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Evaluation of NGS and RT-PCR Methods for ALKRearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project
- Source :
- Journal of Thoracic Oncology; March 2018, Vol. 13 Issue: 3 p413-425, 13p
- Publication Year :
- 2018
-
Abstract
- The reported prevalence of ALK receptor tyrosine kinase gene (ALK) rearrangement in NSCLC ranges from 2% to 7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proved to be a reproducible and sensitive technique. Reverse-transcriptase polymerase chain reaction (RT-PCR) has also been advocated, and most recently, the advent of targeted next-generation sequencing (NGS) for ALKand other fusions has become possible. This study compares anaplastic lymphoma kinase (ALK) evaluation with all four techniques in resected NSCLC from the large European Thoracic Oncology Platform Lungscape cohort.
Details
- Language :
- English
- ISSN :
- 15560864 and 15561380
- Volume :
- 13
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of Thoracic Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs44043805
- Full Text :
- https://doi.org/10.1016/j.jtho.2017.11.117