1. MIR-182 is a Tbx5 effector during heart development in zebrafish
- Author
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M. Baugmart, Letizia Pitto, Ryuichi Fukuda, Didier Y.R. Stainier, Francesco Russo, Cathy J. Hatcher, Deborah M. Garrity, Marco Groth, Laura H. Mariani, Monica Evangelista, Mario Pellegrino, N. Ahujah, Elena Guzzolino, Alberto Mercatanti, and Romina D'Aurizio
- Subjects
Pharmacology ,Heart development ,Physiology ,Effector ,Molecular Medicine ,bioinformatica ,Biology ,biology.organism_classification ,Zebrafish ,Cell biology - Abstract
MicroRNAs, small molecules of 22-25 nt, inhibit translation of target mRNAs and with transcription factors comprise two major layers of gene regulatory networks with strictly intercon- nected activities. Tbx5, a dosage sensitive gene, is a pivotal player involved in heart/limbs development and its mutations are responsi- ble of the Holt-Oram syndrome (HOS) in human, characterized by upper limb malformations and congenital heart defects (CHD)s both in morphology and electrophysiology.
- Published
- 2018
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