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Gastroesophageal reflux disease (GERD) leads to the accumulation of bile-induced reactive oxygen species and oxidative stress in esophageal tissues, causing inflammation and DNA damage. The progression sequence from healthy esophagus to GERD and eventually cancer is associated with a microbiome shift. Lactobacillus species are commensal organisms known for their probiotic and antioxidant characteristics in the healthy esophagus. This prompted us to investigate how Lactobacilli survive in a bile-rich environment during GERD, and to identify their interaction with the bile-injured esophageal cells. To model human reflux conditions, we exposed three Lactobacillus species (L. acidophilus, L. plantarum, and L. fermentum) to bile. All species were tolerant to bile possibly enabling them to colonize the esophageal epithelium under GERD conditions. Next, we assessed the antioxidant potential of Lactobacilli and role in bile injury repair: we measured bile-induced DNA damage using the ROS marker 8-oxo guanine and COMET assay. Lactobacillus addition after bile injury accelerated repair of bile-induced DNA damage through recruitment of pH2AX/RAD51 and reduced NFκB-associated inflammation in esophageal cells. This study demonstrated anti-genotoxic and anti-inflammatory effects of Lactobacilli, making them of significant interest in the prevention of Barrett’s esophagus and esophageal adenocarcinoma in patients with GERD.

Background & Aims: HBV coinfection is common among people living with HIV (PLWH) and is the most important cause of hepatocellular carcinoma (HCC). While risk prediction tools for HCC have been validated in patients with HBV monoinfection, they have not been evaluated in PLWH. Thus, we performed an external validation of PAGE-B in people with HIV/HBV coinfection.Methods: We included data on PLWH from four European cohorts who were positive for HBsAg and did not have HCC before starting tenofovir. We estimated the predictive performance of PAGE-B for HCC occurrence over 15 years in patients receiving tenofovir-containing antiretroviral therapy. Model discrimination was assessed after multiple imputation using Cox regression with the prognostic index as a covariate, and by calculating Harrell's c-index. Calibration was assessed by comparing our cumulative incidence with the PAGE-B derivation study using Kaplan-Meier curves.Results: In total, 2,963 individuals with HIV/HBV coinfection on tenofovir-containing antiretroviral therapy were included. PAGE-B was Conclusions: For individuals with HIV/HBV coinfection, PAGE-B is a valid tool to determine the need for HCC screening. Impact and implications: Chronic HBV infection is the most important cause of hepatocellular carcinoma (HCC) among people living with HIV. Valid risk prediction may enable better targeting of HCC screening efforts to high-risk individuals. We aimed to validate PAGE-B, a risk prediction tool that is based on age, sex, and platelets, in 2,963 individuals with HIV/HBV coinfection who received tenofovir-containing antiretroviral therapy. In the present study, PAGE-B showed good discrimination, adequate calibration, and a cut-off of

Quantum shell effects stabilising fission fragments with various shapes have been invoked as a factor determining the distribution of nucleons between the fragments at scission. Shell effects also induce asymmetric shapes in the nucleus on its way to fission well before the final fragments are (pre)formed. These shell effects are studied in fission of $^{180}$Hg, $^{236}$U and $^{256}$Fm with constrained Hartree-Fock-Bogoliubov calculations using the D1S parametrisation of the Gogny interaction. Strutinsky shell energy correction and single-particle energy level density near the Fermi surface are computed. Several neutron and proton shell effects are identified as drivers towards asymmetric fission. Shell effects are also used to identify the preformation of the fragments in the later stage of fission., 11 pages, 7 figures. References updated

Gastrointestinal worm infections (GWI) constrain pig production and zoonotic pig parasites make pork unsafe for human consumption. This study determined the distributions, determinants and dynamics of GWI and also the effect of the infection on production parameters in pigs reared in Enugu State, Nigeria. The GWI were determined by faecal egg counts following standard procedure. Sixty piggeries and 564 pigs were randomly selected for the study. Questionnaire survey was conducted to obtain data on some production parameters and risk practices aiding GWI in the piggeries. An overall prevalence of 88.3% (53/60) and 68.1% (384/564) at farm and individual pig levels respectively were recorded. High egg counts of single and mixed infections involving Strongyle, Ascaris and Trichuris species were found. The infection predominated in young (74.1%, 240/324) and female (72.3%, 272/376) pigs during the rainy/wet season (74.5%, 204/274). Rearing pigs of different ages together, feeding pigs with untreated abattoir/poultry waste, and unhygienic on-farm feed compounding were the major risk practices underpinning acquisition and spread of GWI. Infected piggeries had less litter weight and reduced mean weight at weaning and maturity. Pre-weaning piglet mortality was 15.5%. The seasonality and preponderance of the infection in young and female pigs are useful epidemiological findings which could be exploited for development of an effective control strategy against the parasitic infections. An overhaul of parasitic disease control measures in piggeries in Enugu State is imperative for greater productivity and profitability in swine production, and to boost availability of safe and wholesome pork for human consumption. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12639-021-01377-y.

A growing literature shows an improvement of chronic hepatitis C virus (HCV)-related depression after successful treatment with direct-acting antivirals. However, depression after HCV cure remains insufficiently documented in people living with HIV (PLWH) and HCV, a population with specific mental health challenges. This study aimed to (i) document the prevalence of moderate-to-severe depression (PHQ-9 score ≥10) across different age classes in HCV-cured PLWH; (ii) identify associated socio-behavioral correlates.Descriptive analyses were performed on data collected during a cross-sectional survey (February 2018 - May 2019) nested in a prospective, multicenter cohort of individuals living with HIV and HCV (ANRS CO13 HEPAVIH). Socio-behavioral correlates of moderate-to-severe depression were identified using logistic regression.Among the 398 HCV-cured individuals in the study sample (median age [IQR]: 56 [53-59] years; 73.1% men), 23.9% presented with moderate-to-severe depression (PHQ-9 score ≥10). Depressive symptom prevalence rates were as follows: anhedonia: 52.3%; feeling 'down' or feelings of hopelessness: 48.3%; sleeping problems: 65.7%; lack of energy: 70.3%; eating disorders: 51.2%; lack of self-esteem: 34.3%; difficulty concentrating: 34.9%; sluggishness (in movement and voice) or restlessness: 24.6%; suicidal ideation: 17.1%. No significant difference was detected across age classes. Female sex, unhealthy alcohol use, sedentary lifestyle, and unhealthy eating behaviors were associated with increased odds of moderate-to-severe depression.Depressive symptoms were common in this sample of HCV-cured PLWH. Unlike findings for the French general population, the prevalence of depression did not decrease with age class. Mental health remains a key issue for HIV-HCV-coinfected individuals, even after HCV cure, especially in women and in individuals with unhealthy behaviors.Despite potential improvements in mental health after successful treatment with direct-acting antivirals, many people living with HIV (PLWH) and hepatitis C virus (HCV) - even in older age classes - still face depressive symptoms after HCV cure. In this population, women and people reporting unhealthy alcohol use, sedentary lifestyle, or unhealthy eating behaviors are more prone to report depressive symptoms after HCV cure. Mental health and lifestyle-related issues should be integrated in a global care model for PLWH living with or having a history of hepatitis C.

The selective targeting of protein-protein interactions remains a significant determinant for the proper modulation and regulation of cell apoptosis. Prototypic galectins such as human galectin-7 (GAL-7) are characterized by their ability to form homodimers that control the molecular fate of a cell by mediating subtle yet critical glycan-dependent interactions between pro- and anti-apoptotic molecular partners. Altering the structural architecture of GAL-7 can therefore result in resistance to apoptosis in various human cancer cells, further illustrating its importance in cell survival. In this study, we used a combination of biophysical and cellular assays to illustrate that binding of a water-soluble meso-tetraarylporphyrin molecule to GAL-7 induces protein oligomerization and modulation of GAL-7-induced apoptosis in human Jurkat T cells. Our results suggest that the integrity of the GAL-7 homodimer architecture is essential for its molecular function, in addition to providing an interesting porphyrin binding modulator for controlling apoptosis in mammalian cells.

E-cigarettes (e-cigs) have drastically increased in popularity during the last decade, especially among teenagers. While recent studies have started to explore the effect of e-cigs in the oral cavity, little is known about their effects on the oral microbiota and how they could affect oral health and potentially lead to disease, including periodontitis and head and neck cancers. To explore the impact of e-cigs on oral bacteria, we selected members of the genus Streptococcus, which are abundant in the oral cavity. We exposed the commensals Streptococcus sanguinis and Streptococcus gordonii and the opportunistic pathogen Streptococcus mutans, best known for causing dental caries, to e-liquids and e-cig aerosols with and without nicotine and with and without menthol flavoring and measured changes in growth patterns and biofilm formation. Our results demonstrate that e-cig aerosols hindered the growth of S. sanguinis and S. gordonii, while they did not affect the growth of S. mutans. We also show that e-cig aerosols significantly increased biofilm formation by S. mutans but did not affect the biofilm formation of the two commensals. We found that S. mutans exhibits higher hydrophobicity and coaggregation abilities along with higher attachment to OKF6 cells than S. sanguinis and S. gordonii. Therefore, our data suggest that e-cig aerosols have the potential to dysregulate oral bacterial homeostasis by suppressing the growth of commensals while enhancing the biofilm formation of the opportunistic pathogen S. mutans. This study highlights the importance of understanding the consequences of e-cig aerosol exposure on selected commensals and pathogenic species. Future studies modeling more complex communities will provide more insight into how e-cig aerosols and vaping affect the oral microbiota.

Background: The generation of potential energy surfaces is a critical step in theoretical models aiming to understand and predict nuclear fission. Discontinuities frequently arise in these surfaces in unconstrained collective coordinates, leading to missing or incorrect results. Purpose: This work aims to produce efficient and physically-motivated computational algorithms to refine potential energy surfaces by removing discontinuities. Method: Procedures based on tree-search algorithms are developed which are capable of smoothing discontinuities in one and two-dimensional potential energy surfaces while minimising their overall energy. Results: Each of the new methods is applied to smooth candidate discontinuities in ${}^{252}\mathrm{Cf}$, ${}^{222}\mathrm{Th}$ and ${}^{218}\mathrm{Ra}$. The effectiveness of each case is analysed both qualitatively and quantitatively. The one-dimensional method is also compared to the adiabatic and linear interpolation approaches which are commonly used to remove discontinuities. Conclusions: The smoothing methods presented in this work are resource-efficient and successful for one- and two-dimensional discontinuities; they will improve the fidelity of potential energy surfaces as well as their subsequent uses in beyond mean-field applications. Complex discontinuities occurring in higher dimensions may require alternative approaches which better utilise prior knowledge of the potential energy surface to narrow their searches., Comment: 17 pages, 18 figures

We present the first-of-its-kind coupling of a continuum full-f gyrokinetic turbulence model with a 6D continuum model for kinetic neutrals, carried out using the Gkeyll code. Our objective is to improve the first-principle understanding of the role of neutrals in plasma fueling, detachment, and their interaction with edge plasma profiles and turbulence statistics. Our model includes only atomic hydrogen and incorporates electron-impact ionization, charge exchange, and wall recycling. These features have been successfully verified with analytical predictions and benchmarked with the DEGAS2 Monte Carlo neutral code. We carry out simulations for a scrape-off layer (SOL) with simplified geometry and National Spherical Torus Experiment parameters. We compare these results to a baseline simulation without neutrals and find that neutral interactions reduce the normalized density fluctuation levels and associated skewness and kurtosis, while increasing auto-correlation times. A flatter density profile is also observed, similar to the SOL density shoulder formation in experimental scenarios with high fueling.

Although drift-ordered fluid models are widely applied in tokamak edge turbulence simulations, the models used are acknowledged not to conserve energy or even electrical charge. The present paper aims to remove many of the existing pitfalls in drift-fluid models, however, with the objective of finding a solution simple enough to be implemented in numerical applications. Our main result is an improved version of the drift-Braginskii equations involving a generalized vorticity function. In the new drift-Braginskii system, the quasi-neutrality condition translates into a transport equation for a generalized vorticity, expressed in conservation form, and related to the total mass-weighted circulation. It is found that kinetic energy conservation can be achieved if the polarization flow is defined recursively. The resulting model conserves the kinetic energy associated with [Formula: see text] and diamagnetic flows and retains the associated perpendicular kinetic energy flux.

E-cigarette (e-cig) vapor has been shown to play a pathological role in oral health and alter the oral microbiota, providing growth advantages for opportunistic pathogens. Enrichment of

Background The indiscriminate slaughter of pregnant goats (SPGs) undermines meat production and food security especially in developing countries. It also connotes animal cruelty, depletion of goat population and may enhance the spread of zoonotic pathogens inhabiting the female reproductive tract during carcass processing. Consequently, this study determined the causes and prevalence of slaughtering pregnant goats for meat in Enugu, Nigeria. The study also estimated the economic losses associated with SPGs, discussed the negative public health consequences and suggested the ways-out. Methods Structured, validated and pilot-tested questionnaire was used to ascertain the reasons for SPGs for meat among 78 willing and randomly selected respondents. The questionnaire survey was conducted in the form of interview. Pregnancy statuses of the goats slaughtered were ascertained by visual inspection and palpation of the eviscerated and longitudinally incised uteri and the horns for macroscopic evidence of pregnancy. Ages of the dams were estimated by dentition method. Estimation of the gestational age was performed by crown-rump length method. The study lasted for six months, comprised of three months (December to March) during the dry/hot season and another three months (May to August) during the wet/rainy season. Economic loss estimation was based on the current monetary values of a matured (30 kilogram) goat and one kilogram of chevon in Enugu, Nigeria; which was determined through market survey. Pearson’s Chi-square test was used to determine whether there were significant (P Results Major reasons adduced for SPGs were: economic hardship (41%), ignorance of the goat’s pregnancy status (21%), increased demand for chevon (13%) and feed scarcity during drought (11%). Of the 1,658 does examined during the six months study, 589 (35.5%) were pregnant. The majority (876/1658, 52.8%) of the female goats slaughtered were in their active reproductive age of ≤ 4 years, while 782 (47.2%) were aged > 4 years. Similarly, majority (1007/1658, 60.7%) of the does/nannies were slaughtered during the dry/hot season. A total of 907 foetuses at first (n = 332, 36.6%), second (n = 486, 53.6%) and third (n = 89, 9.8%) trimesters of gestation were recovered from the 589 PGs. Singleton, twin and triplet pregnancies were observed in 312 (53%), 236 (40%) and 41 (7%) PGs, respectively. About ₦34.44 million ($83,390) would have been earned if the foetuses were born alive and raised to maturity. Additionally, 19,136 kg of chevon, valued at ₦47,841, 000 ($115,838), which would have accrued from the wasted foetuses was also lost. Conclusion Considering the economic, zoonotic and livestock production implications of this work, frantic efforts to reduce SPGs in Enugu, Nigeria is imperative. This could be achieved through advocacy, goat farmers’ enlightenment, ante-mortem pregnancy diagnosis, provision of subsidized feed materials during the dry season and strict enforcement of the Nigerian Meat Edict law, which proscribes unapproved slaughter of gravid animals. These measures may improve food safety and security, improve goat reproduction and production, reduce protein malnutrition, limit dissemination of zoonotic pathogens during carcass processing and hence protect public health in Nigeria.

International audience; No abstract available

Ribonuclease 6 (RNase 6) is one of eight catalytically active human pancreatic-type RNases that belong to a superfamily of rapidly evolving enzymes. Like some of its human homologs, RNase 6 exhibits host defense properties such as antiviral and antibacterial activities. Recently solved crystal structures of this enzyme in its nucleotide-free form show conservation of the prototypical kidney-shaped fold preserved among vertebrate RNases, in addition to revealing the presence of a unique secondary active site. In this study, we determine the structural and conformational properties experienced by RNase 6 upon binding to substrate and product analogs. We present the first crystal structures of RNase 6 bound to a nucleotide ligand (adenosine 5’-monophosphate), in addition to RNase 6 bound to phosphate ions. While the enzyme preserves B(2) subsite ligand preferences, our results show lack of typical B(2) subsite interactions normally observed in homologous ligand-bound RNases. Comparison of the dynamical properties of RNase 6 in its apo, substrate-, and product-bound states highlight unique dynamical properties experienced on time scales ranging from nano- to milliseconds. Overall, our results confirm the specific evolutionary adaptation of RNase 6 relative to its unique catalytic and biological activities.

Obesity is a known risk factor for the development of gastroesophageal reflux disease (GERD), Barrett’s Esophagus (BE) and the progression to esophageal adenocarcinoma. The mechanisms by which obesity contributes to GERD, BE and its progression are currently not well understood. Recently, changes in lipid metabolism especially in the context of a high fat diet have been linked to GERD and BE leading us to explore whether fatty acid oxidation plays a role in the disease progression from GERD to esophageal adenocarcinoma. To that end, we analyzed the expression of the rate-limiting enzyme, carnitine palmytoyltransferase 1A (CPT1A), in human tissues and cell lines representing different stages in the sequence from normal squamous esophagus to cancer. We determined uptake of palmitic acid, the most abundant fatty acid in human serum, with fluorescent dye-labeled lipids as well as functional consequences of stimulation with palmitic acid relevant to Barrett’s tumorigenesis, e.g., proliferation, characteristics of stemness and IL8 mediated inflammatory signaling. We further employed different mouse models including a genetic model of Barrett’s esophagus based on IL1β overexpression in the presence and absence of a high fat diet and deoxycholic acid to physiologically mimic gastrointestinal reflux in the mice. Together, our data demonstrate that CPT1A is upregulated in Barrett’s tumorigenesis and that experimental palmitic acid is delivered to mitochondria and associated with increased cell proliferation and stem cell marker expression.

Gastrointestinal worm infections (GWI) constrain pig production and zoonotic pig parasites make pork unsafe for human consumption. This study determined the distributions, determinants and dynamics of GWI and also the effect of the infection on production parameters in pigs reared in Enugu State, Nigeria. The GWI were determined by faecal egg counts following standard procedure. Sixty piggeries and 564 pigs were randomly selected for the study. Questionnaire survey was conducted to obtain data on some production parameters and risk practices aiding GWI in the piggeries. An overall prevalence of 88.3% (53/60) and 68.1% (384/564) at farm and individual pig levels respectively were recorded. High egg counts of single and mixed infections involving Strongyle, Ascaris and Trichuris species were found. The infection predominated in young (74.1%, 240/324) and female (72.3%, 272/376) pigs during the rainy/wet season (74.5%, 204/274). Rearing pigs of different ages together, feeding pigs with untreated abattoir/poultry waste, and unhygienic on-farm feed compounding were the major risk practices underpinning acquisition and spread of GWI. Infected piggeries had less litter weight and reduced mean weight at weaning and maturity. Pre-weaning piglet mortality was 15.5%. The seasonality and preponderance of the infection in young and female pigs are useful epidemiological findings which could be exploited for development of an effective control strategy against the parasitic infections. An overhaul of parasitic disease control measures in piggeries in Enugu State is imperative for greater productivity and profitability in swine production, and to boost availability of safe and wholesome pork for human consumption.

Summary Production Allocation by geochemical fingerprinting is widely used to quantify relative proportions of liquid hydrocarbons produced from distinct reservoir layers, wells or fields. In some Middle East gas/condensate fields liquid phases are often characterised by only limited compositional differences, and hence, endmember identification can be challenging. This study proposes the use of Multivariate Curve Resolution Alternating Least Square (MCR-ALS) to identify unknown endmembers and to allocate the relative endmembers proportions in commingled fluids. A benchmarking of five distinct analytical techniques (NIR, SimDist, GC2D-MS, GC-FID, LC-UV) interpreted by MCR was performed to assess the MCR accuracy on condensate mixtures artificially prepared. The results show that GC2D-MS and GC-FID coupled with MCR were able to correctly identify unknown endmembers within the tested condensate samples. The quantification of the endmember proportions in artificial mixtures (commingled liquid phase) by MCR without prior endmember selection showed an accuracy of ±3%.

International audience; The study of nucleon-nucleus elastic scattering for spherical targets amounts to solving Schrödinger equation with a given optical potential. This potential can be obtained microscopically by taking as a starting point the interaction between two nucleons. It can also be obtained in a phenomenological way by postulating the geometry of potential and fitting parameters to reproduce experimental data. Microscopic approaches show in general terms that optical potentials are nonlocal, energy-dependent, complex and dispersive. The nonlocality of the potential leads to an integro-differential equation for the wavefunction. We present here a new version of SIDES (Schrödinger Integro-Differential Equation Solver), a code developed with the participation of Jacques Raynal, extended for nonlocal potentials with first-derivative terms.

Ce travail s'inscrit dans le cadre du projet national « Re-Use » visant à étudier la possibilité d'une réutilisation des masques à usage médical après lavage et stérilisation. Les résultats présentés ici concernent l'étude menée entre le CHU de Nancy et le LRGP sur l'influence du lavage et du nombre de lavages sur les performances de onze références différentes de masque. Il ressort de cette étude que le protocole de lavage du CHU de Nancy ne semble pas altérer de façon notable les performances de filtration des différents masques chirurgicaux testés pour lesquels l'efficacité demeure vis à vis des gouttelettes de 3 µm., This study is part of the national "Re-Use" project aimed at studying the possibility of reusing surgical masks after washing and sterilization. The results presented here concern the study carried out between the Nancy University Hospital and the LRGP on the influence of washing and the number of washes on the performances of eleven different mask references. It emerges from this study that the washing protocol of the Nancy University Hospital does not seem to significantly alter the filtration performance of the various surgical masks tested for which the efficiency remains with respect to 3 µm droplets.

The selective targeting of protein-protein interactions remains a significant determinant for the proper modulation and regulation of cell apoptosis. Prototypic galectins such as human galectin-7 (GAL-7) are characterized by their ability to form homodimers that control the molecular fate of a cell by mediating subtle yet critical glycan-dependent interactions between pro- and anti-apoptotic molecular partners. Altering the structural architecture of GAL-7 can therefore result in resistance to apoptosis in various human cancer cells, further illustrating its importance in cell survival. In this study, we used a combination of biophysical and cellular assays to illustrate that binding of a water soluble meso-tetraarylporphyrin molecule to GAL-7 induces protein oligomerization and modulation of GAL-7-induced apoptosis in human Jurkat T cells. Our results suggest that the integrity of the GAL-7 homodimer architecture is essential for its molecular function, in addition to providing an interesting porphyrin binding modulator to control apoptosis in mammalian cells.

This chapter considers how localisation policies may have an effect on the process of technology transfer. It presents a concise resume of technology transfer as a context against which the specific research topic may be set. Companies with weak internal technological capabilities are only likely to be able to localise Research and Development (R&D) services on a collaborative basis with external partners, but at the risk of perpetuating foreign domination of the industry. Systematic implementation of R&D projects of these types may help developing countries to stimulate multinational corporations to develop specific technological options appropriate to developing countries’ conditions and endowments. The development of long-term investment, of effective alliances and of efficient transfer mechanisms depends in essence upon the recognition that all parties concerned need to be able to perceive the possibility of beneficial outcomes. The oil industry represents no more than a particular case of technology management and development.

International audience; No abstract available

Resume La geriatrie est particulierement concernee par la prescription des beta-bloquants et exposee a leurs effets indesirables. Nous rapportons un cas clinique de surdosage en bisoprolol chez une personne âgee, lie a un blocage des voies d’elimination de la substance : insuffisance renale et inhibition des cytochromes impliques. Une revue de la litterature a ete effectuee sur l’ensemble des beta-bloquants a usage systemique afin d’apprehender les facteurs de risque de surdosage en geriatrie. Certains patients, en particuliers les patients âges, peuvent cumuler plusieurs facteurs de risque pharmacocinetique d’accumulation des beta-bloquants. Ceci peut conduire a des surdosages inattendus. La prevention des surdosages accidentels et des effets indesirables des beta-bloquants doit tenir compte des connaissances sur les interactions medicamenteuses et l’elimination des beta-bloquants.

The objectives of this study were to evaluate the potential of an orange Malawian local maize variety MW5021 by comparing with a hybrid variety DKC-9089 for nutritional quality and processing properties such as proximate and mineral composition as well as pasting and thermal properties of the flour, and resistance against Prostephanus truncatus infestation during storage of the grain. Maize plants sampled for the experiments were cultivated under three different fertilizer applications, namely 0, 92 and 184 kg-N/ha, considering the chemical fertilizer input among Malawian smallholder farmers. Even without fertilizer input, significantly higher contents of crude protein, Mg, P, Ca, Fe and Zn were observed in MW5021, as compared with DKC-9089. Among pasting properties, setback of the flour slurry from MW5021 was significantly lower than DKC-9089 for all fertilizer treatments. Two-way ANOVA indicated that MW5021 had significantly lower number of grains damaged by P. truncatus than DKC-9089, throughout 12 weeks of storage experiment at 28±2°C. Thus, this study revealed that the Malawian orange local variety MW5021 retained by the smallholder farmers has considerably higher nutritional quality and P. truncatus resistance as well as lower retrogradation hardening after cooking the flour, than the hybrid maize DKC-9089. Key words: Maize, Mineral composition, pasting properties, postharvest losses, Prostephanus truncatus, Malawi.

In the present study, we have investigated the impact of the tensor force on fission paths, in particular the symmetric and asymmetric barriers in 230 Th, 226 Th, 222 Th and 216 Th isotopes which display an asymmetric to symmetric fission transition. This analysis has been performed within the HFB approach with (Q 20 ,Q 30 ,Q 40 ) as collective variable constraints, using the D1ST2a Gogny+tensor term interaction and comparing to the standard D1S Gogny interaction results. The effects from the tensor term on the potential energy surface landscape, and especially on barrier heights and its topology by opening a new valley in agreement with experimental data, are found to be crucial in the description of exotic actinide fission. We conclude that a tensor term should be integrated to the long range part of the effective interaction for a better description of the fission., Comment: 24 pages, accepted in Phys. Rev. C

We introduce the package SIDES (Schrodinger Integro-Differential Equation Solver) that solves the integro-differential Schrodinger equation for elastic scattering of a nonlocal optical potential in coordinate space. The code is capable of treating the Coulomb interaction without restrictions. The method is based on previous developments by Jacques Raynal in the DWBA07 code. Elastic scattering observables such as differential and integral cross sections, as well as analyzing power and spin rotation functions for both neutron and proton projectiles are evaluated, with no restriction on the type of nonlocality of the potential nor on the beam energy. The corresponding distorted wavefunctions are calculated as well. The SIDES package includes a Perey–Buck potential generator with two parametrizations. It includes as well local potential parametrizations and allows for mixing local and nonlocal contributions. Benchmarks are performed and discussed. Program summary Program Title: SIDES Program Files doi: http://dx.doi.org/10.17632/cmpjgyrngr.1 Licensing provisions: GNU General Public License, Version 2 Programming language: FORTRAN-90 Nature of problem: The description of nucleon elastic scattering off a target nucleus involves solving the Schrodinger’s wave equation for positive incident energy. The determination of scattering observables calls for accurate treatments of the continuum. The effective coupling between the projectile and the target is accounted for by an optical potential, an operator which is by nature complex, energy-dependent and nonlocal. The coupling becomes long-range in the case of charged projectiles. In a general scenario under nonlocal potentials, Schrodinger’s equation becomes an integro-differential equation. Solution method: SIDES solves the Schrodinger integro-differential equation numerically by matrix inversion using Gibbs, Numerov or a modified Numerov method with a uniform radial mesh in a box. The solution is refined by an iterative procedure until a specified precision is achieved. To obtain elastic scattering observables, the associated phase-shifts are calculated via matching of the numerical solution with its analytic asymptotic behavior.

In this work we study the effect of the nuclear tensor force on properties related with deformation. We focus on isotopes in the Mg, Si, S, Ar, Sr and Zr chains within the Hartree–Fock–Bogoliubov theory using the D1ST2a Gogny interaction. Contributions to the tensor energy in terms of saturated and unsaturated subshells are analyzed. Like–particle and proton–neutron parts of the tensor term are independently examinated. We found that the tensor term may considerably modify the potential energy landscapes and change the ground state shape. We analyze too how the pairing characteristics of the ground state change when the tensor force is included.

Early tsunami warning critically hinges on rapid determination of the tsunami hazard potential in real-time, before waves inundate critical coastlines. Tsunami energy can quickly characterize the destructive potential of generated waves. Traditional seismic analysis is inadequate to accurately predict a tsunami’s energy. Recently, two independent approaches have been proposed to determine tsunami source energy: one inverted from the Deep-ocean Assessment and Reporting of Tsunamis (DART) data during the tsunami propagation, and the other derived from the land-based coastal global positioning system (GPS) during tsunami generation. Here, we focus on assessing these two approaches with data from the March 11, 2011 Japanese tsunami. While the GPS approach takes into consideration the dynamic earthquake process, the DART inversion approach provides the actual tsunami energy estimation of the propagating tsunami waves; both approaches lead to consistent energy scales for previously studied tsunamis. Encouraged by these promising results, we examined a real-time approach to determine tsunami source energy by combining these two methods: first, determine the tsunami source from the globally expanding GPS network immediately after an earthquake for near-field early warnings; and then to refine the tsunami energy estimate from nearby DART measurements for improving forecast accuracy and early cancelations. The combination of these two real-time networks may offer an appealing opportunity for: early determination of the tsunami threat for the purpose of saving more lives, and early cancelation of tsunami warnings to avoid unnecessary false alarms.

We study the emergence of neutron gas effects in the description of nuclei with large neutron excess within the Bardeen-Cooper-Schrieffer approach. We consider Ni and Sn isotopes where, in the literature, these effects have been found. We investigate the role of the single particle states with positive energy generating the neutron gas, and we find that the contribution of these states is numerically irrelevant for the various observables that we evaluate., Comment: 12 pages, 7 figures, 3 tables

E-cigarette (e-cig) use is rising, but much is unknown about the effects of its vapor. This vapor contains chemicals such as propylene glycol, a known antimicrobial, and nicotine, whose derivatives are carcinogenic. Here, we study the effects of vaping on resident bacteria of the oral cavity and on oral cell inflammation, which is linked to tumorigenesis. Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii species are significant residents in the oral cavity, with S. mutans the primary cause of dental caries. Growth and biofilm formation is enhanced upon exposure to traditional cigarette smoke in vitro. We aim to analyze the interplay between e-cigarette vapor and oral streptococci colonizing of the oral epithelium. S. mutans, S. sanguinis, and S. gordonii were treated using nicotine-free and 3mg nicotine vapor, as well as double-shot menthol freeze flavored 3mg nicotine vapor in a vape chamber designed to phenocopy physiologically relevant exposure. Next, we analyzed the effects on growth and biofilm formation. Nicotine-independent inhibition of growth occurred upon exposure in all three species. Interestingly, biofilm formation was enhanced in S. mutans while decreased in S. sanguinis and S. gordonii. Upon exposure to the same conditions in the vape chamber, oral epithelial cells showed activation of survival pathways, such as ERK 1/2, by Western blot. Upon coculturing of bacterial and oral epithelial cells at a multiplicity of infection of one for five hours exposed to the same conditions, we observed activation of survival and inflammatory pathways, by Western blot. The pioneer colonizers S. gordonii and S. sanguinis generally antagonize caries-causing S. mutans, which can become a predominant member of the community under appropriate conditions, leading to dental caries formation. The observed decrease in the biofilm formation of the commensals S. sanguinis and S. gordonii upon e-cig vapor exposure indicates the opportunistic colonization of S. mutans, whose biofilm-forming abilities increased. Following e-cig usage, dental caries, periodontitis, and eventually cancer in the oral epithelium may result from this dysbiosis of the microbiome in the oral cavity. Citation Format: Matthew Caldwell, Alma Catala Valentin, Joshua Bernard, Sean Moore, Claudia D. Andl. E-cigarette vapor exposure skews competition between colonizing oral Streptococci to allow biofilm formation of S. mutans and activation of stress and survival pathways in the oral cavity [abstract]. In: Proceedings of the AACR Special Conference on the Microbiome, Viruses, and Cancer; 2020 Feb 21-24; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2020;80(8 Suppl):Abstract nr B03.