34 results on '"Natalia N. Zharkova"'
Search Results
2. Multi-course PDT of malignant tumors: the influence on primary tumor, metastatic spreading and homeostasis of cancer patients
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E. V. Filonenko, Valery I. Chissov, Raisa I. Yakubovskaya, Victor V. Sokolov, Garry M. Sukhin, E. R. Nemtsova, Belous Ta, and Natalia N. Zharkova
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medicine.medical_specialty ,Pathology ,business.industry ,Photosens ,medicine.medical_treatment ,Rectum ,Cancer ,Photodynamic therapy ,medicine.disease ,Primary tumor ,medicine.anatomical_structure ,Breast cancer ,medicine ,Radiology ,Esophagus ,business ,Cervix - Abstract
The first clinical trials of photodynamic therapy (PDT) of cancer with two photosensitizers, PHOTOHEME and PHOTOSENS, were started in P.A. Hertzen Research Oncological Institute (Moscow, Russia) in 1992 and 1994. Up to now, 208 patients with primary, recurrent and metastatic malignant tumors (469) of skin (34 patients/185 tumors), breast cancer (24/101), head and neck (30/31), trachea and bronchus (31/42), esophagus (35/35), stomach (31/32), rectum (4/4), vagina and uterine cervix (7/8) and bladder (12/31) have been treated by PDT. One-hundred-thirty patients were injected with PHOTOHEME, 64 patients were injected with PHOTOSENS, 14 patients were injected with PHOTOHEME and PHOTOSENS. Totally, 302 courses of treatment were performed: 155 patients had one course and 53 patients were subjected to two to nine PDT sources with intervals from 1 to 18 months. A therapeutic effect of a one-course and multi- course PDT of malignant tumors (respiratory, digestive and urogenital systems) was evaluated clinically, histologically, roentgenologically, sonographically and endoscopically. The biochemical, hematological and immunological investigations were performed for all the patients in dynamics. Results of our study showed that a multi-course PDT method seems to be perspective in treatment of malignant tumors of basic localizations.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1996
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3. Novel effective sensitizers for photodynamic cancer therapy on the base of chlorin p<formula><roman>6</roman></formula> and its derivatives
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Galina I. Fomina, Natalia I. Kazachkina, Ol'ga A. Efremova, Raisa I. Yakubovskaya, Natalia N. Zharkova, Andrei F. Mironov, and Larisa A. Shitova
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chemistry.chemical_classification ,Aqueous solution ,Base (chemistry) ,medicine.medical_treatment ,Cancer therapy ,Photodynamic therapy ,Absorption (skin) ,Photochemistry ,chemistry.chemical_compound ,chemistry ,In vivo ,Chlorin ,polycyclic compounds ,medicine ,Solubility - Abstract
A series of chlorin p6 derivatives modified at the 3- position of the macrocycle were prepared on the base of purpurin 18. The chlorins obtained have intense absorption maxima in the range of 665 - 698 nm and posses good water- solubility. Studying photodynamic activity of these sensitizers in vitro showed that the most effective was 3- devinyl-3-formylchlorin p6. This sensitizer demonstrated also enhanced in vivo affinity to the tumor tissue in comparison to other chlorins, which correlated with the pH values of aqueous solutions of sensitizers studied.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1996
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4. Pharmocokinetical study of Al- and Zn-sulphonated phthalocyanines
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Raisa I. Yakubovskaya, Natalia I. Kazachkina, Eugeny A. Lukyanets, Galina I. Fomina, Victor V. Sokolov, and Natalia N. Zharkova
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Kidney ,medicine.medical_treatment ,Sodium ,Kinetics ,chemistry.chemical_element ,Spleen ,Photodynamic therapy ,Fluorescence ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Biochemistry ,medicine ,Biophysics ,Ammonium ,Sensitization - Abstract
The comparative pharmacokinetical study of Al- and Zn- sulphonated phthalocyanines (AlPcS and ZnPcS, respectively) is the aim of the present work. Mice bearing solid Ehrlich tumor were used in this study. AlPcS (sodium salt) and ZnPcS (ammonium and sodium salts were used as photosensitizers. The photosensitizers were injected i/v in various doses. The exogenous fluorescence of tissues (tumor, liver, spleen, kidneys, muscles, skin) was measured dynamically after sensitization. It was shown that all of the photosensitizers under study had similar distribution pattern in organisms of mice and were selectively accumulated in the Ehrlich tumor tissue. The exogenous fluorescence intensity of tissues and it tumor:normal muscle ratio (Cs) depended on the dosage of the preparation, on the time, which had passed after drug injection, and on the stage of tumor growth. It was also shown that the kinetics of the tissue uptake of the studied sensitizers varied to some extent. Thus, the obtained data may be interesting for deeper understanding of the interaction of the dye with malignant tissues.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1996
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5. Photodynamic therapy of early stage cancer of lung, esophagus, and stomach with two different photosensitizers
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L. V. Telegina, T. A. Belous, Victor V. Sokolov, Natalia N. Zharkova, L. A. Vaschakmadze, V. D. Menenkov, V. K. Gladunov, A. K. Trakhtenberg, Valery I. Chissov, E. I. Aristarkhova, George A. Frank, Mamontov As, and E. V. Filonenko
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medicine.medical_specialty ,Lung ,business.industry ,medicine.medical_treatment ,Photosens ,Stomach ,Cancer ,Photodynamic therapy ,medicine.disease ,Gastroenterology ,Early-stage cancer ,medicine.anatomical_structure ,Internal medicine ,medicine ,Esophagus ,business ,Lung cancer - Abstract
The paper presents the results of photodynamic therapy (PDT) of early-stage cancer of lung (17 patients), esophagus (8 patients) and stomach (10 patients). Fifteen patients had second primary tumors. New drugs photoheme and photosens were used as photosensitizers. Complete remission was obtained in 87%. The patients are followed up without relapses to 2.5 years.
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- 1996
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6. Fluorescence examinations of patients with tumors of diferent localizations in the course of photodynamic therapy with photosensitizer photosens
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Valery I. Chissov, E. I. Aristarkhova, Victor V. Sokolov, V. V. Smirnov, Dmitrij N. Kozlov, and Natalia N. Zharkova
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Pathology ,medicine.medical_specialty ,business.industry ,Photosens ,medicine.medical_treatment ,education ,Cancer ,Photodynamic therapy ,Drug accumulation ,medicine.disease ,Fluorescence ,Medicine ,Photosensitizer ,business ,Normal skin - Abstract
In the course of the clinical trials of Photosens (Al-sulphonated phthalocyanine) as a drug for PDT of cancer fluorescence examinations of 45 patients with injected photosensitizer (0.5 - 2.0 mg/kg b.w.) were performed. The aim of these investigations was to study the drug accumulation in normal, inflammatory tissues and tumors of different localizations. The data concerning kinetics of photosensitizer accumulation and its removal from normal skin and lip mucosa are also presented.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1996
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7. Photodynamic therapy (PDT) of malignant tumors by photosensitzer photosens: results of 45 clinical cases
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E. V. Filonenko, Victor V. Sokolov, Georgy N. Vorozhtsov, Raisa I. Yakubovskaya, Margarita B. Zhitkova, Valery I. Chissov, Belous Ta, Natalia N. Zharkova, E. I. Aristarkhova, and V. V. Smirnov
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Pathology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Stomach ,Photosens ,Melanoma ,Cancer ,Photodynamic therapy ,medicine.disease ,medicine.anatomical_structure ,Breast cancer ,medicine ,Sarcoma ,Esophagus ,business ,Nuclear medicine - Abstract
Photosensitizer Photosens is a mixture of sulphonated Al-phthalocyanines with a different number of substituents per phthalocyanine molecule. In the beginning of 1994, this photosensitizer was approved for clinical trials. Since that time till May 1995, 45 patients with 120 tumors were treated by PDT-Photosens. The main tumor localizations were lung (5/6), head and neck (4/4), esophagus (8/8), stomach (2/2), vulva (2/2), bladder (1/1), breast cancer (3/3), skin (basalioma, melanoma, sarcoma Kaposi, mts breast cancer) (20 patients/94 tumors). The lesions were photoirradiated 48-72 h after intravenous injection of Photosens in doses from 0.5 to 2.0 mg/kg b.w. (1.0 mg/kg b.w., on average). PDT was performed by laser power density from 20 to 1400 mW/sq cm (300 mW/sq.cm, on average), energy density varying from 15 to 200 J/sq cm (100 J/sq.cm, on average). The therapeutical effect of PDT was evaluated histologically, endoscopically, roentgenologically and sonographically 3 - 4 weeks after the treatment. Complete regression of tumors was reached in 56%, significant remission was reached in 34%, and partial remission was observed in 10% of cases. The follow-up of patients with complete tumor regression was to 15 months.
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- 1996
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8. Endoscopic fluorescent diagnostics and PDT of early malignancies of lung and esophagus
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A. K. Trakhtenberg, T. A. Belous, E. I. Aristarkhova, E. V. Filonenko, Dmitrij N. Kozlov, Valery I. Chissov, George A. Frank, Victor V. Sokolov, L. V. Telegina, Mamontov As, V. V. Smirnov, V. K. Gladunov, and Natalia N. Zharkova
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Oncology ,medicine.medical_specialty ,Lung ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Complete remission ,Cancer ,Photodynamic therapy ,medicine.disease ,Endoscopy ,medicine.anatomical_structure ,Internal medicine ,medicine ,Radiology ,Stage (cooking) ,Esophagus ,business ,Lung cancer - Abstract
In this paper the results of fluorescence diagnostics and photodynamic therapy of early stage malignancies of lung (17 patients) and esophagus (8 patients) are presented. 13 patients had multiple primary tumors. As photosensitizers the new drugs Photoheme and Photosense were used. Complete remission was obtained in 92%. The patients are followed up without relapses to 2,5 years.
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- 1996
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9. Real-time fluorescence imaging system for cancer diagnostics
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Victor V. Sokolov, Valery I. Chissov, Natalia N. Zharkova, Valery V Smirnov, and V. I. Fabelinsky
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Fluorescence-lifetime imaging microscopy ,medicine.medical_specialty ,Materials science ,medicine ,Cancer ,Medical physics ,Photosensitizer ,medicine.disease ,Fluorescence ,Computing systems ,Biomedical engineering - Abstract
A dual-channel imaging system for endoscopic observations of photosensitizer's exogeneous fluorescence has been designed, manufactured and clinically tested. The system is computer- controlled and serves for imaging of malignant tumors.
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- 1996
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10. Fluorescence observations of patients in the course of photodynamic therapy of cancer with the photosensitizer PHOTOSENS
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Maria G. Galpern, Dmitrij N. Kozlov, Georgy N. Vorozhtsov, Valery I. Chissov, E. V. Filonenko, Victor V. Sokolov, V. V. Smirnov, Natalia N. Zharkova, and Garry M. Sukhin
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Pathology ,medicine.medical_specialty ,business.industry ,Photosens ,medicine.medical_treatment ,Cancer ,Photodynamic therapy ,medicine.disease ,Clinical method ,Clinical trial ,medicine ,Cancer research ,Photosensitizer ,business - Abstract
In the course of clinical trials of Photosens (Al-sulphonated phthalocyanine) as a new drug for PDT of cancer fluorescence observations of patients with injected photosensitizer are performed. The aim of current investigations is to develop the clinical method of cancer diagnostics with Photosens, to study the pharmaco-kinetics of the drug in the human body and its retention in tumors.
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- 1995
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11. Photodynamic therapy of cancer with the photosensitizer PHOTOGEM
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Dmitrij N. Kozlov, Natalia N. Zharkova, Garry M. Sukhin, E. V. Filonenko, V. V. Smirnov, Belous Ta, Valery I. Chissov, Victor V. Sokolov, and Raisa I. Yakubovskaya
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Larynx ,medicine.medical_specialty ,business.industry ,Melanoma ,medicine.medical_treatment ,Cancer ,Photodynamic therapy ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Breast cancer ,medicine ,Radiology ,Stage (cooking) ,Esophagus ,business ,Cervix - Abstract
The first clinical trials of photodynamic therapy (PDT) in Russia were started in P. A. Hertzen Moscow Research Oncology Institute in October of 1992. Up to now, 61 patients with primary or recurrent malignant tumors of the larynx (3), trachea (1), bronchus (11), nose (1), mouth (3), esophagus (12), vagina and uterine cervix (3), bladder (2), skin (6), and cutaneous and subcutaneous metastases of breast cancer and melanomas (6) have been treated by PDT with the photosensitizer Photogem. At least partial tumor response was observed in all of the cases, but complete remission indicating no evident tumors has been reached in 51% of the cases. Among 29 patients with early and first stage cancer 14 patients had multifocal tumors. Complete remission of tumors in this group reached 86%.© (1995) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1995
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12. Comparative analysis of different phthalocyanine photosensitizers for experimental PDT of cancer
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Garry M. Sukhin, Galina Sokolova, Irina Novozhilova, Natalia N. Zharkova, Dmitrij N. Kozlov, Maria G. Galpern, Victor V. Sokolov, and Georgy N. Vorozhtsov
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Materials science ,medicine.medical_treatment ,Cancer ,Photodynamic therapy ,Laser ,medicine.disease ,Fluorescence ,law.invention ,chemistry.chemical_compound ,chemistry ,Pharmacokinetics ,law ,Phthalocyanine ,medicine ,Photosensitizer ,Irradiation ,Biomedical engineering - Abstract
summary dose) was carried out 24 hours after the intravenous photosensitizer injection. The animals were killed, dissected and only the standard results, namely one necrose centre of theright round shape on the liver surface, were registered. According to the second method durect PDTexperiments on cancer transplanted animals were conducted using the same laser apparatus. Thephthalocyanines were intravenously injected 48 hours before the irradiation. The transplated tumor irradiation doses were 90 J/cm2 , laser spot was 1 cm in diameter. Each medicine was onjected to 6-10animals. The efficiency of anti-tumor PDT has been estimated by sight 2,3 and 15 days after irradiation by comparison of local tissue reaction (formation of escher under the tumor, absence of the tumor growth signs). The selectivity of photosensitizer accumulation in transpiated tumors 48 hours after intravenous injection was determined on the alive animals with the aid of diagnostic device containing special multi-channel optic fiber, helium-neon laser for excitation of phthalocyanine fluorescence (633 nm, 2 mw) andrecording apparatus. The fluorescence registration was conducted in conditions of the contact betweenlight conducting fiber reception end and the tissue. For each animal from 6 to 10 fluorescence spectra onboth tumor tissue and intact muscle as well were registrated.3. RESULTSComparative pharmacokinetic investigation of the accumulation selectivity in tumors of sullonic acids
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- 1995
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13. Laser-excited fluorescence spectrometric system for tissue diagnostics
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V. V. Smirnov, Yu. N. Polivanov, R. L. Pykhov, Dmitrij N. Kozlov, and Natalia N. Zharkova
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Laser tissue interaction ,law ,business.industry ,medicine.medical_treatment ,medicine ,Photodynamic therapy ,Laser ,business ,Fluorescence spectra ,Fluorescence ,Fluorescence spectroscopy ,Biomedical engineering ,law.invention - Abstract
A compact experimental spectrometric system designed for experimental and clinical fluorescence diagnostic observations of tumors is described. Methods of tumor diagnostics using fluorescence spectra of photosensitizers employed for photodynamic therapy has been developed. The system has been tested in P.A. Hertzen Moscow Research Oncology Institute for direct and endoscopic fluorescence diagnostics of tumors in the course of clinical trials of new domestically produced drugs.
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- 1994
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14. Medical applications of MIR-fiber spectroscopic probes
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Vjacheslav G. Artioushenko, Natalia I. Afanasyeva, Alexander A. Lerman, Alexander P. Kryukov, E. F. Kuzin, Natalia N. Zharkova, Victor G. Plotnichenko, George A. Frank, G. I. Didenko, Victor V. Sokolov, and Wolfgang Neuberger
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- 1994
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15. Synthesis of some water soluble diphthalocyanines of rare earth elements as perspective synthetic PDT dyes
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Vitaly M. Podgaetsky, Y. G. Khused, Larisa G. Tomilova, Victor B. Loschenov, and Natalia N. Zharkova
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Water soluble ,Chemistry ,Reagent ,Rare earth ,Dysprosium ,chemistry.chemical_element ,Organic chemistry - Abstract
Suitable methods for synthesis of water soluble diphthalocyanines of rare earth elements have been developed. The synthesis was carried out by direct sulphonation of corresponding unsubstituted analogues. The sulphonation degree depends on the nature of a sulphonated agent, reaction time and molecular ratio of reagents. This allows us to vary the number of sulpho groups from one to the values corresponding to full sulphonation.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1994
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16. Medical applications of MIR-fiber spectroscopic probes
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G. I. Didenko, Wolfgang Neuberger, Victor V. Sokolov, Alexander A. Lerman, V. G. Plotnichenko, Alexander P. Kryukov, E. F. Kuzin, Natalia I. Afanasyeva, Natalia N. Zharkova, George A. Frank, and Vjacheslav G. Artioushenko
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Optical fiber ,Spectrometer ,Absorption spectroscopy ,business.industry ,Chemistry ,Nanotechnology ,law.invention ,law ,Attenuated total reflection ,Optoelectronics ,Fiber ,Fourier transform infrared spectroscopy ,business ,Absorption (electromagnetic radiation) ,Spectroscopy - Abstract
During last years polycrystalline AgBrCI1 fibers (so-called MIR-fibers) were under close investigation with the goal to use them as remote fiberoptic spectroscopic sensors (1 ,2]. These fibers are transparent in 4 - 1 6 pm range, where the most of fundamental vibrations are placed. The synergy of FTIR-spectrometers with flexible remote fiber sensor offers in some cases major advantages over standard spectroscopic technique. Due to the high level of the absorption in the middle infrared region of most organic compounds the use of evanescent field sensor, where the fiber is used as an attenuated total reflection (ATR) sensing element, is more convenient. Easy remote contact with investigated samples is the another reason to use evanescent type of sensor. In this paper such evanescent fiberoptic sensor combined with FTIR spectrometer is used for cancer diagnostics of tissues. It is well-known now that the structure and composition modifications in malignant tissues lead to associated changes in absorption spectra of tissues [3,4]. Tissue spectra measurements in vitro were made in a set of experiments. One of the main advantage of such technique is that it get possibility of in vivo cancer or some other deceases spectroscopic diagnostics, which could enrich non-invasive methods in clinical diagnostics. These experiments were mainly performed to realize in vivo measurements in future. High flexibility and nontoxicity provide possibility to use this fibers for this purpose in standard or specially constructed endoscopes. The main serious handicap to that study is the complexity of real tissue spectra analysis.
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- 1994
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17. Multichannel fiber system for luminescence diagnostics of tumors
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Alexander Startsev, Vjacheslav G. Artioushenko, M. V. Baryshev, Joseph D. Brown, Victor B. Loschenov, Alexander Krjukov, Natalia N. Zharkova, and Kelly B. Moran
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Reproducibility ,Optical fiber ,Materials science ,Scattering ,business.industry ,Optical engineering ,law.invention ,Optics ,law ,Fiber laser ,Reflection (physics) ,Emission spectrum ,Luminescence ,business ,Biomedical engineering - Abstract
Fiber-optic catheters currently in use make it impossible to solve the main problem of spectral fluorescence diagnostics and to provide the high accuracy and reproducibility of in vivo tissue fluorescence investigations. It is well known that fluorescence signal intensity is varied with distance and angle between the biological tissue and the distal tip of the catheter. Signal intensity also depends on the arrangement of light delivery fibers relative to light collecting fibers. Taking these things into account, we developed a design for catheters which allows them to perform the endoscopical diagnostics of tumors with substantial reduction of confusing influences. The new catheters have been tested in preclinical and clinical practice. Their design fits the requirements of certain diagnostic aims, but could also be specified for other applications: measurements of reflection and scattering characteristics of the object, plasma emission spectra (during lithotripsy or angioplasty), etc. There also are wide areas of possible applications for spectra measurements of gaseous, liquid, or solid substances in biology and chemistry.© (1992) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1992
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18. Spectral fluorescence analysis of HpD and photosun-II distribution in mice with spontaneous adenocarcinoma of the breast
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Natalia N. Zharkova
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Pathology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,education ,Photodynamic therapy ,medicine.disease ,Fluorescence ,Molecular biology ,Tumor morphology ,Tissue optics ,Blood concentration ,medicine ,Adenocarcinoma ,Distribution (pharmacology) ,Photosensitizer ,business - Abstract
Using spectral fluorescence analysis the distribution of HpD and Photosun - II has been studied in mice with spontaneous adenocarcinoma of the breast. As a preliminary step the comparative morphological analysis of spontaneous adenocarcinoma has been carried out. It has been shown that photosensitizer distribution nature depends on tumor morphology. The tumor fluorescence contrast has been observed only after HpD administration while Photosun-Il has been found in high blood concentration 24 hours after i. v. administration. 1.© (1990) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1990
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19. Spectral fluorescence analysis and photodynamic activity of some phthalocyanines in experiments in vivo
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Oleg L. Kaliya, E. A. Lukinetc, Victor B. Loschenov, M. V. Baryshev, Natalia N. Zharkova, and V. E. Normansky
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Tissue optics ,Chemistry ,In vivo ,medicine.medical_treatment ,education ,medicine ,Photodynamic therapy ,Combinatorial chemistry ,Fluorescence ,Preclinical imaging ,Biomedical engineering - Abstract
A great variety of new chemical compounds, potential photosensitizers, require testing their photodynamic activity ( PDA ) and tumor localizing capacity. Comparative analysis of phthalocyanines according to qiven criteria seems to be urgent, phthalocyanines being most prospective photosensitizers for photodynamic therapy ( PDT ) of malignant tumors ( 1, 2 ). The absence of scientificly based correlations between the compound chemical structure and its photodynamic activity puts forward the task of initial screening estimation of photosensitizing and tumor localizing properties of chemical compounds.© (1990) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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- 1990
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20. Clinical fluorescence diagnostics in the course of photodynamic therapy of cancer with the photosensitizer PHOTOGEM
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V. V. Smirnov, Natalia N. Zharkova, Valery I. Chissov, Victor V. Sokolov, Dmitrij N. Kozlov, and E. V. Filonenko
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Oncology ,medicine.medical_specialty ,Pathology ,business.industry ,medicine.medical_treatment ,Cancer ,Photodynamic therapy ,medicine.disease ,Fluorescence ,Fluorescence spectra ,Cancer treatment ,Clinical trial ,Internal medicine ,Medicine ,Photosensitizer ,business - Abstract
The results are described of the first clinical fluorescence diagnostic observations of tumors, carried out in P. A. Hertzen Moscow Research Oncology Institute in the course of clinical trials of a new HpD-type photosensitizer Photogem, developed for cancer treatment by photodynamic therapy. The method of tumor diagnostics using fluorescence spectra of photogem has been developed and a designed spectrometric system has been tested.
21. Development of the voiceless sibilant fricative contrast in three-year-olds: an ultrasound and acoustic study.
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Zharkova N
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- Acoustics, Adolescent, Adult, Child, Humans, Language, Speech, Phonetics, Speech Acoustics
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The study analysed spectral and tongue shape dynamics of voiceless alveolar and postalveolar fricatives produced by ten children learning Scottish English. Synchronised ultrasound tongue imaging data and acoustic data were used to characterise children's productions of the phonemic contrast. Six children had consistently accurate productions of both fricative targets, with some cross-consonant phonetic differences in the direction previously demonstrated for older children and adults, as well as some immature acoustic and articulatory dynamic patterns. Instrumental analyses made it possible to describe tongue shape for phonemic errors and phonetically distorted realisations. There was some evidence of articulatory contrast in production preceding contrast in perception. The observed patterns can be explained by the complex articulatory demands on the fricative production, in combination with the developing control of articulators. The paper concludes by discussing the implications of the results for phonological theory and for speech therapy practice.
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- 2021
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22. The Impact of Real-Time Articulatory Information on Phonetic Transcription: Ultrasound-Aided Transcription in Cleft Lip and Palate Speech.
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Cleland J, Lloyd S, Campbell L, Crampin L, Palo JP, Sugden E, Wrench A, and Zharkova N
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- Articulation Disorders diagnostic imaging, Articulation Disorders physiopathology, Child, Child, Preschool, Cleft Lip diagnostic imaging, Cleft Palate diagnostic imaging, Computer Systems, Copying Processes, Female, Humans, Male, Observer Variation, Phonetics, Reproducibility of Results, Software, Speech Production Measurement instrumentation, Speech-Language Pathology instrumentation, Tongue diagnostic imaging, Tongue physiopathology, Ultrasonography instrumentation, Articulation Disorders etiology, Cleft Lip complications, Cleft Palate complications, Documentation methods, Speech Production Measurement methods, Speech-Language Pathology methods, Ultrasonography methods
- Abstract
Objective: This study investigated whether adding an additional modality, namely ultrasound tongue imaging (UTI), to perception-based phonetic transcription impacted on the identification of compensatory articulations and on interrater reliability., Patients and Methods: Thirty-nine English-speaking children aged 3-12 years with cleft lip and palate (CLP) were recorded producing repetitions of /aCa/ for all places of articulation with simultaneous audio recording and probe-stabilized ultrasound (US). Three types of transcriptions were performed: (1) descriptive observations from the live US by the clinician recording the data, (2) US-aided transcription (UA) by two US-trained clinicians, and (3) traditional phonetic transcription by two CLP specialists from audio recording. We compared the number of consonants identified as in error by each transcriber and then classified errors into eight different subcategories., Results: Both UA and traditional transcription yielded similar error detection rates; however, these were significantly higher than the observations recorded live in the clinic. Interrater reliability for the US transcribers was substantial (κ = 0.65) compared to moderate (κ = 0.47) for the traditional transcribers. US transcribers were more likely to identify covert errors such as double articulations and retroflexion than the audio-only transcribers., Conclusion: UTI is a useful complement to traditional phonetic transcription for CLP speech., (© 2019 S. Karger AG, Basel.)
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- 2020
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23. The dynamics of voiceless sibilant fricative production in children between 7 and 13 years old: An ultrasound and acoustic study.
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Zharkova N, Hardcastle WJ, and Gibbon FE
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- Adolescent, Child, Female, Humans, Male, Phonetics, Speech physiology, Speech Acoustics, Speech Production Measurement methods, Tongue physiology, Ultrasonic Waves
- Abstract
This study reports on dynamic tongue shape and spectral characteristics of sibilant fricatives /s/ and /ʃ/ in Scottish English speaking children aged between 7 and 13 years old. The sequences /əCa/ and /əCi/ were produced by 40 children, with ten participants in each age group, and two-year intervals between successive groups. Productions of the same sequences by ten adults were used for comparison with the children's data. Quantitative dynamic analyses were carried out on spectral information and on ultrasound imaging data on tongue shape. All age groups differentiated between the two consonants in the fricative centroid and in tongue shape. Vowel-on-consonant effects showed consonant-specific patterns across age groups without a consistent increase or decrease in the extent of coarticulation with increasing age. The extent of discriminability between the two fricatives increased with age on both acoustic and articulatory measures. Younger speakers were generally more variable than older speakers. Complementary findings from the centroid and tongue shape measures suggest that age-related differences are due to the ongoing maturation of controlling the tongue in coordination with other articulators, particularly the jaw, throughout childhood.
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- 2018
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24. An Ultrasound Study of the Development of Lingual Coarticulation during Childhood.
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Zharkova N
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- Adolescent, Child, Child, Preschool, Female, Humans, Language Development, Linear Models, Male, Speech Acoustics, Speech Production Measurement, Tongue diagnostic imaging, Child Language, Phonetics, Tongue physiology, Ultrasonography
- Abstract
Background/aims: There is growing evidence that coarticulation development is protracted and segment-specific, and yet very little information is available on the changes in the extent of coarticulation across different phonemes throughout childhood. This study describes lingual coarticulatory patterns in 6 age groups of Scottish English-speaking children between 3 and 13 years old., Methods: Vowelon-consonant anticipatory coarticulation was analysed using ultrasound imaging data on tongue shape from 4 consonants that differ in the degree of constraint, i.e., the extent of articulatory demand, on the tongue., Results: Consonant-specific age-related patterns are reported, with consonants that have more demands on the tongue reaching adolescent-like levels of coarticulation in older age groups. Within-speaker variability in tongue shape decreases with increasing age., Conclusion: Reduced coarticulation in the youngest age group may be due to insufficient tongue differentiation. Immature patterns for lingual consonants in 5- to 11-year-olds are explained by the goal of producing the consonant target overriding the goal of coarticulating the consonant with the following vowel., (© 2018 S. Karger AG, Basel.)
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- 2018
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25. Voiceless alveolar stop coarticulation in typically developing 5-year-olds and 13-year-olds.
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Zharkova N
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- Adolescent, Child, Preschool, Female, Humans, Male, Ultrasonography, Child Development, Phonetics, Tongue diagnostic imaging, Tongue physiology
- Abstract
In this study, vowel-on-consonant lingual coarticulation at [t] closure offset was compared in 5-year-old children and 13-year-old adolescents. The study aimed to establish whether, by the end of the closure, children from the younger age group adjust the tongue shape to the following vowels to the same extent as adolescents. Ten 5-year-olds and ten 13-year-olds, all speakers of Scottish Standard English, produced [t]-vowel syllables with the vowels [i] and [a], in a carrier phrase. Measures of tongue shape based on midsagittal ultrasound imaging data were used to compare anticipatory coarticulation and within-speaker variability across groups. Both age groups changed the extent of tongue dorsum bunching in order to coarticulate the consonant with the following vowels. The 5-year-old children, unlike the adolescents, did not consistently modify the bunching location within the tongue curve to accommodate the tongue shape to that of the upcoming vowel. Token-to-token variability was significantly greater in the younger age group. The results suggest that vowel-on-[t] coarticulatory patterns produced by typically developing children are affected by the development of motor control, with articulatory constraints on the tongue limiting the extent of lingual coarticulation in 5-year-old children. The findings on typical coarticulation development are relevant for clinical practice, and they highlight the need for more detailed descriptions of how phonetic characteristics of speech sounds affect coarticulation throughout childhood.
- Published
- 2017
- Full Text
- View/download PDF
26. Using ultrasound tongue imaging to identify covert contrasts in children's speech.
- Author
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Zharkova N, Gibbon FE, and Lee A
- Subjects
- Head Movements physiology, Humans, Speech Acoustics, Speech Production Measurement methods, Speech Disorders, Tongue diagnostic imaging, Ultrasonography methods
- Abstract
Ultrasound tongue imaging has become a promising technique for detecting covert contrasts, due to the developments in data analysis methods that allow for processing information on tongue shape from young children. An important feature concerning analyses of ultrasound data from children who are likely to produce covert contrasts is that the data are likely to be collected without head-to-transducer stabilisation, due to the speakers' age. This article is a review of the existing methods applicable in analysing data from non-stabilised recordings. The article describes some of the challenges of ultrasound data collection from children, and analysing these data, as well as possible ways to address those challenges. Additionally, there are examples from typical and disordered productions featuring covert contrasts, with illustrations of quantifying differences in tongue shape between target speech sounds.
- Published
- 2017
- Full Text
- View/download PDF
27. Ultrasound and acoustic analysis of sibilant fricatives in preadolescents and adults.
- Author
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Zharkova N
- Subjects
- Adolescent, Adult, Age Factors, Child, Female, Humans, Male, Middle Aged, Movement, Signal Processing, Computer-Assisted, Sound Spectrography, Speech Production Measurement, Time Factors, Tongue physiology, Ultrasonography, Young Adult, Acoustics, Phonetics, Speech Acoustics, Tongue diagnostic imaging, Voice Quality
- Abstract
This study describes the production of sibilant fricatives /s/ and /∫/, comparing Scottish English speaking preadolescent children with adults. The materials were the sequences /əCa/ and /əCi/ produced by 15 adults and 15 children aged between 10 and 12 years old. Quantitative analyses were carried out on both spectral information and on ultrasound imaging data on tongue shape, taken from nine successive time points during the fricative. The two groups of speakers were very similar to each other in the articulatory and acoustic characteristics distinguishing the two fricatives. Age-related differences in the fricative centroid measure occurred at consonant-vowel boundaries, with lower values in the preadolescents. Within-speaker variability was mostly similar across age groups, with the exception of the fricative centroid for /∫/, which was significantly more variable in preadolescents than in adults. Throughout the consonant duration, both groups consistently differentiated between the two consonants in both the fricative centroid and in one measure of tongue shape.
- Published
- 2016
- Full Text
- View/download PDF
28. Insights from ultrasound: Enhancing our understanding of clinical phonetics.
- Author
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Cleland J, Scobbie J, and Zharkova N
- Subjects
- Humans, Speech Disorders diagnostic imaging, Phonetics, Speech, Ultrasonography
- Published
- 2016
- Full Text
- View/download PDF
29. Quantifying lingual coarticulation using ultrasound imaging data collected with and without head stabilisation.
- Author
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Zharkova N, Gibbon FE, and Hardcastle WJ
- Subjects
- Adolescent, Data Collection methods, Female, Humans, Male, Reference Values, Tongue physiology, Ultrasonography, Video Recording instrumentation, Head Movements physiology, Phonation physiology, Phonetics, Restraint, Physical instrumentation, Speech physiology, Tongue diagnostic imaging
- Abstract
Previous studies reporting the use of ultrasound tongue imaging with clinical populations have generally provided qualitative information on tongue movement. Meaningful quantitative measures for use in the clinic typically require the speaker's head to be stabilised in relation to a transducer, which may be uncomfortable, and unsuitable for young children. The objective of this study was to explore the applicability of quantitative measurements of stabilisation-free tongue movement data, by comparing ultrasound data collected from 10 adolescents, with and without head stabilisation. Several measures of tongue shape were used to quantify coarticulatory influence from two contrasting vowels on four different consonants. Only one of the measures was completely unaffected by the stabilisation condition for all the consonants. The study also reported cross-consonant differences in vowel-related coarticulatory effects. The implications of the findings for the theory of coarticulation and for potential applications of stabilisation-free tongue curve measurements in clinical studies are discussed.
- Published
- 2015
- Full Text
- View/download PDF
30. Spatial and temporal lingual coarticulation and motor control in preadolescents.
- Author
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Zharkova N, Hewlett N, Hardcastle WJ, and Lickley RJ
- Subjects
- Adolescent, Adolescent Development, Adult, Biomechanical Phenomena physiology, Child, Child Development, Efferent Pathways physiology, Female, Humans, Male, Middle Aged, Speech Acoustics, Tongue diagnostic imaging, Ultrasonography, Young Adult, Movement physiology, Phonetics, Speech physiology, Tongue growth & development, Tongue physiology
- Abstract
PURPOSE In this study, the authors compared coarticulation and lingual kinematics in preadolescents and adults in order to establish whether preadolescents had a greater degree of random variability in tongue posture and whether their patterns of lingual coarticulation differed from those of adults. METHOD High-speed ultrasound tongue contour data synchronized with the acoustic signal were recorded from 15 children (ages 10-12 years) and 15 adults. Tongue shape contours were analyzed at 9 normalized time points during the fricative phase of schwa-fricative-/a/ and schwa-fricative-/i/ sequences with the consonants /s/ and /ʃ/. RESULTS There was no significant age-related difference in random variability. Where a significant vowel effect occurred, the amount of coarticulation was similar in the 2 groups. However, the onset of the coarticulatory effect on preadolescent /ʃ/ was significantly later than on preadolescent /s/, and also later than on adult /s/ and /ʃ/. CONCLUSIONS Preadolescents have adult-like precision of tongue control and adult-like anticipatory lingual coarticulation with respect to spatial characteristics of tongue posture. However, there remains some immaturity in the motor programming of certain complex tongue movements.
- Published
- 2014
- Full Text
- View/download PDF
31. A normative-speaker validation study of two indices developed to quantify tongue dorsum activity from midsagittal tongue shapes.
- Author
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Zharkova N
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Scotland, Speech Acoustics, Speech Production Measurement methods, Speech Production Measurement standards, Ultrasonography, Young Adult, Phonetics, Speech physiology, Speech Articulation Tests methods, Speech Articulation Tests standards, Tongue diagnostic imaging, Tongue physiology
- Abstract
This study reported adult scores on two measures of tongue shape, based on midsagittal tongue shape data from ultrasound imaging. One of the measures quantified the extent of tongue dorsum excursion, and the other measure represented the place of maximal excursion. Data from six adult speakers of Scottish Standard English without speech disorders were analyzed. The stimuli included a range of consonants in consonant-vowel sequences, with the vowels /a/ and /i/. The measures reliably distinguished between articulations with and without tongue dorsum excursion, and produced robust results on lingual coarticulation of the consonants. The reported data can be used as a starting point for collecting more typical data and for analyzing disordered speech. The measurements do not require head-to-transducer stabilization. Possible applications of the measures include studying tongue dorsum overuse in people with cleft palate, and typical and disordered development of coarticulation.
- Published
- 2013
- Full Text
- View/download PDF
32. Using ultrasound to quantify tongue shape and movement characteristics.
- Author
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Zharkova N
- Subjects
- Cleft Palate, Humans, Speech, Speech Production Measurement, Phonetics, Tongue
- Abstract
Objective : Previous experimental studies have demonstrated abnormal lingual articulatory patterns characterizing cleft palate speech. Most articulatory information to date has been collected using electropalatography, which records the location and size of tongue-palate contact but not the tongue shape. The latter type of data can be provided by ultrasound. The present paper aims to describe ultrasound tongue imaging as a potential tool for quantitative analysis of tongue function in speakers with cleft palate. A description of the ultrasound technique as applied to analyzing tongue movements is given, followed by the requirements for quantitative analysis. Several measures are described, and example calculations are provided. Measures : Two measures aim to quantify overuse of tongue dorsum in cleft palate articulations. Crucially for potential clinical applications, these measures do not require head-to-transducer stabilization because both are based on a single tongue curve. The other three measures compare sets of tongue curves, with the aim to quantify the dynamics of tongue displacement, token-to-token variability in tongue position, and the extent of separation between tongue curves for different speech sounds. Conclusions : All measures can be used to compare tongue function in speakers with cleft palate before and after therapy, as well as to assess their performance against that in typical speakers and to help in selecting more effective treatments.
- Published
- 2013
- Full Text
- View/download PDF
33. Coarticulation as an indicator of speech motor control development in children: an ultrasound study.
- Author
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Zharkova N, Hewlett N, and Hardcastle WJ
- Subjects
- Adult, Child, Female, Humans, Male, Transducers, Language Development, Phonation physiology, Phonetics, Sound Spectrography, Speech physiology, Tongue diagnostic imaging, Tongue physiology, Ultrasonography instrumentation
- Abstract
There are still crucial gaps in our knowledge about developmental paths taken by children to adult-like speech motor control. Mature control of articulators during speaking is manifested in the appropriate extent of coarticulation (the articulatory overlap of speech sounds). This study compared lingual coarticulatory properties of child and adult speech, using ultrasound tongue imaging. The participants were speakers of Standard Scottish English, ten adults and ten children aged 6-9 years. Consonant-vowel syllables were presented in a carrier phrase. Distances between tongue curves were used to quantify coarticulation. In both adults and children, vowel pairs /a/-/i/ and /a/-/u/ significantly affected the consonant, and the vowel pair /i/-/u/ did not. Extent of coarticulation was significantly greater in the children than in the adults, providing support for the notion that children's speech production operates with larger units than adults'. More within-speaker variability was found in the children than in the adults.
- Published
- 2011
- Full Text
- View/download PDF
34. Adult speakers' tongue-palate contact patterns for bilabial stops within complex clusters.
- Author
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Zharkova N, Schaeffler S, and Gibbon FE
- Subjects
- Adult, Biomechanical Phenomena, Electrodiagnosis, Female, Humans, Male, Middle Aged, Sound Spectrography, Speech Acoustics, Lip physiology, Palate physiology, Phonetics, Speech physiology, Tongue physiology
- Abstract
Previous studies using Electropalatography (EPG) have shown that individuals with speech disorders sometimes produce articulation errors that affect bilabial targets, but currently there is limited normative data available. In this study, EPG and acoustic data were recorded during complex word final /sps/ clusters spoken by 20 normal adults. A total contact (TC) index measured amount of tongue-palate contact during clusters in words such as 'crisps'. Bilabial closure was inferred from the acoustic signal. The TC profiles indicated that normal adults hold their tongues in a steady /s/-like position throughout the cluster; most speakers (85%, n=17) had no significant difference in TC values during bilabial closure compared to flanking fricatives. The results are interpreted as showing that normal speakers produce double bilabial-alveolar articulations for /p/ in these clusters. Although steady state TC profiles were typical of the group, absolute TC values varied considerably between speakers, with some speakers having up to three times more contact than others. These findings add to the knowledge about normal articulation, and will help to improve diagnosis and treatment of individuals with speech disorders.
- Published
- 2009
- Full Text
- View/download PDF
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