135 results on '"N. Amar"'
Search Results
2. The influence of radiation on MHD boundary layer flow past a nano fluid wedge embedded in porous media
- Author
-
N. Amar and N. Kishan
- Subjects
Radiation ,Nanofluid ,Wedge ,bvp4c ,Viscous dissipation ,MHD ,Applied mathematics. Quantitative methods ,T57-57.97 - Abstract
This study takes into account the viscous dissipation of the laminar viscosity and radiation influence of the MHD heat and mass transfer nanofluid flow across two dimensional boundary layers in the porous medium in the existence of heat, thermophoresis and Brownian motion influence. The governing equations are transformed into nonlinear ordinary differential equations by the aid of the similarity transformation. The solution is numerically solved with the MATLAB in the built-in bvp4c solver. The influences of the appropriate flow parameters are analysed in graphs and in tabular form.
- Published
- 2021
- Full Text
- View/download PDF
3. Modeling a Planar Coupled Microstrip Lines using various Wavelets and Method of Moments
- Author
-
M. Bayjja, M. Moubadir, G. Alsharahi, M. Aghoutane, and N. Amar Touhami
- Subjects
Coupled Microstrip Lines, Methods of moments, Wavelets, Sparse matrix, and CPU Time. ,Physics ,QC1-999 ,Electricity and magnetism ,QC501-766 - Abstract
In this paper, we apply a several wavelets basis functions to the method of moments to modeling the parallel-coupled microstrip lines. The first set of equations is for the shielded microstrip line solved with moment’s method and wavelets. The Green’s function is obtained from the theory of images. The second set are for the parallel-coupled microstrip lines operating in the TEM mode or when the analysis can be based on quasi-static approximation, the properties of coupled lines can be determined from the self- and mutual inductances and capacitances for the lines. To demonstrate the effectiveness and accuracy of the proposed technique, numerical results of even- and odd-mode characteristic impedances, coupling coefficient, percentage sparsity achieved in the impedance matrix, the CPU Time to reverse impedance matrix, and error relative for Daubechies, Coiflets, Biorthogonal and Symlets wavelets are presented. Numerical results are in good agreement with those in previous publications.
- Published
- 2019
- Full Text
- View/download PDF
4. Isolation Enhancement Using a Hybrid Technique in an Eight-Element UWB MIMO Antenna Design
- Author
-
A. Mchbal, N. Amar Touhami, H. Elftouh, and A. Dkiouak
- Subjects
Diversity techniques ,MIMO ,mutual coupling ,UWB ,Physics ,QC1-999 ,Electricity and magnetism ,QC501-766 - Abstract
A high order multiple input multiple output (MIMO) antenna assembly is designed for Ultra-Wideband (UWB) applications. The antenna configuration is based on a peculiar arrangement of the radiating elements. A defected microstrip structure is also introduced on the feedlines. The use of a novel technique, the so-called ports-shift, is here discussed. In the proposed antenna, a protruded ground branch structure is employed in combination of three parasitic stubs so as to enhance isolation and impedance matching over the UWB frequency band. The results show that the presented antenna exhibits a good impedance matching which is about -10 dB with a high mutual coupling 15 dB, and envelope correlation coefficients (ECC) smaller than 0.15. The antenna also exhibits good diversity gain of about 9.5, and a good efficiency that varied between 56% and 91% and total active reflection coefficient of less than -20 dB. Which makes it a good candidate for UWB applications.
- Published
- 2020
- Full Text
- View/download PDF
5. Mutual Coupling Reduction Using a Protruded Ground Branch Structure in a Compact UWB Owl-Shaped MIMO Antenna
- Author
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A. Mchbal, N. Amar Touhami, H. Elftouh, and A. Dkiouak
- Subjects
Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Cellular telephone services industry. Wireless telephone industry ,HE9713-9715 - Abstract
A compact ultra-wideband (UWB) multiple input-multiple output (MIMO) antenna with high isolation is designed for UWB applications. The proposed MIMO antenna consists of two identical monopole antenna elements. To enhance the impedance matching, three slots are formed on the ground plane. The arc structure as well as the semicircle with an open-end slot is employed on the radiating elements the fact which helps to extend the impedance bandwidth of the monopole antenna from 3.1 up to 10.6 GHz, which corresponds to the UWB band. A ground branch decoupling structure is introduced between the two elements to reduce the mutual coupling. Simulation and measurement results show a bandwidth range from 3.1 to 11.12 GHz with |S11_|
- Published
- 2018
- Full Text
- View/download PDF
6. Circular Planar Antenna with Reconfigurable Radiation Pattern using PIN Diodes
- Author
-
Rahmani, F., Touhami, N. Amar, Kchairi, A. Belbachir, and Taher, N.
- Published
- 2020
- Full Text
- View/download PDF
7. Viscous Dissipation and Radiation Effects on MHD Heat Transfer Flow of Casson Fluid Through a Moving Wedge with Convective Boundary Condition in the Existence of Internal Heat Generation/Absorption
- Author
-
N. Amar, N. Kishan, and B. Shankar Goud
- Subjects
Fluid Flow and Transfer Processes ,Mechanical Engineering - Abstract
In this investigation the problem of study is the impacts of viscous dissipation, thermal radiation on the MHD heat transfer flow of Casson fluid across a moving wedge with convective boundary condition in the existence of and internal heat generation/absorption. The governing equations are changed to some coupled differential equations which are not nonlinear with aid of similarity variable. The numerical calculations of the equations are elucidated by the MATLAB package solver bvp5c. The changes of the pertinent constraints on the momentum and temperature have been discussed through graphs and numerical values of skin friction and heat transfer factor are listed in the tabular pattern. The velocity increases and the temperature decreases as λ > 1 increases in the instance λ, also temperature increases with an increase of Radiation parameter.
- Published
- 2023
8. Particle SWARM Optimization for X-BAND Frequency-Reconfigurable SIW Antenna Using Integrated PIN Diode Switches.
- Author
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El khamlichi, D., Elhamadi, T., Touhami, N. Amar, Ben Haddi, S., and Taher, N.
- Subjects
PARTICLE swarm optimization ,ANTENNAS (Electronics) ,ANTENNA design ,BROADBAND antennas ,COST functions - Abstract
This paper presents an optimal structure of a frequency-reconfigurable SIW antenna, where reconfigurability is achieved using PIN diodes. The antenna is optimized using the PSO (Particle Swarm Optimization) algorithm implemented and developed in MATLAB. The antenna is based on Substrate Integrated Waveguide technology, comprising three slot resonators positioned at the bottom of the SIW antenna. PIN diodes are placed on the structure's feed line to modify the antenna's resonant frequency, making it usable on different Xband frequencies. The PSO algorithm aims to determine the optimum position of the PIN diodes and the size of each slot according to the state of the PIN diode (ON or OFF). The optimized reconfigurable SIW antenna is designed, manufactured, and measured to operate over different frequency bands depending on the diode bias state. Measured gain reaches maximum values of 8.6 dB, 9.4 dB, 9.2 dB and 8.8 dB respectively for OFF-OFF, OFF-ON, ON-OFF and ON-ON bias states. [ABSTRACT FROM AUTHOR]
- Published
- 2024
9. MHD heat transfer flow over a moving wedge with convective boundary conditions with the influence of viscous dissipation and internal heat generation/absorption
- Author
-
N. Amar, N. Kishan, and B. Shankar Goud
- Subjects
Fluid Flow and Transfer Processes ,Condensed Matter Physics - Published
- 2022
10. Computational Solution of Two–Point Boundary Value Problems with Derivative Boundary Conditions using Cubic-Spline Process
- Author
-
Tjprc and N. Amar Nath N. Amar Nath
- Subjects
Fluid Flow and Transfer Processes ,Point boundary ,Mechanical Engineering ,Mathematical analysis ,Process (computing) ,Aerospace Engineering ,Boundary value problem ,Derivative ,Value (mathematics) ,Mathematics - Published
- 2020
11. Viscous Dissipation and Heat Transfer Effect on MHD Boundary Layer flow past a Wedge of Nano fluid Embedded in a Porous media
- Author
-
N. Amar
- Subjects
Materials science ,Partial differential equation ,General Mathematics ,Laminar flow ,Mechanics ,Thermophoresis ,Education ,Computational Mathematics ,Boundary layer ,Nanofluid ,Computational Theory and Mathematics ,Flow (mathematics) ,Heat transfer ,Magnetohydrodynamic drive - Abstract
In this investigation the steady of laminar magnetohydrodynamic(MHD) heat and mass transfer two dimensional boundary layer nanofluid flow past a wedge embedded in a porous media in the availability of the viscous dissipation, thermophoresis and Brownian motion effects are taken into account. With the assistance of the similarity transformation, the governing partial differential equations (PDE) are transformed into nonlinear ordinary differential equations (ODE). The solution of the problem is solved numerically by using the MATLAB in built package solver bvp4c. The method's accuracy is examined against recently discussed results and outstanding agreement was reached. The impacts of the pertinent flow parameters are examined through graphs and tabular form.
- Published
- 2021
12. HEAT AND MASS TRANSFER ANALYSIS OF CASSON FLUID FLOW OVER A MOVING WEDGE FILLED WITH NANOFLUID
- Author
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N. Amar and Naikoti Kishan
- Subjects
business.product_category ,Nanofluid ,Materials science ,Flow (mathematics) ,General Mathematics ,Mass transfer ,Casson fluid ,Mechanics ,business ,Wedge (mechanical device) - Published
- 2021
13. Pico-Light H2O: intercomparison of in situ water vapour measurements during the AsA 2022 campaign
- Author
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M. Ghysels, G. Durry, N. Amarouche, D. Hurst, E. Hall, K. Xiong, J.-C. Dupont, J.-C. Samake, F. Frérot, R. Bejjani, and E. D. Riviere
- Subjects
Environmental engineering ,TA170-171 ,Earthwork. Foundations ,TA715-787 - Abstract
The mid-infrared lightweight tunable diode laser hygrometer, “Pico-Light H2O”, the successor to Pico-SDLA H2O, is presented and its performances are evaluated during the AsA 2022 balloon-borne intercomparison campaign conducted at the CNES Aire-sur-l'Adour (AsA, 43.70° N; 0.25° W) balloon launch facility and the Aeroclub d'Aire-sur-l'Adour in France. The Pico-Light instrument has primarily been developed for sounding of the upper troposphere and stratosphere, although during the AsA 2022 campaign we expand the range of comparison to include additionally the lower troposphere. Three different types of hygrometer and two models of radiosonde were flown, operated by the French Space Agency (CNES) and the NOAA Global Monitoring Laboratory (GML) scientific teams: Pico-Light H2O, the NOAA Frost Point Hygrometer (FPH), the micro-hygrometer (in an early phase of development), and M20 and iMet-4 sondes. Within this framework, we intend to validate measurements of Pico-Light H2O through a first intercomparison with the NOAA FPH instrument. The in situ monitoring of water vapour in the upper troposphere–lower stratosphere continues to be very challenging from an instrumental point of view because of the very small amounts of water vapour to be measured in these regions of the atmosphere. Between the lapse rate tropopause (11–12.3 km) and 20 km, the mean relative difference between water vapour mixing ratio measurements by Pico-Light H2O and NOAA FPH was 4.2 % ± 7.7 %, and the mean tropospheric difference was 3.84 % ± 23.64 %, with differences depending on the altitude range considered. In the troposphere, relative humidity (RH) over water comparisons led to agreement between Pico-Light and NOAA FPH of −0.2 % on average, with excursions of about 30 % RH due to moisture variability. Expanding the comparison to meteorological sondes, the iMet-4 sondes agree well with both Pico-Light and FPH between the ground and 7.5 km (within ± 3 % RH), as do the M20 sondes, up to 13 km, which are wet-biased by 3 % RH and dry-biased by 20 % in cases of saturation.
- Published
- 2024
- Full Text
- View/download PDF
14. Isolation Enhancement Using a Hybrid Technique in an Eight-Element UWB MIMO Antenna Design
- Author
-
N. Amar Touhami, Hanae Elftouh, Aicha Mchbal, and Aziz Dkiouak
- Subjects
lcsh:QC501-766 ,Physics ,Coupling ,0303 health sciences ,Radiation ,030306 microbiology ,Frequency band ,Acoustics ,mutual coupling ,MIMO ,Impedance matching ,lcsh:QC1-999 ,Microstrip ,Diversity techniques ,Electronic, Optical and Magnetic Materials ,03 medical and health sciences ,UWB ,Diversity gain ,lcsh:Electricity and magnetism ,Electrical and Electronic Engineering ,Antenna (radio) ,Reflection coefficient ,lcsh:Physics - Abstract
A high order multiple input multiple output (MIMO) antenna assembly is designed for Ultra-Wideband (UWB) applications. The antenna configuration is based on a peculiar arrangement of the radiating elements. A defected microstrip structure is also introduced on the feedlines. The use of a novel technique, the so-called ports-shift, is here discussed. In the proposed antenna, a protruded ground branch structure is employed in combination of three parasitic stubs so as to enhance isolation and impedance matching over the UWB frequency band. The results show that the presented antenna exhibits a good impedance matching which is about -10 dB with a high mutual coupling 15 dB, and envelope correlation coefficients (ECC) smaller than 0.15. The antenna also exhibits good diversity gain of about 9.5, and a good efficiency that varied between 56% and 91% and total active reflection coefficient of less than -20 dB. Which makes it a good candidate for UWB applications.
- Published
- 2020
15. Circular Planar Antenna with Reconfigurable Radiation Pattern using PIN Diodes
- Author
-
Nihade Taher, Faouzi Rahmani, A. Belbachir Kchairi, and N. Amar Touhami
- Subjects
Physics ,0209 industrial biotechnology ,business.industry ,Main lobe ,PIN diode ,02 engineering and technology ,Radiation ,Industrial and Manufacturing Engineering ,law.invention ,Radiation pattern ,020303 mechanical engineering & transports ,020901 industrial engineering & automation ,Optics ,0203 mechanical engineering ,Interference (communication) ,Artificial Intelligence ,law ,Antenna (radio) ,business ,Short circuit ,Beam (structure) - Abstract
This work presents a circular planar antenna with reconfigurable radiation pattern using parasitic patches. The radiation pattern of the proposed antenna may take different radiation modes. The mode change is made using the PIN diodes connected in the gap between the central circular patch and the parasitic patches. A short circuit or an open circuit can be provided by this gap. The proposed antenna works at 5 GHz, such as 802.11a/d/n applications. The goal is to provide wider coverage by redirecting the main lobe and controlling the main beam directions to avoid interference with surrounding signals.
- Published
- 2020
16. The influence of radiation on MHD boundary layer flow past a nano fluid wedge embedded in porous media
- Author
-
Naikoti Kishan and N. Amar
- Subjects
T57-57.97 ,Materials science ,Radiation ,Applied mathematics. Quantitative methods ,MHD ,Viscous dissipation ,bvp4c ,Laminar flow ,Mechanics ,Nanofluid ,Wedge ,Thermophoresis ,Physics::Fluid Dynamics ,Boundary layer ,Viscosity ,Flow (mathematics) ,Magnetohydrodynamics ,Porous medium - Abstract
This study takes into account the viscous dissipation of the laminar viscosity and radiation influence of the MHD heat and mass transfer nanofluid flow across two dimensional boundary layers in the porous medium in the existence of heat, thermophoresis and Brownian motion influence. The governing equations are transformed into nonlinear ordinary differential equations by the aid of the similarity transformation. The solution is numerically solved with the MATLAB in the built-in bvp4c solver. The influences of the appropriate flow parameters are analysed in graphs and in tabular form.
- Published
- 2021
17. Modeling a Planar Coupled Microstrip Lines using various Wavelets and Method of Moments
- Author
-
Mohamed Bayjja, Gamil Alsharahi, Mohamed Aghoutane, Mahmoud Moubadir, and N. Amar Touhami
- Subjects
lcsh:QC501-766 ,Physics ,0303 health sciences ,Radiation ,030306 microbiology ,Mathematical analysis ,Coupled Microstrip Lines, Methods of moments, Wavelets, Sparse matrix, and CPU Time ,Basis function ,Method of moments (statistics) ,Impedance parameters ,lcsh:QC1-999 ,Microstrip ,Electronic, Optical and Magnetic Materials ,03 medical and health sciences ,Coiflet ,Wavelet ,lcsh:Electricity and magnetism ,Electrical and Electronic Engineering ,lcsh:Physics ,Coupling coefficient of resonators ,Sparse matrix - Abstract
In this paper, we apply a several wavelets basis functions to the method of moments to modeling the parallel-coupled microstrip lines. The first set of equations is for the shielded microstrip line solved with moment’s method and wavelets. The Green’s function is obtained from the theory of images. The second set are for the parallel-coupled microstrip lines operating in the TEM mode or when the analysis can be based on quasi-static approximation, the properties of coupled lines can be determined from the self- and mutual inductances and capacitances for the lines. To demonstrate the effectiveness and accuracy of the proposed technique, numerical results of even- and odd-mode characteristic impedances, coupling coefficient, percentage sparsity achieved in the impedance matrix, the CPU Time to reverse impedance matrix, and error relative for Daubechies, Coiflets, Biorthogonal and Symlets wavelets are presented. Numerical results are in good agreement with those in previous publications.
- Published
- 2019
18. Viscous Dissipation and Heat Transfer Effect on MHD Boundary Layer flow past a Wedge of Nano fluid Embedded in a Porous media
- Author
-
Et. al., N. Amar,, primary
- Published
- 2021
- Full Text
- View/download PDF
19. Reconfigurable Radiation Pattern Antenna with eight Switchable Beams in Azimuth Plane for WLAN Wireless System
- Author
-
Faouzi Rahmani, N. Amar Touhami, Abdemounaim Belbachir Kchairi, and Nihade Taher
- Subjects
Physics ,0209 industrial biotechnology ,Reconfigurable antenna ,business.industry ,Coaxial cable ,Bandwidth (signal processing) ,PIN diode ,020206 networking & telecommunications ,02 engineering and technology ,law.invention ,Radiation pattern ,Azimuth ,020901 industrial engineering & automation ,Optics ,Planar ,law ,0202 electrical engineering, electronic engineering, information engineering ,business ,Beam (structure) - Abstract
This work presents a reconfigurable radiation pattern antenna for WLAN wireless system. The reconfigurable antenna is fed by a coaxial cable, and consists of a star patch, eight hexagon-shaped radiation cells and a circular planar ground. The pattern-reconfigurable antenna proposed achieves eight reconfigurable states by controlling the ON and OFF of eight PIN diodes to change the direction. The state change is performed by PIN diodes connected in the gap between the central star patch and the radiation cells. The antenna has a bandwidth of 360 MHz and can steer the beam in the direction 20°, 340° in azimuth plane. The antenna main beam can be switched to eight directions in elevation plane. The simulated results are also presented and investigated.
- Published
- 2020
20. Mutual Coupling Reduction Using a Protruded Ground Branch Structure in a Compact UWB Owl-Shaped MIMO Antenna
- Author
-
N. Amar Touhami, Hanae Elftouh, Aicha Mchbal, and Aziz Dkiouak
- Subjects
Physics ,Article Subject ,020208 electrical & electronic engineering ,Bandwidth (signal processing) ,MIMO ,Impedance matching ,Mimo antenna ,020206 networking & telecommunications ,02 engineering and technology ,lcsh:HE9713-9715 ,Topology ,0202 electrical engineering, electronic engineering, information engineering ,lcsh:Cellular telephone services industry. Wireless telephone industry ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Electrical and Electronic Engineering ,Branch structure ,lcsh:TK1-9971 ,Monopole antenna ,Decoupling (electronics) ,Computer Science::Information Theory ,Ground plane - Abstract
A compact ultra-wideband (UWB) multiple input-multiple output (MIMO) antenna with high isolation is designed for UWB applications. The proposed MIMO antenna consists of two identical monopole antenna elements. To enhance the impedance matching, three slots are formed on the ground plane. The arc structure as well as the semicircle with an open-end slot is employed on the radiating elements the fact which helps to extend the impedance bandwidth of the monopole antenna from 3.1 up to 10.6 GHz, which corresponds to the UWB band. A ground branch decoupling structure is introduced between the two elements to reduce the mutual coupling. Simulation and measurement results show a bandwidth range from 3.1 to 11.12 GHz with |S11_|S21_
- Published
- 2018
21. Plant diseases of international importance
- Author
-
Kumar, Jatinder, Mukhopadhyay, A. N. (Amar Nath), 1940, Internet Archive, Kumar, Jatinder, and Mukhopadhyay, A. N. (Amar Nath), 1940
- Subjects
Plant diseases - Published
- 1900
22. Isolation Enhancement Using a Hybrid Technique in an Eight-Element UWB MIMO Antenna Design
- Author
-
Mchbal, A., primary, Touhami, N. Amar, additional, Elftouh, H., additional, and Dkiouak, A., additional
- Published
- 2020
- Full Text
- View/download PDF
23. Plant diseases of international importance
- Author
-
Kumar, Jatinder, Mukhopadhyay, A. N. (Amar Nath), 1940, Internet Archive, Kumar, Jatinder, and Mukhopadhyay, A. N. (Amar Nath), 1940
- Subjects
Plant diseases
24. Reconfigurable Radiation Pattern Antenna with eight Switchable Beams in Azimuth Plane for WLAN Wireless System
- Author
-
Rahmani, Faouzi, primary, Touhami, N. Amar, additional, Taher, Nihade, additional, and Kchairi, Abdemounaim Belbachir, additional
- Published
- 2020
- Full Text
- View/download PDF
25. The anatomical variations that occur in the great saphenous vein encounter during surgery -A study done at a tertiary care teaching hospital
- Author
-
D N, Amar, primary, R Bhat, Rashmi, additional, and K S, Satheesha, additional
- Published
- 2019
- Full Text
- View/download PDF
26. Evaluation of the ESBLN nerve variations that occur during thyroidectomy
- Author
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D N, Amar, primary, R Bhat, Rashmi, additional, and K S, Satheesha, additional
- Published
- 2019
- Full Text
- View/download PDF
27. Design at 2.4GHz Low Noise Amplifier for Wifi-Application
- Author
-
N. Amar Touhami, M. El Bakkali, and Taj-eddin Elhamadi
- Subjects
Physics ,business.industry ,Frequency band ,Amplifier ,Transistor ,Electrical engineering ,Impedance matching ,Noise figure ,Low-noise amplifier ,law.invention ,law ,Reflection (physics) ,Wireless ,business - Abstract
This This paper presents a low noise amplifier (LNA) for WLAN applications. The target frequency band 802.11b/g@ 2.4GHz. The amplifier is characterized by input and output reflection coefficients less than −15dB, a forward gain (S21) of 15.112dB, a noise figure of 0.37dB and the third input intercept point of 14.8dB.
- Published
- 2019
28. Analysis of Series and Shunt Rectifier Circuits Topologies
- Author
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M. El Bakkali, N. Amar Touhami, Intissar Hamzi, and Mohamed Aghoutane
- Subjects
business.industry ,Computer science ,Schottky diode ,020206 networking & telecommunications ,Hardware_PERFORMANCEANDRELIABILITY ,02 engineering and technology ,Network topology ,Power level ,Software ,0202 electrical engineering, electronic engineering, information engineering ,Electronic engineering ,Wireless ,business ,Electrical efficiency ,Shunt (electrical) ,Electronic circuit - Abstract
This paper presents the analysis of RF-DC conversion circuit topologies designed for wireless energy harvesting at 2.45 Ghz. two rectifications circuits are studied, designed and compared at the conversion power level. The power efficiency of the series and shunt topology are 70% and 74% respectively at the 2.45Ghz frequency. these topologies have been studies and their performances have been evaluated. The simulation results of rectifier circuit are obtained using Advanced Design System-ADS Software.
- Published
- 2019
29. Electronically tunable phase shifter with enhanced phase behaviour at Ku Band
- Author
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Pablo Padilla, Juan F. Valenzuela-Valdes, Antonio Palomares, N. Amar Touhami, M. Taha El Khorassani, and M.A. Vaquero
- Subjects
Materials science ,business.industry ,Phase (waves) ,Optoelectronics ,business ,Phase shift module ,Ku band - Published
- 2018
30. Giant solitary trichoepithelioma
- Author
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D N Amar, R Santhosh, P B Thrishuli, Shravan Rajpurohit, and Bhavuray Teli
- Subjects
Cancer Research ,medicine.medical_specialty ,business.industry ,Standard treatment ,Brooke-Spiegel syndrome ,Review Article ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Dermatology ,lcsh:RC254-282 ,trichogenic tumor ,Review article ,Adnexal tumors ,Surgery ,Rare tumor ,Oncology ,medicine ,Rombo syndrome ,Surgical excision ,Basal cell carcinoma ,giant solitary trichoepithelioma ,business ,Giant solitary trichoepithelioma - Abstract
Adnexal tumors like giant solitary trichoepitheliomas are uncommon to most of us to permit a ready familiarity with them. Information regarding the genesis, clinical profile, behavior, and management options for this tumor is limited. There are 18 cases reported in the world literature till date. This review attempts to provide insight to this rare tumor. Our search included indexed literature from Pubmed, Directory of Open Access Journals, Health Inter Network Access to Research Initiative and Google databases in addition to standard dermatology texts. Giant solitary trichoepithelioma is a rare trichogenic tumor with potential for local recurrence. It has predilection for the older age, but may present at any age including at birth. It has close resemblance to basal cell carcinoma and other skin adnexal tumors - clinically, cytologically, and histologically. CD10, CD 34, PHLDA1 but not p75NTR are useful adjunct markers. Surgical excision is the standard treatment. Recurrence and possible transformation into BCC cautions follow up at regular intervals.
- Published
- 2015
31. Contribution to the two-dimensional modeling of micro-coplanar lines on a dielectric substrate
- Author
-
Acheghaf, A., primary, Boussouis, M., additional, and Touhami, N. Amar, additional
- Published
- 2017
- Full Text
- View/download PDF
32. Apport de la microscopie confocale in vivo dans les formes invasives de néoplasie malpighienne de la surface oculaire: à propos d’un cas
- Author
-
Emmanuelle Brasnu, R. Tahiri Joutei Hassani, M. Sterkers, Antoine Labbé, C. Baudouin, L. Gheck, and N. Amar
- Subjects
Gynecology ,Ophthalmology ,medicine.medical_specialty ,Epidermoid carcinoma ,business.industry ,In vivo confocal microscopy ,Medicine ,business - Abstract
Resume Introduction La neoplasie malpighienne de la surface oculaire est la cause la plus frequente des tumeurs conjonctivo-limbiques malignes. Son aspect clinique precoce peut parfois etre atypique, et confondu avec celui d’un pterygion. Observation Nous rapportons l’observation d’une femme ayant presente une volumineuse tumeur conjonctivo-limbique initialement etiquetee pterygion pour laquelle un examen en microscopie confocale in vivo a ete realise. Cet examen a permis de mettre en evidence des elements en faveur d’une neoplasie malpighienne de la surface oculaire de type invasive ou carcinome epidermoide, diagnostic fortement suspecte par l’examen clinique et confirme ensuite par l’examen anatomopathologique de la piece d’exerese chirurgicale. Conclusion Cette observation souligne l’interet de la microscopie confocale in vivo pour le diagnostic des tumeurs conjonctivo-limbiques malignes, examen qui peut etre une aide au diagnostic differentiel entre tumeurs malignes debutantes et pterygion.
- Published
- 2010
33. Étude pilote d’un nouvel agent de thérapie matricielle (RGTA OTR4120®) dans les ulcères de cornée et les dystrophies cornéennes rebelles
- Author
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Denis Barritault, K. Kichenin, H. Nourry, Jean-Michel Warnet, Christophe Baudouin, N. Amar, and C. Khammari Chebbi
- Subjects
Gynecology ,Ophthalmology ,medicine.medical_specialty ,business.industry ,Heparitin Sulfate ,medicine ,business - Abstract
Objectif : Etude pilote exploratrice a usage compassionnel, non controlee, visant a evaluer la tolerance et l'efficacite d'une nouvelle solution ophtalmique a base d'agents de regeneration, analogues des heparanes sulfates (RGTAs) dans les ulceres de cornee et les dystrophies corneennes chroniques severes resistantes aux traitements usuels. Rationnel : Les RGTAs sont des biopolymeres de grande taille concus pour remplacer les heparanes sulfates lies specifiquement aux proteines de la matrice et aux facteurs de croissance mais detruits lors de lesions tissulaires. Les proteines fixees sur le RGTA sont alors protegees contre une proteolyse, ce qui permet de restaurer le microenvironnement de la matrice extracellulaire. Les signaux endogenes necessaires au renouvellement cellulaire qui assurent localement l'homeostasie tissulaire sont a nouveau en place sur la matrice restauree pour declencher la bonne sequence spatio-temporelle de migration et de multiplication cellulaire. La therapie matricielle par le RGTA represente une alternative aux therapies geniques ou cellulaires proposees en medecine regenerative. Dans un modele pre-clinique d'ulceration severe de cornee induite par base chez le lapin, une seule instillation avait ete suffisante pour augmenter fortement la vitesse et la qualite de la cicatrisation et permettre apres seulement une semaine une restauration de la cornee d'une qualite histologique presque normale. Ce sont ces resultats qui nous ont pousses a entreprendre cette premiere etude clinique dont le but principal etait d'evaluer la tolerance locale de cette preparation. Patients et methodes : Onze yeux de dix patients ont ete inclus dans l'etude. Tous les patients avaient des dystrophies corneennes severes ou des ulceres corneens douloureux, avec des douleurs cotees au moins 50 sur une echelle visuelle analogique (EVA) notee de 0 a 100, et en echec de traitement. La solution oculaire a base de RGTA a ete instillee par l'investigateur en consultation a raison d'une goutte hebdomadaire pendant un mois. La tolerance et l'efficacite ont ete jugees sur des criteres subjectifs bases essentiellement sur l'appreciation de la douleur et de la gene fonctionnelle et sur des criteres objectifs cliniques lors d'un examen ophtalmologique complet a J3, J7, J14, J21, J28 puis a 2 mois et 3 mois du debut du traitement. Resultats : L'etude a pu etre menee a terme chez tous les patients inclus au depart. La tolerance etait excellente sur le plan local et general: pas de gene a l'instillation, pas d'aggravation de la pathologie initiale, d'apparition d'inflammation oculaire ou d'augmentation de la tension oculaire, et pas d'effets adverses generaux. Par ailleurs, on a observe un effet antalgique notable rapide augmentant au fil des instillations avec un retour des douleurs dans la majorite des cas apres arret du traitement. Le score d'EVA a l'inclusion etait de 72,73 ± 7,86, il a baisse de facon significative des la premiere administration du traitement. A un mois, le score d'EVA moyen etait de 32 ± 15,49 puis il est remonte a l'arret du traitement renforcant ainsi l'hypothese d'un lien entre les effets observes et l'application du produit. L'efficacite sur la keratite a ete moderee mais avec une tendance generale vers l'amelioration apres l'instillation de la solution ophtalmique. Le score d'Oxford decrivant l'intensite de la keratite ponctuee superficielle etait de 3,37 ± 1,06 a l'inclusion. Apres un mois il etait de 1,57 ± 0,97, il a donc baisse de facon significative au cours du traitement. Sur les cinq cas inclus d'ulceres de cornee, quatre ont cicatrise au cours du protocole. Deux ont recidive des l'arret du traitement, deux ont cicatrise sans recidive au dernier controle. Le dernier cas etait caracterise par une insuffisance limbique et aucune amelioration n'a ete notee. Il est important de rappeler ici que ces ulceres etaient resistants a toutes les therapeutiques usuelles. Conclusion: Cette nouvelle solution ophtalmique a base de RGTA utilisee dans les dystrophies corneennes chroniques et les ulceres de cornee rebelles est tres bien toleree sur le plan local et general. Elle diminue les douleurs de facon significative et favoriserait la cicatrisation corneenne dans certains cas. Toutefois l'instillation hebdomadaire d'une goutte peut sembler insuffisante et ces premiers resultats prometteurs meritent d'etre etayes par des etudes plus larges, controlees et des posologies mieux adaptees.
- Published
- 2008
34. Apport de la microscopie confocale in vivo à l’étude des ptérygions
- Author
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N. Amar, Christophe Baudouin, L. Gheck, Eric Denion, and B. Dupas
- Subjects
Physics ,Ophthalmology ,Confocal microscopy ,law ,In vivo confocal microscopy ,Molecular biology ,law.invention - Abstract
But Decrire la structure et l’aspect tissulaire in vivo du pterygion a l’aide d’un microscope confocal de nouvelle generation (Heidelberg Retina Tomograph II Rostock Cornea Module) et montrer les elements caracteristiques des pterygions actifs. Patients et methode Nous avons analyse au biomicroscope et au microscope confocal 20 pterygions de 15 patients. Aucun de ces patients n’avait ete opere de pterygion. Resultats La microscopie confocale a permis de realiser in vivo des coupes optiques de haute resolution. Nous avons pu identifier l’epithelium conjonctival recouvrant le pterygion avec son bourrelet peripherique, le stroma pterygial avec sa vascularisation, les ilots et la zone progressive de Fuchs, et les cellules dendritiques qui etaient d’autant plus nombreuses que le pterygion etait actif. Discussion L’analyse de la structure et de l’histologie du pterygion a ete l’objet de nombreuses publications. La microscopie confocale en mode HRT-II permet une nouvelle approche in vivo de cette pathologie et permet en particulier d’evaluer avec precision son caractere evolutif.
- Published
- 2007
35. Paediatric procedural sedation - a review and an update
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Rebecca Jacob, K Ilamurugu, and N Amar
- Subjects
lcsh:RD78.3-87.3 ,Analgesia ,Paediatrics ,lcsh:Anesthesiology ,Procedural sedation ,Safety guidelines - Abstract
Sedation and analgesia are frequently administered to paediatric patients for procedures done outside the operating room. Both diagnostic and therapeutic procedures are now being increasingly done outside the oper-ating room partly due to time constraints, partly in an effort to decrease cost and partly due to fear of compli-cations of sedation. So children are often subjected to sedation by unskilled personnel with little or no training in resuscitation. In other cases children who would have benefited by sedation are being denied sedation and/ or left with long term psychological scars. The fear of undergoing a painful procedure or a procedure in unfamiliar surroundings remains considerably high. This is especially true in young children and mentally handicapped children. The whole issue is compounded by parental anxiety, separation from parents and pain or anticipation of pain during the procedure. It is poorly understood that procedures done outside the operat-ing room require the same attention to anxiolysis, analgesia, sedation and safety guidelines as procedures performed in the operating room. To this end we require appropriate definitions, goals, guidelines, monitoring and adequately trained personnel. In this review and update we have examined the international guidelines, looked at the drugs which may be used, and safety constraints. We also have enunciated guidelines for proce-dural sedation in children which may be adapted to the Indian scenario.
- Published
- 2007
36. Contribution to the two-dimensional modeling of micro-coplanar lines on a dielectric substrate.
- Author
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Acheghaf, A., Boussouis, M., and Touhami, N. Amar
- Published
- 2017
- Full Text
- View/download PDF
37. Design of a compact CPW ultra-wideband antenna
- Author
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Mohammad Essaaidi, N. Amar Touhami, and A. Zakriti
- Subjects
Reconfigurable antenna ,Coaxial antenna ,Computer science ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Antenna measurement ,Data_CODINGANDINFORMATIONTHEORY ,Antenna efficiency ,Radiation pattern ,law.invention ,Hardware_GENERAL ,law ,Electronic engineering ,Dipole antenna ,Omnidirectional antenna ,Monopole antenna - Abstract
In this paper, a design and analysis of compact coplanar waveguide-fed ultra wideband antenna is presented. The antenna design exhibits a very wide operating bandwidth of 14.3GHz with a return loss better than 10dB in the frequency range from 3.7GHz to 18GHz. The gain of the proposed antenna is around 4.8dBi. This antenna configuration would be useful for UWB indoor application as it is easy to fabricate and integrate with RF circuitry. All simulations in this work were carried out by using the electromagnetic software.
- Published
- 2014
38. Microscopie confocale et pathologies de la surface oculaire : corrélations anatomo-cliniques
- Author
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N. Amar, Antoine Labbé, Christophe Baudouin, R. De Nicola, and B. Dupas
- Subjects
Ophthalmology ,business.industry ,Medicine ,KERATOCONJUNCTIVITIS SICCA ,Impression cytology ,business ,Molecular biology - Abstract
Objectifs Etudier la precision anatomo-clinique des atteintes epitheliales corneo-conjonctivales au cours de diverses pathologies de la surface oculaire analysees in vivo a l’aided’un microscope confocal de nouvelle generation (Heidelberg Retina Tomograph II [HRT] Rostock Cornea Module), et comparer ces resultats avec ceux obtenus en immunocytochimie sur empreinte corneenne ou conjonctivale. Patients et methodes Trente-six yeux de 18 patients, presentant des pathologies de la surface oculaire diagnostiquees cliniquement, ont ete examines : epitheliopathie corneenne secondaire a une rosacee oculaire (5 patients) ; syndromes secs par deficit lacrymal dans le cadre d’un syndrome de Gougerot-Sjogren (5 patients), ou par hyperevaporation secondaire a un dysfonctionnement meibomien (8 patients). Les 18 patients ont beneficie d’une etude au biomicroscope, au microscope confocal puis d’une empreinte corneenne et/ou conjonctivale realisee sur le meme site d’examen. Les parametres au cours de cette etude ont inclus au niveau corneen et conjonctival : la morphologie epitheliale a l’echelle cellulaire ; la densite en cellules a mucus et leur eventuelle presence dans l’epithelium corneen ou au limbe ; la presence et la densite de cellules inflammatoires. Resultats Le microscope confocal a permis de realiser in vivo des coupes optiques de haute resolution de toute la surface oculaire. Cet examen a objective, a une echelle cellulaire, les modifications importantes de la surface oculaire lors des keratoconjonctivites seches, confirmant la perte en cellules a mucus, la metaplasie squameuse epitheliale, les infiltrations de cellules inflammatoires et, meme dans certains cas, l’aspect de « snake-like chromatin » decrit jusqu’alors uniquement en histologie. Au cours des epitheliopathies corneennes secondaires a une rosacee oculaire, la conjonctivalisation de la couche corneenne epitheliale pouvait etre bien identifiee avec la presence de cellules a mucus et de cellules morphologiquement proches de l’epithelium conjonctival envahissant un epithelium corneen metaplasique. L’analyse comparative entre les images obtenues in vivo avec cet appareil et in vitro par immunocytochimie sur empreinte corneo-conjonctivale a mis en evidence une excellente correlation anatomo-clinique dans chaque cas. Conclusion La microscopie confocale HRT II in vivo permet l’etude precise de la cornee centrale, du limbe et de la conjonctive, contrairement aux premieres generations d’appareils. Les images realisees avec cet examen dans le cadre des pathologies de la surface oculaire presentent une excellente correlation anatomo-clinique. Ce strict reflet de l’architecture cellulaire, demontre in vitro sur empreintes corneo-conjonctivales, valide la qualite de resolution du microscope confocal et confirme le potentiel extremement prometteur de cette nouvelle technique d’exploration.
- Published
- 2005
39. Capture and dissipation in the superheavy region
- Author
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I. V. Pokrovsky, Th. Materna, Marian Jandel, C. Schmitt, J. Pe´ter, O. Dorvaux, I. M. Itkis, J. Kliman, E. M. Kozulin, Giorgio Giardina, Yoshihiro Aritomo, L. Stuttge, A. A. Bogatchev, G. Knyajeva, E. V. Prokhorova, V. Bouchat, S. Gre´vy, F. Hanappe, V. Voskresensky, N. A. Kondratiev, N. Amar, L. Krupa, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Recherches Subatomiques (IReS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Nuclear physics ,Physics ,Nuclear and High Energy Physics ,Neutron ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,Atomic physics ,Dissipation - Abstract
The competition between fusion-fission and quasi-fission in the reactions 48 Ca+ 208 Pb and 48 Ca+ 244 Pu(E * = 40MeV) is investigated using the pre-scission neutron multiciplicity distributions ( PSNMD ) obtained with a new analysis protocol.
- Published
- 2004
40. A Novel Blind Image Source Separation Using Hybrid Firefly Particle Swarm Optimization Algorithm
- Author
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A. Khalfa, M. Sahed, E. Kenane, and N. Amardjia
- Subjects
Blind Image Separation ,Hybrid Firefly Particle Swarm Optimization ,PSNR ,SSIM ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Technology (General) ,T1-995 ,Information technology ,T58.5-58.64 - Abstract
Signal and image separation are extensively used in numerous imaging applications and communication systems. In this paper, a novel Blind Source Separation (BSS) approach, based on the Hybrid Firefly Particle Swarm Optimization (HFPSO), is proposed for separating mixed images. This approach processes the observed source without any prior knowledge about the model and the statistics of the source signal. The proposed method presents high robustness against local minima and converges quickly to the global minimum. Via numerical simulations, the proposed approach is tested and validated in comparison with standard Particle Swarm Optimization (PSO), Robust Independent Component Analysis (RobustICA), and Artificial Bee Colony (ABC) algorithms. The obtained results show that the presented technique outperforms the existing ones in terms of quality of image separation, the Signal-to-Noise Ratio (PSNR), and Structural Similarity Index Measure (SSIM). Moreover, the obtained results demonstrate that our approach provides also promising results in image separation from noisy mixtures.
- Published
- 2022
- Full Text
- View/download PDF
41. Low-cost active transceiver for WLAN applications
- Author
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J. Rodriguez-Tellez, N. Amar, Lorena Cabria, Jose A. Garcia, and Antonio Tazón
- Subjects
Engineering ,Null (radio) ,Digital down converter ,business.industry ,Electrical engineering ,Data signal ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Wide area ,Electronic engineering ,Active antenna ,Electrical and Electronic Engineering ,Transceiver ,business ,Microwave ,Broadside - Abstract
In this article, a new low-cost active antenna for WLAN sensor applications is presented. The proposed system operates as a transceiver whereby the received coded data signal from the broadside direction is retransmitted over a wide area in other directions. This is performed so that a null response at the main pointing angle is maintained. It is formed by a three elements series array connected to high- performance FET-based down- and up-converters. The performance of the proposed architecture is verified using experimental results. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2882–2884, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24788
- Published
- 2009
42. Risk Factors of Crashes Involving Motorcycles in Sri Lanka
- Author
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N. Amarasingha
- Subjects
motorcycle crashes ,injury severity model ,motorcycle safety ,Transportation and communications ,HE1-9990 - Abstract
Motorcycle is among the most popular and important modes of land transportation in tropical developing countries like Sri Lanka. Yet, research on the effect of motorcycles on traffic safety in Sri Lanka is limited. Investigation of the risk factors and contributory causes of motorcycle crashes using data sourced from Police records was the objective of this research. Police-reported crash data in Sri Lanka contain details of crashes at all severity levels that got reported, together with their corresponding different conditions, including environment, roadway, rider, and vehicle characteristics, throughout the country. Investigating the odds-ratios, the risk factors for motorcycle crashes could be identified in developing the potential counter-measures to improve traffic safety. In Sri Lanka, during 2009-2013, more than 200,000 of motorcycle crashes have been reported. The predominant crash conditions associated with motorcycles were driving on rural roadways, during weekdays, and riding newer motorcycles. The odds-ratios indicated that riding a motorcycle on dry surface conditions, on urban roads, and using safety helmets would be much safer. The results of the study add new insights to the traffic safety literature in regard to improving road safety in Sri Lanka.
- Published
- 2021
- Full Text
- View/download PDF
43. Le Jeu
- Author
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N. Amar
- Published
- 2013
44. Nonsteroidal anti-inflammatory drug–induced colonic stricture: case report
- Author
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J. N. Amar, J. A. Brown, S. G. Bicknell, and B. A. M. Walker
- Subjects
Male ,medicine.medical_specialty ,Urology ,Indomethacin ,Gastroenterology ,Colonic Diseases ,Ileocecal valve ,Intussusception (medical disorder) ,Internal medicine ,medicine ,Humans ,Ascending colon ,Radiology, Nuclear Medicine and imaging ,Aged ,Ileocecal Valve ,Radiological and Ultrasound Technology ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Invagination ,General Medicine ,Hepatology ,medicine.disease ,digestive system diseases ,Radiography ,Bowel obstruction ,Stenosis ,medicine.anatomical_structure ,Complication ,business ,Intussusception - Abstract
Nonsteroidal anti-inflammatory drug-induced colonic strictures are uncommon and usually occur in the proximal ascending colon. We describe the progressive findings of nonsteroidal anti-inflammatory drug-induced strictures in the ascending colon and at the ileocecal valve with subsequent bowel obstruction secondary to intussusception.
- Published
- 2002
45. STUDY OF ASSOCIATION BETWEEN BEEDI AND CIGARETTE SMOKING, SOCIO - ECONOMIC STATUS IN THE ETIOLOGY OF THROMBO - ANGIITIS OBLITERANS
- Author
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Y, Rama Krishna, primary, D N, Amar, additional, Naik, Aravind, additional, and Aithal, Sathyamurthy, additional
- Published
- 2015
- Full Text
- View/download PDF
46. Design of a compact CPW ultra-wideband antenna
- Author
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Zakriti, A., primary, Essaaidi, M., additional, and Touhami, N. Amar, additional
- Published
- 2014
- Full Text
- View/download PDF
47. [Contribution of in vivo confocal microscopy to diagnosis of invasive ocular surface squamous neoplasia: a case report]
- Author
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R Tahiri Joutei, Hassani, E, Brasnu, N, Amar, L, Gheck, A, Labbé, M, Sterkers, and C, Baudouin
- Subjects
Microscopy, Confocal ,Biopsy ,Carcinoma, Squamous Cell ,Humans ,Conjunctival Neoplasms ,Female ,Diagnostic Errors ,Limbus Corneae ,Middle Aged ,Pterygium ,Magnetic Resonance Imaging ,Eye Enucleation ,Corneal Diseases - Abstract
Ocular surface squamous neoplasia (OSSN) is the most common conjunctival and limbic malignant tumor that could resemble a pterygium in the early phase of the disease.We report the case of a woman who presented with a limbic tumor of the left eye that was mistakenly diagnosed as a pterygium. An in vivo confocal microscopy examination using the HRTII Rostock Cornea Module and a surgical biopsy were performed. The in vivo confocal microscopy findings and the slit lamp examination showed characteristics that strongly supported the diagnosis of OSSN, and the histological examination of both biopsy and surgical exeresis (exenteration) confirmed the diagnosis of epidermoid carcinoma.This case report underlines the value of in vivo confocal microscopy in the diagnosis of OSSN, particularly epidermoid carcinoma. This device could be helpful for the early differential diagnosis with pterygium.
- Published
- 2009
48. Self-Reported Habitual Practices and Perceptions of Young Drivers in Sri Lanka
- Author
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N. Amarasingha and H.M.M. Firdhaws
- Subjects
inexperienced drivers ,driver perception ,driving practices ,road safety ,sri lanka ,Transportation and communications ,HE1-9990 - Abstract
Crashes on the road have become a significant socio-economic problem. Younger generations, who have lesser experience in driving, are at greater risks of facing road accidents. It is therefore important to identify driving practices and perceptions of young and inexperienced drivers at an early phase of exposure so that factors that improve safe driving can be identified. This study analysed 400 young and inexperienced drivers’ self-reported habitual practices and perceptions based on a questionnaire survey. The questionnaire focused on supervision of early driving, limitation made by parents, accident and traffic offenses by these youngsters as drivers as well as other habitual driving practices. Analyses were done using reliability statistics, inter-item correlation, likelihood ratio tests, and parameter estimates. The highest inter-item correlation value was 0.467 for the pair of overtaking vehicles in restricted areas and taking the chance to speed and run a yellow light when it is about to change to red. Driving after alcohol consumption, mobile phone usage, taking an illegal U-turn at restricted areas, non-use of signals when changing lanes and overtaking a slow driver from the left side were influenced non-use of seat-belts by young drivers. These habitual practices while driving highlighted the importance of early intervention to improve road safety. In conclusion, there is always one or more habitual driving practices that have affect the other driving habits of a young driver.
- Published
- 2021
- Full Text
- View/download PDF
49. DYNAMICS OF CAPTURE QUASIFISSION AND FUSION-FISSION COMPETITION
- Author
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G. Knyajeva, V. M. Voskresenski, V. Bouchat, Yu. Ts. Oganessian, F. Hanappe, L. Krupa, A. A. Bogatchev, E. V. Prokhorova, N. A. Kondratiev, I. V. Pokrovski, Marian Jandel, J. Kliman, L. Stuttge, Th. Materna, E. M. Kozulin, Yoshihiro Aritomo, I. M. Itkis, N. Rowley, O. Dorvaux, G. Giardina, S. Grévy, M. G. Itkis, N. Amar, J. Peter, and C. Schmitt
- Subjects
Nuclear physics ,Competition (economics) ,Physics ,Dynamics (mechanics) ,Fusion fission - Published
- 2008
50. [Pilot study of a new matrix therapy agent (RGTA OTR4120) in treatment-resistant corneal ulcers and corneal dystrophy]
- Author
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C Khammari, Chebbi, K, Kichenin, N, Amar, H, Nourry, J M, Warnet, D, Barritault, and C, Baudouin
- Subjects
Corneal Dystrophies, Hereditary ,Wound Healing ,Instillation, Drug ,Humans ,Pilot Projects ,Ophthalmic Solutions ,Corneal Ulcer ,Drug Administration Schedule - Abstract
This study's objective was to evaluate the tolerance and safety of a new ophthalmic solution based on ReGeneraTing agent (RGTA) technology in a pilot noncontrolled exploration on compassion use for corneal ulcers and severe chronic dystrophies resistant to the usual treatments.RGTAs are large biopolymers engineered to replace heparan sulfates specifically bound to matrix proteins and growth factors destroyed after a lesion has occurred. The RGTA-bound proteins are protected from proteolysis and this allows the extracellular matrix microenvironment to restore its original proper organization. The initial endogenous signals needed for tissues to regenerate are back on the restored matrix. They are expected to trigger the natural onset of events, signaling cells to migrate and multiply with the cascades and equilibrium found in tissue homeostasis. RGTA-induced matrix therapy is a possible alternative to cell or gene therapy in regenerative medicine. In a rabbit preclinical model of alkali-induced severe corneal ulcers, a single instillation of RGTA ophthalmic solution was found sufficient to enhance speed and quality of healing, restoring an almost normal corneal histology after only 1 week. These data prompted us to initiate this study.Eleven eyes from ten patients were included in this study. All patients had severe dystrophic cornea or painful corneal ulcers rated over 50 on the VAS pain scale ranging from 0 to 100 and had undergone unsuccessful treatments. The RGTA ophthalmic solution was administered by the investigator during each weekly consultation as a single drop over 1 month. Tolerance and efficacy were judged on subjective criteria based on pain evaluation and functional inconvenience as well as on objective clinical criteria through a complete ophthalmic examination at days 3, 7, 14, 21, 28 and after 2 and 3 months from the beginning of the treatment.The study was conducted to completion for all patients included at the beginning. Tolerance was excellent both locally and generally: no uneasiness during instillation, no worsening of the initial pathology, no occurrence of ocular inflammation or increase in ocular pressure, and no general side effects were observed. In addition, we observed a noticeable analgesic effect, increasing with time and instillations, but pain reappeared in the majority of cases as treatment ended. The mean visual analog scale pain score was 72.73 +/- 7.86, it decreased significantly with the first drops of treatment. After 1 month, the mean visual analog scale pain score was 32+/-15.49, then it increased after the end of the treatment, confirming the link between the effects observed and the treatment. Efficacy on keratitis was moderate but with an overall tendency toward improvement. The initial Oxford Score was 3.37 +/- 1.06. After 1 month, it decreased significantly to 1.57 +/- 0.97 and then it rose again after the end of the treatment. As for corneal ulcers, of the five cases included, four healed during the protocol. Two reversed when the treatment stopped, two healed without reversion at the last follow-up visit. The last case was characterized by stem cell deficiency and no improvement was noted. It is important to keep in mind that these ulcers were all resistant to usual therapies.This RGTA ophthalmic solution is the first matrix therapy product in ophthalmology. The RGTA OTR4120 was used in treating chronic and severe corneal dystrophies as well as corneal ulcers resistant to usual treatments. It was very well tolerated with no side effects. It significantly reduced pain and favored corneal healing in almost all corneal ulcers. Weekly instillation of a single drop seems insufficient and these very promising data need to be confirmed on a larger population in a controlled trial with more adapted dosages. Based on these preliminary data, a RGTA-based matrix therapy product may be a very innovative solution to unresolved pain and corneal surface healing problems.
- Published
- 2008
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