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1. ROS1 fusions in resected stage I-III adenocarcinoma: Results from the European Thoracic Oncology Platform Lungscape project

Author

Speel, Ernst-Jan M., Dafni, Urania, Thunnissen, Erik, Hendrik Rüschoff, Jan, O'Brien, Cathal, Kowalski, Jacek, Kerr, Keith M., Bubendorf, Lukas, Sansano, Irene, Joseph, Leena, Kriegsmann, Mark, Navarro, Atilio, Monkhorst, Kim, Bille Madsen, Line, Hernandez Losa, Javier, Biernat, Wojciech, Stenzinger, Albrecht, Rüland, Andrea, Hillen, Lisa M., Marti, Nesa, Molina-Vila, Miguel A., Dellaporta, Tereza, Kammler, Roswitha, Peters, Solange, Stahel, Rolf A., Finn, Stephen P., and Radonic, Teodora

Published
2024
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2. Programmed death-ligand 1 expression influenced by tissue sample size. Scoring based on tissue microarrays' and cross-validation with resections, in patients with, stage I–III, non-small cell lung carcinoma of the European Thoracic Oncology Platform Lungscape cohort

Author

Thunnissen, Erik, Kerr, Keith M., Dafni, Urania, Bubendorf, Lukas, Finn, Stephen P., Soltermann, Alex, Biernat, Wojciech, Cheney, Richard, Verbeken, Erik, Warth, Arne, Marchetti, Antonio, Speel, Ernst-Jan M., Pokharel, Saraswati, Quinn, Anne Marie, Monkhorst, Kim, Navarro, Atilio, Madsen, Line Bille, Tsourti, Zoi, Geiger, Thomas, Kammler, Roswitha, Peters, Solange, Stahel, Rolf A., Rosell, Rafael, Blackhall, Fiona, Molina, Miguel Angel, Weder, Walter, Finn, Stephen, Hiltbrunner, Anita, Marti, Nesa, Polydoropoulou, Varvara, Zygoura, Panagiota, Nicolson, Marianne, Stevenson, David A.J, Mathieson, William, Smit, Egbert, Radonic, Teodora, Rulle, Undine, Curioni, Alessandra, Gray, Steven G., Gately, Kathy, Barr, Martin, Meldgaard, Peter, Madsen, Line B., Savic, Spasenija, Lardinois, Didier, Nackaerts, Kristiaan, Dooms, Christophe, Wauters, Els, Van Der Borght, Sara, Wrona, Ania, Rzyman, Witold, Jassem, Jacek, Dienemann, Hendrik, Muley, Thomas, De Luca, Graziano, di Lorito, Alessia, Dingemans, Anne-Marie, Ruland, Andrea, Ferenczy, Philip, Franklin, Lynsey, Baas, Paul, van de Wiel, Bart, Camps, Carlos, and Martorell, Miguel

Published
2020
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3. Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry — Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort

Author

Rulle, Undine, Tsourti, Zoi, Casanova, Ruben, Deml, Karl-Friedrich, Verbeken, Eric, Thunnissen, Erik, Warth, Arne, Cheney, Richard, Sejda, Aleksandra, Speel, Ernst Jan, Madsen, Line Bille, Nonaka, Daisuke, Navarro, Atilio, Sansano, Irene, Marchetti, Antonio, Finn, Stephen P., Monkhorst, Kim, Kerr, Keith M., Haberecker, Martina, Wu, Chengguang, Zygoura, Panagiota, Kammler, Roswitha, Geiger, Thomas, Gendreau, Steven, Schulze, Katja, Vrugt, Bart, Wild, Peter, Moch, Holger, Weder, Walter, Ciftlik, Ata Tuna, Dafni, Urania, Peters, Solange, Bubendorf, Lukas, Stahel, Rolf A., and Soltermann, Alex

Published
2018
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4. Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project

Author

Stahel, Rolf A., Rosell, Rafael, Blackhall, Fiona, Dafni, Urania, Kerr, Keith M., Molina, Miguel Ángel, Bubendorf, Lukas, Weder, Walter, Thunnissen, Erik, Peters, Solange, Finn, Stephen, Hiltbrunner, Anita, Kammler, Roswitha, Geiger, Thomas, Marti, Nesa, Tsourti, Zoi, Polydoropoulou, Varvara, Zygoura, Panagiota, Smyth, Paul, O’Brien, Cathal, Gray, Steven, Soltermann, Alex, Opitz, Isabelle, Curioni, Alessandra, Savic, Spasenija, Lardinois, Didier, Dingemans, Anne-Marie, Speel, Ernst-Jan M., Ruland, Andrea, Marchetti, Antonio, Di Lorito, Alessia, De Luca, Graziano, Malatesta, Sara, Nonaka, Daisuke, Quinn, Anne Marie, Franklin, Lynsey, Biernat, Wojciech, Wrona, Ania, Rzyman, Witold, Jassem, Jacek, Meldgaard, Peter, Hager, Henrik, Madsen, Line B., Camps, Carlos, Martorell, Miguel, Jantus-Lewintre, Eloisa, Guijarro, Ricardo, Nicolson, Marianne, Stevenson, David A.J., Mathieson, William, Baas, Paul, de Jong, Jeroen, Monkhorst, Kim, Smit, Egbert, van Setten, Coralien, de Langen, Joop, Felip, Enriqueta, Hernandez-Losa, Javier, Sansano, Irene, Cheney, Richard, Pine, Mary Beth, Reid, Mary, Taylor, Elizabeth, Nackaerts, Kristiaan, Dooms, Christophe, Wauters, Els, Van Der Borght, Sara, Dienemann, Hendrik, Muley, Thomas, Warth, Arne, Letovanec, Igor, Speel, Ernst-Jan, Sejda, Aleksandra, Verbeken, Eric, Navarro, Atilio, Dziadziuszko, Rafal, Vansteenkiste, Johan, O'Brien, Cathal, Sherlock, Jon, Schageman, Jeoffrey, Kerr, Keith, and Stahel, Rolf

Published
2018
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6. Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project

Author

Letovanec, Igor, Finn, Stephen, Zygoura, Panagiota, Smyth, Paul, Soltermann, Alex, Bubendorf, Lukas, Speel, Ernst-Jan, Marchetti, Antonio, Nonaka, Daisuke, Monkhorst, Kim, Hager, Henrik, Martorell, Miguel, Sejda, Aleksandra, Cheney, Richard, Hernandez-Losa, Javier, Verbeken, Eric, Weder, Walter, Savic, Spasenija, Di Lorito, Alessia, Navarro, Atilio, Felip, Enriqueta, Warth, Arne, Baas, Paul, Meldgaard, Peter, Blackhall, Fiona, Dingemans, Anne-Marie, Dienemann, Hendrik, Dziadziuszko, Rafal, Vansteenkiste, Johan, OʼBrien, Cathal, Geiger, Thomas, Sherlock, Jon, Schageman, Jeoffrey, Dafni, Urania, Kammler, Roswitha, Kerr, Keith, Thunnissen, Erik, Stahel, Rolf, Peters, Solange, Stahel, Rolf A., Rosell, Rafael, Blackhall, Fiona, Dafni, Urania, Kerr, Keith M., Molina, Miguel Ángel, Bubendorf, Lukas, Weder, Walter, Thunnissen, Erik, Peters, Solange, Finn, Stephen, Hiltbrunner, Anita, Kammler, Roswitha, Geiger, Thomas, Marti, Nesa, Tsourti, Zoi, Polydoropoulou, Varvara, Zygoura, Panagiota, Smyth, Paul, O’Brien, Cathal, Gray, Steven, Soltermann, Alex, Opitz, Isabelle, Curioni, Alessandra, Savic, Spasenija, Lardinois, Didier, Dingemans, Anne-Marie, Speel, Ernst-Jan M., Ruland, Andrea, Marchetti, Antonio, Di Lorito, Alessia, De Luca, Graziano, Malatesta, Sara, Nonaka, Daisuke, Quinn, Anne Marie, Franklin, Lynsey, Biernat, Wojciech, Wrona, Ania, Rzyman, Witold, Jassem, Jacek, Meldgaard, Peter, Hager, Henrik, Madsen, Line B., Camps, Carlos, Martorell, Miguel, Jantus-Lewintre, Eloisa, Guijarro, Ricardo, Nicolson, Marianne, Stevenson, David A.J., Mathieson, William, Baas, Paul, de Jong, Jeroen, Monkhorst, Kim, Smit, Egbert, van Setten, Coralien, de Langen, Joop, Felip, Enriqueta, Hernandez-Losa, Javier, Sansano, Irene, Cheney, Richard, Pine, Mary Beth, Reid, Mary, Taylor, Elizabeth, Nackaerts, Kristiaan, Dooms, Christophe, Wauters, Els, Van Der Borght, Sara, Dienemann, Hendrik, Muley, Thomas, and Warth, Arne

Published
2018
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7. A retrospective cohort study of PD-L1 prevalence, molecular associations and clinical outcomes in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape Project

Author

Kerr, Keith M, Thunnissen, Erik, Dafni, Urania, Finn, Stephen P, Bubendorf, Lukas, Soltermann, Alex, Verbeken, Eric, Biernat, Wojciech, Warth, Arne, Marchetti, Antonio, Speel, Ernst-Jan M, Pokharel, Sarawati, Quinn, Anne Marie, Monkhorst, Kim, Navarro, Atilio, Madsen, Line Bille, Radonic, Teodora, Wilson, Joan, De Luca, Graziano, Gray, Steven G, Cheney, Richard, Savic, Spasenija, Martorell, Miguel, Muley, Thomas, Baas, Paul, Meldgaard, Peter, Blackhall, Fiona, Dingemans, Anne-Marie, Dziadziuszko, Rafal, Vansteenkiste, Johan, Weder, Walter, Stahel, Rrolf, et al, University of Zurich, and Kerr, Keith M

Subjects
10255 Clinic for Thoracic Surgery, 2740 Pulmonary and Respiratory Medicine, 10049 Institute of Pathology and Molecular Pathology, 10032 Clinic for Oncology and Hematology, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research
Published
2019

8. Computer-based intensity measurement assists pathologists in scoring PTEN immunohistochemistry - Clinical associations in NSCLC patients of the ETOP Lungscape cohort

Author

Rulle, Undine, Tsourti, Zoi, Casanova, Ruben, Deml, Karl-Friedrich, Verbeken, Eric, Thunnissen, Erik, Warth, Arne, Cheney, Richard, Sejda, Aleksandra, Speel, Ernst Jan, Madsen, Line Bille, Nonaka, Daisuke, Navarro, Atilio, Sansano, Irene, Marchetti, Antonio, Finn, Stephen P, Monkhorst, Kim, Kerr, Keith M, Haberecker, Martina, Wu, Chengguang, Zygoura, Panagiota, Kammler, Roswitha, Geiger, Thomas, Gendreau, Steven, Schulze, Katja, Vrugt, Bart, Wild, Peter, Moch, Holger, Weder, Walter, Ciftlik, Ata Tuna, Dafni, Urania, Peters, Solange, Bubendorf, Lukas, Stahel, Rolf A, Soltermann, Alex, University of Zurich, and Soltermann, Alex

Subjects
10255 Clinic for Thoracic Surgery, 2740 Pulmonary and Respiratory Medicine, 10049 Institute of Pathology and Molecular Pathology, 10032 Clinic for Oncology and Hematology, 610 Medicine & health, 2730 Oncology
Published
2018

9. A retrospective cohort study of PD-L1 prevalence, molecular associations and clinical outcomes in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape Project

Author

Kerr, Keith M, Thunnissen, Erik, Dafni, Urania, Finn, Stephen P, Bubendorf, Lukas, Soltemiann, Alex, Verbeken, Eric, Biernat, Wojciech, Warth, Arne, Marchetti, Antonio, Speel, Ernst-Jan M, Pokharel, Sarawati, Quinn, Anne Marie, Monlchorst, Kim, Navarro, Atilio, Madsen, Line Bille, Radonic, Teodora, Wilson, Joan, De Luca, Graziano, Gray, Steven G, Cheney, Richard, Savic, Spasenija, Martorell, Miguel, Muley, Thomas, Baas, Paul, Meldgaard, Peter, Blackhall, Fiona, Dingemans, Anne-Marie, Dziadziuszko, Rafal, Vansteenkiste, Johan, Weder, Walter, Polydoropoulou, Varvara, Geiger, Thomas, Kammler, Roswitha, Peters, Solange, Stahel, Rolf, Rosell, Rafael, Molina, Miguel Angel, Hiltbrunner, Anita, Marti, Nesa, Tsourti, Zoi, Zygoura, Panagiota, Nicolson, Marianne, Stevenson, David AJ, Mathieson, William, Smit, Egbert, van Setten, Coralien, Soltermann, Alex, Rulle, Undine, Curioni, Alessandra, Mc Fadden, Julie, Cuffe, Sinead, Lardinois, Didier, Nackaerts, Kristiaan, Dooms, Christophe, Wauters, Els, Van Der Borght, Sara, Wrona, Ania, Rzyman, Witold, Jassem, Jacek, Dienemann, Hendrik, di Lorito, Alessia, Ruland, Andrea, Ferenczy, Philip, Franklin, Lynsey, Monkhorst, Kim, van de Wiel, Bart, Camps, Carlos, Pathologie, RS: GROW - R2 - Basic and Translational Cancer Biology, Pulmonologie, MUMC+: MA Med Staf Spec Longziekten (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Pathology, and CCA - Cancer Treatment and quality of life

Subjects
0301 basic medicine, Oncology, Male, Cancer Research, DEATH-LIGAND 1, Lung Neoplasms, CLINICOPATHOLOGICAL ANALYSIS, B7-H1 Antigen, Cohort Studies, 0302 clinical medicine, Non-small cell lung cancer, Carcinoma, Non-Small-Cell Lung, PROGNOSTIC-SIGNIFICANCE, Medicine, Stage (cooking), Aged, 80 and over, Tissue microarray, Middle Aged, Proto-Oncogene Proteins c-met, Prognosis, Europe, Treatment Outcome, 030220 oncology & carcinogenesis, Cohort, Biomarker (medicine), Immunohistochemistry, Adenocarcinoma, Immunotherapy, Pulmonary and Respiratory Medicine, EXPRESSION, PD-L1, Adult, medicine.medical_specialty, CELL LUNG-CANCER, Adenocarcinoma of Lung, 03 medical and health sciences, Young Adult, Internal medicine, Biomarkers, Tumor, Humans, Aged, Neoplasm Staging, Retrospective Studies, business.industry, MUTATIONS, Retrospective cohort study, ADENOCARCINOMA, AMPLIFICATION, medicine.disease, Survival Analysis, 030104 developmental biology, Neoplastic cell, OVEREXPRESSION, business, INHIBITORS, Follow-Up Studies
Abstract

INTRODUCTION: The PD-L1 biomarker is an important factor in selecting patients with non-small cell lung cancer for immunotherapy. While several reports suggest that PD-L1 positivity is linked to a poor prognosis, others suggest that PD-L1 positive status portends a good prognosis. METHODS: PD-L1 positivity prevalence, assessed via immunohistochemistry (IHC) on tissue microarrays (TMAs), and its association with clinicopathological characteristics, molecular profiles and patient outcome- Relapse-free Survival (RFS), Time-to-Relapse (TTR) and Overall Survival (OS)- is explored in the ETOP Lungscape cohort of stage I-III non-small cell lung cancer (NSCLC). Tumors are considered positive if they have ≥1/5/25/50% neoplastic cell membrane staining. RESULTS: PD-L1 expression was assessed in 2182 NSCLC cases (2008 evaluable, median follow-up 4.8 years, 54.6% still alive), from 15 ETOP centers. Adenocarcinomas represent 50.9% of the cohort (squamous cell: 42.4%). Former smokers are 53.7% (current: 31.6%, never: 10.5%). PD-L1 positivity prevalence is present in more than one third of the Lungscape cohort (1%/5% cut-offs). It doesn't differ between adenocarcinomas and squamous cell histologies, but is more frequently detected in higher stages, never smokers, larger tumors (1/5/25% cut-offs). With ≥1% cut-off it is significantly associated with IHC MET overexpression, expression of PTEN, EGFR and KRAS mutation (only for adenocarcinoma). Results for 5%, 25% and 50% cut-offs were similar, with MET being significantly associated with PD-L1 positivity both for AC (p

Published
2018

10. Evaluation of NGS and RT-PCR methods for ALK rearrangement in European NSCLC patients:Results from the ETOP Lungscape Project

Author

Letovanec, Igor, Finn, Stephen, Zygoura, Panagiota, Smyth, Paul, Soltermann, Alex, Bubendorf, Lukas, Speel, Ernst-Jan, Marchetti, Antonio, Nonaka, Daisuke, Monkhorst, Kim, Hager, Henrik, Martorell, Miguel, Sejda, Aleksandra, Cheney, Richard, Hernandez-Losa, Javier, Verbeken, Eric, Weder, Walter, Savic, Spasenija, Di Lorito, Alessia, Navarro, Atilio, Felip, Enriqueta, Warth, Arne, Baas, Paul, Meldgaard, Peter, Blackhall, Fiona, Dingemans, Anne-Marie, Dienemann, Hendrik, Dziadziuszko, Rafal, Vansteenkiste, Johan, O'Brien, Cathal, Geiger, Thomas, Sherlock, Jon, Schageman, Jeoffrey, Dafni, Urania, Kammler, Roswitha, Kerr, Keith, Thunnissen, Erik, Stahel, Rolf, and Peters, Solange

Subjects
hemic and lymphatic diseases, Journal Article
Abstract

INTRODUCTION: The reported prevalence of ALK rearrangement in NSCLC ranges from 2%-7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proven to be a reproducible and sensitive technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) has also been advocated and most recently the advent of targeted Next-Generation Sequencing (NGS) for ALK and other fusions has become possible. This study compares ALK evaluation with all 4 techniques in resected NSCLC from the large ETOP Lungscape cohort. METHODS: 96 cases from the ETOP Lungscape iBiobank, with any ALK immunoreactivity were examined by FISH, central RT-PCR and NGS. H-score>120 defines IHC-positivity. RNA was extracted from the same formalin-fixed, paraffin-embedded tissues. For RT-PCR, primers covered the most frequent ALK translocations. For NGS, the Oncomine™ Solid Tumour Fusion Transcript Kit was used. The concordance was assessed using the Cohen's kappa coefficient (two-sided alpha≤5%). RESULTS: NGS provided results for 77 out of the 95 cases tested (81.1%), while RT-PCR for 77 out of 96 (80.2%). Concordance occurred in 55 cases out of the 60 cases tested with all 4 methods (43 ALK-negative, 12 ALK-positive). Using ALK co-positivity for IHC and FISH as gold standard, we derive sensitivity for RT-PCR/NGS 70.0%/85.0%, with specificity 87.1%/79.0%. Combining either RT-PCR or NGS with IHC, the sensitivity remains the same, while the specificity increases to 88.7% and 83.9% respectively. CONCLUSION: NGS evaluation with the Oncomine™ Solid Tumour Fusion transcript kit and RT-PCR proves to have high sensitivity and specificity advocating their use in routine practice. For maximal sensitivity and specificity, ALK status should be assessed using two techniques and a third one in discordant cases. We therefore propose a customizable testing algorithm. These findings significantly influence existing testing paradigms and have clear clinical and economic impact.

Published
2018

11. A retrospective cohort study of PD-L1 prevalence, molecular associations and clinical outcomes in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape Project

Author

Kerr, Keith M., primary, Thunnissen, Erik, additional, Dafni, Urania, additional, Finn, Stephen P., additional, Bubendorf, Lukas, additional, Soltermann, Alex, additional, Verbeken, Eric, additional, Biernat, Wojciech, additional, Warth, Arne, additional, Marchetti, Antonio, additional, Speel, Ernst-Jan M., additional, Pokharel, Sarawati, additional, Quinn, Anne Marie, additional, Monkhorst, Kim, additional, Navarro, Atilio, additional, Madsen, Line Bille, additional, Radonic, Teodora, additional, Wilson, Joan, additional, De Luca, Graziano, additional, Gray, Steven G., additional, Cheney, Richard, additional, Savic, Spasenija, additional, Martorell, Miguel, additional, Muley, Thomas, additional, Baas, Paul, additional, Meldgaard, Peter, additional, Blackhall, Fiona, additional, Dingemans, Anne-Marie, additional, Dziadziuszko, Rafal, additional, Vansteenkiste, Johan, additional, Weder, Walter, additional, Polydoropoulou, Varvara, additional, Geiger, Thomas, additional, Kammler, Roswitha, additional, Peters, Solange, additional, and Stahel, Rolf, additional

Published
2019
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14. P1.02-025 Evaluation of NGS and RT-PCR Methods for ALK Assessment in European NSCLC Patients: Results from the ETOP Lungscape Project

Author

Finn, Stephen, primary, Letovanec, Igor, additional, Zygoura, Panagiota, additional, Smyth, Paul, additional, Soltermann, Alex, additional, Bubendorf, Lukas, additional, Speel, Ernst-Jan, additional, Marchetti, Antonio, additional, Nonaka, Daisuke, additional, Monkhorst, Kim, additional, Hager, Henrik, additional, Martorell, Miguel, additional, Sejda, Aleksandra, additional, Cheney, Richard, additional, Hernandez-Losa, Javier, additional, Verbeken, Eric, additional, Weder, Walter, additional, Savic, Spasenija, additional, Di Lorito, Alessia, additional, Navarro, Atilio, additional, Felip, Enriqueta, additional, Warth, Arne, additional, Baas, Paul, additional, Meldgaard, Peter, additional, Blackhall, Fiona, additional, Dingemans, Anne-Marie, additional, Dienemann, Hendrik, additional, Dziadziuszko, Rafal, additional, Vansteenkiste, Johan, additional, Geiger, Thomas, additional, Sherlock, Jon, additional, Schageman, Jeoffrey, additional, Dafni, Urania, additional, Kammler, Roswitha, additional, Kerr, Keith, additional, Thunnissen, Erik, additional, Peters, Solange, additional, and Stahel, Rolf, additional

Published
2017
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16. Evaluation of NGS and RT-PCR Methods for ALKRearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project

Author

Letovanec, Igor, Finn, Stephen, Zygoura, Panagiota, Smyth, Paul, Soltermann, Alex, Bubendorf, Lukas, Speel, Ernst-Jan, Marchetti, Antonio, Nonaka, Daisuke, Monkhorst, Kim, Hager, Henrik, Martorell, Miguel, Sejda, Aleksandra, Cheney, Richard, Hernandez-Losa, Javier, Verbeken, Eric, Weder, Walter, Savic, Spasenija, Di Lorito, Alessia, Navarro, Atilio, Felip, Enriqueta, Warth, Arne, Baas, Paul, Meldgaard, Peter, Blackhall, Fiona, Dingemans, Anne-Marie, Dienemann, Hendrik, Dziadziuszko, Rafal, Vansteenkiste, Johan, O'Brien, Cathal, Geiger, Thomas, Sherlock, Jon, Schageman, Jeoffrey, Dafni, Urania, Kammler, Roswitha, Kerr, Keith, Thunnissen, Erik, Stahel, Rolf, Peters, Solange, Stahel, Rolf A., Rosell, Rafael, Blackhall, Fiona, Dafni, Urania, Kerr, Keith M., Molina, Miguel Ángel, Bubendorf, Lukas, Weder, Walter, Thunnissen, Erik, Peters, Solange, Finn, Stephen, Hiltbrunner, Anita, Kammler, Roswitha, Geiger, Thomas, Marti, Nesa, Dafni, Urania, Tsourti, Zoi, Polydoropoulou, Varvara, Zygoura, Panagiota, Finn, Stephen, Smyth, Paul, O’Brien, Cathal, Gray, Steven, Weder, Walter, Soltermann, Alex, Opitz, Isabelle, Curioni, Alessandra, Bubendorf, Lukas, Savic, Spasenija, Lardinois, Didier, Dingemans, Anne-Marie, Speel, Ernst-Jan M., Ruland, Andrea, Marchetti, Antonio, Di Lorito, Alessia, De Luca, Graziano, Malatesta, Sara, Blackhall, Fiona, Nonaka, Daisuke, Quinn, Anne Marie, Franklin, Lynsey, Biernat, Wojciech, Wrona, Ania, Rzyman, Witold, Jassem, Jacek, Meldgaard, Peter, Hager, Henrik, Madsen, Line B., Camps, Carlos, Martorell, Miguel, Jantus-Lewintre, Eloisa, Guijarro, Ricardo, Kerr, Keith M., Nicolson, Marianne, Stevenson, David A.J., Mathieson, William, Baas, Paul, de Jong, Jeroen, Monkhorst, Kim, Thunnissen, Erik, Smit, Egbert, van Setten, Coralien, de Langen, Joop, Felip, Enriqueta, Hernandez-Losa, Javier, Sansano, Irene, Cheney, Richard, Pine, Mary Beth, Reid, Mary, Taylor, Elizabeth, Nackaerts, Kristiaan, Dooms, Christophe, Wauters, Els, Van Der Borght, Sara, Dienemann, Hendrik, Muley, Thomas, and Warth, Arne

Abstract

The reported prevalence of ALK receptor tyrosine kinase gene (ALK) rearrangement in NSCLC ranges from 2% to 7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proved to be a reproducible and sensitive technique. Reverse-transcriptase polymerase chain reaction (RT-PCR) has also been advocated, and most recently, the advent of targeted next-generation sequencing (NGS) for ALKand other fusions has become possible. This study compares anaplastic lymphoma kinase (ALK) evaluation with all four techniques in resected NSCLC from the large European Thoracic Oncology Platform Lungscape cohort.

Published
2018
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