1. Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE Consortium
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Alexander W. Daudt, Kristina Kjærheim, Paolo Boffetta, Antonio Agudo, Leticia Fernandez, Peter Thomson, Cristina Canova, Alastair Ross, Isabelle Stücker, Diego Serraino, David I. Conway, Marta Vilensky, Rosalina Jorge Koifman, Paul Brennan, Lorenzo Richiardi, Gary J. Macfarlane, Mia Hashibe, Thomas Behrens, Pagona Lagiou, Simone Benhamou, Claire M. Healy, Amy Lee Yuan-Chin, Maria Paula Curado, Victor Wünsch-Filho, Wolfgang Ahrens, Alex D. McMahon, Gwenn Menvielle, Ariana Znaor, Ivana Holcatova, Heribert Ramroth, Jan Hovanec, Danièle Luce, Ana M. B. Menezes, University of Glasgow, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, First Faculty of Medicine Charles University [Prague], University of Athens Medical School [Athens], Universita degli Studi di Padova, University of Turin, Trinity College Dublin, Cancer Registry of Norway, University of Aberdeen, The University of Hong Kong (HKU), L’Hospitalet de Llobregat [Barcelona, Spain], Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), University of Heidelberg, Medical Faculty, Mount Sinai School of Medicine, Department of Psychiatry-Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Bologna, University of Buenos Aires [Argentina], Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Hospital de Clínicas de Porto Alegre (HCPA), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), University of São Paulo (USP), University of Utah School of Medicine [Salt Lake City], National Cancer Institute, NCI: R03CA113157, National Institute of Dental and Craniofacial Research, NIDCR: R03DE016611, European Commission, EC: IC18-CT97-0222, Agence Nationale de la Recherche, ANR, Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP: 01/01768-2, Bundesministerium für Bildung und Forschung, BMBF: 01GB9702/3, Fondation pour la Recherche Médicale, FRM, Fondation ARC pour la Recherche sur le Cancer, ARC, Fondation de France, Ministère des Affaires Sociales et de la Santé, Fifth Framework Programme, FP5: FOR381.88, KFS1069-09-2000, QLK1-CT-2001-00182, Institut National Du Cancer, INCa, Fondo para la Investigación Científica y Tecnológica, FonCyT, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, ANSES, Institut Gustave-Roussy: 88D28, Institut de Veille Sanitaire, InVS, Swiss Cancer Research Foundation: AKT 617, Conway D.I., Hovanec J., Ahrens W., Ross A., Holcatova I., Lagiou P., Serraino D., Canova C., Richiardi L., Healy C., Kjaerheim K., Macfarlane G.J., Thomson P., Agudo A., Znaor A., Brennan P., Luce D., Menvielle G., Stucker I., Benhamou S., Ramroth H., Boffetta P., Vilensky M., Fernandez L., Curado M.P., Menezes A., Daudt A., Koifman R., Wunsch-Filho V., Yuan-Chin A.L., Hashibe M., Behrens T., McMahon A.D., Università degli Studi di Padova = University of Padua (Unipd), Università degli studi di Torino = University of Turin (UNITO), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), University of Bologna/Università di Bologna, Universitad de Buenos Aires = University of Buenos Aires [Argentina], Universidade de São Paulo = University of São Paulo (USP), HAL UR1, Admin, and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)
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Data Analysis ,medicine.medical_specialty ,Epidemiology ,Risk factors in diseases ,Occupational prestige ,[SDV]Life Sciences [q-bio] ,Socioeconomic Factor ,Head cancer ,socioeconomic ,Cancer ,Cancer Epidemiology ,Occupational ,Socioeconomic ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Epidemiology of cancer ,medicine ,Humans ,030212 general & internal medicine ,Socioeconomic status ,Càncer de cap ,Original Research ,business.industry ,Factors de risc en les malalties ,Prestige ,Risk Factor ,Head and neck cancer ,Public Health, Environmental and Occupational Health ,Case-control study ,South America ,medicine.disease ,Neck cancer ,Càncer de coll ,[SDV] Life Sciences [q-bio] ,Europe ,Data Analysi ,Socioeconomic Factors ,cancer: occupational ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Case-Control Studies ,cancer epidemiology ,business ,Case-Control Studie ,Psychosocial ,Demography ,Human - Abstract
BackgroundThe association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures.MethodsPooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige—Treiman’s Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position—International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs.ResultsFor the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94).ConclusionsThese findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work.
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- 2020