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8 results on '"Nathalie Thieriet"'

1. Food-grade TiO 2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

Author

Jean-Nicolas Audinot, Christel Cartier, Eric Gaultier, Fabrice Pierre, Eric Houdeau, Nathalie Naud, Marie Carrière, Matthieu Réfrégiers, Nathalie Thieriet, Sarah Bettini, Laurence Guzylack-Piriou, Dominique Thiaudière, Elisa Boutet-Robinet, Patrick Grysan, J. Dupuy, Solenn Reguer, Jean Pierre Cravedi, Sylviane Taché, Christine Coméra, ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Materials Research and Technology (MRT) Department, Luxembourg Institute of Science and Technology (LIST), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Laboratoire Lésions des Acides Nucléiques (LAN), Service de Chimie Inorganique et Biologique (SCIB - UMR E3), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), ANSES : PNR- EST-2013-024, NanoGut project, INRA, Contaminants & Stress Cellulaire (ToxAlim-COMICS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Endocrinologie & Toxicologie de la Barrière Intestinale (ToxAlim-ENTeRisk), Neuro-Gastroentérologie & Nutrition (ToxAlim-NGN), Prévention et promotion de la cancérogénèse par les aliments (ToxAlim-PPCA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3)

Subjects
0301 basic medicine, medicine.medical_specialty, Colorectal cancer, Crypt, Stimulation, [SDV.CAN]Life Sciences [q-bio]/Cancer, 02 engineering and technology, [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, Biology, medicine.disease_cause, 03 medical and health sciences, Immune system, Internal medicine, medicine, risk factors, Multidisciplinary, technology, industry, and agriculture, Gastroenterology, Dendritic cell, 021001 nanoscience & nanotechnology, medicine.disease, 3. Good health, 030104 developmental biology, Endocrinology, 0210 nano-technology, Carcinogenesis, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Homeostasis, Aberrant crypt foci
Abstract

Food-grade titanium dioxide (TiO2) containing a nanoscale particle fraction (TiO2-NPs) is approved as a white pigment (E171 in Europe) in common foodstuffs, including confectionary. There are growing concerns that daily oral TiO2-NP intake is associated with an increased risk of chronic intestinal inflammation and carcinogenesis. In rats orally exposed for one week to E171 at human relevant levels, titanium was detected in the immune cells of Peyer’s patches (PP) as observed with the TiO2-NP model NM-105. Dendritic cell frequency increased in PP regardless of the TiO2 treatment, while regulatory T cells involved in dampening inflammatory responses decreased with E171 only, an effect still observed after 100 days of treatment. In all TiO2-treated rats, stimulation of immune cells isolated from PP showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased. E171 or NM-105 for one week did not initiate intestinal inflammation, while a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model. These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO2 from dietary sources.

Published
2017
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2. Food-grade TiO

Author

Sarah, Bettini, Elisa, Boutet-Robinet, Christel, Cartier, Christine, Coméra, Eric, Gaultier, Jacques, Dupuy, Nathalie, Naud, Sylviane, Taché, Patrick, Grysan, Solenn, Reguer, Nathalie, Thieriet, Matthieu, Réfrégiers, Dominique, Thiaudière, Jean-Pierre, Cravedi, Marie, Carrière, Jean-Nicolas, Audinot, Fabrice H, Pierre, Laurence, Guzylack-Piriou, and Eric, Houdeau

Subjects
Inflammation, Male, Titanium, Carcinogenesis, Colon, T-Lymphocytes, Administration, Oral, Cell Count, Epithelial Cells, Cell Separation, Dendritic Cells, Permeability, Article, Peyer's Patches, Liver, Food, Immune System, Animals, Cytokines, Homeostasis, Tissue Distribution, Rats, Wistar, Precancerous Conditions, DNA Damage, Subcellular Fractions
Abstract

Food-grade titanium dioxide (TiO2) containing a nanoscale particle fraction (TiO2-NPs) is approved as a white pigment (E171 in Europe) in common foodstuffs, including confectionary. There are growing concerns that daily oral TiO2-NP intake is associated with an increased risk of chronic intestinal inflammation and carcinogenesis. In rats orally exposed for one week to E171 at human relevant levels, titanium was detected in the immune cells of Peyer’s patches (PP) as observed with the TiO2-NP model NM-105. Dendritic cell frequency increased in PP regardless of the TiO2 treatment, while regulatory T cells involved in dampening inflammatory responses decreased with E171 only, an effect still observed after 100 days of treatment. In all TiO2-treated rats, stimulation of immune cells isolated from PP showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased. E171 or NM-105 for one week did not initiate intestinal inflammation, while a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model. These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO2 from dietary sources.

Published
2016

3. Tandem deprotection-coupling of Nα-Alloc-amino acids by use of ternary systems Pd cat./PhSiH3/carboxy-activated amino acid

Author

Paloma Gomez-Martinez, François Guibé, and Nathalie Thieriet

Subjects
inorganic chemicals, chemistry.chemical_classification, Stereochemistry, Organic Chemistry, chemistry.chemical_element, Peptide, Biochemistry, Catalysis, Amino acid, Acylation, chemistry.chemical_compound, chemistry, Phenylsilane, Drug Discovery, Organic chemistry, Triphenylphosphine, Ternary operation, Palladium
Abstract

Nα-allyloxycarbonyl derivatives of amino acids undergo smooth coupling with various carboxy-activated partners when treated with phenylsilane (PhSiH3) in the presence of catalytic amounts of tetrakis-(triphenylphosphine) palladium.

Published
1999
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4. Use of Alloc-amino acids in solid-phase peptide synthesis. Tandem deprotection-coupling reactions using neutral conditions

Author

Ernest Giralt, Fernando Albericio, Jordi Alsina, Nathalie Thieriet, and François Guibé

Subjects
chemistry.chemical_classification, Tandem, Stereochemistry, Organic Chemistry, Side reaction, Biochemistry, Coupling reaction, Scavenger (chemistry), Amino acid, Catalysis, chemistry.chemical_compound, chemistry, Phase (matter), Drug Discovery, Peptide synthesis
Abstract

The use of Alloc group in SPPS for the Nα protection of amino acids is an alternative to the Boc and Fmoc protecting groups. The smooth removal of Alloc group in neutral conditions with catalytic amounts of Pd(PPh3)4 in the presence of PhSiH3 as a scavenger for the allyl system permits orthogonality with the most common protecting groups. Furthermore, a tandem deprotection-coupling reaction allows the suppression of DKP formation in cases where this side reaction is troublesome.

Published
1997
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5. New allyl group acceptors for palladium catalyzed removal of allylic protections and transacylation of allyl carbamates

Author

Nathalie Thieriet, Albert Loffet, Michèle Dessolin, Marie-George Guillerez, and François Guibé

Subjects
N-methyl-N-(trimethylsilyl)trifluoroacetamide, Allylic rearrangement, Trimethylsilyl, Organic Chemistry, chemistry.chemical_element, Biochemistry, Catalysis, chemistry.chemical_compound, Transacylation, chemistry, Drug Discovery, Organic chemistry, Palladium catalyst, Palladium
Abstract

Allyl carboxylates, carbamates and phenoxides may be cleaved or transacylated in the presence of palladium catalyst and either phenyltrihydrosilane or N-methyl-N-(trimethylsilyl)-trifluoroacetamide. These reactions are totally compatible with the presence of Boc and, as far as phenyltrihydrosilane is concerned, Fmoc protections.

Published
1995
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6. ChemInform Abstract: New Allyl Group Acceptors for Palladium-Catalyzed Removal of Allylic Protections and Transacylation of Allyl Carbamates

Author

Marie-George Guillerez, François Guibé, Albert Loffet, Michèle Dessolin, and Nathalie Thieriet

Subjects
Allylic rearrangement, chemistry.chemical_compound, Transacylation, Trimethylsilyl, chemistry, chemistry.chemical_element, General Medicine, Medicinal chemistry, Palladium catalyst, Catalysis, Palladium
Abstract

Allyl carboxylates, carbamates and phenoxides may be cleaved or transacylated in the presence of palladium catalyst and either phenyltrihydrosilane or N-methyl-N-(trimethylsilyl)-trifluoroacetamide. These reactions are totally compatible with the presence of Boc and, as far as phenyltrihydrosilane is concerned, Fmoc protections.

Published
2010
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7. Solid-phase peptide synthesis in the N→C direction

Author

Fernando Albericio, François Guibé, Jordi Alsina, and Nathalie Thieriet

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Fragment (computer graphics), Stereochemistry, Phase (matter), Condensation process, Peptide synthesis, Phosphonium salt, Peptide
Abstract

Although the solid-phase peptide synthesis in the conventional C N direction is widely used and developed, few attempts have been mentioned for peptide assembly in the reverse N C direction [1,2]. The main advantage of this approach consists of the possibility to generate, directly, peptide fragments with modifications at the C-terminus position (amides, esters). C-terminal modified peptides, which are abundant in nature, have potential interest for therapeutical use. Furthermore, they could be readly engaged in a fragment condensation process.

Published
2006
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8. Solid-phase peptide synthesis in the reverse (N → C) direction

Author

Fernando Albericio, Nathalie Thieriet, and François Guibé

Subjects
chemistry.chemical_compound, Residue (chemistry), chemistry, Stereochemistry, Organic Chemistry, Peptide synthesis, HATU, Physical and Theoretical Chemistry, Protecting group, Peptides, Combinatorial chemistry, Racemization, Biochemistry
Abstract

[reaction: see text] A new strategy for SPPS in the reverse direction based on the use of 2-Cl-trityl resin, an allyl ester as the temporary protecting group, and Cu(OBt)(2)/DIPCDI or HATU/DIEA as the coupling method is described. These conditions ensure good yields with minimal racemization of the C-terminal residue.

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