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Administration of chemotherapy in patients on dialysis.
- Source :
-
Anti-cancer drugs [Anticancer Drugs] 2015 Aug; Vol. 26 (7), pp. 779-84. - Publication Year :
- 2015
-
Abstract
- The prevalence of patients on dialysis has increased and these patients present a challenge for chemotherapy administration when diagnosed with cancer. A consensus on the dosage and timing of different chemotherapeutic agents in relation to dialysis has not been established. We describe the pattern of care and treatment outcome for cancer patients on dialysis in our institution. The dataset from the Australia and New Zealand Dialysis and Transplant Registry of patients on dialysis who had a diagnosis of cancer was obtained and matched to the pharmacy records in our institution to identify patients who had received chemotherapy while on dialysis. Relevant clinical information including details of the dialysis regimen, chemotherapy administration and adverse events was extracted for analysis. Between July 1999 and July 2014, 21 patients on dialysis were included for analysis. Five (23.8%) received chemotherapy, most of which was administered before dialysis sessions. As a result of adverse events, one patient discontinued treatment; two other patients required dose reduction or treatment delay. Chemotherapy administration was feasible in cancer patients on dialysis, but chemotherapy usage was low. Better understanding of the altered pharmacokinetics in patients on dialysis may improve chemotherapy access and practice.
- Subjects :
- Aged
Carcinoma, Squamous Cell complications
Carcinoma, Squamous Cell drug therapy
Female
Humans
Kidney Failure, Chronic complications
Liver Neoplasms drug therapy
Liver Neoplasms secondary
Lung Neoplasms complications
Lung Neoplasms drug therapy
Male
Middle Aged
Neoplasms complications
Neoplasms, Germ Cell and Embryonal complications
Neoplasms, Germ Cell and Embryonal drug therapy
Neoplasms, Squamous Cell complications
Neoplasms, Squamous Cell drug therapy
Parotid Neoplasms complications
Parotid Neoplasms drug therapy
Parotid Neoplasms pathology
Skin Neoplasms complications
Skin Neoplasms drug therapy
Small Cell Lung Carcinoma complications
Small Cell Lung Carcinoma drug therapy
Testicular Neoplasms complications
Testicular Neoplasms drug therapy
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Kidney Failure, Chronic therapy
Neoplasms drug therapy
Renal Dialysis
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5741
- Volume :
- 26
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Anti-cancer drugs
- Publication Type :
- Academic Journal
- Accession number :
- 25933244
- Full Text :
- https://doi.org/10.1097/CAD.0000000000000243