1. Beta-globin gene cluster haplotype distribution in five Brazilian Indian tribes
- Author
-
Bevilaqua, Lia R.M., Mattevi, Vanessa S., Ewald, Gisele M., Salzano, Francisco M., Coimbra, Carlos E.A., Jr., Santos, Ricardo V., and Hutz, Mara H.
- Subjects
Native Americans -- Brazil ,South American native peoples -- Brazil ,Tribes -- Genetic aspects ,Heterozygosis -- Research ,Human population genetics -- Research ,Anthropology/archeology/folklore - Abstract
Haplotypes derived from five polymorphic restriction sites in the beta-globin gene cluster were investigated in 139 individuals from five different Brazilian Indian tribes by the polymerase chain reaction (PCR). Eight haplotypes were identified. Haplotypes 2 (+----) and 6 (-++-+) were the most frequent and were common to all tribes. Their prevalences ranged from 60% to 93% and from 3% to 18%, respectively. Average heterozygosity measured by the Gini-Simpson index is markedly reduced among these Brazilian Indians when compared with Europeans (56%), but much less (8%) in relation to Asiatics, suggesting the absence of an important bottleneck effect in the early colonization of South America. The coefficient of gene differentiation (GST[prime]) was estimated as 0.082 among six Brazilian Indian tribes, but when only three Tupi-Monde-speaking tribes were considered, this estimate was reduced to 0.030. KEY WORDS DNA polymorphism, Genetic diversity, Amerindians, Hemoglobin
- Published
- 1995