6 results on '"Muhammad W. Feroze"'
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2. Author Correction: Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area
- Author
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Bryan M. Hooks, Andrew E. Papale, Ronald F. Paletzki, Muhammad W. Feroze, Brian S. Eastwood, Jonathan J. Couey, Johan Winnubst, Jayaram Chandrashekar, and Charles R. Gerfen
- Subjects
Science - Abstract
In the original version of this Article, support provided during initiation of the project was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from Karel Svoboda, members of the Svoboda lab, and members of Janelia’s Vivarium staff.
- Published
- 2018
- Full Text
- View/download PDF
3. High Mortality After Total Knee Arthroplasty Periprosthetic Joint Infection is Related to Preoperative Morbidity and the Disease Process but Not Treatment
- Author
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Nicholas P, Drain, Dominique M, Bertolini, Austin W, Anthony, Muhammad W, Feroze, Richard, Chao, Tito, Onyekweli, Sadie E, Longo, Beverly L, Hersh, Clair N, Smith, Scott D, Rothenberger, Neel B, Shah, and Kenneth L, Urish
- Subjects
Reoperation ,Arthritis, Infectious ,Prosthesis-Related Infections ,Frailty ,Humans ,Orthopedics and Sports Medicine ,Morbidity ,Arthroplasty, Replacement, Knee ,Retrospective Studies - Abstract
Periprosthetic joint infection (PJI) mortality rate is approximately 20%. The etiology for high mortality remains unknown. The objective of this study was to determine whether mortality was associated with preoperative morbidity (frailty), sequalae of treatment, or the PJI disease process itself.A multicenter observational study was completed comparing 184 patients treated with septic revision total knee arthroplasty (TKA) to a control group of 38 patients treated with aseptic revision TKA. Primary outcomes included time and the cause of death. Secondary outcomes included preoperative comorbidities and Charlson Comorbidity Index (CCMI) measured preoperatively and at various postoperative timepoints.The septic revision TKA cohort experienced earlier mortality compared to the aseptic cohort, with a higher mortality rate at 90 days, 1, 2, and 3 years after index revision surgery (P = .01). There was no significant difference for any single cause of death (P.05 for each). The mean preoperative CCMI was higher (P = .005) in the septic revision TKA cohort. Both septic and aseptic cohorts experienced a significant increase in CCMI from the preoperative to 3 years postoperative (P.0001 and P = .002) and time of death (P.0001 both) timepoints. The septic revision TKA cohort had a higher CCMI 3 years postoperatively (P = .001) and at time of death (P = .046), but not one year postoperatively (P = .119).Compared to mortality from aseptic revision surgery, septic revision TKA is associated with earlier mortality, but there is no single specific etiology. As quantified by changes in CCMI, PJI mortality was associated with both frailty and the PJI disease process, but not treatment.
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- 2022
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- View/download PDF
4. Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area
- Author
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Brian S. Eastwood, Jayaram Chandrashekar, Andrew E. Papale, Charles R. Gerfen, Bryan M. Hooks, Ronald F. Paletzki, Jonathan J. Couey, Muhammad W. Feroze, and Johan Winnubst
- Subjects
0301 basic medicine ,Cell type ,Science ,General Physics and Astronomy ,Sensory system ,Striatum ,Biology ,Brain mapping ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Basal ganglia ,medicine ,lcsh:Science ,10. No inequality ,Multidisciplinary ,Pyramidal tracts ,food and beverages ,General Chemistry ,Stereotypy (non-human) ,030104 developmental biology ,medicine.anatomical_structure ,lcsh:Q ,Neuroscience ,030217 neurology & neurosurgery ,Motor cortex - Abstract
The striatum shows general topographic organization and regional differences in behavioral functions. How corticostriatal topography differs across cortical areas and cell types to support these distinct functions is unclear. This study contrasted corticostriatal projections from two layer 5 cell types, intratelencephalic (IT-type) and pyramidal tract (PT-type) neurons, using viral vectors expressing fluorescent reporters in Cre-driver mice. Corticostriatal projections from sensory and motor cortex are somatotopic, with a decreasing topographic specificity as injection sites move from sensory to motor and frontal areas. Topographic organization differs between IT-type and PT-type neurons, including injections in the same site, with IT-type neurons having higher topographic stereotypy than PT-type neurons. Furthermore, IT-type projections from interconnected cortical areas have stronger correlations in corticostriatal targeting than PT-type projections do. As predicted by a longstanding model, corticostriatal projections of interconnected cortical areas form parallel circuits in the basal ganglia.
- Published
- 2018
5. Author Correction: Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area
- Author
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Johan Winnubst, Andrew E. Papale, Muhammad W. Feroze, Bryan M. Hooks, Jonathan J. Couey, Ronald F. Paletzki, Jayaram Chandrashekar, Charles R. Gerfen, and Brian S. Eastwood
- Subjects
0301 basic medicine ,Science ,Models, Neurological ,Pyramidal Tracts ,General Physics and Astronomy ,Sensory system ,Basal Ganglia ,Article ,General Biochemistry, Genetics and Molecular Biology ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Neural Pathways ,Animals ,Author Correction ,lcsh:Science ,computer.programming_language ,Cerebral Cortex ,Neurons ,Brain Mapping ,Multidisciplinary ,Vivarium ,Motor Cortex ,Somatosensory Cortex ,General Chemistry ,Corpus Striatum ,030104 developmental biology ,Karel ,lcsh:Q ,Psychology ,computer ,Cartography ,030217 neurology & neurosurgery - Abstract
The striatum shows general topographic organization and regional differences in behavioral functions. How corticostriatal topography differs across cortical areas and cell types to support these distinct functions is unclear. This study contrasted corticostriatal projections from two layer 5 cell types, intratelencephalic (IT-type) and pyramidal tract (PT-type) neurons, using viral vectors expressing fluorescent reporters in Cre-driver mice. Corticostriatal projections from sensory and motor cortex are somatotopic, with a decreasing topographic specificity as injection sites move from sensory to motor and frontal areas. Topographic organization differs between IT-type and PT-type neurons, including injections in the same site, with IT-type neurons having higher topographic stereotypy than PT-type neurons. Furthermore, IT-type projections from interconnected cortical areas have stronger correlations in corticostriatal targeting than PT-type projections do. As predicted by a longstanding model, corticostriatal projections of interconnected cortical areas form parallel circuits in the basal ganglia., How corticostriatal connections of different pyramidal cell types are organized, particularly in convergent circuits, has not been evaluated in detail. Here, cell type-specific Cre-driver mice reveal that pyramidal tract-type corticostriatal projections, though broadly similar to intratelencephalic-type projections from the same cortical region, are generally more restricted and variable in their topographic termination patterns.
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- 2018
- Full Text
- View/download PDF
6. Cell type-specific variation of somatotopic precision across corticostriatal projections
- Author
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Jayaram Chandrashekar, Jonathan J. Couey, Muhammad W. Feroze, Brian S. Eastwood, Johan Winnubst, Ronald F. Paletzki, Bryan M. Hooks, Andrew E. Papale, and Charles R. Gerfen
- Subjects
0303 health sciences ,Cell type ,Pyramidal tracts ,Sensory system ,Striatum ,Biology ,03 medical and health sciences ,Basal (phylogenetics) ,Stereotypy (non-human) ,0302 clinical medicine ,medicine.anatomical_structure ,Basal ganglia ,medicine ,Neuroscience ,030217 neurology & neurosurgery ,030304 developmental biology ,Motor cortex - Abstract
The striatum shows general topographic organization and regional differences in behavioral functions. How corticostriatal topography differs across cortical areas and cell types to support these distinct functions is unclear. This study contrasted corticostriatal projections from two layer 5 cell types, intratelencephalic (IT-type) and pyramidal tract (PT-type) neurons, using viral vectors expressing fluorescent reporters in Cre-driver mice. Long-range corticostriatal projections from sensory and motor cortex are somatotopic, with a decreasing somatotopic specificity as injections move from sensory to motor and frontal areas. Somatotopic organization differs between IT-type and PT-type neurons, including injections in the same site, with IT-type neurons having higher somatotopic stereotypy than PT-type neurons. Furthermore, IT-type projections from interconnected cortical areas have stronger correlations in corticostriatal targeting than PT-type projections do. Thus, as predicted by a long-standing basal ganglia model, corticostriatal projections of interconnected cortical areas form parallel circuits in basal ganglia-thalamus-cortex loops.
- Published
- 2018
- Full Text
- View/download PDF
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