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1. Ethoxyacetic Acid and N-Ethoxyacetylglycine: Metabolites of Ethoxyethanol (Ethylcellosolve) in Rats

Author

Göran Steen, Jörgen Pedersen, and Anna-Karin Jönsson

Subjects
Pharmacology, Chromatography, Chemistry, Glycine, N-ethoxyacetylglycine, Acetates, Ethylcellosolve, Toxicology, Mass Spectrometry, Rats, Biochemistry, Ethoxyacetic acid, Solvents, Animals, Ethylene Glycols
Abstract

Ethoxyethanol (ethylcellosolve) was administered to rats by inhalation and by feeding per os. Two metabolites were detected and identified: ethoxyacetic acid and N-ethoxyacetylglycine. The identity of these metabolites was confirmed by synthesis of N-ethoxyacetylglycine methyl ester, ethoxyacetic acid being commercially available.

Published
2009
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