1. Clinical and Immunological Consequences of Early-life Thymectomy in Children with Congenital Heart Disease.
- Author
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Thiele, F., Stute, F., Boxnick, A., Bremer, S. J., Biermann, D., Pagel, J., Glau, L., Murko, S., Gehbauer, C., Krause, A., Olfe, J., Lütgehetmann, M., Gramer, G., Haag, F., Kozlik-Feldmann, R., Hübler, M., Sachweh, J. S., Tolosa, E., and Gieras, A.
- Subjects
THYMECTOMY ,CONGENITAL heart disease ,T-cell exhaustion ,LYMPHOPENIA ,IMMUNOLOGIC memory - Abstract
This article discusses the clinical and immunological consequences of early-life thymectomy in children with congenital heart disease (CHD). Thymectomy, the removal of the thymus, is often performed during cardiovascular surgery in these children. The study found that thymectomized children commonly exhibit lymphopenia and an altered T cell profile, including a decrease in naïve CD4 and CD8 cells and an increase in memory T cells. They also observed signs of premature immune aging, reduced thymic output, and potential risks of autoimmune development later in life. The findings highlight the importance of monitoring the long-term consequences of early-life thymectomy. [Extracted from the article]
- Published
- 2024
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