1. Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach
- Author
-
Yongning Wu, Qinghua He, Huiru Tang, Pingping Ren, Xiangfeng Kong, Guoyao Wu, Fuhua Hao, Peng Li, François Blachier, Yulong Yin, State Key Lab Magnet Resonance & Atom & Mol Phys, Chinese Academy of Agricultural Sciences (CAAS), Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, Res Ctr Hlth Breeding Livestock & Poultry, Inst Subtrop Agr, Res Ctr Anim & Poultry Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr, Chinese Academy of Sciences [Changchun Branch] (CAS), Natl Inst Nutr & Food Safety, Chinese CDC, Dept Anim Sci, Texas A&M University [College Station], Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, National Basic Research Program of China [2007CB914701, 2009CB118800], National Natural Science Foundation of China [30901040, 30901041, 30928018, 30828025, 30771558, 31001015, 31001016, 31072042], Chinese Academy of Sciences [KZCX2-EW-412, KSCX1-YW-02, KSCX2-YW-N-051, Y022042020], CAS/SAFEA [20100491005-8, KZCX2-YW-T07], Changsha City Key Project [K1003238-61], GongDong and Chinese Academy Science [GZCQC0802FG06, 20098091300043, 20098030802021], and AgroParisTech-Institut National de la Recherche Agronomique (INRA)
- Subjects
Blood Glucose ,Serum ,[SDV.SA]Life Sciences [q-bio]/Agricultural sciences ,Very low-density lipoprotein ,Magnetic Resonance Spectroscopy ,Swine ,Endocrinology, Diabetes and Metabolism ,Metabolite ,Clinical Biochemistry ,Lipoproteins, VLDL ,Biochemistry ,Choline ,SUPPLEMENTATION ,chemistry.chemical_compound ,High-density lipoprotein ,Insulin ,AMINO-ACIDS ,2. Zero hunger ,0303 health sciences ,INSULIN-RESISTANCE ,Nutrition and Dietetics ,PLASMA ,Chemistry ,030302 biochemistry & molecular biology ,ANIMAL-MODELS ,Metabonomics ,Lipogenesis ,Body Composition ,H-1-NMR SPECTROSCOPY ,CHILDHOOD OBESITY ,Lipoproteins, HDL ,medicine.medical_specialty ,Obese pigs ,DIABETIC FATTY RATS ,PHENOTYPES ,Creatine ,Methylamines ,03 medical and health sciences ,Insulin resistance ,Lean pigs ,Lipid oxidation ,Internal medicine ,medicine ,Animals ,Metabolomics ,Obesity ,Molecular Biology ,MULTIVARIATE DATA-ANALYSIS ,030304 developmental biology ,Lipid metabolism ,Glucagon ,Lipid Metabolism ,medicine.disease ,Endocrinology ,Multivariate Analysis - Abstract
Childhood obesity has become a prevalent risk to health of children and teenagers. To develop biomarkers in serum for altered lipid metabolism, genetically obese (Ningxiang strain) and lean (DurocxLandracexLarge Yorkshire strain) growing pigs were used as models to identify potential differences in the serum metabonome between the two strains of pigs after consuming the same diet for 46 days. At the end of the study, pigs were euthanized for analysis of the serum metabonome and determination of body composition. Obese pigs had higher fat mass (42.3 +/- 8.8% vs. 21.9 +/- 4.5%) and lower muscle mass (35.4 +/- 4.5% vs. 58.9 +/- 2.5%) than lean pigs (P
- Published
- 2012
- Full Text
- View/download PDF