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1. Previous immune checkpoint inhibitor therapy is associated with decreased COVID-19-related hospitalizations and complications in patients with cancer: Results of a propensity-matched analysis of the OnCovid registry

Author: Mostaghim, Anahita, Minkove, Samuel, Aguilar-Company, Juan, Ruiz-Camps, Isabel, Eremiev-Eremiev, Simeon, Dettorre, Gino M., Fox, Laura, Tondini, Carlo, Brunet, Joan, Carmona-García, MCarmen, Lambertini, Matteo, Bower, Mark, Newsom-Davis, Thomas, Sharkey, Rachel, Pria, Alessia Dalla, Rossi, Maura, Plaja, Andrea, Salazar, Ramon, Sureda, Anna, Prat, Aleix, Michalarea, Vasiliki, Van Hemelrijck, Mieke, Sita-Lumsden, Ailsa, Bertuzzi, Alexia, Rimassa, Lorenza, Rossi, Sabrina, Rizzo, Gianpiero, Pedrazzoli, Paolo, Lee, Alvin JX, Murphy, Cian, Belessiotis, Katherine, Diamantis, Nikolaos, Mukherjee, Uma, Pommeret, Fanny, Stoclin, Annabelle, Martinez-Vila, Clara, Bruna, Riccardo, Gaidano, Gianluca, D'Avanzo, Francesca, Gennari, Alessandra, Athale, Janhavi, Eichacker, Peter, Pinato, David J., Torabi-Parizi, Parizad, and Cortellini, Alessio
Published: 2024
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2. SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

Author: Evans, Joanne S, Swallow, Judith, Hanbury, Georgina, Chung, Chris, Patel, Meera, Dettorre, Gino, Belessiotis, Katherine, Saorise, Dolly, Jones, Eleanor, Apthorp, Eleanor, Moss, Charlotte, Russell, Beth, Townsend, Sarah, Jackson, Amanda, Loizidou, Angela, Piccart, Martine, Pommeret, Fanny, Colomba-Blameble, Emeline, Prat, Aleix, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Felip, Eudald, Scotti, Lorenza, Marrari, Andrea, Grosso, Federica, Fusco, Vittorio, Delfanti, Sara, Rossi, Maura, Zambelli, Alberto, Tondini, Carlo, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Provenzano, Salvatore, Generali, Daniele, Grisanti, Salvatore, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Saponara, Maristella, Filetti, Marco, Tucci, Marco, Berardi, Rossana, Cantini, Luca, Paoloni, Francesco, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Sanchez de Torre, Ana, Tagliamento, Marco, Cortellini, Alessio, Tabernero, Josep, Mukherjee, Uma, Salazar, Ramon, Sureda, Anna, Maluquer, Clara, Ferrante, Daniela, Bower, Mark, Sharkey, Rachel, Mirallas, Oriol, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Dalla Pria, Alessia, Newsom-Davis, Thomas, Van Hemelrijck, Mieke, Sita-Lumsden, Ailsa, Vincenzi, Bruno, Di Fazio, Giuseppina Rita, Tonini, Giuseppe, Pantano, Francesco, Bertuzzi, Alexia, Rossi, Sabrina, Brunet, Joan, Lambertini, Matteo, Pedrazzoli, Paolo, Biello, Federica, D'Avanzo, Francesca, Lee, Alvin J X, Shawe-Taylor, Marianne, Rogers, Lucy, Murphy, Cian, Cooper, Lee, Andaleeb, Ramis, Khalique, Saira, Bawany, Samira, Ahmed, Sarah, Carmona-García, M Carmen, Fort-Culillas, Roser, Liñan, Raquel, Zoratto, Federica, Rizzo, Gianpiero, Perachino, Marta, Doonga, Kris, Gaidano, Gianluca, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Pérez Criado, Ignacio, Giusti, Raffaele, Mazzoni, Francesca, Antonuzzo, Lorenzo, Santoro, Armando, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Diamantis, Nikolaos, Bertulli, Rossella, Fulgenzi, Claudia A M, D'Alessio, Antonio, Ruiz-Camps, Isabel, Saoudi-Gonzalez, Nadia, Garcia Illescas, David, Medina, Irene, Fox, Laura, Gennari, Alessandra, Aguilar-Company, Juan, and Pinato, David J
Published: 2023
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3. Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study

Author: Evans, Joanne S, Swallow, Judith, Chung, Chris, Patel, Meera, Dettorre, Gino, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Chopra, Neha, Lee, Alvin JX, Sng, Christopher CT, Yu, Tamara, Shawe-Taylor, Marianne, Bain, Hamish DC, Wong, Yien Ning Sophia, Galazi, Myria, Benafif, Sarah, Dileo, Palma, Earnshaw, Irina, Patel, Grisma, Wu, Anjui, Soosaipillai, Gehan, Cooper, Lee, Andaleeb, Ramis, Dolly, Saoirse, Apthorp, Eleanor, Srikandarajah, Krishnie, Jones, Eleanor, Van Hemelrijck, Mieke, Moss, Charlotte, Russell, Beth, Chester, John, Loizidou, Angela, Piccart, Martine, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Eremiev, Simeon, Fort-Culillas, Roser, Garcia, Isabel, Liñan, Raquel, Roqué Lloveras, Ariadna, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Felip, Eudald, Pous, Anna, D'Avanzo, Francesca, Scotti, Lorenza, Krengli, Marco, Marrari, Andrea, Delfanti, Sara, Maconi, Antonio, Betti, Marta, Tonini, Giuseppe, Di Fazio, Giuseppina Rita, Tondini, Carlo, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Bertulli, Rossella, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Saponara, Maristella, Filetti, Marco, Zoratto, Federica, Paoloni, Francesco, Berardi, Rossana, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Sanchez de Torre, Ana, Tagliamento, Marco, Colomba, Emeline, Pommeret, Fanny, Pinato, David J, Aguilar-Company, Juan, Ferrante, Daniela, Hanbury, Georgina, Bower, Mark, Salazar, Ramon, Mirallas, Oriol, Sureda, Anna, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Townsend, Sarah, Jackson, Amanda, Dalla Pria, Alessia, Newsom-Davis, Thomas, Handford, Jasmine, Sita-Lumsden, Ailsa, Vincenzi, Bruno, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Maluquer, Clara, Pedrazzoli, Paolo, Biello, Federica, Sinclair, Alasdair, Bawany, Samira, Khalique, Saira, Rossi, Sabrina, Rogers, Lucy, Murphy, Cian, Belessiotis, Katherine, Carmona-García, M Carmen, Sharkey, Rachel, García-Illescas, David, Rizzo, Gianpiero, Perachino, Marta, Saoudi-Gonzalez, Nadia, Doonga, Kris, Fox, Laura, Roldán, Elisa, Gaidano, Gianluca, Ruiz-Camps, Isabel, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Cantini, Luca, Zambelli, Alberto, Giusti, Raffaele, Mazzoni, Francesca, Caliman, Enrico, Santoro, Armando, Grosso, Federica, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Prat, Aleix, Tucci, Marco, Grisanti, Salvatore, Mukherjee, Uma, Diamantis, Nikolaos, Fusco, Vittorio, Generali, Daniele, Provenzano, Salvatore, Gennari, Alessandra, Tabernero, Josep, and Cortellini, Alessio
Published: 2022
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4. Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study

Author: Swallow, Judith, Chung, Chris, Dettorre, Gino, Chopra, Neha, Lee, Alvin JX, Sng, Christopher CT, Wong, Yien Ning Sophia, Galazi, Myria, Benafif, Sarah, Dileo, Palma, Patel, Grisma, Wu, Anjui, Sinclair, Alasdair, Soosaipillai, Gehan, Jones, Eleanor, Diamantis, Nikolaos, Mukherjee, Uma, Jackson, Amanda, Piccart, Martine, Pommeret, Fanny, Colomba, Johann, Colomba-Blameble, Emeline, Prat, Aleix, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Tabernero, Josep, Aguilar-Company, Juan, Ruiz-Camps, Isabel, Fox, Laura, Garcia Illescas, David, Mirallas, Oriol, Roldán, Elisa, Carbó, Anna, Garcia, Isabel, Wuerstlein, Rachel, Mesia, Ricard, Maluquer, Clara, D'Avanzo, Francesca, Tonini, Giuseppe, Provenzano, Salvatore, Tovazzi, Valeria, Ficorella, Corrado, Queirolo, Paola, Giusti, Raffaele, Mazzoni, Francesca, Zoratto, Federica, Tucci, Marco, Berardi, Rossana, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Pinato, David J, Bower, Mark, Scotti, Lorenza, Patel, Meera, Colomba, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Zambelli, Alberto, Dalla Pria, Alessia, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Tagliamento, Marco, Pous, Anna, Sita-Lumsden, Ailsa, Srikandarajah, Krishnie, Seguí, Elia, Generali, Daniele, Grisanti, Salvatore, Pedrazzoli, Paolo, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S, Russell, Beth, Harbeck, Nadia, Vincenzi, Bruno, Biello, Federica, Bertulli, Rossella, Liñan, Raquel, Rossi, Sabrina, Carmona-García, Maria Carmen, Tondini, Carlo, Baggi, Alice, Fotia, Vittoria, Parisi, Alessandro, Porzio, Giampero, Saponara, Maristella, Cruz, Claudia Andrea, García-Illescas, David, Felip, Eudald, Roqué Lloveras, Ariadna, Sharkey, Rachel, Earnshaw, Irina, Ferrante, Daniela, Gaidano, Gianluca, Patriarca, Andrea, Bruna, Riccardo, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Cantini, Luca, Filetti, Marco, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Van Hemelrijck, Mieke, Newsom-Davis, Thomas, Gennari, Alessandra, and Cortellini, Alessio
Published: 2021
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5. Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4

Author: Ghose, Aruni, primary, McCann, Lucy, additional, Makker, Shania, additional, Mukherjee, Uma, additional, Gullapalli, Sri Vidya Niharika, additional, Erekkath, Jayaraj, additional, Shih, Stephanie, additional, Mahajan, Ishika, additional, Sanchez, Elisabet, additional, Uccello, Mario, additional, Moschetta, Michele, additional, Adeleke, Sola, additional, and Boussios, Stergios, additional
Published: 2024
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6. Impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in patients with soft tissue sarcoma: an analysis from the OnCovid registry

Author: Vincenzi, Bruno, primary, Cortellini, Alessio, additional, Mazzocca, Alessandro, additional, Orlando, Sarah, additional, Romandini, Davide, additional, Aguilar-Company, Juan, additional, Ruiz-Camps, Isabel, additional, Valverde Morales, Claudia, additional, Eremiev-Eremiev, Simeon, additional, Tondini, Carlo, additional, Brunet, Joan, additional, Bertulli, Rossella, additional, Provenzano, Salvatore, additional, Bower, Mark, additional, Generali, Daniele, additional, Salazar, Ramon, additional, Sureda, Anna, additional, Prat, Aleix, additional, Vasiliki, Michalarea, additional, Van Hemelrijck, Mieke, additional, Sita-Lumsden, Ailsa, additional, Bertuzzi, Alexia, additional, Rossi, Sabrina, additional, Jackson, Amanda, additional, Grosso, Federica, additional, Lee, Alvin J. X., additional, Murphy, Cian, additional, Belessiotis, Katherine, additional, Mukherjee, Uma, additional, Pommeret, Fanny, additional, Loizidou, Angela, additional, Gaidano, Gianluca, additional, Dettorre, Gino M., additional, Grisanti, Salvatore, additional, Tucci, Marco, additional, Fulgenzi, Claudia A. M., additional, Gennari, Alessandra, additional, Napolitano, Andrea, additional, and Pinato, David J., additional
Published: 2024
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7. Pandemic Phase-Adjusted Analysis of COVID-19 Outcomes Reveals Reduced Intrinsic Vulnerability and Substantial Vaccine Protection From Severe Acute Respiratory Syndrome Coronavirus 2 in Patients With Breast Cancer

Author: Tagliamento, Marco, primary, Gennari, Alessandra, additional, Lambertini, Matteo, additional, Salazar, Ramon, additional, Harbeck, Nadia, additional, Del Mastro, Lucia, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sharkey, Rachel, additional, Dalla Pria, Alessia, additional, Plaja, Andrea, additional, Jackson, Amanda, additional, Handford, Jasmine, additional, Sita-Lumsden, Ailsa, additional, Martinez-Vila, Clara, additional, Matas, Marta, additional, Miguel Rodriguez, Ana, additional, Vincenzi, Bruno, additional, Tonini, Giuseppe, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Pedrazzoli, Paolo, additional, D'Avanzo, Francesca, additional, Biello, Federica, additional, Sinclair, Alasdair, additional, Lee, Alvin J.X., additional, Rossi, Sabrina, additional, Rizzo, Gianpiero, additional, Mirallas, Oriol, additional, Pimentel, Isabel, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, Guida, Annalisa, additional, Berardi, Rossana, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Filetti, Marco, additional, Mazzoni, Francesca, additional, Mukherjee, Uma, additional, Diamantis, Nikolaos, additional, Parisi, Alessandro, additional, Aujayeb, Avinash, additional, Prat, Aleix, additional, Libertini, Michela, additional, Grisanti, Salvatore, additional, Rossi, Maura, additional, Zoratto, Federica, additional, Generali, Daniele, additional, Saura, Cristina, additional, Lyman, Gary H., additional, Kuderer, Nicole M., additional, Pinato, David J., additional, and Cortellini, Alessio, additional
Published: 2023
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8. SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

Author: Cortellini, Alessio, primary, Tabernero, Josep, additional, Mukherjee, Uma, additional, Salazar, Ramon, additional, Sureda, Anna, additional, Maluquer, Clara, additional, Ferrante, Daniela, additional, Bower, Mark, additional, Sharkey, Rachel, additional, Mirallas, Oriol, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, Mesia, Ricard, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Van Hemelrijck, Mieke, additional, Sita-Lumsden, Ailsa, additional, Apthorp, Eleanor, additional, Vincenzi, Bruno, additional, Di Fazio, Giuseppina Rita, additional, Tonini, Giuseppe, additional, Pantano, Francesco, additional, Bertuzzi, Alexia, additional, Rossi, Sabrina, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, D'Avanzo, Francesca, additional, Lee, Alvin J X, additional, Shawe-Taylor, Marianne, additional, Rogers, Lucy, additional, Murphy, Cian, additional, Cooper, Lee, additional, Andaleeb, Ramis, additional, Khalique, Saira, additional, Bawany, Samira, additional, Ahmed, Sarah, additional, Carmona-García, M Carmen, additional, Fort-Culillas, Roser, additional, Liñan, Raquel, additional, Zoratto, Federica, additional, Rizzo, Gianpiero, additional, Perachino, Marta, additional, Doonga, Kris, additional, Gaidano, Gianluca, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Martinez-Vila, Clara, additional, Pérez Criado, Ignacio, additional, Giusti, Raffaele, additional, Mazzoni, Francesca, additional, Antonuzzo, Lorenzo, additional, Santoro, Armando, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Diamantis, Nikolaos, additional, Bertulli, Rossella, additional, Fulgenzi, Claudia A M, additional, D'Alessio, Antonio, additional, Ruiz-Camps, Isabel, additional, Saoudi-Gonzalez, Nadia, additional, Garcia Illescas, David, additional, Medina, Irene, additional, Fox, Laura, additional, Gennari, Alessandra, additional, Aguilar-Company, Juan, additional, Pinato, David J, additional, Evans, Joanne S, additional, Swallow, Judith, additional, Hanbury, Georgina, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Belessiotis, Katherine, additional, Saorise, Dolly, additional, Jones, Eleanor, additional, Moss, Charlotte, additional, Russell, Beth, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Pommeret, Fanny, additional, Colomba-Blameble, Emeline, additional, Prat, Aleix, additional, Cruz, Claudia A, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Felip, Eudald, additional, Scotti, Lorenza, additional, Marrari, Andrea, additional, Grosso, Federica, additional, Fusco, Vittorio, additional, Delfanti, Sara, additional, Rossi, Maura, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Libertini, Michela, additional, Provenzano, Salvatore, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Filetti, Marco, additional, Tucci, Marco, additional, Berardi, Rossana, additional, Cantini, Luca, additional, Paoloni, Francesco, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, and Tagliamento, Marco, additional
Published: 2023
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9. Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy

Author: Carpentier,JosÃ©phine, Pavlyk,Iuliia, Mukherjee,Uma, Hall,Peter E, and Szlosarek,Peter W
Subjects: Targets and Therapy [Lung Cancer]
Abstract: JosÃ©phine Carpentier,1 Iuliia Pavlyk,1 Uma Mukherjee,2 Peter E Hall,2 Peter W Szlosarek1,2 1Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK; 2Department of Medical Oncology, Barts Health NHS Trust, St. Bartholomewâs Hospital, London, EC1A 7BE, UKCorrespondence: Peter W Szlosarek, Centre for Molecular Oncology, Queen Mary University of London, Charterhouse Square, London, EC1M 6BG, United Kingdom, Tel +44 0 20 7882 3559, Fax +44 0 20 7882 3884, Email p.w.szlosarek@qmul.ac.ukAbstract: Arginine deprivation has gained increasing traction as a novel and safe antimetabolite strategy for the treatment of several hard-to-treat cancers characterised by a critical dependency on arginine. Small cell lung cancer (SCLC) displays marked arginine auxotrophy due to inactivation of the rate-limiting enzyme argininosuccinate synthetase 1 (ASS1), and as a consequence may be targeted with pegylated arginine deiminase or ADI-PEG20 (pegargiminase) and human recombinant pegylated arginases (rhArgPEG, BCT-100 and pegzilarginase). Although preclinical studies reveal that ASS1-deficient SCLC cell lines are highly sensitive to arginine-degrading enzymes, there is a clear disconnect with the clinic with minimal activity seen to date that may be due in part to patient selection. Recent studies have explored resistance mechanisms to arginine depletion focusing on tumor adaptation, such as ASS1 re-expression and autophagy, stromal cell inputs including macrophage infiltration, and tumor heterogeneity. Here, we explore how arginine deprivation may be combined strategically with novel agents to improve SCLC management by modulating resistance and increasing the efficacy of existing agents. Moreover, recent work has identified an intriguing role for targeting arginine in combination with PD-1/PD-L1 immune checkpoint inhibitors and clinical trials are in progress. Thus, future studies of arginine-depleting agents with chemoimmunotherapy, the current standard of care for SCLC, may lead to enhanced disease control and much needed improvements in long-term survival for patients.Keywords: small cell lung cancer, SCLC, arginine, argininosuccinate synthase 1, ASS1, arginine deprivation, tumor microenvironment, immunotherapy
Published: 2022

10. Immune checkpoint inhibitor therapy and outcomes from SARS-CoV-2 infection in patients with cancer: a joint analysis of OnCovid and ESMO-CoCARE registries

Author: Cortellini, Alessio, primary, Dettorre, Gino M, additional, Dafni, Urania, additional, Aguilar-Company, Juan, additional, Castelo-Branco, Luis, additional, Lambertini, Matteo, additional, Gennatas, Spyridon, additional, Angelis, Vasileios, additional, Sita-Lumsden, Ailsa, additional, Rogado, Jacobo, additional, Pedrazzoli, Paolo, additional, Viñal, David, additional, Prat, Aleix, additional, Rossi, Maura, additional, Berardi, Rossana, additional, Alonso-Gordoa, Teresa, additional, Grisanti, Salvatore, additional, Dimopoulou, Georgia, additional, Queirolo, Paola, additional, Pradervand, Sylvain, additional, Bertuzzi, Alexia, additional, Bower, Mark, additional, Arnold, Dirk, additional, Salazar, Ramon, additional, Tucci, Marco, additional, Harrington, Kevin J, additional, Mazzoni, Francesca, additional, Mukherjee, Uma, additional, Tsourti, Zoi, additional, Michielin, Olivier, additional, Pommeret, Fanny, additional, Brunet, Joan, additional, Vincenzi, Bruno, additional, Tonini, Giuseppe, additional, Patriarca, Andrea, additional, Biello, Federica, additional, Krengli, Marco, additional, Tabernero, Josep, additional, Pentheroudakis, George, additional, Gennari, Alessandra, additional, Peters, Solange, additional, Romano, Emanuela, additional, and Pinato, David J, additional
Published: 2022
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11. Vaccination against SARS-CoV-2 protects from morbidity, mortality and sequelae from COVID19 in patients with cancer

Author: Pinato, David J., primary, Ferrante, Daniela, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Salazar, Ramon, additional, Mirallas, Oriol, additional, Sureda, Anna, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Maluquer, Clara, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, Lee, Alvin J.X., additional, Sng, Christopher C.T., additional, Liñan, Raquel, additional, Rossi, Sabrina, additional, Carmona-García, M.Carmen, additional, Sharkey, Rachel, additional, Eremiev, Simeon, additional, Rizzo, Gianpiero, additional, Bain, Hamish DC., additional, Yu, Tamara, additional, Cruz, Claudia A., additional, Perachino, Marta, additional, Saoudi-Gonzalez, Nadia, additional, Fort-Culillas, Roser, additional, Doonga, Kris, additional, Fox, Laura, additional, Roldán, Elisa, additional, Zoratto, Federica, additional, Gaidano, Gianluca, additional, Ruiz-Camps, Isabel, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Shawe-Taylor, Marianne, additional, Fusco, Vittorio, additional, Martinez-Vila, Clara, additional, Berardi, Rossana, additional, Filetti, Marco, additional, Mazzoni, Francesca, additional, Santoro, Armando, additional, Delfanti, Sara, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Prat, Aleix, additional, Tabernero, Josep, additional, Gennari, Alessandra, additional, Cortellini, Alessio, additional, Pinato, David J., additional, Evans, Joanne S., additional, Swallow, Judith, additional, Hanbury, Georgina, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Ottaviani, Diego, additional, Chowdhury, Amani, additional, Lee, Alvin JX., additional, Sng, Christopher CT., additional, Sinclair, Alasdair, additional, Cooper, Lee, additional, Rogers, Lucy, additional, Belessiotis, Katherine, additional, Murphy, Cian, additional, Bawany, Samira, additional, Khalique, Saira, additional, Andaleeb, Ramis, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Dolly, Saorise, additional, Sita-Lumsde, Ailsa, additional, Apthorp, Eleanor, additional, Jones, Eleanor, additional, Van Hemelrijck, Mieke, additional, Moss, Charlotte, additional, Russell, Beth, additional, Diamantis, Nikolaos, additional, Mukherjee, Uma, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Garcia Illescas, David, additional, Saoudi, Nadia, additional, Carmona Garcia, MCarmen, additional, Fort-Culillas, Robert, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Mesia, Ricard, additional, Felip, Eudald, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, D’Avanzo, Francesca, additional, Scotti, Lorenza, additional, Krengly, Marco, additional, Marrari, Andrea, additional, Grosso, Federica, additional, Maconi, Antonio, additional, Betti, Marta, additional, Vincenzi, Bruno, additional, Tonini, Giuseppe, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Fotia, Vittoria, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Libertini, Michela, additional, Bertulli, Rossella, additional, Provenzano, Salvatore, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Giusti, Raffaele, additional, Tucci, Marco, additional, Cantini, Luca, additional, Paoloni, Francesco, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, Pommeret, Fanny, additional, and Colomba, Emeline, additional
Published: 2022
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12. Persistence of long-term COVID-19 sequelae in patients with cancer: An analysis from the OnCovid registry

Author: Cortellini, Alessio, primary, Salazar, Ramon, additional, Gennari, Alessandra, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Maluquer, Clara, additional, Pedrazzoli, Paolo, additional, Lee, Alvin JX., additional, Carmona-García, MCarmen, additional, Newsom-Davis, Thomas, additional, Van Hemelrijck, Mieke, additional, Plaja, Andrea, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Generali, Daniele, additional, Bertulli, Rossella, additional, Diamantis, Nikolaos, additional, Mukherjee, Uma, additional, Rizzo, Gianpiero, additional, Yu, Tamara, additional, Zoratto, Federica, additional, Bruna, Riccardo, additional, Sureda, Anna, additional, Martinez-Vila, Clara, additional, Cantini, Luca, additional, Mazzoni, Francesca, additional, Grosso, Federica, additional, Parisi, Alessandro, additional, Saponara, Maristella, additional, Prat, Aleix, additional, and Pinato, David J., additional
Published: 2022
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13. Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study

Author: Pinato, David J, primary, Aguilar-Company, Juan, additional, Ferrante, Daniela, additional, Hanbury, Georgina, additional, Bower, Mark, additional, Salazar, Ramon, additional, Mirallas, Oriol, additional, Sureda, Anna, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, Mesia, Ricard, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Handford, Jasmine, additional, Sita-Lumsden, Ailsa, additional, Apthorp, Eleanor, additional, Vincenzi, Bruno, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Maluquer, Clara, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, Sinclair, Alasdair, additional, Bawany, Samira, additional, Khalique, Saira, additional, Rossi, Sabrina, additional, Rogers, Lucy, additional, Murphy, Cian, additional, Belessiotis, Katherine, additional, Carmona-García, M Carmen, additional, Sharkey, Rachel, additional, García-Illescas, David, additional, Rizzo, Gianpiero, additional, Perachino, Marta, additional, Saoudi-Gonzalez, Nadia, additional, Doonga, Kris, additional, Fox, Laura, additional, Roldán, Elisa, additional, Gaidano, Gianluca, additional, Ruiz-Camps, Isabel, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Martinez-Vila, Clara, additional, Cantini, Luca, additional, Zambelli, Alberto, additional, Giusti, Raffaele, additional, Mazzoni, Francesca, additional, Caliman, Enrico, additional, Santoro, Armando, additional, Grosso, Federica, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Prat, Aleix, additional, Tucci, Marco, additional, Libertini, Michela, additional, Grisanti, Salvatore, additional, Mukherjee, Uma, additional, Diamantis, Nikolaos, additional, Fusco, Vittorio, additional, Generali, Daniele, additional, Provenzano, Salvatore, additional, Gennari, Alessandra, additional, Tabernero, Josep, additional, Cortellini, Alessio, additional, Evans, Joanne S, additional, Swallow, Judith, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Ottaviani, Diego, additional, Chowdhury, Amani, additional, Merry, Eve, additional, Chopra, Neha, additional, Lee, Alvin JX, additional, Sng, Christopher CT, additional, Yu, Tamara, additional, Shawe-Taylor, Marianne, additional, Bain, Hamish DC, additional, Wong, Yien Ning Sophia, additional, Galazi, Myria, additional, Benafif, Sarah, additional, Dileo, Palma, additional, Earnshaw, Irina, additional, Patel, Grisma, additional, Wu, Anjui, additional, Soosaipillai, Gehan, additional, Cooper, Lee, additional, Andaleeb, Ramis, additional, Dolly, Saoirse, additional, Srikandarajah, Krishnie, additional, Jones, Eleanor, additional, Van Hemelrijck, Mieke, additional, Moss, Charlotte, additional, Russell, Beth, additional, Chester, John, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Cruz, Claudia A, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Eremiev, Simeon, additional, Fort-Culillas, Roser, additional, Garcia, Isabel, additional, Liñan, Raquel, additional, Roqué Lloveras, Ariadna, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Felip, Eudald, additional, Pous, Anna, additional, D'Avanzo, Francesca, additional, Scotti, Lorenza, additional, Krengli, Marco, additional, Marrari, Andrea, additional, Delfanti, Sara, additional, Maconi, Antonio, additional, Betti, Marta, additional, Tonini, Giuseppe, additional, Di Fazio, Giuseppina Rita, additional, Tondini, Carlo, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Bertulli, Rossella, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Filetti, Marco, additional, Zoratto, Federica, additional, Paoloni, Francesco, additional, Berardi, Rossana, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, Tagliamento, Marco, additional, Colomba, Emeline, additional, and Pommeret, Fanny, additional
Published: 2022
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14. Clinical effectiveness of SARS-CoV-2 vaccines and booster doses in patients with cancer: An analysis from the European OnCovid registry.

Author: Pinato, David J. James, primary, Aguilar-Company, Juan, additional, Ferrante, Daniela, additional, Hanbury, Georgina Helen, additional, Bower, Mark, additional, Salazar, Ramon, additional, Lambertini, Matteo, additional, Pedrazzoli, Paolo, additional, Lee, Alvin Jun Xing, additional, Sinclair, Alasdair, additional, Townsed, Sarah, additional, Plaja, Andrea, additional, Tucci, Marco, additional, Sita-Lumsden, Ailsa, additional, Mukherjee, Uma, additional, Mazzoni, Francesca, additional, Aujayeb, Avinash, additional, Gennari, Alessandra, additional, Tabernero, Josep, additional, and Cortellini, Alessio, additional
Published: 2022
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15. Persistence of long-term COVID-19 sequelae in patients with cancer:An analysis from the OnCovid registry

Author: Cortellini, Alessio, Salazar, Ramon, Gennari, Alessandra, Aguilar-Company, Juan, Bower, Mark, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Maluquer, Clara, Pedrazzoli, Paolo, Lee, Alvin JX, Carmona-García, MCarmen C., Newsom-Davis, Thomas, Van Hemelrijck, Mieke, Plaja, Andrea, Zambelli, Alberto, Tondini, Carlo, Generali, Daniele, Bertulli, Rossella, Diamantis, Nikolaos, Mukherjee, Uma, Rizzo, Gianpiero, Yu, Tamara, Zoratto, Federica, Bruna, Riccardo, Sureda, Anna, Martinez-Vila, Clara, Cantini, Luca, Mazzoni, Francesca, Grosso, Federica, Parisi, Alessandro, Saponara, Maristella, Prat, Aleix, Pinato, David J., Cortellini, Alessio, Salazar, Ramon, Gennari, Alessandra, Aguilar-Company, Juan, Bower, Mark, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Maluquer, Clara, Pedrazzoli, Paolo, Lee, Alvin JX, Carmona-García, MCarmen C., Newsom-Davis, Thomas, Van Hemelrijck, Mieke, Plaja, Andrea, Zambelli, Alberto, Tondini, Carlo, Generali, Daniele, Bertulli, Rossella, Diamantis, Nikolaos, Mukherjee, Uma, Rizzo, Gianpiero, Yu, Tamara, Zoratto, Federica, Bruna, Riccardo, Sureda, Anna, Martinez-Vila, Clara, Cantini, Luca, Mazzoni, Francesca, Grosso, Federica, Parisi, Alessandro, Saponara, Maristella, Prat, Aleix, and Pinato, David J.
Abstract: Introduction: A significant proportion of patients with cancer who recover from Coronavirus Disease 2019 (COVID-19) may experience COVID-19 sequelae in the early post-infection phase, which negatively affect their continuity of care and oncological outcome. The long-term prevalence and clinical impact of the post-COVID-19 syndrome in patients with cancer are largely unknown. Methods: In this study, we describe the time course of COVID-19 sequelae in patients with non-advanced cancers enrolled in the OnCovid registry. Results: Overall, 186 patients were included, with a median observation period of 9.9 months (95%CI:8,8–11.3) post-COVID-19 resolution. After a median interval of 2.3 months post-COVID-19 (interquartile range: 1.4–3.7), 31 patients (16.6%) reported ≥1 sequelae, including respiratory complications (14, 7.6%), fatigue (13, 7.1%), neuro-cognitive sequelae (7, 3.8%). The vast majority of the patients were not vaccinated prior to COVID-19. COVID-19-related sequelae persisted in 9.8% and 8% of patients 6 and 12 months after COVID-19 resolution. Persistence of sequelae at first oncological follow-up was associated with history of complicated COVID-19 (45.2% vs 24.8%, p = 0.0223), irrespective of oncological features at COVID-19 diagnosis. Conclusion: This study confirms for the first time that, in a largely unvaccinated population, post-COVID-19 syndrome can affect a significant proportion of patients with non-advanced cancer who recovered from the acute illness. COVID-19 sequelae may persist up to 12 months in some patients, highlighting the need for dedicated prevention and supportive strategies.
Published: 2022

16. A real-world description of pathogenic mutations and their genomic context in patients with lung adenocarcinoma in East London

Author: Mukherjee, Uma, primary, Ricketts, William, additional, Kolotia, Balwinder, additional, Lim, Louise, additional, and Januszewski, Adam, additional
Published: 2022
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17. Trichoderma: Biology and Applications

Author: Prasun K Mukherjee, Uma Shankar Singh, Benjamin A Horwitz, Monika Schmoll, Mala Mukherjee, Prasun K Mukherjee, U S Singh, B A Horwitz, Monika Schmoll, Mala Mukherjee
Published: 2013

18. Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study

Author: Pinato, David J, primary, Tabernero, Josep, additional, Bower, Mark, additional, Scotti, Lorenza, additional, Patel, Meera, additional, Colomba, Emeline, additional, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Dalla Pria, Alessia, additional, Aguilar-Company, Juan, additional, Ottaviani, Diego, additional, Chowdhury, Amani, additional, Merry, Eve, additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Tagliamento, Marco, additional, Pous, Anna, additional, Sita-Lumsden, Ailsa, additional, Srikandarajah, Krishnie, additional, Colomba, Johann, additional, Pommeret, Fanny, additional, Seguí, Elia, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Pedrazzoli, Paolo, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Moss, Charlotte, additional, Evans, Joanne S, additional, Russell, Beth, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Biello, Federica, additional, Bertulli, Rossella, additional, Liñan, Raquel, additional, Rossi, Sabrina, additional, Carmona-García, Maria Carmen, additional, Tondini, Carlo, additional, Fox, Laura, additional, Baggi, Alice, additional, Fotia, Vittoria, additional, Parisi, Alessandro, additional, Porzio, Giampero, additional, Saponara, Maristella, additional, Cruz, Claudia Andrea, additional, García-Illescas, David, additional, Felip, Eudald, additional, Roqué Lloveras, Ariadna, additional, Sharkey, Rachel, additional, Roldán, Elisa, additional, Reyes, Roxana, additional, Earnshaw, Irina, additional, Ferrante, Daniela, additional, Marco-Hernández, Javier, additional, Ruiz-Camps, Isabel, additional, Gaidano, Gianluca, additional, Patriarca, Andrea, additional, Bruna, Riccardo, additional, Sureda, Anna, additional, Martinez-Vila, Clara, additional, Sanchez de Torre, Ana, additional, Cantini, Luca, additional, Filetti, Marco, additional, Rimassa, Lorenza, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Krengli, Marco, additional, Santoro, Armando, additional, Prat, Aleix, additional, Van Hemelrijck, Mieke, additional, Diamantis, Nikolaos, additional, Newsom-Davis, Thomas, additional, Gennari, Alessandra, additional, Cortellini, Alessio, additional, Swallow, Judith, additional, Chung, Chris, additional, Dettorre, Gino, additional, Chopra, Neha, additional, Lee, Alvin JX, additional, Sng, Christopher CT, additional, Wong, Yien Ning Sophia, additional, Galazi, Myria, additional, Benafif, Sarah, additional, Dileo, Palma, additional, Patel, Grisma, additional, Wu, Anjui, additional, Sinclair, Alasdair, additional, Soosaipillai, Gehan, additional, Jones, Eleanor, additional, Jackson, Amanda, additional, Piccart, Martine, additional, Colomba-Blameble, Emeline, additional, Cruz, Claudia A, additional, Segui, Elia, additional, Garcia Illescas, David, additional, Mirallas, Oriol, additional, Carbó, Anna, additional, Garcia, Isabel, additional, Wuerstlein, Rachel, additional, Mesia, Ricard, additional, Maluquer, Clara, additional, D'Avanzo, Francesca, additional, Tonini, Giuseppe, additional, Provenzano, Salvatore, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Queirolo, Paola, additional, Giusti, Raffaele, additional, Mazzoni, Francesca, additional, Zoratto, Federica, additional, Tucci, Marco, additional, Berardi, Rossana, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, and Iglesias, Maria, additional
Published: 2021
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19. Parkinsonʼs disease proteins: Novel mitochondrial targets for cardioprotection

Author: Mukherjee, Uma A., Ong, Sang-Bing, Ong, Sang-Ging, and Hausenloy, Derek J.
Published: 2015
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20. Determinants of enhanced vulnerability to COVID-19 in UK cancer patients: a European Study

Author: Pinato, David J., Scotti, Lorenza, Gennari, Alessandra, Colomba-Blameble, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Mukherjee, Uma, Zambelli, Alberto, Aguilar-Company, Juan, Bower, Mark, Galazi, Myria, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Colomba, Johann, Pommeret, Fanny, Seguí, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S., Russell, Beth, Wuerstlein, Rachel, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Liñan, Raquel, Marrari, Andrea, Carmona-García, M. Carmen, Sng, Christopher CT., Tondini, Carlo, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia Andrea, Saoudi-Gonzalez, Nadia, Felip, Eudald, Roqué Lloveras, Ariadna, Lee, Alvin J.X., Newsom-Davis, Thomas, Sharkey, Rachel, Chung, Chris, García-Illescas, David, Reyes, Roxana, Sophia Wong, Yien Ning, Ferrante, Daniela, Marco-Hernández, Javier, Ruiz-Camps, Isabel, Gaidano, Gianluca, Patriarca, Andrea, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Prat, Aleix, Tabernero, Josep, Van Hemelrijck, Mieke, Diamantis, Nikolaos, and Cortellini, Alessio
Subjects: Europe, SARS-CoV-2, COVID-19, cancer, UK, Mortality, Original Research
Abstract: Background Despite high contagiousness and rapid spread, SARS-CoV-2 has led to heterogeneous outcomes across affected nations. Within Europe, the United Kingdom (UK) is the most severely affected country, with a death toll in excess of 100.000 as of January 2021. We aimed to compare the national impact of COVID-19 on the risk of death in UK cancer patients versus those in continental Europe (EU). Methods We performed a retrospective analysis of the OnCovid study database, a European registry of cancer patients consecutively diagnosed with COVID-19 in 27 centres from February 27 to September 10, 2020. We analysed case fatality rates and risk of death at 30 days and 6 months stratified by region of origin (UK versus EU). We compared patient characteristics at baseline, including oncological and COVID-19 specific therapy across UK and EU cohorts and evaluated the association of these factors with the risk adverse outcome in multivariable Cox regression models. Findings Compared to EU (n=924), UK patients (n=468) were characterised by higher case fatality rates (40.38% versus 26.5%, p
Published: 2021

21. Abstract 701: The acute phase response identifies cancer patients with adverse outcomes from SARS-CoV-2 infection as quantified by the OnCovid Inflammatory Score

Author: Dettorre, Gino M., primary, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher C., additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Seeva, Pavetha, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Moss, Charlotte, additional, Tabernero, Josep, additional, Russell, Beth, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Liñan, Raquel, additional, Marrari, Andrea, additional, Carmona-García, M. Carmen, additional, Chopra, Neha, additional, Tondini, Carlo, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Fotia, Vittoria, additional, Cruz, Claudia Andrea, additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, Roqué, Ariadna, additional, Lee, Alvin J., additional, Newsom-Davis, Thomas, additional, Patriarca, Andrea, additional, Rimassa, Lorenza, additional, Santoro, Armando, additional, Gennari, Alessandra, additional, Diamantis, Nikolaos, additional, and Pinato, David J., additional
Published: 2021
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22. Determinants of enhanced vulnerability to coronavirus disease 2019 in UK patients with cancer: a European study

Author: Pinato, David J., primary, Scotti, Lorenza, additional, Gennari, Alessandra, additional, Colomba-Blameble, Emeline, additional, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Galazi, Myria, additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Sita-Lumsden, Ailsa, additional, Colomba, Johann, additional, Pommeret, Fanny, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Moss, Charlotte, additional, Evans, Joanne S., additional, Russell, Beth, additional, Wuerstlein, Rachel, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Liñan, Raquel, additional, Marrari, Andrea, additional, Carmona-García, M.C., additional, Sng, Christopher. C.T., additional, Tondini, Carlo, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Fotia, Vittoria, additional, Cruz, Claudia A., additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, R. Lloveras, Ariadna, additional, Lee, Alvin. J.X., additional, Newsom-Davis, Thomas, additional, Sharkey, Rachel, additional, Chung, Chris, additional, García-Illescas, David, additional, Reyes, Roxana, additional, Sophia Wong, Yien N., additional, Ferrante, Daniela, additional, Marco-Hernández, Javier, additional, Ruiz-Camps, Isabel, additional, Gaidano, Gianluca, additional, Patriarca, Andrea, additional, Sureda, Anna, additional, Martinez-Vila, Clara, additional, Sanchez de Torre, Ana, additional, Rimassa, Lorenza, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Krengli, Marco, additional, Santoro, Armando, additional, Prat, Aleix, additional, Tabernero, Josep, additional, V. Hemelrijck, Mieke, additional, Diamantis, Nikolaos, additional, and Cortellini, Alessio, additional
Published: 2021
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23. sj-docx-1-tam-10.1177_17588359211053416 �� Supplemental material for COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry

Author: Garrig��s, Laia, Saura, Cristina, Martinez-Vila, Clara, Zambelli, Alberto, Bower, Mark, Pistilli, Barbara, Lambertini, Matteo, Ottaviani, Diego, Diamantis, Nikolaos, Lumsden, Ailsa, Pernas, Sonia, Generali, Daniele, Segu��, Elia, Vi��as, Gemma, Felip, Eudald, Sanchez, Ana, Rizzo, Gianpiero, Santoro, Armando, Cortellini, Alessio, Perone, Ylenia, Chester, John, Iglesias, Maria, Betti, Marta, Vincenzi, Bruno, Libertini, Michela, Mazzoni, Francesca, Zoratto, Federica, Berardi, Rossana, Guida, Annalisa, Wuerstlein, Rachel, Loizidou, Angela, Sharkey, Rachel, Aguilar Company, Juan, Matas, Marta, Saggia, Chiara, Chiudinelli, Lorenzo, Colomba-Blameble, Emeline, Galazi, Myria, Mukherjee, Uma, Van Hemelrijck, Mieke, Marin, Mar, Strina, Carla, Prat, Aleix, Pla, Helena, Ciruelos, Eva Maria, Bertuzzi, Alexia, del Mastro, Lucia, Porzio, Giampiero, Newsom-Davis, Thomas, Ruiz, Isabel, Delany, Maria Belen, Krengli, Marco, Fotia, Vittoria, Viansone, Alessandro, Chopra, Neha, Romeo, Margarita, Salazar, Ramon, Perez, Ignacio, d��Avanzo, Francesca, Franchi, Michela, Milani, Manuela, Pommeret, Fanny, Tucci, Marco, Pedrazzoli, Paolo, Harbeck, Nadia, Ferrante, Daniela, Pinato, David J., and Gennari, Alessandra
Subjects: 110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract: Supplemental material, sj-docx-1-tam-10.1177_17588359211053416 for COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry by Laia Garrig��s, Cristina Saura, Clara Martinez-Vila, Alberto Zambelli, Mark Bower, Barbara Pistilli, Matteo Lambertini, Diego Ottaviani, Nikolaos Diamantis, Ailsa Lumsden, Sonia Pernas, Daniele Generali, Elia Segu��, Gemma Vi��as, Eudald Felip, Ana Sanchez, Gianpiero Rizzo, Armando Santoro, Alessio Cortellini, Ylenia Perone, John Chester, Maria Iglesias, Marta Betti, Bruno Vincenzi, Michela Libertini, Francesca Mazzoni, Federica Zoratto, Rossana Berardi, Annalisa Guida, Rachel Wuerstlein, Angela Loizidou, Rachel Sharkey, Juan Aguilar Company, Marta Matas, Chiara Saggia, Lorenzo Chiudinelli, Emeline Colomba-Blameble, Myria Galazi, Uma Mukherjee, Mieke Van Hemelrijck, Mar Marin, Carla Strina, Aleix Prat, Helena Pla, Eva Maria Ciruelos, Alexia Bertuzzi, Lucia del Mastro, Giampiero Porzio, Thomas Newsom-Davis, Isabel Ruiz, Maria Belen Delany, Marco Krengli, Vittoria Fotia, Alessandro Viansone, Neha Chopra, Margarita Romeo, Ramon Salazar, Ignacio Perez, Francesca d��Avanzo, Michela Franchi, Manuela Milani, Fanny Pommeret, Marco Tucci, Paolo Pedrazzoli, Nadia Harbeck, Daniela Ferrante, David J. Pinato and Alessandra Gennari in Therapeutic Advances in Medical Oncology
Published: 2021
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24. Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score

Author: Dettorre, Gino M., Dolly, Saoirse, Loizidou, Angela, Chester, John, Jackson, Amanda, Mukherjee, Uma, Zambelli, Alberto, Aguilar Company, Juan, Bower, Mark, Sng, Christopher C. T., Salazar Soler, Ramón, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Seguí, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Seeva, Pavetha, Rizzo, Gianpiero, Libertini, Michela, Maconi, Antonio, Moss, Charlotte, Russell, Beth, Harbeck, Nadia, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Liñan, Raquel, Marrari, Andrea, Carmona García, M. Carmen, Chopra, Neha, Tondini, Carlo Alberto, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia Andrea, Saoudi González, Nadia, Felip, Eudald, Roqué, Ariadna, Lee, Alvin J. X., Newsom-Davis, Tom, García Illescas, David, Reyes, Roxana, Wong, Yien Ning Sophia, Ferrante, Daniela, Scotti, Lorenza, Marco Hernández, Javier, Ruiz Camps, Isabel, Patriarca, Andrea, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Santoro, Armando, Prat Aparicio, Aleix, Gennari, Alessandra, Van Hemelrijck, Mieke, Tabernero Caturla, Josep, Diamantis, Nikolaos, Pinato, David J., OnCovid study group, Dettorre, G. M., Dolly, S., Loizidou, A., Chester, J., Jackson, A., Mukherjee, U., Zambelli, A., Aguilar-Company, J., Bower, M., Sng, C. C. T., Salazar, R., Bertuzzi, A., Brunet, J., Mesia, R., Sita-Lumsden, A., Segui, E., Biello, F., Generali, D., Grisanti, S., Seeva, P., Rizzo, G., Libertini, M., Maconi, A., Moss, C., Russell, B., Harbeck, N., Vincenzi, B., Bertulli, R., Ottaviani, D., Linan, R., Marrari, A., Carmen Carmona-Garcia, M., Chopra, N., Tondini, C. A., Mirallas, O., Tovazzi, V., Fotia, V., Cruz, C. A., Saoudi-Gonzalez, N., Felip, E., Roque, A., Lee, A. J. X., Newsom-Davis, T., Garcia-Illescas, D., Reyes, R., Wong, Y. N. S., Ferrante, D., Scotti, L., Marco-Hernandez, J., Ruiz-Camps, I., Patriarca, A., Rimassa, L., Chiudinelli, L., Franchi, M., Santoro, A., Prat, A., Gennari, A., Van Hemelrijck, M., Tabernero, J., Diamantis, N., Pinato, D. J., Wellcome Trust, Institut Català de la Salut, [Dettorre GM] Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, UK. [Dolly S] Medical Oncology, Guy’s and St Thomas’ NHS Foundation Trust (GSTT), London, UK. [Loizidou A] Department of Infectious Diseases, Internal Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. [Chester J] Medical Oncology, School of Medicine, Cardiff University, Cardiff, UK. Medical Oncology, Velindre Cancer Centre, Cardiff, UK. [Jackson A] Clinical Trials, Velindre Cancer Centre, Cardiff, UK. [Mukherjee U] Medical Oncology, Barts Health NHS Trust, London, UK. [Aguilar-Company J] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Mirallas O, Saoudi-Gonzalez N, García-Illescas D] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Ruiz-Camps I] Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Tabernero J] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. IOB-Quiron, UVic-UCC, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Male, 0301 basic medicine, Oncology, Cancer Research, Comorbidity, Systemic inflammation, Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores], COVID-19 Testing, 0302 clinical medicine, Neoplasms, Immunotherapy Biomarkers, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], 80 and over, Immunology and Allergy, Medicine, Hypoalbuminemia, Young adult, Càncer, Multivariate Analysi, RC254-282, COVID-19 (Malaltia) - Complicacions, Cancer, Aged, 80 and over, OnCovid study group, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Middle Aged, Prognosis, Inflamació, Systemic Inflammatory Response Syndrome, 030220 oncology & carcinogenesis, Cohort, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation::Systemic Inflammatory Response Syndrome [DISEASES], Molecular Medicine, Female, medicine.symptom, Life Sciences & Biomedicine, Human, Adult, medicine.medical_specialty, Prognosi, Càncer - Epidemiologia, Immunology, neoplasias [ENFERMEDADES], inflammation mediator, Young Adult, 03 medical and health sciences, Internal medicine, Humans, afecciones patológicas, signos y síntomas::procesos patológicos::inflamación::síndrome de respuesta inflamatoria sistémica [ENFERMEDADES], Aged, Pharmacology, Science & Technology, business.industry, SARS-CoV-2, COVID-19, medicine.disease, inflammation, inflammation mediators, Blood Cell Count, Multivariate Analysis, Neoplasms [DISEASES], Systemic inflammatory response syndrome, 030104 developmental biology, Neoplasm, Lymphocytopenia, business, Other subheadings::Other subheadings::/complications [Other subheadings]
Abstract: Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflamació; Mediadors d'inflamació Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflamación; Mediadores de la inflamación Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflammation; Inflammation mediators Background Patients with cancer are particularly susceptible to SARS-CoV-2 infection. The systemic inflammatory response is a pathogenic mechanism shared by cancer progression and COVID-19. We investigated systemic inflammation as a driver of severity and mortality from COVID-19, evaluating the prognostic role of commonly used inflammatory indices in SARS-CoV-2-infected patients with cancer accrued to the OnCovid study. Methods In a multicenter cohort of SARS-CoV-2-infected patients with cancer in Europe, we evaluated dynamic changes in neutrophil:lymphocyte ratio (NLR); platelet:lymphocyte ratio (PLR); Prognostic Nutritional Index (PNI), renamed the OnCovid Inflammatory Score (OIS); modified Glasgow Prognostic Score (mGPS); and Prognostic Index (PI) in relation to oncological and COVID-19 infection features, testing their prognostic potential in independent training (n=529) and validation (n=542) sets. Results We evaluated 1071 eligible patients, of which 625 (58.3%) were men, and 420 were patients with malignancy in advanced stage (39.2%), most commonly genitourinary (n=216, 20.2%). 844 (78.8%) had ≥1 comorbidity and 754 (70.4%) had ≥1 COVID-19 complication. NLR, OIS, and mGPS worsened at COVID-19 diagnosis compared with pre-COVID-19 measurement (p
Published: 2021

25. COVID-19 Sequelae and the Host Proinflammatory Response: An Analysis From the OnCovid Registry.

Author: Cortellini, Alessio, Gennari, Alessandra, Pommeret, Fanny, Patel, Grisma, Newsom-Davis, Thomas, Bertuzzi, Alexia, Viladot, Margarita, Aguilar-Company, Juan, Mirallas, Oriol, Felip, Eudald, Lee, Alvin J X, Pria, Alessia Dalla, Sharkey, Rachel, Brunet, Joan, Carmona-García, MCarmen, Chester, John, Mukherjee, Uma, Scotti, Lorenza, Dolly, Saoirse, and Sita-Lumsden, Ailsa
Abstract: Background: Fifteen percent of patients with cancer experience symptomatic sequelae, which impair post-COVID-19 outcomes. In this study, we investigated whether a proinflammatory status is associated with the development of COVID-19 sequelae.Methods: OnCovid recruited 2795 consecutive patients who were diagnosed with Severe Acute Respiratory Syndrome Coronavirus 2 infection between February 27, 2020, and February 14, 2021. This analysis focused on COVID-19 survivors who underwent a clinical reassessment after the exclusion of patients with hematological malignancies. We evaluated the association of inflammatory markers collected at COVID-19 diagnosis with sequelae, considering the impact of previous systemic anticancer therapy. All statistical tests were 2-sided.Results: Of 1339 eligible patients, 203 experienced at least 1 sequela (15.2%). Median baseline C-reactive protein (CRP; 77.5 mg/L vs 22.2 mg/L, P < .001), lactate dehydrogenase (310 UI/L vs 274 UI/L, P = .03), and the neutrophil to lymphocyte ratio (NLR; 6.0 vs 4.3, P = .001) were statistically significantly higher among patients who experienced sequelae, whereas no association was reported for the platelet to lymphocyte ratio and the OnCovid Inflammatory Score, which includes albumin and lymphocytes. The widest area under the ROC curve (AUC) was reported for baseline CRP (AUC = 0.66, 95% confidence interval [CI]: 0.63 to 0.69), followed by the NLR (AUC = 0.58, 95% CI: 0.55 to 0.61) and lactate dehydrogenase (AUC = 0.57, 95% CI: 0.52 to 0.61). Using a fixed categorical multivariable analysis, high CRP (odds ratio [OR] = 2.56, 95% CI: 1.67 to 3.91) and NLR (OR = 1.45, 95% CI: 1.01 to 2.10) were confirmed to be statistically significantly associated with an increased risk of sequelae. Exposure to chemotherapy was associated with a decreased risk of sequelae (OR = 0.57, 95% CI: 0.36 to 0.91), whereas no associations with immune checkpoint inhibitors, endocrine therapy, and other types of systemic anticancer therapy were found.Conclusions: Although the association between inflammatory status, recent chemotherapy and sequelae warrants further investigation, our findings suggest that a deranged proinflammatory reaction at COVID-19 diagnosis may predict for sequelae development. [ABSTRACT FROM AUTHOR]
Published: 2022
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26. Abstract S01-03: The acute phase response identifies cancer patients with adverse outcomes from SARS-CoV-2 infection as quantified by the OnCovid Inflammatory Score

Author: Dettorre, Gino M., primary, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher C. T., additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Seeva, Pavetha, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Moss, Charlotte, additional, Russell, Beth, additional, Tabernero, Josep, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Marrari, Andrea, additional, Carmona-García, M. Carmen, additional, Chopra, Neha, additional, Tondini, Carlo, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Fotia, Vittoria, additional, Cruz, Claudia A., additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, Scotti, Lorenza, additional, Lee, Alvin J. X., additional, Newsom-Davis, Thomas, additional, Patriarca, Andrea, additional, Rimassa, Lorenza, additional, Santoro, Armando, additional, Gennari, Alessandra, additional, Van Hemelrijck, Mieke, additional, Diamantis, Nikolaos, additional, and Pinato, David J., additional
Published: 2021
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27. Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score

Author: Dettorre, Gino M, primary, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher C T, additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Seeva, Pavetha, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Moss, Charlotte, additional, Russell, Beth, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Liñan, Raquel, additional, Marrari, Andrea, additional, Carmona-García, M Carmen, additional, Chopra, Neha, additional, Tondini, Carlo Alberto, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Fotia, Vittoria, additional, Cruz, Claudia Andrea, additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, Roqué, Ariadna, additional, Lee, Alvin J X, additional, Newsom-Davis, Tom, additional, García-Illescas, David, additional, Reyes, Roxana, additional, Wong, Yien Ning Sophia, additional, Ferrante, Daniela, additional, Scotti, Lorenza, additional, Marco-Hernández, Javier, additional, Ruiz-Camps, Isabel, additional, Patriarca, Andrea, additional, Rimassa, Lorenza, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Santoro, Armando, additional, Prat, Aleix, additional, Gennari, Alessandra, additional, Van Hemelrijck, Mieke, additional, Tabernero, Josep, additional, Diamantis, Nikolaos, additional, and Pinato, David J, additional
Published: 2021
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28. Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective

Author: Soosaipillai, Gehan, primary, Wu, Anjui, additional, Dettorre, Gino M, additional, Diamantis, Nikolaos, additional, Chester, John, additional, Moss, Charlotte, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher CT, additional, Salazar, Ramon, additional, Brunet, Joan, additional, Jones, Eleanor, additional, Mesia, Ricard, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Ottaviani, Diego, additional, Carbó, Anna, additional, Benafif, Sarah, additional, Würstlein, Rachel, additional, Carmona, Carme, additional, Chopra, Neha, additional, Cruz, Claudia Andrea, additional, Swallow, Judith, additional, Saoudi, Nadia, additional, Felip, Eudald, additional, Galazi, Myria, additional, Garcia-Fructuoso, Isabel, additional, Lee, Alvin J. X., additional, Newsom-Davis, Thomas, additional, Wong, Yien Ning Sophia, additional, Sureda, Anna, additional, Maluquer, Clara, additional, Ruiz-Camps, Isabel, additional, Cabirta, Alba, additional, Prat, Aleix, additional, Loizidou, Angela, additional, Gennari, Alessandra, additional, Ferrante, Daniela, additional, Tabernero, Josep, additional, Russell, Beth, additional, Van Hemelrijck, Mieke, additional, Dolly, Saoirse, additional, Hulbert-Williams, Nicholas J, additional, Pinato, David J, additional, Mollà, Meritxell, additional, Reyes, Roxana, additional, Marco-Hernández, Javier, additional, Bruna, Riccardo, additional, Biello, Federica, additional, Patriarca, Andrea, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Fotia, Vittoria, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Tovazzi, Valeria, additional, Bertuzzi, Alexia, additional, Marrari, Andrea, additional, Seeva, Pavetha, additional, Dileo, Palma, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Betti, Marta, additional, Provenzano, Salvatore, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Liñan, Raquel, additional, Roqué, Ariadna, additional, Mirallas, Oriol, additional, García-Illescas, David, additional, Scotti, Lorenza, additional, Dalla Pria, Alessia, additional, D’Avanzo, Francesca, additional, Martinez, Maria, additional, Evans, Joanne S, additional, Sharkey, Rachel, additional, Rimassa, Lorenza, additional, Santoro, Armando, additional, Gaidano, Gianluca, additional, and Izuzquiza, Macarena, additional
Published: 2021
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29. COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry

Author: Garrigós, Laia, primary, Saura, Cristina, additional, Martinez-Vila, Clara, additional, Zambelli, Alberto, additional, Bower, Mark, additional, Pistilli, Barbara, additional, Lambertini, Matteo, additional, Ottaviani, Diego, additional, Diamantis, Nikolaos, additional, Lumsden, Ailsa, additional, Pernas, Sonia, additional, Generali, Daniele, additional, Seguí, Elia, additional, Viñas, Gemma, additional, Felip, Eudald, additional, Sanchez, Ana, additional, Rizzo, Gianpiero, additional, Santoro, Armando, additional, Cortellini, Alessio, additional, Perone, Ylenia, additional, Chester, John, additional, Iglesias, Maria, additional, Betti, Marta, additional, Vincenzi, Bruno, additional, Libertini, Michela, additional, Mazzoni, Francesca, additional, Zoratto, Federica, additional, Berardi, Rossana, additional, Guida, Annalisa, additional, Wuerstlein, Rachel, additional, Loizidou, Angela, additional, Sharkey, Rachel, additional, Aguilar Company, Juan, additional, Matas, Marta, additional, Saggia, Chiara, additional, Chiudinelli, Lorenzo, additional, Colomba-Blameble, Emeline, additional, Galazi, Myria, additional, Mukherjee, Uma, additional, Van Hemelrijck, Mieke, additional, Marin, Mar, additional, Strina, Carla, additional, Prat, Aleix, additional, Pla, Helena, additional, Ciruelos, Eva Maria, additional, Bertuzzi, Alexia, additional, del Mastro, Lucia, additional, Porzio, Giampiero, additional, Newsom-Davis, Thomas, additional, Ruiz, Isabel, additional, Delany, Maria Belen, additional, Krengli, Marco, additional, Fotia, Vittoria, additional, Viansone, Alessandro, additional, Chopra, Neha, additional, Romeo, Margarita, additional, Salazar, Ramon, additional, Perez, Ignacio, additional, d’Avanzo, Francesca, additional, Franchi, Michela, additional, Milani, Manuela, additional, Pommeret, Fanny, additional, Tucci, Marco, additional, Pedrazzoli, Paolo, additional, Harbeck, Nadia, additional, Ferrante, Daniela, additional, Pinato, David J., additional, and Gennari, Alessandra, additional
Published: 2021
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30. Time-Dependent COVID-19 Mortality in Patients With Cancer: An Updated Analysis of the OnCovid Registry.

Author: Pinato, David J., Patel, Meera, Scotti, Lorenza, Colomba, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Mukherjee, Uma, Zambelli, Alberto, Dalla Pria, Alessia, Aguilar-Company, Juan, Bower, Mark, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Tagliamento, Marco, Pous, Anna, Sita-Lumsden, Ailsa, and Srikandarajah, Krishnie
Published: 2022
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31. 74 - A real-world description of pathogenic mutations and their genomic context in patients with lung adenocarcinoma in East London

Author: Mukherjee, Uma, Ricketts, William, Kolotia, Balwinder, Lim, Louise, and Januszewski, Adam
Published: 2022
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32. Final results from TACTI-002 Part C: A phase II study of eftilagimod alpha (soluble LAG-3 protein) and pembrolizumab in patients with metastatic 2nd line head and neck squamous cell carcinoma unselected for PD-L1.

Author: Doger de Spéville, Bernard, Felip, Enriqueta, Forster, Martin, Majem, Margarita, Bajaj, Pawan, Peguero, Julio Antonio, Carcereny, Enric, Krebs, Matthew G, Mukherjee, Uma, Mueller, Christian, and Triebel, Frederic
Published: 2023
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33. An improved approximation for the bounds-states of the static screened Coulomb potential

Author: Dutt, Ranabir and Mukherjee, Uma
Published: 1981
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34. Correction: Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

Author: Siddall, Hilary K., primary, Yellon, Derek M., additional, Ong, Sang-Bing, additional, Mukherjee, Uma A., additional, Burke, Niall, additional, Hall, Andrew R., additional, Angelova, Plamena R., additional, Ludtmann, Marthe H. R., additional, Deas, Emma, additional, Davidson, Sean M., additional, Mocanu, Mihaela M., additional, and Hausenloy, Derek J., additional
Published: 2013
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35. Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

Author: Siddall, Hilary K., primary, Yellon, Derek M., additional, Ong, Sang-Bing, additional, Mukherjee, Uma A., additional, Burke, Niall, additional, Hall, Andrew R., additional, Angelova, Plamena R., additional, Ludtmann, Marthe H. R., additional, Deas, Emma, additional, Davidson, Sean M., additional, Mocanu, Mihaela M., additional, and Hausenloy, Derek J., additional
Published: 2013
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36. An improved approximation for the bound s-states of the static screened Coulomb potential.

Author: Dutt, Ranabir and Mukherjee, Uma
Abstract: We propose an ansatz to revise the Ecker-Weizel approximation (EWA) method for obtaining the bound s-state energies E of the static screened Coulomb potential. The modified prescription is shown to yield substantial improvement of the values of E in comparison with the results obtained by Lam and Varshni using conventional EWA scheme. [ABSTRACT FROM AUTHOR]
Published: 1981
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37. The acute phase response identifies cancer patients with adverse outcomes from SARS-CoV-2 infection as quantified by the OnCovid Inflammatory Score

Author: Dettorre, Gino M., Dolly, Saoirse, Loizidou, Angela, Chester, John, Jackson, Amanda, Mukherjee, Uma, Zambelli, Alberto, Aguilar-Company, Juan, Bower, Mark, Sng, Christopher C. T., Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Segui, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Seeva, Pavetha, Rizzo, Gianpiero, Libertini, Michela, Maconi, Antonio, Moss, Charlotte, Russell, Beth, Tabernero, Josep, Harbeck, Nadia, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Marrari, Andrea, Carmona-Garcia, M. Carmen, Chopra, Neha, Tondini, Carlo, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia A., Saoudi-Gonzalez, Nadia, Felip, Eudald, Scotti, Lorenza, Alvin Lee, Newsom-Davis, Thomas, Patriarca, Andrea, Rimassa, Lorenza, Santoro, Armando, Gennari, Alessandra, Hemelrijck, Mieke, Diamantis, Nikolaos, and Pinato, David J.

38. sj-docx-1-tam-10.1177_17588359211042224 – Supplemental material for Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective

Author: Soosaipillai, Gehan, Wu, Anjui, Dettorre, Gino M, Diamantis, Nikolaos, Chester, John, Moss, Charlotte, Aguilar-Company, Juan, Bower, Mark, Sng, Christopher CT, Salazar, Ramon, Brunet, Joan, Jones, Eleanor, Mesia, Ricard, Jackson, Amanda, Mukherjee, Uma, Sita-Lumsden, Ailsa, Seguí, Elia, Ottaviani, Diego, Carbó, Anna, Benafif, Sarah, Würstlein, Rachel, Carmona, Carme, Chopra, Neha, Cruz, Claudia Andrea, Swallow, Judith, Saoudi, Nadia, Felip, Eudald, Galazi, Myria, Garcia-Fructuoso, Isabel, Lee, Alvin J. X., Newsom-Davis, Thomas, Wong, Yien Ning Sophia, Sureda, Anna, Maluquer, Clara, Ruiz-Camps, Isabel, Cabirta, Alba, Prat, Aleix, Loizidou, Angela, Gennari, Alessandra, Ferrante, Daniela, Tabernero, Josep, Russell, Beth, Van Hemelrijck, Mieke, Dolly, Saoirse, Hulbert-Williams, Nicholas J, and Pinato, David J
Subjects: 110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 3. Good health, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract: Supplemental material, sj-docx-1-tam-10.1177_17588359211042224 for Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective by Gehan Soosaipillai, Anjui Wu, Gino M Dettorre, Nikolaos Diamantis, John Chester, Charlotte Moss, Juan Aguilar-Company, Mark Bower, Christopher CT Sng, Ramon Salazar, Joan Brunet, Eleanor Jones, Ricard Mesia, Amanda Jackson, Uma Mukherjee, Ailsa Sita-Lumsden, Elia Seguí, Diego Ottaviani, Anna Carbó, Sarah Benafif, Rachel Würstlein, Carme Carmona, Neha Chopra, Claudia Andrea Cruz, Judith Swallow, Nadia Saoudi, Eudald Felip, Myria Galazi, Isabel Garcia-Fructuoso, Alvin J. X. Lee, Thomas Newsom-Davis, Yien Ning Sophia Wong, Anna Sureda, Clara Maluquer, Isabel Ruiz-Camps, Alba Cabirta, Aleix Prat, Angela Loizidou, Alessandra Gennari, Daniela Ferrante, Josep Tabernero, Beth Russell, Mieke Van Hemelrijck, Saoirse Dolly, Nicholas J Hulbert-Williams, David J Pinato in Therapeutic Advances in Medical Oncology

39. sj-docx-1-tam-10.1177_17588359211042224 – Supplemental material for Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective

Author: Soosaipillai, Gehan, Wu, Anjui, Dettorre, Gino M, Diamantis, Nikolaos, Chester, John, Moss, Charlotte, Aguilar-Company, Juan, Bower, Mark, Sng, Christopher CT, Salazar, Ramon, Brunet, Joan, Jones, Eleanor, Mesia, Ricard, Jackson, Amanda, Mukherjee, Uma, Sita-Lumsden, Ailsa, Seguí, Elia, Ottaviani, Diego, Carbó, Anna, Benafif, Sarah, Würstlein, Rachel, Carmona, Carme, Chopra, Neha, Cruz, Claudia Andrea, Swallow, Judith, Saoudi, Nadia, Felip, Eudald, Galazi, Myria, Garcia-Fructuoso, Isabel, Lee, Alvin J. X., Newsom-Davis, Thomas, Wong, Yien Ning Sophia, Sureda, Anna, Maluquer, Clara, Ruiz-Camps, Isabel, Cabirta, Alba, Prat, Aleix, Loizidou, Angela, Gennari, Alessandra, Ferrante, Daniela, Tabernero, Josep, Russell, Beth, Van Hemelrijck, Mieke, Dolly, Saoirse, Hulbert-Williams, Nicholas J, and Pinato, David J
Subjects: 110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 3. Good health, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract: Supplemental material, sj-docx-1-tam-10.1177_17588359211042224 for Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective by Gehan Soosaipillai, Anjui Wu, Gino M Dettorre, Nikolaos Diamantis, John Chester, Charlotte Moss, Juan Aguilar-Company, Mark Bower, Christopher CT Sng, Ramon Salazar, Joan Brunet, Eleanor Jones, Ricard Mesia, Amanda Jackson, Uma Mukherjee, Ailsa Sita-Lumsden, Elia Seguí, Diego Ottaviani, Anna Carbó, Sarah Benafif, Rachel Würstlein, Carme Carmona, Neha Chopra, Claudia Andrea Cruz, Judith Swallow, Nadia Saoudi, Eudald Felip, Myria Galazi, Isabel Garcia-Fructuoso, Alvin J. X. Lee, Thomas Newsom-Davis, Yien Ning Sophia Wong, Anna Sureda, Clara Maluquer, Isabel Ruiz-Camps, Alba Cabirta, Aleix Prat, Angela Loizidou, Alessandra Gennari, Daniela Ferrante, Josep Tabernero, Beth Russell, Mieke Van Hemelrijck, Saoirse Dolly, Nicholas J Hulbert-Williams, David J Pinato in Therapeutic Advances in Medical Oncology

40. A Case for Diagnosis

Author: Mukherjee, Uma Pada
Subjects: Correspondence
Published: 1929

41. Determinants of enhanced vulnerability to coronavirus disease 2019 in UK patients with cancer: a European study

Author: Elia Seguí, Nadia Saoudi-Gonzalez, Federica Biello, Rachel Wuerstlein, Andrea Marrari, Carlo Tondini, Ramon Salazar, Lorenza Rimassa, Claudia Andrea Cruz, Nikolaos Diamantis, David J. Pinato, Armando Santoro, Salvatore Grisanti, Clara Martinez-Vila, Charlotte Moss, Lorenzo Chiudinelli, Daniele Generali, M. C. Carmona-Garcia, Vittoria Fotia, Alexia Bertuzzi, Ailsa Sita-Lumsden, Angela Loizidou, Christopher C T Sng, Bruno Vincenzi, Alessandra Gennari, Aleix Prat, David García-Illescas, Chris Chung, Fanny Pommeret, Diego Ottaviani, Daniela Ferrante, Ariadna Roqué Lloveras, Joan Brunet, Johann Colomba, Joanne Evans, Uma Mukherjee, Alvin J.X. Lee, Juan Aguilar-Company, Andrea Patriarca, Myria Galazi, Gianluca Gaidano, Javier Marco-Hernández, Eudald Felip, Marco Krengli, Gianpiero Rizzo, Isabel Ruiz-Camps, Thomas Newsom-Davis, Mark Bower, John D. Chester, Saoirse Dolly, Yien N. Sophia Wong, Ricard Mesia, Michela Franchi, Michela Libertini, Alessio Cortellini, Roxana Reyes, Lorenza Scotti, Josep Tabernero, Rossella Bertulli, Oriol Mirallas, Valeria Tovazzi, Emeline Colomba-Blameble, Anna Sureda, Beth Russell, Raquel Liñan, Rachel Sharkey, Mieke Van Hemelrijck, Alberto Zambelli, Ana Sanchez de Torre, Pinato, David J., Scotti, Lorenza, Gennari, Alessandra, Colomba-Blameble, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Mukherjee, Uma, Zambelli, Alberto, Aguilar-Company, Juan, Bower, Mark, Galazi, Myria, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Colomba, Johann, Pommeret, Fanny, Seguí, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S., Russell, Beth, Wuerstlein, Rachel, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Liñan, Raquel, Marrari, Andrea, Carmona-García, M. C., Sng, Christopher. C. T., Tondini, Carlo, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia A., Saoudi-Gonzalez, Nadia, Felip, Eudald, R. Lloveras, Ariadna, Lee, Alvin. J. X., Newsom-Davis, Thoma, Sharkey, Rachel, Chung, Chri, García-Illescas, David, Reyes, Roxana, Sophia Wong, Yien N., Ferrante, Daniela, Marco-Hernández, Javier, Ruiz-Camps, Isabel, Gaidano, Gianluca, Patriarca, Andrea, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Prat, Aleix, Tabernero, Josep, V. Hemelrijck, Mieke, Diamantis, Nikolao, and Cortellini, Alessio
Subjects: 0301 basic medicine, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Epidemiology, Case fatality rate, medicine, COVID-19, Cancer, Europe, Mortality, SARS-CoV-2, UK, Mechanical ventilation, business.industry, Proportional hazards model, medicine.disease, Comorbidity, Confidence interval, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cohort, business
Abstract: Background: Despite high contagiousness and rapid spread, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to heterogeneous outcomes across affected nations. Within Europe (EU), the United Kingdom (UK) is the most severely affected country, with a death toll in excess of 100,000 as of January 2021. We aimed to compare the national impact of coronavirus disease 2019 (COVID-19) on the risk of death in UK patients with cancer versus those in continental EU. Methods: We performed a retrospective analysis of the OnCovid study database, a European registry of patients with cancer consecutively diagnosed with COVID-19 in 27 centres from 27th February to 10th September 2020. We analysed case fatality rates and risk of death at 30 days and 6 months stratified by region of origin (UK versus EU). We compared patient characteristics at baseline including oncological and COVID-19-specific therapy across UKand EU cohorts and evaluated the association of these factors with the risk of adverse out-comes in multivariable Cox regression models Findings: Compared with EU (n = 924), UK patients (n = 468) were characterised by higher case fatality rates (40.38% versus 26.5%, p < 0.0001) and higher risk of death at 30 days (haz-ard ratio [HR], 1.64 [95% confidence interval {CI}, 1.36-1.99]) and 6 months after COVID-19 diagnosis (47.64% versus 33.33%; p < 0.0001; HR, 1.59 [95% CI, 1.33-1.88]). UK patients were more often men, were of older age and have more comorbidities than EU counterparts (p < 0.01). Receipt of anticancer therapy was lower in UK than in EU patients (p < 0.001). Despite equal proportions of complicated COVID-19, rates of intensive care admission and use of mechanical ventilation, UK patients with cancer were less likely to receive anti-COVID-19 therapies including corticosteroids, antivirals and inter leukin-6 antagonists (p < 0.0001). Multivariable analyses adjusted for imbalanced prognostic factors confirmed the UK cohort to be characterised by worse risk of death at 30 days and 6 months, indepen-dent of the patient's age, gender, tumour stage and status; number of comorbidities; COVID-19 severity and receipt of anticancer and anti-COVID-19 therapy. Rates of permanent cessa-tion of anticancer therapy after COVID-19 were similar in the UK and EU cohorts. Interpretation: UK patients with cancer have been more severely impacted by the unfolding of the COVID-19 pandemic despite societal risk mitigation factors and rapid deferral of anti-cancer therapy. The increased frailty of UK patients with cancer highlights high-risk groups that should be prioritised for anti-SARS-CoV-2 vaccination. Continued evaluation of long-term outcomes is warranted. (C) 2021 Elsevier Ltd. All rights reserved.
Published: 2021

42. Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy.

Author: Carpentier J, Pavlyk I, Mukherjee U, Hall PE, and Szlosarek PW
Abstract: Arginine deprivation has gained increasing traction as a novel and safe antimetabolite strategy for the treatment of several hard-to-treat cancers characterised by a critical dependency on arginine. Small cell lung cancer (SCLC) displays marked arginine auxotrophy due to inactivation of the rate-limiting enzyme argininosuccinate synthetase 1 (ASS1), and as a consequence may be targeted with pegylated arginine deiminase or ADI-PEG20 (pegargiminase) and human recombinant pegylated arginases (rhArgPEG, BCT-100 and pegzilarginase). Although preclinical studies reveal that ASS1-deficient SCLC cell lines are highly sensitive to arginine-degrading enzymes, there is a clear disconnect with the clinic with minimal activity seen to date that may be due in part to patient selection. Recent studies have explored resistance mechanisms to arginine depletion focusing on tumor adaptation, such as ASS1 re-expression and autophagy, stromal cell inputs including macrophage infiltration, and tumor heterogeneity. Here, we explore how arginine deprivation may be combined strategically with novel agents to improve SCLC management by modulating resistance and increasing the efficacy of existing agents. Moreover, recent work has identified an intriguing role for targeting arginine in combination with PD-1/PD-L1 immune checkpoint inhibitors and clinical trials are in progress. Thus, future studies of arginine-depleting agents with chemoimmunotherapy, the current standard of care for SCLC, may lead to enhanced disease control and much needed improvements in long-term survival for patients., Competing Interests: Dr Szlosarek reports grant research support from Polaris Group. The remaining authors report no other conflicts of interest., (© 2022 Carpentier et al.)
Published: 2022
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43. COVID-19 Sequelae and the Host Proinflammatory Response: An Analysis From the OnCovid Registry.

Author: Cortellini A, Gennari A, Pommeret F, Patel G, Newsom-Davis T, Bertuzzi A, Viladot M, Aguilar-Company J, Mirallas O, Felip E, Lee AJX, Dalla Pria A, Sharkey R, Brunet J, Carmona-García M, Chester J, Mukherjee U, Scotti L, Dolly S, Sita-Lumsden A, Ferrante D, Van Hemelrijck M, Moss C, Russell B, Seguí E, Biello F, Krengli M, Marco-Hernández J, Gaidano G, Patriarca A, Bruna R, Roldán E, Fox L, Pous A, Griscelli F, Salazar R, Martinez-Vila C, Sureda A, Loizidou A, Maluquer C, Stoclin A, Iglesias M, Pedrazzoli P, Rizzo G, Santoro A, Rimassa L, Rossi S, Harbeck N, Sanchez de Torre A, Vincenzi B, Libertini M, Provenzano S, Generali D, Grisanti S, Berardi R, Tucci M, Mazzoni F, Lambertini M, Tagliamento M, Parisi A, Zoratto F, Queirolo P, Giusti R, Guida A, Zambelli A, Tondini C, Maconi A, Betti M, Colomba E, Diamantis N, Sinclair A, Bower M, Ruiz-Camps I, and Pinato DJ
Subjects: C-Reactive Protein analysis, COVID-19 Testing, Disease Progression, Humans, Lactate Dehydrogenases, Lymphocytes chemistry, Neutrophils chemistry, Prognosis, ROC Curve, Registries, Retrospective Studies, COVID-19 complications, COVID-19 epidemiology
Abstract: Background: Fifteen percent of patients with cancer experience symptomatic sequelae, which impair post-COVID-19 outcomes. In this study, we investigated whether a proinflammatory status is associated with the development of COVID-19 sequelae., Methods: OnCovid recruited 2795 consecutive patients who were diagnosed with Severe Acute Respiratory Syndrome Coronavirus 2 infection between February 27, 2020, and February 14, 2021. This analysis focused on COVID-19 survivors who underwent a clinical reassessment after the exclusion of patients with hematological malignancies. We evaluated the association of inflammatory markers collected at COVID-19 diagnosis with sequelae, considering the impact of previous systemic anticancer therapy. All statistical tests were 2-sided., Results: Of 1339 eligible patients, 203 experienced at least 1 sequela (15.2%). Median baseline C-reactive protein (CRP; 77.5 mg/L vs 22.2 mg/L, P < .001), lactate dehydrogenase (310 UI/L vs 274 UI/L, P = .03), and the neutrophil to lymphocyte ratio (NLR; 6.0 vs 4.3, P = .001) were statistically significantly higher among patients who experienced sequelae, whereas no association was reported for the platelet to lymphocyte ratio and the OnCovid Inflammatory Score, which includes albumin and lymphocytes. The widest area under the ROC curve (AUC) was reported for baseline CRP (AUC = 0.66, 95% confidence interval [CI]: 0.63 to 0.69), followed by the NLR (AUC = 0.58, 95% CI: 0.55 to 0.61) and lactate dehydrogenase (AUC = 0.57, 95% CI: 0.52 to 0.61). Using a fixed categorical multivariable analysis, high CRP (odds ratio [OR] = 2.56, 95% CI: 1.67 to 3.91) and NLR (OR = 1.45, 95% CI: 1.01 to 2.10) were confirmed to be statistically significantly associated with an increased risk of sequelae. Exposure to chemotherapy was associated with a decreased risk of sequelae (OR = 0.57, 95% CI: 0.36 to 0.91), whereas no associations with immune checkpoint inhibitors, endocrine therapy, and other types of systemic anticancer therapy were found., Conclusions: Although the association between inflammatory status, recent chemotherapy and sequelae warrants further investigation, our findings suggest that a deranged proinflammatory reaction at COVID-19 diagnosis may predict for sequelae development., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Published: 2022
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