1. Virological failure among people living with HIV receiving second-line antiretroviral therapy in Pune, India
- Author
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Sonali Salvi, Priyanka Raichur, Dileep Kadam, Shashikala Sangle, Nikhil Gupte, Neetal Nevrekar, Sandesh Patil, Amol Chavan, Smita Nimkar, Ivan Marbaniang, and Vidya Mave
- Subjects
HIV/AIDS ,Second-line antiretroviral ,Virological failure ,Adherence ,Protease inhibitors ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background The number of people receiving second-line antiretroviral therapy (ART) has increased as global access to ART has expanded. Data on the burden and factors associated with second-line ART virologic failure (VF) from India remain limited. Methods We conducted cross-sectional viral load (VL) testing among adults (≥ 18 years) who were registered at a publicly funded ART center in western India between 2014 and 2015 and had received second-line ART for at least 6 months. Sociodemographic and clinical characteristics were abstracted from routinely collected programmatic data. Logistic regression evaluated factors associated with VF (defined as VL > 1000 copies/mL). Results Among 400 participants, median age was 40 years (IQR 34–44), 71% (285/400) were male, and 15% (59/400) had VF. Relative to participants without VF, those with VF had lower median CD4 counts (230 vs 406 cells/mm3, p
- Published
- 2022
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