Spectral fluorescence analysis and photodynamic activity of some phthalocyanines in experiments in vivo

A great variety of new chemical compounds, potential photosensitizers, require testing their photodynamic activity ( PDA ) and tumor localizing capacity. Comparative analysis of phthalocyanines according to qiven criteria seems to be urgent, phthalocyanines being most prospective photosensitizers for photodynamic therapy ( PDT ) of malignant tumors ( 1, 2 ). The absence of scientificly based correlations between the compound chemical structure and its photodynamic activity puts forward the task of initial screening estimation of photosensitizing and tumor localizing properties of chemical compounds.© (1990) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.