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1. Enhanced electron transfer and lauric acid hydroxylation by site-directed mutagenesis of CYP119

Author

Koo, Laura S., Immoos, Chad E., Cohen, Michael S., Farmer, Patrick J., and Montellano, Paul R. Ortiz de

Subjects
Mutagenesis -- Chemical properties, Hydroxylation -- Analysis, Electron transport -- Analysis, Chemistry
Abstract

The study explains how CYP119 hydroxylates lauric acid in a reaction supported by putidaredoxin and putidaredoxin reductase. This helps to engineer the mutagenesis of the complementarity of the protein-protein interface.

Published
2002

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