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4. Personalized rTMS for Depression: A Review

Author

Gogulski, Juha, Ross, Jessica M., Talbot, Austin, Cline, Christopher, Donati, Francesco L, Munot, Saachi, Kim, Naryeong, Gibbs, Ciara, Bastin, Nikita, Yang, Jessica, Minasi, Christopher B., Sarkar, Manjima, Truong, Jade, and Keller, Corey J

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

Personalized treatments are gaining momentum across all fields of medicine. Precision medicine can be applied to neuromodulatory techniques, where focused brain stimulation treatments such as repetitive transcranial magnetic stimulation (rTMS) are used to modulate brain circuits and alleviate clinical symptoms. rTMS is well-tolerated and clinically effective for treatment-resistant depression (TRD) and other neuropsychiatric disorders. However, despite its wide stimulation parameter space (location, angle, pattern, frequency, and intensity can be adjusted), rTMS is currently applied in a one-size-fits-all manner, potentially contributing to its suboptimal clinical response (~50%). In this review, we examine components of rTMS that can be optimized to account for inter-individual variability in neural function and anatomy. We discuss current treatment options for TRD, the neural mechanisms thought to underlie treatment, differences in FDA-cleared devices, targeting strategies, stimulation parameter selection, and adaptive closed-loop rTMS to improve treatment outcomes. We suggest that better understanding of the wide and modifiable parameter space of rTMS will greatly improve clinical outcome.

Published
2022

5. Upskilling consumers for the digital health era: a content analysis of resources for consumer representative training

Author

Jing Hern Kevin Poh, Clare Mullen, Sonali Munot, Pip Brennan, Clara Chow, and Edel O’Hagan

Subjects
Consumer, digital health, educational resources, interoperability, data security, Public aspects of medicine, RA1-1270, Special aspects of education, LC8-6691
Abstract

Background In the past decade digital health research has exponentially increased. Concurrently, consumer involvement in digital health research has grown, but often relegated to late stages like user experience testing, for which a fundamental capability is digital health literacy. In-depth knowledge about how digital health tools and platforms are developed, evaluated, and implemented is necessary for higher levels of meaningful consumer involvement in digital health research. It is unclear what resources are freely available to consumer representatives and advocates to learn how digital health tools and platforms are developed, evaluated, and implemented.Aim To examine what freely available resources are available for consumers to learn how digital health tools and platforms are developed, evaluated, and implemented.Methods This was a content analysis study. Keywords representing digital health were identified in an iterative process with consumer advocate members of the research team. Researchers compiled a list of possible online resources where relevant educational material could be found. One investigator searched these resources in February 2024, recording website URLs and keyword frequencies. Keyword context was assessed to ensure alignment with study eligibility criteria. Data extraction was performed independently by two investigators with discrepancies resolved through discussion.Results We reduced an initial list of 129 keywords, to 13 MeSH headings to include in the initial search. This number increased to 23 keywords searched in a subsequent refined search. We searched 21 websites; 13 were from Australian non-government organizations(NGOs), with 11 were hosted by health consumer organizations. Government websites(n = 3), a cooperative website(n = 1), and international websites(n = 4) comprised the remainder. The digital health keywords most commonly found were digital health (n = 6444 instances), followed by data security (n = 4863 instances). When these keywords were paired with the keyword “consumer” we found limited resources to upskill in the development, evaluation, and implementation of digital health tools.Discussion The extent of consumer involvement in digital health research is compromised due to limited available resources to upskill consumer representatives and advocates. This poses a challenge for consumer involvement in digital health research as digital health technologies are ubiquitous yet evolving.

Published
2024
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8. Evaluation of Metronomic Therapy as a Low-Cost, Sustainable, Standard-of-Care Option in Desmoid Fibromatosis: Real-World Data From a Tertiary Care Center in India

Author

Jyoti Bajpai, Pritesh Munot, Kishore Kota, Gaurav Gupta, Kunal Gala, Aashish Gulia, Bharat Rekhi, Nehal Khanna, Nitin Shetty, Prabhat Bhargava, Sujay Srinivas, Vikas Ostwal, Vijay Patil, Vanita Noronha, Suyash Kulkarni, Siddharth Laskar, Kumar Prabhash, Girish Chinnaswamy, Sudeep Gupta, and Shripad Banavali

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

PURPOSEDesmoid fibromatosis (DF) is a locally aggressive tumor with low mortality but significant morbidity. There is a lack of standard of care, and existing therapies are associated with significant barriers including access, cost, and toxicities. This study aimed to explore the efficacy and safety of the metronomic therapy (MT) in DF in a large, homogenous cohort from India.PATIENTS AND METHODSThis study involved histologically confirmed DF cases treated with MT comprising vinblastine (6 mg) and methotrexate (15 mg) both once a week, and tamoxifen (40 mg/m2) in two divided doses once daily between 2002 and 2018.RESULTSThere were 315 patients with a median age of 27 years; the commonest site was extremity (142 of 315; 45.0%). There were 159 (50.1%) male patients. Of the 123 (39.0%) prior treated patients, 119 had surgery. Of 315 patients, 263 (83.5%) received treatment at our institute (MT—151, 77—local treatment, 9—tyrosine kinase inhibitor, and 26 were observed). Among the MT cohort (n = 163, 61.2%), at a median follow-up of 36 (0.5-186) months, the 3-year progression-free and overall survival were 81.1% (95% CI, 74.3 to 88.4) and 99.2% (95% CI, 97.6 to 100), respectively. There were 35% partial responses. Ninety-two patients (56.4%) completed 1-year therapy, which was an independent prognosticator (P < .0001; hazard ratio, 0.177 [95% CI, 0.083 to 0.377]). MT was well tolerated. Predominant grade ≥3 toxicities were febrile neutropenia, 12 (7.4%) without any chemotoxicity-related death. The annual cost of MT was $130 US dollars.CONCLUSIONThe novel, low-cost MT qualifies as one of the effective, less toxic, sustainable, standard-of-care options for the treatment of DF with global reach and merits wide recognition.

Published
2024
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9. Optimizing fluconazole-embedded transfersomal gel for enhanced antifungal activity and compatibility studies

Author

Zhiqiang Cheng, Ujjwala Kandekar, Xiaoshi Ma, Vishal Bhabad, Ashlesha Pandit, Liming Liu, Jiping Luo, Neha Munot, Trushal Chorage, Abhinandan Patil, Sandip Patil, and Liang Tao

Subjects
transfersomes, fluconazole, topical application, transfersomal gel, ex-vivo studies, Therapeutics. Pharmacology, RM1-950
Abstract

Fungal infections are of major concern all over the globe, and fluconazole is the most prevalently used drug to treat it. The goal of this research work was to formulate a fluconazole-embedded transfersomal gel for the treatment of fungal infections. A compatibility study between fluconazole and soya lecithin was performed by differential scanning calorimetry (DSC). Transfersomes were formulated by a thin-film hydration technique using soya lecithin and Span 80. A central composite design was adopted to prepare different formulations. Soya lecithin and Span 80 were chosen as independent variables, and the effect of these variables was studied on in vitro drug diffusion. Formulations were evaluated for entrapment efficiency and in vitro drug diffusion. The results of in vitro drug diffusion were analyzed using the analysis of variance (ANOVA) test. Optimized formulation was prepared based on the overlay plot and evaluated by scanning electron microscopy, DSC, vesicle size, polydispersity index (PDI), zeta potential, and in vitro drug diffusion studies. An optimized formulation was loaded into xanthan gum gel base and evaluated for pH, viscosity, in vitro and ex vivo drug diffusion, and antifungal activity. DSC studies revealed compatibility between fluconazole and soya lecithin. Entrapment efficiency and in vitro drug diffusion of various formulations ranged between 89.92% ± 0.20% to 97.28% ± 0.42% and 64% ± 1.56% to 85% ± 2.05%, respectively. A positive correlation was observed between in vitro drug diffusion and Span 80; conversely, a negative correlation was noted with soya lecithin. Entrapment efficiency, particle size, zeta potential, PDI, and drug diffusion of optimized formulation were 95.0% ± 2.2%, 397 ± 2 nm, −38 ± 5 mV, 0.43%, and 81 % ± 2%, respectively. SEM images showed well-distributed spherical-shaped transfersomes. In vitro, ex vivo drug diffusion and antifungal studies were conclusive of better diffusion and enhanced antifungal potential fluconazole in transfersomal formulation.

Published
2024
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10. SARS-CoV-2 infection induces epigenetic changes in the LTR69 subfamily of endogenous retroviruses

Author

Ankit Arora, Jan Eric Kolberg, Smitha Srinivasachar Badarinarayan, Natalia Savytska, Daksha Munot, Martin Müller, Veronika Krchlíková, Daniel Sauter, and Vikas Bansal

Subjects
SARS-CoV-2, Transposable elements, Endogenous retroviruses, Solo-LTRs, LTR69, Genetics, QH426-470
Abstract

Abstract Accumulating evidence suggests that endogenous retroviruses (ERVs) play an important role in the host response to infection and the development of disease. By analyzing ChIP-sequencing data sets, we show that SARS-CoV-2 infection induces H3K27 acetylation of several loci within the LTR69 subfamily of ERVs. Using functional assays, we identified one SARS-CoV-2-activated LTR69 locus, termed Dup69, which exhibits regulatory activity and is responsive to the transcription factors IRF3 and p65/RELA. LTR69_Dup69 is located about 500 bp upstream of a long non-coding RNA gene (ENSG00000289418) and within the PTPRN2 gene encoding a diabetes-associated autoantigen. Both ENSG00000289418 and PTPRN2 showed a significant increase in expression upon SARS-CoV-2 infection. Thus, our study sheds light on the interplay of exogenous with endogenous viruses and helps to understand how ERVs regulate gene expression during infection.

Published
2023
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14. Automated Detection of Diabetes From Exhaled Human Breath Using Deep Hybrid Architecture

Author

Navaneeth Bhaskar, Vinayak Bairagi, Ekkarat Boonchieng, and Mousami V. Munot

Subjects
Acetone, breath, convolutional neural network, correlation, deep learning, diabetes, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

In this paper, we have proposed an automated medical system for detecting type 2 diabetes from exhaled breath. Human breath can be used as a diagnostic sample for detecting many diseases as it contains many gases that are dissolved in the blood. Breath-based analysis stands out among the different non-invasive ways of detection as it provides more accurate predictions and offers many advantages. In this work, the concentration of acetone in the exhaled breath is analysed to detect type 2 diabetes. A new sensing module consisting of an array of sensors is implemented for monitoring the acetone concentration to detect the disease. Deep learning algorithms like Convolutional Neural Networks (CNN) are normally used to automatically analyse medical data to make predictions. Even though the CNN performs well, a few modifications to the network layout can further improve the classification accuracy of the learning model. To analyse the sensor signals to generate predictions, a new deep hybrid Correlational Neural Network (CORNN) is designed and implemented in this research. The proposed detection approach and deep learning algorithm offer improved accuracy when compared to other non-invasive techniques.

Published
2023
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15. Stratification of Length of Stay Prediction following Surgical Cytoreduction in Advanced High-Grade Serous Ovarian Cancer Patients Using Artificial Intelligence; the Leeds L-AI-OS Score

Author

Alexandros Laios, Daniel Lucas Dantas De Freitas, Gwendolyn Saalmink, Yong Sheng Tan, Racheal Johnson, Albina Zubayraeva, Sarika Munot, Richard Hutson, Amudha Thangavelu, Tim Broadhead, David Nugent, Evangelos Kalampokis, Kassio Michell Gomes de Lima, Georgios Theophilou, and Diederick De Jong

Subjects
machine learning, deep learning, artificial intelligence, surgical cytoreduction, epithelial ovarian cancer, length of stay, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

(1) Background: Length of stay (LOS) has been suggested as a marker of the effectiveness of short-term care. Artificial Intelligence (AI) technologies could help monitor hospital stays. We developed an AI-based novel predictive LOS score for advanced-stage high-grade serous ovarian cancer (HGSOC) patients following cytoreductive surgery and refined factors significantly affecting LOS. (2) Methods: Machine learning and deep learning methods using artificial neural networks (ANN) were used together with conventional logistic regression to predict continuous and binary LOS outcomes for HGSOC patients. The models were evaluated in a post-hoc internal validation set and a Graphical User Interface (GUI) was developed to demonstrate the clinical feasibility of sophisticated LOS predictions. (3) Results: For binary LOS predictions at differential time points, the accuracy ranged between 70–98%. Feature selection identified surgical complexity, pre-surgery albumin, blood loss, operative time, bowel resection with stoma formation, and severe postoperative complications (CD3–5) as independent LOS predictors. For the GUI numerical LOS score, the ANN model was a good estimator for the standard deviation of the LOS distribution by ± two days. (4) Conclusions: We demonstrated the development and application of both quantitative and qualitative AI models to predict LOS in advanced-stage EOC patients following their cytoreduction. Accurate identification of potentially modifiable factors delaying hospital discharge can further inform services performing root cause analysis of LOS.

Published
2022
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16. Examining training and attitudes to basic life support in multi-ethnic communities residing in New South Wales, Australia: A mixed-methods investigation

Author

Blake Angell, Clara K Chow, Julie Redfern, Christopher Semsarian, Adrian Bauman, Simone Marschner, Saurabh Kumar, Janet Bray, Guoyan Yang, Paul M Middleton, Pramesh Kovoor, Garry Jennings, Sonali Munot, Andrew Coggins, Linh Ngo, Emily J Rugel, Quan Minh Dang, and Zoe Rock

Subjects
Medicine
Abstract

Background Bystander response, including cardiopulmonary resuscitation (CPR), is critical to out-of-hospital cardiac arrest (OHCA) survival. Nearly 30% of Australian residents were born overseas, and little is known about their preparedness to perform CPR. In this mixed-methods study, we examined rates of training and willingness and barriers to performing CPR among immigrants in Australia.Methods First, we surveyed residents in New South Wales, Australia, using purposeful sampling to enrich immigrant populations. Multivariate logistic regression was used to examine the association between place of birth and willingness to perform CPR. Next, we conducted focus-group discussions with members of the region’s largest migrant groups to explore barriers and relevant societal or cultural factors.Results Of the 1267 survey participants (average age 49.6 years, 52% female), 60% were born outside Australia, most in Asia and 73% had lived in Australia for more than 10 years. Higher rates of previous CPR training were reported among Australian-born participants compared with South Asian-born and East Asian-born (77%, 35%, 48%, respectively, p

Published
2023
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17. Overview of T and D–T results in JET with ITER-like wall

Author

C.F. Maggi, D. Abate, N. Abid, P. Abreu, O. Adabonyan, M. Afzal, I. Ahmad, M. Akhtar, R. Albanese, S. Aleiferis, E. Alessi, P. Aleynikov, J. Alguacil, J. Alhage, M. Ali, H. Allen, M. Allinson, M. Alonzo, E. Alves, R. Ambrosino, E. Andersson Sundén, P. Andrew, M. Angelone, C. Angioni, I. Antoniou, L. Appel, C. Appelbee, C. Aramunde, M. Ariola, G. Arnoux, G. Artaserse, J.-F. Artaud, W. Arter, V. Artigues, F.J. Artola, A. Ash, O. Asztalos, D. Auld, F. Auriemma, Y. Austin, L. Avotina, J. Ayllón, E. Aymerich, A. Baciero, L. Bähner, F. Bairaktaris, I. Balboa, M. Balden, N. Balshaw, V.K. Bandaru, J. Banks, A. Banon Navarro, C. Barcellona, O. Bardsley, M. Barnes, R. Barnsley, M. Baruzzo, M. Bassan, A. Batista, P. Batistoni, L. Baumane, B. Bauvir, L. Baylor, C. Bearcroft, P. Beaumont, D. Beckett, A. Begolli, M. Beidler, N. Bekris, M. Beldishevski, E. Belli, F. Belli, S. Benkadda, J. Bentley, E. Bernard, J. Bernardo, M. Bernert, M. Berry, L. Bertalot, H. Betar, M. Beurskens, P.G. Bhat, S. Bickerton, J. Bielecki, T. Biewer, R. Bilato, P. Bílková, G. Birkenmeier, R. Bisson, J.P.S. Bizarro, P. Blatchford, A. Bleasdale, V. Bobkov, A. Boboc, A. Bock, G. Bodnar, P. Bohm, L. Bonalumi, N. Bonanomi, D. Bonfiglio, X. Bonnin, P. Bonofiglo, J. Booth, D. Borba, D. Borodin, I. Borodkina, T.O.S.J. Bosman, C. Bourdelle, M. Bowden, I. Božičević Mihalić, S.C. Bradnam, B. Breizman, S. Brezinsek, D. Brida, M. Brix, P. Brown, D. Brunetti, M. Buckley, J. Buermans, H. Bufferand, P. Buratti, A. Burckhart, A. Burgess, A. Buscarino, A. Busse, D. Butcher, G. Calabrò, L. Calacci, R. Calado, R. Canavan, B. Cannas, M. Cannon, M. Cappelli, S. Carcangiu, P. Card, A. Cardinali, S. Carli, P. Carman, D. Carnevale, B. Carvalho, I.S. Carvalho, P. Carvalho, I. Casiraghi, F.J. Casson, C. Castaldo, J.P. Catalan, N. Catarino, F. Causa, M. Cavedon, M. Cecconello, L. Ceelen, C.D. Challis, B. Chamberlain, R. Chandra, C.S. Chang, A. Chankin, B. Chapman, P. Chauhan, M. Chernyshova, A. Chiariello, G.-C. Chira, P. Chmielewski, A. Chomiczewska, L. Chone, J. Cieslik, G. Ciraolo, D. Ciric, J. Citrin, Ł. Ciupinski, R. Clarkson, M. Cleverly, P. Coates, V. Coccorese, R. Coelho, J.W. Coenen, I.H. Coffey, A. Colangeli, L. Colas, J. Collins, S. Conroy, C. Contré, N.J. Conway, D. Coombs, P. Cooper, S. Cooper, L. Cordaro, C. Corradino, Y. Corre, G. Corrigan, D. Coster, T. Craciunescu, S. Cramp, D. Craven, R. Craven, G. Croci, D. Croft, K. Crombé, T. Cronin, N. Cruz, A. Cufar, A. Cullen, A. Dal Molin, S. Dalley, P. David, A. Davies, J. Davies, S. Davies, G. Davis, K. Dawson, S. Dawson, I. Day, G. De Tommasi, J. Deane, M. Dearing, M. De Bock, J. Decker, R. Dejarnac, E. Delabie, E. de la Cal, E. de la Luna, D. Del Sarto, A. Dempsey, W. Deng, A. Dennett, G.L. Derks, G. De Temmerman, F. Devasagayam, P. de Vries, P. Devynck, A. di Siena, D. Dickinson, T. Dickson, M. Diez, P. Dinca, T. Dittmar, L. Dittrich, J. Dobrashian, T. Dochnal, A.J.H. Donné, W. Dorland, S. Dorling, S. Dormido-Canto, R. Dotse, D. Douai, S. Dowson, R. Doyle, M. Dreval, P. Drews, G. Drummond, Ph. Duckworth, H.G. Dudding, R. Dumont, P. Dumortier, D. Dunai, T. Dunatov, M. Dunne, I. Ďuran, F. Durodié, R. Dux, T. Eade, E. Eardley, J. Edwards, T. Eich, A. Eksaeva, H. El-Haroun, R.D. Ellis, G. Ellwood, C. Elsmore, S. Emery, G. Ericsson, B. Eriksson, F. Eriksson, J. Eriksson, L.G. Eriksson, S. Ertmer, G. Evans, S. Evans, E. Fable, D. Fagan, M. Faitsch, D. Fajardo Jimenez, M. Falessi, A. Fanni, T. Farmer, I. Farquhar, B. Faugeras, S. Fazinić, N. Fedorczak, K. Felker, R. Felton, H. Fernandes, D.R. Ferreira, J. Ferreira, G. Ferrò, J. Fessey, O. Février, O. Ficker, A.R. Field, A. Figueiredo, J. Figueiredo, A. Fil, N. Fil, P. Finburg, U. Fischer, G. Fishpool, L. Fittill, M. Fitzgerald, D. Flammini, J. Flanagan, S. Foley, N. Fonnesu, M. Fontana, J.M. Fontdecaba, L. Fortuna, E. Fortuna-Zalesna, M. Fortune, C. Fowler, P. Fox, O. Franklin, E. Fransson, L. Frassinetti, R. Fresa, D. Frigione, T. Fülöp, M. Furseman, S. Gabriellini, D. Gadariya, S. Gadgil, K. Gál, S. Galeani, A. Galkowski, D. Gallart, M. Gambrioli, T. Gans, J. Garcia, M. García-Muñoz, L. Garzotti, J. Gaspar, R. Gatto, P. Gaudio, D. Gear, T. Gebhart, S. Gee, M. Gelfusa, R. George, S.N. Gerasimov, R. Gerru, G. Gervasini, M. Gethins, Z. Ghani, M. Gherendi, P.-I. Gherghina, F. Ghezzi, L. Giacomelli, C. Gibson, L. Gil, M.R. Gilbert, A. Gillgren, E. Giovannozzi, C. Giroud, G. Giruzzi, J. Goff, V. Goloborodko, R. Gomes, J.-F. Gomez, B. Gonçalves, M. Goniche, J. Gonzalez-Martin, A. Goodyear, S. Gore, G. Gorini, T. Görler, N. Gotts, E. Gow, J.P. Graves, J. Green, H. Greuner, E. Grigore, F. Griph, W. Gromelski, M. Groth, C. Grove, R. Grove, N. Gupta, S. Hacquin, L. Hägg, A. Hakola, M. Halitovs, J. Hall, C.J. Ham, M. Hamed, M.R. Hardman, Y. Haresawa, G. Harrer, J.R. Harrison, D. Harting, D.R. Hatch, T. Haupt, J. Hawes, N.C. Hawkes, J. Hawkins, S. Hazael, J. Hearmon, P. Heesterman, P. Heinrich, M. Held, W. Helou, O. Hemming, S.S. Henderson, R. Henriques, R.B. Henriques, D. Hepple, J. Herfindal, G. Hermon, J.C. Hillesheim, K. Hizanidis, A. Hjalmarsson, A. Ho, J. Hobirk, O. Hoenen, C. Hogben, A. Hollingsworth, S. Hollis, E. Hollmann, M. Hölzl, M. Hook, M. Hoppe, J. Horáček, N. Horsten, A. Horton, L.D. Horton, L. Horvath, S. Hotchin, Z. Hu, Z. Huang, E. Hubenov, A. Huber, V. Huber, T. Huddleston, G.T.A. Huijsmans, Y. Husain, P. Huynh, A. Hynes, D. Iglesias, M.V. Iliasova, M. Imríšek, J. Ingleby, P. Innocente, V. Ioannou-Sougleridis, N. Isernia, I. Ivanova-Stanik, E. Ivings, S. Jachmich, T. Jackson, A.S. Jacobsen, P. Jacquet, H. Järleblad, A. Järvinen, F. Jaulmes, N. Jayasekera, F. Jenko, I. Jepu, E. Joffrin, T. Johnson, J. Johnston, C. Jones, E. Jones, G. Jones, L. Jones, T.T.C. Jones, A. Joyce, M. Juvonen, A. Kallenbach, P. Kalnina, D. Kalupin, P. Kanth, A. Kantor, A. Kappatou, O. Kardaun, J. Karhunen, E. Karsakos, Ye.O. Kazakov, V. Kazantzidis, D.L. Keeling, W. Kelly, M. Kempenaars, D. Kennedy, K. Khan, E. Khilkevich, C. Kiefer, H.-T. Kim, J. Kim, S.H. Kim, D.B. King, D.J. Kinna, V.G. Kiptily, A. Kirjasuo, K.K. Kirov, A. Kirschner, T. Kiviniemi, G. Kizane, C. Klepper, A. Klix, G. Kneale, M. Knight, P. Knight, R. Knights, S. Knipe, U. Knoche, M. Knolker, M. Kocan, F. Köchl, G. Kocsis, J.T.W. Koenders, Y. Kolesnichenko, Y. Kominis, M. Kong, B. Kool, V. Korovin, S.B. Korsholm, B. Kos, D. Kos, M. Koubiti, Y. Kovtun, E. Kowalska-Strzęciwilk, K. Koziol, Y. Krasikov, A. Krasilnikov, V. Krasilnikov, M. Kresina, A. Kreter, K. Krieger, A. Krivska, U. Kruezi, I. Książek, H. Kumpulainen, B. Kurzan, S. Kwak, O.J. Kwon, B. Labit, M. Lacquaniti, A. Lagoyannis, L. Laguardia, A. Laing, V. Laksharam, N. Lam, H.T. Lambertz, B. Lane, M. Langley, E. Lascas Neto, E. Łaszyńska, K.D. Lawson, A. Lazaros, E. Lazzaro, G. Learoyd, C. Lee, K. Lee, S. Leerink, T. Leeson, X. Lefebvre, H.J. Leggate, J. Lehmann, M. Lehnen, D. Leichtle, F. Leipold, I. Lengar, M. Lennholm, E. Leon Gutierrez, L.A. Leppin, E. Lerche, A. Lescinskis, S. Lesnoj, L. Lewin, J. Lewis, J. Likonen, Ch. Linsmeier, X. Litaudon, E. Litherland-Smith, F. Liu, T. Loarer, A. Loarte, R. Lobel, B. Lomanowski, P.J. Lomas, J. Lombardo, R. Lorenzini, S. Loreti, V.P. Loschiavo, M. Loughlin, T. Lowe, C. Lowry, T. Luce, R. Lucock, T. Luda Di Cortemiglia, M. Lungaroni, C.P. Lungu, T. Lunt, V. Lutsenko, B. Lyons, J. Macdonald, E. Macusova, R. Mäenpää, H. Maier, J. Mailloux, S. Makarov, P. Manas, A. Manning, P. Mantica, M.J. Mantsinen, J. Manyer, A. Manzanares, Ph. Maquet, M. Maraschek, G. Marceca, G. Marcer, C. Marchetto, O. Marchuk, A. Mariani, G. Mariano, M. Marin, A. Marin Roldan, M. Marinelli, T. Markovič, L. Marot, C. Marren, S. Marsden, S. Marsen, J. Marsh, R. Marshall, L. Martellucci, A.J. Martin, C. Martin, R. Martone, S. Maruyama, M. Maslov, M. Mattei, G.F. Matthews, D. Matveev, E. Matveeva, A. Mauriya, F. Maviglia, M. Mayer, M.-L. Mayoral, S. Mazzi, C. Mazzotta, R. McAdams, P.J. McCarthy, P. McCullen, R. McDermott, D.C. McDonald, D. McGuckin, V. McKay, L. McNamee, A. McShee, D. Mederick, M. Medland, S. Medley, K. Meghani, A.G. Meigs, S. Meitner, S. Menmuir, K. Mergia, S. Mianowski, P. Middleton, J. Mietelski, K. Mikszuta-Michalik, D. Milanesio, E. Milani, E. Militello-Asp, F. Militello, J. Milnes, A. Milocco, S. Minucci, I. Miron, J. Mitchell, J. Mlynář, V. Moiseenko, P. Monaghan, I. Monakhov, A. Montisci, S. Moon, R. Mooney, S. Moradi, R.B. Morales, L. Morgan, F. Moro, J. Morris, T. Mrowetz, L. Msero, S. Munot, A. Muñoz-Perez, M. Muraglia, A. Murari, A. Muraro, B. N’Konga, Y.S. Na, F. Nabais, R. Naish, F. Napoli, E. Nardon, V. Naulin, M.F.F. Nave, R. Neu, S. Ng, M. Nicassio, D. Nicolai, A.H. Nielsen, S.K. Nielsen, D. Nina, C. Noble, C.R. Nobs, M. Nocente, H. Nordman, S. Nowak, H. Nyström, J. O’Callaghan, M. O’Mullane, C. O’Neill, C. Olde, H.J.C. Oliver, R. Olney, J. Ongena, G.P. Orsitto, A. Osipov, R. Otin, N. Pace, L.W. Packer, E. Pajuste, D. Palade, J. Palgrave, O. Pan, N. Panadero, T. Pandya, E. Panontin, A. Papadopoulos, G. Papadopoulos, G. Papp, V.V. Parail, A. Parsloe, K. Paschalidis, M. Passeri, A. Patel, A. Pau, G. Pautasso, R. Pavlichenko, A. Pavone, E. Pawelec, C. Paz-Soldan, A. Peacock, M. Pearce, I.J. Pearson, E. Peluso, C. Penot, K. Pepperell, A. Perdas, T. Pereira, E. Perelli Cippo, C. Perez von Thun, D. Perry, P. Petersson, G. Petravich, N. Petrella, M. Peyman, L. Pigatto, M. Pillon, S. Pinches, G. Pintsuk, C. Piron, A. Pironti, F. Pisano, R. Pitts, U. Planck, N. Platt, V. Plyusnin, M. Podesta, G. Pokol, F.M. Poli, O.G. Pompilian, M. Poradzinski, M. Porkolab, C. Porosnicu, G. Poulipoulis, A.S. Poulsen, I. Predebon, A. Previti, D. Primetzhofer, G. Provatas, G. Pucella, P. Puglia, K. Purahoo, O. Putignano, T. Pütterich, A. Quercia, G. Radulescu, V. Radulovic, R. Ragona, M. Rainford, P. Raj, M. Rasinski, D. Rasmussen, J. Rasmussen, J.J. Rasmussen, A. Raso, G. Rattá, S. Ratynskaia, R. Rayaprolu, M. Rebai, A. Redl, D. Rees, D. Réfy, R. Reichle, H. Reimerdes, B.C.G. Reman, C. Reux, S. Reynolds, D. Rigamonti, E. Righi, F.G. Rimini, J. Risner, J.F. Rivero-Rodriguez, C.M. Roach, J. Roberts, R. Robins, S. Robinson, D. Robson, S. Rode, P. Rodrigues, P. Rodriguez-Fernandez, S. Romanelli, J. Romazanov, E. Rose, C. Rose-Innes, R. Rossi, S. Rowe, D. Rowlands, C. Rowley, M. Rubel, G. Rubinacci, G. Rubino, M. Rud, J. Ruiz Ruiz, F. Ryter, S. Saarelma, A. Sahlberg, M. Salewski, A. Salmi, R. Salmon, F. Salzedas, F. Sanchez, I. Sanders, D. Sandiford, F. Sanni, O. Sauter, P. Sauvan, G. Schettini, A. Shevelev, A.A. Schekochihin, K. Schmid, B.S. Schmidt, S. Schmuck, M. Schneider, P.A. Schneider, N. Schoonheere, R. Schramm, D. Scoon, S. Scully, M. Segato, J. Seidl, L. Senni, J. Seo, G. Sergienko, M. Sertoli, S.E. Sharapov, R. Sharma, A. Shaw, R. Shaw, H. Sheikh, U. Sheikh, N. Shi, P. Shigin, D. Shiraki, G. Sias, M. Siccinio, B. Sieglin, S.A. Silburn, A. Silva, C. Silva, J. Silva, D. Silvagni, D. Simfukwe, J. Simpson, P. Sirén, A. Sirinelli, H. Sjöstrand, N. Skinner, J. Slater, T. Smart, R.D. Smirnov, N. Smith, P. Smith, T. Smith, J. Snell, L. Snoj, E.R. Solano, V. Solokha, C. Sommariva, K. Soni, M. Sos, J. Sousa, C. Sozzi, T. Spelzini, F. Spineanu, L. Spolladore, D. Spong, C. Srinivasan, G. Staebler, A. Stagni, I. Stamatelatos, M.F. Stamp, Ž. Štancar, P.A. Staniec, G. Stankūnas, M. Stead, B. Stein-Lubrano, A. Stephen, J. Stephens, P. Stevenson, C. Steventon, M. Stojanov, D.A. St-Onge, P. Strand, S. Strikwerda, C.I. Stuart, S. Sturgeon, H.J. Sun, S. Surendran, W. Suttrop, J. Svensson, J. Svoboda, R. Sweeney, G. Szepesi, M. Szoke, T. Tadić, B. Tal, T. Tala, P. Tamain, K. Tanaka, W. Tang, G. Tardini, M. Tardocchi, D. Taylor, A.S. Teimane, G. Telesca, A. Teplukhina, A. Terra, D. Terranova, N. Terranova, D. Testa, B. Thomas, V.K. Thompson, A. Thorman, A.S. Thrysoe, W. Tierens, R.A. Tinguely, A. Tipton, H. Todd, M. Tomeš, A. Tookey, P. Tsavalas, D. Tskhakaya, L.-P. Turică, A. Turner, I. Turner, M. Turner, M.M. Turner, G. Tvalashvili, A. Tykhyy, S. Tyrrell, A. Uccello, V. Udintsev, A. Vadgama, D.F. Valcarcel, A. Valentini, M. Valisa, M. Vallar, M. Valovic, M. Van Berkel, K.L. van de Plassche, M. van Rossem, D. Van Eester, J. Varela, J. Varje, T. Vasilopoulou, G. Vayakis, M. Vecsei, J. Vega, M. Veis, P. Veis, S. Ventre, M. Veranda, G. Verdoolaege, C. Verona, G. Verona Rinati, E. Veshchev, N. Vianello, E. Viezzer, L. Vignitchouk, R. Vila, R. Villari, F. Villone, P. Vincenzi, A. Vitins, Z. Vizvary, M. Vlad, I. Voldiner, U. Von Toussaint, P. Vondráček, B. Wakeling, M. Walker, R. Walker, M. Walsh, R. Walton, E. Wang, F. Warren, R. Warren, J. Waterhouse, C. Watts, T. Webster, M. Weiland, H. Weisen, M. Weiszflog, N. Wendler, A. West, M. Wheatley, S. Whetham, A. Whitehead, D. Whittaker, A. Widdowson, S. Wiesen, M. Willensdorfer, J. Williams, I. Wilson, T. Wilson, M. Wischmeier, A. Withycombe, D. Witts, A. Wojcik-Gargula, E. Wolfrum, R. Wood, R. Woodley, R. Worrall, I. Wyss, T. Xu, D. Yadykin, Y. Yakovenko, Y. Yang, V. Yanovskiy, R. Yi, I. Young, R. Young, B. Zaar, R.J. Zabolockis, L. Zakharov, P. Zanca, A. Zarins, D. Zarzoso Fernandez, K.-D. Zastrow, Y. Zayachuk, M. Zerbini, W. Zhang, B. Zimmermann, M. Zlobinski, A. Zocco, V.K. Zotta, M. Zuin, W. Zwingmann, and I. Zychor

Subjects
magnetic fusion, JET-ILW, D–T, tritium, alpha particles, fusion prediction, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

In 2021 JET exploited its unique capabilities to operate with T and D–T fuel with an ITER-like Be/W wall (JET-ILW). This second major JET D–T campaign (DTE2), after DTE1 in 1997, represented the culmination of a series of JET enhancements—new fusion diagnostics, new T injection capabilities, refurbishment of the T plant, increased auxiliary heating, in-vessel calibration of 14 MeV neutron yield monitors—as well as significant advances in plasma theory and modelling in the fusion community. DTE2 was complemented by a sequence of isotope physics campaigns encompassing operation in pure tritium at high T-NBI power. Carefully conducted for safe operation with tritium, the new T and D–T experiments used 1 kg of T (vs 100 g in DTE1), yielding the most fusion reactor relevant D–T plasmas to date and expanding our understanding of isotopes and D–T mixture physics. Furthermore, since the JET T and DTE2 campaigns occurred almost 25 years after the last major D–T tokamak experiment, it was also a strategic goal of the European fusion programme to refresh operational experience of a nuclear tokamak to prepare staff for ITER operation. The key physics results of the JET T and DTE2 experiments, carried out within the EUROfusion JET1 work package, are reported in this paper. Progress in the technological exploitation of JET D–T operations, development and validation of nuclear codes, neutronic tools and techniques for ITER operations carried out by EUROfusion (started within the Horizon 2020 Framework Programme and continuing under the Horizon Europe FP) are reported in (Litaudon et al Nucl. Fusion accepted), while JET experience on T and D–T operations is presented in (King et al Nucl. Fusion submitted).

Published
2024
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18. JET machine operations in T&D-T

Author

The JET Operations Team (presented by D.B. King), E. Abdelrahman, A. Abdul Hamid, N. Abid, K. Abraham, O. Adabonyan, C. Adlam, M. Afzal, M. Akhtar, V. Aldred, S. Aldworth, S. Aleiferis, M. Ali, R. Alie, R. Allan, H. Allen, E. Alli, M. Allinson, P. Almond, J. Angus, K. Antcliffe, I. Antoniou, L. Appel, C. Appelbee, C. Aramunde, N. Archer, S. Aria, H. Arkuszynski, M. Arshad, G. Artaserse, A. Ash, C. Ashe, T. Aue, D. Auld, B. Austin, Y. Austin, C. Ayres, R.B. Morales, S. Baker, S. Bakes, I. Balboa, C. Balshaw, N. Balshaw, J. Banks, J. Banner, A. Barnard, M. Barnard, M. Baruzzo, C. Basagiannis, S. Bathe Hariyanandan, P. Batistoni, R. Baughan, P. Beaumont, D. Beckett, A. Begolli, M. Beldishevski, K. Bell, E. Belonohy, J. Bentley, J. Bernardo, M. Berry, J. Bhatt, S. Bickerton, J. Bielecki, W. Bird, D. Blackett, K. Blackman, S. Blake, P. Blatchford, A. Bleasdale, A. Boboc, J. Booth, P. Boulting, M. Bowden, C. Boyd, K. Boyd, R. Bracey, D. Brennan, A. Brett, M. Bright, M. Brix, I. Brooks, B. Brown, P. Brown, M. Brown, P. Brummitt, B. Viola, A. Buckingham, M. Buckley, J. Bumpass, M. Burford, A. Burgess, J. Burton-Sweeten, A. Busse, D. Butcher, P. Cahill, P. Camp, I. Campbell, R. Canavan, J. Cane, M. Cannon, N. Canterbury, A. Carberry, P. Card, M. Carlick, M. Carlo, P. Carman, A. Carruthers, S. Carter, I.S. Carvalho, P. Carvalho, F. Casson, D. Chalk, B. Chamberlain, P. Chauhan, A. Chow, A. Churchman, D. Ciric, M. Clark, J. Clarkson, R. Clarkson, T. Clayton, M. Cleverly, P. Coates, I. Coffey, J. Collins, S. Conroy, N.J. Conway, R. Conway, J. Cook, M. Cooke, D. Coombs, P. Cooper, S. Cooper, G. Corrigan, R. Cotterell, A. Coulson, M. Cox, S. Cox, S. Cramp, D. Craven, R. Craven, M. Crick, D. Croft, T. Cronin, Z. Cui, A. Cullen, R. Cumming, C. Cummings, A. Dal Molin, P. Dalgliesh, S. Dalley, A. Danquah, S. Davies, G. Davis, H. Dawson, K. Dawson, S. Dawson, I. Day, L. de Caires, E. de la Luna, K. Deakin, J. Deane, M. Dearing, A. Dennett, T. Dickson, J. Dobrashian, T. Dochnal, S. Dorling, D. Douai, S. Dowson, J. Drewitt, G. Drummond, P. Dumortier, R. Eade, R. Eastham, K. Eden, J. Edmond, J. Edwards, P. Edwards, H. Elamin, S. Elford, H. El-Haroun, P. Ellis, C. Elsmore, S. Emery, G. Evans, S. Evans, D. Fagan, T. Farmer, I. Farquhar, R. Felton, F. Ferner, J. Fessey, P. Finburg, G. Fishpool, L. Fittill, J. Flanagan, K. Flinders, S. Foley, M. Fontana, M. Fortune, J. Foster, C. Fowler, P. Fox, O. Franklin, R. Franklin, R. Fraser, S. French, M. Furseman, A. Gabbidon, L. Garcia, J. Garcia, M. Gardener, D. Gear, T. Gedling, S. Gee, P. Gell, R. George, S. Gerasimov, M. Gethins, Z. Ghani, L. Giacomelli, C. Gibson, V. Gilsenan, C. Giroud, R. Glen, J. Goff, C. Goodman, A. Goodyear, A. Gordon, S. Gore, S. Gosden, N. Gotts, E. Gow, W. Graham, G. Graham, M. Green, R. Gregory, R. Griffiths, T. Griffiths, F. Griph, C. Grundy, T. Grundy, D. Guard, D. Guest, C. Gurl, S. Hacquin, A. Hakola, K. Hammond, H. Harmer, P. Harper, S. Harris, D. Hart, D. Hattan, A. Haupt, J. Hawes, N. Hawkes, J. Hawkins, P. Hawkins, S. Hayes, S. Hazael, D. Heads, P. Heesterman, O. Hemming, R.B. Henriques, G. Hermon, G. Hewson, T. Hibberd, M. Hill, J. Hillesheim, I. Hirb, K. Ho, C. Hogben, A. Hollingsworth, S. Hollis, M. Hook, D. Hopley, N. Horsten, A. Horton, L.D. Horton, L. Horvath, S. Hotchin, Z. Huang, E. Hubenov, V. Huber, A. Huber, C. Huddart, T. Huddleston, T. Hunter, Y. Husain, A. Hynes, J. Ingleby, S. Ives, E. Ivings, S. Jackson, T. Jackson, P. Jacquet, N. Jayasekera, I. Jepu, D. Jezzard, E. Joffrin, R. Johnson, J. Johnston, C. Jones, E. Jones, G. Jones, L. Jones, S. Jones, T. Jones, M. Jones, A. Joyce, M. Juvonen, A. Kantor, A. Kappatou, G. Karajgikar, J. Karhunen, I. Karnowska-Paterski, E. Karsakos, G. Kaveney, G. Kay, D. Keeling, T. Keenan, R. Kelly, W. Kelly, D. Kennedy, R. Kennedy, O. Kent, K. Khan, D. King, D. Kinna, V. Kiptily, K. Kirov, G. Kneale, M. Knight, P. Knight, J. Knipe, R. Knipe, S. Knipe, P. Kochanski, D. Kos, M. Kovari, E. Kowalska-Strzęciwilk, N. Kraus, M. Kresina, B. Labit, A. Laing, V. Laksharam, N. Lam, B. Lane, C. Lane, T. Lavender, A. Lawson, K. Lawson, G. Learoyd, T. Leeson, X. Lefebvre, J. Lehmann, M. Lennholm, K. Lennon, E. Lerche, S. Lesnoj, E. Letellier, L. Lewin, J. Lewis, J. Li, G. Liddiard, E. Litherland-Smith, F. Liu, R. Lobel, J. Logan, P. Lomas, C. Long, U. Losada, C. Loveridge, T. Lowe, C. Lowry, R. Lucock, G. Lyons, J. Macdonald, P. Macheta, T. Madden, J. Maddock, C.F. Maggi, J. Mailloux, A. Manning, C. Manning, N. Mantel, A. Manzanares, S. Marsden, J. Marsh, R. Marshall, A. Martin, M. Maslov, G. Matthews, N. Mayfield, M. Mayoral, R. McAdams, L. McCafferty, P. McCullen, D. McDonald, A. McDonnell, D. McGuckin, T. McIver, V. McKay, R. McKean, L. McNamee, A. McShee, R. Meadows, D. Mederick, M. Medland, K. Meghani, A. Meigs, S. Menmuir, I. Merrigan, S. Mianowski, P. Middleton, C. Miles, J. Milnes, A. Milocco, J. Mitchell, P. Mitchell, P. Monaghan, I. Monakhov, P. Moody, R. Mooney, C. Moore, N. Mooring, L. Morgan, R. Morgan, J. Morris, O. Morton, S. Morton, P. Mulvana, S. Munot, R. Munro-Smith, K. Musgrave, R. Naish, N. Neethiraj, J. Neilson, A. Newman, S. Ng, M. Nicassio, K. Nicholls, M. Nightingale, C. Noble, R. Normington, C. Nygaard, J. O’Callaghan, R. Olney, B. O’Meara, M. O’Mullane, C. O’Neill, C. Opara, K. O’Rourke, J. Ottley, K. Otu, A. Owen, N. Pace, K. Palamartchouk, D. Paley, J. Palgrave, G. Papadopoulos, V. Parail, A. Parrott, A. Parsloe, L. Parsons, R. Parsons, A. Patel, J. Patel, A. Peacock, M. Pearce, T. Pearce, I. Pearson, J. Penzo, A. Perdas, T. Pereira, C. Perez Von Thun, D. Perry, N. Petrella, M. Peyman, N. Platt, M. Poradzinski, M. Porter, M. Porton, C. Powell, J. Pozzi, M. Price, L. Price, P. Puglia, D. Pulley, K. Purahoo, M. Rainford, A. Raj, S. Randhawa, S. Rapa, K. Ravisankar, C. Rayner, A. Read, C. Reux, S. Reynolds, V. Riccardo, L. Richiusa, D. Rigamonti, F. Rimini, J. Roberts, R. Robins, S. Robinson, T. Robinson, D. Robson, S. Romanelli, F. Rose, C. Rose-Innes, D. Rouse, S. Rowe, N. Rowland, D. Rowlands, M. Rubel, K. Sabin, R. Salmon, H. Salter, A. Sanders, E. Sanders, I. Sanders, D. Sandiford, F. Sanni, R. Sarwar, R. Sayles, C. Scaysbrook, G. Scott, D. Scraggs, S. Scully, R. Sealey, E. Searle, M. Segato, M. Sertoli, C. Shanks, R. Sharma, A. Shaw, K. Sheahan, H. Sheikh, D. Shrestha, R. Siddiqui, S. Silburn, J. Silva, D. Simfukwe, J. Simpson, M. Sinclair, A. Sips, P. Sirén, S. Skeats, N. Skinner, B. Slade, J. Slater, T. Smart, G. Smith, J. Smith, N. Smith, P. Smith, T. Smith, F. P. Smith, J. Snell, K. Snelling, K. Soare, E. Solano, A. Spelzini, C. Srinivasan, Z. Stancar, P.A. Staniec, M. Stead, R. Steadman, L. Steel, D. Steele, A. Stephen, J. Stephens, L. Stevenson, P. Stevenson, C. Steventon, L. Sticklen, M. Stojanov, S. Strikwerda, C. Stuart, G. Stubbs, N. Studd, W. Studholme, H. Sun, S. Surendran, G. Szepesi, M. Szoke, H. Tan, A. Taylor, D. Taylor, K. Taylor, A. Thingore, B. Thomas, J. Thomas, A. Thorman, A. Tilley, A. Tipton, N. Tipton, H. Todd, P. Tonner, A. Tookey, M. Towndrow, M. Tsang, E. Tsitrone, I. Turner, M. Turner, G. Tvalashvili, S. Tyrrell, A. Vadgama, D. Valcarcel, Q. Van Der Westhuizen, J. Verdon, N. Vianello, A. Vittal, Z. Vizvary, B. Wakeling, M. Walker, R. Walker, T. Wall, M. Walsh, T. Walsh, J. Walters, J. Walton, R. Walton, S. Warder, F. Warren, R. Warren, J. Waterhouse, T. Webster, G. Wells, C. Wellstood, A. West, M. Wheatley, S. Whiffin, A. Whitehead, C. Whitehead, D. Whittaker, A. Widdowson, J. Wilcox, D. Wilkins, R. Wilkins, J. Williams, M. Williams, D. Willoughby, A. Wilson, I. Wilson, T. Wilson, M. Wischmeier, P. Wise, G. Withenshaw, A. Withycombe, D. Witts, J. Witts, R. Wood, L. Woodham, C. Woodley, J. Woodley, R. Woodley, B. Woods, S. Wray, T. Xu, I. Young, R. Young, K-D. Zastrow, Y. Zayachuk, and M. Zerbini

Subjects
JET, tritium, operations, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

JET, the world’s largest operating tokamak with unique Be/W wall and tritium handling capability, completed a Deuterium-Tritium (D-T) campaign in 2021 (Maggi et al 29th Fusion Energy Conf. ) following a decade of preparatory experiments, dedicated enhancements, technical rehearsals and training (Horton et al 2016 Fusion Eng. Des. 109–111 925). Operation with tritium raises significant technical, safety and scientific challenges not encountered in standard protium or deuterium operation. This contribution describes the tritium operational requirements, pulses and technical preparations, new operating procedures, lessons learned and details on the achieved operational availability and performance. The preparation and execution of the recent JET tritium experiments benefitted from the previous experience in 1991 (Preliminary Tritium Experiment), 1997 (DTE1 campaign) and 2003 (Trace Tritium Campaigns) and consisted of the following five phases: technical rehearsals and scenario preparation, tritium commissioning, 100% tritium campaign, D-T campaign (DTE2), tritium clean-up. Following the clean-up JET resumed normal operation and is currently undertaking a further D-T campaign (DTE3).

Published
2024
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20. Explaining the Elusive Nature of a Well-Defined Threshold for Blood Transfusion in Advanced Epithelial Ovarian Cancer Cytoreductive Surgery

Author

Alexandros Laios, Evangelos Kalampokis, Marios-Evangelos Mamalis, Amudha Thangavelu, Yong Sheng Tan, Richard Hutson, Sarika Munot, Tim Broadhead, David Nugent, Georgios Theophilou, Robert-Edward Jackson, and Diederick De Jong

Subjects
epithelial ovarian cancer, complete cytoreduction, estimated blood loss, estimated blood volume, blood transfusion, intra-operative mapping, Medicine (General), R5-920
Abstract

There is no well-defined threshold for intra-operative blood transfusion (BT) in advanced epithelial ovarian cancer (EOC) surgery. To address this, we devised a Machine Learning (ML)-driven prediction algorithm aimed at prompting and elucidating a communication alert for BT based on anticipated peri-operative events independent of existing BT policies. We analyzed data from 403 EOC patients who underwent cytoreductive surgery between 2014 and 2019. The estimated blood volume (EBV), calculated using the formula EBV = weight × 80, served for setting a 10% EBV threshold for individual intervention. Based on known estimated blood loss (EBL), we identified two distinct groups. The Receiver operating characteristic (ROC) curves revealed satisfactory results for predicting events above the established threshold (AUC 0.823, 95% CI 0.76–0.88). Operative time (OT) was the most significant factor influencing predictions. Intra-operative blood loss exceeding 10% EBV was associated with OT > 250 min, primary surgery, serous histology, performance status 0, R2 resection and surgical complexity score > 4. Certain sub-procedures including large bowel resection, stoma formation, ileocecal resection/right hemicolectomy, mesenteric resection, bladder and upper abdominal peritonectomy demonstrated clear associations with an elevated interventional risk. Our findings emphasize the importance of obtaining a rough estimate of OT in advance for precise prediction of blood requirements.

Published
2023
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23. Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy

Author

Kim, Hong Joo, Mohassel, Payam, Donkervoort, Sandra, Guo, Lin, O’Donovan, Kevin, Coughlin, Maura, Lornage, Xaviere, Foulds, Nicola, Hammans, Simon R., Foley, A. Reghan, Fare, Charlotte M., Ford, Alice F., Ogasawara, Masashi, Sato, Aki, Iida, Aritoshi, Munot, Pinki, Ambegaonkar, Gautam, Phadke, Rahul, O’Donovan, Dominic G., Buchert, Rebecca, Grimmel, Mona, Töpf, Ana, Zaharieva, Irina T., Brady, Lauren, Hu, Ying, Lloyd, Thomas E., Klein, Andrea, Steinlin, Maja, Kuster, Alice, Mercier, Sandra, Marcorelles, Pascale, Péréon, Yann, Fleurence, Emmanuelle, Manzur, Adnan, Ennis, Sarah, Upstill-Goddard, Rosanna, Bello, Luca, Bertolin, Cinzia, Pegoraro, Elena, Salviati, Leonardo, French, Courtney E., Shatillo, Andriy, Raymond, F. Lucy, Haack, Tobias B., Quijano-Roy, Susana, Böhm, Johann, Nelson, Isabelle, Stojkovic, Tanya, Evangelista, Teresinha, Straub, Volker, Romero, Norma B., Laporte, Jocelyn, Muntoni, Francesco, Nishino, Ichizo, Tarnopolsky, Mark A., Shorter, James, Bönnemann, Carsten G., and Taylor, J. Paul

Published
2022
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26. Genetic insight into Birt–Hogg–Dubé syndrome in Indian patients reveals novel mutations at FLCN

Author

Anindita Ray, Esita Chattopadhyay, Richa Singh, Saurabh Ghosh, Arnab Bera, Mridul Sarma, Mahavir Munot, Unnati Desai, Sujeet Rajan, Pralhad Prabhudesai, Ashish K. Prakash, Sushmita Roy Chowdhury, Niladri Bhowmick, Raja Dhar, Zarir F. Udwadia, Atin Dey, Subhra Mitra, Jyotsna M. Joshi, Arindam Maitra, and Bidyut Roy

Subjects
FLCN mutations, BHDS, Primary spontaneous pneumothorax, Family-based association, Molecular docking, Indian patients, Medicine
Abstract

Abstract Background Birt-Hogg-Dubé syndrome (BHDS) is a rare monogenic condition mostly associated with germline mutations at FLCN. It is characterized by either one or more manifestations of primary spontaneous pneumothorax (PSP), skin fibrofolliculomas and renal carcinoma (chromophobe). Here, we comprehensively studied the mutational background of 31 clinically diagnosed BHDS patients and their 74 asymptomatic related members from 15 Indian families. Results Targeted amplicon next-generation sequencing (NGS) and Sanger sequencing of FLCN in patients and asymptomatic members revealed a total of 76 variants. Among these variants, six different types of pathogenic FLCN mutations were detected in 26 patients and some asymptomatic family members. Two of the variants were novel mutations: an 11-nucleotide deletion (c.1150_1160delGTCCAGTCAGC) and a splice acceptor mutation (c.1301-1G > A). Two variants were Clinvar reported pathogenic mutations: a stop-gain (c.634C > T) and a 4-nucleotide duplication (c.1329_1332dupAGCC). Two known variants were: hotspot deletion (c.1285delC) and a splice donor mutation (c.1300 + 1G > A). FLCN mutations could not be detected in patients and asymptomatic members from 5 families. All these mutations greatly affected the protein stability and FLCN-FNIP2 interaction as observed by molecular docking method. Family-based association study inferred pathogenic FLCN mutations are significantly associated with BHDS. Conclusion Six pathogenic FLCN mutations were detected in patients from 10 families out of 15 families in the cohort. Therefore, genetic screening is necessary to validate the clinical diagnosis. The pathogenic mutations at FLCN affects the protein–protein interaction, which plays key roles in various metabolic pathways. Since, pathogenic mutations could not be detected in exonic regions of FLCN in 5 families, whole genome sequencing is necessary to detect all mutations at FLCN and/or any undescribed gene/s that may also be implicated in BHDS.

Published
2022
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27. Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy

Author

Hong Joo Kim, Payam Mohassel, Sandra Donkervoort, Lin Guo, Kevin O’Donovan, Maura Coughlin, Xaviere Lornage, Nicola Foulds, Simon R. Hammans, A. Reghan Foley, Charlotte M. Fare, Alice F. Ford, Masashi Ogasawara, Aki Sato, Aritoshi Iida, Pinki Munot, Gautam Ambegaonkar, Rahul Phadke, Dominic G. O’Donovan, Rebecca Buchert, Mona Grimmel, Ana Töpf, Irina T. Zaharieva, Lauren Brady, Ying Hu, Thomas E. Lloyd, Andrea Klein, Maja Steinlin, Alice Kuster, Sandra Mercier, Pascale Marcorelles, Yann Péréon, Emmanuelle Fleurence, Adnan Manzur, Sarah Ennis, Rosanna Upstill-Goddard, Luca Bello, Cinzia Bertolin, Elena Pegoraro, Leonardo Salviati, Courtney E. French, Andriy Shatillo, F. Lucy Raymond, Tobias B. Haack, Susana Quijano-Roy, Johann Böhm, Isabelle Nelson, Tanya Stojkovic, Teresinha Evangelista, Volker Straub, Norma B. Romero, Jocelyn Laporte, Francesco Muntoni, Ichizo Nishino, Mark A. Tarnopolsky, James Shorter, Carsten G. Bönnemann, and J. Paul Taylor

Subjects
Science
Abstract

Missense variants in RNA-binding proteins underlie many diseases. Here the authors report an oculopharyngeal muscular dystrophy caused by heterozygous frameshift mutations in HNRNPA2B1 that alter its nucleocytoplasmic transport dynamics and result in cytoplasmic accumulation of hnRNPA2 protein.

Published
2022
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28. Outcomes of patients with hematologic malignancies and COVID-19 from the Hematologic Cancer Registry of India

Author

Arihant Jain, Lingaraj Nayak, Uday Prakash Kulkarni, Nikita Mehra, Uday Yanamandra, Smita Kayal, Sharat Damodar, Joseph M. John, Prashant Mehta, Suvir Singh, Pritesh Munot, Sushil Selvarajan, Venkatraman Radhakrishnan, Deepesh Lad, Rajan Kapoor, Biswajit Dubashi, Ram S. Bharath, Hasmukh Jain, P. K. Jayachandran, Jeyaseelan Lakshmanan, Thenmozhi Mani, Jayashree Thorat, Satyaranjan Das, Omprakash Karunamurthy, Biju George, Manju Sengar, and Pankaj Malhotra

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2022
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32. Cardiac Manifestations of Myotonic Dystrophy in a Pediatric Cohort

Author

Laia Brunet Garcia, Ankita Hajra, Ella Field, Joseph Wacher, Helen Walsh, Gabrielle Norrish, Adnan Manzur, Francesco Muntoni, Pinki Munot, Stephanie Robb, Rosaline Quinlivan, Mariacristina Scoto, Giovanni Baranello, Anna Sarkozy, Luke Starling, Juan Pablo Kaski, and Elena Cervi

Subjects
myotonic dystrophy (DM1), congenital myotonic dystrophy, pediatric population, neuromuscular disorder, cardiac conduction disease, electrocardiographic abnormalities, Pediatrics, RJ1-570
Abstract

Myotonic dystrophy type 1 (DM1) is the most prevalent inherited neuromuscular dystrophy in adults. It is a multisystem disease with cardiac manifestations. Whilst these are well-defined in adults, there are scarce published data in the pediatric population. This study aimed to investigate the yield and progression of cardiac disease in pediatric DM1 patients, focusing on congenital DM1 (cDM1).MethodsA retrospective observational study of all pediatric DM1 patients referred to our center (December 2000-November 2020) was conducted. Patients were classified into DM1 forms according to age of symptom onset and disease severity. Patients underwent clinical and cardiac evaluation with 12-lead ECG, transthoracic echocardiography and 24-h ECG Holter monitoring.Results67 DM1 pediatric patients were included: 56 (83.6%) cDM1 and 11 (16.4%) non-cDM1. Median follow-up time of cDM1 patients was 8.0 [3.25–11.0] years. 49 (87.5%) cDM1 patients had baseline 12-lead ECG and 44 (78.6%) had a follow-up 12-lead-ECG, with a median follow-up time from diagnosis to baseline ECG of 2.8 [1.0–8.5] years and to follow-up ECG of 10.9 [5.7–14.2] years. Overall, 43 (87.8%) presented ECG abnormalities, most commonly in the form of asymptomatic conduction disease (n = 23, 46.9%), of which 21 (42.9%) had first degree atrioventricular block (1st AVB). There was an increase of prevalence from baseline to follow-up ECG in low QRS voltage (16.7%), poor R wave progression (13.9%), abnormal repolarisation (11.9%) and 1st AVB (7.6%). one patient (1.8%) underwent pacemaker implantation for syncope in the context of progressive conduction disease. No patients developed left ventricular systolic dysfunction. 4 (7.1%) cDM1 patients died during follow up, including three who died suddenly with no clear cause of death.ConclusionsThis study is the first to analyse the prevalence and progression of ECG abnormalities in cDM1 pediatric patients. The high prevalence of abnormal findings, progressive changes and number of potentially associated events (1 pacemaker implantation and 3 unexplained sudden deaths) stresses the importance of systematic and continued cardiac evaluation of these patients.

Published
2022
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33. Improving community-based first response to out of hospital cardiac arrest (FirstCPR): protocol for a cluster randomised controlled trial

Author

Sandra Ware, Blake Angell, Julie Redfern, Clara Chow, Cate Ferry, Lee Taylor, Christopher Semsarian, Adrian Bauman, Janet E Bray, Simone Marschner, Michael Nelson, Saurabh Kumar, Matthew Vukasovic, Kevin Lai, Paul M Middleton, Pramesh Kovoor, Garry Jennings, Sonali Munot, Andrew Coggins, Alan Robert Denniss, Sarah Khanlari, and Ian Opperman

Subjects
Medicine
Published
2022
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34. CFD Modeling and Analysis of a Heat-Generating Melt Pool Under External Vessel Cooling and Top Flooding.

Author

Munot, Samyak S., Nayak, Arun K., and Joshi, Jyeshtharaj B.

Abstract

In some nuclear reactors, under accidental conditions, core debris forms a molten pool, which is later located in a core catcher. The core catcher proposed by the authors uses special refractory material to absorb enthalpy of corium so that temperatures are within 1500 K, which is possible to cool with side cooling and top flooding. Since performing a full-scale prototypic experiment is extremely challenging and complex because of the involvement of very high temperatures and the presence of radioactive materials, it is important to develop a Computational Fluid Dynamics (CFD) model capable of simulating coolability of the melt pool with the above cooling strategy. In the present work, a CFD model was developed for the above purpose and was benchmarked with experiments conducted under simulated conditions by the authors. The experiment involved the melting of about 25 L of sodium borosilicate glass at about 1473 K and cooling it in a scaled-down core catcher model. In the presence of decay heat inside the melt pool, turbulent natural convection plays an important role in the temperature distribution inside the melt pool and on the vessel walls. For this, we used different turbulence models. Comparisons among the Standard k-ε, Shear Stress Transport (SST) k-ω, and two-dimensional (2D) Large Eddy Simulation (LES) turbulence models show that SST k-ω and 2D LES turbulences are found to be in good agreement with the experimental results for the temperature distribution in the melt pool, and SST k-ω is found to be computationally less expensive than 2D LES. In general, the CFD model is capable of simulating heat transfer with phase changes inside the heat-generating melt pool. In view of this, the model can be further extended to include cooling of the melt pool in the prototype core catcher. The evolution of crust formation has been investigated in detail using a CFD model. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Out-of-hospital cardiac arrests and bystander response by socioeconomic disadvantage in communities of New South Wales, Australia

Author

Sonali Munot, Emily J. Rugel, Amy Von Huben, Simone Marschner, Julie Redfern, Sandra Ware, and Clara K. Chow

Subjects
Out-of-hospital cardiac arrest, Bystander cardiopulmonary resuscitation, Socioeconomic status, Health equity, Administrative data, Specialties of internal medicine, RC581-951
Abstract

Background & aim: Bystander response to out-of-hospital cardiac arrest (OHCA) may relate to area-level factors, including socioeconomic status (SES). We aimed to examine whether OHCA among individuals in more disadvantaged areas are less likely to receive bystander cardiopulmonary resuscitation (CPR) compared to those in more advantaged areas. Methods: We analysed data on OHCAs in New South Wales, Australia collected prospectively through a statewide, population-based register. We excluded non-medical arrests; arrests witnessed by a paramedic; occurring in a medical centre, nursing home, police station; or airport, and among individuals with a Do-Not-Resuscitate order. Area-level SES for each arrest was defined using the Australian Bureau of Statistics’ Index of Relative Socioeconomic Disadvantage and its relationship to likelihood of receiving bystander CPR was examined using hierarchical logistic regression models. Results: Overall, 39% (6622/16,914) of arrests received bystander CPR (71% of bystander-witnessed). The OHCA burden in disadvantaged areas was higher (age-standardised incidence 76–87/100,000/year in more disadvantaged quintiles 1–4 versus 52 per 100,000/year in most advantaged quintile 5). Bystander CPR rates were lower (38%) in the most disadvantaged quintile and highest (42%) in the most advantaged SES quintile. In adjusted models, younger age, being bystander-witnessed, arresting in a public location, and urban location were all associated with greater likelihood of receiving bystander CPR; however, the association between area-level SES and bystander CPR rate was not significant. Conclusions: There are lower rates of bystander CPR in less advantaged areas, however after accounting for patient and location characteristics, area-level SES was not associated with bystander CPR. Concerted efforts to engage with communities to improve bystander CPR in novel ways could improve OHCA outcomes.

Published
2022
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36. Outcomes of patients with hematologic malignancies and COVID-19 from the Hematologic Cancer Registry of India

Author

Jain, Arihant, Nayak, Lingaraj, Kulkarni, Uday Prakash, Mehra, Nikita, Yanamandra, Uday, Kayal, Smita, Damodar, Sharat, John, Joseph M., Mehta, Prashant, Singh, Suvir, Munot, Pritesh, Selvarajan, Sushil, Radhakrishnan, Venkatraman, Lad, Deepesh, Kapoor, Rajan, Dubashi, Biswajit, Bharath, Ram S., Jain, Hasmukh, Jayachandran, P. K., Lakshmanan, Jeyaseelan, Mani, Thenmozhi, Thorat, Jayashree, Das, Satyaranjan, Karunamurthy, Omprakash, George, Biju, Sengar, Manju, and Malhotra, Pankaj

Published
2022
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37. Ibrutinib: A narrative drug review

Author

Pritesh Naresh Munot, Sumeet Mirgh, Nikita Mehra, and Bhausaheb P Bagal

Subjects
chronic lymphocytic lymphoma, ibrutinib, mantle cell lymphoma, primary central nervous system lymphoma, waldenstrom's macroglobulinemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Ibrutinib is an oral, irreversible covalent inhibitor of the Bruton tyrosine kinase, that plays a major role in B-cell differentiation, proliferation, migration, survival, and apoptosis. It has been found to be active against a number of B-cell malignancies. Ibrutinib has shifted the treatment strategy for malignancies away from cytotoxic chemotherapies toward a more targeted approach. It has already been approved for a number of B-cell malignancies such as mantle cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, Waldenstrom macroglobulinemia, splenic marginal zone lymphoma, and chronic graft-versus-host disease in allogeneic stem cell transplant recipients, and still continues to be evaluated for a number of other B-cell malignancies in various settings. We comprehensively searched the PubMed database to identify and compile the current scenarios in which ibrutinib is indicated for use in oncological practice.

Published
2020
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38. Cancer thrombosis: Narrative review

Author

Pritesh Naresh Munot, Vanita Noronha, Vijay Patil, Amit Joshi, Nandini Menon, and Kumar Prabhash

Subjects
cancer-associated thrombosis, direct oral anticoagulants, low-molecular-weight heparin, vitamin k antagonists, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Venous thromboembolism (VTE) is a common disease in patients with cancer and carries a poor prognosis. Although the exact incidence of VTE in patients with cancer lies between 10% and 40%, it is prevalent in a substantial number of patients, either before starting treatment or during the treatment. Vitamin K antagonists have been traditionally used as the preferred agents for the treatment of VTE. However, multiple studies have revealed that low-molecular-weight heparin (LMWH) is a better alternative for controlling and treating the thrombotic process. Direct oral anticoagulants (DOACs) have aroused considerable interest ever since their introduction. Despite the higher risk of bleeding associated with DOACs, patients prefer taking an oral tablet over parenteral therapy. The data from direct comparative studies are slowly emerging but are currently in favor of LMWH as compared to DOACs. However, in certain scenarios, such as renal failure and thrombocytopenia, other drugs should be considered before prescribing LMWH. Here, we have tried to analyze the current treatment strategy for cancer-associated thrombosis by reviewing articles, studies, and the guidelines based on them. We searched in MEDLINE for articles related to thrombosis and anticoagulation in patients with cancer, published between January 2000 and May 2020, with the full text available in the English language.

Published
2020
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39. Development of an intervention to facilitate dissemination of community-based training to respond to out-of-hospital cardiac arrest: FirstCPR.

Author

Sonali Munot, Janet Bray, Adrian Bauman, Emily J Rugel, Leticia Bezerra Giordan, Simone Marschner, Clara K Chow, and Julie Redfern

Subjects
Medicine, Science
Abstract

Background and aimOut-of-hospital cardiac arrest (OHCA) is a significant public health issue with low survival rates. Prompt bystander action can more than double survival odds. OHCA response training is primarily pursued due to work-related mandates, with few programs targeting communities with lower training levels. The aim of this research was to describe the development process of a targeted multicomponent intervention package designed to enhance confidence and training among laypeople in responding to an OHCA.MethodsAn iterative, three-phase program development process was employed using a mixed methods approach. The initial phase involved establishment of a multidisciplinary panel that informed decisions on key messages, program content, format, and delivery modes. These decisions were based on scientific evidence and guided by behavioural theories. The second phase comprised the development of the intervention package, identifying existing information and developing new material to fill identified gaps. The third phase involved refining and finalising the material via feedback from panel members, stakeholders, and community members.ResultsThrough this approach, we collaboratively developed a comprehensive evidence-based education and training package consisting of a digital intervention supplemented with free access to in-person education and training. The package was designed to teach community members the specific steps in recognising and responding to a cardiac arrest, while addressing commonly known barriers and fears related to bystander response. The tailored program and delivery format addressed the needs of individuals of diverse ages, cultural backgrounds, and varied training needs and preferences.ConclusionThe study highlights the importance of community engagement in intervention development and demonstrates the need of evidence-based and collaborative approaches in creating a comprehensive, localised, relatively low-cost intervention package to improve bystander response to OHCA.

Published
2022
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41. Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study

Author

T Richards, S Shaikh, S Rehman, A Khan, J Shah, C Smith, A Brown, S Singh, A P Arnaud, A Young, D Bowen, P Patel, S Williams, J Dunn, J John, M Loubani, A Hainsworth, A Kolias, PJ Hutchinson, R Singh, S Sinha, S Shaw, J Edwards, S Mukherjee, AAB Jamjoom, A Singh, S Saeed, J Martin, S Smith, S Ross, M Mohan, P Hutchinson, G James, RDC Moon, P Brennan, A Williams, S Brown, A Ward, M Lee, K Thompson, S Ali, J Williams, S Reid, U Khan, J Lambert, A Smith, B Singh, M Hassan, N Sharma, J Reynolds, N Wright, T Williams, H Smith, M Ng, M Rahman, A Taylor, P Shah, D Saxena, J Evans, I Omar, M Ali, A Hanson, Z Li, R Andrade, P Cardoso, H Jeong, P Sharma, M Arrieta, J Clark, L Pearce, J McVeigh, V Sharma, B Kim, J Singh, S Newman, J Byrne, A Hassan, A Persad, A Gardner, H Liu, K Shah, I Hughes, S Davison, A Balakrishnan, K Patel, J Hall, S Mistry, J Parry, R Baumber, N McGrath, E Ross, R Mannion, S Murphy, FL Wright, A Rogers, B Rai, M Thomas, R Ribeiro, E Hamilton, J Teixeira, B Davidson, L Carvalho, R Garrido, A Puppo, A Guimarães, E Santos, M Kamal, M Denning, M Elhadi, J E Fitzgerald, D Miller, M Gowda, C Morris, A Phillips, H Yang, Y Zhang, N Machairas, A Fisher, A Kaufmann, A Aggarwal, L Hansen, M Otify, H Soleymani Majd, A Jones, M Rodrigues, S Sundar, C Jones, R Edmondson, A Sharkey, L Smith, G Williams, J Dunning, E Belcher, D Stavroulias, V Zamvar, M Patel, M Baker, R Evans, M Sherif, J Hopkins, R Mohammed, A Hill, H Jackson, G Jones, K George, J Dixon, A Tong, S Jallad, Deborah S Keller, A Pereira, L Elliott, D Ford, A Sermon, M Almond, Andrew Metcalfe, C Peluso, T White, S Shah, A Witek, Chetan Khatri, A Tiwari, T Lo, K Agarwal, C Sweeney, C Hart, T Holme, S Green, I Ahmed, A Sobti, C Anderson, N Modi, R Campbell, C Magee, M Mirza, D Jones, N Stylianides, X Luo, C Kang, J Ribeiro, L Kumar, J Diaz, A Bhalla, R Young, C Perkins, A James, A Walters, J Reid, R Pereira, C McDonald, A Aujayeb, K Jackson, M Allen, D Ghosh, M Chan, C Price, K Khan, R Moore, M Ibrahim, A Marchbank, M Silva, M Baig, J De Coster, J Castellanos, S Saxena, M Duque, E Li, E Martin, A Isik, J González, RJ Davies, B Smith, R Owen, K Lakhoo, M Rogers, MA Akhtar, K Mellor, S Agrawal, L Foster, G Harris, J McIntyre, M Garner, R West, R Cuthbert, D Johnson, H Gomes, C Roy, N Spencer, D Mehta, J Freedman, J Blair, K Rajput, K Williams, J Wall, A Soliman, F Chen, A Mokhtari, I Mohamed, J Pascoe, M Khalifa, R Das, A Lara, M Costa, A Mahmoud, K Roberts, J Lane, S Robertson, J P Evans, E Krishnan, I Haq, S Rogers, J Knowles, M Chowdhury, A Ghanbari, L Macdonald, S Powell, J Hunt, J Cornish, J Engel, S Page, I Blake, A Rolls, H Ross, D Simpson, J Hammond, A Goyal, K Parkins, A Desai, A Gaunt, A Salim, Y Yousef, A Schache, H Mohan, SR Brown, R Nair, M Flatman, J Lord, RJ Egan, R Harries, N Judkins, K Sugand, T Hine, J Luck, C Johnson, G Salerno, AW Phillips, R Houston, A Volpe, C Walker, C Steele, M Rela, C Barry, R Alves, L Ramsay, A Turnbull, A Daniele, C S Jones, P Gallagher, G Gradinariu, A Oliveira, C Hardie, H Ferguson, S Bhattacharya, E Davies, P Joshi, C Mellor, E Griffiths, A Bhangu, R Mahoney, F Kashora, G Ruiz, K Wong, G Hill, V Testa, S Ford, C Park, P Gomez, C Lopes, A Lázaro, A Shabana, A Agarwal, C Chung, C Politis, G Martin, E Chung, M Ismail, C Cunha, S Correia, I Santos, A Tang, A Robson, T Collier, G Baltazar, M Quintana, C English, M Ip, K Newton, J Kahn, C Tan, D Cheng, R Woods, M Ho, A ABBAS, A Henry, F Rivas, M Mohammed, N Parsons, T Board, S Madan, A Osorio, M Jarvis, M Hashem, A Egglestone, E Halliday, A Ridgway, G Gallo, J Gilliland, W Marx, R Shaw, A Mahmood, K Gohil, B Gallagher, D Alderson, A Karim, G D Stewart, G Peck, L Majkowski, J Carter, H Ishii, L HUMPHREYS, J Khan, S Abbott, C Newton, F Borghi, A Sud, K Bhatia, H Cao, V Vijay, L Sanderson, E Holler, N Hanna, D Ferguson, P Miranda, L Pickering, T Singhal, T Newman, K Ghosh, C Camacho, D Manning, C Lipede, R Clifford, S Higgs, C Menakaya, S Shankar, K Booth, M Abdalla, T Nelson, T Farrell, H Naseem, J Johnstone, A Wilkins, A Brunt, A Nogués, A Patience, D Jeevan, M Vatish, G Stables, S Adegbola, I Hunt, K Dickson, W Matthews, N Dunne, M Maher, G Faulkner, E Hernandez, R Sofat, K Sahnan, A Brunelli, M Raza, K Chui, C Brennan, P Vaughan, H Chu, R Hagger, ASD Liyanage, R Perkins, S Duff, C Gill, H Dean, S Bandyopadhyay, K Ragupathy, Y Cunningham, A Bateman, V Brown, B Ho, E Britton, H Ikram, R Hasan, A Colquhoun, S Handa, A Maqsood, M Caputo, J Torkington, G Fusai, N Hossain, DJ Lin, S Stefan, IR Daniels, D Pournaras, A Askari, P Nisar, S Moug, J Sagar, N Yassin, G Minto, Z Hamady, JR O'Neill, S Chowdhury, R Cresner, D Vimalachandran, FD Mcdermott, RP Jones, P Zerbib, L Sreedharan, S Wahed, SS Gisbertz, MI van Berge Henegouwen, R Preece, I Liew, S McCluney, D Watts, D Nehra, B Dean, D Chaudhry, L Ross, F Solari, S Chatterji, B Barmayehvar, S Lourenco, L Onos, F Mansour, A Radhakrishnan, M Varcada, M Richmond, I Hernández, A Spinelli, H Pham, J Shalhoub, F Wells, K Bevan, A Peckham-Cooper, N Campain, J Steinke, R Wilkin, K McEvoy, S Mastoridis, N Fine, J Bayer, Y Joshi, A Yener, S C McKay, NS Kalson, S Horvath, H Fu, A Parente, SE Lewis, Y Ahmad, G Seidel, M Dunstan, U von Oppell, J Vatish, H Hirsch, K Breen, C Dott, D Mathieu, J Hardie, K Aldridge, A Doorgakant, P Petrone, R Tansey, M El Amrani, C Branco, Y Viswanath, A Meagher, B Keeler, N Tewari, A Gabr, J Kinross, M Longhi, E M Harrison, P Daliya, P Asaad, F Langlands, N Misra, S Kristinsson, S Di Saverio, C Conso, H Roy, E Massie, L Masterson, D Baskaran, A Hannah, O Ismail, S URBAN, J Domenech, S Ranjit, L Massey, S Mannan, D Rutherford, F Colombo, R Kulkarni, D Kearney, Neil J Smart, G Bourke, D Shrestha, P Nankivell, O Breik, R Exley, D Zakai, AK Abou-Foul, P Naredla, R Vidya, G Mundy, H Marin, A E Ward, A Sudarsanam, W Singleton, M Ganau, F Moura, J Blanco, R Myatt, S Sousa, H Zahid, S Garrido, A Fell, E Caruana, D Nepogodiev, F Dhaif, B Bankhad-Kendall, H Kaafarani, C Bretherton, L Marais, K Siaw-Acheampong, B E Dawson, J C Glasbey, R R Gujjuri, E Heritage, S K Kamarajah, J M Keatley, S Lawday, G Pellino, J F F Simoes, I M Trout, M L Venn, R J W Wilkin, A O Ademuyiwa, E Al Ameer, O Alser, K M Augestad, B Bankhead-Kendall, R A Benson, S Chakrabortee, R Blanco-Colino, A Brar, A Minaya Bravo, K A Breen, I Lima Buarque, M F Cunha, G H Davidson, S Farik, M Fiore, G M A Gomes, C Halkias, I Lawani, H Lederhuber, S Leventoglu, M W Loffler, H Mashbari, D Mazingi, D Moszkowicz, J S Ng-Kamstra, S Metallidis, M Niquen, F Ntirenganya, O Outani, F Pata, T D Pinkney, P Pockney, D Radenkovic, A Ramos-De la Medina, A Schnitzbauer, S Shu, K Soreide, S Tabiri, P Townend, G Tsoulfas, G van Ramshorst, Mak JKC, F Tirotta, A Kisiel, LD Cato, AM Pathanki, A Chebaro, K Lecolle, S Truant, FR Pruvot, E Surmei, L Mattei, J Dudek, S El-Hasani, J Cuschieri, GH Davidson, RG Wade, H Elkadi, C Pompili, JR Burke, E Bagouri, Z Abual-Rub, S Munot, M Kowal, SC Winter, F Di Chiara, K Wallwork, A Qureishi, M Lami, S Sravanam, S Chidambaram, R Smillie, AV Shaw, C Cernei, D Jeyaretna, RJ Piper, E Duck, C Jelley, SC Tucker, G Bond-Smith, XL Griffin, GD Tebala, N Neal, TM Noton, H Ghattaura, OBF Risk, H Kharkar, C Verberne, A Senent-Boza, A Sánchez-Arteaga, I Benítez-Linero, F Manresa-Manresa, L Tallón-Aguilar, L Melero-Cortés, MR Fernández-Marín, VM Durán-Muñoz-Cruzado, I Ramallo-Solís, P Beltrán-Miranda, F Pareja-Ciuró, BT Antón-Eguía, AC Dawson, A Drane, F Oliva Mompean, J Gomez-Rosado, J Reguera-Rosal, J Valdes-Hernandez, L Capitan-Morales, del Toro Lopez, A Alanbuki, O Usman, AJ Beamish, D Bosanquet, D Magowan, H Nassa, G Mccabe, D Holroyd, NB Jamieson, NM Mariani, V Nicastro, D Motter, C Jenvey, T Minto, DR Sarma, C Godbole, W Carlos, A Khajuria, H Connolly, G Di Taranto, S Shanbhag, J Skillman, M Sait, H Al-omishy, B Heer, R Lunevicius, ARG Sheel, M Sundhu, AJA Santini, Fathelbab MSAT, KMA Hussein, QM Nunes, K Shahzad, Baig MMAS, JL Hughes, A Kattakayam, SB Shah, AL Clynch, N Georgopoulou, HM Sharples, AA Apampa, IC Nzenwa, D Podolsky, NL Coleman, MP Callahan, P Beak, I Gerogiannis, A Ebrahim, A Alwadiya, C Demetriou, E Grimley, E Theophilidou, E Ogden, FL Malcolm, G Davies-Jones, Ng JCK, N Elmaleh, Z Chia, J A'Court, A Konarski, R Talwar, P S Jambulingam, A Maity, C Hatzantonis, S Kudchadkar, N Cirocchi, CH Chan, H Eberbach, B Erdle, R Sandkamp, G Velmahos, LR Maurer, M El Moheb, A Gaitanidis, L Naar, MA Christensen, C Kapoen, K Langeveld, M El Hechi, B Main, T Maccabe, NS Blencowe, DP Fudulu, D Bhojwani, M Baquedano, F Rapetto, O Flannery, D Tadross, C Blundell, S Forlani, S Guha, CJ Kelty, G Chetty, G Lye, SP Balasubramanian, N Sureshkumar Shah, A Al-mukhtar, E Whitehall, A Giblin, A Adamec, J Konsten, M Van Heinsbergen, A Sou, J Jimeno Fraile, D Morales-Garcia, M Carrillo-Rivas, E Toledo Martínez, Pascual À, A Landaluce-olavarria, M Gonzalez De miguel, Fernández Gómez Cruzado L, E Begoña, D Lecumberri, A Calvo Rey, GM Prada hervella, L Dos Santos Carregal, MI Rodriguez Fernandez, M Freijeiro, S El Drubi Vega, J Van den Eynde, W Oosterlinck, R Van den Eynde, A Boeckxstaens, A Cordonnier, J Jaekers, M Miserez, M Galipienso Eri, JD Garcia Montesino, J Dellonder Frigolé, D Noriego Muñoz, V Lizzi, F Vovola, A Arminio, A Cotoia, AL Sarni, M Bekheit, BS Kamera, M Elhusseini, A Ahmeidat, W Cymes, G Mignot, J Agilinko, A Sgrò, MM Rashid, K Milne, KE Stewart, MSJ Wilson, K McGivern, BC Brown, B Wadham, IA Aneke, J Collis, H Warburton, DM Fountain, R Laurente, KV Sigamoney, M Dasa, Z Naqui, M Galhoum, MT Hasan, R Kalenderov, O Pathmanaban, R Chelva, K Subba, M Khalefa, F Hossain, T Moores, J Anthoney, O Emmerson, R Makin-Taylor, CS Ong, R Callan, O Bloom, G Chauhan, J Kaur, A Burahee, S Bleibleh, N Pigadas, D Snee, S Bhasin, A Crichton, A Habeebullah, AS Bodla, M Mondragon, V Dewan, MC Giuffrida, A Marano, S Palagi, S Di Maria Grimaldi, A Simonato, M D'Agruma, R Chiarpenello, L Pellegrino, F Maione, D Cianflocca, Pruiti Ciarello, G Giraudo, E Gelarda, E Dalmasso, A Abrate, V Ciriello, F Rosato, A Garnero, L Leotta, M Chiozza, G Anania, A Urbani, M Koleva Radica, P Carcoforo, M Portinari, M Sibilla, JE Archer, A Odeh, N Siddaiah, H Carmichael, CG Velopulos, RC McIntyre, TJ Schroeppel, EA Hennessy, L Zier, C Parmar, JM Muñoz Vives, CJ Gómez Díaz, CA Guariglia, C Soto Montesinos, L Sanchon, M Xicola Martínez, N Guàrdia, P Collera, R Diaz Del Gobbo, R Sanchez Jimenez, R Farre Font, R Flores Clotet, CEM Brathwaite, H Hakmi, AH Sohail, R Heckburn, D Townshend, N McLarty, A Shenfine, K Madhvani, M Hampton, AP Hormis, V Miu, K Sheridan, C Luney, MA Williams, A Alqallaf, A Ben-Sassi, R Crichton, J Sonksen, GR Layton, B Karki, S Pankhania, S Asher, A Folorunso, J Winyard, J Mangwani, BHB Babu, C Weerasinghe, M Ballabio, P Bisagni, T Armao, M Madonini, A Gagliano, P Pizzini, A Älgå, M Nordberg, G Sandblom, J El Kafsi, K Logishetty, A Saadya, R Midha, H Subbiah Ponniah, T Stockdale, T Bacarese-Hamilton, N Anjarwalla, D Marujo Henriques, R Hettige, C Baban, A Tenovici, F Anazor, SD King, S Kazzaz, S HKruijff, De Vries JPPM, PJ Steinkamp, PKC Jonker, WY Van der Plas, W Bierman, Y Janssen, ABJ Borgstein, D Enjuto, M Perez Gonzalez, P Díaz Peña, M Marqueta De Salas, P Martinez Pascual, L Rodríguez Gómez, R Garcés García, A Ramos Bonilla, N Herrera-Merino, P Fernández Bernabé, EP Cagigal Ortega, García de Castro Rubio E, I Cervera, MH Siddique, C Barmpagianni, A Basgaran, A Basha, V Okechukwu, A Bartsch, CA Leo, HK Ubhi, N Zafar, H Abdul-Jabar, F Mongelli, M Bernasconi, M Di Giuseppe, D Christoforidis, D La Regina, M Arigoni, A Al-Sukaini, S Mediratta, O Brown, M Boal, S Stanger, H Abdalaziz, J Constable, G Dovell, R Gopi reddy, A Dehal, HB Shah, GWV Cross, P Seyed-Safi, YW Smart, A Kuc, M Al-Yaseen, B Jayasankar, D Balasubramaniam, K Abdelsaid, N Mundkur, RE Soulsby, O Ryska, T Raymond, P Hawkin, G Kinnaman, I Sharma, K Freystaetter, JN Hadfield, A Hilley, S Arkani, M Youssef, I Shaikh, K Seebah, V Kouritas, D Chrastek, G Maryan, DF Gill, F Khatun, J Parakh, V Sarodaya, A Daadipour, KD Bosch, V Bashkirova, LS Dvorkin, VK Kalidindi, A Choudhry, M Espino Segura-Illa, G Sánchez Aniceto, AM Castaño-Leon, L Jimenez-Roldan, J Delgado Fernandez, A Pérez Núñez, A Lagares, D Garcia Perez, M Santas, I Paredes, O Esteban Sinovas, L Moreno-Gomez, E Rubio, V Vega, A Vivas Lopez, M Labalde Martinez, O García Villar, PM Pelaéz Torres, J Garcia Borda, E Ferrero Herrero, C Eiriz Fernandez, C Ojeda-Thies, JM Pardo Garcia, H Wynn Jones, H Divecha, C Whelton, E Powell-Smith, M Alotaibi, A Maashi, A Zowgar, M Alsakkaf, O Izquierdo, D Ventura, D Escobar, U Garcia de cortazar, Villamor Garcia, A Cioci, K Rakoczy, W Pavlis, R Saberi, A Khaleel, A Unnithan, K Memon, RR Pala Bhaskar, F Maqboul, F Kamel, A Al-Samaraee, R Madani, H Llaquet Bayo, N Duchateau, C De Gheldere, A Fayad, ML Wood, G Groot, I Hakami, C Boeker, J Mall, AF Haugstvedt, ML Jönsson, P Caja Vivancos, Villalabeitia Ateca, M Prieto Calvo, P Martin Playa, A Gainza, EJ Aragon Achig, A Rodriguez Fraga, Melchor Corcóstegui, G Mallabiabarrena Ormaechea, JJ Garcia Gutierrez, L Barbier, MA Pesántez Peralta, M Jiménez Jiménez, JA Municio Martín, J Gómez Suárez, G García Operé, LA Pascua Gómez, M Oñate Aguirre, A Fernandez-Colorado, M De la Rosa-Estadella, A Gasulla-Rodriguez, M Serrano-Martin, A Peig-Font, S Junca-Marti, M Juarez-Pomes, S Garrido-Ondono, L Blasco-Torres, M Molina-Corbacho, Y Maldonado-Sotoca, A Gasset-Teixidor, J Blasco-Moreu, V Turrado-Rodriguez, AM Lacy, FB de Lacy, X Morales, A Carreras-Castañer, P Torner, M Jornet-Gibert, M Balaguer-Castro, M Renau-Cerrillo, P Camacho-Carrasco, M Vives-Barquiel, B Campuzano-Bitterling, I Gracia, R Pujol-Muncunill, M Estaire Gómez, D Padilla-Valverde, S Sánchez-García, D Sanchez-Pelaez, E Jimenez Higuera, R Picón Rodríguez, Fernández Camuñas À, C Martínez-Pinedo, EP Garcia Santos, V Muñoz-Atienza, A Moreno Pérez, CA Cano, D Crego-Vita, M Huecas-Martinez, A Roselló Añón, MJ Sangüesa, JC Bernal-Sprekelsen, JC Catalá Bauset, P Renovell Ferrer, C Martínez Pérez, O Gil-Albarova, J Gilabert Estellés, K Aghababyan, R Rivas, J Escartin, JL Blas Laina, B Cros, Talal El-Abur, J Garcia Egea, C Yanez, JH Kauppila, E Sarjanoja, S Tzedakis, PA Bouche, S Gaujoux, D Gossot, A Seguin-Givelet, D Fuks, M Grigoroiu, R Sanchez Salas, X Cathelineau, P Macek, Y Barbé, F Rozet, E Barret, A Mombet, N Cathala, E Brian, F Zadegan, AJ Baldwin, E Gammeri, A Catton, S Marinos Kouris, J Pereca, M Kaushal, A Kler, V Reghuram, S Tezas, V Oktseloglou, F Mosley, MFI De La Cruz Monroy, P Bobak, S Ahad, E Lostis, GK Ambler, J Manara, M Doe, T Jichi, GD Stewart, J Ramzi, AA Singh, J Ashcroft, OJ Baker, P Coughlin, Durst AZED, A Abood, A Habeeb, VE Hudson, B Lamb, L Luke, S Mitrasinovic, Ngu AWT, S Waseem, F Georgiades, XS Tan, J Pushpa-rajah, I Abu-Nayla, S Rooney, E Irune, MHV Byrne, A Durrani, A Sethuraman Venkatesan, T Combellack, G Tahhan, M Kornaszewska, V Valtzoglou, I Deglurkar, M Koutentakis, Syed Nong Chek SAH, M Shinkwin, F Ayeni, H Tustin, M Bordenave, N Manu, N Eardley, OL Serevina, S Roy Mahapatra, K Mohankumar, I Khawaja, A Palepa, T Doulias, Y Premakumar, Y Jauhari, Z Koshnow, A Uberai, F Hirri, BM Stubbs, J Manickavasagam, S Dalgleish, R Kanitkar, CJ Payne, Ng CE, DE Henshall, T Drake, EM Harrison, A Tambyraja, RJE Skipworth, G Linder, R McGregor, J Mayes, R Pasricha, A Razik, S Thrumurthy, D Howden, Z Baxter, L Osagie, M Bence, GE Fowler, N Rajaretnam, A Goubran, JS McGrath, JRA Phillips, DA Raptis, JM Pollok, F Soggiu, S Xyda, C Hidalgo Salinas, H Tzerbinis, T Pissanou, R Mirnezami, N Angamuthu, T Shakir, H Capitelli-McMahon, L Hitchman, A Andronic, A Aboelkassem Ibrahim, J Totty, S Tayeh, T Chase, J Ayorinde, T Cuming, A Trompeter, C Hing, P Tsinaslanidis, MW Benjamin, A Leyte, J Smelt, G Santhirakumaran, A Labib, O Lyons, S Onida, KM Sarraf, S Erridge, S Yalamanchili, A Abuown, D Davenport, S Wheatstone, SM Andreani, MF Bath, A Sahni, L Rigueros Springford, C Sohrabi, J Bacarese-Hamilton, FG Taylor, P Patki, C Tanabalan, ME Alexander, CJ Smart, L Abdeh, M Zeiton, R Advani, S Nikolaou, T Oni, N Ilahi, K Ballantyne, Z Woodward, R Merh, B Robertson-Smith, P Ameerally, JG Finch, C Gnanachandran, I Pop, D Dass, G Thiruchandran, Toh SKC, A Allana, C Bellis, O Babawale, YC Phan, U Lokman, T Koc, L Duggleby, S Shamoon, H Clancy, A Mansuri, A Thakrar, L Wickramarachchi, S Sivayoganathan, E Karam, HV Colvin, A Badran, A Cadersa, A Cumpstey, R Aftab, F Wensley, V Morrison-Jones, GK Sekhon, H Shields, Z Shakoor, T Talbot, A Alzetani, J Rooney, M Rudic, A Aladeojebi, M Kitchen, R Lefroy, P Nanjaiah, AD Rajgor, RJ Scurrah, LJ Watson, T Royle, B Steel, Luk ACO, VG Thiruvasagam, W Marlow, C Konstantinou, D Yershov, A Denning, E Mangos, T Nambirajan, I Flindall, V Mahendran, J De Marchi, NF Davis, A Picciariello, V Papagni, DF Altomare, S Granieri, C Cotsoglou, A Cabeleira, P Serralheiro, T Teles, C Canhoto, J Simões, AC Almeida, O Nogueira, R Athayde Nemésio, MJ Amaral, A Valente da Costa, R Martins, P Guerreiro, A Ruivo, D Breda, JM Oliveira, AL De Oliveira Lopez, M Colino, J De Barros, AP Soares, H Morais, T Revez, MI Manso, JC Domingues, P Henriques, Cardoso N Ribeiro VI, G Martins dos Santos, M Peralta Ferreira, J Ascensão, B Costeira, L Rio Rodrigues, M Sousa Fernandes, P Azevedo, I Lourenço, G Mendinhos, A Nobre Pinto, H Taflin, H Abdou, L O'Meara, Z Cooper, SA Hirji, BU Okafor, V Roxo, CP Raut, JS Jolissaint, DA Mahvi, C Reinke, S Merola, A Ssentongo, P Ssentongo, Oh JS, J Hazelton, J Maines, N Gusani, RCG Martin, N Bhutiani, R Choron, F Soliman, MD E Dauer, E Renza-Stingone, E Gokcen, E Kropf, H Sufrin, J Sewards, J Poggio, K Sanserino, L Rae, M Philp, M Metro, P McNelis, R Petrov, T Pazionis, DB Lumenta, SP Nischwitz, E Richtig, M Pau, P Srekl-Filzmaier, N Eibinger, B Michelitsch, M Fediuk, A Papinutti, TU Cohnert, E Kantor, J Kahiu, S Hosny, A Sultana, M Taggarsi, L Vitone, OP Vaz, I Sarantitis, S Timbrell, A Shugaba, GP Jones, SS Tripathi, MS Greenhalgh, H Emerson, K Vejsbjerg, W McCormick, K Singisetti, Y Aawsaj, R Vanker, M Ghobrial, S Kanthasamy, H Fawi, M Awadallah, J Cheung, S Tingle, F Abbadessa, A Sachdeva, CD Chan, I McPherson, F Mahmoud Ali, S Pandanaboyana, T Grainger, S Nandhra, N Dawe, C McCaffer, J Riches, J Moir, H Elamin Ahmed, C Saleh, RM Koshy, LJ Rogers, PL Labib, N Hope, K Emslie, P Panahi, E Clough, I Enemosah, J Natale, N Raza, JI Webb, M Antar, J Noel, R Nunn, F Eriberto, R Tanna, S Lodhia, C Osório, J Antunes, P Balau, and M Godinho

Subjects
Medicine
Abstract

Objectives Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.Setting Prospective, international, multicentre, observational cohort study.Participants Patients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome 30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.Results This study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).Conclusions Patients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration number NCT04323644

Published
2021
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42. Feature Selection is Critical for 2-Year Prognosis in Advanced Stage High Grade Serous Ovarian Cancer by Using Machine Learning

Author

Alexandros Laios MD, PhD, Angeliki Katsenou PhD, Yong Sheng Tan MBBS, Racheal Johnson MBChB, MRCOG, Mohamed Otify MBBCh, MRCOG, MSc, Angelika Kaufmann MBBS, MRCOG, PhD, Sarika Munot MBBS, Amudha Thangavelu MBChB, MRCOG, MD, Richard Hutson MBBS, MRCOG, MD, Tim Broadhead MBChB, MRCOG, Georgios Theophilou MBBS, MRCOG, MD, David Nugent MBChB, MRCOG, PhD, and Diederick De Jong MBBCh, PhD, MSc

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction Accurate prediction of patient prognosis can be especially useful for the selection of best treatment protocols. Machine Learning can serve this purpose by making predictions based upon generalizable clinical patterns embedded within learning datasets. We designed a study to support the feature selection for the 2-year prognostic period and compared the performance of several Machine Learning prediction algorithms for accurate 2-year prognosis estimation in advanced-stage high grade serous ovarian cancer (HGSOC) patients. Methods The prognosis estimation was formulated as a binary classification problem. Dataset was split into training and test cohorts with repeated random sampling until there was no significant difference (p = 0.20) between the two cohorts. A ten-fold cross-validation was applied. Various state-of-the-art supervised classifiers were used. For feature selection, in addition to the exhaustive search for the best combination of features, we used the-chi square test of independence and the MRMR method. Results Two hundred nine patients were identified. The model's mean prediction accuracy reached 73%. We demonstrated that Support-Vector-Machine and Ensemble Subspace Discriminant algorithms outperformed Logistic Regression in accuracy indices. The probability of achieving a cancer-free state was maximised with a combination of primary cytoreduction, good performance status and maximal surgical effort (AUC 0.63). Standard chemotherapy, performance status, tumour load and residual disease were consistently predictive of the mid-term overall survival (AUC 0.63–0.66). The model recall and precision were greater than 80%. Conclusion Machine Learning appears to be promising for accurate prognosis estimation. Appropriate feature selection is required when building an HGSOC model for 2-year prognosis prediction. We provide evidence as to what combination of prognosticators leads to the largest impact on the HGSOC 2-year prognosis.

Published
2021
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43. Improved Mucoadhesion, Permeation and In Vitro Anticancer Potential of Synthesized Thiolated Acacia and Karaya Gum Combination: A Systematic Study

Author

Neha Munot, Ujjwala Kandekar, Chaitali Rikame, Abhinandan Patil, Poulomi Sengupta, Shabana Urooj, and Anusha Bilal

Subjects
mucoadhesion, thiolated gums, ivabradine HCl, buccal tablets, enhanced permeation, Organic chemistry, QD241-441
Abstract

Thiolation of polymers is one of the most appropriate approaches to impart higher mechanical strength and mucoadhesion. Thiol modification of gum karaya and gum acacia was carried out by esterification with 80% thioglycolic acid. FTIR, DSC and XRD confirmed the completion of thiolation reaction. Anticancer potential of developed thiomer was studied on cervical cancer cell lines (HeLa) and more than 60% of human cervical cell lines (HeLa) were inhibited at concentration of 5 µg/100 µL. Immobilized thiol groups were found to be 0.8511 mmol/g as determined by Ellman’s method. Cytotoxicity studies on L929 fibroblast cell lines indicated thiomers were biocompatible. Bilayered tablets were prepared using Ivabradine hydrochloride as the model drug and synthesized thiolated gums as mucoadhesive polymer. Tablets prepared using thiolated polymers in combination showed more swelling, mucoadhesion and residence time as compared to unmodified gums. Thiol modification controlled the release of the drug for 24 h and enhanced permeation of the drug up to 3 fold through porcine buccal mucosa as compared to tablets with unmodified gums. Thiolated polymer showed increased mucoadhesion and permeation, anticancer potential, controlled release and thus can be utilized as a novel excipient in formulation development.

Published
2022
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44. A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts

Author

Bravo, Laura, Simões, Joana FF, Cardoso, Victor R, Adisa, Adewale, Aguilera, Maria L, Arnaud, Alexis, Biccard, Bruce, Calvache, Jose, Chernbumroong, Saisakul, Elhadi, Muhammed, Ghosh, Dhruv, Gujjuri, Rohan, Harrison, Ewen, Ho, Michael WS, Kasivisvanathan, Veerappan, Kouli, Omar, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Isik, Arda, Marcus, Hani, Martin, Janet, McLean, Kenneth A, Minaya-Bravo, Ana, Modolo, María Marta, Nepogodiev, Dmitri, Pellino, Gianluca, Picciochi, Maria, Pockney, Peter, van Ramshorst, Gabriëlle, Riad, Aya, Sayyed, Raza, Sund, Malin, Gkoutos, Georgios, Bhangu, Aneel A, Glasbey, James C, Bravo, L, Cardoso, V, Glasbey, J, Chernbumroong, S, Nepogodiev, D, Simoes, JFF, Mclean, KA, Bhangu, AA, Gkoutos, G, Kadir, B, Omar, O, Revell, E, Bahrami-Hessari, M, Ahmed, Waheed-Ul-Rahman, Argus, Leah, Ball, Alasdair, Bhangu, Aneel, Bywater, Edward P, Blanco-Colino, Ruth, Brar, Amanpreet, Chaudhry, Daoud, Dawson, Brett E, Duran, Irani, Elhadi, Muhammed, Glasbey, James C, Gujjuri, Rohan R, Jones, Conor S, Harrison, Ewen M, Kamarajah, Sivesh K, Keatley, James M, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder, Marson, Ella J, Mclean, Kenneth A, Nepogodiev, Dmitri, Norman, Lisa, Ots, Riinu, Outani, Oumaima, Picciochi, Maria, Santos, Irène, Shaw, Catherine, Taylor, Elliott H, Trout, Isobel M, Varghese, Chris, Venn, Mary L, Xu, William, Dajti, Irida, Gjata, Arben, Kacimi, Salah Eddine Oussama, Boccalatte, Luis, Modolo, Maria Marta, Cox, Daniel, Pockney, Peter, Aigner, Felix, Kronberger, Irmgard Elisabeth, Samadov, Elgun, Alderazi, Amer, Padmore, Greg, van Ramshorst, Gabrielle, Lawani, Ismaïl, Cerovac, Anis, Delibegovic, Samir, Baiocchi, Glauco, Gomes, Gustavo Mendonça Ataíde, Lima Buarque, Igor, Gohar, Muhammad, Slavchev, Mihail, Nwegbu, Chukwuemeka, Agarwal, Arnav, Brar, Amanpreet, Martin, Janet, Ng-Kamstra, Joshua, Olivos, Maricarmen, Lou, Wenhui, Ren, Dong-Lin, Calvache, Jose Andres, Perez Rivera, Carlos J-, Danic Hadzibegovic, Ana, Kopjar, Tomislav, Mihanovic, Jakov, Avilés Jiménez, Pablo Mijahil, Gouvas, Nikolaos, Klat, Jaroslav, Novysedlák, René, Amisi, Nicolas, Christensen, Peter, El-Hussuna, Alaa, Batista, Sylvia, Lincango-Naranjo, Eddy, Emile, Sameh, Arévalo Sandoval, Danilo Alfonso, Dhufera, Hailu, Hailu, Samuel, Mengesha, Mengistu G, Kauppila, Joonas H, Arnaud, Alexis P, Demetrashvili, Zaza, Albertsmeier, Markus, Lederhuber, Hans, Löffler, Markus W., Kwesi Acquah, Daniel, Ofori, Bernard, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgios, Aguilera-Arevalo, Maria-Lorena, Recinos, Gustavo, Mersich, Tamás, Wettstein, Dániel, Ghosh, Dhruva, Kembuan, Gabriele, Brouki Milan, Peiman, Khosravi, Mohammad Hossein, Mozafari, Masoud, Hilmi, Ahmed, Mohan, Helen, Zmora, Oded, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Fujimoto, Yuki, Kuroda, Naoto, Satoi, Sohei, Abou Chaar, Mohamad K., Ayasra, Faris, Fakhradiyev, Ildar, Hamdun, Intisar Hisham Said, Jin-Young, Jang, Jamal, Mohammad, Karout, Lina, Elhadi, Muhammed, Gulla, 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Bayo, Heura, Colás-Ruiz, Enrique, Bella Romera, Susana, Ruiz Velasquez, Enrique Jose, Núñez, Bernardo, Jimenez, Raul, Zabaleta, Jon, González-Gimeno, Maria Jose, Ortega Vázquez, Irene, Perez Ferrer, Antonio, Martín-Láez, Rubén, Moreno Suarez, Marcelo, Freiria Eiras, Miguel Angel, Ramallo-Solís, Irene, Gomez-Rosado, Juan-Carlos, Oliver Guillen, Jose Ramon, Achalandabaso Boira, Mar, Catalá Bauset, Juan Carlos, Domenech, Julio, Badenes, Rafael, Bernal-Sprekelsen, Juan Carlos, Sancho-Muriel, Jorge, De Andrés-Asenjo, Beatriz, Tejero-Pintor, Francisco J, Vallve-Bernal, Marc, Vazquez Melero, Alba, Sánchez Blasco, Laura, Escartin, Jorge, Duque Mallén, Victoria, Srishankar, Selvaratnam, Jayarajah, Umesh, Sooriyabandara, Charitha, Basnayake, Oshan, Gunawansa, Nalaka, Wickramasinghe, Dakshitha, Weeraddana, Prabuth dulanjan, Vimalakanthan, Thanusan, Gishanthan, Shanthamoorthy, Chandrasinghe, Pramodh, Gialamas, Eleftherios, Sauvain, Marc-Olivier, Ghazal, Ahmad, Al-Sabbagh, Yusra, Alhassoun, Turki, Maa Albared, Sara, Naem, Antoine, Alnahr, Hareth, Jisry, Ghassan, Hammed, Ali, Isik, Arda, Francis Xaviour, Okedi, Turinawe, Gaston, Mubezi, Isaac, Sikakulya, Franck K., Kakeeto, Andrew, Kabweru, Dr. Wilberforce M., Lekuya, Hervé Monka, Kiweewa, Ronald, Lule, Herman, Matovu, Paul, Isaac, Otolia, Mashhour, Mohamed, El Helw, Amin, Alshryda, Sattar, Mohamed, Awadelkarim, Abbas, Ferial Mohamed Ali, Mohammed, Diary, Aldlyami, Ehab, Kundra, Rakesh, Michael, Antony Louis Rex, Alsaadi, Hayder, Khalil, Kareem S., Dbeis, Rachel, Shaikh, Shafaque, Ferry, Jenny, Jamal, Aiman, Siddique, Haleema, Das, Rishi, Ponugoti, Nikhil, Kamarajah, Sivesh K, Rattanasirivilai, Pornjittra, Sultana, Asma, Mosley, Frances, Chan, Matthew, Bateman, Antony, Davies-Jones, Gareth, Georgiades, Fanourios, Stewart, Grant D., Ahmadi, Navid, Coonar, Aman, Baig, Mariam, Khatri, Chetan, Surendran, Arthika, Sonksen, Julian, Sinnerton, Robert, Brennan, Caitlin, Gemma, Greenhalgh, Michael, Emerson, Hannah, Singisetti, Kiran, Totty, Joshua, Wilson, Michael, Lo, Terence, Corbett, Harriet, Okonkwo, Ijeoma, Arbane, Gill, El-Boghdadly, Kariem, Kerawala, Cyrus, Parmar, Chetan, Abbott, Tom, Bath, Michael, Odejinmi, Funlayo, Sagar, Jayesh, Talwar, Rishi, Newman, Samuel, Hammond, John, Moir, John, Duric, Natalie, Szakmany, Tamas, Iftikhar Talib, Ahmar, Youssef, Mina, Lewis-Lloyd, Christopher, Lami, Mariam, Ayub, Khurram, Dean, Benjamin, Balasubramanya, Supriya, Lakpriya, Sathya, Rogers, Luke, Turner, Paul, Maher, Mark, Sigamoney, Kohila, Edwards, John, El Kafsi, Jihène, Hardie, John, Johnson, David, Henein, Christin, Hollyman, Marianne, Agarwal, Ketan, Powell, Simon, Chauhan, Govind Singh, Patel, Rakesh, Gagnier, Joel, Carmichael, Heather, Olson, Kristofor A., Etchill, Eric, Incorvia, Joseph, Hirji, Sameer, Naunheim, Matthew, Drake, Frederick, Kaafarani, Haytham, Reinke, Caroline, Alecci, Anna, Vaysburg, Dennis, Rodriquez, Jennifer, Shih, Emily, Ban, Vin Shen, Coleman, Julia, Rice, Henry E., Kaups, Krista, 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Maximiliano, Zezular, Damaris Idara Anabel, Abuawad, Carla, Albani Forneris, Agustin, Brandariz, Rodrigo, Burchakchi, Arturo, Buttaro, Martin, Cano Busnelli, Virginia, Carminatti, Tomas, Cereghini, Julian, Crespi Amor, María Sol, Figari, Marcelo, Gonzalez Salazar, Esteban, Higuera, Felipe, Llano, Lionel, Lobos, Pablo, Mc Loughlin, Santiago, Mendoza, Efrain, Mercado, Pedro, Moyano, Pablo, Noll, Florencia, Odetto, Diego, Ramos, María Lourdes, Saadi, Jose, Scherñuk, Jordán, Slullitel, Pablo, Taboada, María Victoria, Vagni, Roberto, Montal, Silvina, Alvarez, Fernando Andres, Bruera, Nicolás, Parodi, Matias, Picon molina, Héctor, Belisle, Diego, Esteban, Agustin, García, José Sebastian, Granero, Lucas, Yaryura Montero, José Gabriel, D’Addino, José Luis, Calderón Arancibia, José Alfredo, John, Brooke-Smith, Mark, Hii, Amanda, Kundu, Nikhil, Marshall-Webb, Matthew, McVeay, Christina, Ong, Bee Shan, Parker, Dominic, Barnett, Dylan Richard, Buddingh, Karel, Dobbins, Christopher, Dudi-Venkata, Nagendra, Haque, Izhar-Ul, Herath, Matheesha, Kroon, Hidde M, Lim, Alicia, Moller, Cea-Cea, Neo, Eu Nice, Neo, Eu Ling, Russell, Christine, Tourani, Saam, Tran, Steven, Yin, Yijie, Watson, Matthew, Barker, John, Rugendyke, Anya, Watson, Eleanor, Sercombe, Ashleigh, Tee, Chin Li, Batstone, Martin, Field, Michael, Scott, Benjamin, Stevens, Sean, Charlton, Gabriella, Chen, Si, Gauri, Neha, Hayhurst, Ross, Jang, Seyoung, Zhang, Helen, Latif, Haider, Nagra, Sonal, Rudock, Gareth, Tan, Hannah, Underwood, Kirk, Youssef, Daniel, Bengeri, Savitha, Cheah, Hock Ping, Chen, Paul, Clark, Sara, Dawson, Amanda Caroline, Devan, Eliya, Fitt, Sophia, Gaul, John, Jolly, Danielle, Kane, James Dimitri, Kwok, Kelvin, Laura, Sharon, Lee, Vivian, Liang, Ina, Luo, Haili, Miles, Stephanie, Noor, Anthony, Simpson, Renwick, Cox, Aram, Thani, Nova, Egoroff, Natasha, Farik, Shebani, Moss, Jana-Lee, Wright, Deborah, Salama, Paul, Phan, Du, Townend, David, Chuan, Alwin, Barnett, Stephen, Hasan Kheslat, Hajar, Jamieson-Grigg, Chloe, Larner, Brett, Proud, David, Riddiough, Georgina, Seevanayagam, Sivendran, Zhao, Chris, An, Vinna, Drake, Anna, Hunt, Benjamin, Jain, Anshini, Lim, Christopher Seng Hong, Luck, Tara, Maroske, Georgia, Roubos, Nicholas, Sengupta, Shomik, Tsigaras, Zac, Ward, Salena, Zhou, Jessie, Coates, Amy, Nataraja, Ramesh, Pacilli, Maurizio, Gillard, Andrew, Petrakis, Nikki, Qureshi, Maryum, Seow, Sean Ezekiel, Vivian-Taylor, Josephine, Wheatley, Jennifer, O’Connor, Brendan, Teague, Warwick, Hii, Michael Wei, Isaacs, Anna, Johnson, Mary Ann, Price, Veronique, Rowcroft, Alistair, Shaw, Kalai, Stark, Claire, Lauritz, Brianne, Ong, Chui Foong, Tang, Howard, Davis, Amelia, Peerally, Bibi Nabeeha, Aubin, Anne-Marie, Gourlay, Ralph, Lim, Zhi Ying, Alsoudani, Ali, Amico, Francesco, Anning, Rebecca, Dale, Tyson, Duggal, Anchal, Ennis, Brendan, Fu, Yi Xin Joanna, Gani, Jonathan, Gelzinnis, Scott, Hadlow, Claudia, Hardstaff, Ruth, Lau, Wayne Yan, Liang, Hsin-Ping, Lim, Daniel, Mcilwain, Elysse, Ming, Yan Joyce, Ocsan, Ryan James, Organ, Nicole, Paterson, Amanda, Perez Cerdeira, Marisol, Ting, Caleb, Willoughby, Ellisha, Bailey, Ashley, Narayanan, Viswanathan, Wilkes, Anna, Zhao, Jie, D’Souza, Carl, Forbes, Clara, Haddleton, Monique, Mohammed Abdul, Naseer, Archer, Leigh, Dilevska, Tina, Hans, Tasvinder, Kumar, Mohit, Pham, Terence, Picazo Pineda, Fernando, Suk-Udom, Supisara, Jeyamanoharan, Nivedan, Sala, Michael, Dravid, Madhulika, McCartney, Conor, Sam, Apostolou, Christos, Berney, Christophe, Lam, Andrew, Ma, Vanessa, Cope, Jennifer, Llorando, Alyssa, Mahin, Humaira Haider, Putnis, Soni, Syed, Faisal, Ireland, Patrick, Zhu, Bonnie, Zitt, Matthias, Königsrainer, Ingmar, Allmer, Caterina, Mitteregger, Martin, Seitinger, Gerald, Duller, David, Mathew, Erwin, Skias, Christoph, Brinskelle, Petra, Holzmeister, Clemens, Kahn, Judith, Kresic, Josip, Lindenmann, Joerg, Lumenta, David, Puchwein, Paul, Singer, Georg, Wolf, Axel, Arco, Daniel, Kilic, Nura, Widschwendter, 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Abubakr, Asmaa, Al Gohary, Rawda, Elsabagh, Alaa, Elshabrawy, Enas, Hafez, Ahmed, Mikhail, Pola, Mohamed, Mervat, Nada, Ahmed, Omran, Janna, Salem, Osama, Selim, Salma, Shalaby, Ghada, Wahbah, Mahmoud, Zakaria Abdelbary, Eman, Zayan, Ahmad Helmy, Afify, Abdelrahman, Mohamed Ahmed, Mostafa, Abdeldayem, Hesham, Abdelkader Salama, Ibrahim, Ammar, Khaled, Ayoub, Islam, Gad, Emad Hamdy, Hammad, Essam, Macshut, Mahmoud, Sherif, Ahmed Elshawadfy, Shoreem, Hany, Soliman, Hossam Eldeen, Eldaly, Abdullah, Mashaly, Sarah, Abd-Elsalam, Sherief, Abdel-Elsalam, Wafaa, Morsy, Mohamed Sherif, Nasreddin, Mohammed, Sarsik, Sameh, Kams, Liisa, Rätsep, Tõnu, Riips, Karolin, Abebe, Kirubel, Asfaw, Fitsum, Eshete, Mahder, Gedefaw, Yetsedaw, Menjeta, Abeje, Muleta, Mahteme Bekele, Sefera, Sena, Teklu, Daniel, Tirfe, Leake, Worku, Bereket, Eado, Yegeremu, Negussie, Abraham, Woldemariam, Mersha Abebe, Alemu, Megersa, Azmach, Dawit, Mamo, Dr.Mickyas, Menkir, Abel, Woldemariam, Dereje, Wubishet, Estifanos, Supha, Melka, Abebe, Nebyou, Chanie, Abera, Gebre, Hiwot, Laeke, Tsegazeab, Mammo, Tihitena Negussie, Sahlu, Abat, Tiruneh, Abraham Genetu, Zewdneh, Betelhem, Fentaw, Jibril, Tabore, Ketema, Addisalem, Abreha, Tassew, Abdissa, Desalegn, Tesfaw, Mequannet, Asmamaw, Dawit, Bedane, Dereje, Bekele, Ephrem, Getie, Aderaw, Girma, Adissu, Shimelash, Dagim, Ayalew, Tewabe, Kassahun, Berhanu, Mulugeta, Esubalew, Sisay, Silamlak, Ibrahim, Adem, Mekete, Alem, Mohammed, Adnan Abdulkadir, Abdullahi, Yasir Younis, Adem, Ephrem, Siyoum, Eneyew Getachew, Zeleke, Ewunetu, Degefe, Derje Worku, Derilo, Habtamu, Eliyas, Nebiyu, Deressa, Yadani, Melese, Lemi, Muleta, Lemesa, Teshome, Abraham, Tesso, Birhanu, Gebrekirstos, Dr.Gebreagziabher, Pitkänen, Joel, Qian, Cheng, Sinikumpu, Jaakko, Dakpé, Stéphanie, Devauchelle, Bernard, Lavagen, Nolwenn, Bastard, François, Bin, Kim, Moukoko, Didier, Alshawared, Fadi, Beyrne, Carlos Daniel, Lugans, Laurene, Doussot, Alexandre, Onorati, Ilaria, Radu, Dana, André, Benoît, Marion, Herjean, Trilling, Bertrand, Boleslawski, Emmanuel, Noiret, Barbara, Aubry, Estelle, Subayi Nkembi, Armande, Christou, Niki, Usseglio, Julie, Jeandel, Clement, Denis, Waast, Duchalais, Emilie, Regenet, Nicolas, Rigaud, Jerome, Anract, Philippe, Dohan, Anthony, Cazelles, Antoine, Chamouni, Alexandre, Karoui, Mehdi, Mejean, Arnaud, Crétolle, Célia, Thouement, Clermidi, Pauline, Hervieux, Erik, Langlais, Tristan, Leonelli, Lorenzo, Thomin, Anne, Athiel, Yoann, Cathala, Nathalie, Levy-Zauberman, Yael, Macek, Petr, Mombet, Annick, Ollat, Didier, Fabrice, Chartier-Kastler, Emmanuel, Chereau, Nathalie, Melot, Charlotte, Turco, Célia, Chouillard, Elie, Boisson, Matthieu, Frasca, Denis, Livin, Marie, Mahmoud, Fedy, Sulpice, Laurent, Arnaud, Alexis P, Cazemajou, Clément Thierry, Nyangoh Timoh, Krystel, Renault, Annaëlle, Nappi, Francesco, Ezanno, Anne-Cecile, Cherkaoui, Zineb, Vix, Michel, Gornes, Hugo, Berthoumieu, Pierre, Misrai, Vincent, Pierre, Trocard, Angeles, Martina Aida, Del, Mathilde, Vancon, Antoine, Machemedze, Solomon, Muhemi, Roger, Ndizeye, Olivier, O’Connor, Jennifer, Tchoba, Simplice, Modabber, Ali, Schäfer, Benedikt, Wallqvist, Julia, Ziemann, Sebastian, Anthuber, Matthias, Broecheler, Tobias, Goßlau, Yvonne, Maksymiw, Florian, Sommer, Florian, Sommer, Björn, Loch, Florian N, Aghalarov, Ilgar, Braumann, Chris, Höhn, Philipp, Horn, Julian, Egger, Eva, Enderes, Jana, Strieth, Sebastian, Treede, Hendrik, Wittmann, Maria, Marche, Benedikt, Schulz, Sissy-Amelie, Fuchs, Hans, Bork, Ulrich, Meisel, Cornelia, Petzold, Andrea, Fluegen, Georg, Knoefel, Wolfram Trudo, Solodarenko, Oleksandra, Grützmann, Robert, Hackner, Danilo, Faqar-Uz-Zaman, Sara Fatima, Schnitzbauer, Andreas, Fung, Christian, Leiber, Christian, Neidert, Nicolas, Sandkamp, Richard, Schlager, Daniel, Strähle, Jakob, Spelsberg, Fritz, Becker, Johannes, Gonschor, Bernhard, Herbolzheimer, Marit, Keppler, Lena, Hecker, Matthias, Reichert, Martin, Sander, Michael, Schmidt, Götz, Schneck, Emmanuel, Kleeff, Jorg, Lorenz, Kerstin, Ronellenfitsch, Ulrich, Thomssen, Christoph, Dumpies, Christian W., Fischer, Isabel, Gessner, Michael, Klauke, Friederike, Schmidt, Birte, Vinz, Franziska, Sander, Johannes, Betz, Christian Stephan, Bewarder, Julian, Burg, Simon, Klatte, Till Orla, König, Daniela, Köpke, Leon-Gordian, Stangenberg, Martin, Roux, Frederic, Hakami, Ibrahim Abdullah, Mall, Julian W, Graeb, Christian, Huber-Strößner, Kristin, Pempe, Christina, Kelly, Kathrin, Siebert, Julia, Agrawal, Rachit, Gousias, Konstantinos, Qureischie, Homeira, Meyer, Frank, Rissmann, Anke, Turial, Salmai, Al-Nawas, Bilal, Battista, Marco Johannes, Heider, Julia, Mueller, Lena Katharina, Jentschura, Sina- Louisa Patrizia, Kowalewski, Karl-Friedrich, Rassweiler-Seyfried, Marie-Claire, Reissfelder, Christoph, Rotter, Nicole, Scherl, Claudia, Seyfried, Steffen, Fichter, Andreas, Gempt, Jens, Schäffer, Christoph, Wegmann, Helmut, Aghamaliyev, Ughur, Böcker, Wolfgang, von Ehrlich-Treuenstätt, Viktor H., Ladurner, Roland, Schlager, Justin Gabriel, Smolka, Wenko, Glowalla, Claudio, Schneidmueller, Dorien, Henkel, Karl Wilhelm, Stadler, Josef, Hölz, Katharina, Brunner, Stefan M., Prantl, Lukas, Herzberg, Jonas, Kröger, Marie, Niemeier, Andreas, Sras, Yara, Reinhard, Tobias, Löffler, Markus W., Steidle, Christoph, Dayan, Davut, Greve, Jens, Löbig, Niklas, Schochter, Fabienne, Wezel, Felix, Pusch von, Silke, Schmidbauer, Stefan, Boenicke, Lars, Degener, Stephan, Seiberth, Rose, Smit, Marieke, von Rundstedt, Friedrich-Carl, Germer, Christoph-Thomas, Lock, Johan, Lotz, Christopher, Schlesinger, Tobias, Schmid, Benedikt, Treutlein, Agnes, Agyeman-Duah, Nana Kwaku, Appiah, Enoch, Gakpetor, Delali, Minlah Allah, Stephen, Adu-Aryee, Nii Armah, Agboadoh, Nelson, Bediako Bowan, Antoinette, Brown, George Darko, Clegg-Lamptey, Joe-Nat, Fenu, Benjamin Sena, Kumassah, Philemon, Hussey, Romeo, Agbeno, Evans Kofi, Amoako-Boateng, Mabel, Debrah, Samuel, Doku, Dr Kingsley, Mensah, Philip, Nortey, Michael, Opandoh, Isabella Naa Morkor, Yigah, Makafui, Jiagge, Nuna, Acquaye, Jane, Agyemang-Prempeh, Akosua, Amo-Antwi, Kwabena, Amoah, Michael, Amoah, George, Aning, Daniel Gyawu, Annor Mintah, Dominic, Arthur, Joshua, Darko- Asante, Regina, Gaveh, Valerie, Gyamfi, Frank Enoch, Jonathan, Boakye - Yiadom, Konney, Thomas Okpoti, Kyei, Ishmael, Nimako, Boateng, Ofosu-Barko, Ben Blay, Osabutey, Anita, Sagoe, Robert, Yifieyeh, Abiboye, Ansong, George, Abdul-Mumin, Alhassan, Amadu, Munira, Azahares Leal, German, Buunaaim, Alexis, Cheyuo, Ernest, Daboo Salifu, Latif, Issaka, Adamu, Yakubu, Musah, Grypiotis, Ioannis, Papadopoulou, Triada, Korkolis, Dimitrios, Thomakos, Nikolaos, Dellaportas, Dionysios, Dimitra, Papalouka, Hadjizacharias, Theodoros, Konstadoulakis, Manousos, Massaras, Dimitrios, Vezakis, Antonios, Avgerinos, Konstantinos, Kechagias, Aristotelis, Ioannidis, Argyrios, Patelis, Nikolaos, Deskou, Eirini, Stamos, Nikolaos, Tasis, Nikolaos, Danias, Nikolaos, Selmani, Jonida, Kalamatianos, Theodosis, Stranjalis, George, Kondilis, Panagiotis, Kanellopoulou, Vasiliki, Larentzakis, Andreas, Papanikolaou, Vasileios, Potamianos, Spyridon, Triantafyllou, Tania, Panagiotou, Peter, Avramidis, Emmanouil, Bessias, Nikolaos, Tsiantoula, Paraskevi, Charalabopoulos, Alexandros, Kykalos, Stylianos, Kyros, Eleandros, Machairas, Nikolaos, Mastoraki, Aikaterini, Papalampros, Alexandros, Terras, Alexis, Tsourouflis, Gerasimos, Zografos, Constantinos, Antzaka, Christina, Falara, Areti, Perreas, Konstantinos, Rellia, Panagiota, Tasouli, Androniki, Skolarikos, Andreas, Tzelves, Lazaros, Theodorakis, Emmanuel, Karona, Paraskevi, Tzouganakis, Angelos, Chrysos, Emmanuel, Nikolouzakis, Taxiarchis, Tourountzi, Paraskevi, Al, Aggeliki, Kalfountzos, Christos, Arnaoutoglou, Eleni, Christodoulidis, Gregory, Gkolias, Nick, Hajiioannou, Jiannis, Krestinidis, Giorgos, Ntalouka, Maria, Saini, Fani, Skoulakis, Charalampos, Terzoudis, Christos Dimitrios, Zacharoulis, Dimitris, Δακής, Κωνσταντίνος, Filo, Eva, Kontopoulou, Konstantina, Patoulias, Ioannis, Astreidis, Ioannis, Christidis, Panagiotis, Loutzidou, Lydia, Mantevas, Antonis, Tatsis, Dimitris, Tsakiridis, Ioannis, Iordanidou, Eirini, Brolo, Estuardo, Gutiérrez Ruiz, Alitza, De León Lima, María Alejandra, Flores, Mario-Andrés, Morales, Steffanía, Rivera, Pablo, Rodas, Lesly, Santos, Victor, Sosa, Dianne, Barrios Duarte, Amalia, Talé-Rosales, Luis-Fernando, Villeda, Sergio Alejandro, Anicetti, Joshua, Lowey, Megan, Ardebol, Javier, Barillas, Kathia, Barillas, Sabrina, Recinos, Salvador, Hon, Sophie, Liu, Alex Qinyang, Liu, Shirley, Ip, Ho Wai, Mak, Brian, Mok, Chung Ying, Wong, Kiu Fung, Au-Yeung, Kit Ying, Chan, David Yuen Chung, Chiu, Wang Kei, Ho, Jacky Yan Kit, Kung, Janet Wui Cheung, Ling, Samuel Ka Kin, Lok, Hon Ting, Teoh, Jeremy Yuen-Chun, Wong, Randolph, Antal, Zsuzsanna, Bahrehmand, Kiarash, Sztipits, Tamás, Hidi, László, Piros, Laszlo, Rózsa, Balazs, Herczeg, György, Saftics, György, Kulcsicka-Gut, Judit, Sipos, Zsófia, Majmudar, Hardil, Madabhavi, Irappa, G S, Anitha, Kesarla, Venkatesh, Kumar Venkatappa, Sunil, P B, Hareesh, Shivashankar Chikkanayakanahalli, Santhosh, Sunil, Tanvi, Rajagopal, Niranjana, P L, Thirumanikandan, Mishra, Nitu, Wadhwani, Dr Rekha, Dhurwe, Ritika, Pushpalatha, Kameshwarachari, Raj, Sumit, Singh, Pooja, Kumar, Pankaj, Mittal, Yash, Panigrahi, Sibasish, Parija, Sucheta, Patra, Saroj, Sahu, Rabi, Sultania, Mahesh, Tripathy, Sujit, Kansay, Rajeev, Gupta, Sunil Kumar, Kaman, Lileswar, Salunke, Pravin, Singh, Kavindra, Rela, Mohamed, Goudar, Swati, B, Barani kumar P, Murugesan, Anandan, Subbian, Anbukkani, Kumar, Arvind, Chauhan, Tapan singh, Govil, Akhil, Gupta, Shubhra, Sharma, Ashish, Tiwari, Saurabh, Vishwani, Vartika, Evelyn. R, Nissi, Deb, Mainak, Jayaram, Harish, Nagpal, Pooja, Pathak, Prachi, Choudhary, Gautam Ram, Chugh, Ankita, Elhence, Abhay, Madduri, Vijay, Pandey, Himanshu, Saxena, Rahul, Sharma, Naveen, Shekhar, Shashank, Vishnoi, Jeewan Ram, Bhende, Vishal, Chatterjee, Debarshi, Ghosh, Indranil, Naskar, Upasana, Jain, Prateek, Jain, Deepak, Kewlani, Vishal, Priya, Noopur, Parijat, Anand, Anand, Akshay, Bajaj, Ankur, Chaurasia, Akhilanand, Enny, Loreno E., Kumar, Ambrish, Mishra, Brijesh, Pandey, Amita, Rajan, Shiv, Roy, Ashutosh, Sachan, Rekha, Sankhwar, Pushp, Singh, Uma, Singh, Urmila, Srivastava, Chhitij, Verma, Manju Lata, Yadav, Awdhesh, Agarwal, Gaurav, Chanthar, K.m.m.vishvak, Hoysal, Dileep, Mishra, Anjali, Batra, Nitin, Bhatti, Arun, Dhar, Tapasya, Dutta, Rohini, Haque, Parvez David, Jain, Ritu, Luther, Anil, Mahajan, Amit, Pargal, Dr Pinki, Samuel, Abhishek, Singh, Inderjot, Singh Grewal, Sarvpreet, Singhania, Anusha, Alexander, Philip, Thomas, Josy, Krishna, Sunil, Singh, Narinder, Agarwal, Sunny, Balasubramaniam, Srikant, Dharap, Satish, Mhamane, Rameshwar, Nirgude, Anand, Parab, Sandesh, Peswani, Amit, Sahu, Anjana, Samel, Sarika, Shah, Fagun, Abraham, Bejoy, Asari, Ashishkumar, Badhe, Vivek, Badhwar, Sanjiv, Bothara, Vipul, Dalal, Anuj, Date, Avinash, Deshpande, Mandar, Doshi, Anirudha, Gade, Maya, Gajjar, Shreyash, Ghugare, Dr bhavisha, Jain, Divakar, Jenasamant, Saumya Sekhar, Joshi, Vinay, Kalwadia, Neha, Kayal, Akshat, Kulkarni, Yogesh, Mistry, Rajesh, Mulchandani, Manoj, Parab, Dr. Mrunal, Pednekar, Abhinav, Rahmani, Faizan, Rajput, Sunil, Sandlas, Gursev, Sarkar, Hrishikesh, Shetty, Sanket sadanand, Shukla kulkarni, Anshumala, Thete, Raghavendraswami, Wasnik, Shruti, Dhumane, Parag, Sharma, Rahul Deo, Deshmukh, Anuja, Gupta, Stuti, Nayak, Prakash, Thiagarajan, Shivakumar, Tiwari, Virendra Kumar, Voppuru, Saiesh Reddy, Soni, Rajesh, Bajpai, Minu, Farooque, Kamran, Parshad, Rajinder, Sharma, Vijay, Bansal, Kuldeep, Bains, Lovenish, Bhardwaj, Rohit, Mittal, Abhishek, Ponnusamy, Sabarirajan, Ghodke, Rahul, Himani, Kumar, Ashwani, Gadekar, Anup, Panjwani, Taufiq, Maji, Suvendu, Basu, Somprakas, Kandwal, Pankaj, Kumar, Shashank, Poonia, Dharma Ram, Sadhasivam, Saravanan, Mahakalkar, Chandrashekhar, Choudhury, Yousuf, Das, Devishmita, Goala, Subhadra, Singha, S Thoibisana, Singha, Damayanti, Mehraj, Asif, Parray, Fazl, Shah, Raahil, Wani, Rauf, Hegde, Siddhi, Ankadavar, Dr.sushil, Bafna, Darshan, Lad, Parag, Chisthi, Meer, Jothi, Harihara, .C. Mathew, Godwin David, Abel, Livingston, Barla, Ravi Kishore, Benjamin, Santosh, Bliss, Jeremy, Ete, Geley, James, Deeptiman, Jesudason, Mark Ranjan, Karnan, Gomathi, Mark Samuel, Vasanth, Mittal, Rohin, Nathan, Senthil K, Selvaraj, Daniel, Surendran, Suraj, T D, Hariharan, Thangaraj, Santhosh Kumar, Thomas, Varghese, Dilmy, Mohammad Adya Firmansha, Pratama, Dedy, Sugiarto, Adhrie, Surya, Ilham Utama, Tango, Tamara, Hasyim, Andi, Susanti, Ade, Saputra, Teddy, Syarifuddin, Erwin, Islam, Andi Asadul, Anam, Khoirul, Sugianto, Julius Albert, Lestari, Mayang Indah, Amba, Erick Gamaliel, Apriawan, Tedy, Wathoni, Roidah Taqiyya Zahra, Widyastuti, Yunita, Yun Jufan, Akhmad, Etezadpour, Mohammad, Mehrad-Majd, Hassan, Rajaei, Parisa, Mehdizadeh, Mohammad, Soltani, Mina, Pour, Ali Moazami, Azarnia, Gholamreza, Alizadeh, Narges, Mokarami, Hossein, Tehrani, Shahrzad, Alborzi, Majid, Bagheri, Hamed, Eshraghi, Mohsen, Fatemi manesh, Hassan, Hejazi, Seyed fakhreddin, Pezeshki Modarres, Mahdi, Shafiee, Ali, Vafaeimanesh, Jamshid, Hosseini, Elahe, Nikoupour, Hamed, Bastaninejad, Shahin, Firouzifar, Mohammadreza, Motasaddi zarandy, Masoud, Yazdani, Nasrin, Yousefzadeh Kandevani, Naser, Mortazavi, SM Javad, Ahmadi, Sayedali, Khosravi, Mohammad Hossein, Vosoughi, Fardis, Golbakhsh, Mohammadreza, Al-Isawi, Ali, Al-Masood, Mohammed, Gahtan, Yarub, Ahmed, Abdullah, Hilmi, Ahmed, Muhssein, Haidar, McNestry, Catherine, Ekwere, Bosom, Essajee, Murtaza, Chan Chin, Bruno, Edwards Murphy, Amy, Fleming, Christina, Foley, Niamh, Gardiner, Padraig, Hechtl, Daniel, Kayyal, Mohd yasser, Lyons, Maria, O’Brien, Stephen, Ng, Mei Yee, Oduola, Oladayo, Aljohmani, Lylas, Nugent, Timothy, Harris, Johnathon, Kearney, David, Keenan, Robert Anthony, Nolan, Deirdre, Salloum, Croghan, Stefanie M, Donohoe, Emma, Larkin, John, Lynch, Thomas Hugh, Manecksha, Rustom, Nagassima, Katharina, Barry, Mary, Cullinane, Carolyn, Dowdall, Joseph, Hurson, Conor, Kelly, Orlaith, Kennelly, Rory, Kiernan, Aoife, Murphy, Ben, Njeze, Nwabundo, Reynolds, Ian Sean, Winter, Des, Ravi, Akshaya, Ridgway, Paul, Fowler, Amy, McAnena, Peter, Bahadoor, Muhammad Usaama, Kabir, Syed Mohammad Umar, Khalid, Mohamed Hamed, Mujtaba, Syed Nadeem, Sarwar, Muhammad assam, Sugrue, Michael, Varzgalis, Manvydas, Jones-Whiting, Larne, Lim, Seantee, Ryan, Éanna, Sara, Al-Mukhaizeem, Youssef, Crowley, Clare, Flanagan, Michael, Fogarty, Amy, Glynn, Orna, Hill, Rhodri, Khalid, Muhammad Abdullah, Majeed, Zubair, McCullough, Peter, Neary, Peter, Noone, Anthony, O’Kelly, John, Abu abed, Arsan, Haim, Nadav, Hershkovitz, Yehuda, Majadla, Omar, Rabin, Igor, Zmora, Osnat, Demma, Yonatan Avraham, Fishman, Yuri, Farkas, Amicur, Gozal, Yaacov, Greenman, Dmitry, Ostrovsky, Israel Alexander, Pardes, Rivka, Shahar, Tal, Teren, David, Yahud, Reuven, Yellinek, Shlomo, Cianci, Pasquale, Minafra, Marina, Restini, Enrico, Bussolin, Edoardo, De Prizio, Marco, Sulce, Rezart, Poiasina, Elia, Antonacci, Filippo, Arena, Alessandro, Belvedere, Angela, Bernagozzi, Fabio, Boussedra, Safia, Cescon, Matteo, Cipolli, Alessandro, Daddi, Niccolo’, De Crescenzo, Eugenia, De Iaco, Pierandrea, Del Gaudio, Massimo, Della Gatta, Anna Nunzia, Droghetti, Matteo, Giorgini, Federico A., Lanci Lanci, Antonio, Masetti, Michele, Minni, Francesco, Morezzi, Daniele, Perrone, Anna Myriam, Pignatti, Marco, Puglisi, Silvana Bernadetta, Rottoli, Matteo, Schiavina, Riccardo, Serenari, Matteo, Serra, Margherita, Tesei, Marco, Violante, Tommaso, Aspide, Raffaele, Carretta, Alessandro, Conti, Alfredo, De Vita, Carla, Friso, Filippo, La Corte, Emanuele, Rosetti, Vittoria, Sturiale, Carmelo, Donati, Davide Maria, Palmerini, Emanuela, Berselli, Bruno, Bolognesi, Silvia, Farnia, Francesco, Maremonti, Pietro, Razzaboni, Alessandra, La Mendola, Roberta, Arrigoni, Giulia, Baiocchi, Gian Luca, Molfino, Sarah, Panciani, Pier Paolo, Sartori, Enrico, Zanin, Luca, Perrone, Fabrizio, Cappellani, Alessandro, Giaquinta, Alessia, Gioco, Rossella, Veroux, Pierfrancesco, Cianci, Antonio, Lo Giudice, Arturo, Russo, Giorgio Ivan, Sarpietro, Giuseppe, Scandura, Carmen Emanuela, Barca, Ida, Carnevali, Adriano, De Paola, Gilda, Giannaccare, Giuseppe, Sammarco, Giuseppe, D’Andrea, Marcello, Tosatto, Luigino, Mucilli, Felice, Muraglia, Angelo, Giuliani, Domenico Benvenuto, Segalini, Edoardo, Daniele, Alberto, Gelarda, Enrico, Olearo, Elena, Puppo, Andrea, Testa, Valentina, Porta, Andrea, Birindelli, Arianna, Bernabei, Massimiliano, Feo, Carlo V., Virgilio, Edoardo, Bartolini, Ilenia, Bottari, Andrea, Checcucci, Carlotta, De Vincenti, Rosita, Fambrini, Massimiliano, Fortuna, Laura, Gallo, Oreste, Maltinti, Gherardo, Taddei, Antonio, Michelagnoli, Stefano, Maccagnano, Giuseppe, Pesce, Vito, Ercolani, Giorgio, Fappiano, Francesca, Barberis, Andrea, Filauro, Marco, Santoliquido, Matteo, Aprile, Alessandra, Barra, Fabio, De Rosa, Raffaele, Ferrero, Simone, Sparavigna, Marco, Vagge, Aldo, Gambardella, Denise, Tedesco, Manfredo, Spampinato, Marcello Giuseppe, Chiarelli, Marco, Grandi, Samuele, Lenzi, Riccardo, Muscatello, Luca, Germano’, Antonino Francesco, Giani, Alessandro, Bissacco, Daniele, Cassinotti, Elisa, Pignataro, Lorenzo, Torretta, Sara, Armellin, Daniele, Basato, Silvia, Carrano, Francesco Maria, Colombo, Giovanni, De Lucia, Francesca, De Virgilio, Armando, Ferreli, Fabio, La Raja, Carlotta, Milana, Flavio, Rossi, Vanessa, Russo, Elena, Tamburello, Sara, Zerbi, Alessandro, Bona, Davide, Adamoli, Laura, Ansarin, Mohssen, Chu, Francesco, De Berardinis, Rita, Pietrobon, Giacomo, Sedda, Giulia, Caputo, Maria, Cellerino, Paola, Crespi, Michele Achille, Danelli, Piergiorgio, Ferrara, Francesco, Baccellieri, Domenico, Candiani, Massimo, Casiraghi, Arianna, Cipriani, Federica, De Nardi, Paola, Mortini, Pietro, Nocera, Gianluca, Pozzoni, Mirko, Ruffolo, Alessandro Ferdinando, Spina, Alfio, Barberio, Cristina, Beretta, Luigi, Cavenago, Francesca, Fresilli, Stefano, Landoni, Giovanni, Lombardi, Gaetano, Bonomi, Stefano, Guaglio, Marcello, Sala, Laura, Segattini, Silvia, Piccoli, Micaela, Migliore, Marco, Sasia, Diego, Cereda, Marco, Dell’Oro, Cristina, Fogliati, Alessandro, Tamini, Nicolò, Castaldi, Antonio, Bracale, Umberto, Lionetti, Ruggero, Pagano, Gianluca, Peltrini, Roberto, Pirozzi, Nello, D’amico, Maria, Izzo, Francesco, Marra, Ester, Marte, Gianpaolo, Bianco, Francesco, Cappiello, Antonio, Iovino, Claudio, Menna, Maria Paola, Romano, Francesco maria, Rossi, Settimio, Sciaudone, Guido, Ascari, Francesca, Bellora, Paolo, Cerri, Cristina, D’Aloisio, Giordana, Ferrari, Maurizio, Chioffi, Franco, Ciccarino, Pietro, Nezi, Giulia, Bissolotti, Guido, Di Donna, Mariano Catello, Licari, Leo, Salamone, Giuseppe, Toia, Francesca, Annicchiarico, Alfredo, Berretta, Roberto, Capozzi, Vito Andrea, Freyrie, Antonio, Frusca, Tiziana, Arici, Vittorio, Bozzani, Antonio, Filardo, Matteo, de Manzoni Garberini, Andrea, Cauteruccio, Michele, Caristo, Giuseppe, Calabrò, Marcello, Andreani, Lorenzo, Antonio, D’arienzo, Berrettini, Stefano, Colangeli, Simone, Cremonini, Camilla, Dallan, Iacopo, Di Franco, Gregorio, Korasidis, Stylianos, Musetti, Serena, Neri, Carlo Maria, Palmeri, Matteo, Picariello, Miriana, Statuti, Erica, Tartaglia, Dario, Pinotti, Enrico, Basso, Stefano Maria Massimiliano, Ubiali, Paolo, Coiro, Saverio, Mele, Simone, Corbellini, Carlo, Masciandaro, Antonio, Carannante, Filippo, Denaro, Vincenzo, Mazzotta, Erica, Zampogna, Biagio, Cinquepalmi, Matteo, Del Basso, Celeste, Guglielmo, Nicola, Meniconi, Roberto Luca, Sinibaldi, Giovanni, Agnes, Annamaria, Belia, Francesco, Bianchi, Valentina, Cozza, Valerio, Fico, Valeria, Fransvea, Pietro, La Greca, Antonio, Litta, Francesco, Pascale, Marco Maria, Silvia, Tedesco, Benevolo, Maria, Campo, Flaminia, Dona’, Maria Gabriella, Marchesi, Paolo, Mastroianni, Riccardo, Mazzola, Francesco, Moretto, Silvia, Petruzzi, Gerardo, Pichi, Barbara, Tuderti, Gabriele, Bellato, Vittoria, Grande, Michele, Petagna, Lorenzo, Sensi, Bruno, Bruzzaniti, Placido, Ciccarone, Flavia, Cicerchia, Pierfranco Maria, Cirillo, Bruno, D’ambrosio, Giancarlo, De Toma, Giorgio, Familiari, Pietro, Fonsi, Giovanni Battista, Pata, Francesco, Picchetto, Andrea, Salvati, Maurizio, Valentini, Valentino, Zambon, Martina, Zancana, Giuseppa, Zuppi, Emma, Ibrahim, Mohsen, Menna, Cecilia, Rendina, Erino Angelo, Accarino, Giulio, Giancarlo, Accarino, Froiio, Caterina, Copelli, Chiara, Di Maio, Pasquale, Giudice, Marco, Altana, Cristian, Ciccarello, Sandro, Cossu, Maria Laura, Dessole, Francesco, Dettori, Salvatora, Madonia, Massimo, Petrillo, Marco, Piredda, Franco, Rizzo, Davide, Scognamillo, Fabrizio, Soma, Damiano, Tanca, Anna Rita, Marano, Luigi, Pesce, Anna Lisa, Piccioni, Stefania Angela, Resca, Luca, Roviello, Franco, Abrate, Alberto, Clarizia, Guglielmo, Franzini, Marco, Fratto, Antonio, Grechi, Alessandro, Scarnecchia, Elisa, Maiuri, Vincenzo, Dalprà, Francesca, Battistella, Enrico, Romano, Maurizio, Aizza, Giada, de Manzini, Nicolò, Drigo, Davide, Mastronardi, Manuela, Palmisano, Silvia, Bardelli, Laura, Borroni, Giacomo, Livraghi, Lorenzo, Palumbo, Mara, Zullo, Alessandra, Vignotto, Chiara, Caravati, Andrea, De Cristofaro, Carlotta, Giuliani, Tommaso, Guglielmi, Alfredo, Pedrazzani, Corrado, Butturini, Giovanni, Moretto, Gianluigi, Mastriale, Francesco, Olmi, Stefano, Kushikata, Tetsuya, Oyama, Tasuku, Kamiyama, Mizue, Tarao, Kentaroh, Yamada, Takayuki, Shiga, Toshiya, Deguchi, Yoshihiko, Hoshino, Tatsuki, Inoue, Hiroyuki, Ito, Shingo, Takano, Emi, Yamamoto, Masae, Matsuki, Yuka, Matsumoto, Takashi, Sawada, Atsushi, Sato, Kozo, Makino, Jun, Mizota, Toshiyuki, Yonekura, Hiroshi, Ishikawa, Haruka, Kaiho, Yu, Ogawa, Munehiro, Endo, Shunji, Fujiwara, Yoshinori, Kubota, Hisako, Okada, Toshimasa, Hisamatsu, Yoji, Michiura, Taku, Satoshi, Okazaki, Fujita, Tomoyuki, Fukushima, Satsuki, Otsuka, Yuji, Sawada, Ikumi, Miyamoto, Morikazu, Isada, Tetsuro, Bani Amer, Qaed, Fujimoto, Yuki, Kuratani, Norifumi, Takada, Misa, Noro, Shusaku, Kuroda, Naoto, Okamura, Yukiyasu, Uesaka, Katshuhiko, Kuroda, Kento, Abe, Nobutsugu, Ando, Tadao, Hirano, Kouichi, Kobayashi, Yoichi, Motoyasu, Akira, Noguchi, Hikari, Tajima, Atsushi, Toyama, Satoshi, Uchida, Tokujiro, Furukawa, Yuri, Hasumi, Yoko, Iida, Katsuyuki, Ikeda, Tatsuhiko, Kuzuhara, Shigeki, Yamamoto, Naoya, Yamamoto, Mari, Yokota, Toshiya, Yoshioka, Yuki, Kawai, Akira, Nakata, Yoshinori, Sawamura, Shigehito, Kobayashi, Takayuki, Alqudah, Majdi Ali, Alrabadi, Mera, Owais, Qais, Smadi, Aseel, Abunawas, Huthifa, Alhawatmeh, Mohammad, Alwardat, Abdel Rahman Mohannad Ahmad, Dhoon, Slsabela, Jaradat, Enas, Mubaydeen, Teeba, Alzraikat, Sayel H., Omari, Rand Y., Suradi, Haya H., Al Abdallah, Murad, Al Bdour, Zakaria, Al-thaher, Mohammad, Alnajjar, Tareq, AlZaatreh, Mohammad, Ayasra, Faris, Ghayada, Ibrahim, Hasanein, Khaled Moh’d Ahmed, Hassouneh, Anas, Hijazeen, Raid, Khasawneh, Barihan, Semrin, Qusai, Theab, Mohammad, Abazeed, Alaa, Alkurdieh, Moh’d Mujahed, Hammouri, Mohammad, Khader, Sereen, Abu Obead, Hamza, Abudari, Hadeel, Al-azzeh, Nimer, Al-Darabah, Ali, Al-Qannas, Mohammad, Ashour, Subhi, Chabaan, Reem, Fawzi, Ahmad, Haij, Manal, Hassouneh, Esraa, Ibrahim, Zainab, Mohamed, Ishak, Qandeel, Mahmoud, Qassem, Faisal, Shorman, Marwan, Nofal, Sandra, Salameh, Mohammed, Sanjuq, Ghaidaa, Sharabi, Alaa, Sweiti, Alaa, Baninasr, Eman, Abuleil, Amro, Abou Chaar, Mohamad K., Al-latayfeh, Motasem, Al-Shudifat, Abdel-Ellah, Shaikh Ahmad, Abd Almonem, Abu Abed, Laith, Allouzi, Mohammad, Almi’ani, Sari, Alsaiad, Abdulhakim, Daoud, Maher, Dawod, Omar, Fadli, Saba, Jimaale, Elmi Ahmed Mohamed, Qulaghassi, Zaki, Al-howthi, Mohammed, Ababneh, Laila, Ababneh, Roba, Al Khassawneh, Ahmad, Al Sharie, Ahmed, Al-Dabaa, Tawfik, Al-Jarrah, Salsabeel, Alshannaq, Qutaiba, Alsulaiman, Rima, Audat, Ziad, Bdour, Saja, Khatatbeh, Ro’a, Marji, Fares, Abu Ismail, Dima.Y, Abu-Ismail, Luai, Alzoubi, Mai, Alzoubi, Malak, Hussein, Hasan, Rawashdeh, Shireen, Ababneh, Adnan, Abu-Eisheh, Basil, Al Shurman, Hana’, Al-atiyah, Hussam, Aljaiuossi, Anas, Hamdoni, Sara, Kulimbet, Mukhtar, Sakhov, Orazbek, Fakhradiyev, Ildar, Tanabayeva, Shynar, Zhussupov, Baurzhan, Amrayev, Sultan, Kukubassov, Yerlan, Parker, Robert, Mwaria, Claude, Kibunyi, Muthoni, Mailu, Claire, Osea, Lydia, Hirsi, Omar, Dashti, Mustafa, Aldalal, Shuaib, Alozairi, Ous, Al-Shaiji, Tariq, Alhunaidi, Omar, Aljewaied, Ali, Farag, Ahmed, Termos, Salah, Sivins, Armands, Apse, Ingus Arnolds, Kaminskis, Aleksejs, Pāvulāns, Jānis, Itani, Rania, Owiedat, Mustafa, Antonios, Ingrid, Milan Moussa, Rita, Abdel Sater, Ali H., Souleiman, Bassem, Ghiya, Peter, Fakih, Ghinwa, Tamoos, Khalil, Abdulrahman, Taha, Omar Abunaaja, Hayat, Al Gasi, Abd El Jawad, Al maadany, Faraj, Alsaeiti, Sara, Elkhafeefi, Fatimah, Alhouni, Tarek, Alkeelani, Hana, Alkuwafi, Rauoof, Elbargathe, Osama, Elfadli, Mustafa, Elmahgoub, Asma, Alansari, Arowa hassan abdulrahman, Alhaje, Awatif, Haron, Aaya, Alsuwiyah, Suhir, Khel, Samer, Yousef, Rowaida, Abuhlaiga, Ma’aly, Abushahma, Ahmed omar, Aldelensi Alzubi, Alhosen Saleh M, Alnehum, Mohamed alnaser, Alzedam, Ahmad, Matoug, Faisel, Mohammed, Burooj, Sawalem, Mohamed, Kamoka, Elhusain, Salamah, Abdulrauf, Abdeewi, Saedah, Eshnaf, Mabroka, Yahmad, Mohammad, Aljuroushi, Omar, Attia, Hajer, Emran, Ayyah, Samer, Ashraf, Abdullah, Duha milad, Ben esmael, Esraa, Benmasoud, Fatma, Debri, Laila, Younis, Balkees, Elmabrouk, Amna, Hasan, Ameerah Mahdi Abraheem, Suliaman, Taha, Alawami, Mohammed, Alshareea, Entisar, Aribi, Tomather, Lamari, Amani hamid, Mufth, Mohammed, Aburima, Sarah, Al shukri, Asmaa, Alarabi, Rehab, Alelwany, Aisha, Bashir, Rasha, Elhadi, Ahmed, Elkouba, Esraa, Ellojli, Ibrahim, Elmsherghi, Nabiha, Haidar, Arwa, Helal, Hala, Kriem, Eslam, Turshani, Laila, Alayan, Mohammed, Ben Hasan, Hayat, Shaban Ben Hasan, Najat, Shaban Ben Hasan, Rabab, Dambrauskas, Zilvinas, Dekeryte, Inga, Koženiauskaitė, Akvilė, Maleckas, Almantas, Venclauskas, Linas, Zilinskas, Justas, Syminas, Vilius, Aliosin, Oleg, Cizauskaite, Agne, Jurgaitis, Jonas, Mikutaitis, Vytenis, Samalavicius, Narimantas Evaldas, Slepavicius, Algirdas, Vasiliauskas, Bernardas, Dulskas, Audrius, Cekauskas, Albertas, Gulla, Aiste, Zelvys, Arunas, Noël, Audrey, Rajaonarivony, Maheriandrianina Fanambinana Voahary, Andriantsoa, Herimampionona E, Samison, Luc Hervé, Tsiambanizafy, Guillaume Odilon, Solo, Corinne Eulalie, Safiry Andofenohasina, Fanonjomahasoa, Sablon Herinirina, Angelin, Das, Andre, Osman, Mohd Firdauss, Soh, Jien Yen, Zakaria, Zaidi, Chan, Kheng Hooi, Johan, Syamim, Mah, Jin Jiun, Subramaniam, Sentilnathan, Ibrahim, Mohd Razali, Nazimi, Abd Jabar, Bal, Pavin, Fadzli, Ahmad nazran, Jamaris, Suniza, Lee, Yeong Sing, Lim, Jeffery Zk, Moh Pauzi, Siti Farhan, Nair, Ashvin Krishna, Ng, Doris Sin Wen, Ng We Yong, Yuki Julius, Roslani, April Camilla, Saaid, Rahmah, Sethi, Neha, Syed Jafer Hussain Zaidi, Syeda Nureena, Teoh, Li Ying, Munjih, Islah, Sainal, Mohd Yusof, Sarif, Mat Salleh, Chua, Richelle, Ahmad, Abdul Rauf bin, Lau, Yii Ling, Liew, Ka Yee, Palayan, Kandasami, Abdul Rahman, Noorneza, Firman, Fatin, Hazleigh, Nik Mohd, Mohd Miswan, Mohd Fairudz, Mohd Zahid, Akmal Zulayla, Yahaya, Mohd Yusoff bin Yahaya, Yusoff, Ahmad Ramzi, Darryl, Brincat, Svetlana, Caruana, Clifford, Chircop, Daniel Mario, Czok, Viktoria, Muscat, Esther, Roshan, Mohsin Hassan Khan, Schembri, Nicholas, Jonathan Rubén, Cedillo Rodrìguez, Rojas Aguilar, Antonio, Sosa Duran, Erik Efrain, Arroyo, Diego, Martinez-Said, Hector, Medina-Franco, Heriberto, Pérez de León Vázquez, Martha Patricia, Soto Hernández, Fidel, Stenner, Juan Ignacio, Zuloaga Fernandez del Valle, Carlos Jose, Colunga Tinajero, Carlos Andres, Yanowsky-Reyes, Guillermo, Camacho Gomez, Aldo, Cueva-Martinez, Esteban, Durán Anguiano, Oscar, García Castillo, Miguel, Gonzalez Ojeda, Alejandro, González-García de Rojas, Erick Alonso, Guzman Barba, Jose Aldo, Ibarrola Peña, Juan Carlos, Íñiguez Martínez, César, Llamas- Macias, Francisco Javier, Ambriz Gonzalez, Gabriela, Morales valencia, Eduardo, Santos, Blanca, Torres Cisneros, Juan Roberto, Bozada-Gutiérrez, Katya, Alvarez, Maria Regina, de la Rosa Abaroa, Marco Antonio, Hernandez, Roberto, Bernardo, Anaya, Ernesto, Arceo-Olaiz, Ricardo, Lopez Flores, Sonia, Esparza Arias, Nereida, Romero Bañuelos, Esmeralda, Salcedo-Hernández, Rosa, Buerba, Gabriela Alejandra, Chan, Carlos, Garay Lechuga, Daniel, Hinojosa, Carlos, Mercado, Miguel Ángel, Peña Gómez Portugal, Emmanuel, Posadas-Trujillo, Oscar Emmanuel, Hernandez Skewes, Karla Yareli, Licona-Meníndez, Roque Delfino, Romero Lechuga, Fernanda, Roque, Oscar, Núñez-González, Roberto Ángel, Alvarez Manilla Orendain, Alfonso, Garcia, Felipe, González León, Juan Antonio, Guzman, Marlin, Herappe, Dorihela, Lerma, Ricardo, Mendoza Pedraza, Fabián Hilario, Noguez Castillo, Monica, Resendiz, Jose Anatolio, Fernandez Rios, Laura Elena, Frigerio, Pamela, Garcia, Iset, Mendoza Frías, Gloria Isela, Anzures Mendoza, Alejandra, Hdez Miguelena, Luis, Zarate Saenz, David, Zavala gonzalez, Miguel angel, Andrade González, Francisco, Cortes, Ludivina, Gurghiș, Radu, Sanjaa, Burmaa, Ait benhamou, Rita, Rghioui, Mounir, Saaf, Sarra, Letrache, Ahmed, Zekhnini, Meryem, Abichou, Wijden, Baroudi, Salma, Hassoun, Chiraz, Zaim, Ouijdane, Arkha, Yasser, Bechri, Hajar, Benchekroun Belabbes, Meryem, Benslimane, Zaineb, Boualila, Lina, El Ouahabi, Abdessamad, Essakalli Hossyni, Leila, Tagmouti, Adam, Belkhadir, Zakaria Houssaïn, Benkabbou, Amine, Boutayeb, Saber, El Ahmadi, Brahim, Ghannam, Abdelilah, Kabbaj, Taha, Majbar, Anass Mohammed, Ndayishyigikiye, Marcel Didier, Ndatewapo, Fillipus, Njuki, Peter Ngungi, Abrahams, Jenevive, Bhusal, Subarna, Dwa, Yam, Bloemers, Frank, Besselink, Marc, van Amstel, Paul, Smeele, Ludi, Harlaar, Niels, van der Burg, Sjirk, Noltes, Milou, Steinkamp, Pieter, Franken, Josephine, Oosterling, Steven, Nolte, Peter, Alwayn, Ian, Braat, Andries, Goudsmit, Ben, van de Leemkolk, Fenna E.M., Albers, Kim, Van Goor, Harry, van Ginhoven, Tessa M., Schweitzer, Donald, Leclercq, Wouter, Vancoillie, Peter-Jan, Konsten, Joop, den Boer, Frank, Djamali, Kaveh, Ghamri, Naji, Joseph, Reece, Lie, Samuel, Olliff, Sue, Wood, Daniel, Furkert, Chris, Teague, Rebecca, Lim, Eric, Mclauchlan, Jared, Ailabouni, Ramez, Alqassab, Mohammed, Hawkins, Robyn, Baker, Joseph, Ou, Cindy Xin Yi, Singh, Vidit, Frunt, Brytt, Lakshman, Prashant, Henderson, Nigel, Ha, Jeong, Haimona, Maira, Jury, Steffanie, Weeratunga, George, Witcomb Cahill, Henry, Abdussalam, Hameedat Opeyemi, Ahmed, Aminat Olayinka, Adeyeye, Ademola, Kayode-Nissi, Victor, Kadiri, Innih, Oduah, Stella, Olaogun, Julius, Abdull, Mohammed, Abdullahi, Mohammed Kabir, Ja’afar, Abubakar Bappah, Ja’afaru, Umma Hani, Yakubu Mohammed, Husseini, Edetanlen, Ekaniyere, Iribhogbe, Oseihie, Irowa, Omorodion, Nwashilli, Nnamdi, Obahiagbon, Osarobo, Onyeagwara, Ngozi, Oseghale, Eustace, Osemwegie, Osarenkhoe, Osho, Philip, Akanni, Bolaji, Ezomike, Uchechukwu, Okoro, Kelechukwu, Okwara, Blasius, Abdulsalam, Khalifa, Agida, Eyaofun, Ajibola, Hafees, Benard, Adeka, Buba, Amina, Eniola, Sefiu, Isah, Aliyu, Olute, Anne, Osagie, Olabisi, Pius Ogolekwu, Idoko, Ademola, Samuel, Afuwape, Oludolapo, Daodu, Israel, Egbuchulem, Ifeanyichukwu Kelvin, Lawal, Taiwo Akeem, Nwaorgu, Onyekwere, Obadan, Izegaegbe, Odeyemi, Olubunmi, Ogundoyin, Omowonuola, Okere, Oghenekevwe, Oladiran, Ajibola, Olagunju, Naomi, Olawoye, Olayinka, Olusanya, Adeola, Oyelakin, Oyeleye, Ugwu, Ebere, Ademuyiwa, Adesoji, Atoyebi, Oluwole, Bode, Chris, Chibuike George, Ihediwa, Ezenwankwo, Francis, Fatuga, Adedeji, Ladipo-Ajayi, Oluwaseun, Ojewola, Rufus Wale, Okunowo, Adeyemi, Seyi-Olajide, Justina, Ugwu, Aloy Okechukwu, Adebara, Idowu, Adeyemo, Olabisi, Banjo, Oluseyi, Obateru, John, Ojo, Owolabi, Okunlola, Abiodun, Oluwafemi, Fatudimu, Adelaja, Aderinsola, Atobatele, Kazeem, Ayodele, Olabamidele, Bello, Funmi, Omisanjo, Olufunmilade, Aderounmu, Adewale, Adisa, Adewale, Ajekwu, Temitope, Ajekwu, Samuel, Akeem Aderogba, Adeleke, Balogun, Simon, Ojo, Olugbenga, Olasehinde, Olalekan, Olugbami, Adebayo, Wuraola, Funmilola, Mohammed, Tajudeen, Afolabi, Abdulrahman O., Aremu, Isiaka, Ibraheem, Gbadebo, Odeyemi, Peter Olalekan, Olabinjo, Afusat, Raji, Hadijat Olaide, Salawu, Hafeez, Uche-Okonkwo, Kenechukwu, Anipole, Olalekan, Adesina, Oluwaseyi, Enwerem, Kenneth, Isichei, Mercy, Aghadi, Ifeanyi, Kache, Stephen, Lawal, Jamila, Taingson, Matthew, Yusuf, Nuhu, Sale, Danjuma, Takai, Idris Usman, Aji, Sani Ali, Anyanwu, Lofty-John, Bello-Muhammad, Nafisatu, Garzali, Ibrahim Umar, Hasheem, Muhammad Ghazali, Hassan, Sadiq, Ibrahim Usman, Mustapha, Magashi, Mahmoud Kawu, Mukhtar, Ibrahim Aliyu, Nwachukwu, Callistus, Suleiman, Ibrahim, A, Maryam, Mahmood, Farrukh, Salihu, Mohammed, Okereke, Chukwuma, Alegbeleye, Justina Omoikhefe, Awopeju, Abimbola, Fyneface-Ogan, Sotonye, Kasso, Terhemen, Onwuagha, Ijeoma, Salami, Babatunde, Ajagha, Okeoghene, Awaisu, Mudi, Nwabuoku, Stanley Emeka, Oyelowo, Nasir, Tolani, Musliu Adetola, Filipce, Venko, Rendevski, Vladimir, Shuntov, Blagoj, Todorovic, Lazar, Jovanovska, Katerina, Nikolovska, Bisera, Peev, Igor, Asha, Al Amri, Ayman, Al Badaai, Ghalib, Al Balushi, Zainab, Al Farsi, Maather, Al HOSNI, Mohammed, Al Kalbani, Moza, Al Riyami, Nihal, Al shaibi, Maha, Al-Mujaini, Abdullah, AlBusaidi, Hanadi, Alwashahi, Mohammed, Alzadjali, Adil, Dalmar, Khadija, Dawud, Bashar, Gargouri, Mohamed Mourad, Laghari, Farman Ali, Manjunatha, attibele Palaksha, Mathew, Joseph Kunju, Muzaffar, Rahil, Naiya, Hafsa Ismail Ibrahim, Pillai, Silja, Rahim, Ferdous, Stephen, Edwin, Younas, Shahzad, Fatima, Mishal, Javed, Ayesha, Shakir, Fatima Tuz Zahra, Siddiqui, Riaz Hussain, Sultan, Rizwan, Syed, Danish, Ur Rehman, Ishtiaq, Warraich, Shahrukh, Amir, Mohammed, Asghar, Saleha yurf, Haider Bangash, Ali, Ahmed, Arooj, Ansar, Mehwish, Arslan, Muhammad, Ashraf, Sumaira, Irshad, Abeer, Khan, Farheen, Shami, Dr Ali, Ul Haq, M Burhan, Waqar, Shahzad Hussain, Ahmed, Shahnoor, Ahsan, Kunwar Armash, Akhund, Ramsha, Chishti, Uzma, Haroon, Waqqas, Kassam, Nausheen, Kazmi, Abbas, Khan, Muhammad Osama, Kumari, Sameeta, Malik, Muhammad Jehangir, Mansoor, Maheen, Mubarik, Areeba, Naz, Falak, Qamar, Javeria Bilal, Sadia, Haleema, Safri, Mohammad, Sattar, abida K., Siddiqui, Muhammad Ahsan Iqbal, Waqar, Usama, Kerawala, Asad Ali, Ghufran, Muhammad Ali, Memon, Amjad Siraj, Rai, Lajpat, Samo, Khursheed Ahmed, Aswani, Manisha, Manzoor, Shahneela, Muhammad, Shoaib, Moin, Inshrah, Najjad, Muhammad Kazim Rahim, Zia, Kashif, Ali Shaikh, Shafqat, Ayub, Bushra, Hussaini, Dr, Kamal, Wajahat, Mughal, Zeeshan Uddin, Nadeem, Areeba, Nayyer, Fatima, Nisa, Kanwal, Rauf, Yaseen, Saleem, Shah Masabat, Sayyed, Raza, Shah, Aaqil, Siddiqui, Safia, Tariq, Nida, Zamir, Mehroz, Arif, Hafiz Muhammad, Ahmed, Ehsan, Ahmed, Jawad, Akbar, Bilal, Ali, Abrar Ashraf, Iqbal, Zafar, Jameel, Muhammad Khurram, Janjua, Muhammad Haris, Janjua, Azwa, Naqi, Syed Asghar, Naumeri, Fatima, Nazir, Umer, Rafi, Yaseen, Saleem, Irfan, Shaukat, Ayesha, Sikandar, Hafiz Saqib, Tu zahara, Fatima, Ali, Ahsan, Jawad, Muhammad, Noman, Hamza, Taha, Dr Hassan, Raana, Dr. Gul e, Qadir, Muhammad Ghulam, Ali, Imran, Asjad, Muhammad, Ayyaz, Mahmood, Bajwa, Luqman Ali, Bhatti, Samiullah, Butt, Usman, Chishti, Muhammad Haris, Hassan, Muhammad, Hassan, Usman, Hayat, Khizar, Khan, Rohma, Latif, Usman, Majeed, Faizan, Malik, Kiren, Nabi, Muhammad shoaib, Sadiq, Muhammad Hamza, Saeed, Komal, Sarfraz, Kiran, Sohail, Rubina, Syed muhammad, Bilal, Umair, Usama, Wasim, Shafqat, Wasim, Tayyiba, Imran Anwar, Muhammad, Ali, Ammar, Aslam, Muhammad, Sher e Murtaza, Muhammad, Farooq, Umer, Ahmad, Siddique, Faizi, Fouzia, Khan, Hamza, Mabood, Waleed, Akhtar, Muhammad Shaheer, Amin, Hasbi Allah, Ayub, Bakhtawar, Basir, Muhammad, Gul, Hina, Khan, Muhammad faisal, Moeen, Aiman, Mohmand, Obaid, Rahim, Rehana, Shafqat, Tanveer, Ur Rehman, Shams, Daud, Mashal, Abid, Rubaba, Farkhanda, Tallat, Malik, Sobia, Salim, Ruqyyah, Shaheen, Aneela, Ahmed, Faryal, Amjid, Zarafshan, Ishtiaq, Daniyal, Javed, Saad, Nagra, Ramisha Naseer, Saleem, Maleeha, Saleem, Bushra, Shabbir, Raja Khalid, Yaqoob, Eesha, Shaheen, Azka, Awad, Hadeel, Wafi, Dalia, Al-Slaibi, Ibrahim, I. A. 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Anna, Getz, Anne, Harmon, Laura, McIntyre, Robert, Meguid, Robert, Rodriguez, Kenny, Scott, Christopher, Steward, Lauren, Stewart, Camille, Thieu, Daniel, Velopulos, Catherine, Vogel, Jon, Bengtson, Erika, Hill, Charles, Holan, Cole, Kay, Hannah, McElhinney, Kathryn, Osterberg, E. Charles, Rossano, Ayane, Trust, Marc, Bigelow, Benjamin, Jain, Amit, Yesantharao, Lekha, Zhang, Bo, Abdou, Hossam, Mazzeffi, Michael, Rock, Peter, Afshar, Salim, Carlson, Laura, Incorvia, Joseph, Kurtz, Michael, Meara, John G., Nathan, Meena, Taghinia, Amir, Williams, Vivian, Cooper, Zara, Mahvi, David, Okafor, Barbara, Roxo, Vanessa, Burks, Ciersten, Jabbour, Nicolette, Sabra, Joseph, Wason, Shaun, Dorken Gallastegi, Ander, Gebran, Anthony, McTague, Michael, Reinke, Caroline, Ross, Samuel, Alvarado, Rosalinda, Bhama, Anuradha, Govekar, Henry, Kokosis, George, Millikan, Keith, Myers, Jonathan, Pappas, Sam, Siparsky, Nicole, Tsambarlis, Peter, Quillin, Ralph, Ekrami, Elyad, Kai, Li, Decker, Cassie, Aoun, Salah, Kwon, David, Barbas, Andrew, Dotters-Katz, Sarah K., Ellett, Tressa, Flamant, Etienne, Lazarides, Alexander, Refaat, Motasem, Soderlund, Torre, Velasquez, Camilo, Arrangoiz, Rodrigo, Mijares Olivo, Maria Fernanda, Vasudevan, Vanitha, Katz, Matthew, Nguyen, Huan, Pieretti, Alberto, Roland, Christina L, Baral, Perel, Beahm, D. 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Matthew, Ruzgar, Nensi Melissa, Alqunaibit, Dalia, Liveris, Anna, McNelis, John, Goldstein, Carma, Nguyen, Anh, Rattigan, Deviney, Solar, Sara, Tsui, Grace, Gaitanidis, Apostolos, Fitzmaurice, Laura, Jutric, Zeljka, Tay Lasso, Erika Linmey, Yamamoto, Maki, Meola, Antonio, Holena, Daniel, Imran, Jonathan, Lorenzi, Cara, Huckaby, Lauren, Hamandi, Mohanad, Lanfear, Allison T., Squiers, John, Behm, Kevin, Boughey, Judy, Reisenauer, Janani, Shawki, Sherief, Wigle, Dennis, Elshabrawy, Ahmed, Mansour, Ahmed, Todd, Grace Ihsiu, Yan, Qi, Curry, Terry, Abel, Mary Kathryn, Andaya, Veronica, Boeck, Marissa, Chen, Lee-may, Compadre, Amanda, Ha, Patrick, Kratz, Johannes R, Lane, Rondall, Lee, Rex H, Ozgediz, Doruk, Varma, Madhulika, Zimel, Melissa, Escobar, Pedro, Azam, Mohammad, Hammond, Eric, Marx, William, Angel, Carol, Seegert, Sara, Stanek, Stephen, Sumra, Hibba, Fischer, Anne, Henry, Jaymie, Lottenberg, Lawrence, Kelly, John, Scott, Erin, Bonilla Cal, Fernando, Haro, Camila, Álvarez, Sofia, Carbajal, Ana Carmen, PereiraNuñez, Diego, Tarigo, Josefina, Al-saban, Rafat, Al-Eryani, Fatima, Reem, Al sanany, Ghadeer, Al-jarmozi, Buthina, Al-ameri, Saba, Al-Shehari, Mohammed, Al-surimi, Dhyia Alhuq, Alakhdury, Amira, ALhumaida, Adnan, Aljabri, Maniee, ALodine, Marwa, Alqudaimi, Basma, Alsabri, Mohammed, Alsayadi, Musaed, Atiah, Nora, Sayad, Shaima, Shukri, Amal, Zeid, Shahd, Abdullah, Nabila, Al-Garadi, Abdulrahman Faisal, Ali Al-Radhi, Ahmed M., Naji, Norhan, Al-madhrahi, Ahmed, Al-maswari, Sakhr Abdulhakeem, Al-Raimi, Ibrahim, Alshargabi, Haneen, Mkandawire, Catherine, Nkole, Theresa, Chivanga, Shelton, Dube, Handsome, Mangena, Moses, Moyo, Nkosikhona, Tshuma, Oltah, Gwini, Grace, Moyana Muguto, Vimbai, Mushawarima, Trust, Shoko, Tinashe, Siamuchembu, Maphios, Jamela, Rorisang, Machiri, Marvellous, Mushiwokufa, Willard, Chimhina, Maxwell, Chinyowa, Simbarashe, Glasbey, James, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Arnaud, Alexis P, Ayasra, Faris, Azevedo, José, 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Abstract

Pulmonary complications are the most common cause of death after surgery. This study aimed to derive and externally validate a novel prognostic model that can be used before elective surgery to estimate the risk of postoperative pulmonary complications and to support resource allocation and prioritisation during pandemic recovery.

Published
2024
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47. P169 Childhood onset amyotrophic lateral sclerosis associated with SPTLC2 gain-of-function pathogenic variants: clinical, genetic, and biochemical insights

Author

Bach, R Or, primary, Syeda, S., additional, Mohassel, P., additional, Dohrn, M., additional, Lone, M., additional, Donkervoort, S., additional, Foley, A., additional, Beijer, D., additional, Bayraktar, E., additional, Oflazer, P., additional, Munot, P., additional, Rose, A., additional, Lyons, M., additional, Muntoni, F., additional, Başak, A., additional, Dunn, T., additional, Tornemann, H., additional, Süchner, Z., additional, and Bönnemann, C., additional

Published
2023
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49. Functional Thermoresponsive Hydrogel Molecule to Material Design for Biomedical Applications

Author

Sagar Pardeshi, Fouad Damiri, Mehrukh Zehravi, Rohit Joshi, Harshad Kapare, Mahendra Kumar Prajapati, Neha Munot, Mohammed Berrada, Prabhanjan S. Giram, Satish Rojekar, Faraat Ali, Md. Habibur Rahman, and Hasi Rani Barai

Subjects
hydrogel, thermoresponsive, release kinetics, biosensing, drug delivery, Organic chemistry, QD241-441
Abstract

Temperature-induced, rapid changes in the viscosity and reproducible 3-D structure formation makes thermos-sensitive hydrogels an ideal delivery system to act as a cell scaffold or a drug reservoir. Moreover, the hydrogels’ minimum invasiveness, high biocompatibility, and facile elimination from the body have gathered a lot of attention from researchers. This review article attempts to present a complete picture of the exhaustive arena, including the synthesis, mechanism, and biomedical applications of thermosensitive hydrogels. A special section on intellectual property and marketed products tries to shed some light on the commercial potential of thermosensitive hydrogels.

Published
2022
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50. A Comparative Study of Quercetin-Loaded Nanocochleates and Liposomes: Formulation, Characterization, Assessment of Degradation and In Vitro Anticancer Potential

Author

Neha Munot, Ujjwala Kandekar, Prabhanjan S. Giram, Kavita Khot, Abhinandan Patil, and Simona Cavalu

Subjects
nanocochleates, liposomes, quercetin, dimyristoyl phosphatidyl glycerol, human mouth cancerKB cell lines, rat liver homogenate (S9G), Pharmacy and materia medica, RS1-441
Abstract

Quercetin, a flavonoid, has antioxidant and anti-inflammatory properties and the potential to inhibit the proliferation of cancer, but its therapeutic efficacy is lowered due to poor solubility and bioavailability. Quercetin-loaded nanocochleates (QN) were developed using a trapping method by the addition of calcium ions into preformed negatively charged liposomes (QL) prepared by a thin-film hydration method. Liposomes were optimized by varying the concentration of Dimyristoyl phosphatidyl glycerol and quercetin by applying D-optimal factorial design using Design-Expert® software. Stable rods were observed using TEM with an average particle size, zeta potential and encapsulation efficiency of 502 nm, −18.52 mV and 88.62%, respectively, for QN which were developed from spherical QL showing 111.06 nm, −40.33 mV and 74.2%, respectively. In vitro release of quercetin from QN and QL was extended to 24 h. Poor bioavailability of quercetin is due to its degradation in the liver, so to mimic in vivo conditions, the degradation of quercetin released from QL and QN was studied in the presence of rat liver homogenate (S9G) and results revealed that QN, due to its unique structure, i.e., series of rolled up solid layers, shielded quercetin from the external environment and protected it. The safety and biocompatibility of QL and QN were provenby performing cytotoxicity studies on fibroblast L929 cell lines. QN showed superior anticancer activity compared to QL, as seen for human mouth cancerKB cell lines. Stability studies proved that nanocochleates were more stable than liposomal formulations. Thus, nanocochleates might serve as pharmaceutical nanocarriers for the improved efficacy of drugs with low aqueous solubility, poor bioavailability, poor targeting ability and stability.

Published
2022
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