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MIR-182 is a Tbx5 effector during heart development in zebrafish
- Source :
- Vascular pharmacology, info:cnr-pdr/source/autori:Guzzolino E.; D'aurizio R.; Pellegrino M.; Garrity D.; Ahujah N.; Groth M.; Baugmart M.; Hatcher C.; Mercatanti A.; Mariani L.; Evangelista M.; Russo F.; Fukuda R.; Stainier D.; Pitto L./titolo:MIR-182 is a Tbx5 effector during heart development in zebrafish/doi:10.1016%2Fj.vph.2017.12.031/rivista:Vascular pharmacology (Print)/anno:2018/pagina_da:58/pagina_a:58/intervallo_pagine:58–58/volume:103
- Publication Year :
- 2018
- Publisher :
- Elsevier Science, New York, NY , Stati Uniti d'America, 2018.
-
Abstract
- MicroRNAs, small molecules of 22-25 nt, inhibit translation of target mRNAs and with transcription factors comprise two major layers of gene regulatory networks with strictly intercon- nected activities. Tbx5, a dosage sensitive gene, is a pivotal player involved in heart/limbs development and its mutations are responsi- ble of the Holt-Oram syndrome (HOS) in human, characterized by upper limb malformations and congenital heart defects (CHD)s both in morphology and electrophysiology.
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Vascular pharmacology, info:cnr-pdr/source/autori:Guzzolino E.; D'aurizio R.; Pellegrino M.; Garrity D.; Ahujah N.; Groth M.; Baugmart M.; Hatcher C.; Mercatanti A.; Mariani L.; Evangelista M.; Russo F.; Fukuda R.; Stainier D.; Pitto L./titolo:MIR-182 is a Tbx5 effector during heart development in zebrafish/doi:10.1016%2Fj.vph.2017.12.031/rivista:Vascular pharmacology (Print)/anno:2018/pagina_da:58/pagina_a:58/intervallo_pagine:58–58/volume:103
- Accession number :
- edsair.doi.dedup.....b1076d44811bde4502dde25cbda2835e
- Full Text :
- https://doi.org/10.1016/j.vph.2017.12.031