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3. Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study

Author

Dolling, David I, Dunn, David T, Sutherland, Katherine A, Pillay, Deenan, Mbisa, Jean L, Parry, Chris M, Post, Frank A, Sabin, Caroline A, Cane, Patricia A, Aitken, Celia, Asboe, David, Webster, Daniel, Cane, Patricia, Castro, Hannah, Dunn, David, Dolling, David, Chadwick, David, Churchill, Duncan, Clark, Duncan, Collins, Simon, Delpech, Valerie, Geretti, Anna Maria, Goldberg, David, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh-Brown, Andrew, Mackie, Nicola, Orkin, Chloe, Rice, Philip, Phillips, Andrew, Sabin, Caroline, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Tong, William, Williams, Ian, Zhang, Hongyi, Zuckerman, Mark, Greatorex, Jane, Wildfire, Adrian, O'Shea, Siobhan, Mullen, Jane, Mbisa, Tamyo, Cox, Alison, Tandy, Richard, Hale, Tony, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia-Diaz, Ana, Shepherd, Jill, Schmid, Matthias L, Payne, Brendan, Hay, Phillip, Rice, Phillip, Paynter, Mary, Bibby, David, Kirk, Stuart, MacLean, Alasdair, Gunson, Rory, Coughlin, Kate, Fearnhill, Esther, Fradette, Lorraine, Porter, Kholoud, Ainsworth, Jonathan, Anderson, Jane, Babiker, Abdel, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hill, Teresa, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Nelson, Mark, Palfreeman, Adrian, Post, Frank, Sachikonye, Memory, Schwenk, Achim, Walsh, John, Huntington, Susie, Jose, Sophie, Thornton, Alicia, Glabay, Adam, Orkin, C, Garrett, N, Lynch, J, Hand, J, de Souza, C, Fisher, M, Perry, N, Tilbury, S, Gazzard, B, and Nelson, M

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Infectious Diseases, Antimicrobial Resistance, Clinical Research, Infection, Adult, Anti-HIV Agents, Atazanavir Sulfate, Cohort Studies, Drug Resistance, Viral, Female, HIV Infections, HIV Protease, HIV-1, Humans, Male, Medication Adherence, Middle Aged, Mutation Rate, Mutation, Missense, Oligopeptides, Pyridines, Treatment Failure, United States, UK HIV Drug Resistance Database, UK Collaborative HIV Cohort Study, HIV, drug resistance mutations, naive patients, protease inhibitors, virological failure, Microbiology, Pharmacology and Pharmaceutical Sciences, Clinical sciences, Pharmacology and pharmaceutical sciences
Abstract

ObjectivesTo determine protease mutations that develop at viral failure for protease inhibitor (PI)-naive patients on a regimen containing the PI atazanavir.MethodsResistance tests on patients failing atazanavir, conducted as part of routine clinical care in a multicentre observational study, were randomly matched by subtype to resistance tests from PI-naive controls to account for natural polymorphisms. Mutations from the consensus B sequence across the protease region were analysed for association and defined using the IAS-USA 2011 classification list.ResultsFour hundred and five of 2528 (16%) patients failed therapy containing atazanavir as a first PI over a median (IQR) follow-up of 1.76 (0.84-3.15) years and 322 resistance tests were available for analysis. Recognized major atazanavir mutations were found in six atazanavir-experienced patients (P < 0.001), including I50L and N88S. The minor mutations most strongly associated with atazanavir experience were M36I, M46I, F53L, A71V, V82T and I85V (P < 0.05). Multiple novel mutations, I15S, L19T, K43T, L63P/V, K70Q, V77I and L89I/T/V, were also associated with atazanavir experience.ConclusionsViral failure on atazanavir-containing regimens was not common and major resistance mutations were rare, suggesting that adherence may be a major contributor to viral failure. Novel mutations were described that have not been previously documented.

Published
2013

8. Recent trends and patterns in HIV‐1 transmitted drug resistance in the United Kingdom

Author

Tostevin, A, White, E, Dunn, D, Croxford, S, Delpech, V, Williams, I, Asboe, D, Pozniak, A, Churchill, D, Geretti, AM, Pillay, D, Sabin, C, LeighBrown, A, Smit, E, Aitken, Celia, Cane, Patricia, Chadwick, David, Clark, Duncan, Collins, Simon, Douthwaite, Samuel, Fearnhill, Esther, Porter, Kholoud, Fraser, Christophe, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Mbisa, Tamyo, Mackie, Nicola, Moses, Samuel, Orkin, Chloe, Nastouli, Eleni, Phillips, Andrew, Templeton, Kate, Tilston, Peter, Zhang, Hongyi, Fairbrother, Keith, Greatorex, Jane, OʼShea, Siobhan, Mullen, Jane, Cox, Alison, Tandy, Richard, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynne, Booth, Clare, GarciaDiaz, Ana, Shepherd, Jill, Schmid, Matthias L., Payne, Brendan, Pereira, Spiro, Hubb, Jonathan, Kirk, Stuart, Gunson, Rory, and BradleyStewart, Amanda

Published
2017
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13. Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a single-centre laboratory evaluation study

Author

Pickering, Suzanne, primary, Batra, Rahul, additional, Merrick, Blair, additional, Snell, Luke B, additional, Nebbia, Gaia, additional, Douthwaite, Sam, additional, Reid, Fiona, additional, Patel, Amita, additional, Kia Ik, Mark Tan, additional, Patel, Bindi, additional, Charalampous, Themoula, additional, Alcolea-Medina, Adela, additional, Lista, Maria Jose, additional, Cliff, Penelope R, additional, Cunningham, Emma, additional, Mullen, Jane, additional, Doores, Katie J, additional, Edgeworth, Jonathan D, additional, Malim, Michael H, additional, Neil, Stuart J D, additional, and Galão, Rui Pedro, additional

Published
2021
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16. Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy

Author

Easterbrook, Philippa J., Smith, Mel, Mullen, Jane, O'Shea, Siobhan, Chrystie, Ian, Ruiter, Annemiek, Tatt, Iain D., Geretti, Anna Maria, and Zuckerman, Mark

Subjects
Highly active antiretroviral therapy -- Patient outcomes, HIV infection -- Development and progression -- Care and treatment -- Demographic aspects, Health
Abstract

Background: Our intention was to compare the rate of immunological progression prior to antiretroviral therapy (ART) and the virological response to ART in patients infected with subtype B and four non‐B HIV‐1 subtypes (A, C, D and the circulating recombinant form, CRF02‐AG) in an ethnically diverse population of HIV‐1‐infected patients in south London. Methods: A random sample of 861 HIV‐1‐infected patients attending HIV clinics at King's and St Thomas' hospitals' were subtyped using an in‐house enzyme‐linked immunoassay and env sequencing. Subtypes were compared on the rate of CD4 cell decline using a multi‐level random effects model. Virological response to ART was compared using the time to virological suppression (< 400 copies/ml) and rate of virological rebound (> 400 copies/ml) following initial suppression. Results: Complete subtype and epidemiological data were available for 679 patients, of whom 357 (52.6%) were white and 230 (33.9%) were black African. Subtype B (n = 394) accounted for the majority of infections, followed by subtypes C (n = 125), A (n = 84), D (n = 51) and CRF02‐AG (n = 25). There were no significant differences in rate of CD4 cell decline, initial response to highly active antiretroviral therapy and subsequent rate of virological rebound for subtypes B, A, C and CRF02‐AG. However, a statistically significant four‐fold faster rate of CD4 decline (after adjustment for gender, ethnicity and baseline CD4 count) was observed for subtype D. In addition, subtype D infections showed a higher rate of virological rebound at six months (70%) compared with subtypes B (45%, p = 0.02), A (35%, p = 0.004) and C (34%, p = 0.01) Conclusions: This is the first study from an industrialized country to show a faster CD4 cell decline and higher rate of subsequent virological failure with subtype D infection. Further studies are needed to identify the molecular mechanisms responsible for the greater virulence of subtype D., Introduction The world‐wide HIV epidemic has been characterized by increasing genetic diversity, with multiple distinct viral subtypes, as well as sub‐subtypes, and circulating recombinant forms (CRFs) [1‐3]. At present, specific [...]

Published
2010
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17. Safety leadership: a longitudinal study of the effect of transformational leadership on safety outcomes

Author

Mullen, Jane E. and Kelloway, E. Kevin

Subjects
Leadership styles -- Influence, Occupational health and safety -- Management, Company business management, Human resources and labor relations, Psychology and mental health
Abstract

The study examines the effect of transformational leadership on an organization's safety outcomes and finds that leadership training leads to higher ratings of managers' safety attitudes. Leadership training's impact on employee safety attitudes is also assessed.

Published
2009

18. Comparative performance of SARS CoV-2 lateral flow antigen tests demonstrates their utility for high sensitivity detection of infectious virus in clinical specimens

Author

Pickering, Suzanne, primary, Batra, Rahul, additional, Snell, Luke B., additional, Merrick, Blair, additional, Nebbia, Gaia, additional, Douthwaite, Sam, additional, Patel, Amita, additional, Ik, Mark Tan Kia, additional, Patel, Bindi, additional, Charalampous, Themoula, additional, Alcolea-Medina, Adela, additional, Lista, Maria Jose, additional, Cliff, Penelope R., additional, Cunningham, Emma, additional, Mullen, Jane, additional, Doores, Katie J., additional, Edgeworth, Jonathan D., additional, Malim, Michael H., additional, Neil, Stuart J.D., additional, and Galão, Rui Pedro, additional

Published
2021
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24. Associations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz + tenofovir + emtricitabine for HIV

Author

Stirrup, Oliver T., primary, Sabin, Caroline A., additional, Phillips, Andrew N., additional, Williams, Ian, additional, Churchill, Duncan, additional, Tostevin, Anna, additional, Hill, Teresa, additional, Dunn, David T., additional, Asboe, David, additional, Pozniak, Anton, additional, Cane, Patricia, additional, Chadwick, David, additional, Clark, Duncan, additional, Collins, Simon, additional, Delpech, Valerie, additional, Douthwaite, Samuel, additional, Dunn, David, additional, Fearnhill, Esther, additional, Porter, Kholoud, additional, Stirrup, Oliver, additional, Fraser, Christophe, additional, Geretti, Anna Maria, additional, Gunson, Rory, additional, Hale, Antony, additional, Hué, Stéphane, additional, Lazarus, Linda, additional, Leigh-Brown, Andrew, additional, Mbisa, Tamyo, additional, Mackie, Nicola, additional, Orkin, Chloe, additional, Nastouli, Eleni, additional, Pillay, Deenan, additional, Phillips, Andrew, additional, Sabin, Caroline, additional, Smit, Erasmus, additional, Templeton, Kate, additional, Tilston, Peter, additional, Volz, Erik, additional, Zhang, Hongyi, additional, Fairbrother, Keith, additional, Dawkins, Justine, additional, O’Shea, Siobhan, additional, Mullen, Jane, additional, Cox, Alison, additional, Tandy, Richard, additional, Fawcett, Tracy, additional, Hopkins, Mark, additional, Booth, Clare, additional, Renwick, Lynne, additional, Schmid, Matthias L., additional, Payne, Brendan, additional, Hubb, Jonathan, additional, Dustan, Simon, additional, Kirk, Stuart, additional, Bradley-Stewart, Amanda, additional, Jose, Sophie, additional, Thornton, Alicia, additional, Huntington, Susie, additional, Glabay, Adam, additional, Shidfar, Shaadi, additional, Lynch, Janet, additional, Hand, James, additional, de Souza, Carl, additional, Perry, Nicky, additional, Tilbury, Stuart, additional, Youssef, Elaney, additional, Gazzard, Brian, additional, Nelson, Mark, additional, Mabika, Tracey, additional, Mandalia, Sundhiya, additional, Anderson, Jane, additional, Munshi, Sajid, additional, Post, Frank, additional, Adefisan, Ade, additional, Taylor, Chris, additional, Gleisner, Zachary, additional, Ibrahim, Fowzia, additional, Campbell, Lucy, additional, Baillie, Kirsty, additional, Gilson, Richard, additional, Brima, Nataliya, additional, Ainsworth, Jonathan, additional, Schwenk, Achim, additional, Miller, Sheila, additional, Wood, Chris, additional, Johnson, Margaret, additional, Youle, Mike, additional, Lampe, Fiona, additional, Smith, Colette, additional, Tsintas, Rob, additional, Chaloner, Clinton, additional, Hutchinson, Samantha, additional, Walsh, John, additional, Mackie, Nicky, additional, Winston, Alan, additional, Weber, Jonathan, additional, Ramzan, Farhan, additional, Carder, Mark, additional, Leen, Clifford, additional, Wilson, Alan, additional, Morris, Sheila, additional, Gompels, Mark, additional, Allan, Sue, additional, Palfreeman, Adrian, additional, Lewszuk, Adam, additional, Kegg, Stephen, additional, Faleye, Akin, additional, Ogunbiyi, Victoria, additional, Mitchell, Sue, additional, Hay, Phillip, additional, Kemble, Christian, additional, Martin, Fabiola, additional, Russell-Sharpe, Sarah, additional, Gravely, Janet, additional, Allan, Sris, additional, Harte, Andrew, additional, Tariq, Anjum, additional, Spencer, Hazel, additional, Jones, Ron, additional, Pritchard, Jillian, additional, Cumming, Shirley, additional, Atkinson, Claire, additional, Mital, Dushyant, additional, Edgell, Veronica, additional, Allen, Juli, additional, Ustianowski, Andy, additional, Murphy, Cynthia, additional, Gunder, Ilise, additional, Trevelion, Roy, additional, and Babiker, Abdel, additional

Published
2019
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34. Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation

Author

Jose, S., Quinn, K., Dunn, D., Cox, A., Sabin, C., Fidler, S., Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hay, Phillip, Johnson, Margaret, Kegg, Stephen, Leen, C., Martin, Fabiola, Nelson, Mark, Palfreeman, Adrian, Post, F., Pritchard, Jillian, Sachikonye, Memory, Schwenk, Achim, Tariq, Anjum, Walsh, John, Hill, Teresa, Jose, Sophie, Phillips, Andrew, Sabin, Caroline, Thornton, Alicia, Dunn, David, Glabay, Adam, Fisher, M., Perry, N., Tilbury, S., Youssef, E., Churchill, D., Gazzard, B., Nelson, M., Everett, R., Asboe, D., Mandalia, S., Korat, H., Taylor, C., Gleisner, Z., Ibrahim, F., Campbell, L., Gilson, R., Brima, N., Williams, I., Johnson, M., Youle, M., Lampe, F., Smith, C., Tsintas, R., Chaloner, C., Hutchinson, S., Phillips, A., Hill, T., Thornton, A., Huntington, S., Walsh, J., Mackie, N., Winston, A., Weber, J., Ramzan, F., Carder, M., Orkin, C., Lynch, J., Hand, J., de Souza, C., Anderson, J., Munshi, S., Ainsworth, J., Schwenk, A., Miller, S., Wood, C., Wilson, A., Morris, S., Gompels, M., Allan, S., Palfreeman, A., Memon, K., Lewszuk, A., Chadwick, D., Cope, E., Gibson, J., Kegg, S., Main, P., Mitchell, Hunter, Hay, P., Dhillon, M., Martin, F., Russell-Sharpe, S., Harte, A., Clay, S., Tariq, A., Spencer, H., Jones, R., Pritchard, J., Cumming, S., Atkinson, C., Delpech, Valerie, Sachikony, M., Aitken, Celia, Asboe, David, Pozniak, Anton, Cane, Patricia, Chadwick, David, Churchill, Duncan, Clark, Duncan, Collins, Simon, Douthwaite, Samuel, Fearnhill, Esther, Porter, Kholoud, Tostevin, Anna, White, Ellen, Fraser, Christophe, Geretti, Anna Maria, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh-Brown, Andrew, Mbisa, Tamyo, Mackie, Nicola, Moses, Samuel, Orkin, Chloe, Nastouli, Eleni, Pillay, Deenan, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Webster, Daniel, Williams, Ian, Zhang, Hongyi, Greatorex, Jane, O'Shea, Siobhan, Mullen, Jane, Cox, Alison, Tandy, Richard, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia-Diaz, Ana, Shepherd, Jill, Schmid, Matthias L., Payne, Brendan, Pereira, Spiro, Hubb, Jonathan, Kirk, Stuart, Gunson, Rory, Bradley-Stewart, Amanda, and Medical Research Council (MRC)

Subjects
0301 basic medicine, Male, HAART, HIV Infections, Treatment failure, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Antiretroviral Therapy, Highly Active, Pharmacology (medical), 030212 general & internal medicine, Treatment Failure, virological failure, Health Policy, UK CHIC and UK HDRD Steering Committees, Virological failure, 3. Good health, Antiretroviral therapy, Patient benefit, Infectious Diseases, Female, medicine.symptom, Life Sciences & Biomedicine, Viral load, Cart, medicine.medical_specialty, Anti-HIV Agents, Short Communication, antiretroviral therapy, CD4 count, Asymptomatic, 03 medical and health sciences, HIV-INFECTION, Virology, Internal medicine, Drug Resistance, Viral, medicine, Humans, Science & Technology, business.industry, HIV resistance, 1103 Clinical Sciences, 030112 virology, CD4 Lymphocyte Count, Immunology, Mutation, business
Abstract

Objectives No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4 counts > 350 cells/μL. It is hypothesized that earlier initiation of cART in asymptomatic and otherwise healthy individuals may lead to poorer adherence and subsequently higher rates of resistance development. Methods In a large cohort of HIV-positive individuals, we investigated the emergence of new resistance mutations upon virological treatment failure according to the CD4 count at the initiation of cART. Results Of 7918 included individuals, 6514 (82.3%), 996 (12.6%) and 408 (5.2%) started cART with a CD4 count ≤ 350, 351–499 and ≥ 500 cells/μL, respectively. Virological rebound occurred while on cART in 488 (7.5%), 46 (4.6%) and 30 (7.4%) with a baseline CD4 count ≤ 350, 351–499 and ≥ 500 cells/μL, respectively. Only four (13.0%) individuals with a baseline CD4 count > 350 cells/μL in receipt of a resistance test at viral load rebound were found to have developed new resistance mutations. This compared to 107 (41.2%) of those with virological failure who had initiated cART with a CD4 count

Published
2015

35. Deserters

Author

Mullen, Jane Ann

Published
1989

45. Brotherly love

Author

Mullen, Jane Ann

Subjects
Short stories, Fashion and beauty, General interest
Published
1985

50. Evidence for horizontal and not vertical transmission of human herpesvirus 8 in children born to human immunodeficiency virus-infected mothers

Author

LYALL, E. G. HERMIONE, primary, PATTON, GILLIAN S., additional, SHELDON, JULIE, additional, STAINSBY, CHRIS, additional, MULLEN, JANE, additional, O'SHEA, SIOBHAN, additional, SMITH, NICOLA A., additional, DE RUITER, ANNEMIEK, additional, MCCLURE, MYRA O., additional, and SCHULZ, THOMAS F., additional

Published
1999
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