1. Myelination may be impaired in neonates following birth asphyxia
- Author
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Pia Wintermark, Bianca Olivieri, Guillaume Gilbert, Emmanouil Rampakakis, and Aliona Fezoua
- Subjects
Internal capsule ,qMT, quantitative magnetisation transfer ,Hypothermia ,MWF, myelin water fraction ,FOV, field of view ,Myelination ,0302 clinical medicine ,Neonate ,DTI, diffusion-tensor imaging ,Pregnancy ,MRT, magnetisation transfer ratio ,MCR, multicomponent relaxation ,Asphyxia Neonatorum ,medicine.diagnostic_test ,MWI, myelin water imaging ,05 social sciences ,McDESPOT, multi-component driven equilibrium single pulse observation of T1 and T2 ,NBI, no brain injury ,SAR, specific absorption rate ,Brain ,Regular Article ,SNR, signal-to-noise ratio ,DOL, day of life ,TR, repetition time ,3. Good health ,medicine.anatomical_structure ,Neurology ,Anesthesia ,TSE, turbo spin echo ,Hypoxia-Ischemia, Brain ,Gestation ,Female ,NE, neonatal encephalopathy ,medicine.symptom ,Adolescent ,Cognitive Neuroscience ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Neonatal encephalopathy ,050105 experimental psychology ,MR, magnetic resonance ,White matter ,03 medical and health sciences ,Asphyxia ,Magnetic resonance imaging ,BI, brain injury ,medicine ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,RC346-429 ,business.industry ,Infant, Newborn ,Repeated measures design ,ihMT, inhomogenous magnetisation transfer ,medicine.disease ,nervous system ,PLIC, posterior limb of the internal capsule ,TE, time to echo ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,business ,SD, standard deviation ,MRI, magnetic resonance imaging ,030217 neurology & neurosurgery - Abstract
Highlights • Myelination is a developmental process that intensifies after birth during the first years of life. • We used a T2* mapping sequence to assess myelination in healthy and critically ill neonates with neonatal encephalopathy. • Birth asphyxia, in addition to causing the previously well-described direct injury to the brain, may impair myelination., Background Myelination is a developmental process that begins during the end of gestation, intensifies after birth over the first years of life, and continues well into adolescence. Any event leading to brain injury around the time of birth and during the perinatal period, such as birth asphyxia, may impair this critical process. Currently, the impact of such brain injury related to birth asphyxia on the myelination process is unknown. Objective To assess the myelination pattern over the first month of life in neonates with neonatal encephalopathy (NE) developing brain injury, compared to neonates without injury (i.e., healthy neonates and neonates with NE who do not develop brain injury). Methods Brain magnetic resonance imaging (MRI) was performed around day of life 2, 10, and 30 in healthy neonates and near-term/term neonates with NE who were treated with hypothermia. We evaluated myelination in various regions of interest using a T2* mapping sequence. In each region of interest, we compared the T2* values of the neonates with NE with brain injury to the values of the neonates without injury, according to the MRI timing, by using a repeated measures generalized linear mixed model. Results We obtained 74 MRI scans over the first month of life for 6 healthy neonates, 17 neonates with NE who were treated with hypothermia and did not develop brain injury, and 16 neonates with NE who were treated with hypothermia and developed brain injury. The T2* values significantly increased in the neonates with NE who developed injury in the posterior limbs of the internal capsule (day 2: p
- Published
- 2021