Enhanced electron transfer and lauric acid hydroxylation by site-directed mutagenesis of CYP119

Authors :: Koo, Laura S.
Immoos, Chad E.
Cohen, Michael S.
Farmer, Patrick J.
Montellano, Paul R. Ortiz de
Source :: Journal of the American Chemical Society. May 22, 2002, Vol. 124 Issue 20, p5684, 8 p.
Publication Year :: 2002
Abstract: The study explains how CYP119 hydroxylates lauric acid in a reaction supported by putidaredoxin and putidaredoxin reductase. This helps to engineer the mutagenesis of the complementarity of the protein-protein interface.

Subjects :: Mutagenesis -- Chemical properties
Hydroxylation -- Analysis
Electron transport -- Analysis
Chemistry

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