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Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors.
- Source :
-
Molecular genetics and metabolism reports [Mol Genet Metab Rep] 2023 May 04; Vol. 35, pp. 100977. Date of Electronic Publication: 2023 May 04 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- We report on liver transplantation in two patients with GSD Ib on treatment with empagliflozin. The use of this SGLT2 inhibitor resulted in a marked decrease of 1,5-anhydroglucitol which has an important role in the development of neutropenia in this condition. As intended, this caused a significant rise of neutrophil numbers. Liver transplantation alone did not produce the desired effect and our observation argues for continuing SGLT2 inhibitor treatment after transplantation.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2023 The Authors.)
Details
- Language :
- English
- ISSN :
- 2214-4269
- Volume :
- 35
- Database :
- MEDLINE
- Journal :
- Molecular genetics and metabolism reports
- Publication Type :
- Academic Journal
- Accession number :
- 37275680
- Full Text :
- https://doi.org/10.1016/j.ymgmr.2023.100977