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Beta-globin gene cluster haplotype distribution in five Brazilian Indian tribes
- Source :
- American Journal of Physical Anthropology. Dec, 1995, Vol. 98 Issue 4, p395, 7 p.
- Publication Year :
- 1995
-
Abstract
- Haplotypes derived from five polymorphic restriction sites in the beta-globin gene cluster were investigated in 139 individuals from five different Brazilian Indian tribes by the polymerase chain reaction (PCR). Eight haplotypes were identified. Haplotypes 2 (+----) and 6 (-++-+) were the most frequent and were common to all tribes. Their prevalences ranged from 60% to 93% and from 3% to 18%, respectively. Average heterozygosity measured by the Gini-Simpson index is markedly reduced among these Brazilian Indians when compared with Europeans (56%), but much less (8%) in relation to Asiatics, suggesting the absence of an important bottleneck effect in the early colonization of South America. The coefficient of gene differentiation (GST[prime]) was estimated as 0.082 among six Brazilian Indian tribes, but when only three Tupi-Monde-speaking tribes were considered, this estimate was reduced to 0.030. KEY WORDS DNA polymorphism, Genetic diversity, Amerindians, Hemoglobin
Details
- ISSN :
- 00029483
- Volume :
- 98
- Issue :
- 4
- Database :
- Gale General OneFile
- Journal :
- American Journal of Physical Anthropology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.17789443