1. Brain Feeding Circuits after Roux-en-Y Gastric Bypass
- Author
-
Mohammed K. Hankir, Michael A. Cowley, Florian Seyfried, and Alexander D. Miras
- Subjects
0301 basic medicine ,positron emission tomography ,Roux-en-Y gastric bypass ,Endocrinology, Diabetes and Metabolism ,NUCLEUS-ACCUMBENS ,Gastric bypass ,Gastric Bypass ,WEIGHT-LOSS ,FOOD REWARD ,feeding behavior ,Neuroimaging ,NEURAL RESPONSIVITY ,Body weight ,Endocrinology & Metabolism ,03 medical and health sciences ,Endocrinology ,Feeding behavior ,Animals ,Humans ,Medicine ,Obesity ,OPIOID RECEPTOR ANTAGONIST ,BARIATRIC SURGERY ,Science & Technology ,GLUCAGON-LIKE PEPTIDE-1 ,business.industry ,Body Weight ,Metabolic surgery ,Brain ,1103 Clinical Sciences ,brain feeding circuits ,VERTICAL SLEEVE GASTRECTOMY ,Surgical procedures ,functional magnetic resonance imaging ,Roux-en-Y anastomosis ,VENTRAL TEGMENTAL AREA ,BODY-WEIGHT ,030104 developmental biology ,1114 Paediatrics and Reproductive Medicine ,Obese subjects ,gastrointestinal tract ,Animal studies ,Nerve Net ,business ,Life Sciences & Biomedicine ,Neuroscience - Abstract
Metabolic surgical procedures, such as Roux-en-Y gastric bypass (RYGB), uniquely reprogram feeding behavior and body weight in obese subjects. Clinical neuroimaging and animal studies are only now beginning to shed light on some of the underlying central mechanisms. We present here the roles of key brain neurotransmitter/neuromodulator systems in food choice, value, and intake at various stages after RYGB. In doing so, we elaborate on how known signals emanating from the reorganized gut, including peptide hormones and microbiota products, impinge on newly mapped homeostatic and hedonic brain feeding circuits. Continued progress in the rapidly evolving field of metabolic surgery will inform the design of more effective weight-loss compounds.
- Published
- 2018