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4 results on '"Naijian Chao"'

1. Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons

Author

Qian Yang, Geng Zhu, Dandan Liu, Jue-Gang Ju, Zhen-Hua Liao, Yi-Xin Xiao, Yue Zhang, Naijian Chao, JieJie Wang, Weidong Li, Jian-Hong Luo, and Sheng-Tian Li

Subjects
Medicine, Science
Abstract

Abstract In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs (ES-NMDARs) dependent LTP haven’t been reported. Here, through the use of a 5-Hz stimulation and MK-801 (an irreversible antagonist of NMDARs) in the CA1 neurons of adult mice hippocampal slices, synaptic NMDARs were selectively inhibited and NMDAR-mediated excitatory postsynaptic currents were not recovered. We found that a robust LTP was induced by 3-train 100-Hz stimulation when the synaptic NMDARs and extrasynaptic NR2B containing NMDARs were blocked, but not in the any of the following conditions: blocking of all NMDARs (synaptic and extrasynaptic), blocking of the synaptic NMDARs, and blocking of the synaptic NMDARs and extrasynaptic NR2A-containing NMDARs. The results indicate that this LTP is ES-NMDARs dependent, and NR2B-containing ES-NMDARs modulates the threshold of LTP induction.

Published
2017
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2. Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons

Author

Jue-Gang Ju, Yue Zhang, Yi-Xin Xiao, Naijian Chao, Zhen-Hua Liao, Jie-jie Wang, Dan-dan Liu, Qian Yang, Geng Zhu, Sheng-Tian Li, Weidong Li, and Jianhong Luo

Subjects
Male, 0301 basic medicine, Postsynaptic Current, Science, Long-Term Potentiation, Stimulation, Hippocampal formation, Receptors, N-Methyl-D-Aspartate, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, mental disorders, LTP induction, Animals, CA1 Region, Hippocampal, Multidisciplinary, Chemistry, Pyramidal Cells, musculoskeletal, neural, and ocular physiology, Excitatory Postsynaptic Potentials, Long-term potentiation, Mice, Inbred C57BL, 030104 developmental biology, nervous system, Anesthesia, Synaptic plasticity, Excitatory postsynaptic potential, Medicine, NMDA receptor, Dizocilpine Maleate, biological phenomena, cell phenomena, and immunity, Excitatory Amino Acid Antagonists, Neuroscience, psychological phenomena and processes, 030217 neurology & neurosurgery
Abstract

In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs (ES-NMDARs) dependent LTP haven’t been reported. Here, through the use of a 5-Hz stimulation and MK-801 (an irreversible antagonist of NMDARs) in the CA1 neurons of adult mice hippocampal slices, synaptic NMDARs were selectively inhibited and NMDAR-mediated excitatory postsynaptic currents were not recovered. We found that a robust LTP was induced by 3-train 100-Hz stimulation when the synaptic NMDARs and extrasynaptic NR2B containing NMDARs were blocked, but not in the any of the following conditions: blocking of all NMDARs (synaptic and extrasynaptic), blocking of the synaptic NMDARs, and blocking of the synaptic NMDARs and extrasynaptic NR2A-containing NMDARs. The results indicate that this LTP is ES-NMDARs dependent, and NR2B-containing ES-NMDARs modulates the threshold of LTP induction.

Published
2017

3. Synaptic and Extrasynaptic Glutamate Signaling in Ischemic Stroke

Author

Naijian Chao and Sheng-Tian Li

Subjects
Central Nervous System, Central nervous system, Glutamic Acid, Neurotransmission, Synaptic Transmission, Biochemistry, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Neurotransmitter, Stroke, Pharmacology, business.industry, Organic Chemistry, Glutamate receptor, medicine.disease, medicine.anatomical_structure, chemistry, Anesthesia, Ischemic stroke, Molecular Medicine, Glutamic acid metabolism, business, Neuroscience
Abstract

Stroke is a leading cause of human mortality and disability where most cases of stroke are ischemic. The central nervous system (CNS) is extremely vulnerable to ischemic stroke particularly due to its unique ability: synaptic transmission. Not only does elaborate synaptic transmission consume extravagant energy that constrains neuronal viability under ischemic conditions, but glutamate, the most predominant neurotransmitter in the CNS, also triggers several catastrophic signaling cascades at both synaptic and extrasynaptic sites when excessively released. These signaling cascades accelerate neuronal death and exacerbate cerebral injuries during ischemic stroke. In this review, we discuss the complete picture of synaptic and extrasynaptic glutamate signaling in ischemic stroke. We hope to provide substantial insights into potential therapies by reviewing recent discoveries that have advanced our understanding of the complex glutamate signaling mechanisms in ischemic stroke.

Published
2014

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