclear transfers, are promising strategies for preventing the hereditary transmission of mtDNA diseases. While pronuclear transfer has been used to generate mitochondrial replacement mouse models and human embryos, its application in non-human primates has not been previously reported. In this study, we successfully generated four healthy cynomolgus monkeys ( Macaca fascicularis ) via female pronuclear transfer. These individuals all survived for more than two years and exhibited minimal mtDNA carryover (3.8%-6.7%), as well as relatively stable mtDNA heteroplasmy dynamics during development. The successful establishment of this non-human primate model highlights the considerable potential of pronuclear transfer in reducing the risk of inherited mtDNA diseases and provides a valuable preclinical research model for advancing mitochondrial replacement therapies in humans.

Published
2024
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