81 results on '"Neoplasms, Squamous Cell complications"'
Search Results
2. Fibroepithelial urethral polyp with minor prostatic glands in an older man.
- Author
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Yorita K, Naroda T, and Tamura M
- Subjects
- Male, Adult, Humans, Prostate pathology, Urethra pathology, Prostate-Specific Antigen, Urethral Neoplasms pathology, Urinary Retention complications, Neoplasms, Squamous Cell complications, Polyps pathology
- Abstract
We describe a man in his 60s with an incidentally detected urethral polyp located in the middle section of his penile shaft. The patient had been suffering from urinary retention for 9 years due to benign prostatic hyperplasia. He was initiated on clean intermittent catheterisation to drain urine 1 year before the detection of the urethral polyp. Holmium laser nucleation of the prostate was performed, and an anterior urethral polyp (5 mm in diameter) was resected. Pathology indicated that the urethral polyp was a fibroepithelial polyp with prostate-specific antigen-immunoreactive heterotopic prostatic glands. There were no problems with urination 6 months after surgery. Fibroepithelial urethral polyps are usually congenital and are rarely described in adults. The clinicopathological features of this polyp, with its uniquely associated minor prostatic glands, are presented., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
- Full Text
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3. Clinical impact of SARS-CoV-2 infection among patients with vulvar cancer: the Gemelli Vul.Can multidisciplinary team.
- Author
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Federico A, Fragomeni SM, Tagliaferri L, Guajardo Rios LS, Lancellotta V, Gentileschi S, Corrado G, Gui B, Colloca G, Rufini V, Fagotti A, Scambia G, and Garganese G
- Subjects
- Adult, Aged, Aged, 80 and over, Fatal Outcome, Female, Humans, Middle Aged, Neoplasms, Squamous Cell therapy, Retrospective Studies, Vulvar Neoplasms therapy, COVID-19 complications, Neoplasms, Squamous Cell complications, Time-to-Treatment, Vulvar Neoplasms complications
- Abstract
Background: 'Severe acute respiratory syndrome coronavirus-2' (SARS-CoV-2) infection has dramatically affected the management of patients with cancer, who are most vulnerable to the consequences of the infection. Patients with vulvar cancer are frequently elderly and affected by multiple co-morbidities, thus representing a particularly frail population., Objective: To assess the clinical impact of the SARS-CoV-2 infection among patients scheduled for treatment for active vulvar cancer., Methods: Data on patients with vulvar tumors referred to Fondazione Policlinico Universitario Agostino Gemelli IRCCS between February 2020 and July 2021 were retrospectively analyzed. Patients with a positive reverse transcription polymerase chain reaction in nasopharyngeal swab were considered as positive for SARS-Cov-2., Results: One hundred and ninety-one patients with vulvar cancer were evaluated and scheduled for treatment. The median age was 72 years (range 35-94). Seven (3.7%) patients were diagnosed with SARS-Cov-2 infection: three (42.9%) had their treatment delayed, with no apparent consequences, two (28.6%) had their treatment delayed and later abandoned because of clinical worsening due to oncologic disease progression, and two (28.6%) contracted the infection in the post-operative period and died due to respiratory complications., Conclusions: In most cases the infection had major clinical implications, being associated with significant delays in oncologic treatments and extremely high mortality when contracted in the post-operative period., Competing Interests: Competing interests: None declared., (© IGCS and ESGO 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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4. Pretreatment Adherence to a Priori-Defined Dietary Patterns Is Associated with Decreased Nutrition Impact Symptom Burden in Head and Neck Cancer Survivors.
- Author
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Maino Vieytes CA, Mondul AM, Crowder SL, Zarins KR, Edwards CG, Davis EC, Wolf GT, Rozek LS, Arthur AE, and On Behalf Of The University Of Michigan Head And Neck Spore Program
- Subjects
- Adult, Aged, Aged, 80 and over, Diet Surveys, Diet, Healthy, Female, Humans, Male, Middle Aged, Nutrition Disorders prevention & control, Nutritional Status, Cancer Survivors statistics & numerical data, Diet statistics & numerical data, Head and Neck Neoplasms complications, Neoplasms, Squamous Cell complications, Nutrition Disorders etiology
- Abstract
Dietary intake is understood to contribute to nutrition impact symptoms (NIS) in patients with head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to evaluate the performance of four a priori-defined diet quality indices on the presence of NIS 1 year following diagnosis using data on 323 participants from the University of Michigan Head and Neck Specialized Program of Research Excellence (UM-SPORE). Pretreatment dietary intake was measured before treatment initiation using a food frequency questionnaire. NIS were measured along seven subdomains. Multivariable binary logistic regression models were constructed to evaluate relationships between pretreatment scores on a priori-defined diet quality indices (AHEI-2010, aMED, DASH, and a low-carbohydrate score) and the presence of individual symptoms in addition to a composite "symptom summary score" 1-year postdiagnosis. There were several significant associations between different indices and individual NIS. For the symptom summary score, there were significant inverse associations observed for aMED (OR
Q5-Q1 : 0.36, 95% CI: 0.14-0.88, ptrend = 0.04) and DASH (ORQ5-Q1 : 0.38, 95% CI: 0.15-0.91, ptrend = 0.02) and the presence of NIS 1-year postdiagnosis. Higher adherence to the aMED and DASH diet quality indices before treatment may reduce NIS burden at 1-year postdiagnosis.- Published
- 2021
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5. Assessment of Intratumoral and Peritumoral Computed Tomography Radiomics for Predicting Pathological Complete Response to Neoadjuvant Chemoradiation in Patients With Esophageal Squamous Cell Carcinoma.
- Author
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Hu Y, Xie C, Yang H, Ho JWK, Wen J, Han L, Chiu KWH, Fu J, and Vardhanabhuti V
- Subjects
- Adult, Area Under Curve, Esophageal Neoplasms complications, Female, Hong Kong, Humans, Male, Middle Aged, Neoadjuvant Therapy methods, Neoadjuvant Therapy statistics & numerical data, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell therapy, Polymerase Chain Reaction methods, ROC Curve, Tomography, X-Ray Computed, Esophageal Neoplasms therapy, Neoadjuvant Therapy standards
- Abstract
Importance: For patients with locally advanced esophageal squamous cell carcinoma, neoadjuvant chemoradiation has been shown to improve long-term outcomes, but the treatment response varies among patients. Accurate pretreatment prediction of response remains an urgent need., Objective: To determine whether peritumoral radiomics features derived from baseline computed tomography images could provide valuable information about neoadjuvant chemoradiation response and enhance the ability of intratumoral radiomics to estimate pathological complete response., Design, Setting, and Participants: A total of 231 patients with esophageal squamous cell carcinoma, who underwent baseline contrast-enhanced computed tomography and received neoadjuvant chemoradiation followed by surgery at 2 institutions in China, were consecutively included. This diagnostic study used single-institution data between April 2007 and December 2018 to extract radiomics features from intratumoral and peritumoral regions and established intratumoral, peritumoral, and combined radiomics models using different classifiers. External validation was conducted using independent data collected from another hospital during the same period. Radiogenomics analysis using gene expression profile was done in a subgroup of the training set for pathophysiological explanation. Data were analyzed from June to December 2019., Exposures: Computed tomography-based radiomics., Main Outcomes and Measures: The discriminative performances of radiomics models were measured by area under the receiver operating characteristic curve., Results: Among the 231 patients included (192 men [83.1%]; mean [SD] age, 59.8 [8.7] years), the optimal intratumoral and peritumoral radiomics models yielded similar areas under the receiver operating characteristic curve of 0.730 (95% CI, 0.609-0.850) and 0.734 (0.613-0.854), respectively. The combined model was composed of 7 intratumoral and 6 peritumoral features and achieved better discriminative performance, with an area under the receiver operating characteristic curve of 0.852 (95% CI, 0.753-0.951), accuracy of 84.3%, sensitivity of 90.3%, and specificity of 79.5% in the test set. Gene sets associated with the combined model mainly involved lymphocyte-mediated immunity. The association of peritumoral area with response identification might be partially attributed to type I interferon-related biological process., Conclusions and Relevance: A combination of peritumoral radiomics features appears to improve the predictive performance of intratumoral radiomics to estimate pathological complete response after neoadjuvant chemoradiation in patients with esophageal squamous cell carcinoma. This study underlines the significant application of peritumoral radiomics to assess treatment response in clinical practice.
- Published
- 2020
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6. AA amyloidosis associated with pulmonary squamous cell carcinoma treated with chemoradiation and immune checkpoint inhibitor therapy.
- Author
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Mo H, Yau D, Mirshahidi H, Guadiz T, Zuppan CW, and Magaki S
- Subjects
- Aged, 80 and over, Chemoradiotherapy methods, Female, Humans, Immune Checkpoint Inhibitors therapeutic use, Nivolumab therapeutic use, Amyloidosis complications, Lung Neoplasms complications, Lung Neoplasms therapy, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell therapy
- Published
- 2020
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7. Left atrial tumor thrombus with emboli to the brain and distal extremities: A case report.
- Author
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Layfield LJ, Freeman D, and Crim JR
- Subjects
- Extremities, Fatal Outcome, Humans, Male, Middle Aged, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell pathology, Thrombosis etiology, Thrombosis pathology, Tonsillar Neoplasms complications, Tonsillar Neoplasms pathology, Heart Atria pathology, Neoplastic Cells, Circulating pathology, Stroke etiology
- Abstract
Cardiac metastases are an uncommon phenomenon associated with neoplasms from a variety of primary sites. Pulmonary involvement often accompanies metastases involving the left atrium or ventricle and clinical presentation may be associated with stroke or emboli involving distal sites. We report a patient who presented acutely to the Emergency Department with symptoms of a cerebrovascular accident and bilateral cold pulseless lower extremities. Computerized Tomographic (CT) angiogram of the chest, abdomen, pelvis and lower extremities disclosed pulmonary veins with large filling defects in the right superior and inferior vessels as well as the left atrium and atrial appendage. Mediastinal and hilar adenopathy was detected. The patient had a history of tonsillar squamous cell carcinoma eighteen months prior. The patient underwent operative intervention with removal of a large left intra-atrial mass, histologic evaluation of which demonstrated groups of malignant squamous cells meshed in fibrin clot. The patient died three days post operatively due to multiple brain infarctions., (Copyright © 2020. Published by Elsevier GmbH.)
- Published
- 2020
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8. Broncho-oesophageal fistula after lung cancer treatment.
- Author
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Sugimoto H, Yoshihara A, Obata D, and Sugimoto K
- Subjects
- Aged, Cough, Fatal Outcome, Humans, Lung Neoplasms radiotherapy, Male, Neoplasms, Squamous Cell radiotherapy, Bronchial Fistula etiology, Esophageal Fistula etiology, Lung Neoplasms complications, Neoplasms, Squamous Cell complications
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2020
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9. Erythroderma as first manifestation of squamous cell lung cancer: rare case report.
- Author
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Arandes-Marcocci J, Iglesias-Sancho M, Setó-Torrent N, and Fernández-Figueras MT
- Subjects
- Aged, Biopsy, Dermatitis, Exfoliative etiology, Erythema pathology, Humans, Lung Neoplasms complications, Male, Neoplasms, Squamous Cell complications, Paraneoplastic Syndromes pathology, Tomography, X-Ray Computed, Dermatitis, Exfoliative pathology, Lung Neoplasms pathology, Neoplasms, Squamous Cell pathology
- Abstract
Erythroderma as the first manifestation of a solid organ malignancy is rare. The underlying cancer is a challenging condition to diagnose. There are a few cases of erythroderma in cancer patients reported in the literature. We here describe the case of a 70-year-old man who presented with asthenia, weight loss, dry cough and total body erythema with desquamation over the past month. A chest computed tomography scan showed a nodular lesion, which was finally diagnosed as a squamous cell lung carcinoma. To our knowledge, as an erythroderma presentation, only 13 cases have been reported in the literature. This case report demonstrates the need to search for a neoplasm in patients presenting with erythroderma, particularly in the presence of accompanying debilitating symptoms., (Copyright © 2019 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2020
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10. Perineural invasion in oral cancer: challenges, controversies and clinical impact.
- Author
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da Silva SD and Kowalski LP
- Subjects
- Female, Humans, Male, Mouth Neoplasms pathology, Neoplasm Invasiveness, Neoplasms, Squamous Cell pathology, Mouth Neoplasms complications, Neoplasms, Squamous Cell complications
- Published
- 2019
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11. Immunotherapy in SCLC: Exceptional Clinical Benefit and Abscopal Pneumonitis After Radiotherapy.
- Author
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Bonanno L, Pavan A, Attili I, Pasello G, and Guarneri V
- Subjects
- Aged, Humans, Male, Neoplasms, Squamous Cell complications, Immunotherapy methods, Lung Neoplasms complications, Lung Neoplasms radiotherapy, Neoplasms, Squamous Cell radiotherapy, Pneumonia etiology
- Published
- 2019
- Full Text
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12. Chronic Obstructive Pulmonary Disease in Lung Cancer Patients: Prevalence, Underdiagnosis, and Clinical Characterization.
- Author
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Mouronte-Roibás C, Leiro-Fernández V, Ruano-Raviña A, Ramos-Hernández C, Abal-Arca J, Parente-Lamelas I, Botana-Rial M, Priegue-Carrera A, and Fernández-Villar A
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Pulmonary Disease, Chronic Obstructive diagnosis, Spain epidemiology, Adenocarcinoma complications, Lung Neoplasms complications, Neoplasms, Squamous Cell complications, Pulmonary Disease, Chronic Obstructive complications, Pulmonary Disease, Chronic Obstructive epidemiology
- Abstract
Background: Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are associated with increased morbidity and mortality. The differential clinical and functional features among LC patients with or without COPD have not been defined., Objectives: The aims of this study were to examine the prevalence and underdiagnosis rate of COPD in LC patients and to compare the clinical and functional features of LC patients with and without COPD., Methods: We designed a multicenter hospital-based study including all LC cases diagnosed from January 2014 to August 2016. We assessed epidemiological, clinical, radiological, functional, and histological variables in all cases., Results: We recruited 602 patients with LC, most of them men (77.9%), with a median age of 67 ± 15 years. The COPD prevalence among LC patients was 51.5%, with a underdiagnosis rate of 71.6%. The LC+COPD patients were older and the proportion of men was higher compared with the LC-only patients. The LC+COPD patients had more pack-years, more squamous LC, a lower monoxide transfer coefficient (KCO), and higher Charlson index scores than patients with LC only. The median survival of LC-only patients was 37% longer than that of LC+COPD patients (22 vs. 16 months), but this difference was not statistically significant., Conclusions: Among LC patients, COPD is prevalent and underdiagnosed. Patients with LC+COPD more often have squamous LC, have greater comorbidities, and have a lower KCO. More effort should be made for an early diagnosis of COPD to select patients at higher risk of developing LC., (© 2018 S. Karger AG, Basel.)
- Published
- 2018
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13. Impact of pre-operative body mass index in head and neck cancer patients undergoing microvascular reconstruction.
- Author
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Hyun DJ, Joo YH, and Kim MS
- Subjects
- Aged, Female, Free Tissue Flaps surgery, Head and Neck Neoplasms complications, Head and Neck Neoplasms mortality, Humans, Kaplan-Meier Estimate, Male, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell mortality, Obesity complications, Postoperative Complications etiology, Plastic Surgery Procedures adverse effects, Plastic Surgery Procedures mortality, Retrospective Studies, Treatment Failure, Body Mass Index, Head and Neck Neoplasms surgery, Microvessels surgery, Neoplasms, Squamous Cell surgery, Plastic Surgery Procedures methods
- Abstract
Objectives: To analyse the relationship of pre-operative body mass index with surgical complications and oncological outcomes in patients undergoing microvascular reconstruction for head and neck squamous cell cancer., Method: A retrospective review was conducted of 259 patients who underwent microvascular free flap reconstruction after head and neck ablative surgery., Results: Mean body mass index was 22.48 kg/m2. There were no correlations between body mass index and: flap failure (p = 0.739), flap ischaemia (p = 0.644), pharyngocutaneous fistula (p = 0.141) or wound infection (p = 0.224). The five-year disease-specific survival rate was 63 per cent. On univariate analysis, the five-year disease-specific survival rate was significantly correlated with pre-operative body mass index, based on Kaplan-Meier survival curves (p = 0.028). The five-year disease-specific survival rates in underweight, normal weight, overweight and obese groups were 47 per cent, 55 per cent, 65 per cent and 80 per cent, respectively., Conclusion: Pre-operative body mass index was a useful predictor for recurrence and survival in patients who underwent microvascular reconstruction for head and neck squamous cell cancer.
- Published
- 2017
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14. Lymphoepithelioma-like carcinoma of the urinary bladder: A case report.
- Author
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Laforga JB and Gasent JM
- Subjects
- Aged, 80 and over, Biomarkers, Tumor analysis, Carcinoma, Transitional Cell chemistry, Carcinoma, Transitional Cell complications, Diagnosis, Differential, Female, Hematuria etiology, Humans, Immunohistochemistry, Lymphocytes, Tumor-Infiltrating pathology, Neoplasm Invasiveness, Neoplasms, Squamous Cell chemistry, Neoplasms, Squamous Cell complications, Prognosis, Urinary Bladder Neoplasms chemistry, Urinary Bladder Neoplasms complications, Carcinoma, Transitional Cell pathology, Neoplasms, Squamous Cell pathology, Urinary Bladder Neoplasms pathology
- Abstract
We report a case of lymphoepithelioma-like carcinoma of the urinary bladder in an elderly female patient. A 97-year old woman presented with hematuria, and an ultrasonographic urinary study showed a localized tumor in the trigone region of the urinary bladder. A transurethral resection revealed a mixed tumor formed by high-grade transitional carcinoma and lymphoepithelioma-like carcinoma that had infiltrated into the muscular propria. We describe the clinicopathological, morphological and immunohistochemical features of this tumor and briefly discuss its differential diagnosis and biological behavior., (Copyright © 2016 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2017
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15. Coexisting osseous choristoma mimicking advanced stage disease in a tonsil cancer patient: a case report.
- Author
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Linxweiler M, Schick B, Wolf G, and Veith C
- Subjects
- Calcinosis complications, Choristoma complications, Humans, Male, Middle Aged, Calcinosis diagnosis, Choristoma diagnosis, Neoplasms, Squamous Cell complications, Palatine Tonsil, Tonsillar Neoplasms complications
- Published
- 2016
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16. Gene Variability Between Perineural-positive and Perineural-negative Squamous Cell Skin Cancers.
- Author
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Mays AC, Chou J, Craddock AL, Miller L, and Browne JD
- Subjects
- Bayes Theorem, Biomarkers, Tumor biosynthesis, Biomarkers, Tumor genetics, Epithelial Cells pathology, Gene Expression Regulation, Neoplastic, Humans, Neoplasm Invasiveness genetics, Neoplasm Invasiveness pathology, Neoplasm Proteins genetics, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell pathology, Nerve Sheath Neoplasms complications, Nerve Sheath Neoplasms pathology, Oligonucleotide Array Sequence Analysis methods, Skin Neoplasms complications, Skin Neoplasms pathology, Support Vector Machine, Neoplasm Proteins biosynthesis, Neoplasms, Squamous Cell genetics, Nerve Sheath Neoplasms genetics, Skin Neoplasms genetics
- Abstract
Aim: To identify differentially expressed genes (DEGs) between perineural invasion-positive (PP) and -negative (PN) cutaneous squamous cell cancers (CSCC)., Materials/methods: Forty CSCC samples with and without perineural invasion were processed for RNA isolation and hybridization to Affymetrix-U219 DNA microarrays. Raw gene expression data were normalized by Robust Multi-array Averaging (RMA) and log2 transformed. Gene expression-based classification models were created and accuracies evaluated using leave-one-out cross-validation., Results: At a stringent limma p-value (p<0.001), 24 genes were differentially expressed between PP and PN samples. The cross-validated performance of the eight classification models exhibited a mean accuracy of 85-95%. Diagonal linear discriminant was most accurate at 95%, followed by Bayesian compound covariate at 94%. The poorest accuracy (85%) was observed for 1-Nearest neighbor and Support vector machines., Conclusion: Gene expression may distinguish between PP and PN CSCC. Understanding these gene patterns may potentiate more timely diagnosis of perineural invasion and guide comprehensive therapies., (Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Published
- 2016
17. Acute abdomen caused by spontaneous perforation of pyometra in a patient with cervical cancer.
- Author
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Kroon HM and Smolders RG
- Subjects
- Abdomen, Acute diagnostic imaging, Abdomen, Acute surgery, Aged, Female, Humans, Neoplasms, Squamous Cell diagnostic imaging, Neoplasms, Squamous Cell surgery, Pyometra diagnostic imaging, Pyometra surgery, Spontaneous Perforation diagnostic imaging, Spontaneous Perforation surgery, Tomography, X-Ray Computed, Uterine Cervical Neoplasms diagnostic imaging, Uterine Cervical Neoplasms surgery, Uterine Perforation diagnostic imaging, Uterine Perforation surgery, Abdomen, Acute etiology, Neoplasms, Squamous Cell complications, Pyometra complications, Spontaneous Perforation complications, Uterine Cervical Neoplasms complications, Uterine Perforation complications
- Published
- 2016
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18. Rare cause of atrial fibrillation: a thymic mass.
- Author
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Vishwanathan S, Tayshetye P, Bilimoria F, and Finley G
- Subjects
- Echocardiography, Transesophageal, Humans, Image-Guided Biopsy, Male, Middle Aged, Neoplasms, Squamous Cell pathology, Neoplasms, Squamous Cell therapy, Pulmonary Edema complications, Thymus Neoplasms pathology, Thymus Neoplasms therapy, Tomography, X-Ray Computed, Atrial Fibrillation etiology, Neoplasms, Squamous Cell complications, Thymus Neoplasms complications
- Abstract
A 62-year-old African-American man admitted to the emergency room with chest pain and exertional dyspnoea. He was found to be in rapid atrial fibrillation with pulmonary oedema. A transoesophageal echocardiogram performed prior to cardioversion showed a depressed left ventricular function (ejection fraction 30%) and an extracardiac heterogeneous echodensity compressing the right atrium and the superior vena cava. CT of the chest confirmed an anterior mediastinal mass measuring 13.5×6.6×10.1 cm, exerting a mass effect on the right atrium with mediastinal and right hilar adenopathy. CT-guided biopsy of the mediastinal mass revealed thymic carcinoma (squamous cell subtype). The metastatic workup was negative. The mass was deemed surgically unresectable due to its proximity to the heart. Chemotherapy was initiated with carboplatin/paclitaxel every 3 weeks with plans for intensity modulated radiotherapy after one to two cycles of chemotherapy. The patient recently had a repeat CT scan of the chest showing regression of the tumour., (2016 BMJ Publishing Group Ltd.)
- Published
- 2016
- Full Text
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19. A Rare Cause of Dysphagia: Squamous Papillomatosis of the Esophagus.
- Author
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Corredine TJ, Bortniker E, and Birk J
- Subjects
- Aged, Esophageal Neoplasms complications, Esophageal Neoplasms pathology, Esophagoscopy, Female, Histocytochemistry, Humans, Microscopy, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell pathology, Papilloma complications, Papilloma pathology, Deglutition Disorders etiology, Deglutition Disorders pathology, Esophageal Neoplasms diagnosis, Esophagus pathology, Neoplasms, Squamous Cell diagnosis, Papilloma diagnosis
- Published
- 2016
- Full Text
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20. Administration of chemotherapy in patients on dialysis.
- Author
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Kuo JC and Craft PS
- Subjects
- Aged, Carcinoma, Squamous Cell complications, Carcinoma, Squamous Cell drug therapy, Female, Humans, Kidney Failure, Chronic complications, Liver Neoplasms drug therapy, Liver Neoplasms secondary, Lung Neoplasms complications, Lung Neoplasms drug therapy, Male, Middle Aged, Neoplasms complications, Neoplasms, Germ Cell and Embryonal complications, Neoplasms, Germ Cell and Embryonal drug therapy, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell drug therapy, Parotid Neoplasms complications, Parotid Neoplasms drug therapy, Parotid Neoplasms pathology, Skin Neoplasms complications, Skin Neoplasms drug therapy, Small Cell Lung Carcinoma complications, Small Cell Lung Carcinoma drug therapy, Testicular Neoplasms complications, Testicular Neoplasms drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Kidney Failure, Chronic therapy, Neoplasms drug therapy, Renal Dialysis
- Abstract
The prevalence of patients on dialysis has increased and these patients present a challenge for chemotherapy administration when diagnosed with cancer. A consensus on the dosage and timing of different chemotherapeutic agents in relation to dialysis has not been established. We describe the pattern of care and treatment outcome for cancer patients on dialysis in our institution. The dataset from the Australia and New Zealand Dialysis and Transplant Registry of patients on dialysis who had a diagnosis of cancer was obtained and matched to the pharmacy records in our institution to identify patients who had received chemotherapy while on dialysis. Relevant clinical information including details of the dialysis regimen, chemotherapy administration and adverse events was extracted for analysis. Between July 1999 and July 2014, 21 patients on dialysis were included for analysis. Five (23.8%) received chemotherapy, most of which was administered before dialysis sessions. As a result of adverse events, one patient discontinued treatment; two other patients required dose reduction or treatment delay. Chemotherapy administration was feasible in cancer patients on dialysis, but chemotherapy usage was low. Better understanding of the altered pharmacokinetics in patients on dialysis may improve chemotherapy access and practice.
- Published
- 2015
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21. Eczema as the first manifestation of a lung cancer.
- Author
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Meng X, Wang R, Huang Z, and Yu J
- Subjects
- Eczema etiology, Humans, Lung Neoplasms complications, Lung Neoplasms pathology, Male, Middle Aged, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell pathology, Paraneoplastic Syndromes etiology, Radiography, Eczema diagnosis, Lung Neoplasms diagnostic imaging, Neoplasms, Squamous Cell diagnostic imaging, Paraneoplastic Syndromes diagnosis
- Abstract
Lung cancer combined with eczema is a rare disease. We report a case of 58-year-old man with eczema as the first manifestation of a lung cancer. Skin examination revealed diffuse erythema, dander, itchy rash, and scratch. Chest contrast-enhanced computed tomography showed a heterogeneously enhanced irregular mass in the right lung. Punch biopsy of the tumor confirms squamous cell lung cancer. Eczema vanished nearly completely after one cycle of chemotherapy.
- Published
- 2015
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22. [Stent graft for rapidly growing thoracic mycotic aneurysm in a patient with advanced lung cancer].
- Author
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Ikeuchi M, Ando M, Hisano K, Nakamura R, Urabe Y, and Uchida T
- Subjects
- Aged, Aneurysm, Infected microbiology, Aorta, Thoracic, Humans, Male, Tomography, X-Ray Computed, Aneurysm, Infected therapy, Escherichia coli Infections complications, Lung Neoplasms complications, Neoplasms, Squamous Cell complications, Stents
- Abstract
We report a compromised patient with mycotic aneurysm, who was successfully treated by urgent placement of a stent graft. A man in his seventies was admitted to our hospital with relapsing high fever and back pain during chemotherapy for advanced squamous cell carcinoma of the lung. Contrast CT demonstrated a saccular aneurysm of the thoracic aorta and left pleural effusion. Blood cultures were positive for Escherichia coli producing extended spectrum beta-lactamase (ESBL). Therefore, thoracic mycotic aneurysm was diagnosed. Because of rapid growth on consecutive examinations, absolute bed rest was required. Therefore, we performed antibiotic therapy combined with stent graft placement, which achieved complete exclusion of the aneurysm. He was discharged in an ambulatory state, and his quality of life remained good at home until just before death from terminal state of the cancer.
- Published
- 2015
23. [Reinforcement of warfarin action in a patient administered S-1].
- Author
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Watanabe H, Itoh H, Tsuchiya Y, Miyagi N, Sugiyama T, Nakai Y, Shinozaki Y, Noguchi T, Jinbu Y, and Kusama M
- Subjects
- Aged, Antimetabolites, Antineoplastic therapeutic use, Cardiomyopathy, Hypertrophic complications, Cerebral Infarction complications, Drug Combinations, Drug Interactions, Humans, Male, Mouth Neoplasms complications, Neoplasms, Squamous Cell complications, Oxonic Acid therapeutic use, Tachycardia, Ventricular complications, Tegafur therapeutic use, Anticoagulants therapeutic use, Cardiomyopathy, Hypertrophic drug therapy, Cerebral Infarction drug therapy, Mouth Neoplasms drug therapy, Neoplasms, Squamous Cell drug therapy, Tachycardia, Ventricular drug therapy, Warfarin therapeutic use
- Abstract
A case showing reinforcement of the action of warfarin and potassium in a patient administered S-1 is reported.The patient was a 71-year-old man with left upper gingival cancer.He had ventricular tachycardia (VT), hypertrophic cardiomyopathy, and a cerebellar infarction.He underwent a pacemaker implantation, and was administered warfarin.After the operation, in mid-March 2010, he was administered with S-1 and warfarin. However, the international normalized ratio of prothrombin time (PT-INR) increased to an extremely high level of 5.82, and S-1 and warfarin were stopped. They were re-administered at the end of April, and the PT-INR stabilized to approximately 2.
- Published
- 2015
24. Effect of swallowing training on dysphagia and depression in postoperative tongue cancer patients.
- Author
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Zhang L, Huang Z, Wu H, Chen W, and Huang Z
- Subjects
- Aged, Aged, 80 and over, Depressive Disorder therapy, Female, Glossectomy adverse effects, Glossectomy education, Humans, Male, Middle Aged, Patient Education as Topic, Postoperative Period, Prospective Studies, Quality of Life, Tongue Neoplasms surgery, Treatment Outcome, Deglutition Disorders etiology, Deglutition Disorders rehabilitation, Depressive Disorder etiology, Glossectomy rehabilitation, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell surgery, Tongue Neoplasms complications
- Abstract
Purpose: The aim of the present study was to evaluate the effect of swallowing training on dysphagia and depression in postoperative tongue cancer patients., Method: Fifty-eight tongue cancer patients aged 45-81 years participated in the present study. All patients were scheduled to undergo partial tongue resection and flap rehabilitation. Changes in dysphagia and depression before and after swallowing training were measured. The water swallow test (WST) and the Zung Self-Rating Depression Scale (SDS) were used to evaluate the severity of dysphagia and depression, respectively., Results: The WST level and SDS scores in the less than 50% tongue resection and rehabilitation group were significantly lower than those of the greater than 50% group. The WST level and SDS scores of the early tumor stage group were significantly lower than those of the advanced tumor stage group. WST levels and SDS scores before swallowing training were significantly greater than those measured after swallowing training. In all cases, lower WST levels were associated with lower SDS scores., Conclusions: Postoperative dysphagia, depression and anxiety were improved after swallowing training. Early identification and management of dysphagia can improve treatment outcomes and reduce depression., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
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25. Sleep-related breathing disorders in patients with tumors in the head and neck region.
- Author
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Faiz SA, Balachandran D, Hessel AC, Lei X, Beadle BM, William WN Jr, and Bashoura L
- Subjects
- Adult, Aged, Aged, 80 and over, Continuous Positive Airway Pressure, Fatigue etiology, Female, Head and Neck Neoplasms radiotherapy, Humans, Logistic Models, Male, Middle Aged, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell radiotherapy, Polysomnography, Retrospective Studies, Sleep Apnea, Obstructive therapy, Sleep Wake Disorders therapy, Head and Neck Neoplasms complications, Sleep Apnea, Obstructive etiology, Sleep Wake Disorders etiology
- Abstract
Background: Sleep disturbance is a prominent complaint of cancer patients. Most studies have focused on insomnia and cancer-related fatigue. Obstructive sleep apnea (OSA) has been reported in small studies and case reports., Methods: In a retrospective review of patients who underwent formal sleep evaluation and polysomnography (PSG) from 2006 to 2011, 56 patients with tumors in the head and neck region were identified. Clinical characteristics, sleep-related history, and PSG data were reviewed., Results: Most patients had active cancer (80%), and the majority had squamous pathology (68%). Prominent symptoms included daytime fatigue (93%), daytime sleepiness (89%), and snoring (82%). Comorbid conditions primarily included hypertension (46%) and hypothyroidism (34%). Significant sleep-related breathing disorder was noted in 93% of patients, and 84% met clinical criteria for OSA. A male predominance (77%) was noted, and patients were not obese (body mass index <30 kg/m(2) in 52%). The majority of patients (79%) underwent radiation prior to sleep study, of which 88% had OSA, and in the group without prior radiation, 67% had OSA. Adherence to positive airway pressure (PAP) therapy was slightly better when compared with the general population. A subset of patients with persistent hypoxia despite advanced forms of PAP required tracheostomy. Multivariate analysis revealed that patients with active disease and radiation prior to PSG were more likely to have OSA., Conclusion: Sleep-related breathing disorder was common in patients with tumors in the head and neck region referred for evaluation of sleep disruption, and most met clinical criteria for OSA. Daytime fatigue and sleepiness were the most common complaints. OSA was prevalent in male patients, and most with OSA were not obese. Architectural distortion from the malignancy and/or treatment may predispose these patients to OSA by altering anatomic and neural factors. A heightened clinical suspicion for sleep-related breathing disorder and referral to a sleep specialist would be beneficial for patients with these complaints., (©AlphaMed Press.)
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- 2014
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26. Scrotal oedema in a man who had cystoprostatectomy and ileal diversion 9 years ago.
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Chen HK, Sinagra D, and Vivian J
- Subjects
- Aged, 80 and over, Cystectomy adverse effects, Humans, Male, Prostatectomy adverse effects, Urinary Bladder Neoplasms surgery, Edema etiology, Genital Diseases, Male etiology, Neoplasms, Squamous Cell complications, Penile Neoplasms complications, Scrotum
- Published
- 2014
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27. HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis.
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Carreira H, Coutinho F, Carrilho C, and Lunet N
- Subjects
- Eye Neoplasms complications, Eye Neoplasms virology, Female, HIV Infections complications, HIV Infections virology, Human papillomavirus 16, Human papillomavirus 18, Humans, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell virology, Papillomavirus Infections complications, Papillomavirus Infections virology, Prevalence, Risk Factors, Eye Neoplasms epidemiology, HIV Infections epidemiology, Neoplasms, Squamous Cell epidemiology, Papillomavirus Infections epidemiology
- Abstract
Background: The frequency of ocular surface squamous neoplasias (OSSNs) has been increasing in populations with a high prevalence of infection with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and infection with human papillomavirus (HPV). We aimed to quantify the association between HIV/AIDS and HPV infection and OSSN, through systematic review and meta-analysis., Methods: The articles providing data on the association between HIV/AIDS and/or HPV infection and OSSN were identified in MEDLINE, SCOPUS and EMBASE searched up to May 2013, and through backward citation tracking. The DerSimonian and Laird method was used to compute summary relative risk (RR) estimates and 95% confidence intervals (95% CI). Heterogeneity was quantified with the I(2) statistic., Results: HIV/AIDS was strongly associated with an increased risk of OSSN (summary RR=8.06, 95% CI: 5.29-12.30, I(2)=56.0%, 12 studies). The summary RR estimate for the infection with mucosal HPV subtypes was 3.13 (95% CI: 1.72-5.71, I(2)=45.6%, 16 studies). Four studies addressed the association between both cutaneous and mucosal HPV subtypes and OSSN; the summary RR estimates were 3.52 (95% CI: 1.23-10.08, I(2)=21.8%) and 1.08 (95% CI: 0.57-2.05, I(2)=0.0%), respectively., Conclusion: Human immunodeficiency virus infection increases the risk of OSSN by nearly eight-fold. Regarding HPV infection, only the cutaneous subtypes seem to be a risk factor.
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- 2013
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28. Coexistence of adamantinomatous and squamous-papillary type craniopharyngioma: case report and discussion of etiology and pathology.
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Okada T, Fujitsu K, Ichikawa T, Mukaihara S, Miyahara K, Kaku S, Uryuu Y, Niino H, Yagishita S, and Shiina T
- Subjects
- Aged, 80 and over, Craniopharyngioma complications, Humans, Male, Neoplasms, Squamous Cell complications, Pituitary Neoplasms complications, Craniopharyngioma etiology, Craniopharyngioma pathology, Neoplasms, Squamous Cell etiology, Neoplasms, Squamous Cell pathology, Pituitary Neoplasms etiology, Pituitary Neoplasms pathology
- Abstract
Craniopharyngiomas are histopathologically classified as adamantinomatous type (AD) and squamous-papillary type (SP). However coexistence of a mixed type seen on histopathologic specimens has not been reported. In this report, a patient diagnosed with mixed type craniopharyngioma is presented and the etiology and pathologic features are discussed., (© 2011 Japanese Society of Neuropathology.)
- Published
- 2012
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29. Transduodenal endosonography-guided biliary drainage and duodenal stenting for palliation of malignant obstructive jaundice and duodenal obstruction.
- Author
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Maluf-Filho F, Retes FA, Neves CZ, Sato CF, Kawaguti FS, Jureidini R, Ribeiro U Jr, and Bacchella T
- Subjects
- Adenocarcinoma complications, Aged, Aged, 80 and over, Biliary Tract diagnostic imaging, Drainage methods, Duodenum diagnostic imaging, Female, Humans, Intestinal Obstruction diagnostic imaging, Intestinal Obstruction etiology, Jaundice, Obstructive diagnostic imaging, Jaundice, Obstructive etiology, Male, Middle Aged, Neoplasms, Squamous Cell complications, Pancreatic Neoplasms complications, Retrospective Studies, Treatment Outcome, Uterine Cervical Neoplasms complications, Cholangiopancreatography, Endoscopic Retrograde methods, Intestinal Obstruction surgery, Jaundice, Obstructive surgery, Palliative Care methods, Stents
- Abstract
Context: Endosonography-guided biliary drainage has been used over the last few years as a salvage procedure when endoscopic retrograde cholangiopancreatography fails. Malignant gastric outlet obstruction may also be present in these patients. We report the results of both procedures during the same session in patients with duodenal and biliary obstruction due to malignant disease., Methods: A retrospective review from a prospective collected database., Results: Technical success was achieved in all five patients; however, only three patients experienced relief of jaundice and gastric outlet obstruction., Conclusions: Endosonography-guided biliary drainage and duodenal stenting in the same session is feasible. However, severe complications may limit the procedure. This is a challenging procedure and should be done by experts with special attention to patient's selection.
- Published
- 2012
30. Vasodepressor syncope and recurrent pharyngeal carcinoma: a form of carotid sinus syndrome?
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Luckie M and Brack MJ
- Subjects
- Blood Pressure, Carotid Artery Diseases diagnosis, Diagnosis, Differential, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Syncope, Vasovagal diagnosis, Syndrome, Carotid Artery Diseases etiology, Carotid Sinus, Neoplasms, Squamous Cell complications, Pharyngeal Neoplasms complications, Syncope, Vasovagal etiology
- Abstract
Syncope occurring in the setting of head and neck malignancy may have several possible causes. Local effects of a tumour in the parapharyngeal area may produce a syncopal syndrome similar to carotid sinus hypersensitivity, but with distinctive differentiating features. This article presents a case of profound vasodepressor syncope in a patient with recurrent pharyngeal malignancy, and discusses the mechanisms by which this occurs and the possible therapeutic options.
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- 2011
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31. Management and outcome of head and neck squamous cell carcinomas in obese patients.
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Deneuve S, Tan HK, Eghiaian A, and Temam S
- Subjects
- Adult, Aged, Alcohol Drinking adverse effects, Carcinoma mortality, Carcinoma therapy, Carcinoma, Squamous Cell, Female, Head and Neck Neoplasms mortality, Head and Neck Neoplasms therapy, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasms, Squamous Cell mortality, Neoplasms, Squamous Cell therapy, Obesity therapy, Prognosis, Retrospective Studies, Risk Factors, Squamous Cell Carcinoma of Head and Neck, Treatment Outcome, Carcinoma complications, Head and Neck Neoplasms complications, Neoplasms, Squamous Cell complications, Obesity complications, Smoking adverse effects
- Abstract
Head and neck squamous cell carcinomas are common lesions, related to chronic smoking and drinking behaviors. But in contrast to other cancers, effect of obesity on occurrence, diagnosis, treatment and prognosis of these tumors remains to date unknown. This is a retrospective review of 111 obese patients (sex ratio=6.4, median age=54.5 year old), treated between 1999 and 2007. Risk factors, tumoral localization and staging (41% stage I-II) were the same as in general population. However, we found 26.1% difficult pan-endoscopies, 54% ACE-27 comorbidity scores ≥2 and 22.5% misstaged cervical lymphadenopathy. Treatment was based upon surgery (61%) or radiotherapy-chemotherapy (39%), and 37% of patients developed complications. Median follow up (38 months) and five-year overall survival (50%) are comparable to data in non obese patients. Although no direct relation between obesity and squamous cell carcinomas of the head and neck was found, obesity causes problems in tumor assessment and increases surgical complications rate. However, final good therapeutic tolerance and overall survival rate show that these patients should be managed like normal weighted ones. Receiving optimal treatments allow them to anticipate equivalent outcome as in general population., (Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2011
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32. Distress, quality of life, neuroticism and psychological coping are related in head and neck cancer patients during follow-up.
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Aarstad AK, Beisland E, Osthus AA, and Aarstad HJ
- Subjects
- Adult, Aged, Carcinoma complications, Carcinoma epidemiology, Carcinoma psychology, Carcinoma, Squamous Cell, Cohort Studies, Female, Follow-Up Studies, Head and Neck Neoplasms complications, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms psychology, Humans, Male, Middle Aged, Models, Biological, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell epidemiology, Neoplasms, Squamous Cell psychology, Research Design, Squamous Cell Carcinoma of Head and Neck, Adaptation, Psychological physiology, Anxiety Disorders epidemiology, Quality of Life psychology, Stress, Psychological epidemiology
- Abstract
Unlabelled: The aim of the present study was to study the relation between distress, quality of life (QoL), personality and choice of coping in successfully treated head and neck squamous cell carcinoma (HNSCC) patients, and to study whether distress could be regarded as a QoL variable., Material and Methods: We determined present distress by the general health questionnaire (GHQ), QoL by the European Organization for Research and Treatment of Cancer Quality of life Questionnaire (EORTC-QLQ) C30/H&N35, personality by the Eysenck Personality Inventory and coping by the COPE questionnaire. All patients younger than 80 years who had been diagnosed with HNSCC in Western Norway in the period from 1992 to October 2001, and who had survived at least 12 months without evidence of disease were interviewed. In addition, treatment level, TNM stage, alcohol consumption level as well as smoking level were determined. One hundred and thirty-nine patients (96.5% response rate) were included., Results: Distress and QoL indexes were scored with a common variance (CV) between 20% and 35%. The measured variables account for 40-48% of the variance of the QoL/GHQ scores. Between 3% and 10% of the GHQ/general QoL scores and 10% of the variance of the H&N35 QoL scores were predicted by the TNM stage. The measured psychological factors accounted for 20% of the H&N35 QoL scores and 40% of the measured variance of the general QoL and GHQ responses. High neuroticism (CV≈20-35%), present avoidance coping (CV≈10-30%) and coping by suppression of competing activity (CV≈10-20%) were associated with low QoL and high distress., Conclusion: GHQ and QoL scores are scored similar, and are to some extent predicted by treatment related factors, but between 2.5 and 10 times more closely associated with psychological factors. Distress may possibly also be regarded as a QoL variable.
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- 2011
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33. Enteral feeding during chemoradiotherapy for advanced head-and-neck cancer: a single-institution experience using a reactive approach.
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Clavel S, Fortin B, Després P, Donath D, Soulières D, Khaouam N, Charpentier D, Bélair M, Guertin L, and Nguyen-Tan PF
- Subjects
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carboplatin administration & dosage, Carcinoma complications, Carcinoma drug therapy, Carcinoma pathology, Carcinoma radiotherapy, Carcinoma, Squamous Cell, Combined Modality Therapy methods, Disease-Free Survival, Female, Fluorouracil administration & dosage, Follow-Up Studies, Head and Neck Neoplasms complications, Head and Neck Neoplasms pathology, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Mucositis, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell drug therapy, Neoplasms, Squamous Cell pathology, Neoplasms, Squamous Cell radiotherapy, Patient Care Team, Radiodermatitis etiology, Radiotherapy Dosage, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck, Stomatitis etiology, Weight Loss, Enteral Nutrition methods, Head and Neck Neoplasms drug therapy, Head and Neck Neoplasms radiotherapy, Malnutrition therapy
- Abstract
Purpose: The optimal method for providing enteral nutrition to patients with head-and-neck cancer is unclear. The purpose of the present study was to evaluate the safety and efficacy of our reactive policy, which consists of the installation of a nasogastric (NG) feeding tube only when required by the patient's nutritional status., Methods and Materials: The records of all patients with Stage III and IV head-and-neck cancer treated with concomitant chemotherapy and radiotherapy between January 2003 and December 2006 were reviewed. The overall and disease-free survival rates were estimated using the Kaplan-Meier method and compared with the log-rank test., Results: The present study included 253 patients, and the median follow-up was 33 months. At 3 years, the estimated overall survival and disease-free survival rate was 82.8% and 77.8%, respectively, for the whole population. No survival difference was observed when the patients were compared according to the presence and absence of a NG tube or stratified by weight loss quartile. The mean weight loss during treatment for all patients was 10.4%. The proportion of patients requiring a NG tube was 49.8%, and the NG tube remained in place for a median duration of 40 days. No major complications were associated with NG tube installation. Only 3% of the patients were still dependent on enteral feeding at 6 months., Conclusion: These results suggest that the use of a reactive NG tube with an interdisciplinary team approach is a safe and effective method to manage malnutrition in patients treated with concomitant chemotherapy and radiotherapy for head-and-neck cancer., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
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34. Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line.
- Author
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Harris M, Wang XG, Jiang Z, Goldberg GL, Casadevall A, and Dadachova E
- Subjects
- Animals, Carcinoma complications, Carcinoma immunology, Carcinoma radiotherapy, Carcinoma virology, Carcinoma, Squamous Cell, Cell Line, Tumor, Head and Neck Neoplasms complications, Head and Neck Neoplasms immunology, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms virology, Humans, Mice, Mice, Nude, Models, Biological, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell immunology, Neoplasms, Squamous Cell radiotherapy, Neoplasms, Squamous Cell virology, Papillomavirus Infections complications, Papillomavirus Infections immunology, Squamous Cell Carcinoma of Head and Neck, Xenograft Model Antitumor Assays, Antibodies, Viral therapeutic use, Human papillomavirus 16 immunology, Oncogene Proteins, Viral immunology, Papillomavirus Infections radiotherapy, Radioimmunotherapy methods, Repressor Proteins immunology
- Abstract
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide with a poor prognosis. Human papilloma virus (HPV) infection is associated with 20% HNSCC, and 50% of oropharyngeal carcinoma. HPV16 type is detected in 90% of all HPV+ HNSCC. Recently we suggested a fundamentally different approach to treatment of cancers of viral origin by targeting viral antigens on cancer cells with radiolabeled antibodies (mAbs) which promises exquisite specificity of treatment. We aimed at extending this approach to HPV-related head and neck cancer by performing radioimmunotherapy (RIT) targeting E6 and E7 oncogenes with radiolabeled mAbs., Methods: We first aimed at developing HPV16+ cell line and animal model for RIT of HNSCC as at present there are no commercially available HPV16+ HNSCC cell lines and there is only one HPV+ cell line among the collection maintained by Dusseldorf, Michigan and Turku groups. Commercially available HNSCC cell line FaDu was transfected with pLXSN16E6E7 vector containing HPV16 E6 and E7 genes. Generated novel cell lines were evaluated by PCR and western blot and the tumorigenecity was assessed in nude mice. Proof of principle RIT targeting E6 oncoprotein in 2A3 tumor-bearing nude mice was conducted using unlabeled or 188-Rhenium (188Re)-labeled C1P5 mAb to E6., Results: Novel HPV16+ 2A3 cell line reliably expressed E6 oncoprotein. E6 expression was modifiable with proteasome inhibitor MG132 in a dose-dependent manner. The levels of E6 expression in 2A3 cell line were estimated to be around 200 HPV copies per cell. The HPV16+ 2A3 cell line preserved 100% tumorigenicity of parent FaDu cells in nude mice. During RIT of 2A3 tumors in nude mice the relatively low dose of 200 μCi 188Re-C1P5 mAb was effective in decreasing the tumor growth in comparison with untreated controls. Unlabeled C1P5 mAb also caused some decrease in tumor progression, however, much less pronounced than 188Re-C1P5 mAb., Conclusions: We describe a proof-of-principle RIT study targeting HPV16 E6 oncoprotein with radiolabeled mAb to E6 in a stably transformed HPV16+ HNSCC cell line and tumor model in nude mice, and demonstrate potential utility of RIT as a novel molecular targeted therapy for HNSCC.
- Published
- 2011
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35. Squamous cell carcinoma arising from human papillomavirus associated cyst.
- Author
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Pusiol T, Piscioli F, and Zorzi MG
- Subjects
- Aged, 80 and over, Epidermal Cyst complications, Epidermal Cyst pathology, Female, Humans, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell pathology, Papillomavirus Infections pathology, Skin Neoplasms complications, Skin Neoplasms pathology, Epidermal Cyst virology, Neoplasms, Squamous Cell virology, Papillomavirus Infections complications, Skin Neoplasms virology
- Published
- 2011
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36. The role of human papillomavirus infection in head and neck cancers.
- Author
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Syrjänen S
- Subjects
- Carcinoma complications, Carcinoma epidemiology, Carcinoma prevention & control, Carcinoma virology, Carcinoma, Squamous Cell, DNA, Viral isolation & purification, Genetic Testing, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms prevention & control, Head and Neck Neoplasms virology, Humans, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell epidemiology, Neoplasms, Squamous Cell prevention & control, Neoplasms, Squamous Cell virology, Oropharyngeal Neoplasms complications, Oropharyngeal Neoplasms epidemiology, Oropharyngeal Neoplasms virology, Papillomaviridae isolation & purification, Papillomavirus Infections diagnosis, Papillomavirus Infections epidemiology, Papillomavirus Infections therapy, Papillomavirus Vaccines therapeutic use, Prognosis, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms complications, Papillomaviridae physiology, Papillomavirus Infections complications
- Abstract
The link between head and neck squamous cell cancer (HNSCC), especially oropharyngeal cancer, and HPV has become established. HPV16 is the most common genotype in these tumours but HPV6 and HPV11 can also be found in a minority of these cancers, implying that these low-risk HPV types are not entirely benign in the head and neck region. HPV status is also associated with p16 expression and HPV+ tumours are less likely to harbour p53 mutations. HPV DNA is closely associated with poorly differentiated cancers, positive lymph nodes and late-stage disease, which all indicate poor prognosis. Contradictory to this, patients with HPV+ HNSCC seem to have significantly improved response to chemotherapy and radiotherapy as compared with HPV-negative tumours. Interestingly, the risk factors of HNSCC are the same as for HPV, including the number of sexual partners, younger age at first sexual intercourse, practice of oral sex, history of genital warts and younger age.
- Published
- 2010
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37. Human leukocyte antigen-G (HLA-G) expression in cervical lesions: association with cancer progression, HPV 16/18 infection, and host immune response.
- Author
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Dong DD, Yang H, Li K, Xu G, Song LH, Fan XL, Jiang XL, and Yie SM
- Subjects
- Adult, Aged, Aged, 80 and over, Disease Progression, Female, HLA-G Antigens, Humans, Immunity, Cellular, Lymphocytes, Tumor-Infiltrating metabolism, Middle Aged, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell immunology, Neoplasms, Squamous Cell metabolism, Neoplasms, Squamous Cell pathology, Papillomavirus Infections complications, Papillomavirus Infections virology, Uterine Cervical Neoplasms complications, Uterine Cervical Neoplasms pathology, Young Adult, Uterine Cervical Dysplasia complications, Uterine Cervical Dysplasia immunology, Uterine Cervical Dysplasia metabolism, Uterine Cervical Dysplasia pathology, HLA Antigens metabolism, Histocompatibility Antigens Class I metabolism, Human papillomavirus 16 isolation & purification, Human papillomavirus 18 isolation & purification, Papillomavirus Infections metabolism, Uterine Cervical Neoplasms immunology, Uterine Cervical Neoplasms metabolism
- Abstract
Human leukocyte antigen-G (HLA-G) expression in 55 cervical intraepithelial neoplasia (CIN) patients with or without human papillomavirus (HPV) infection and 116 patients with squamous cell cervical cancer were examined using immunohistochemistry. Host immune response was assessed by estimating the number of intratumoral lymphocyte infiltration (TIL) in all lesions and counting CD57-expressing cells in the neoplasm lesions. The means of HLA-G immunoreactive scores were compared by the Mann-Whitney test and 1-way analysis of variance (ANOVA). The association of HLA-G expression with disease progression, HPV infection and host immune response was calculated using the Pearson Chi-square test. It was found that HLA-G expression increasingly progressed from patients with CIN 1 to CIN 2/3 and was highest in patients with cervical cancer. Human leukocyte antigen-G expression was also significantly higher in CIN and cancer patients with HPV 16/18 than in CIN patients without HPV. A significant correlation between HLA-G expression and TIL score or the counting of CD57-expressing cells was also evident in CIN patients with HPV infection and cervical cancer cases. These results suggest that HLA-G expression in cervical lesions is associated with carcinogenesis, HPV infection, and host immune response.
- Published
- 2010
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38. Why do some lung cancer patients receive no anticancer treatment?
- Author
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Vinod SK, Sidhom MA, Gabriel GS, Lee MT, and Delaney GP
- Subjects
- Adenocarcinoma complications, Adenocarcinoma pathology, Aged, Aged, 80 and over, Australia, Carcinoma, Large Cell complications, Carcinoma, Large Cell pathology, Carcinoma, Non-Small-Cell Lung complications, Carcinoma, Non-Small-Cell Lung pathology, Comorbidity, Decision Making, Female, Humans, Ireland, Lung Neoplasms complications, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell pathology, Patient Preference, Prospective Studies, Scotland, Small Cell Lung Carcinoma complications, Small Cell Lung Carcinoma pathology, Survival Rate, Treatment Outcome, United States, Adenocarcinoma therapy, Carcinoma, Large Cell therapy, Carcinoma, Non-Small-Cell Lung therapy, Lung Neoplasms therapy, Neoplasms, Squamous Cell therapy, Small Cell Lung Carcinoma therapy
- Abstract
Introduction: A significant proportion of lung cancer patients receive no anticancer treatment. This varies from 19% in USA, 33% in Australia, 37% in Scotland, and 50% in Ireland. The aim of this study was to identify the reasons behind this., Methods: The Lung Cancer Multidisciplinary Meeting (MDM) in South-West Sydney prospectively collects data on all patients presented. All new lung cancer patients presented between December 1, 2005, and December 31, 2007, were reviewed. Patients were assigned optimal treatment based on evidence-based guidelines. Those patients in whom guidelines recommended no treatment (GNT) were compared with those whom the MDM recommended no treatment (MNT) and with those who actually received no treatment (ANT)., Results: There were 335 patients with a median age of 69 years. A total of 82% had non-small cell lung cancer, 14% had small cell lung cancer, and 4% had no pathologic diagnosis. Eighty-five percent had locally advanced or metastatic disease. GNT was recommended in 4% (n = 13), MNT in 10% (n = 32) but ANT comprised 20% (n = 66). The differences between GNT and MNT were mainly due to patient comorbidities and clinician decision, but the differences between MNT and ANT were due to patient preference and declining performance status. In multivariate analysis, older age, poorer Eastern Cooperative Oncology Group status, non-small cell lung cancer, and non-English language predicted for ANT., Conclusions: The proportion of patients with lung cancer receiving no treatment is greater than that predicted by guidelines or recommended by the MDM but lower than that described in population-based studies suggesting that MDMs can improve treatment utilization in lung cancer.
- Published
- 2010
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39. Cetuximab in the treatment of rheumatoid arthritis.
- Author
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Sullivan T, Benjamin CG, Kempf PW, and Deeken JF
- Subjects
- Antibodies, Monoclonal, Humanized, Antineoplastic Agents therapeutic use, Arthritis, Rheumatoid complications, Cetuximab, Female, Humans, Middle Aged, Neoplasms, Squamous Cell complications, Remission Induction, Tongue Neoplasms complications, Antibodies, Monoclonal therapeutic use, Arthritis, Rheumatoid drug therapy, ErbB Receptors antagonists & inhibitors, Neoplasms, Squamous Cell drug therapy, Tongue Neoplasms drug therapy
- Abstract
Members of the epidermal growth factor receptor (EGFR) family and their associated ligands are commonly expressed by synovial cells, and may be involved in the synovial hyperplasia seen in rheumatoid arthritis and its disease progression. This family of receptors is also expressed in cancer cells, and EGFR targeted therapy is now a mainstay of anticancer therapy. Cetuximab (Erbitux) is a monoclonal antibody directed against the EGFR extracellular receptor that has received Food and Drug Administration approval for the treatment of colorectal cancer as well as head and neck cancer. We report a case of a 61-year-old woman with an extensive history of rheumatoid arthritis requiring multiple therapies, who experienced a surprising remission of her disease and its symptoms while being treated with cetuximab for her head and neck cancer. The case as well as possible mechanisms of action are discussed. Further clinical investigations are clearly warranted.
- Published
- 2010
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40. A rare cause of small bowel transection: metastatic lung cancer.
- Author
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Yildirim M, Tasli F, Bayam ME, and Postaci H
- Subjects
- Aged, Humans, Ileal Neoplasms secondary, Male, Neoplasms, Squamous Cell secondary, Ileal Neoplasms complications, Intestinal Perforation etiology, Lung Neoplasms pathology, Neoplasms, Squamous Cell complications
- Abstract
Objective: To present a case of small bowel perforation due to metastatic lung cancer., Case Presentation and Intervention: A 78-year-old male patient, who had been diagnosed with lung cancer 3 months earlier, presented to our clinic with acute abdominal pain. He underwent emergency laparotomy. At surgery, there was a circumferential lesion encompassing the ileum with complete transection. There was no obvious macroscopic appearance of metastatic disease. The involved bowel segment was resected and an ileostomy was performed. Postoperative pathologic analysis confirmed metastatic squamous cell carcinoma metastasis to the ileum, arising from the patient's lung cancer., Conclusion: This case report showed that small bowel metastases should always be considered in the differential diagnosis of lung cancer patients presenting with acute abdominal pain., (Copyright (c) 2010 S. Karger AG, Basel.)
- Published
- 2010
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41. Lower-limb lymphedema and vulval cancer: feasibility of prophylactic compression garments and validation of leg volume measurement.
- Author
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Sawan S, Mugnai R, Lopes Ade B, Hughes A, and Edmondson RJ
- Subjects
- Adult, Aged, Aged, 80 and over, Feasibility Studies, Female, Humans, Lower Extremity pathology, Lymphedema etiology, Middle Aged, Neoplasms, Squamous Cell complications, Organ Size, Physical Examination methods, Preventive Medicine methods, Vulvar Neoplasms complications, Body Weights and Measures methods, Leg pathology, Lymphedema prevention & control, Neoplasms, Squamous Cell therapy, Stockings, Compression, Vulvar Neoplasms therapy
- Abstract
Objectives: Leg lymphedema remains a significant health problem after treatment of vulval cancer. This pilot study explored the feasibility of conducting a larger trial to investigate whether the early use of compression stockings is effective in preventing leg lymphedema., Methods: Fourteen patients undergoing inguinofemoral lymphadenectomy for vulval cancer were randomized to either best supportive care or best supportive care plus the use of graduated compression stockings for 6 months., Results: Six of 7 patients in the treatment group complied with the study protocol. The incidence of clinically significant lymphedema was not different between both groups; however, there was a greater increase in mean leg volume in the control group (953 vs 607 mL, P = 0.010). Furthermore, patients in the treatment group showed better performance as judged by leg symptoms (P = 0.031, at 3 months) and clinical examination (P = 0.039 at 4 weeks and P = 0.004 at 6 months). There was no difference in the incidence of groin wound dehiscence, infection, or lymphocyst formation. We detected no difference between both groups' scores when using a validated quality-of-life questionnaire. Intraobserver and interobserver variabilities of leg-volume measurement technique were investigated using the principles of repeatability and reproducibility statistics. Intraobserver variability was estimated at 270 mL, whereas interobserver variability was 1000 mL., Conclusions: The prophylactic use of stockings in this population is feasible, and further larger studies are justified to investigate its role in reducing the incidence of leg lymphedema. The design of these studies should take into account the observer-related variability in measuring leg volume or consider alternative methods.
- Published
- 2009
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42. Prevalence and severity of cervical squamous intraepithelial lesion in a tertiary hospital in northern Tanzania.
- Author
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Obure J, Olola O, Swai B, Mlay P, Masenga G, and Walmer D
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, CD4 Lymphocyte Count, Cross-Sectional Studies, Female, HIV Infections complications, HIV Infections immunology, Hospitals, Teaching, Humans, Middle Aged, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell pathology, Pregnancy, Prevalence, Prospective Studies, Risk Factors, Severity of Illness Index, Tanzania epidemiology, Uterine Cervical Neoplasms pathology, Vaginal Smears, Young Adult, Uterine Cervical Dysplasia complications, Uterine Cervical Dysplasia pathology, HIV Infections epidemiology, Neoplasms, Squamous Cell epidemiology, Uterine Cervical Neoplasms epidemiology, Uterine Cervical Dysplasia epidemiology
- Abstract
Cervical cancer is the second most common cancer in women worldwide and the leading cause of cancer deaths in Tanzanian women. Prevention of cervical cancer relies on the detection and treatment of Squamous Intraepithelial Lesion (SIL), a premalignant disease stage. Worldwide there are overwhelming reports associating SIL and HIV infection, however in Tanzania such reports are limited. A cross-sectional hospital-based descriptive study was conducted to determine the prevalence and severity of SIL in 234 HIV seropositive and seronegative women aged 18-68 years old at Kilimanjaro Christian Medical Centre in northern Tanzania. A structured questionnaire was used to collect sociodemographic data. In addition, blood was collected for rapid HIV antibody testing and CD4+ T-lymphocyte counts to associate with prevalence and severity of SIL from the cervical smear collections. A total of 214 subjects had smear results regarded as valid for interpretation, of which 46.3% were HIV seropositive. Overall rate of SIL was 17%. Proportion of SIL among HIV seropositive subjects was 32% versus 4% in seronegative subjects (OR = 13.3, 95% CI = 4.2-46.4). Low CD4+ T-lymphocyte cell count was associated with higher prevalence of SIL (P = 0.001). The relationship between CD4+ T-lymphocyte cell counts and the severity of cervical SIL was significant (P = 0.007). Marital status and number of lifetime sex partners were risk factors significantly associated with SIL (P = 0.004 and 0.005, respectively). SIL was not associated with age, education level, parity or age at sex debut. The prevalence and severity of cervical SIL was significantly associated with HIV infection and immunologic disease progression. These findings underscore the need for HIV screening among women with SIL, and the need for cervical cancer screening in HIV-infected women. Marital status and number of lifetime sex partners were significant risk factors associated with SIL.
- Published
- 2009
- Full Text
- View/download PDF
43. HPV genotypes in women with squamous intraepithelial lesions and normal cervixes participating in a community-based microbicide study in Pretoria, South Africa.
- Author
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Said HM, Ahmed K, Burnett R, Allan BR, Williamson AL, and Hoosen AA
- Subjects
- Anti-Infective Agents therapeutic use, Female, Genotype, Humans, Papillomaviridae genetics, Polymerase Chain Reaction methods, Prevalence, South Africa epidemiology, Cervix Uteri virology, Neoplasms, Squamous Cell complications, Papillomaviridae classification, Papillomaviridae isolation & purification, Papillomavirus Infections epidemiology, Papillomavirus Infections virology
- Abstract
Background: Little is known regarding the human papillomaviruses (HPV) genotypes prevalent in women in South Africa, a country with a high incidence of cervical cancer., Objective: To determine the prevalence and HPV genotypes in women with squamous abnormalities and normal cervixes participating in a community-based microbicide study., Study Design: A total of 159 cervical specimens, including 56 specimens from women with abnormal cytology (cases) and 103 randomly selected specimens from women with normal cytology (controls), were collected. HPV was detected by consensus PCR primers and HPV genotypes were determined by Roche Linear Array HPV genotyping assay., Results: HPV genotypes were found in 91% of cases and 40% of controls (p<0.005). High-risk HPV was detected in all high-grade squamous intraepithelial lesions (HSILs), 69% of low-grade squamous intraepithelial lesions (LSILs), 57% of atypical squamous cells of undetermined significance (ASCUS), and 86% of ASCUS in which HSIL could not be excluded (ASCUS-H), and 73% of HPV positive controls. HPV-35 was the predominant genotype in HSILs; HPV-18 in ASCUS; HPV-58 in ASCUS-H and HPV-16 in LSILs and controls., Conclusion: High-risk HPV prevalence was high in both cases and controls. HPV genotype distribution in HSILs was different from that reported worldwide and from other studies in South Africa.
- Published
- 2009
- Full Text
- View/download PDF
44. Free radial forearm flap lip reconstruction: a clinical series and case reports of technical refinements.
- Author
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Daya M and Nair V
- Subjects
- Adolescent, Adult, Aged, Humans, Lip Neoplasms complications, Lip Neoplasms surgery, Male, Middle Aged, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell surgery, Noma complications, Oral Surgical Procedures, Treatment Outcome, Wounds and Injuries etiology, Young Adult, Forearm surgery, Lip surgery, Plastic Surgery Procedures methods, Surgical Flaps, Wounds and Injuries surgery
- Abstract
Lip reconstruction is best suited to the dictum of replacement of like tissue with like. The use of the remaining lip in the use of the lip reconstruction becomes more difficult as the size of the defect increases. The use of local tissue for subtotal lower lip loss problems like microstomia and facial and commissure distortion are real risks. The use of free tissue transfer becomes especially an attractive option when in addition to the lip there is associated loss of other aesthetic units and/or mandibular bone loss. The potential value of local perioral tissue is more likely to maintain dynamic and sensory function of the lip.Five patients were included in the clinical series during a period of 3 1/2 years since January 2002. All 5 patients were men. The age ranged from 15 to 67 years. Four patients underwent reconstruction by composite radial forearm flaps including both the cutaneous nerve of the forearm and the palmaris longus tendon. A single patient in this group had a partial brachioradialis muscle flap raised as chimeric component to the composite radial forearm flap. In the fifth patient, 2 simultaneous free radial forearm flaps were used for both upper and lower lip and bilateral buccal mucosal reconstruction. All patients achieved the goals of providing an adequate mouth opening with competence. The refinement of dynamic palmaris sling attachment to the perioral muscle provided for very good oral competence and support. In the single patient, adding bulk with the brachioradialis muscle to the neo lower lip most likely served to improve both aesthetics and lip function. With the use of free flaps an adequate labial sulcus, near dynamic sphincter control and sensation can be restored. The major drawback, however, is aesthetics of the lip. Further refinements like vermillion tattooing, fat injections or defatting by liposuction, and secondary mucosal flap surgery to provide the neolip with a vermillion are beneficial.
- Published
- 2009
- Full Text
- View/download PDF
45. Invader human papillomavirus (HPV) type 16 and 18 assays as adjuncts to HPV screening of cervical papanicolaou smears with atypical squamous cells of undetermined significance.
- Author
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Wong AK, Chan RC, Nichols WS, and Bose S
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, DNA, Viral analysis, Female, Follow-Up Studies, Humans, Mass Screening methods, Middle Aged, Neoplasm Staging, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell virology, Papillomaviridae genetics, Papillomavirus Infections virology, Retrospective Studies, Uterine Cervical Neoplasms virology, Young Adult, Uterine Cervical Dysplasia diagnosis, Uterine Cervical Dysplasia virology, Human papillomavirus 16 isolation & purification, Human papillomavirus 18 isolation & purification, Neoplasms, Squamous Cell diagnosis, Papanicolaou Test, Papillomavirus Infections diagnosis, Uterine Cervical Neoplasms diagnosis, Vaginal Smears
- Abstract
Background: High-risk (HR) human papillomavirus (HPV) testing is standard practice for triaging women who have Papanicolaou (Pap) smears with atypical squamous cells of undetermined significance (ASC-US), however, only 5% to 17% of these women have underlying cervical intraepithelial neoplasia 2 (CIN-2)/CIN-3. Recent reports have demonstrated that the presence of either HPV type 16 (HPV-16) or HPV-18 confers an elevated risk for CIN-2/CIN-3. The current study was designed to determine the prevalence of HPV-16 and HPV-18 in ASC-US Pap smears and to determine whether further typing would enhance the risk stratification of patients for CIN-2/CIN-3., Methods: One hundred seventy-eight Pap smears with ASC-US were screened retrospectively for HR HPV by using the proprietary Invader screening assay followed by typing for HPV-16 and HPV-18 by using Invader type-specific probes on 100 of the samples. Clinical follow-up results were correlated with HPV types., Results: Fifty-one percent of the ASC-US samples were positive for HR HPV, the majority of which (70%) harbored non-HPV-16/HPV-18 HR HPV types; 27% were associated with HPV-16, whereas only 3% contained HPV-18. The screening assay indicated that 46% of women who had Pap smears with ASC-US were in need of further HPV-16/HPV-18 typing. Testing for HPV-16 stratified women with ASC-US into 3 groups: 1) 14% of women were positive for HPV-16 and had a high risk (54%) of CIN-2/CIN-3 on follow-up biopsy, 2) 35% of women were positive for non-HPV-16 HPV types and had an intermediate risk (9%), and 3) 51% of women were negative for HPV and had a negligible risk for CIN-2/CIN-3., Conclusions: The combined application of a proprietary screening assay and a type-specific HPV-16 assay demonstrated global potential for the development of tailored management protocols for women who have Pap smears with ASC-US., ((c) 2009 American Cancer Society.)
- Published
- 2009
- Full Text
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46. Acquired factor V inhibitor in a patient with gingival squamous cell cancer and tuberculosis.
- Author
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Chenthilmurugan R, Kodali S, Chenthilmurugan H, Steier W, Schwartz J, and Kalavar M
- Subjects
- Aged, Fatal Outcome, Humans, Male, Neoplasms, Squamous Cell complications, Factor V antagonists & inhibitors, Neoplasms, Squamous Cell blood, Tuberculosis blood, Tuberculosis complications
- Published
- 2008
47. Eccrine syringofibroadenoma associated with well-differentiated squamous cell carcinoma.
- Author
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Kacerovska D, Nemcova J, Michal M, and Kazakov DV
- Subjects
- Aged, 80 and over, Fibroadenoma diagnosis, Fibroadenoma pathology, Hand, Humans, Male, Neoplasms, Squamous Cell diagnosis, Neoplasms, Squamous Cell pathology, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Syringoma diagnosis, Syringoma pathology, Fibroadenoma complications, Neoplasms, Squamous Cell complications, Skin Neoplasms complications, Sweat Gland Neoplasms complications, Syringoma complications
- Abstract
We report a case of an eccrine syringofibroadenoma (ESFA) associated with well-differentiated squamous cell carcinoma. The patient was an 85-year-old man, who had a 2.5x2.5-cm, brown-colored ulcerated nodule, with a fragile, flesh-colored bleeding surface located beyond the metacarpophalangeal joint of the second finger of his left hand. Histopathologically, there were areas of a well-differentiated squamous cell carcinoma, alternating with the typical area of ESFA characterized by anastomosing cords, strands, and columns of epithelial cells extending from the crusted epidermis into a thickened, edematous, myxoid vascular-rich dermis. Immunohistochemically, the areas with dysplastic epithelium were positive for p16, whereas the benign ESFA parts tested negative. Human papillomavirus was detected in the lesional tissue by polymerase chain reaction, and the subsequent sequencing analysis demonstrated that the virus was close to human papillomavirus type 107.
- Published
- 2008
- Full Text
- View/download PDF
48. Immunoglobulin A pemphigus associated with immunoglobulin A gammopathy and lung cancer.
- Author
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Petropoulou H, Politis G, Panagakis P, Hatziolou E, Aroni K, and Kontochristopoulos G
- Subjects
- Autoantibodies analysis, Fatal Outcome, Fluorescent Antibody Technique, Direct, Humans, Lung diagnostic imaging, Lung Neoplasms diagnostic imaging, Male, Middle Aged, Neoplasms, Squamous Cell diagnostic imaging, Paraproteinemias immunology, Pemphigus immunology, Pemphigus pathology, Skin pathology, Tomography, X-Ray Computed, Immunoglobulin A analysis, Lung Neoplasms complications, Neoplasms, Squamous Cell complications, Paraproteinemias complications, Pemphigus complications
- Abstract
Immunoglobulin (Ig)A pemphigus is a rare disease marked by a vesiculopustular eruption characterized by intercellular IgA deposition in the epidermis. It has clinical and histopathological heterogeneity and encompasses two subgroups: subcorneal pustular dermatosis type and intraepidermal neutrophilic IgA dermatosis type. IgA pemphigus has been rarely associated with monoclonal IgA paraprotein, myeloma and B-cell lymphoma in the past. We report the first case, to our knowledge, of a 47-year-old male patient with a subcorneal pustular dermatosis type of IgA pemphigus associated with IgA gammopathy and lung cancer.
- Published
- 2008
- Full Text
- View/download PDF
49. A case of Dirofilaria pulmonary infection coexisting with lung cancer.
- Author
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Mulanovich EA, Mulanovich VE, and Rolston KV
- Subjects
- Aged, Animals, Antineoplastic Agents therapeutic use, Diagnosis, Differential, Dogs, Humans, Lung parasitology, Lung pathology, Lung surgery, Lung Neoplasms diagnostic imaging, Lung Neoplasms drug therapy, Male, Neoplasms, Squamous Cell diagnostic imaging, Neoplasms, Squamous Cell drug therapy, Radiography, Dirofilaria immitis isolation & purification, Dirofilariasis complications, Lung Neoplasms complications, Neoplasms, Squamous Cell complications
- Abstract
Dirofilaria immitis, the dog heartworm, may accidentally infect humans and manifest as a subpleural solitary or multiple pulmonary nodules that are often difficult to differentiate from primary or metastatic lung tumors. Our patient had biopsy proven lung cancer and a second lesion found to be pulmonary dirofilariasis after excision. The coexistence of pulmonary infection and cancer must be considered whenever 2 or more lesions have different clinical and radiologic behavior. Pulmonary dirofilariasis is a rare cause of lung nodules and may be present with lung cancer even more infrequently.
- Published
- 2008
- Full Text
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50. Peripheral cannabinoids attenuate carcinoma-induced nociception in mice.
- Author
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Guerrero AV, Quang P, Dekker N, Jordan RC, and Schmidt BL
- Subjects
- Animals, Behavior, Animal drug effects, Disease Models, Animal, Female, Ganglia, Spinal metabolism, Humans, Mice, Mice, Nude, Pain pathology, Pain Measurement methods, Pain Threshold drug effects, Receptor, Cannabinoid, CB1 metabolism, Spinal Cord pathology, Time Factors, Benzoxazines therapeutic use, Cannabinoids therapeutic use, Carcinoma complications, Morpholines therapeutic use, Naphthalenes therapeutic use, Neoplasms, Squamous Cell complications, Pain drug therapy, Pain etiology
- Abstract
We investigated the cannabinoid receptor (CBr) agonists Win55,212-2 (non-selective) and AM1241 (CBr2 selective) and the peripheral receptor (CBr1) in carcinoma-induced pain using a mouse model. Tumors were induced in the hind paw of female mice by local injection of a human oral squamous cell carcinoma (SCC). Significant pain, as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, began at 4 days after SCC inoculation and lasted to 18 days. Local administration of Win55,212-2 (10 mg/kg) and AM1241 (10 mg/kg) significantly elevated withdrawal thresholds, indicating an antinociceptive effect. Ipsilateral expression of CBr1 protein in L5 DRG was significantly upregulated compared to ipsilateral L4 DRG and in normal tissue. These findings support the suggestion that cannabinoids are capable of producing antinociception in carcinoma-induced pain.
- Published
- 2008
- Full Text
- View/download PDF
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