Ethoxyacetic Acid and N-Ethoxyacetylglycine: Metabolites of Ethoxyethanol (Ethylcellosolve) in Rats

Ethoxyethanol (ethylcellosolve) was administered to rats by inhalation and by feeding per os. Two metabolites were detected and identified: ethoxyacetic acid and N-ethoxyacetylglycine. The identity of these metabolites was confirmed by synthesis of N-ethoxyacetylglycine methyl ester, ethoxyacetic acid being commercially available.