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181 results on '"Najdenski, H."'

1. Coxiella burnetii in ticks and wild birds

Author

Tokarevich, N.K., Panferova, Yu.A., Freylikhman, O.A., Blinova, O.V., Medvedev, S.G., Mironov, S.V., Grigoryeva, L.A., Tretyakov, K.A., Dimova, T., Zaharieva, M.M., Nikolov, B., Zehtindjiev, P., and Najdenski, H.

Published
2019
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2. Is reliable helicobacter pylori detection in saliva possible?

Author

Dyankov, G., Najdenski, H., Kasovski, V., Zaharieva, M., Kisov, H., Hikova, E., Dimitrova, T., and Malinowski, N.

Subjects
*HELICOBACTER pylori, *SURFACE plasmon resonance, *PYLORUS, *SALIVA, *BLOOD proteins, *GASTRIC mucosa
Abstract

Detection of H. pylori in saliva is difficult because of its lower concentration there than in the stomach and the presence in the oral cavity of uncharacterized bacteria similar to H. pylori. Therefore, a detection method of high specificity and sensitivity is required. In this study we report such a method involving Surface Plasmon Resonance (SPR) that provides direct detection based on the binding of H. pylori to the blood protein Leb. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Contributors

Author

Agrawal, C., primary, Arumugam, M., additional, Bharti, A., additional, Chakdar, H., additional, Chatterjee, A., additional, Contreras-Porcia, L., additional, Fernandes, B., additional, Geada, P., additional, Hongsthong, A., additional, Jantaro, S., additional, Kageyama, H., additional, Kanwal, S., additional, Kroumov, A.D., additional, Kumar, M., additional, Kuzhiumparambil, U., additional, Madamwar, D., additional, Miller, C.D., additional, Modenes, A.N., additional, Najdenski, H., additional, Nakamoto, H., additional, Pabbi, S., additional, Pandey, A., additional, Prasanna, R., additional, Rahman, A., additional, Rai, R., additional, Rai, L.C., additional, Rajesh, K., additional, Ralph, P.J., additional, Rastogi, R.P., additional, Rohit, M.V., additional, Scheufele, F.B., additional, Senachak, J., additional, Singh, S., additional, Sonani, R.R., additional, Takabe, T., additional, Tanaka, Y., additional, Thapa, S., additional, Trigueros, D.E.G., additional, Udayan, A., additional, Vasconcelos, V., additional, Venkata Mohan, S., additional, Vicente, A., additional, Waditee-Sirisattha, R., additional, Yadav, S., additional, and Zaharieva, M., additional

Published
2017
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11. Extraction of bioactive compounds from conifers of the Windsor Great Park and other habitats. Bulgarian Chemical Communications

Author

Najdenski, H., Angelov, G., Kalotova, G., Atanassova, T., Ilieva, Y., Kokanova-Nedialkova, Z., Nedialkov, P., Anderson, J., Adams, R., and Ivanova, D.

Subjects
Antioxidants, Antiproliferative activity, Chamaecyparis Spach., Cupressus L., Juniperus L., Taxus L
Abstract

The present study is aimed at identification of antioxidant and antiproliferative compounds in extracts of conifers originating from the Windsor Great Park (WGP), UK, and other arboretums. Species of the genera Juniperus, Cupressus, Chamaecyparis and Taxus were studied. Rare representatives of J. indica, J. squamata, J. pingii, J. recurva, J. davurica etc., as well as widely distributed species and cultivars were analyzed. Antioxidant activities were evaluated by total polyphenol content (TPC) and half-maximum DPPH-radical scavenging concentrations (DPPH-SC50) of the extracts. Antiproliferative activities were determined by half-maximum growth-inhibitory concentrations (IC50) obtained after MTT-assay of NB4 acute promyelocytic leukemia cells treated with the corresponding extracts. In this group of studied conifers, J. indica leaves extract was determined as the best antioxidant agent with DPPH-SC50 52 g/ml and TPC 320±10 GAE mg/g extract. The best antiproliferative properties were demonstrated by the leaves extracts of J. virginiana cultivars with NB4-IC50 in the range of 0.27-0.31 g/ml. Remarkable cytotoxic activity was found also for J. × pfitzeriana, J. pingii var. wilsonii and T. baccata leaves extracts. Rare species, such as J. indica and J. recurva "Embley Park", also showed high antiproliferative activity. Podophyllotoxin was identified in the best cytotoxic extracts obtained from J. virginiana and J. × pfitzeriana cultivars. Identification of other metabolites in the efficient bioactive extracts is in progress. The present results revealed various conifers as potential sources of cytotoxic and antioxidant lead compounds for prevention of the living organisms from oncogenic, degenerative or other radical-induced diseases.

Published
2020

17. Coxiella burnetiiin ticks and wild birds

Author

Tokarevich, N.K., Panferova, Yu.A., Freylikhman, O.A., Blinova, O.V., Medvedev, S.G., Mironov, S.V., Grigoryeva, L.A., Tretyakov, K.A., Dimova, T., Zaharieva, M.M., Nikolov, B., Zehtindjiev, P., and Najdenski, H.

Abstract

The study objective was to get more information on C. burnetiiprevalence in wild birds and ticks feeding on them, and the potentialities of the pathogen dissemination over Europe by both.

Published
2019
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18. Attenuation and preserved immunogenic potential of Yersinia pseudotuberculosis mutant strains evidenced in oral pig model

Author

Najdenski, H, Golkocheva-Markova, E, Kussovski, V, Vesselinova, A, Garbom, Sara, Wolf-Watz, Hans, Najdenski, H, Golkocheva-Markova, E, Kussovski, V, Vesselinova, A, Garbom, Sara, and Wolf-Watz, Hans

Abstract

Experimental oral infection of pigs with a parental Yersinia pseudotuberculosis strain pIB102, serotype O:3 and two mutant isogenic strains - pIB155,DeltayopK and pIB44,DeltaypkA has been carried out. Clinical findings, microbiological and immunological parameters were examined in dynamics from day 7 to day 60 post-infection (p.i.). All types of infections ran asymptomatically, without hyperthermia, loss of appetite, etc. Experiments on the blood parameters demonstrated a transient leucocytosis with lymphocytosis and monocytosis better expressed after yopK infection. Even though pig is usually known as a reservoir of yersiniae, bacterial colonization was found in mesenterial lymph nodes and tonsils on day 7, respectively 14 p.i. with parental strain, and only in tonsils on day 14 p.i. with both mutant strains. The augmented sensitivity of mutants to the bactericidal effect of leukocytes and blood sera is the characteristic feature of attenuation in their pathogenicity, compared to the parental strain. Comparative in vitro experiments on the immune response and immunostimulating capacity of Y. pseudotuberculosis mutant strains verify their preserved immunogenic potential, predominantly in case of yopK. Hyperplasia and strong activation of the lymph tissue of Peyer's patches, mesenterial lymph nodes, tonsils and spleen of pigs challenged with both mutant strains were proved as immunomorphological rearrangements. The results obtained give the reason to claim that the genetically constructed yopK null mutant strain is significantly attenuated but is still immunogenic and has the potential for a live vaccine carrier strain.

Published
2009
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19. Chemical composition of the brown alga Padina pavonia (L.) Gaill. from the adriatic sea

Author

Kamenarska, Z, Gasic, MJ, Zlatović, Mario, Rašović, Aleksandar, Sladić, Dušan, Kljajic, Z, Stefanov, K, Seizova, K, Najdenski, H, Kujumgiev, A, Tsvetkova, I, Popov, S, Kamenarska, Z, Gasic, MJ, Zlatović, Mario, Rašović, Aleksandar, Sladić, Dušan, Kljajic, Z, Stefanov, K, Seizova, K, Najdenski, H, Kujumgiev, A, Tsvetkova, I, and Popov, S

Abstract

The chemical composition of the brown alga Padina pavonia (L.) Gaill. from the southern Adriatic Sea was investigated. Twelve sterols were identified in the sterol fraction, the main ones being cholesterol and fucosterol. The main fatty acids in the lipids were also identified.The most abundant fatty acid was palmitic acid, followed by oleic and myristic acids.The concentration of polyunsaturated fatty acids was unusually low for a marine alga. By GC/MS analysis of the volatile and polar fractions, 40 compounds were identified. Some of them probably possess defensive functions. In the volatile fraction free fatty acids, aromatic esters, benzyl alcohol and benzaldehyde predominated. Low concentrations of terpenoids, phenols and sulfur containing compounds were also identified.The nbutanol extract contained mainly fatty acids and polyols. Some of the extracts had an antibacterial activity.

Published
2002

46. Modulation of complement activity in Vitro and in Vivo by Yersinia wild and mutant strains.

Author

Yordanov, M., Golkocheva, E., and Najdenski, H.

Abstract

The ability of released proteins (Yops) and surface lipopolysaccharides (LPS) from the wild-type strain Yersinia enterocolitica 8081-L2, serotype O:8 to influence the complement activity was determined. Yops and LPS from wild-type and mutant strains showed different ability to affect the classical pathway (CP) functional complement activity in vitro. The serum CP activity was inhibited during the infection induced with six Y. enterocolitica and three Y. pseudotuberculosis strains in rabbits. The changed complement activity might be of importance for the course of Yersinia infections. [ABSTRACT FROM AUTHOR]

Published
2006
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47. Comparative Study of the Volatile Compounds from Some Black Sea Brown Algae.

Author

Kameranska, Z., Dimitrova-Konaklieva, S., Stefanov, K., Najdenski, H., Tzvetkova, I., and Popov, S.

Subjects
BROWN algae, PLANT classification, ALGAE, VOLATILE organic compounds, BIOLOGICAL evolution, PHYCOLOGY
Abstract

Volatile compounds from seven species of brown algae, widespread in the Black Sea, were obtained by distillation­extraction and investigated by GC/MS. Different groups of compounds were identified: hydrocarbons, alkylated benzenes, alcohols, phenols, aldehydes, ketones, acids, esters, terpenes, sulfur- and chlorine­containing compounds. On the basis of their qualitative and semi-quantitative composition some conclusions about the taxonomy and evolution of the species investigated are proposed. The functions of some of the volatile compounds are discussed. [ABSTRACT FROM AUTHOR]

Published
2002

48. Experimental Mixed Infection of Rabbits with Yersinia enterocolitica andListeria monocytogenes.

Author

NAJDENSKI, H and VESSELINOVA, A

Subjects
*MIXED infections, *LABORATORY rabbits, *YERSINIA enterocolitica infections in animals, *LISTERIA monocytogenes
Abstract

Experimental mixed infection was reproduced in rabbits after per os infection with Yersinia enterocolitica serotype 0:3 cells. Four days later some of animals were re-infected orally with Listeria monocytogenes serotype 4b cells. A third group of healthy rabbits was also infected per os with Listeria monocytogenes . The infectious process was followed dynamically from days 1–28. The experimental animals were examined for clinical, paraclinical and morphological findings. Augmentation of body temperature and alveolar macrophage number, a decreased number of peritoneal macrophages, leucopenia as well as purulent meningoencephalitis, catarrhal pneumonia, lienitis, lymphadenitis and enteritis were detected after experimental mixed infection. Both types of macrophages demonstrated a weak bactericidal activity against Yersinia enterocolitica and a highly expressed killing effect against Listeria monocytogenes . Yersinia and Listeria cells were isolated from the viscera and brain. Both species of bacteria were established intracellularly in the macrophages by electron-microscopic examination. The data received showed that mixed Yersinia enterocolitica 0:3 and Listeria monocytogenes 4b infection of rabbits runs with transitory hyperthermia as a generalized infection and is similar to the Listeria mono-infection. The immunosuppressive effect induced by oral Yersinia enterocolitica infection of rabbits promotes the expression of listerious agents. [ABSTRACT FROM AUTHOR]

Published
2002
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49. Isolation of Pathogenic Yersiniae from Wild Animals in Bulgaria.

Author

Nikolova, S., Tzvetkov, Y., Najdenski, H., and Vesselinova, A.

Subjects
YERSINIA, VETERINARY virology
Abstract

Pathogenic Yersinia strains were isolated between December 1998 and April 1999 from 37 wild animals: rabbit (Lepus europeus), boar (Sus scrofa scrofa), asiatic jackal (Canis aureus), red fox (Vulpes vulpes), mouflon (Ovis musimon), european river otter (Lutra lutra), beech marten (Martes foina), polecat (Mustela putorius) and wild cat (Felis silvestris). It was established that among the wild animals Y. enterocolitica strains of serotype 0:3 predominated, accompanied by Y. pseudotuberculosis strains of serotype 0:3. In one sample from asiatic jackal and one sample from rabbit, Y. enterocolitica serotype 0:8 was isolated. Yersinia enterocolitica and Y. pseudotuberculosis strains were isolated from tonsils and tongues as well as from the viscera – lung, liver, heart, spleen, kidney and lymph nodes, mainly in young animals (1–2 years of age). The results showed that wild animals are a possible natural reservoir for pathogenic Y. enterocolitica and Y. pseudotuberculosis and are included in the epidemiological chain of yersinioses. [ABSTRACT FROM AUTHOR]

Published
2001
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50. Studies of Yersinia enterocolitica 0 : 3 Experimental Infection in Pigs.

Author

Najdenski, H., Nikolova, S., Vesselinova, A., and Neikov, P.

Subjects
*YERSINIA enterocolitica infections, *SWINE diseases
Abstract

Examines the Yersinia enterocolitica infections in pigs. Augmentation of body temperature; Determination of erythrocyte sedimentation rate; Increase in the number of leucocytes, peritoneal and alveolar macrophages.

Published
1998
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