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531 results on '"Muraca, M"'

2. First SOLPS‐ITER simulations of ASDEX Upgrade partially detached H‐mode with boron impurity: The missing radiation at the outer strike‐point region.

Author

Makarov, S. O., Coster, D. P., Gleiter, T., Brida, D., Muraca, M., Dux, R., David, P., Kurzan, B., Bonnin, X., and O'Mullane, M.

Subjects
THOMSON scattering, LANGMUIR probes, BORON, SOWING, RADIATION
Abstract

Partially detached H‐modes are the baseline regime for the future ITER operation. The ASDEX Upgrade partially detached H‐mode is modeled using the SOLPS‐ITER code with drifts enabled and compared with experimental data. For the first time, boron (B) impurity is simulated in the Scrape‐off layer (SOL) and divertor. A comparison between divertor diagnostics and discrepancies between Langmuir probe and Divertor Thomson scattering/Stark broadening diagnostic are discussed. In the modeling, experimental target profiles are reproduced if the experimental level of radiation in the SOL and divertor is achieved using nitrogen (N) impurity seeding. Bolometry measurements detect substantial radiation from the partially detached outer strike point. With B radiation, this maximum in bolometry data is reproduced in the modeling, which is not possible with N alone. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Imaging of extracellular vesicles derived from human bone marrow mesenchymal stem cells using fluorescent and magnetic labels

Author

Dabrowska S, Del Fattore A, Karnas E, Frontczak-Baniewicz M, Kozlowska H, Muraca M, Janowski M, and Lukomska B

Subjects
mesenchymal stem cells (MSCs), extracellular vesicles (EVs), cell tracking, fluorescent dye, iron oxide, MRI, Medicine (General), R5-920
Abstract

Sylwia Dabrowska,1 Andrea Del Fattore,2 Elzbieta Karnas,3,4 Malgorzata Frontczak-Baniewicz,5 Hanna Kozlowska,6 Maurizio Muraca,7 Miroslaw Janowski,1,8 Barbara Lukomska1 1NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland; 2Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; 3Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; 4Malopolska Centre of Biotechnology, Krakow, Poland; 5Electron Microscopy Platform, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland; 6Laboratory of Advanced Microscopy Techniques, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland; 7Department of Women’s and Children’s Health, University of Padua, Padua, Italy; 8Russel H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA Background: Mesenchymal stem cells have been shown therapeutic in various neurological disorders. Recent studies support the notion that the predominant mechanism by which MSCs act is through the release of extracellular vesicles (EVs). EVs seem to have similar therapeutic activity as their cellular counterparts and may represent an interesting alternative standalone therapy for various diseases. The aim of the study was to optimize the method of EV imaging to better understand therapeutic effects mediated by EVs.Methods: The fluorescent lipophilic stain PKH26 and superparamagnetic iron oxide nanoparticles conjugated with rhodamine (Molday ION Rhodamine B™) were used for the labeling of vesicles in human bone marrow MSCs (hBM-MSCs). The entire cycle from intracellular vesicles to EVs followed by their uptake by hBM-MSCs has been studied. The identity of vesicles has been proven by antibodies against: anti-CD9, -CD63, and -CD81 (tetraspanins). NanoSight particle tracking analysis (NTA), high-resolution flow cytometric analysis, transmission electron microscopy (TEM), ELYRA PS.1 super-resolution microscopy, and magnetic resonance imaging (MRI) were used for the characterization of vesicles.Results: The PKH26 and Molday ION were exclusively localized in intracellular vesicles positively stained for EV markers: CD9, CD63, and CD81. The isolated EVs represent heterogeneous population of various sizes as confirmed by NTA. The TEM and MRI were capable to show successful labeling of EVs using ION. Co-culture of EVs with hBM-MSCs revealed their uptake by cells in vitro, as visualized by the co-localization of PKH26 or Molday ION with tetraspanins inside hBM-MSCs.Conclusion: PKH26 and Molday ION seem to be biocompatible with EVs, and the labeling did not interfere with the capability of EVs to re-enter hBM-MSCs during co-culture in vitro. Magnetic properties of IONs provide an additional advantage for the imaging of EV using TEM and MRI. Keywords: mesenchymal stem cells, extracellular vesicles, cell tracking, fluorescent dye, iron oxide, MRI

Published
2018

4. Perceived barriers and facilitators to health behaviors in European childhood cancer survivors: A qualitative PanCareFollowUp study.

Author

Bouwman, E., Pluijm, S.M.F., Stollman, I.D., Araujo-Soares, V., Blijlevens, N.M.A., Follin, C., Winther, J.F., Hjorth, L., Kepak, T., Kepakova, K., Kremer, L.C.M., Muraca, M., Pal, H.J.H. van der, Schneider, C., Uyttebroeck, A., Vercruysse, G., Skinner, R., Brown, M.C., Hermens, R.P., Groot-Loonen, J.J., Bouwman, E., Pluijm, S.M.F., Stollman, I.D., Araujo-Soares, V., Blijlevens, N.M.A., Follin, C., Winther, J.F., Hjorth, L., Kepak, T., Kepakova, K., Kremer, L.C.M., Muraca, M., Pal, H.J.H. van der, Schneider, C., Uyttebroeck, A., Vercruysse, G., Skinner, R., Brown, M.C., Hermens, R.P., and Groot-Loonen, J.J.

Abstract

01 juni 2023, Contains fulltext : upload_in_progress_2066_294199.pdf (Publisher’s version ) (Closed access), BACKGROUND: Healthy behaviors, that is, engaging in regular physical activities, maintaining a healthy diet, limiting alcohol consumption, and avoiding tobacco and drug use, decrease the risk of developing late adverse health conditions in childhood cancer survivors. However, childhood cancer survivors may experience barriers to adopting and maintaining healthy behaviors. This study aimed to assess these barriers and facilitators to health behavior adoption and maintenance in childhood cancer survivors. METHODS: A focus group ( n = 12) and semi-structured telephone interviews ( n = 20) were conducted with a selected sample of European and Dutch childhood cancer survivors, respectively. The Theoretical Domains Framework (TDF) was used to inform the topic guide and analysis. Inductive thematic analysis was applied to identify categories relating to barriers and facilitators of health behavior adoption and maintenance, after which they were deductively mapped onto the TDF. RESULTS: Ten TDF domains were identified in the data of which "Knowledge," "Beliefs about consequences," "Environmental context and resources," and "Social influences" were most commonly reported. Childhood cancer survivors expressed a need for knowledge on the importance of healthy behaviors, possibly provided by healthcare professionals. They indicated physical and long-term benefits of healthy behaviors, available professional support, and a supporting and health-consciously minded work and social environment to be facilitators. Barriers were mostly related to a lack of available time and an unhealthy environment. Lastly, (social) media was perceived as both a barrier and a facilitator to healthy behaviors. CONCLUSION: This study has identified education and available professional support in health behaviors and the relevance of healthy behaviors for childhood cancer survivors as key opportunities for stimulating health behavior adoption in childhood cancer survivors. Incorporating health behavi

Published
2023

5. Healthcare professionals' perceived barriers and facilitators of health behavior support provision: A qualitative study.

Author

Bouwman, E., Pluijm, S.M.F., Stollman, I.D., Araujo-Soares, V., Blijlevens, N.M.A., Follin, C., Falck Winther, J., Hjorth, L., Kepak, T., Kepakova, K., Kremer, L.C.M., Muraca, M., Pal, H.J. van der, Schneider, C., Uyttebroeck, A., Vercruysse, G., Skinner, R., Brown, M.C., Hermens, R.P., Loonen, J.J., Bouwman, E., Pluijm, S.M.F., Stollman, I.D., Araujo-Soares, V., Blijlevens, N.M.A., Follin, C., Falck Winther, J., Hjorth, L., Kepak, T., Kepakova, K., Kremer, L.C.M., Muraca, M., Pal, H.J. van der, Schneider, C., Uyttebroeck, A., Vercruysse, G., Skinner, R., Brown, M.C., Hermens, R.P., and Loonen, J.J.

Abstract

Contains fulltext : 291775.pdf (Publisher’s version ) (Open Access), BACKGROUND: Childhood cancer survivors (CCSs) have an increased risk of developing chronic health conditions. Evidence suggests that poor health behaviors further increase health risks. Healthcare professionals (HCPs) involved in survivorship care have a key role in providing health behavior support (HBS) but can feel limited in their ability to do so. This study aims to explore European HCPs perceived facilitators and barriers to providing HBS to CCSs. METHODS: Five focus groups with 30 HCPs from survivorship care clinics across Europe were conducted. Topic guides were informed by the Theoretical Domains Framework (TDF) to capture domains that may influence provision of HBS. Focus groups were analyzed with thematic analysis. Transcripts were inductively coded, after which axial coding was applied to organize codes into categories. Finally, categories were mapped onto the TDF domains. RESULTS: Nine TDF domains were identified in the data. The most commonly reported TDF domains were "Knowledge", "Skills", and "Environmental context and resources". HCPs indicated that their lack of knowledge of the association between late effects and health behaviors, besides time restrictions, were barriers to HBS. Facilitators for HBS included possession of skills needed to pass on health behavior information, good clinic organization, and an established network of HCPs. CONCLUSIONS: This study identified education and training of HCPs as key opportunities to improve HBS. Survivorship care clinics should work towards establishing well-integrated structured care with internal and external networks including HBS being part of routine care. Proper understanding of facilitators and barriers should lead to better survivorship care for CCSs.

Published
2023

6. Current practices of follow-up programs for childhood cancer survivors in Italy

Author

Terenziani, M, Tozzi, A, Diaco, L, Biasin, E, Cattoni, A, Croci, I, Fraschini, D, Giorgiani, G, Haupt, R, Muraca, M, Pillon, M, Sironi, G, Valsecchi, M, Mastronuzzi, A, Terenziani, Monica, Tozzi, Alberto Eugenio, Diaco, Laura, Biasin, Eleonora, Cattoni, Alessandro, Croci, Ileana, Fraschini, Donatella, Giorgiani, Giovanna, Haupt, Riccardo, Muraca, Monica, Pillon, Marta, Sironi, Giovanna, Valsecchi, Maria Grazia, Mastronuzzi, Angela, Terenziani, M, Tozzi, A, Diaco, L, Biasin, E, Cattoni, A, Croci, I, Fraschini, D, Giorgiani, G, Haupt, R, Muraca, M, Pillon, M, Sironi, G, Valsecchi, M, Mastronuzzi, A, Terenziani, Monica, Tozzi, Alberto Eugenio, Diaco, Laura, Biasin, Eleonora, Cattoni, Alessandro, Croci, Ileana, Fraschini, Donatella, Giorgiani, Giovanna, Haupt, Riccardo, Muraca, Monica, Pillon, Marta, Sironi, Giovanna, Valsecchi, Maria Grazia, and Mastronuzzi, Angela

Abstract

Introduction: Quality of life in childhood cancer survivors is largely affected by survivorship care and transition from treatment to long-term follow-up (LTFU). Referring to evidence-based recommendations, we wanted to evaluate LTFU care for survivors through a survey among the Italian Association for Pediatric Hematology-Oncology (AIEOP) centers. The project aimed to evaluate the availability of services in Italy, investigate strengths and weaknesses, analyze improvements of awareness in the field, and identify the gaps that need to be addressed by different centers. Methods: Together with the family representatives, on behalf of AIEOP’s Late Effects Working Group, we developed a questionnaire on assisting childhood cancer survivors. All AIEOP centers received one questionnaire including information on local health system organizations; LTFU for childhood cancer survivors; services for adult survivors of childhood cancer; information provided to survivors/caregivers and care plan delivery. Results: Forty-eight AIEOP centers were contacted and 42 replied, with a response rate of 87.5%. The majority of respondents confirmed their interest in assisting patients with a survivorship care plan (95.2%), regardless of a clinic or dedicated staff. Discussion: This is the first overview of LTFU in Italy, which provides detailed results at national levels, prompting consideration of improvements in the last decade. Although there is a high level of interest in survivorship care, many centers lack resources to implement such programs. The identification of these challenges is useful for planning future strategies.

Published
2023

13. The PanCareFollowUp Care Intervention: A European harmonised approach to person-centred guideline-based survivorship care after childhood, adolescent and young adult cancer

Author

Kalsbeek, R.J. van, Mulder, R.L., Haupt, R., Muraca, M., Hjorth, L., Follin, C., Kepak, T., Kepakova, K., Uyttebroeck, A., Mangelschots, M., Winther, J. Falck, Loonen, J.J., Michel, G., Bardi, E., Frederiksen, L. Elmerdahl, Hartogh, J. den, Mader, L., Roser, K., Schneider, C., Brown, M.C., Brunhofer, M., Göttgens, I.L.E., Hermens, R.P.M.G., Kienesberger, A., Korevaar, J.C., Skinner, R., Pal, H.J. van der, Kremer, L.C., Kalsbeek, R.J. van, Mulder, R.L., Haupt, R., Muraca, M., Hjorth, L., Follin, C., Kepak, T., Kepakova, K., Uyttebroeck, A., Mangelschots, M., Winther, J. Falck, Loonen, J.J., Michel, G., Bardi, E., Frederiksen, L. Elmerdahl, Hartogh, J. den, Mader, L., Roser, K., Schneider, C., Brown, M.C., Brunhofer, M., Göttgens, I.L.E., Hermens, R.P.M.G., Kienesberger, A., Korevaar, J.C., Skinner, R., Pal, H.J. van der, and Kremer, L.C.

Abstract

Item does not contain fulltext, BACKGROUND: Long-term follow-up (LTFU) care, although endorsed, is not available for the majority of adult survivors of childhood, adolescence and young adult (CAYA) cancer. Barriers to implementation include lack of time, knowledge, personnel and funding. Sustainable solutions are urgently needed to address the needs of CAYA cancer survivors to improve the quality of life and reduce the burden of late effects on survivors, health care systems and society. The European Union-funded PanCareFollowUp project, initiated by the Pan-European Network for Care of Survivors after Childhood and Adolescent Cancer, was established to facilitate the implementation of person-centred survivorship care across Europe. PATIENTS AND METHODS: The PanCareFollowUp Care Intervention was co-developed with survivors as part of the PanCareFollowUp project. It is a person-centred approach to survivorship care, supported by guidelines and with flexibility to adapt to local health care settings. The Care Intervention consists of three steps: (1) previsit completion of a Survivor Questionnaire (by the survivor) and Treatment Summary (by the health care provider [HCP]), (2) a clinic visit including shared decision-making, and (3) a follow-up call to finalise the individualised Survivorship Care Plan. RESULTS: We developed the key components of the PanCareFollowUp Care Intervention: a PanCareFollowUp Survivor Questionnaire, Treatment Summary template, Survivorship Care Plan template, and educational materials for HCPs and survivors. Wide implementation of the PanCareFollowUp Care Intervention will be supported with a freely distributed Replication Manual on completion of the PanCareFollowUp project. CONCLUSIONS: The PanCareFollowUp Care Intervention will support the implementation of person-centred, guideline-based LTFU care in different health care settings across Europe to improve survivors' health and well-being.

Published
2022

14. Evaluating the feasibility, effectiveness and costs of implementing person-centred follow-up care for childhood cancer survivors in four European countries: the PanCareFollowUp Care prospective cohort study protocol

Author

Kalsbeek, R.J. van, Korevaar, J.C., Rijken, M., Haupt, R., Muraca, M., Kepák, T., Kepakova, K., Blondeel, A., Boes, S., Frederiksen, L.E., Essiaf, S., Winther, J.F., Hermens, R.P.M.G., Kienesberger, A., Loonen, J.J., Michel, G., Mulder, R.L., O'Brien, K.B., Pal, H.J. van der, Pluijm, S.M.F., Roser, K., Skinner, R., Renard, M., Uyttebroeck, A., Follin, C., Hjorth, L., Kremer, L.C.M., Kalsbeek, R.J. van, Korevaar, J.C., Rijken, M., Haupt, R., Muraca, M., Kepák, T., Kepakova, K., Blondeel, A., Boes, S., Frederiksen, L.E., Essiaf, S., Winther, J.F., Hermens, R.P.M.G., Kienesberger, A., Loonen, J.J., Michel, G., Mulder, R.L., O'Brien, K.B., Pal, H.J. van der, Pluijm, S.M.F., Roser, K., Skinner, R., Renard, M., Uyttebroeck, A., Follin, C., Hjorth, L., and Kremer, L.C.M.

Abstract

Item does not contain fulltext, INTRODUCTION: Long-term survival after childhood cancer often comes at the expense of late, adverse health conditions. However, survivorship care is frequently not available for adult survivors in Europe. The PanCareFollowUp Consortium therefore developed the PanCareFollowUp Care Intervention, an innovative person-centred survivorship care model based on experiences in the Netherlands. This paper describes the protocol of the prospective cohort study (Care Study) to evaluate the feasibility and the health economic, clinical and patient-reported outcomes of implementing PanCareFollowUp Care as usual care in four European countries. METHODS AND ANALYSIS: In this prospective, longitudinal cohort study with at least 6 months of follow-up, 800 childhood cancer survivors will receive the PanCareFollowUp Care Intervention across four study sites in Belgium, Czech Republic, Italy and Sweden, representing different healthcare systems. The PanCareFollowUp Care Intervention will be evaluated according to the Reach, Effectiveness, Adoption, Implementation and Maintenance framework. Clinical and research data are collected through questionnaires, a clinic visit for multiple medical assessments and a follow-up call. The primary outcome is empowerment, assessed with the Health Education Impact Questionnaire. A central data centre will perform quality checks, data cleaning and data validation, and provide support in data analysis. Multilevel models will be used for repeated outcome measures, with subgroup analysis, for example, by study site, attained age, sex or diagnosis. ETHICS AND DISSEMINATION: This study will be conducted in accordance with the guidelines of Good Clinical Practice and the Declaration of Helsinki. The study protocol has been reviewed and approved by all relevant ethics committees. The evidence and insights gained by this study will be summarised in a Replication Manual, also including the tools required to implement the PanCareFollowUp Care Intervention in oth

Published
2022

15. Progress from ASDEX Upgrade experiments in preparing the physics basis of ITER operation and DEMO scenario development

Author

Stroth, U., primary, Aguiam, D., additional, Alessi, E., additional, Angioni, C., additional, Arden, N., additional, Parra, R. Arredondo, additional, Artigues, V., additional, Asunta, O., additional, Balden, M., additional, Bandaru, V., additional, Banon-Navarro, A., additional, Behler, K., additional, Bergmann, A., additional, Bergmann, M., additional, Bernardo, J., additional, Bernert, M., additional, Biancalani, A., additional, Bielajew, R., additional, Bilato, R., additional, Birkenmeier, G., additional, Blanken, T., additional, Bobkov, V., additional, Bock, A., additional, Body, T., additional, Bolzonella, T., additional, Bonanomi, N., additional, Bortolon, A., additional, Böswirth, B., additional, Bottereau, C., additional, Bottino, A., additional, van den Brand, H., additional, Brenzke, M., additional, Brezinsek, S., additional, Brida, D., additional, Brochard, F., additional, Bruhn, C., additional, Buchanan, J., additional, Buhler, A., additional, Burckhart, A., additional, Camenen, Y., additional, Cannas, B., additional, Megias, P. Cano, additional, Carlton, D., additional, Carr, M., additional, Carvalho, P., additional, Castaldo, C., additional, Cavedon, M., additional, Cazzaniga, C., additional, Challis, C., additional, Chankin, A., additional, Cianfarani, C., additional, Clairet, F., additional, Coda, S., additional, Coelho, R., additional, Coenen, J.W., additional, Colas, L., additional, Conway, G., additional, Costea, S., additional, Coster, D., additional, Cote, T., additional, Creely, A.J., additional, Croci, G., additional, Zabala, D.J. Cruz, additional, Cseh, G., additional, Czarnecka, A., additional, Cziegler, I., additional, D’Arcangelo, O., additional, Molin, A. Dal, additional, David, P., additional, Day, C., additional, de Baar, M., additional, de Marné, P., additional, Delogu, R., additional, Denk, S., additional, Denner, P., additional, Di Siena, A., additional, Palacios Durán, J.J. Dominguez, additional, Dunai, D., additional, Drenik, A., additional, Dreval, M., additional, Drube, R., additional, Dunne, M., additional, Duval, B.P., additional, Dux, R., additional, Eich, T., additional, Elgeti, S., additional, Encheva, A., additional, Engelhardt, K., additional, Erdös, B., additional, Erofeev, I., additional, Esposito, B., additional, Fable, E., additional, Faitsch, M., additional, Fantz, U., additional, Farnik, M., additional, Faugel, H., additional, Felici, F., additional, Ficker, O., additional, Fietz, S., additional, Figueredo, A., additional, Fischer, R., additional, Ford, O., additional, Frassinetti, L., additional, Fröschle, M., additional, Fuchert, G., additional, Fuchs, J.C., additional, Fünfgelder, H., additional, Futatani, S., additional, Galazka, K., additional, Galdon-Quiroga, J., additional, Escolà, D. Gallart, additional, Gallo, A., additional, Gao, Y., additional, Garavaglia, S., additional, Muñoz, M. Garcia, additional, Geiger, B., additional, Giannone, L., additional, Gibson, S., additional, Gil, L., additional, Giovannozzi, E., additional, Glöggler, S., additional, Gobbin, M., additional, Martin, J. Gonzalez, additional, Goodman, T., additional, Gorini, G., additional, Görler, T., additional, Gradic, D., additional, Granucci, G., additional, Gräter, A., additional, Greuner, H., additional, Griener, M., additional, Groth, M., additional, Gude, A., additional, Guimarais, L., additional, Günter, S., additional, Haas, G., additional, Hakola, A.H., additional, Ham, C., additional, Happel, T., additional, den Harder, N., additional, Harrer, G., additional, Harrison, J., additional, Hauer, V., additional, Hayward-Schneider, T., additional, Heinemann, B., additional, Hellsten, T., additional, Henderson, S., additional, Hennequin, P., additional, Herrmann, A., additional, Heyn, E., additional, Hitzler, F., additional, Hobirk, J., additional, Höfler, K., additional, Holm, J.H., additional, Hölzl, M., additional, Hopf, C., additional, Horvath, L., additional, Höschen, T., additional, Houben, A., additional, Hubbard, A., additional, Huber, A., additional, Hunger, K., additional, Igochine, V., additional, Iliasova, M., additional, Ilkei, T., additional, Björk, K. Insulander, additional, Ionita-Schrittwieser, C., additional, Ivanova-Stanik, I., additional, Jacob, W., additional, Jaksic, N., additional, Janky, F., additional, Jansen van Vuuren, A., additional, Jardin, A., additional, Jaulmes, F., additional, Jenko, F., additional, Jensen, T., additional, Joffrin, E., additional, Kallenbach, A., additional, Kálvin, S., additional, Kantor, M., additional, Kappatou, A., additional, Kardaun, O., additional, Karhunen, J., additional, Käsemann, C.-P., additional, Kasilov, S., additional, Kendl, A., additional, Kernbichler, W., additional, Khilkevitch, E., additional, Kirk, A., additional, Hansen, S. Kjer, additional, Klevarova, V., additional, Kocsis, G., additional, Koleva, M., additional, Komm, M., additional, Kong, M., additional, Krämer-Flecken, A., additional, Krieger, K., additional, Krivska, A., additional, Kudlacek, O., additional, Kurki-Suonio, T., additional, Kurzan, B., additional, Labit, B., additional, Lackner, K., additional, Laggner, F., additional, Lahtinen, A., additional, Lang, P.T., additional, Lauber, P., additional, Leuthold, N., additional, Li, L., additional, Likonen, J., additional, Linder, O., additional, Lipschultz, B., additional, Liu, Y., additional, Lohs, A., additional, Lu, Z., additional, Luda di Cortemiglia, T., additional, Luhmann, N.C., additional, Lunt, T., additional, Lyssoivan, A., additional, Maceina, T., additional, Madsen, J., additional, Magnanimo, A., additional, Maier, H., additional, Mailloux, J., additional, Maingi, R., additional, Maj, O., additional, Maljaars, E., additional, Manas, P., additional, Mancini, A., additional, Manhard, A., additional, Mantica, P., additional, Mantsinen, M., additional, Manz, P., additional, Maraschek, M., additional, Marchetto, C., additional, Marrelli, L., additional, Martin, P., additional, Martitsch, A., additional, Matos, F., additional, Mayer, M., additional, Mayoral, M.-L., additional, Mazon, D., additional, McCarthy, P.J., additional, McDermott, R., additional, Merkel, R., additional, Merle, A., additional, Meshcheriakov, D., additional, Meyer, H., additional, Milanesio, D., additional, Cabrera, P. Molina, additional, Monaco, F., additional, Muraca, M., additional, Nabais, F., additional, Naulin, V., additional, Nazikian, R., additional, Nem, R.D., additional, Nemes-Czopf, A., additional, Neu, G., additional, Neu, R., additional, Nielsen, A.H., additional, Nielsen, S.K., additional, Nishizawa, T., additional, Nocente, M., additional, Noterdaeme, J.-M., additional, Novikau, I., additional, Nowak, S., additional, Oberkofler, M., additional, Ochoukov, R., additional, Olsen, J., additional, Orain, F., additional, Palermo, F., additional, Pan, O., additional, Papp, G., additional, Perez, I. Paradela, additional, Pau, A., additional, Pautasso, G., additional, Paz-Soldan, C., additional, Petersson, P., additional, Piovesan, P., additional, Piron, C., additional, Plank, U., additional, Plaum, B., additional, Plöck, B., additional, Plyusnin, V., additional, Pokol, G., additional, Poli, E., additional, Porte, L., additional, Pütterich, T., additional, Ramisch, M., additional, Rasmussen, J., additional, Ratta, G., additional, Ratynskaia, S., additional, Raupp, G., additional, Réfy, D., additional, Reich, M., additional, Reimold, F., additional, Reiser, D., additional, Reisner, M., additional, Reiter, D., additional, Ribeiro, T., additional, Riedl, R., additional, Riesch, J., additional, Rittich, D., additional, Rodriguez, J.F. Rivero, additional, Rocchi, G., additional, Rodriguez-Fernandez, P., additional, Rodriguez-Ramos, M., additional, Rohde, V., additional, Ronchi, G., additional, Ross, A., additional, Rott, M., additional, Rubel, M., additional, Ryan, D.A., additional, Ryter, F., additional, Saarelma, S., additional, Salewski, M., additional, Salmi, A., additional, Samoylov, O., additional, Sanchez, L. Sanchis, additional, Santos, J., additional, Sauter, O., additional, Schall, G., additional, Schlüter, K., additional, Schmid, K., additional, Schmitz, O., additional, Schneider, P.A., additional, Schrittwieser, R., additional, Schubert, M., additional, Schuster, C., additional, Schwarz-Selinger, T., additional, Schweinzer, J., additional, Seliunin, E., additional, Shabbir, A., additional, Shalpegin, A., additional, Sharapov, S., additional, Sheikh, U., additional, Shevelev, A., additional, Sias, G., additional, Siccinio, M., additional, Sieglin, B., additional, Sigalov, A., additional, Silva, A., additional, Silva, C., additional, Silvagni, D., additional, Simpson, J., additional, Sipilä, S., additional, Smigelskis, E., additional, Snicker, A., additional, Solano, E., additional, Sommariva, C., additional, Sozzi, C., additional, Spizzo, G., additional, Spolaore, M., additional, Stegmeir, A., additional, Stejner, M., additional, Stober, J., additional, Strumberge, E., additional, Lopez, G. Suarez, additional, Sun, H.-J., additional, Suttrop, W., additional, Sytova, E., additional, Szepesi, T., additional, Tál, B., additional, Tala, T., additional, Tardini, G., additional, Tardocchi, M., additional, Terranova, D., additional, Teschke, M., additional, Thorén, E., additional, Tierens, W., additional, Told, D., additional, Treutterer, W., additional, Trevisan, G., additional, Trier, E., additional, Tripský, M., additional, Usoltceva, M., additional, Valisa, M., additional, Valovic, M., additional, van Zeeland, M., additional, Vannini, F., additional, Vanovac, B., additional, Varela, P., additional, Varoutis, S., additional, Vianello, N., additional, Vicente, J., additional, Verdoolaege, G., additional, Vierle, T., additional, Viezzer, E., additional, Voitsekhovitch, I., additional, von Toussaint, U., additional, Wagner, D., additional, Wang, X., additional, Weiland, M., additional, White, A.E., additional, Willensdorfer, M., additional, Wiringer, B., additional, Wischmeier, M., additional, Wolf, R., additional, Wolfrum, E., additional, Yang, Q., additional, Yu, Q., additional, Zagórski, R., additional, Zammuto, I., additional, Zehetbauer, T., additional, Zhang, W., additional, Zholobenko, W., additional, Zilker, M., additional, Zito, A., additional, Zohm, H., additional, Zoletnik, S., additional, and EUROfusion MST1 Team, the, additional

Published
2022
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16. Reduced Transport Models for a Tokamak Flight Simulator

Author

Muraca, M., Fable, E., https://orcid.org/0000-0001-5019-9685, Angioni, C., David, P., https://orcid.org/0000-0003-4837-8507, Luda, T., https://orcid.org/0000-0002-9941-0039, Zohm, H., https://orcid.org/0000-0002-8870-7806, and ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society

Published
2022

17. The modeling of a tokamak plasma discharge, from first principles to a flight simulator

Author

Fable, E., Janky, F., Treutterer, W., Englberger, M., Schramm, R., Muraca, M., Angioni, C., Kudlacek, O., Poli, E., Reich, M., Siccinio, M., Tardini, G., Weiland, M., Wu, C., Zohm, H., and ASDEX Upgrade Team

Subjects
Technology, ddc:600
Abstract

A newly developed tool to simulate a tokamak full discharge is presented. The tokamak 'flight simulator' Fenix couples the tokamak control system with a fast and reduced plasma model, which is realistic enough to take into account several of the plasma non-linearities. A distinguishing feature of this modeling tool is that it only requires the pulse schedule (PS) as input to the simulator. The output is a virtual realization of the full discharge, whose time traces can then be used to judge if the PS satisfies control/physics goals or needs to be revised. This tool is envisioned for routine use in the control room before each pulse is performed, but can also be used off-line to correct PS in advance, or to develop and validate reduced models, control schemes for future machines like a commercial reactor, simulating realistic actuators and sensors behavior.

Published
2022
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21. Effect of Genetic Variation in CYP450 on Gonadal Impairment in a European Cohort of Female Childhood Cancer Survivors, Based on a Candidate Gene Approach: Results from the PanCareLIFE Study

Author

Perk, M.E.M. van der, Broer, L., Yasui, Y., Robison, L.L., Hudson, M.M., Laven, J. S. E., Pal, H.J. van der, Tissing, W.J., Versluys, B., Bresters, D., Kaspers, G.J., Vries, A.C.M. de, Lambalk, C.B., Overbeek, A., Loonen, J.J., Beerendonk, C.C.M., Byrne, J., Berger, C., Clemens, E., Dirksen, U., Winther, J. Falck, Fosså, S.D., Grabow, D., Muraca, M., Kaiser, M., Kepák, T., Kruseova, J., Modan-Moses, D., Spix, C., Zolk, O., Kaatsch, P., Krijthe, J.H., Kremer, L.C., Brooke, R.J., Baedke, J.L., Schaik, R.H. van, Anker, J.N. van den, Uitterlinden, A.G., Bos, A.M., Leeuwen, F.E. van, Dulmen-den Broeder, E. van, Kooi, A.L. Van der, Heuvel-Eibrink, M.M. van den, PanCare, L.C. On Behalf Of Th, Perk, M.E.M. van der, Broer, L., Yasui, Y., Robison, L.L., Hudson, M.M., Laven, J. S. E., Pal, H.J. van der, Tissing, W.J., Versluys, B., Bresters, D., Kaspers, G.J., Vries, A.C.M. de, Lambalk, C.B., Overbeek, A., Loonen, J.J., Beerendonk, C.C.M., Byrne, J., Berger, C., Clemens, E., Dirksen, U., Winther, J. Falck, Fosså, S.D., Grabow, D., Muraca, M., Kaiser, M., Kepák, T., Kruseova, J., Modan-Moses, D., Spix, C., Zolk, O., Kaatsch, P., Krijthe, J.H., Kremer, L.C., Brooke, R.J., Baedke, J.L., Schaik, R.H. van, Anker, J.N. van den, Uitterlinden, A.G., Bos, A.M., Leeuwen, F.E. van, Dulmen-den Broeder, E. van, Kooi, A.L. Van der, Heuvel-Eibrink, M.M. van den, and PanCare, L.C. On Behalf Of Th

Abstract

Contains fulltext : 237733.pdf (Publisher’s version ) (Open Access), BACKGROUND: Female childhood cancer survivors (CCSs) carry a risk of therapy-related gonadal dysfunction. Alkylating agents (AA) are well-established risk factors, yet inter-individual variability in ovarian function is observed. Polymorphisms in CYP450 enzymes may explain this variability in AA-induced ovarian damage. We aimed to evaluate associations between previously identified genetic polymorphisms in CYP450 enzymes and AA-related ovarian function among adult CCSs. METHODS: Anti-Müllerian hormone (AMH) levels served as a proxy for ovarian function in a discovery cohort of adult female CCSs, from the pan-European PanCareLIFE cohort (n = 743; age (years): median 25.8, interquartile range (IQR) 22.1-30.6). Using two additive genetic models in linear and logistic regression, nine genetic variants in three CYP450 enzymes were analyzed in relation to cyclophosphamide equivalent dose (CED) score and their impact on AMH levels. The main model evaluated the effect of the variant on AMH and the interaction model evaluated the modifying effect of the variant on the impact of CED score on log-transformed AMH levels. Results were validated, and meta-analysis performed, using the USA-based St. Jude Lifetime Cohort (n = 391; age (years): median 31.3, IQR 26.6-37.4). RESULTS: CYP3A4*3 was significantly associated with AMH levels in the discovery and replication cohort. Meta-analysis revealed a significant main deleterious effect (Beta (95% CI): -0.706 (-1.11--0.298), p-value = 7 × 10(-4)) of CYP3A4*3 (rs4986910) on log-transformed AMH levels. CYP2B6*2 (rs8192709) showed a significant protective interaction effect (Beta (95% CI): 0.527 (0.126-0.928), p-value = 0.01) on log-transformed AMH levels in CCSs receiving more than 8000 mg/m(2) CED. CONCLUSIONS: Female CCSs CYP3A4*3 carriers had significantly lower AMH levels, and CYP2B6*2 may have a protective effect on AMH levels. Identification of risk-contributing variants may improve individualized counselling regarding the treatme

Published
2021

22. Liver repopulation with bone marrow derived cells improves the metabolic disorder in the Gunn rat

Author

Muraca, M., Ferraresso, C., Vilei, M.T., Granato, A., Quarta, M., Cozzi, E., Rugge, M., Pauwelyn, K.A., Caruso, M., Avital, I., Inderbitzin, D., Demetriou, A.A., Forbes, S.J., and Realdi, G.

Subjects
Hyperbilirubinemia -- Care and treatment, B cells -- Physiological aspects, Rats as laboratory animals -- Physiological aspects, Rats as laboratory animals -- Research, Bone marrow -- Transplantation, Bone marrow -- Patient outcomes, Bone marrow -- Research, Health
Published
2007

26. Extracellular vesicles in combination with a biological scaffold allow the regain of muscle function after volumetric muscle loss

Author

Magarotto, F., primary, Hochuli, A., additional, Sgrô, A., additional, Andreetta, M., additional, Grassi, M., additional, Saggioro, M., additional, Nogara, L., additional, Tolomeo, A., additional, Francescato, R., additional, Collino, F., additional, Germano, G., additional, Caicci, F., additional, Maghin, E., additional, Piccoli, M., additional, Blaauw, B., additional, Gamba, P., additional, Muraca, M., additional, and Pozzobon, M., additional

Published
2021
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28. Bilirubin inhibits bile acid induced apoptosis in rat hepatocytes

Author

Granato, A., Gores, G., Vilei, M.T., Tolando, R., Ferraresso, C., and Muraca, M.

Subjects
Care and treatment, Prevention, Analysis, Physiological aspects, Genetic aspects, Research, Methods, Health aspects, Causes of, Apoptosis -- Physiological aspects -- Genetic aspects -- Health aspects -- Analysis -- Methods -- Research, Research methods -- Analysis -- Methods -- Physiological aspects -- Research -- Health aspects, Intestinal diseases -- Research -- Causes of -- Health aspects -- Care and treatment -- Genetic aspects -- Prevention, Liver diseases -- Health aspects -- Causes of -- Prevention -- Care and treatment -- Genetic aspects -- Research, Medical research -- Methods -- Analysis -- Physiological aspects -- Health aspects, Bile -- Physiological aspects -- Analysis -- Health aspects -- Research -- Methods, Patients -- Health aspects -- Care and treatment -- Physiological aspects -- Research -- Methods -- Analysis, Antioxidants (Nutrients) -- Physiological aspects -- Health aspects -- Research, Cholestasis -- Health aspects -- Causes of -- Prevention -- Research -- Care and treatment -- Genetic aspects, Hepatocytes -- Physiological aspects -- Genetic aspects -- Methods -- Health aspects -- Research -- Analysis, Bilirubin -- Physiological aspects -- Analysis -- Genetic aspects -- Methods -- Research -- Health aspects, Colorectal diseases -- Research -- Causes of -- Health aspects -- Care and treatment -- Genetic aspects -- Prevention, Antioxidants -- Physiological aspects -- Health aspects -- Research, Jaundice, Obstructive -- Health aspects -- Causes of -- Prevention -- Research -- Care and treatment -- Genetic aspects, Methodology -- Analysis -- Methods -- Physiological aspects -- Research -- Health aspects, Gastrointestinal diseases -- Research -- Causes of -- Health aspects -- Care and treatment -- Genetic aspects -- Prevention, Medicine, Experimental -- Methods -- Analysis -- Physiological aspects -- Health aspects, Liver cells -- Physiological aspects -- Genetic aspects -- Methods -- Health aspects -- Research -- Analysis
Abstract

Gut 2003;52:1774-1778 Background and aims: Hydrophobic bile acids contribute to hepatocellular injury in cholestasis and rapidly induce apoptosis in vitro; however, unlike Fas agonists, cholestasis does not cause extensive hepatocyte [...]

Published
2003

35. Guidance regarding COVID-19 for survivors of childhood, adolescent, and young adult cancer: A statement from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Verbruggen, LC, Wang, Y, Armenian, SH, Ehrhardt, MJ, van der Pal, HJH, van Dalen, EC, van As, JW, Bardi, E, Baust, K, Berger, C, Castagnola, E, Devine, KA, Gebauer, J, Marchak, JG, Glaser, AW, Groll, AH, Haeusler, GM, den Hartogh, J, Haupt, R, Hjorth, L, Kato, M, Kepak, T, Koopman, MMWR, Langer, T, Maeda, M, Michel, G, Muraca, M, Nathan, PC, van den Oever, SR, Pavasovic, V, Sato, S, Schulte, F, Sung, L, Tissing, W, Uyttebroeck, A, Mulder, RL, Kuehni, C, Skinner, R, Hudson, MM, Kremer, LCM, Verbruggen, LC, Wang, Y, Armenian, SH, Ehrhardt, MJ, van der Pal, HJH, van Dalen, EC, van As, JW, Bardi, E, Baust, K, Berger, C, Castagnola, E, Devine, KA, Gebauer, J, Marchak, JG, Glaser, AW, Groll, AH, Haeusler, GM, den Hartogh, J, Haupt, R, Hjorth, L, Kato, M, Kepak, T, Koopman, MMWR, Langer, T, Maeda, M, Michel, G, Muraca, M, Nathan, PC, van den Oever, SR, Pavasovic, V, Sato, S, Schulte, F, Sung, L, Tissing, W, Uyttebroeck, A, Mulder, RL, Kuehni, C, Skinner, R, Hudson, MM, and Kremer, LCM

Abstract

Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) to summarize existing evidence and worldwide recommendations regarding evidence about factors/conditions associated with risk for a severe course of COVID-19 in CAYA cancer survivors, and to develop a consensus statement to provide guidance for healthcare practitioners and CAYA cancer survivors regarding COVID-19.

Published
2020

36. Administration of human msc?derived extracellular vesicles for the treatment of primary sclerosing cholangitis: Preclinical data in mdr2 knockout mice

Author

Angioni, R, Calì, B, Vigneswara, V, Crescenzi, M, Merino Rodriguez, Ana, Sánchez?rodríguez, R, Liboni, C, Hoogduijn, Martin, Newsome, PN, Muraca, M, Russo, FP, Viola, A, Angioni, R, Calì, B, Vigneswara, V, Crescenzi, M, Merino Rodriguez, Ana, Sánchez?rodríguez, R, Liboni, C, Hoogduijn, Martin, Newsome, PN, Muraca, M, Russo, FP, and Viola, A

Published
2020

43. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Author

Thery, C., Witwer, K. (Kenneth), Aikawa, E. (Elena), Alcaraz, M.J. (Maria Jose), Anderson, J.D. (Johnathon D), Andriantsitohaina, R. (Ramaroson), Antoniou, A. (Anna), Arab, T. (Tanina), Archer, F. (Fabienne), Atkin-Smith, G.K. (Georgia K), Ayre, D.C. (D Craig), Bach, J.-M. (Jean-Marie), Bachurski, D. (Daniel), Baharvand, H. (Hossein), Balaj, L. (Leonora), Baldacchino, S. (Shawn), Bauer, N.N. (Natalie N), Baxter, A.A. (Amy A), Bebawy, M. (Mary), Beckham, C. (Carla), Bedina Zavec, A. (Apolonija), Benmoussa, A. (Abderrahim), Berardi, A.C. (Anna C), Bergese, P. (Paolo), Bielska, E. (Ewa), Blenkiron, C. (Cherie), Bobis-Wozowicz, S. (Sylwia), Boilard, E. (Eric), Boireau, W. (Wilfrid), Bongiovanni, A. (Antonella), Borràs, F.E. (Francesc), Bosch, S. (Steffi), Boulanger, C.M. (Chantal), Breakefield, X. (Xandra), Breglio, A.M. (Andrew M), Brennan, M.Á. (Meadhbh Á), Brigstock, D.R. (David R), Brisson, A. (Alain), Broekman, M.L.D. (Marike), Bromberg, J.F. (Jacqueline F), Bryl-Górecka, P. (Paulina), Buch, S. (Shilpa), Buck, A.H. (Amy H), Burger, D. (Dylan), Busatto, S. (Sara), Buschmann, D. (Dominik), Bussolati, B. (Benedetta), Buzas, E. (Edit), Byrd, J.B. (James Bryan), Camussi, G. (Giovanni), Carter, D.R.F. (David RF), Caruso, S. (Sarah), Chamley, L.W. (Lawrence W), Chang, Y.-T. (Yu-Ting), Chaudhuri, A.D. (Amrita Datta), Chen, C. (Chihchen), Chen, S. (Shuai), Cheng, L. (Lesley), Chin, A.R. (Andrew R), Clayton, A. (Aled), Clerici, S.P. (Stefano P), Cocks, A. (Alex), Cocucci, E. (Emanuele), Coffey, R.J. (Robert J), Cordeiro-da-Silva, A. (Anabela), Couch, Y. (Yvonne), Coumans, F.A.W. (Frank AW), Coyle, B. (Beth), Crescitelli, R. (Rossella), Criado, M.F. (Miria Ferreira), D’Souza-Schorey, C. (Crislyn), Das, S. (Saumya), de Candia, P. (Paola), De Santana, E.F. (Eliezer F), De Wever, O. (Olivier), Del Portillo, H. (Hernando), Demaret, T. (Tanguy), Deville, S. (Sarah), Devitt, A. (Andrew), Dhondt, B. (Bert), Di Vizio, D. (Dolores), Dieterich, L.C. (Lothar C), Dolo, V. (Vincenza), Dominguez Rubio, A.P. (Ana Paula), Dominici, M. (Massimo), Dourado, M.R. (Mauricio R), Driedonks, T.A.P. (Tom AP), Duarte, F.V. (Filipe V), Duncan, H.M. (Heather M), Eichenberger, R.M. (Ramon M), Ekström, K. (Karin), EL Andaloussi, S. (Samir), Elie-Caille, C. (Celine), Erdbrügger, U. (Uta), Falcon-Perez, J.M. (Juan), Fatima, F. (Farah), Fish, J.E. (Jason E), Flores-Bellver, M. (Miguel), Försönits, A. (András), Frelet-Barrand, A. (Annie), Fricke, F. (Fabia), Fuhrmann, G. (Gregor), Gabrielsson, S. (Susanne), Gámez-Valero, A. (Ana), Gardiner, C. (Chris), Gärtner, K. (Kathrin), Gaudin, R. (Raphael), Gho, Y.S. (Yong Song), Giebel, B. (B.), Gilbert, C. (Caroline), Gimona, M. (Mario), Giusti, I. (Ilaria), Goberdhan, D.C.I. (Deborah CI), Görgens, A. (André), Gorski, S.M. (Sharon M), Greening, D.W. (David W.), Gross, J.C. (Julia Christina), Gualerzi, A. (Alice), Gupta, G.N. (Gopal N), Gustafson, D. (Dakota), Handberg, A. (Aase), Haraszti, R.A. (Reka A), Harrison, P. (Paul), Hegyesi, H. (Hargita), Hendrix, A. (An), Hill, A.F. (Andrew F), Hochberg, F.H. (Fred H), Hoffmann, K.F. (Karl F), Holder, B. (Beth), Holthofer, H. (Harry), Hosseinkhani, B. (Baharak), Hu, G. (Guoku), Huang, Y. (Yiyao), Huber, V. (Veronica), Hunt, S. (Stuart), Ibrahim, A.G.-E. (Ahmed Gamal-Eldin), Ikezu, T. (Tsuneya), Inal, J.M. (Jameel), Isin, M. (Mustafa), Ivanova, A. (Alena), Jackson, H.K. (Hannah K), Jacobsen, S. (Soren), Jay, S.M. (Steven M), Jayachandran, M. (Muthuvel), Jenster, G.W. (Guido), Jiang, L. (Lanzhou), Johnson, S.M. (Suzanne M), Jones, J.C. (Jennifer C), Jong, A. (Ambrose), Jovanovic-Talisman, T. (Tijana), Jung, S. (Stephanie), Kalluri, R. (Raghu), Kano, S.-I. (Shin-ichi), Kaur, S. (Sukhbir), Kawamura, Y. (Yumi), Keller, E.T. (Evan T), Khamari, D. (Delaram), Khomyakova, E. (Elena), Khvorova, A. (Anastasia), Kierulf, P. (Peter), Kim, K.P. (Kwang Pyo), Kislinger, T. (Thomas), Klingeborn, M. (Mikael), Klinke, D.J. (David J), Kornek, M. (Miroslaw), Kosanović, M.M. (Maja M), Kovács, Á.F. (Árpád Ferenc), Krämer-Albers, E.-M. (Eva-Maria), Krasemann, S. (Susanne), Krause, M. (Mirja), Kurochkin, I.V. (Igor V), Kusuma, G.D. (Gina D), Kuypers, S. (Sören), Laitinen, S. (Saara), Langevin, S.M. (Scott M), Languino, L.R. (Lucia R), Lannigan, J. (Joanne), Lässer, C. (Cecilia), Laurent, L.C. (Louise C), Lavieu, G. (Gregory), Lázaro-Ibáñez, E. (Elisa), Le Lay, S. (Soazig), Lee, M.-S. (Myung-Shin), Lee, Y.X.F. (Yi Xin Fiona), Lemos, D.S. (Debora S), Lenassi, M. (Metka), Leszczynska, A. (Aleksandra), Li, I.T.S. (Isaac TS), Liao, K. (Ke), Libregts, S.F. (Sten), Ligeti, E. (Erzsebet), Lim, R. (Rebecca), Lim, S.K. (Sai Kiang), Linē, A. (Aija), Linnemannstöns, K. (Karen), Llorente, A. (Alicia), Lombard, C.A. (Catherine A), Lorenowicz, M.J. (Magdalena J), Lörincz, Á.M. (Ákos M), Lötvall, J. (Jan), Lovett, J. (Jason), Lowry, M.C. (Michelle C), Loyer, X. (Xavier), Lu, Q. (Quan), Lukomska, B. (Barbara), Lunavat, T.R. (Taral R), Maas, S.L.N. (Sybren), Malhi, H. (Harmeet), Marcilla, A. (Antonio), Mariani, J. (Jacopo), Mariscal, J. (Javier), Martens-Uzunova, E.S. (Elena), Martin-Jaular, L. (Lorena), Martinez, M.C. (M Carmen), Martins, V.R. (Vilma Regina), Mathieu, M. (Mathilde), Mathivanan, S. (Suresh), Maugeri, M. (Marco), McGinnis, L.K. (Lynda K), McVey, M.J. (Mark J), Meckes, D.G. (David G), Meehan, K.L. (Katie L), Mertens, I. (Inge), Minciacchi, V.R. (Valentina R), Möller, A. (Andreas), Møller Jørgensen, M. (Malene), Morales-Kastresana, A. (Aizea), Morhayim, J. (Jess), Mullier, F. (Francois), Muraca, M. (Maurizio), Musante, L. (Luca), Mussack, V. (Veronika), Muth, D.C. (Dillon C), Myburgh, K.H. (Kathryn H), Najrana, T. (Tanbir), Nawaz, M. (Muhammad), Nazarenko, I. (Irina), Nejsum, P. (Peter), Neri, C. (Christian), Neri, T. (Tommaso), Nieuwland, C.C.M. (Carolien) van, Nimrichter, L. (Leonardo), Nolan, J.P. (John P), Nolte-’t Hoen, E.N.M. (Esther NM), Hooten, N.N. (Nicole Noren), O’Driscoll, L. (Lorraine), O’Grady, T. (Tina), O’Loghlen, A. (Ana), Ochiya, T. (Takahiro), Olivier, M. (Martin), Ortiz, A. (Alberto), Ortiz, L.A. (Luis A), Osteikoetxea, X. (Xabier), Ostegaard, O. (Ole), Ostrowski, M. (Matias), Park, J. (Jaesung), Pegtel, D.M. (D. Michiel), Peinado, H. (Hector), Perut, F. (Francesca), Pfaffl, M.W. (Michael W), Phinney, D.G. (Donald G), Pieters, B.C.H. (Bartijn CH), Pink, R.C. (Ryan C), Pisetsky, D.S. (David S), Pogge von Strandmann, E. (Elke), Polakovicova, I. (Iva), Poon, I.K.H. (Ivan KH), Powell, B.H. (Bonita H), Prada, I. (Ilaria), Pulliam, L. (Lynn), Quesenberry, P. (Peter), Radeghieri, A. (Annalisa), Raffai, R.L. (Robert L), Raimondo, S. (Stefania), Rak, J. (Janusz), Ramirez, M.I. (Marcel I.), Raposo, L. (Luís), Rayyan, M.S. (Morsi S), Regev-Rudzki, N. (Neta), Ricklefs, F.L. (Franz L), Robbins, P.D. (Paul D), Roberts, D.D. (David D), Rodrigues, S.C. (Silvia C), Rohde, E. (Eva), Rome, S. (Sophie), Rouschop, K.M.A. (Kasper MA), Rughetti, A. (Aurelia), Russell, A.E. (Ashley E), Saá, P. (Paula), Sahoo, S. (Susmita), Salas-Huenuleo, E. (Edison), Sánchez, C. (Catherine), Saugstad, J.A. (Julie A), Saul, M.J. (Meike J), Schiffelers, R.M. (Raymond), Schneider, R. (Raphael), Schøyen, T.H. (Tine Hiorth), Scott, A. (Aaron), Shahaj, E. (Eriomina), Sharma, S. (Shivani), Shatnyeva, O. (Olga), Shekari, F. (Faezeh), Shelke, G.V. (Ganesh Vilas), Shetty, A.K. (Ashok K), Shiba, K. (Kiyotaka), Siljander, P. (Pia), Silva, A.M. (Andreia M), Skowronek, A. (Agata), Snyder, O.L. (Orman L), Soares, R.P. (Rodrigo Pedro), Sódar, B.W. (Barbara W), Soekmadji, C. (Carolina), Sotillo, J. (Javier), Stahl, P.D. (Philip D), Stoorvogel, W. (Willem), Stott, S.L. (Shannon L), Strasser, E.F. (Erwin F), Swift, S. (Simon), Tahara, H. (Hidetoshi), Tewari, M. (Muneesh), Timms, K. (Kate), Tiwari, S. (Swasti), Tixeira, R. (Rochelle), Tkach, M. (Mercedes), Toh, W.S. (Wei Seong), Tomasini, R. (Richard), Torrecilhas, A.C. (Ana Claudia), Tosar, J.P. (Juan Pablo), Toxavidis, V. (Vasilis), Urbanelli, L. (Lorena), Vader, P. (Pieter), Balkom, B.W.M. (Bas) van, van der Grein, S.G. (Susanne G), Van Deun, J. (Jan), van Herwijnen, M.J.C. (Martijn JC), Van Keuren-Jensen, K. (Kendall), van Niel, G. (Guillaume), Royen, M.E. (Martin), van Wijnen, A.J. (Andre J), Vasconcelos, M.H. (M Helena), Vechetti, I.J. (Ivan J), Veit, T.D. (Tiago D), Vella, L.J. (Laura J.), Velot, É. (Émilie), Verweij, F.J. (Frederik J), Vestad, B. (Beate), Viñas, J.L. (Jose L), Visnovitz, T. (Tamás), Vukman, K.V. (Krisztina V), Wahlgren, J. (Jessica), Watson, D.C. (Dionysios C), Wauben, M.H.M. (Marca), Weaver, A. (Alissa), Webber, J.P. (Jason P), Weber, V. (Viktoria), Wehman, A.M. (Ann M), Weiss, D.J. (Daniel J), Welsh, J.A. (Joshua A), Wendt, S. (Sebastian), Wheelock, A.M. (Asa M), Wiener, Z. (Zoltán), Witte, L. (Leonie), Wolfram, J. (Joy), Xagorari, A. (Angeliki), Xander, P. (Patricia), Xu, J. (Jing), Yan, X. (Xiaomei), Yáñez-Mó, M. (María), Yin, H. (Hang), Yuana, Y., Zappulli, V. (Valentina), Zarubova, J. (Jana), Žėkas, V. (Vytautas), Zhang, J.-Y. (Jian-ye), Zhao, Z. (Zezhou), Zheng, L. (Lei), Zheutlin, A.R. (Alexander R), Zickler, A.M. (Antje M), Zimmermann, P. (Pascale), Zivkovic, A.M. (Angela M), Zocco, D. (Davide), Zuba-Surma, E.K. (Ewa K), Thery, C., Witwer, K. (Kenneth), Aikawa, E. (Elena), Alcaraz, M.J. (Maria Jose), Anderson, J.D. (Johnathon D), Andriantsitohaina, R. (Ramaroson), Antoniou, A. (Anna), Arab, T. (Tanina), Archer, F. (Fabienne), Atkin-Smith, G.K. (Georgia K), Ayre, D.C. (D Craig), Bach, J.-M. (Jean-Marie), Bachurski, D. (Daniel), Baharvand, H. (Hossein), Balaj, L. (Leonora), Baldacchino, S. (Shawn), Bauer, N.N. (Natalie N), Baxter, A.A. (Amy A), Bebawy, M. (Mary), Beckham, C. (Carla), Bedina Zavec, A. (Apolonija), Benmoussa, A. (Abderrahim), Berardi, A.C. (Anna C), Bergese, P. (Paolo), Bielska, E. (Ewa), Blenkiron, C. (Cherie), Bobis-Wozowicz, S. (Sylwia), Boilard, E. (Eric), Boireau, W. (Wilfrid), Bongiovanni, A. (Antonella), Borràs, F.E. (Francesc), Bosch, S. (Steffi), Boulanger, C.M. (Chantal), Breakefield, X. (Xandra), Breglio, A.M. (Andrew M), Brennan, M.Á. (Meadhbh Á), Brigstock, D.R. (David R), Brisson, A. (Alain), Broekman, M.L.D. (Marike), Bromberg, J.F. (Jacqueline F), Bryl-Górecka, P. (Paulina), Buch, S. (Shilpa), Buck, A.H. (Amy H), Burger, D. (Dylan), Busatto, S. (Sara), Buschmann, D. (Dominik), Bussolati, B. (Benedetta), Buzas, E. (Edit), Byrd, J.B. (James Bryan), Camussi, G. (Giovanni), Carter, D.R.F. (David RF), Caruso, S. (Sarah), Chamley, L.W. (Lawrence W), Chang, Y.-T. (Yu-Ting), Chaudhuri, A.D. (Amrita Datta), Chen, C. (Chihchen), Chen, S. (Shuai), Cheng, L. (Lesley), Chin, A.R. (Andrew R), Clayton, A. (Aled), Clerici, S.P. (Stefano P), Cocks, A. (Alex), Cocucci, E. (Emanuele), Coffey, R.J. (Robert J), Cordeiro-da-Silva, A. (Anabela), Couch, Y. (Yvonne), Coumans, F.A.W. (Frank AW), Coyle, B. (Beth), Crescitelli, R. (Rossella), Criado, M.F. (Miria Ferreira), D’Souza-Schorey, C. (Crislyn), Das, S. (Saumya), de Candia, P. (Paola), De Santana, E.F. (Eliezer F), De Wever, O. (Olivier), Del Portillo, H. (Hernando), Demaret, T. (Tanguy), Deville, S. (Sarah), Devitt, A. (Andrew), Dhondt, B. (Bert), Di Vizio, D. (Dolores), Dieterich, L.C. (Lothar C), Dolo, V. (Vincenza), Dominguez Rubio, A.P. (Ana Paula), Dominici, M. (Massimo), Dourado, M.R. (Mauricio R), Driedonks, T.A.P. (Tom AP), Duarte, F.V. (Filipe V), Duncan, H.M. (Heather M), Eichenberger, R.M. (Ramon M), Ekström, K. (Karin), EL Andaloussi, S. (Samir), Elie-Caille, C. (Celine), Erdbrügger, U. (Uta), Falcon-Perez, J.M. (Juan), Fatima, F. (Farah), Fish, J.E. (Jason E), Flores-Bellver, M. (Miguel), Försönits, A. (András), Frelet-Barrand, A. (Annie), Fricke, F. (Fabia), Fuhrmann, G. (Gregor), Gabrielsson, S. (Susanne), Gámez-Valero, A. (Ana), Gardiner, C. (Chris), Gärtner, K. (Kathrin), Gaudin, R. (Raphael), Gho, Y.S. (Yong Song), Giebel, B. (B.), Gilbert, C. (Caroline), Gimona, M. (Mario), Giusti, I. (Ilaria), Goberdhan, D.C.I. (Deborah CI), Görgens, A. (André), Gorski, S.M. (Sharon M), Greening, D.W. (David W.), Gross, J.C. (Julia Christina), Gualerzi, A. (Alice), Gupta, G.N. (Gopal N), Gustafson, D. (Dakota), Handberg, A. (Aase), Haraszti, R.A. (Reka A), Harrison, P. (Paul), Hegyesi, H. (Hargita), Hendrix, A. (An), Hill, A.F. (Andrew F), Hochberg, F.H. (Fred H), Hoffmann, K.F. (Karl F), Holder, B. (Beth), Holthofer, H. (Harry), Hosseinkhani, B. (Baharak), Hu, G. (Guoku), Huang, Y. (Yiyao), Huber, V. (Veronica), Hunt, S. (Stuart), Ibrahim, A.G.-E. (Ahmed Gamal-Eldin), Ikezu, T. (Tsuneya), Inal, J.M. (Jameel), Isin, M. (Mustafa), Ivanova, A. (Alena), Jackson, H.K. (Hannah K), Jacobsen, S. (Soren), Jay, S.M. (Steven M), Jayachandran, M. (Muthuvel), Jenster, G.W. (Guido), Jiang, L. (Lanzhou), Johnson, S.M. (Suzanne M), Jones, J.C. (Jennifer C), Jong, A. (Ambrose), Jovanovic-Talisman, T. (Tijana), Jung, S. (Stephanie), Kalluri, R. (Raghu), Kano, S.-I. (Shin-ichi), Kaur, S. (Sukhbir), Kawamura, Y. (Yumi), Keller, E.T. (Evan T), Khamari, D. (Delaram), Khomyakova, E. (Elena), Khvorova, A. (Anastasia), Kierulf, P. (Peter), Kim, K.P. (Kwang Pyo), Kislinger, T. (Thomas), Klingeborn, M. (Mikael), Klinke, D.J. (David J), Kornek, M. (Miroslaw), Kosanović, M.M. (Maja M), Kovács, Á.F. (Árpád Ferenc), Krämer-Albers, E.-M. (Eva-Maria), Krasemann, S. (Susanne), Krause, M. (Mirja), Kurochkin, I.V. (Igor V), Kusuma, G.D. (Gina D), Kuypers, S. (Sören), Laitinen, S. (Saara), Langevin, S.M. (Scott M), Languino, L.R. (Lucia R), Lannigan, J. (Joanne), Lässer, C. (Cecilia), Laurent, L.C. (Louise C), Lavieu, G. (Gregory), Lázaro-Ibáñez, E. (Elisa), Le Lay, S. (Soazig), Lee, M.-S. (Myung-Shin), Lee, Y.X.F. (Yi Xin Fiona), Lemos, D.S. (Debora S), Lenassi, M. (Metka), Leszczynska, A. (Aleksandra), Li, I.T.S. (Isaac TS), Liao, K. (Ke), Libregts, S.F. (Sten), Ligeti, E. (Erzsebet), Lim, R. (Rebecca), Lim, S.K. (Sai Kiang), Linē, A. (Aija), Linnemannstöns, K. (Karen), Llorente, A. (Alicia), Lombard, C.A. (Catherine A), Lorenowicz, M.J. (Magdalena J), Lörincz, Á.M. (Ákos M), Lötvall, J. (Jan), Lovett, J. (Jason), Lowry, M.C. (Michelle C), Loyer, X. (Xavier), Lu, Q. (Quan), Lukomska, B. (Barbara), Lunavat, T.R. (Taral R), Maas, S.L.N. (Sybren), Malhi, H. (Harmeet), Marcilla, A. (Antonio), Mariani, J. (Jacopo), Mariscal, J. (Javier), Martens-Uzunova, E.S. (Elena), Martin-Jaular, L. (Lorena), Martinez, M.C. (M Carmen), Martins, V.R. (Vilma Regina), Mathieu, M. (Mathilde), Mathivanan, S. (Suresh), Maugeri, M. (Marco), McGinnis, L.K. (Lynda K), McVey, M.J. (Mark J), Meckes, D.G. (David G), Meehan, K.L. (Katie L), Mertens, I. (Inge), Minciacchi, V.R. (Valentina R), Möller, A. (Andreas), Møller Jørgensen, M. (Malene), Morales-Kastresana, A. (Aizea), Morhayim, J. (Jess), Mullier, F. (Francois), Muraca, M. (Maurizio), Musante, L. (Luca), Mussack, V. (Veronika), Muth, D.C. (Dillon C), Myburgh, K.H. (Kathryn H), Najrana, T. (Tanbir), Nawaz, M. (Muhammad), Nazarenko, I. (Irina), Nejsum, P. (Peter), Neri, C. (Christian), Neri, T. (Tommaso), Nieuwland, C.C.M. (Carolien) van, Nimrichter, L. (Leonardo), Nolan, J.P. (John P), Nolte-’t Hoen, E.N.M. (Esther NM), Hooten, N.N. (Nicole Noren), O’Driscoll, L. (Lorraine), O’Grady, T. (Tina), O’Loghlen, A. (Ana), Ochiya, T. (Takahiro), Olivier, M. (Martin), Ortiz, A. (Alberto), Ortiz, L.A. (Luis A), Osteikoetxea, X. (Xabier), Ostegaard, O. (Ole), Ostrowski, M. (Matias), Park, J. (Jaesung), Pegtel, D.M. (D. Michiel), Peinado, H. (Hector), Perut, F. (Francesca), Pfaffl, M.W. (Michael W), Phinney, D.G. (Donald G), Pieters, B.C.H. (Bartijn CH), Pink, R.C. (Ryan C), Pisetsky, D.S. (David S), Pogge von Strandmann, E. (Elke), Polakovicova, I. (Iva), Poon, I.K.H. (Ivan KH), Powell, B.H. (Bonita H), Prada, I. (Ilaria), Pulliam, L. (Lynn), Quesenberry, P. (Peter), Radeghieri, A. (Annalisa), Raffai, R.L. (Robert L), Raimondo, S. (Stefania), Rak, J. (Janusz), Ramirez, M.I. (Marcel I.), Raposo, L. (Luís), Rayyan, M.S. (Morsi S), Regev-Rudzki, N. (Neta), Ricklefs, F.L. (Franz L), Robbins, P.D. (Paul D), Roberts, D.D. (David D), Rodrigues, S.C. (Silvia C), Rohde, E. (Eva), Rome, S. (Sophie), Rouschop, K.M.A. (Kasper MA), Rughetti, A. (Aurelia), Russell, A.E. (Ashley E), Saá, P. (Paula), Sahoo, S. (Susmita), Salas-Huenuleo, E. (Edison), Sánchez, C. (Catherine), Saugstad, J.A. (Julie A), Saul, M.J. (Meike J), Schiffelers, R.M. (Raymond), Schneider, R. (Raphael), Schøyen, T.H. (Tine Hiorth), Scott, A. (Aaron), Shahaj, E. (Eriomina), Sharma, S. (Shivani), Shatnyeva, O. (Olga), Shekari, F. (Faezeh), Shelke, G.V. (Ganesh Vilas), Shetty, A.K. (Ashok K), Shiba, K. (Kiyotaka), Siljander, P. (Pia), Silva, A.M. (Andreia M), Skowronek, A. (Agata), Snyder, O.L. (Orman L), Soares, R.P. (Rodrigo Pedro), Sódar, B.W. (Barbara W), Soekmadji, C. (Carolina), Sotillo, J. (Javier), Stahl, P.D. (Philip D), Stoorvogel, W. (Willem), Stott, S.L. (Shannon L), Strasser, E.F. (Erwin F), Swift, S. (Simon), Tahara, H. (Hidetoshi), Tewari, M. (Muneesh), Timms, K. (Kate), Tiwari, S. (Swasti), Tixeira, R. (Rochelle), Tkach, M. (Mercedes), Toh, W.S. (Wei Seong), Tomasini, R. (Richard), Torrecilhas, A.C. (Ana Claudia), Tosar, J.P. (Juan Pablo), Toxavidis, V. (Vasilis), Urbanelli, L. (Lorena), Vader, P. (Pieter), Balkom, B.W.M. (Bas) van, van der Grein, S.G. (Susanne G), Van Deun, J. (Jan), van Herwijnen, M.J.C. (Martijn JC), Van Keuren-Jensen, K. (Kendall), van Niel, G. (Guillaume), Royen, M.E. (Martin), van Wijnen, A.J. (Andre J), Vasconcelos, M.H. (M Helena), Vechetti, I.J. (Ivan J), Veit, T.D. (Tiago D), Vella, L.J. (Laura J.), Velot, É. (Émilie), Verweij, F.J. (Frederik J), Vestad, B. (Beate), Viñas, J.L. (Jose L), Visnovitz, T. (Tamás), Vukman, K.V. (Krisztina V), Wahlgren, J. (Jessica), Watson, D.C. (Dionysios C), Wauben, M.H.M. (Marca), Weaver, A. (Alissa), Webber, J.P. (Jason P), Weber, V. (Viktoria), Wehman, A.M. (Ann M), Weiss, D.J. (Daniel J), Welsh, J.A. (Joshua A), Wendt, S. (Sebastian), Wheelock, A.M. (Asa M), Wiener, Z. (Zoltán), Witte, L. (Leonie), Wolfram, J. (Joy), Xagorari, A. (Angeliki), Xander, P. (Patricia), Xu, J. (Jing), Yan, X. (Xiaomei), Yáñez-Mó, M. (María), Yin, H. (Hang), Yuana, Y., Zappulli, V. (Valentina), Zarubova, J. (Jana), Žėkas, V. (Vytautas), Zhang, J.-Y. (Jian-ye), Zhao, Z. (Zezhou), Zheng, L. (Lei), Zheutlin, A.R. (Alexander R), Zickler, A.M. (Antje M), Zimmermann, P. (Pascale), Zivkovic, A.M. (Angela M), Zocco, D. (Davide), and Zuba-Surma, E.K. (Ewa K)

Abstract

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make the

Published
2019
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48. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Author

Thery, C, Witwer, KW, Aikawa, E, Jose Alcaraz, M, Anderson, JD, Andriantsitohaina, R, Antoniou, A, Arab, T, Archer, F, Atkin-Smith, GK, Ayre, DC, Bach, J-M, Bachurski, D, Baharvand, H, Balaj, L, Baldacchino, S, Bauer, NN, Baxter, AA, Bebawy, M, Beckham, C, Zavec, AB, Benmoussa, A, Berardi, AC, Bergese, P, Bielska, E, Blenkiron, C, Bobis-Wozowicz, S, Boilard, E, Boireau, W, Bongiovanni, A, Borras, FE, Bosch, S, Boulanger, CM, Breakefield, X, Breglio, AM, Brennan, MA, Brigstock, DR, Brisson, A, Broekman, MLD, Bromberg, JF, Bryl-Gorecka, P, Buch, S, Buck, AH, Burger, D, Busatto, S, Buschmann, D, Bussolati, B, Buzas, E, Byrd, JB, Camussi, G, Carter, DRF, Caruso, S, Chamley, LW, Chang, Y-T, Chen, C, Chen, S, Cheng, L, Chin, AR, Clayton, A, Clerici, SP, Cocks, A, Cocucci, E, Coffey, RJ, Cordeiro-da-Silva, A, Couch, Y, Coumans, FAW, Coyle, B, Crescitelli, R, Criado, MF, D'Souza-Schorey, C, Das, S, Chaudhuri, AD, de Candia, P, De Santana Junior, EF, De Wever, O, del Portillo, HA, Demaret, T, Deville, S, Devitt, A, Dhondt, B, Di Vizio, D, Dieterich, LC, Dolo, V, Dominguez Rubio, AP, Dominici, M, Dourado, MR, Driedonks, TAP, Duarte, F, Duncan, HM, Eichenberger, RM, Ekstrom, K, Andaloussi, SEL, Elie-Caille, C, Erdbrugger, U, Falcon-Perez, JM, Fatima, F, Fish, JE, Flores-Bellver, M, Forsonits, A, Frelet-Barrand, A, Fricke, F, Fuhrmann, G, Gabrielsson, S, Gamez-Valero, A, Gardiner, C, Gaertner, K, Gaudin, R, Gho, YS, Giebel, B, Gilbert, C, Gimona, M, Giusti, I, Goberdhan, DC, Goergens, A, Gorski, SM, Greening, DW, Gross, JC, Gualerzi, A, Gupta, GN, Gustafson, D, Handberg, A, Haraszti, RA, Harrison, P, Hegyesi, H, Hendrix, A, Hill, AF, Hochberg, FH, Hoffmann, KF, Holder, B, Holthofer, H, Hosseinkhani, B, Hu, G, Huang, Y, Huber, V, Hunt, S, Ibrahim, AG-E, Ikezu, T, Inal, JM, Isin, M, Ivanova, A, Jackson, HK, Jacobsen, S, Jay, SM, Jayachandran, M, Jenster, G, Jiang, L, Johnson, SM, Jones, JC, Jong, A, Jovanovic-Talisman, T, Jung, S, Kalluri, R, Kano, S-I, Kaur, S, Kawamura, Y, Keller, ET, Khamari, D, Khomyakova, E, Khvorova, A, Kierulf, P, Kim, KP, Kislinger, T, Klingeborn, M, Klinke, DJ, Kornek, M, Kosanovic, MM, Kovacs, AF, Kraemer-Albers, E-M, Krasemann, S, Krause, M, Kurochkin, I, Kusuma, GD, Kuypers, S, Laitinen, S, Langevin, SM, Languino, LR, Lannigan, J, Lasser, C, Laurent, LC, Lavieu, G, Lazaro-Ibanez, E, Le Lay, S, Lee, M-S, Lee, YXF, Lemos, DS, Lenassi, M, Leszczynska, A, Li, ITS, Liao, K, Libregts, SF, Ligeti, E, Lim, R, Lim, SK, Line, A, Linnemannstoens, K, Llorente, A, Lombard, CA, Lorenowicz, MJ, Lorincz, AM, Lotvall, J, Lovett, J, Lowry, MC, Loyer, X, Lu, Q, Lukomska, B, Lunavat, TR, Maas, SLN, Malhi, H, Marcilla, A, Mariani, J, Mariscal, J, Martens-Uzunova, ES, Martin-Jaular, L, Martinez, MC, Martins, VR, Mathieu, M, Mathivanan, S, Maugeri, M, McGinnis, LK, McVey, MJ, Meckes, DG, Meehan, KL, Mertens, I, Minciacchi, VR, Moller, A, Jorgensen, MM, Morales-Kastresana, A, Morhayim, J, Mullier, F, Muraca, M, Musante, L, Mussack, V, Muth, DC, Myburgh, KH, Najrana, T, Nawaz, M, Nazarenko, I, Nejsum, P, Neri, C, Neri, T, Nieuwland, R, Nimrichter, L, Nolan, JP, Nolte-'t Hoen, ENM, Noren Hooten, N, O'Driscoll, L, O'Grady, T, O'Loghlen, A, Ochiya, T, Olivier, M, Ortiz, A, Ortiz, LA, Osteikoetxea, X, Ostegaard, O, Ostrowski, M, Park, J, Pegtel, DM, Peinado, H, Perut, F, Pfaffl, MW, Phinney, DG, Pieters, BCH, Pink, RC, Pisetsky, DS, von Strandmann, EP, Polakovicova, I, Poon, IKH, Powell, BH, Prada, I, Pulliam, L, Quesenberry, P, Radeghieri, A, Raffai, RL, Raimondo, S, Rak, J, Ramirez, M, Raposo, G, Rayyan, MS, Regev-Rudzki, N, Ricklefs, FL, Robbins, PD, Roberts, DD, Rodrigues, SC, Rohde, E, Rome, S, Rouschop, KMA, Rughetti, A, Russell, AE, Saa, P, Sahoo, S, Salas-Huenuleo, E, Sanchez, C, Saugstad, JA, Saul, MJ, Schiffelers, RM, Schneider, R, Schoyen, TH, Scott, A, Shahaj, E, Sharma, S, Shatnyeva, O, Shekari, F, Shelke, GV, Shetty, AK, Shiba, K, Siljander, PR-M, Silva, AM, Skowronek, A, Snyder, OL, Soares, RP, Sodar, BW, Soekmadji, 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Abstract

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.

Published
2018

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