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Brain Feeding Circuits after Roux-en-Y Gastric Bypass
- Source :
- Trends in Endocrinology & Metabolism. 29:218-237
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Metabolic surgical procedures, such as Roux-en-Y gastric bypass (RYGB), uniquely reprogram feeding behavior and body weight in obese subjects. Clinical neuroimaging and animal studies are only now beginning to shed light on some of the underlying central mechanisms. We present here the roles of key brain neurotransmitter/neuromodulator systems in food choice, value, and intake at various stages after RYGB. In doing so, we elaborate on how known signals emanating from the reorganized gut, including peptide hormones and microbiota products, impinge on newly mapped homeostatic and hedonic brain feeding circuits. Continued progress in the rapidly evolving field of metabolic surgery will inform the design of more effective weight-loss compounds.
- Subjects :
- 0301 basic medicine
positron emission tomography
Roux-en-Y gastric bypass
Endocrinology, Diabetes and Metabolism
NUCLEUS-ACCUMBENS
Gastric bypass
Gastric Bypass
WEIGHT-LOSS
FOOD REWARD
feeding behavior
Neuroimaging
NEURAL RESPONSIVITY
Body weight
Endocrinology & Metabolism
03 medical and health sciences
Endocrinology
Feeding behavior
Animals
Humans
Medicine
Obesity
OPIOID RECEPTOR ANTAGONIST
BARIATRIC SURGERY
Science & Technology
GLUCAGON-LIKE PEPTIDE-1
business.industry
Body Weight
Metabolic surgery
Brain
1103 Clinical Sciences
brain feeding circuits
VERTICAL SLEEVE GASTRECTOMY
Surgical procedures
functional magnetic resonance imaging
Roux-en-Y anastomosis
VENTRAL TEGMENTAL AREA
BODY-WEIGHT
030104 developmental biology
1114 Paediatrics and Reproductive Medicine
Obese subjects
gastrointestinal tract
Animal studies
Nerve Net
business
Life Sciences & Biomedicine
Neuroscience
Subjects
Details
- ISSN :
- 10432760
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Trends in Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....16f19eac268cf37123709d59643c71f6