3,025 results on '"Nederlof, A."'
Search Results
2. Centrality dependence of L\'evy-stable two-pion Bose-Einstein correlations in $\sqrt{s_{_{NN}}}=200$ GeV Au$+$Au collisions
- Author
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PHENIX Collaboration, Abdulameer, N. J., Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bannier, B., Barish, K. N., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Castera, P., Chen, C. -H., Chen, D., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Corliss, R., Csanád, M., Csörgő, T., D'Orazio, L., Dairaku, S., Datta, A., Daugherity, M. S., David, G., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Doomra, V., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Guo, T., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Hashimoto, K., Haslum, E., Hayano, R., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Ichihara, T., Iinuma, H., Ikeda, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Issah, M., Ivanishchev, D., Jacak, B. V., Javani, M., Jiang, X., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kasza, G., Kawall, D., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. J., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kovacs, L., Krizek, F., Král, A., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Lim, S. H., Levy, L. A. Linden, Liu, M. X., Lökös, S., Loomis, D. A., Love, B., Maguire, C. F., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Mohapatra, S., Moon, H. J., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nihashi, M., Nouicer, R., Novák, T., Novitzky, N., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Okada, K., Orosz, M., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J. S., Park, S., Park, S. K., Patel, L., Pate, S. F., Pei, H., Peng, J. -C., Pereira, H., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Potekhin, M., Proissl, M., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Sahlmueller, B., Saito, N., Sakaguchi, T., Samsonov, V., Sano, M., Sarsour, M., Sawada, S., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sun, Z., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Themann, H., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Ujvari, B., Vale, C., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Vértesi, R., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., White, S. N., Winter, D., Wolin, S., Woody, C. L., Wysocki, M., Xia, B., Yamaguchi, Y. L., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Younus, I., You, Z., Yushmanov, I. E., Zajc, W. A., and Zelenski, A.
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Nuclear Experiment - Abstract
The PHENIX experiment measured the centrality dependence of two-pion Bose-Einstein correlation functions in $\sqrt{s_{_{NN}}}=200$~GeV Au$+$Au collisions at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. The data are well represented by L\'evy-stable source distributions. The extracted source parameters are the correlation-strength parameter $\lambda$, the L\'evy index of stability $\alpha$, and the L\'evy-scale parameter $R$ as a function of transverse mass $m_T$ and centrality. The $\lambda(m_T)$ parameter is constant at larger values of $m_T$, but decreases as $m_T$ decreases. The L\'evy scale parameter $R(m_T)$ decreases with $m_T$ and exhibits proportionality to the length scale of the nuclear overlap region. The L\'evy exponent $\alpha(m_T)$ is independent of $m_T$ within uncertainties in each investigated centrality bin, but shows a clear centrality dependence. At all centralities, the L\'evy exponent $\alpha$ is significantly different from that of Gaussian ($\alpha=2$) or Cauchy ($\alpha=1$) source distributions. Comparisons to the predictions of Monte-Carlo simulations of resonance-decay chains show that in all but the most peripheral centrality class (50%-60%), the obtained results are inconsistent with the measurements, unless a significant reduction of the in-medium mass of the $\eta'$ meson is included. In each centrality class, the best value of the in-medium $\eta'$ mass is compared to the mass of the $\eta$ meson, as well as to several theoretical predictions that consider restoration of $U_A(1)$ symmetry in hot hadronic matter., Comment: 401 authors from 75 institutions, 20 pages, 15 figures, 2 tables. v1 is version submitted to Physical Review C. HEPdata tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html
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- 2024
3. Parameterized Algorithms for Covering by Arithmetic Progressions
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Bliznets, Ivan, Nederlof, Jesper, and Szilágyi, Krisztina
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Computer Science - Computational Complexity ,11Y16 ,F.2 - Abstract
An arithmetic progression is a sequence of integers in which the difference between any two consecutive elements is the same. We investigate the parameterized complexity of two problems related to arithmetic progressions, called Cover by Arithmetic Progressions (CAP) and Exact Cover by Arithmetic Progressions (XCAP). In both problems, we are given a set $X$ consisting of $n$ integers along with an integer $k$, and our goal is to find $k$ arithmetic progressions whose union is $X$. In XCAP we additionally require the arithmetic progressions to be disjoint. Both problems were shown to be NP-complete by Heath [IPL'90]. We present a $2^{O(k^2)} poly(n)$ time algorithm for CAP and a $2^{O(k^3)} poly(n)$ time algorithm for XCAP. We also give a fixed parameter tractable algorithm for CAP parameterized below some guaranteed solution size. We complement these findings by proving that CAP is Strongly NP-complete in the field $\mathbb{Z}_p$, if $p$ is a prime number part of the input.
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- 2023
4. Algorithms and Turing Kernels for Detecting and Counting Small Patterns in Unit Disk Graphs
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Nederlof, Jesper and Szilágyi, Krisztina
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Computer Science - Computational Complexity ,05C85 ,F.2 - Abstract
In this paper we investigate the parameterized complexity of the task of counting and detecting occurrences of small patterns in unit disk graphs: Given an $n$-vertex unit disk graph $G$ with an embedding of ply $p$ (that is, the graph is represented as intersection graph with closed disks of unit size, and each point is contained in at most $p$ disks) and a $k$-vertex unit disk graph $P$, count the number of (induced) copies of $P$ in $G$. For general patterns $P$, we give an $2^{O(p k /\log k)}n^{O(1)}$ time algorithm for counting pattern occurrences. We show this is tight, even for ply $p=2$ and $k=n$: any $2^{o(n/\log n)}n^{O(1)}$ time algorithm violates the Exponential Time Hypothesis (ETH). For most natural classes of patterns, such as connected graphs and independent sets we present the following results: First, we give an $(pk)^{O(\sqrt{pk})}n^{O(1)}$ time algorithm, which is nearly tight under the ETH for bounded ply and many patterns. Second, for $p= k^{O(1)}$ we provide a Turing kernelization (i.e. we give a polynomial time preprocessing algorithm to reduce the instance size to $k^{O(1)}$). Our approach combines previous tools developed for planar subgraph isomorphism such as `efficient inclusion-exclusion' from [Nederlof STOC'20], and `isomorphisms checks' from [Bodlaender et al. ICALP'16] with a different separator hierarchy and a new bound on the number of non-isomorphic separations of small order tailored for unit disk graphs.
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- 2023
5. Towards Tight Bounds for the Graph Homomorphism Problem Parameterized by Cutwidth via Asymptotic Rank Parameters
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Groenland, Carla, Mannens, Isja, Nederlof, Jesper, Piecyk, Marta, and Rzążewski, Paweł
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Computer Science - Discrete Mathematics ,Computer Science - Computational Complexity - Abstract
A homomorphism from a graph $G$ to a graph $H$ is an edge-preserving mapping from $V(G)$ to $V(H)$. In the graph homomorphism problem, denoted by $Hom(H)$, the graph $H$ is fixed and we need to determine if there exists a homomorphism from an instance graph $G$ to $H$. We study the complexity of the problem parameterized by the cutwidth of $G$. We aim, for each $H$, for algorithms for $Hom(H)$ running in time $c_H^k n^{\mathcal{O}(1)}$ and matching lower bounds that exclude $c_H^{k \cdot o(1)}n^{\mathcal{O}(1)}$ or $c_H^{k(1-\Omega(1))}n^{\mathcal{O}(1)}$ time algorithms under the (Strong) Exponential Time Hypothesis. In the paper we introduce a new parameter that we call $\mathrm{mimsup}(H)$. Our main contribution is strong evidence of a close connection between $c_H$ and $\mathrm{mimsup}(H)$: * an information-theoretic argument that the number of states needed in a natural dynamic programming algorithm is at most $\mathrm{mimsup}(H)^k$, * lower bounds that show that for almost all graphs $H$ indeed we have $c_H \geq \mathrm{mimsup}(H)$, assuming the (Strong) Exponential-Time Hypothesis, and * an algorithm with running time $\exp ( {\mathcal{O}( \mathrm{mimsup}(H) \cdot k \log k)}) n^{\mathcal{O}(1)}$. The parameter $\mathrm{mimsup}(H)$ can be thought of as the $p$-th root of the maximum induced matching number in the graph obtained by multiplying $p$ copies of $H$ via certain graph product, where $p$ tends to infinity. It can also be defined as an asymptotic rank parameter of the adjacency matrix of $H$. Our results tightly link the parameterized complexity of a problem to such an asymptotic rank parameter for the first time.
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- 2023
6. A Subexponential Time Algorithm for Makespan Scheduling of Unit Jobs with Precedence Constraints
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Nederlof, Jesper, Swennenhuis, Céline M. F., and Węgrzycki, Karol
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Computer Science - Data Structures and Algorithms - Abstract
In a classical scheduling problem, we are given a set of $n$ jobs of unit length along with precedence constraints, and the goal is to find a schedule of these jobs on $m$ identical machines that minimizes the makespan. Using the standard 3-field notation, it is known as $Pm|\text{prec}, p_j=1|C_{\max}$. Settling the complexity of $Pm|\text{prec}, p_j=1|C_{\max}$ even for $m=3$ machines is the last open problem from the book of Garey and Johnson [GJ79] for which both upper and lower bounds on the worst-case running times of exact algorithms solving them remain essentially unchanged since the publication of [GJ79]. We present an algorithm for this problem that runs in $(1+\frac{n}{m})^{\mathcal{O}(\sqrt{nm})}$ time. This algorithm is subexponential when $m = o(n)$. In the regime of $m=\Theta(n)$ we show an algorithm that runs in$\mathcal{O}(1.997^n)$ time. Before our work, even for $m=3$ machines there were no algorithms known that run in $\mathcal{O}((2-\varepsilon)^n)$ time for some $\varepsilon > 0$.
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- 2023
7. Insulin and glycolysis dependency of cardioprotection by nicotinamide riboside
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Xiao, Y., Wang, Q., Zhang, H., Nederlof, R., Bakker, D., Siadari, B. A., Wesselink, M. W., Preckel, B., Weber, N. C., Hollmann, M. W., Schomakers, B. V., van Weeghel, M., and Zuurbier, C. J.
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- 2024
- Full Text
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8. Another Hamiltonian Cycle in Bipartite Pfaffian Graphs
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Björklund, Andreas, Kaski, Petteri, and Nederlof, Jesper
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Computer Science - Data Structures and Algorithms - Abstract
Finding a Hamiltonian cycle in a given graph is computationally challenging, and in general remains so even when one is further given one Hamiltonian cycle in the graph and asked to find another. In fact, no significantly faster algorithms are known for finding another Hamiltonian cycle than for finding a first one even in the setting where another Hamiltonian cycle is structurally guaranteed to exist, such as for odd-degree graphs. We identify a graph class -- the bipartite Pfaffian graphs of minimum degree three -- where it is NP-complete to decide whether a given graph in the class is Hamiltonian, but when presented with a Hamiltonian cycle as part of the input, another Hamiltonian cycle can be found efficiently. We prove that Thomason's lollipop method~[Ann.~Discrete Math.,~1978], a well-known algorithm for finding another Hamiltonian cycle, runs in a linear number of steps in cubic bipartite Pfaffian graphs. This was conjectured for cubic bipartite planar graphs by Haddadan [MSc~thesis,~Waterloo,~2015]; in contrast, examples are known of both cubic bipartite graphs and cubic planar graphs where the lollipop method takes exponential time. Beyond the lollipop method, we address a slightly more general graph class and present two algorithms, one running in linear-time and one operating in logarithmic space, that take as input (i) a bipartite Pfaffian graph $G$ of minimum degree three, (ii) a Hamiltonian cycle $H$ in $G$, and (iii) an edge $e$ in $H$, and output at least three other Hamiltonian cycles through the edge $e$ in $G$. We also present further improved algorithms for finding optimal traveling salesperson tours and counting Hamiltonian cycles in bipartite planar graphs with running times that are not known to hold in general planar graphs., Comment: Adds analysis of Thomason's lollipop method
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- 2023
9. Polynomial-time Approximation of Independent Set Parameterized by Treewidth
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Chalermsook, Parinya, Fomin, Fedor, Hamm, Thekla, Korhonen, Tuukka, Nederlof, Jesper, and Orgo, Ly
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Computer Science - Data Structures and Algorithms - Abstract
We prove the following result about approximating the maximum independent set in a graph. Informally, we show that any approximation algorithm with a ``non-trivial'' approximation ratio (as a function of the number of vertices of the input graph $G$) can be turned into an approximation algorithm achieving almost the same ratio, albeit as a function of the treewidth of $G$. More formally, we prove that for any function $f$, the existence of a polynomial time $(n/f(n))$-approximation algorithm yields the existence of a polynomial time $O(tw \cdot\log{f(tw)}/f(tw))$-approximation algorithm, where $n$ and $tw$ denote the number of vertices and the width of a given tree decomposition of the input graph. By pipelining our result with the state-of-the-art $O(n \cdot (\log \log n)^2/\log^3 n)$-approximation algorithm by Feige (2004), this implies an $O(tw \cdot (\log \log tw)^3/\log^3 tw)$-approximation algorithm., Comment: To appear in the 31st Annual European Symposium on Algorithms (ESA 2023)
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- 2023
10. A Fine-Grained Classification of the Complexity of Evaluating the Tutte Polynomial on Integer Points Parameterized by Treewidth and Cutwidth
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Mannens, Isja and Nederlof, Jesper
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Computer Science - Computational Complexity ,Computer Science - Data Structures and Algorithms - Abstract
We give a fine-grained classification of evaluating the Tutte polynomial $T(G;x,y)$ on all integer points on graphs with small treewidth and cutwidth. Specifically, we show for any point $(x,y) \in \mathbb{Z}^2$ that either - can be computed in polynomial time, - can be computed in $2^{O(tw)}n^{O(1)}$ time, but not in $2^{o(ctw)}n^{O(1)}$ time assuming the Exponential Time Hypothesis (ETH), - can be computed in $2^{O(tw \log tw)}n^{O(1)}$ time, but not in $2^{o(ctw \log ctw)}n^{O(1)}$ time assuming the ETH, where we assume tree decompositions of treewidth $tw$ and cutwidth decompositions of cutwidth $ctw$ are given as input along with the input graph on $n$ vertices and point $(x,y)$. To obtain these results, we refine the existing reductions that were instrumental for the seminal dichotomy by Jaeger, Welsh and Vertigan~[Math. Proc. Cambridge Philos. Soc'90]. One of our technical contributions is a new rank bound of a matrix that indicates whether the union of two forests is a forest itself, which we use to show that the number of forests of a graph can be counted in $2^{O(tw)}n^{O(1)}$ time., Comment: Suplementary code found at: https://github.com/isja-m/ForestRank4-5
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- 2023
11. Ultra high content analyses of circulating and tumor associated hybrid cells reveal phenotypic heterogeneity
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Whalen, Riley M., Anderson, Ashley N., Jones, Jocelyn A., Sims, Zachary, Chang, Young Hwan, Nederlof, Michel A., Wong, Melissa H., and Gibbs, Summer L.
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- 2024
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12. Long-term outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 status
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Wang, Yuwei, Dackus, Gwen M. H. E., Rosenberg, Efraim H., Cornelissen, Sten, de Boo, Leonora W., Broeks, Annegien, Brugman, Wim, Chan, Terry W. S., van Diest, Paul J., Hauptmann, Michael, ter Hoeve, Natalie D., Isaeva, Olga I., de Jong, Vincent M. T., Jóźwiak, Katarzyna, Kluin, Roelof J. C., Kok, Marleen, Koop, Esther, Nederlof, Petra M., Opdam, Mark, Schouten, Philip C., Siesling, Sabine, van Steenis, Charlaine, Voogd, Adri C., Vreuls, Willem, Salgado, Roberto F., Linn, Sabine C., and Schmidt, Marjanka K.
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- 2024
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13. The cultivation of Primula palinuri Petagna for ex situ conservation: lessons learned from the Royal Rotterdam Zoological and Botanical Gardens
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Louwerens-Jan Nederlof, Giovanna Aronne, and Sergio Mugnai
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Botany ,QK1-989 - Abstract
Primula palinuri Petagna is an endangered species endemic to a tiny coastal area in southern Italy. Investigating the possibility of growing and propagating this endangered species with ex situ actions should be encouraged, as this could provide a second line of security for rare plants by allowing specimens to be grown in the absence of natural environmental challenges. Currently, the Royal Rotterdam Zoological and Botanical Gardens (RRZBG) hold 31 accessions of P. palinuri, which represents an ex situ collection with potential value for conservation programmes. Over the years, horticulturists at RRZBG have created a solid protocol to produce viable seeds through hand-pollination techniques, thus allowing conservation programmes for this species to become more effective. In this article the cultivation of the species is described, including information on seed germination, general maintenance, cultivation to flowering stage and propagation from the resulting seeds.
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- 2024
14. Towards Tight Bounds for the Graph Homomorphism Problem Parameterized by Cutwidth via Asymptotic Matrix Parameters.
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Carla Groenland, Isja Mannens, Jesper Nederlof, Marta Piecyk, and Pawel Rzazewski
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- 2024
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15. Another Hamiltonian Cycle in Bipartite Pfaffian Graphs.
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Andreas Björklund, Petteri Kaski, and Jesper Nederlof
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- 2024
- Full Text
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16. Algorithms and Turing Kernels for Detecting and Counting Small Patterns in Unit Disk Graphs.
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Jesper Nederlof and Krisztina Szilágyi
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- 2024
- Full Text
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17. Exact and Parameterized Algorithms for Choosability.
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Ivan Bliznets and Jesper Nederlof
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- 2024
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18. Parameterized Algorithms for Covering by Arithmetic Progressions.
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Ivan Bliznets, Jesper Nederlof, and Krisztina Szilágyi
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- 2024
- Full Text
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19. Parameterized Algorithms for Covering by Arithmetic Progressions
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Bliznets, Ivan, Nederlof, Jesper, Szilágyi, Krisztina, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Fernau, Henning, editor, Gaspers, Serge, editor, and Klasing, Ralf, editor
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- 2024
- Full Text
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20. Exact and Parameterized Algorithms for Choosability
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Bliznets, Ivan, Nederlof, Jesper, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Fernau, Henning, editor, Gaspers, Serge, editor, and Klasing, Ralf, editor
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- 2024
- Full Text
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21. Algorithms and Turing Kernels for Detecting and Counting Small Patterns in Unit Disk Graphs
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Nederlof, Jesper, Szilágyi, Krisztina, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Fernau, Henning, editor, Gaspers, Serge, editor, and Klasing, Ralf, editor
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- 2024
- Full Text
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22. Tight Lower Bounds for Problems Parameterized by Rank-width
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Bergougnoux, Benjamin, Korhonen, Tuukka, and Nederlof, Jesper
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Computer Science - Data Structures and Algorithms ,68Q27 - Abstract
We show that there is no $2^{o(k^2)} n^{O(1)}$ time algorithm for Independent Set on $n$-vertex graphs with rank-width $k$, unless the Exponential Time Hypothesis (ETH) fails. Our lower bound matches the $2^{O(k^2)} n^{O(1)}$ time algorithm given by Bui-Xuan, Telle, and Vatshelle [Discret. Appl. Math., 2010] and it answers the open question of Bergougnoux and Kant\'{e} [SIAM J. Discret. Math., 2021]. We also show that the known $2^{O(k^2)} n^{O(1)}$ time algorithms for Weighted Dominating Set, Maximum Induced Matching and Feedback Vertex Set parameterized by rank-width $k$ are optimal assuming ETH. Our results are the first tight ETH lower bounds parameterized by rank-width that do not follow directly from lower bounds for $n$-vertex graphs., Comment: Accepted to STACS'23
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- 2022
23. Makespan Scheduling of Unit Jobs with Precedence Constraints in $O(1.995^n)$ time
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Nederlof, Jesper, Swennenhuis, Céline M. F., and Węgrzycki, Karol
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Computer Science - Data Structures and Algorithms - Abstract
In a classical scheduling problem, we are given a set of $n$ jobs of unit length along with precedence constraints and the goal is to find a schedule of these jobs on $m$ identical machines that minimizes the makespan. This problem is well-known to be NP-hard for an unbounded number of machines. Using standard 3-field notation, it is known as $P|\text{prec}, p_j=1|C_{\max}$. We present an algorithm for this problem that runs in $O(1.995^n)$ time. Before our work, even for $m=3$ machines the best known algorithms ran in $O^\ast(2^n)$ time. In contrast, our algorithm works when the number of machines $m$ is unbounded. A crucial ingredient of our approach is an algorithm with a runtime that is only single-exponential in the vertex cover of the comparability graph of the precedence constraint graph. This heavily relies on insights from a classical result by Dolev and Warmuth (Journal of Algorithms 1984) for precedence graphs without long chains., Comment: 26 pages, 7 figures
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- 2022
24. Ultra high content analyses of circulating and tumor associated hybrid cells reveal phenotypic heterogeneity
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Riley M. Whalen, Ashley N. Anderson, Jocelyn A. Jones, Zachary Sims, Young Hwan Chang, Michel A. Nederlof, Melissa H. Wong, and Summer L. Gibbs
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Cyclic immunofluorescence ,Circulating hybrid cell ,Cancer biomarker ,Oligonucleotide-conjugated antibody ,Cancer progression ,Colorectal cancer ,Medicine ,Science - Abstract
Abstract Persistently high, worldwide mortality from cancer highlights the unresolved challenges of disease surveillance and detection that impact survival. Development of a non-invasive, blood-based biomarker would transform survival from cancer. We demonstrate the functionality of ultra-high content analyses of a newly identified population of tumor cells that are hybrids between neoplastic and immune cells in patient matched tumor and peripheral blood specimens. Using oligonucleotide conjugated antibodies (Ab-oligo) permitting cyclic immunofluorescence (cyCIF), we present analyses of phenotypes among tumor and peripheral blood hybrid cells. Interestingly, the majority of circulating hybrid cell (CHC) subpopulations were not identified in tumor-associated hybrids. These results highlight the efficacy of ultra-high content phenotypic analyses using Ab-oligo based cyCIF applied to both tumor and peripheral blood specimens. The combination of a multiplex phenotypic profiling platform that is gentle enough to analyze blood to detect and evaluate disseminated tumor cells represents a novel approach to exploring novel tumor biology and potential utility for developing the population as a blood-based biomarker in cancer.
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- 2024
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25. Correction to: Parameterized Algorithms for Covering by Arithmetic Progressions
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Bliznets, Ivan, primary, Nederlof, Jesper, additional, and Szilágyi, Krisztina, additional
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- 2024
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26. Low-$p_T$ direct-photon production in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=39$ and 62.4 GeV
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Abdulameer, N. J., Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Ta'ani, H., Alexander, J., Alfred, M., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bannier, B., Barish, K. N., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Roman, V. Canoa, Castera, P., Chen, C. -H., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Corliss, R., Morales, Y. Corrales, Csanád, M., Csörgő, T., D'Orazio, L., Dairaku, S., Datta, A., Daugherity, M. S., David, G., Dean, C. T., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Doomra, V., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Fan, W., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Giles, M., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Harvey, M., Hasegawa, S., Hashimoto, K., Haslum, E., Hayano, R., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Huang, J., Ichihara, T., Iinuma, H., Ikeda, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Issah, M., Ivanishchev, D., Jacak, B. V., Javani, M., Jiang, X., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kazantsev, A. V., Kempel, T., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. J., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, T., Kim, Y. -J., Kim, Y. K., Kincses, D., Kingan, A., Kinney, E., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kovacs, L., Krizek, F., Král, A., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lai, Y. S., Lajoie, J. G., Larionova, D., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Lewis, N. A., Lim, S. H., Levy, L. A. Linden, Liu, M. X., Li, X., Loomis, D. A., Love, B., Lökös, S., Maguire, C. F., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Mohapatra, S., Mondal, M. M., Moon, H. J., Moon, T., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Muhammad, A., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nelson, S., Nihashi, M., Nouicer, R., Novák, T., Novitzky, N., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oh, J., Okada, K., Orosz, M., Osborn, J. D., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J. S., Park, S., Park, S. K., Patel, L., Patel, M., Pate, S. F., Pei, H., Peng, J. -C., Peng, W., Pereira, H., Perepelitsa, D. V., Peressounko, D. Yu., PerezLara, C. E., Petti, R., Pinkenburg, C., Pisani, R. P., Potekhin, M., Proissl, M., Pun, A., Purschke, M. L., Qu, H., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Runchey, J., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sano, M., Sarsour, M., Sato, S., Sawada, S., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sharma, D., Shein, I., Shi, Z., Shibata, M., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sun, Z., Sziklai, J., Takagui, E. M., Takahama, R., Takahara, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Themann, H., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Ueda, Y., Ujvari, B., Vale, C., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Vértesi, R., Velkovska, J., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Wang, X. R., Wang, Z., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., White, S. N., Winter, D., Wolin, S., Wong, C. P., Woody, C. L., Wysocki, M., Xia, B., Yamaguchi, Y. L., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Younus, I., You, Z., Yushmanov, I. E., Zajc, W. A., Zelenski, A., and Zou, L.
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Nuclear Experiment - Abstract
The measurement of direct photons from Au$+$Au collisions at $\sqrt{s_{_{NN}}}=39$ and 62.4 GeV in the transverse-momentum range $0.4
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- 2022
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27. Effect of dietary starch on digestion kinetics and nutrient utilization in yellowtail kingfish (Seriola lalandi)
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Horstmann Zuther, P., Maas, Roel M., Blok, Tijmen, Kals, Jeroen, Nederlof, Marit A.J., Prakash, Satya, Schols, Henk A., Staessen, Thomas W.O., Zhang, Yaqing, Kokou, Fotini, and Schrama, Johan W.
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- 2024
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28. Parameterized problems complete for nondeterministic FPT time and logarithmic space
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Bodlaender, Hans L., Groenland, Carla, Nederlof, Jesper, and Swennenhuis, Céline
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- 2024
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29. Long-term outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 status
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Yuwei Wang, Gwen M. H. E. Dackus, Efraim H. Rosenberg, Sten Cornelissen, Leonora W. de Boo, Annegien Broeks, Wim Brugman, Terry W. S. Chan, Paul J. van Diest, Michael Hauptmann, Natalie D. ter Hoeve, Olga I. Isaeva, Vincent M. T. de Jong, Katarzyna Jóźwiak, Roelof J. C. Kluin, Marleen Kok, Esther Koop, Petra M. Nederlof, Mark Opdam, Philip C. Schouten, Sabine Siesling, Charlaine van Steenis, Adri C. Voogd, Willem Vreuls, Roberto F. Salgado, Sabine C. Linn, and Marjanka K. Schmidt
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BRCA1 status ,Tumor-infiltrating lymphocytes ,Triple-negative breast cancer ,Chemotherapy-naïve ,Long-term outcomes ,Risk classification ,Medicine - Abstract
Abstract Background Due to the abundant usage of chemotherapy in young triple-negative breast cancer (TNBC) patients, the unbiased prognostic value of BRCA1-related biomarkers in this population remains unclear. In addition, whether BRCA1-related biomarkers modify the well-established prognostic value of stromal tumor-infiltrating lymphocytes (sTILs) is unknown. This study aimed to compare the outcomes of young, node-negative, chemotherapy-naïve TNBC patients according to BRCA1 status, taking sTILs into account. Methods We included 485 Dutch women diagnosed with node-negative TNBC under age 40 between 1989 and 2000. During this period, these women were considered low-risk and did not receive chemotherapy. BRCA1 status, including pathogenic germline BRCA1 mutation (gBRCA1m), somatic BRCA1 mutation (sBRCA1m), and tumor BRCA1 promoter methylation (BRCA1-PM), was assessed using DNA from formalin-fixed paraffin-embedded tissue. sTILs were assessed according to the international guideline. Patients’ outcomes were compared using Cox regression and competing risk models. Results Among the 399 patients with BRCA1 status, 26.3% had a gBRCA1m, 5.3% had a sBRCA1m, 36.6% had tumor BRCA1-PM, and 31.8% had BRCA1-non-altered tumors. Compared to BRCA1-non-alteration, gBRCA1m was associated with worse overall survival (OS) from the fourth year after diagnosis (adjusted HR, 2.11; 95% CI, 1.18–3.75), and this association attenuated after adjustment for second primary tumors. Every 10% sTIL increment was associated with 16% higher OS (adjusted HR, 0.84; 95% CI, 0.78–0.90) in gBRCA1m, sBRCA1m, or BRCA1-non-altered patients and 31% higher OS in tumor BRCA1-PM patients. Among the 66 patients with tumor BRCA1-PM and ≥ 50% sTILs, we observed excellent 15-year OS (97.0%; 95% CI, 92.9–100%). Conversely, among the 61 patients with gBRCA1m and
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- 2024
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30. Bounding generalized coloring numbers of planar graphs using coin models
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Nederlof, Jesper, Pilipczuk, Michał, and Węgrzycki, Karol
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Mathematics - Combinatorics ,Computer Science - Discrete Mathematics - Abstract
We study Koebe orderings of planar graphs: vertex orderings obtained by modelling the graph as the intersection graph of pairwise internally-disjoint discs in the plane, and ordering the vertices by non-increasing radii of the associated discs. We prove that for every $d\in \mathbb{N}$, any such ordering has $d$-admissibility bounded by $O(d/\ln d)$ and weak $d$-coloring number bounded by $O(d^4 \ln d)$. This in particular shows that the $d$-admissibility of planar graphs is bounded by $O(d/\ln d)$, which asymptotically matches a known lower bound due to Dvo\v{r}\'ak and Siebertz., Comment: 19 pages, 6 figures
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- 2022
31. Effect of temperature on the digestibility of non-starch polysaccharide-rich ingredients in Nile tilapia (Oreochromis niloticus)
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Dey, B.K., Verdegem, M.C.J., Nederlof, M.A.J., Beddow, J.M., Masagounder, K., Mas-Muñoz, J., and Schrama, J.W.
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- 2024
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32. Tight bounds for counting colorings and connected edge sets parameterized by cutwidth
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Groenland, Carla, Nederlof, Jesper, Mannens, Isja, and Szilágyi, Krisztina
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Computer Science - Data Structures and Algorithms ,Computer Science - Computational Complexity - Abstract
We study the fine-grained complexity of counting the number of colorings and connected spanning edge sets parameterized by the cutwidth and treewidth of the graph. While decompositions of small treewidth decompose the graph with small vertex separators, decompositions with small cutwidth decompose the graph with small \emph{edge} separators. Let $p,q \in \mathbb{N}$ such that $p$ is a prime and $q \geq 3$. - If $p$ divides $q-1$, there is a $(q-1)^{\text{ctw}}n^{O(1)}$ time algorithm for counting list $q$-colorings modulo $p$ of $n$-vertex graphs of cutwidth $\text{ctw}$ and for all $\varepsilon>0$ there is no algorithm running in time $(q-1-\varepsilon)^{\text{ctw}} n^{O(1)}$, assuming the Strong Exponential Time Hypothesis (SETH). - If $p$ does not divide $q-1$, there is a (folklore) $q^{\text{ctw}}n^{O(1)}$ time algorithm for counting list $q$-colorings modulo $p$ of $n$-vertex graphs of cutwidth $\text{ctw}$ and for all $\varepsilon>0$ there is no algorithm running in time $(q-\varepsilon)^{\text{ctw}} n^{O(1)}$, assuming SETH. The lower bounds are in stark contrast with the existing $2^{\text{ctw}}n^{O(1)}$ time algorithm to compute the chromatic number of a graph by Jansen and Nederlof~[Theor. Comput. Sci.'18]. Both our algorithms and lower bounds employ use of the matrix rank method, by relating the complexity of the problem to the rank of a certain `compatibility matrix' in a non-trivial way. We extend our lower bounds to counting connected spanning edge sets modulo $p$ and give an algorithm with matching running time for both treewidth and cutwidth.
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- 2021
33. High-dose alkylating chemotherapy in BRCA-altered triple-negative breast cancer: the randomized phase III NeoTN trial
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Vliek, Sonja, Hilbers, Florentine S., van Werkhoven, Erik, Mandjes, Ingrid, Kessels, Rob, Kleiterp, Sieta, Lips, Esther H., Mulder, Lennart, Kayembe, Mutamba T., Loo, Claudette E., Russell, Nicola S., Vrancken Peeters, Marie-Jeanne T. F. D., Holtkamp, Marjo J., Schot, Margaret, Baars, Joke W., Honkoop, Aafke H., Vulink, Annelie J. E., Imholz, Alex L. T., Vrijaldenhoven, Suzan, van den Berkmortel, Franchette W. P. J., Meerum Terwogt, Jetske M., Schrama, Jolanda G., Kuijer, Philomeen, Kroep, Judith R., van der Padt-Pruijsten, Annemieke, Wesseling, Jelle, Sonke, Gabe S., Gilhuijs, Kenneth G. A., Jager, Agnes, Nederlof, Petra, and Linn, Sabine C.
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- 2023
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34. DeepSMILE: Contrastive self-supervised pre-training benefits MSI and HRD classification directly from H&E whole-slide images in colorectal and breast cancer
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Schirris, Yoni, Gavves, Efstratios, Nederlof, Iris, Horlings, Hugo Mark, and Teuwen, Jonas
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
We propose a Deep learning-based weak label learning method for analyzing whole slide images (WSIs) of Hematoxylin and Eosin (H&E) stained tumor tissue not requiring pixel-level or tile-level annotations using Self-supervised pre-training and heterogeneity-aware deep Multiple Instance LEarning (DeepSMILE). We apply DeepSMILE to the task of Homologous recombination deficiency (HRD) and microsatellite instability (MSI) prediction. We utilize contrastive self-supervised learning to pre-train a feature extractor on histopathology tiles of cancer tissue. Additionally, we use variability-aware deep multiple instance learning to learn the tile feature aggregation function while modeling tumor heterogeneity. For MSI prediction in a tumor-annotated and color normalized subset of TCGA-CRC (n=360 patients), contrastive self-supervised learning improves the tile supervision baseline from 0.77 to 0.87 AUROC, on par with our proposed DeepSMILE method. On TCGA-BC (n=1041 patients) without any manual annotations, DeepSMILE improves HRD classification performance from 0.77 to 0.81 AUROC compared to tile supervision with either a self-supervised or ImageNet pre-trained feature extractor. Our proposed methods reach the baseline performance using only 40% of the labeled data on both datasets. These improvements suggest we can use standard self-supervised learning techniques combined with multiple instance learning in the histopathology domain to improve genomic label classification performance with fewer labeled data., Comment: Main paper: 14 pages, 2 tables, 1 algorithm, 3 figures. Supplementary material: 3 pages
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- 2021
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35. On the Parameterized Complexity of the Connected Flow and Many Visits TSP Problem
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Mannens, Isja, Nederlof, Jesper, Swennenhuis, Céline, and Szilágyi, Krisztina
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Computer Science - Data Structures and Algorithms ,Computer Science - Computational Complexity ,Computer Science - Discrete Mathematics - Abstract
We study a variant of Min Cost Flow in which the flow needs to be connected. Specifically, in the Connected Flow problem one is given a directed graph $G$, along with a set of demand vertices $D \subseteq V(G)$ with demands $\mathsf{dem}: D \rightarrow \mathbb{N}$, and costs and capacities for each edge. The goal is to find a minimum cost flow that satisfies the demands, respects the capacities and induces a (strongly) connected subgraph. This generalizes previously studied problems like the (Many Visits) TSP. We study the parameterized complexity of Connected Flow parameterized by $|D|$, the treewidth $tw$ and by vertex cover size $k$ of $G$ and provide: (i) $\mathsf{NP}$-completeness already for the case $|D|=2$ with only unit demands and capacities and no edge costs, and fixed-parameter tractability if there are no capacities, (ii) a fixed-parameter tractable $\mathcal{O}^{\star}(k^{\mathcal{O}(k)})$ time algorithm for the general case, and a kernel of size polynomial in $k$ for the special case of Many Visits TSP, (iii) a $|V(G)|^{\mathcal{O}(tw)}$ time algorithm and a matching $|V(G)|^{o(tw)}$ time conditional lower bound conditioned on the Exponential Time Hypothesis. To achieve some of our results, we significantly extend an approach by Kowalik et al.~[ESA'20]., Comment: To be included in the proceedings of the 'International Workshop on Graph-Theoretic Concepts in Computer Science' (WG2021)
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- 2021
36. Parameterized Problems Complete for Nondeterministic FPT time and Logarithmic Space
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Bodlaender, Hans L., Groenland, Carla, Nederlof, Jesper, and Swennenhuis, Céline M. F.
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Computer Science - Computational Complexity - Abstract
Let XNLP be the class of parameterized problems such that an instance of size n with parameter k can be solved nondeterministically in time $f(k)n^{O(1)}$ and space $f(k)\log(n)$ (for some computable function f). We give a wide variety of XNLP-complete problems, such as List Coloring and Precoloring Extension with pathwidth as parameter, Scheduling of Jobs with Precedence Constraints, with both number of machines and partial order width as parameter, Bandwidth and variants of Weighted CNF-Satisfiability. In particular, this implies that all these problems are W[t]-hard for all t. This also answers a long standing question on the parameterized complexity of the Bandwidth problem.
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- 2021
37. Isolation schemes for problems on decomposable graphs
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Nederlof, Jesper, Pilipczuk, Michał, Swennenhuis, Céline M. F., and Węgrzycki, Karol
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Computer Science - Computational Complexity ,Computer Science - Data Structures and Algorithms - Abstract
The Isolation Lemma of Mulmuley, Vazirani and Vazirani [Combinatorica'87] provides a self-reduction scheme that allows one to assume that a given instance of a problem has a unique solution, provided a solution exists at all. Since its introduction, much effort has been dedicated towards derandomization of the Isolation Lemma for specific classes of problems. So far, the focus was mainly on problems solvable in polynomial time. In this paper, we study a setting that is more typical for $\mathsf{NP}$-complete problems, and obtain partial derandomizations in the form of significantly decreasing the number of required random bits. In particular, motivated by the advances in parameterized algorithms, we focus on problems on decomposable graphs. For example, for the problem of detecting a Hamiltonian cycle, we build upon the rank-based approach from [Bodlaender et al., Inf. Comput.'15] and design isolation schemes that use - $O(t\log n + \log^2{n})$ random bits on graphs of treewidth at most $t$; - $O(\sqrt{n})$ random bits on planar or $H$-minor free graphs; and - $O(n)$-random bits on general graphs. In all these schemes, the weights are bounded exponentially in the number of random bits used. As a corollary, for every fixed $H$ we obtain an algorithm for detecting a Hamiltonian cycle in an $H$-minor-free graph that runs in deterministic time $2^{O(\sqrt{n})}$ and uses polynomial space; this is the first algorithm to achieve such complexity guarantees. For problems of more local nature, such as finding an independent set of maximum size, we obtain isolation schemes on graphs of treedepth at most $d$ that use $O(d)$ random bits and assign polynomially-bounded weights. We also complement our findings with several unconditional and conditional lower bounds, which show that many of the results cannot be significantly improved., Comment: 54 pages, 9 figures
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- 2021
38. High-dose alkylating chemotherapy in BRCA-altered triple-negative breast cancer: the randomized phase III NeoTN trial
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Sonja Vliek, Florentine S. Hilbers, Erik van Werkhoven, Ingrid Mandjes, Rob Kessels, Sieta Kleiterp, Esther H. Lips, Lennart Mulder, Mutamba T. Kayembe, Claudette E. Loo, Nicola S. Russell, Marie-Jeanne T. F. D. Vrancken Peeters, Marjo J. Holtkamp, Margaret Schot, Joke W. Baars, Aafke H. Honkoop, Annelie J. E. Vulink, Alex L. T. Imholz, Suzan Vrijaldenhoven, Franchette W. P. J. van den Berkmortel, Jetske M. Meerum Terwogt, Jolanda G. Schrama, Philomeen Kuijer, Judith R. Kroep, Annemieke van der Padt-Pruijsten, Jelle Wesseling, Gabe S. Sonke, Kenneth G. A. Gilhuijs, Agnes Jager, Petra Nederlof, and Sabine C. Linn
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Exploratory analyses of high-dose alkylating chemotherapy trials have suggested that BRCA1 or BRCA2-pathway altered (BRCA-altered) breast cancer might be particularly sensitive to this type of treatment. In this study, patients with BRCA-altered tumors who had received three initial courses of dose-dense doxorubicin and cyclophosphamide (ddAC), were randomized between a fourth ddAC course followed by high-dose carboplatin-thiotepa-cyclophosphamide or conventional chemotherapy (initially ddAC only or ddAC-capecitabine/decetaxel [CD] depending on MRI response, after amendment ddAC-carboplatin/paclitaxel [CP] for everyone). The primary endpoint was the neoadjuvant response index (NRI). Secondary endpoints included recurrence-free survival (RFS) and overall survival (OS). In total, 122 patients were randomized. No difference in NRI-score distribution (p = 0.41) was found. A statistically non-significant RFS difference was found (HR 0.54; 95% CI 0.23–1.25; p = 0.15). Exploratory RFS analyses showed benefit in stage III (n = 35; HR 0.16; 95% CI 0.03–0.75), but not stage II (n = 86; HR 1.00; 95% CI 0.30–3.30) patients. For stage III, 4-year RFS was 46% (95% CI 24–87%), 71% (95% CI 48–100%) and 88% (95% CI 74–100%), for ddAC/ddAC-CD, ddAC-CP and high-dose chemotherapy, respectively. No significant differences were found between high-dose and conventional chemotherapy in stage II-III, triple-negative, BRCA-altered breast cancer patients. Further research is needed to establish if there are patients with stage III, triple negative BRCA-altered breast cancer for whom outcomes can be improved with high-dose alkylating chemotherapy or whether the current standard neoadjuvant therapy including carboplatin and an immune checkpoint inhibitor is sufficient. Trial Registration: NCT01057069.
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- 2023
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39. A Gap-ETH-Tight Approximation Scheme for Euclidean TSP
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Kisfaludi-Bak, Sándor, Nederlof, Jesper, and Węgrzycki, Karol
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Computer Science - Computational Geometry ,Computer Science - Computational Complexity ,Computer Science - Data Structures and Algorithms - Abstract
We revisit the classic task of finding the shortest tour of $n$ points in $d$-dimensional Euclidean space, for any fixed constant $d \geq 2$. We determine the optimal dependence on $\varepsilon$ in the running time of an algorithm that computes a $(1+\varepsilon)$-approximate tour, under a plausible assumption. Specifically, we give an algorithm that runs in $2^{\mathcal{O}(1/\varepsilon^{d-1})} n\log n$ time. This improves the previously smallest dependence on $\varepsilon$ in the running time $(1/\varepsilon)^{\mathcal{O}(1/\varepsilon^{d-1})}n \log n$ of the algorithm by Rao and Smith~(STOC 1998). We also show that a $2^{o(1/\varepsilon^{d-1})}\text{poly}(n)$ algorithm would violate the Gap-Exponential Time Hypothesis (Gap-ETH). Our new algorithm builds upon the celebrated quadtree-based methods initially proposed by Arora (J. ACM 1998), but it adds a new idea that we call \emph{sparsity-sensitive patching}. On a high level this lets the granularity with which we simplify the tour depend on how sparse it is locally. We demonstrate that our technique extends to other problems, by showing that for Steiner Tree and Rectilinear Steiner Tree it yields the same running time. We complement our results with a matching Gap-ETH lower bound for Rectilinear Steiner Tree., Comment: 50 pages, 7 colored figures
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- 2020
40. Tight Lower Bounds for Problems Parameterized by Rank-Width.
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Benjamin Bergougnoux, Tuukka Korhonen, and Jesper Nederlof
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- 2023
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41. A Fine-Grained Classification of the Complexity of Evaluating the Tutte Polynomial on Integer Points Parameterized by Treewidth and Cutwidth.
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Isja Mannens and Jesper Nederlof
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- 2023
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42. Polynomial-Time Approximation of Independent Set Parameterized by Treewidth.
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Parinya Chalermsook, Fedor V. Fomin, Thekla Hamm, Tuukka Korhonen, Jesper Nederlof, and Ly Orgo
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- 2023
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43. Identifying the BRCA1 c.-107A > T variant in Dutch patients with a tumor BRCA1 promoter hypermethylation
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de Jong, Vincent M. T., Pruntel, Roelof, Steenbruggen, Tessa G., Bleeker, Fonnet E., Nederlof, Petra, Hogervorst, Frans B. L., and linn, Sabine C.
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- 2023
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44. Improving Schroeppel and Shamir's Algorithm for Subset Sum via Orthogonal Vectors
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Nederlof, Jesper and Węgrzycki, Karol
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Computer Science - Data Structures and Algorithms ,Computer Science - Computational Complexity - Abstract
We present an $\mathcal{O}^\star(2^{0.5n})$ time and $\mathcal{O}^\star(2^{0.249999n})$ space randomized algorithm for solving worst-case Subset Sum instances with $n$ integers. This is the first improvement over the long-standing $\mathcal{O}^\star(2^{n/2})$ time and $\mathcal{O}^\star(2^{n/4})$ space algorithm due to Schroeppel and Shamir (FOCS 1979). We breach this gap in two steps: (1) We present a space efficient reduction to the Orthogonal Vectors Problem (OV), one of the most central problem in Fine-Grained Complexity. The reduction is established via an intricate combination of the method of Schroeppel and Shamir, and the representation technique introduced by Howgrave-Graham and Joux (EUROCRYPT 2010) for designing Subset Sum algorithms for the average case regime. (2) We provide an algorithm for OV that detects an orthogonal pair among $N$ given vectors in $\{0,1\}^d$ with support size $d/4$ in time $\tilde{O}(N\cdot2^d/\binom{d}{d/4})$. Our algorithm for OV is based on and refines the representative families framework developed by Fomin, Lokshtanov, Panolan and Saurabh (J. ACM 2016). Our reduction uncovers a curious tight relation between Subset Sum and OV, because any improvement of our algorithm for OV would imply an improvement over the runtime of Schroeppel and Shamir, which is also a long standing open problem., Comment: STOC 2021, 38 pages, 3 figures
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- 2020
45. A Faster Exponential Time Algorithm for Bin Packing With a Constant Number of Bins via Additive Combinatorics
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Nederlof, Jesper, Pawlewicz, Jakub, Swennenhuis, Céline M. F., and Węgrzycki, Karol
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Computer Science - Data Structures and Algorithms ,68Q25 ,F.2 - Abstract
In the Bin Packing problem one is given $n$ items with weights $w_1,\ldots,w_n$ and $m$ bins with capacities $c_1,\ldots,c_m$. The goal is to find a partition of the items into sets $S_1,\ldots,S_m$ such that $w(S_j) \leq c_j$ for every bin $j$, where $w(X)$ denotes $\sum_{i \in X}w_i$. Bj\"orklund, Husfeldt and Koivisto (SICOMP 2009) presented an $\mathcal{O}^\star(2^n)$ time algorithm for Bin Packing. In this paper, we show that for every $m \in \mathbf{N}$ there exists a constant $\sigma_m >0$ such that an instance of Bin Packing with $m$ bins can be solved in $\mathcal{O}(2^{(1-\sigma_m)n})$ randomized time. Before our work, such improved algorithms were not known even for $m$ equals $4$. A key step in our approach is the following new result in Littlewood-Offord theory on the additive combinatorics of subset sums: For every $\delta >0$ there exists an $\varepsilon >0$ such that if $|\{ X\subseteq \{1,\ldots,n \} : w(X)=v \}| \geq 2^{(1-\varepsilon)n}$ for some $v$ then $|\{ w(X): X \subseteq \{1,\ldots,n\} \}|\leq 2^{\delta n}$., Comment: SODA 2021; 45 pages; 4 figures
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- 2020
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46. Measurement of jet-medium interactions via direct photon-hadron correlations in Au$+$Au and $d$$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV
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Acharya, U., Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Bataineh, H., Alexander, J., Al-Ta'ani, H., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Bannier, B., Barish, K. N., Bassalleck, B., Basye, A. T., Bathe, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bhom, J. H., Bichon, L., Bickley, A. A., Black, D., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Camacho, C. M., Campbell, S., Roman, V. Canoa, Caringi, A., Castera, P., Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chung, P., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., del Valle, Z. Conesa, Connors, M., Constantin, P., Cronin, N., Crossette, N., Csanád, M., Csörgő, T., Dahms, T., Dairaku, S., Danchev, I., Das, K., Datta, A., Daugherity, M. S., David, G., Dayananda, M. K., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Do, J. H., Donadelli, M., D'Orazio, L., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Dutta, D., Edwards, S., Efremenko, Y. V., Ellinghaus, F., Engelmore, T., Enokizono, A., En'yo, H., Esha, R., Esumi, S., Eyser, K. O., Fadem, B., Fan, W., Fields, D. E., Finger, M., Finger, Jr., M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garg, P., Garishvili, A., Garishvili, I., Giordano, F., Glenn, A., Gong, H., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Grim, G., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamblen, J., Han, R., Han, S. Y., Hanks, J., Hartouni, E. P., Hasegawa, S., Hashimoto, K., Haslum, E., Hayano, R., Hayashi, S., He, X., Heffner, M., Hemmick, T. K., Hester, T., Hill, J. C., Hodges, A., Hohlmann, M., Hollis, R. S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Hornback, D., Huang, J., Huang, S., Ichihara, T., Ichimiya, R., Ide, J., Iinuma, H., Ikeda, Y., Imai, K., Imazu, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Ishihara, M., Isinhue, A., Isobe, T., Issah, M., Isupov, A., Ivanishchev, D., Iwanaga, Y., Jacak, B. V., Javani, M., Ji, Z., Jia, J., Jiang, X., Jin, J., Johnson, B. M., Jones, T., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kawashima, M., Kazantsev, A. V., Kempel, T., Key, J. A., Khachatryan, V., Khandai, P. K., Khanzadeev, A., Khatiwada, A., Kijima, K. M., Kikuchi, J., Kim, A., Kim, B. I., Kim, C., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, S. H., Kim, Y. -J., Kim, Y. K., Kincses, D., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Kochenda, L., Komatsu, Y., Komkov, B., Konno, M., Koster, J., Kotchetkov, D., Kotov, D., Kozlov, A., Král, A., Kravitz, A., Krizek, F., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Larionova, D., Larionova, M., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Leitner, E., Lenzi, B., Lewis, B., Lewis, N. A., Li, X., Lichtenwalner, P., Liebing, P., Lim, S. H., Levy, L. A. Linden, Liška, T., Litvinenko, A., Liu, H., Liu, M. X., Lökös, S., Love, B., Luechtenborg, R., Lynch, D., Maguire, C. F., Majoros, T., Makdisi, Y. I., Makek, M., Malakhov, A., Malik, M. D., Manion, A., Manko, V. I., Mannel, E., Mao, Y., Masui, H., Masumoto, S., Matathias, F., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Means, N., Meles, A., Mendoza, M., Meredith, B., Metzger, W. J., Miake, Y., Mibe, T., Midori, J., Mignerey, A. C., Mikeš, P., Miki, K., Milov, A., Mishra, D. K., Mishra, M., Mitchell, J. T., Mitrankov, Iu., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Mohapatra, S., Moon, H. J., Moon, T., Morino, Y., Morreale, A., Morrison, D. P., Morrow, S. I., Moskowitz, M., Motschwiller, S., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nam, S., Nattrass, C., Nederlof, A., Nelson, S., Netrakanti, P. K., Newby, J., Nguyen, M., Nihashi, M., Niida, T., Nouicer, R., Novitzky, N., Nukariya, A., Nyanin, A. S., Oakley, C., Obayashi, H., O'Brien, E., Oda, S. X., Ogilvie, C. A., Oka, M., Okada, K., Onuki, Y., Osborn, J. D., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J., Park, S., Park, S. K., Park, W. J., Pate, S. F., Patel, L., Patel, M., Pei, H., Peng, J. -C., Peng, W., Pereira, H., Perepelitsa, D. V., Peresedov, V., Peressounko, D. Yu., PerezLara, C. E., Petti, R., Pinkenburg, C., Pisani, R. P., Proissl, M., Pun, A., Purschke, M. L., Purwar, A. K., Qu, H., Radzevich, P. V., Rak, J., Rakotozafindrabe, A., Ramasubramanian, N., Ravinovich, I., Read, K. F., Rembeczki, S., Reygers, K., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Rinn, T., Riveli, N., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Rosen, C. A., Rosendahl, S. S. E., Rosnet, P., Rukoyatkin, P., Runchey, J., Ružička, P., Ryu, M. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakashita, K., Sako, H., Samsonov, V., Sano, M., Sano, S., Sarsour, M., Sato, S., Sato, T., Sawada, S., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Sen, A., Seto, R., Sett, P., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Skolnik, M., Slunečka, M., Smith, K. L., Solano, S., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Sparks, N. A., Stankus, P. W., Steinberg, P., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sun, X., Sun, Z., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanabe, R., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Tennant, E., Themann, H., Thomas, D., Thomas, T. L., Todoroki, T., Togawa, M., Toia, A., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Ueda, Y., Ujvari, B., Vale, C., Valle, H., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Vinogradov, A. A., Virius, M., Voas, B., Vossen, A., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., Wessels, J., Whitaker, S., White, S. N., Winter, D., Wolin, S., Wong, C. P., Wood, J. P., Woody, C. L., Wright, R. M., Wu, Y., Wysocki, M., Xia, B., Xie, W., Xu, Q., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Yoon, I., You, Z., Young, G. R., Younus, I., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zhai, Y., Zhang, C., Zharko, S., Zhou, S., Zolin, L., and Zou, L.
- Subjects
High Energy Physics - Experiment ,Nuclear Experiment - Abstract
We present direct photon-hadron correlations in 200 GeV/A Au$+$Au, $d$$+$Au and $p$$+$$p$ collisions, for direct photon $p_T$ from 5--12 GeV/$c$, collected by the PHENIX Collaboration in the years from 2006 to 2011. We observe no significant modification of jet fragmentation in $d$$+$Au collisions, indicating that cold nuclear matter effects are small or absent. Hadrons carrying a large fraction of the quark's momentum are suppressed in Au$+$Au compared to $p$$+$$p$ and $d$$+$Au. As the momentum fraction decreases, the yield of hadrons in Au$+$Au increases to an excess over the yield in $p$$+$$p$ collisions. The excess is at large angles and at low hadron $p_T$ and is most pronounced for hadrons associated with lower momentum direct photons. Comparison to theoretical calculations suggests that the hadron excess arises from medium response to energy deposited by jets., Comment: 578 authors from 80 institutions, 11 pages, 7 figures, data from 2007, 2008, 2010, and 2011. v2 is version accepted for publication in Physical Review C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html
- Published
- 2020
- Full Text
- View/download PDF
47. Hamiltonian Cycle Parameterized by Treedepth in Single Exponential Time and Polynomial Space
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Nederlof, Jesper, Pilipczuk, Michał, Swennenhuis, Céline M. F., and Węgrzycki, Karol
- Subjects
Computer Science - Data Structures and Algorithms ,68Q25 ,F.2 - Abstract
For many algorithmic problems on graphs of treewidth $t$, a standard dynamic programming approach gives an algorithm with time and space complexity $2^{\mathcal{O}(t)}\cdot n^{\mathcal{O}(1)}$. It turns out that when one considers the more restrictive parameter treedepth, it is often the case that a variation of this technique can be used to reduce the space complexity to polynomial, while retaining time complexity of the form $2^{\mathcal{O}(d)}\cdot n^{\mathcal{O}(1)}$, where $d$ is the treedepth. This transfer of methodology is, however, far from automatic. For instance, for problems with connectivity constraints, standard dynamic programming techniques give algorithms with time and space complexity $2^{\mathcal{O}(t\log t)}\cdot n^{\mathcal{O}(1)}$ on graphs of treewidth $t$, but it is not clear how to convert them into time-efficient polynomial space algorithms for graphs of low treedepth. Cygan et al. (FOCS'11) introduced the Cut&Count technique and showed that a certain class of problems with connectivity constraints can be solved in time and space complexity $2^{\mathcal{O}(t)}\cdot n^{\mathcal{O}(1)}$. Recently, Hegerfeld and Kratsch (STACS'20) showed that, for some of those problems, the Cut&Count technique can be also applied in the setting of treedepth, and it gives algorithms with running time $2^{\mathcal{O}(d)}\cdot n^{\mathcal{O}(1)}$ and polynomial space usage. However, a number of important problems eluded such a treatment, with the most prominent examples being Hamiltonian Cycle and Longest Path. In this paper we clarify the situation by showing that Hamiltonian Cycle, Hamiltonian Path, Long Cycle, Long Path, and Min Cycle Cover all admit $5^d\cdot n^{\mathcal{O}(1)}$-time and polynomial space algorithms on graphs of treedepth $d$. The algorithms are randomized Monte Carlo with only false negatives., Comment: Presented at WG2020. 20 pages, 2 figures
- Published
- 2020
48. Effect of different types of bacterial single cell protein on feed intake, digestibility, growth and body composition of Pacific white shrimp (Penaeus vannamei)
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Marit A.J. Nederlof, Sachi J. Kaushik, and Johan W. Schrama
- Subjects
Novel ingredients ,Bacterial meal ,Fishmeal replacement/alternative ,Methanotrophs ,Protein source ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
This study assessed the potential of four bacterial (Methylococcus capsulatus) single cell protein (SCP) products as alternative protein sources for Pacific white shrimp (Penaeus vannamei) diets. A growth trial and a digestibility trial were undertaken, during which the bacterial SCP products were compared with a high-quality fishmeal and a soy protein concentrate, regarding their impact on ingredient digestibility, growth, feed intake and whole-body composition of juvenile P. vannamei. Seven diets were formulated; one reference diet (REF) and six test diets. The test diets consisted of 85% of the REF diet and 15% of a test ingredient. Ingredients tested were four bacterial SCP products (SCP1–4), which differed in processing conditions, fishmeal (FM) and soy protein concentrate (SoyProt). Growth and feed utilization were similar for P. vannamei fed either the FM diet or one of the bacterial SCP diets, whilst lowest growth and feed utilization were observed for shrimp fed the SoyProt diet. Final whole-body protein content did not differ between shrimp fed the FM diet or one of the four bacterial SCP diets. However, shrimp fed the SCP diets had a significantly higher final phosphorus body content and a higher phosphorus retention than shrimp fed the FM or SoyProt diets. This indicates a higher phosphorus availability in the bacterial SCP products compared to FM and SoyProt. Protein digestibility of the SCP products was similar to FM, whilst amino acid (AA) digestibility was comparable to FM for three of the four SCP products (SCP1, SCP2 and SCP4). The SCP3 product showed the lowest digestibility for most AA, indicating a possible influence of processing conditions on AA availability of bacterial SCPs. Overall, this study highlights that bacterial SCP originating from M. capsulatus is a viable alternative protein source for Pacific white shrimp diets, but processing conditions should be taken into account.
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- 2023
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49. Parameterized Complexity of Partial Scheduling
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Nederlof, Jesper and Swennenhuis, Céline
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Computer Science - Data Structures and Algorithms ,68Q25 ,F.2 - Abstract
We study a natural variant of scheduling that we call \emph{partial scheduling}: In this variant an instance of a scheduling problem along with an integer $k$ is given and one seeks an optimal schedule where not all, but only $k$ jobs, have to be processed. Specifically, we aim to determine the fine-grained parameterized complexity of partial scheduling problems parameterized by $k$ for all variants of scheduling problems that minimize the makespan and involve unit/arbitrary processing times, identical/unrelated parallel machines, release/due dates, and precedence constraints. That is, we investigate whether algorithms with runtimes of the type $f(k)n^{\mathcal{O}(1)}$ or $n^{\mathcal{O}(f(k))}$ exist for a function $f$ that is as small as possible. Our contribution is two-fold: First, we categorize each variant to be either in $\mathsf{P}$, $\mathsf{NP}$-complete and fixed-parameter tractable by $k$, or $\mathsf{W}[1]$-hard parameterized by $k$. Second, for many interesting cases we further investigate the run time on a finer scale and obtain run times that are (almost) optimal assuming the Exponential Time Hypothesis. As one of our main technical contributions, we give an $\mathcal{O}(8^kk(|V|+|E|))$ time algorithm to solve instances of partial scheduling problems minimizing the makespan with unit length jobs, precedence constraints and release dates, where $G=(V,E)$ is the graph with precedence constraints., Comment: 22 pages, 3 figues. Updated version
- Published
- 2019
50. Effect of different types of bacterial single cell protein on feed intake, digestibility, growth and body composition of Pacific white shrimp (Penaeus vannamei)
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Nederlof, Marit A.J., Kaushik, Sachi J., and Schrama, Johan W.
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- 2023
- Full Text
- View/download PDF
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